#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P04591 uniprotkb:Q9HD40 intact:EBI-6163428 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9Y2W1 intact:EBI-6163428 intact:EBI-352039|uniprotkb:Q5VTK6|uniprotkb:D3DPS5|ensembl:ENSP00000346634|ensembl:ENSP00000433825 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:tr150_human(display_long)|uniprotkb:BCLAF1 and THRAP3 family member 2(gene name synonym)|uniprotkb:BCLAF2(gene name synonym)|uniprotkb:THRAP3(gene name)|psi-mi:THRAP3(display_short)|uniprotkb:TRAP150(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 150 kDa component(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_005110.2|ensembl:ENSG00000054118(gene)|ensembl:ENST00000354618(transcript)|ensembl:ENST00000469141(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016592"(mediator complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR026667|interpro:IPR029199|mint:Q9Y2W1|reactome:R-HSA-1989781|reactome:R-HSA-381340|refseq:NP_001308400.1|refseq:NP_001308402.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:pPyZVG1IXg/+QDpHngwzUX09cBM9606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q99873 intact:EBI-6163428 intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9Y6Y0 intact:EBI-6163428 intact:EBI-715774|uniprotkb:Q1G4T6|uniprotkb:Q1G4T7|uniprotkb:Q5TF75|uniprotkb:Q6NW38|uniprotkb:Q7LCG2|uniprotkb:Q9NZX0|uniprotkb:Q9Y480|uniprotkb:A8K8R6|ensembl:ENSP00000356468 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ns1bp_human(display_long)|uniprotkb:Aryl hydrocarbon receptor-associated protein 3(gene name synonym)|uniprotkb:IVNS1ABP(gene name)|psi-mi:IVNS1ABP(display_short)|uniprotkb:ARA3(gene name synonym)|uniprotkb:FLARA3(gene name synonym)|uniprotkb:KIAA0850(gene name synonym)|uniprotkb:NS1(gene name synonym)|uniprotkb:NS1BP(gene name synonym)|uniprotkb:HSPC068(orf name)|uniprotkb:KLHL39(gene name synonym)|uniprotkb:Kelch-like protein 39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_006460.2|ensembl:ENSG00000116679(gene)|ensembl:ENST00000367498(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0008380"(RNA splicing)|go:"GO:0009615"(response to virus)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR017096(Kelch-like protein, gigaxonin)|rcsb pdb:5YY8|rcsb pdb:6N34|rcsb pdb:6N3H|interpro:IPR015915(Kelch-type beta propeller) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:27jzoex7cmDEgCPCpPMGbZ0pj489606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:P19525 intact:EBI-6163428 intact:EBI-640775|uniprotkb:D6W584|uniprotkb:Q52M43|uniprotkb:Q9UIR4|uniprotkb:A8K3P0|ensembl:ENSP00000233057|ensembl:ENSP00000378559|ensembl:ENSP00000497534|ensembl:ENSP00000505138|ensembl:ENSP00000505772|ensembl:ENSP00000506024|uniprotkb:E9PC80|uniprotkb:Q7Z6F6 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:e2ak2_human(display_long)|uniprotkb:Interferon-inducible RNA-dependent protein kinase(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 2(gene name synonym)|uniprotkb:Protein kinase RNA-activated(gene name synonym)|uniprotkb:p68 kinase(gene name synonym)|uniprotkb:P1/eIF-2A protein kinase(gene name synonym)|uniprotkb:EIF2AK2(gene name)|psi-mi:EIF2AK2(display_short)|uniprotkb:PKR(gene name synonym)|uniprotkb:PRKR(gene name synonym)|uniprotkb:Tyrosine-protein kinase EIF2AK2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_001129124.1|refseq:NP_001129123.1|refseq:NP_002750.1|ensembl:ENSG00000055332(gene)|ensembl:ENST00000233057(transcript)|ensembl:ENST00000395127(transcript)|ensembl:ENST00000647926(transcript)|ensembl:ENST00000679507(transcript)|ensembl:ENST00000681463(transcript)|ensembl:ENST00000681507(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044452|interpro:IPR044453|mint:P19525|rcsb pdb:1QU6|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3UIU|rcsb pdb:6D3K|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6D3L|reactome:R-HSA-1169408|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-169131|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900225"(regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902033"(regulation of hematopoietic stem cell proliferation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-2657N|refseq:XP_011531289.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:2Pc405Bc/xKDHC1O24GhGC5JJzU9606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q96I25 intact:EBI-6163428 intact:EBI-740272|uniprotkb:Q96GY6|ensembl:ENSP00000369218|ensembl:ENSP00000388638 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spf45_human(display_long)|uniprotkb:45 kDa-splicing factor(gene name synonym)|uniprotkb:RNA-binding motif protein 17(gene name synonym)|uniprotkb:RBM17(gene name)|psi-mi:RBM17(display_short)|uniprotkb:SPF45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_001139019.1|refseq:NP_116294.1|ensembl:ENSG00000134453(gene)|ensembl:ENST00000379888(transcript)|ensembl:ENST00000446108(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0043484"(regulation of RNA splicing)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034653|interpro:IPR035979|interpro:IPR040052|mint:Q96I25|rcsb pdb:2PE8|rcsb pdb:2PEH|rcsb pdb:5LSO|rcsb pdb:6HIP|reactome:R-HSA-72163|dip:DIP-29409N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:Vhyfu0XQEzUpy7smEsSHj1s5O+49606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9Y6V7 intact:EBI-6163428 intact:EBI-719274|uniprotkb:Q53FJ1|uniprotkb:E7ENA0|uniprotkb:Q9BVQ8|ensembl:ENSP00000247003 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ddx49_human(display_long)|uniprotkb:DEAD box protein 49(gene name synonym)|uniprotkb:DDX49(gene name)|psi-mi:DDX49(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_061943.2|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|ensembl:ENST00000247003(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006364"(rRNA processing)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9Y6V7|go:"GO:0030307"(positive regulation of cell growth)|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0044357"(regulation of rRNA stability)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|ensembl:ENSG00000105671(gene) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:Yfej1zXpPTue3eewQcR5OpNILeM9606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9NTK5 intact:EBI-6163428 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174225|imex:IM-17346-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 intact-crc:40AF82A4B79E399A|rigid:5FTsK3YAnksvBLynvrByiEXUSG0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q15165 intact:EBI-6179761 intact:EBI-3909798|ensembl:ENSP00000222572|ensembl:ENSP00000488838|uniprotkb:O15114|uniprotkb:B4DJD5|uniprotkb:Q5FBX7|uniprotkb:O15115|uniprotkb:B2RCP9|uniprotkb:Q86YL0|uniprotkb:O75856|uniprotkb:A4D1H7|intact:EBI-10966394 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pon2_human(display_long)|uniprotkb:PON2(gene name)|psi-mi:PON2(display_short)|uniprotkb:Aromatic esterase 2(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000105854(gene)|ensembl:ENST00000222572(transcript)|ensembl:ENST00000633531(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019439"(aromatic compound catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|interpro:IPR002640(Arylesterase)|interpro:IPR008364(Paraoxonase2)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|mint:Q15165|reactome:R-HSA-2142688|refseq:NP_000296.2|dip:DIP-61136N|refseq:NP_001018171.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:9zE87aut0R8eYxaXM+HgYsJxLYI9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q14697 intact:EBI-6179761 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P51665 intact:EBI-6179761 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BRK5 intact:EBI-6179761 intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O15460 intact:EBI-6179761 intact:EBI-348033|ensembl:ENSP00000166534|ensembl:ENSP00000368398|ensembl:ENSP00000384999|uniprotkb:Q8WWN0|uniprotkb:D3DQ85|uniprotkb:D3DQ86 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:p4ha2_human(display_long)|uniprotkb:UNQ290/PRO330(orf name)|uniprotkb:P4HA2(gene name)|psi-mi:P4HA2(display_short)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENST00000166534(transcript)|ensembl:ENST00000379104(transcript)|ensembl:ENST00000401867(transcript)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0009055"(electron transfer activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013547(Prolyl 4-hydroxylase alpha-subunit, N-terminal)|interpro:IPR019734|mint:O15460|rcsb pdb:6EVL|rcsb pdb:6EVM|rcsb pdb:6EVN|rcsb pdb:6EVO|rcsb pdb:6EVP|reactome:R-HSA-1650814|ensembl:ENSG00000072682(gene)|refseq:NP_001136071.1|refseq:NP_004190.1|refseq:NP_001017973.1|refseq:NP_001017974.1|refseq:NP_001136070.1|refseq:XP_016865500.1|refseq:XP_005272173.1|refseq:XP_005272174.1|refseq:XP_005272175.1|refseq:XP_005272176.1|refseq:XP_005272177.1|refseq:XP_006714791.1|refseq:XP_006714792.1|refseq:XP_006714793.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:VppOE5KSA6wKWCFN4mCUJsFHDIA9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q99470 intact:EBI-6179761 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9UBS4 intact:EBI-6179761 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O00231 intact:EBI-6179761 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9HCN8 intact:EBI-6179761 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P14314 intact:EBI-6179761 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9Y4L1 intact:EBI-6179761 intact:EBI-1054186|uniprotkb:Q2I204|uniprotkb:Q53H25|uniprotkb:B7Z909|uniprotkb:A8C1Z0|ensembl:ENSP00000480150|ensembl:ENSP00000486825 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hyou1_human(display_long)|uniprotkb:150 kDa oxygen-regulated protein(gene name synonym)|uniprotkb:GRP170(gene name synonym)|uniprotkb:HYOU1(gene name)|psi-mi:HYOU1(display_short)|uniprotkb:ORP150(gene name synonym)|uniprotkb:170 kDa glucose-regulated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174266|imex:IM-17346-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001124463.1|refseq:NP_006380.1|refseq:XP_016872585.1|refseq:XP_016872586.1|ensembl:ENSG00000149428(gene)|ensembl:ENSG00000280682(gene)|ensembl:ENST00000617285(transcript)|ensembl:ENST00000630669(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:Q9Y4L1|reactome:R-HSA-3000484|reactome:R-HSA-381038|go:"GO:0005790"(smooth endoplasmic reticulum) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:xqSFRaiiHJLNVqgh87tHx9lfnS49606 intact-crc:8A98A3328A658A50|rigid:1ccUuqiSwMkfsEaa8jNiOaeeME0 false mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14574 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6163585|intact:EBI-28985956|uniprotkb:A6NN35|uniprotkb:Q14200|uniprotkb:Q9HAZ9|ensembl:ENSP00000353608 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:dsc3_human(display_long)|uniprotkb:Cadherin family member 3(gene name synonym)|uniprotkb:DSC4(gene name synonym)|uniprotkb:Desmocollin-4(gene name synonym)|uniprotkb:HT-CP(gene name synonym)|uniprotkb:DSC3(gene name)|psi-mi:DSC3(display_short)|uniprotkb:CDHF3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001932.2|refseq:NP_077741.2|ensembl:ENSP00000392068|ensembl:ENST00000434452|ensembl:ENSP00000353608|ensembl:ENSG00000134762(gene)|ensembl:ENST00000360428(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q14574|reactome:R-HSA-6805567|reactome:R-HSA-6809371|interpro:IPR002126(Cadherin) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:2En63we0WgDfQQY2f4qQHK/clSI9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:B0FAM1 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6163546 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:b0fam1_9hiv1(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR000328(Envelope Polyprotein GP41) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.98 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11676 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P14314 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P49257 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBV2 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P10321 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P13073 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P10321 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P07237 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q15165 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-3909798|ensembl:ENSP00000222572|ensembl:ENSP00000488838|uniprotkb:O15114|uniprotkb:B4DJD5|uniprotkb:Q5FBX7|uniprotkb:O15115|uniprotkb:B2RCP9|uniprotkb:Q86YL0|uniprotkb:O75856|uniprotkb:A4D1H7|intact:EBI-10966394 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pon2_human(display_long)|uniprotkb:PON2(gene name)|psi-mi:PON2(display_short)|uniprotkb:Aromatic esterase 2(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000105854(gene)|ensembl:ENST00000222572(transcript)|ensembl:ENST00000633531(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019439"(aromatic compound catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|interpro:IPR002640(Arylesterase)|interpro:IPR008364(Paraoxonase2)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|mint:Q15165|reactome:R-HSA-2142688|refseq:NP_000296.2|dip:DIP-61136N|refseq:NP_001018171.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9zE87aut0R8eYxaXM+HgYsJxLYI9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q99470 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P28072 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P10321 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P21796 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q07065 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P45880 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14697 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P10321 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9Y287 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P04439 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1042870|uniprotkb:O02963|uniprotkb:O78073|uniprotkb:P79563|uniprotkb:Q30208|uniprotkb:Q31623|uniprotkb:Q95377|uniprotkb:Q9BD15|uniprotkb:Q9BD19|uniprotkb:Q9MW42|uniprotkb:Q9TQK5|ensembl:ENSP00000366005|ensembl:ENSP00000379873|intact:EBI-1050524|intact:EBI-1049899|intact:EBI-2839447|intact:EBI-1044129|intact:EBI-8770309|intact:EBI-21249599|uniprotkb:B1PKZ3|uniprotkb:O02939|uniprotkb:O02954|uniprotkb:O02955|uniprotkb:O19509|uniprotkb:O19546|uniprotkb:O19598|uniprotkb:O19605|uniprotkb:O19606|uniprotkb:O19619|uniprotkb:O19647|uniprotkb:O19673|uniprotkb:O19687|uniprotkb:O19695|uniprotkb:O19756|uniprotkb:O19794|uniprotkb:O19795|uniprotkb:O43906|uniprotkb:O43907|uniprotkb:O46874|uniprotkb:O62921|uniprotkb:O62924|uniprotkb:O77937|uniprotkb:O77938|uniprotkb:O77964|uniprotkb:O78171|uniprotkb:O98009|uniprotkb:P30455|uniprotkb:P30456|uniprotkb:P30457|uniprotkb:P30458|uniprotkb:O98010|uniprotkb:O98011|uniprotkb:O98137|uniprotkb:P01891|uniprotkb:P01892|uniprotkb:P05534|uniprotkb:P06338|uniprotkb:P10313|uniprotkb:P10314|uniprotkb:P10315|uniprotkb:P10316|uniprotkb:P13746|uniprotkb:P16188|uniprotkb:P16189|uniprotkb:P16190|uniprotkb:P18462|uniprotkb:P30443|uniprotkb:P30444|uniprotkb:P30445|uniprotkb:P30446|uniprotkb:P30447|uniprotkb:P30448|uniprotkb:P30449|uniprotkb:P30450|uniprotkb:P30451|uniprotkb:P30514|uniprotkb:P79505|uniprotkb:P79562|uniprotkb:Q09160|uniprotkb:Q29680|uniprotkb:P30512|uniprotkb:Q29747|uniprotkb:Q29835|uniprotkb:Q29837|uniprotkb:Q29838|uniprotkb:Q29899|uniprotkb:Q29908|uniprotkb:Q29909|uniprotkb:Q29910|uniprotkb:Q5S3G1|uniprotkb:Q65A82|uniprotkb:Q8MHM1|uniprotkb:Q8MHN9|uniprotkb:Q95352|uniprotkb:Q95355|uniprotkb:P30452|uniprotkb:P30459|uniprotkb:Q95380|uniprotkb:Q95IZ5|uniprotkb:Q9BCN0|uniprotkb:Q9GJE6|uniprotkb:Q9GJE7|uniprotkb:Q9GJE8|uniprotkb:Q9MY89|uniprotkb:Q9MYA3|uniprotkb:Q9MYA5|uniprotkb:Q9MYC4|uniprotkb:Q9MYE6|uniprotkb:Q9MYE9|uniprotkb:Q9MYG4|uniprotkb:Q9MYG5|uniprotkb:Q9MYI5|uniprotkb:Q9TP25|uniprotkb:Q9TPQ3|uniprotkb:Q9TPR8|uniprotkb:Q9TPX8|uniprotkb:Q9TPX9|uniprotkb:Q9TPY0|uniprotkb:Q95362|uniprotkb:Q9TQ24|uniprotkb:Q9TQE8|uniprotkb:Q9TQE9|uniprotkb:Q9TQF1|uniprotkb:Q9TQF5|uniprotkb:Q9TQF8|uniprotkb:Q9TQF9|uniprotkb:Q9TQG0|uniprotkb:Q9TQG5|uniprotkb:Q9TQG7|uniprotkb:Q9TQH5|uniprotkb:Q9TQI3|uniprotkb:Q9TQM6|uniprotkb:Q9TQN5|uniprotkb:Q9TQP5|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q9UIN1|uniprotkb:Q9UIN2|uniprotkb:Q9UIP7|uniprotkb:Q9UQU3|uniprotkb:Q9UQU6|uniprotkb:Q9UQU7|uniprotkb:P30453|uniprotkb:P30454|intact:EBI-1050350|intact:EBI-21505155 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlaa_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENST00000376809(transcript)|ensembl:ENST00000396634(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002419"(T cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|ensembl:ENSG00000206503(gene)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0062061"(TAP complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2000568"(positive regulation of memory T cell activation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P04439|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1Q94|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1QVO|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TMC|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:1W72|rcsb pdb:1X7Q|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BCK|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:1P7Q|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1HSB|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:5HGH|rcsb pdb:5HHM|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:5HYJ|rcsb pdb:5IRO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5JZI|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:5N1Y|rcsb pdb:5N6B|rcsb pdb:5NHT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MGT|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3NFN|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:3QFD|rcsb pdb:3QFJ|rcsb pdb:3QZW|rcsb pdb:3REW|rcsb pdb:3RL1|rcsb pdb:3RL2|rcsb pdb:3TO2|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3WL9|rcsb pdb:3WLB|rcsb pdb:4E5X|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4EUP|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|rcsb pdb:4FTV|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:4L3E|rcsb pdb:4MJ5|rcsb pdb:4MJ6|rcsb pdb:4MNQ|rcsb pdb:4N8V|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4NO3|rcsb pdb:4GKN|rcsb pdb:4NO5|rcsb pdb:4NQV|rcsb pdb:4NQX|rcsb pdb:4OV5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4GKS|rcsb pdb:4HWZ|rcsb pdb:4HX1|rcsb pdb:4U6Y|rcsb pdb:4UQ2|rcsb pdb:4UQ3|rcsb pdb:4I48|rcsb pdb:4WJ5|rcsb pdb:4I4W|rcsb pdb:4WU5|rcsb pdb:4JFD|rcsb pdb:4WU7|rcsb pdb:4WUU|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|rcsb pdb:4K7F|rcsb pdb:5BRZ|rcsb pdb:5BS0|rcsb pdb:5C07|rcsb pdb:5C08|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:5NQK|rcsb pdb:5SWQ|rcsb pdb:5TEZ|rcsb pdb:5W1W|rcsb pdb:5WJL|rcsb pdb:5WJN|rcsb pdb:5WKF|rcsb pdb:5WKH|rcsb pdb:5WSH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|rcsb pdb:5XOV|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|rcsb pdb:6AT9|rcsb pdb:6D78|rcsb pdb:6D7G|rcsb pdb:6DKP|rcsb pdb:6EI2|rcsb pdb:6ENY|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:5NME|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0C|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5D2L|rcsb pdb:5D2N|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E00|rcsb pdb:5E6I|rcsb pdb:5E9D|rcsb pdb:5ENW|rcsb pdb:5EOT|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5GRD|rcsb pdb:5GRG|rcsb pdb:5GSD|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:6EWA|rcsb pdb:6SS7|rcsb pdb:6SS8|rcsb pdb:6SS9|rcsb pdb:6SSA|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|reactome:R-HSA-198933|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8866654|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6RSY|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6G3J|rcsb pdb:6G3K|rcsb pdb:6ID4|rcsb pdb:6J1W|rcsb pdb:6J29|rcsb pdb:6J2A|rcsb pdb:6JOZ|rcsb pdb:6JP3|rcsb pdb:6MPP|rcsb pdb:6NCA|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6OPD|rcsb pdb:6PBH|rcsb pdb:6PTB|rcsb pdb:6PTE|rcsb pdb:6Q3K|rcsb pdb:6Q3S|rcsb pdb:6R2L|rcsb pdb:6RP9|rcsb pdb:6RPA|rcsb pdb:6RPB|rcsb pdb:2GUO|rcsb pdb:2HLA|rcsb pdb:2HN7|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:2XPG|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3BO8|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3I6L|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|refseq:NP_002107.3|refseq:NP_001229687.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:RNvdwEiEB2h1Qfvd4BEIKiGzw1s9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9HCN8 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01892 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2839473|uniprotkb:Q9TPY0|uniprotkb:Q29680|uniprotkb:Q29899|uniprotkb:P06338|uniprotkb:P30445|uniprotkb:Q95352|uniprotkb:Q9TQI3|uniprotkb:Q95380|uniprotkb:P30444|uniprotkb:Q9TPX8|uniprotkb:O19619|uniprotkb:P30446|uniprotkb:Q9TQH5|uniprotkb:P10313|uniprotkb:Q9TPX9|uniprotkb:P30514|uniprotkb:Q29837 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:1a02_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A*02(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:4MNQ|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5C0C|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5HYJ|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4OV5|rcsb pdb:4UQ3|ensembl:ENSG00000227715|ensembl:ENSP00000448077|ensembl:ENST00000547522|rcsb pdb:5SWQ|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5HHM|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E6I|rcsb pdb:5IRO|rcsb pdb:6D7G|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016567"(protein ubiquitination)|rcsb pdb:5D2L|rcsb pdb:5D2N|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|rcsb pdb:4WJ5|go:"GO:0003723"(RNA binding)|go:"GO:0055038"(recycling endosome membrane)|rcsb pdb:5E00|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:6EWA|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:4NO3|rcsb pdb:4NO5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4U6Y|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|go:"GO:0031901"(early endosome membrane)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0000139"(Golgi membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0050690"(regulation of defense response to virus by virus)|go:"GO:0060337"(type I interferon signaling pathway)|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:1P7Q|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:2GUO|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|rcsb pdb:3MGT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0009986"(cell surface)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0046977"(TAP binding)|go:"GO:2000568"(positive regulation of memory T cell activation)|rcsb pdb:3QFD|rcsb pdb:4K7F|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0002480"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent)|go:"GO:0030670"(phagocytic vesicle membrane)|rcsb pdb:3QFJ|rcsb pdb:3REW|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:5NMG|rcsb pdb:5NHT|rcsb pdb:5NQK|rcsb pdb:4WUU|rcsb pdb:4E5X|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:4I4W|rcsb pdb:5EOT|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:3TO2|rcsb pdb:4GKN|rcsb pdb:4GKS|rcsb pdb:4EUP|reactome:R-HSA-198933|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|go:"GO:0042608"(T cell receptor binding)|rcsb pdb:4L3E|ensembl:ENSG00000235657|ensembl:ENSP00000403575|ensembl:ENSP00000447962|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|rcsb pdb:4FTV|rcsb pdb:5E9D|rcsb pdb:5C07|rcsb pdb:5C08|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0050776"(regulation of immune response)|ensembl:ENST00000457879|ensembl:ENST00000547271|go:"GO:0051290"(protein heterotetramerization)|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5N1Y|go:"GO:0002250"(adaptive immune response)|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6D78|rcsb pdb:6DKP|rcsb pdb:5ENW|reactome:R-HSA-8866654|rcsb pdb:5JZI|interpro:IPR036179|interpro:IPR037055|rcsb pdb:5TEZ|rcsb pdb:5WSH|mint:P01892|rcsb pdb:5N6B|rcsb pdb:5W1W|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0062061"(TAP complex binding)|rcsb pdb:6G3J psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - no-uniprot-update:Deprecated HLA-A AC, merged into a different UniProt canonical but we have mutation features in variable positions.|comment:"Allele =A*02:01:01:01"|comment:"Allele =A*02:01:01:01 according to IPD-IMGT/HLA database"|author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:oTL0BWZeACoxMc++WgT0XDz+sNg9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O94901 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2796904|uniprotkb:B7WP53|uniprotkb:Q9UH98|uniprotkb:Q9HA14|uniprotkb:B7WNY4|uniprotkb:B3KMV7|uniprotkb:Q96CZ7|uniprotkb:B4DZF7|uniprotkb:E9PDU4|uniprotkb:A5PL20|uniprotkb:E9PF23|uniprotkb:F8WD13|ensembl:ENSP00000384015 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sun1_human(display_long)|uniprotkb:KIAA0810(gene name synonym)|uniprotkb:UNC84A(gene name synonym)|uniprotkb:Protein unc-84 homolog A(gene name synonym)|uniprotkb:Sad1/unc-84 protein-like 1(gene name synonym)|uniprotkb:SUN1(gene name)|psi-mi:SUN1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001165416.1|refseq:NP_001124437.1|refseq:NP_001165415.1|refseq:NP_001165417.1|refseq:NP_079430.3|ensembl:ENSG00000164828(gene)|ensembl:ENST00000401592(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|go:"GO:0070197"(meiotic attachment of telomere to nuclear envelope)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR018539|interpro:IPR032680|interpro:IPR040994|mint:O94901|rcsb pdb:6R15|rcsb pdb:6R16|rcsb pdb:6R2I|rcsb pdb:7E34|reactome:R-HSA-1221632 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:RJbLHCT6Gemrj6FLPEGesQcBGjY9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P27797 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P05067 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O75955 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P25786 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9BYC5 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2869363|uniprotkb:Q9P2U6|uniprotkb:Q9P2U5|uniprotkb:O00235|uniprotkb:Q9BYC6|uniprotkb:B4DFS7|uniprotkb:G3V5N0|uniprotkb:Q8IUA5|ensembl:ENSP00000353910|ensembl:ENSP00000501213|ensembl:ENSP00000378087 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:fut8_human(display_long)|uniprotkb:FUT8(gene name)|psi-mi:FUT8(display_short)|uniprotkb:Fucosyltransferase 8(gene name synonym)|uniprotkb:"GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase"(gene name synonym)|uniprotkb:GDP-fucose--glycoprotein fucosyltransferase(gene name synonym)|uniprotkb:Glycoprotein 6-alpha-L-fucosyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_004471.4|refseq:NP_835368.1|refseq:NP_835369.1|ensembl:ENSG00000033170(gene)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6VLE|go:"GO:1900407"(regulation of cellular response to oxidative stress)|interpro:IPR001452(Src homology-3)|rcsb pdb:6X5H|interpro:IPR015827("Alpha-(1,6)-fucosyltransferase, eukaryotic type")|interpro:IPR027350|interpro:IPR035653|interpro:IPR036028|mint:Q9BYC5|rcsb pdb:2DE0|rcsb pdb:6VLD|rcsb pdb:6X5R|rcsb pdb:6X5S|rcsb pdb:6X5T|rcsb pdb:6X5U|reactome:R-HSA-9694548|reactome:R-HSA-975578|ensembl:ENST00000360689(transcript)|ensembl:ENST00000394586(transcript)|ensembl:ENST00000673929(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006491"(N-glycan processing)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008424"(glycoprotein 6-alpha-L-fucosyltransferase activity)|go:"GO:0009312"(oligosaccharide biosynthetic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0019082"(viral protein processing)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033578"(protein glycosylation in Golgi)|go:"GO:0036071"(N-glycan fucosylation)|go:"GO:0042355"(L-fucose catabolic process)|go:"GO:0043112"(receptor metabolic process)|go:"GO:0046368"(GDP-L-fucose metabolic process)|go:"GO:0046921"("alpha-(1->6)-fucosyltransferase activity") psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:4ExQD5i1NzMB4ZN+jMDAgEDfXmg9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96DZ1 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P10321 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P10321 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1051396|uniprotkb:O78067|uniprotkb:O78072|uniprotkb:O78090|uniprotkb:O78149|uniprotkb:Q29921|uniprotkb:Q9UM42|intact:EBI-13916949|uniprotkb:O02863|intact:EBI-6163576|intact:EBI-4400689|intact:EBI-6163558|uniprotkb:O02864|uniprotkb:O02865|uniprotkb:O02866|uniprotkb:O02958|uniprotkb:O19505|uniprotkb:O19652|uniprotkb:O19676|uniprotkb:O62879|uniprotkb:O62882|uniprotkb:O62883|uniprotkb:O62888|uniprotkb:O78060|uniprotkb:O78061|uniprotkb:O78062|uniprotkb:O78063|uniprotkb:O78068|uniprotkb:O78069|uniprotkb:O78083|uniprotkb:O78091|uniprotkb:O78165|uniprotkb:O78166|uniprotkb:O78178|uniprotkb:O78202|uniprotkb:O78203|uniprotkb:O78211|uniprotkb:O78214|uniprotkb:P04222|uniprotkb:P30499|uniprotkb:P30500|uniprotkb:P30501|uniprotkb:P30502|uniprotkb:P30503|uniprotkb:P30504|uniprotkb:P30505|uniprotkb:P30506|uniprotkb:P30507|uniprotkb:P30508|uniprotkb:P30509|uniprotkb:P30510|uniprotkb:P79498|uniprotkb:Q07000|uniprotkb:Q29631|uniprotkb:Q29641|uniprotkb:Q29643|uniprotkb:Q29652|uniprotkb:Q29743|uniprotkb:Q29768|uniprotkb:Q29862|uniprotkb:Q29864|uniprotkb:Q29865|uniprotkb:Q29867|uniprotkb:Q29959|uniprotkb:Q29960|uniprotkb:Q29963|uniprotkb:Q29986|uniprotkb:Q29989|uniprotkb:Q9MY74|uniprotkb:Q9MYI3|uniprotkb:Q9TNN7|uniprotkb:Q9TNZ8|uniprotkb:Q9TPS4|uniprotkb:Q9TPV8|uniprotkb:Q9TPX2|uniprotkb:Q9TQB4|uniprotkb:Q9TQJ5|uniprotkb:Q9TQP9|uniprotkb:Q9UM32|uniprotkb:Q9UM33|uniprotkb:Q9UQS9|uniprotkb:Q29990|uniprotkb:Q29991|uniprotkb:Q29992|uniprotkb:Q29993|uniprotkb:Q30192|uniprotkb:Q31605|uniprotkb:Q31627|uniprotkb:Q9GJ33|uniprotkb:Q9MY30|uniprotkb:Q860R1|uniprotkb:Q860R2|uniprotkb:Q95463|uniprotkb:Q95603|uniprotkb:Q95604|uniprotkb:Q99528|uniprotkb:Q9BD28|uniprotkb:Q9GIK4|uniprotkb:Q9GIK8|intact:EBI-9978491|intact:EBI-3905378|intact:EBI-6163573|intact:EBI-1058803|intact:EBI-13917304|uniprotkb:Q9MY31|uniprotkb:Q9MY35|uniprotkb:Q9MY49|ensembl:ENSP00000365402 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlac_human(display_long)|uniprotkb:HLA-Cw(gene name synonym)|uniprotkb:Human leukocyte antigen C(gene name synonym)|uniprotkb:HLAC(gene name synonym)|uniprotkb:HLA-C(gene name)|psi-mi:HLA-C(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002108.4|ensembl:ENSG00000204525(gene)|ensembl:ENST00000376228(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P10321|rcsb pdb:1EFX|rcsb pdb:1IM9|rcsb pdb:1QQD|rcsb pdb:3BZF|rcsb pdb:4NT6|rcsb pdb:5VGD|rcsb pdb:5VGE|rcsb pdb:5W67|rcsb pdb:5W69|rcsb pdb:5W6A|rcsb pdb:6JTO|rcsb pdb:6PA1|rcsb pdb:6PAG|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VYYWt9SpNZEuu0jZkdCHEe65lAE9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01889 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046513|ensembl:ENSP00000399168|uniprotkb:O62901|uniprotkb:O95730|uniprotkb:O98140|uniprotkb:P79542|uniprotkb:Q95369|uniprotkb:Q95J00|uniprotkb:Q9GJ20|uniprotkb:Q9MY78|uniprotkb:Q9MYF4|uniprotkb:Q9TQH6|uniprotkb:Q9TQM2|uniprotkb:Q9UQT0|intact:EBI-1049793|intact:EBI-6163549|intact:EBI-6163552|intact:EBI-6163582|intact:EBI-6163570|intact:EBI-6163579|intact:EBI-6163555|intact:EBI-9978548|intact:EBI-1047909|intact:EBI-8770324|uniprotkb:A0A2I6Q7B5|uniprotkb:B0V0B8|uniprotkb:G3GN01|uniprotkb:O02862|uniprotkb:O02956|uniprotkb:O02957|uniprotkb:O02960|uniprotkb:O19555|uniprotkb:O19556|uniprotkb:O19595|uniprotkb:O19615|uniprotkb:O19624|uniprotkb:O78163|uniprotkb:O78172|intact:EBI-1054175|uniprotkb:O19625|uniprotkb:O19627|uniprotkb:O19641|uniprotkb:O19651|uniprotkb:O19675|uniprotkb:O19692|uniprotkb:O19758|uniprotkb:O19779|uniprotkb:O19783|uniprotkb:O46702|uniprotkb:O62897|uniprotkb:O62915|uniprotkb:O62917|uniprotkb:O62919|uniprotkb:O77933|uniprotkb:O77959|uniprotkb:O78053|uniprotkb:O78138|uniprotkb:O78160|uniprotkb:O78173|uniprotkb:O78180|uniprotkb:O78217|uniprotkb:P01890|uniprotkb:P03989|uniprotkb:P10317|uniprotkb:P10318|uniprotkb:P10319|uniprotkb:P10320|uniprotkb:P18463|uniprotkb:P18464|uniprotkb:P18465|uniprotkb:P19373|uniprotkb:P30460|uniprotkb:P30461|uniprotkb:P30462|uniprotkb:P30463|uniprotkb:P30464|uniprotkb:P30465|uniprotkb:P30466|uniprotkb:P30467|uniprotkb:P30468|uniprotkb:P30469|uniprotkb:P30470|uniprotkb:P30471|uniprotkb:P30472|uniprotkb:P30473|uniprotkb:P30474|uniprotkb:P30475|uniprotkb:P30476|uniprotkb:P30477|uniprotkb:P30478|uniprotkb:P30479|uniprotkb:P30480|uniprotkb:P30481|uniprotkb:Q29693|uniprotkb:Q29695|uniprotkb:Q29697|uniprotkb:Q29718|uniprotkb:Q29742|uniprotkb:Q29749|uniprotkb:Q29762|uniprotkb:Q29764|uniprotkb:Q29829|uniprotkb:Q29836|uniprotkb:Q29842|uniprotkb:Q29845|uniprotkb:Q29846|uniprotkb:Q29847|uniprotkb:Q29848|uniprotkb:Q29850|uniprotkb:Q29851|uniprotkb:Q29852|uniprotkb:P30482|uniprotkb:P30483|uniprotkb:P30484|uniprotkb:P30485|uniprotkb:P30486|uniprotkb:P30487|uniprotkb:P30488|uniprotkb:P30489|uniprotkb:P30490|uniprotkb:P30491|uniprotkb:P30492|uniprotkb:P30493|uniprotkb:P30494|uniprotkb:P30495|uniprotkb:P30496|uniprotkb:P30497|uniprotkb:P30498|uniprotkb:P30513|uniprotkb:P30685|uniprotkb:P79489|uniprotkb:P79490|uniprotkb:P79496|uniprotkb:P79504|uniprotkb:P79523|uniprotkb:P79524|uniprotkb:P79555|uniprotkb:Q04826|uniprotkb:Q08136|uniprotkb:Q29633|uniprotkb:Q29636|uniprotkb:Q29638|uniprotkb:Q29661|uniprotkb:Q29665|uniprotkb:Q29678|uniprotkb:Q29679|uniprotkb:Q29681|uniprotkb:Q29935|uniprotkb:Q29936|uniprotkb:Q29940|uniprotkb:Q29953|uniprotkb:Q29961|uniprotkb:Q29982|intact:EBI-4289931|intact:EBI-7382650|intact:MINT-144207|intact:EBI-7245379|intact:MINT-1195012|intact:EBI-1059117|intact:EBI-4289845|uniprotkb:Q29854|uniprotkb:Q29855|uniprotkb:Q29857|uniprotkb:Q29858|uniprotkb:Q29861|uniprotkb:Q29924|uniprotkb:Q29925|uniprotkb:Q29933|uniprotkb:Q8MHN4|uniprotkb:Q30173|uniprotkb:Q30198|uniprotkb:Q31603|uniprotkb:Q31610|uniprotkb:Q31612|uniprotkb:Q31613|uniprotkb:Q546L8|uniprotkb:Q546M4|uniprotkb:Q5JP37|uniprotkb:Q5QT24|uniprotkb:Q5RIP1|uniprotkb:Q5SRJ2|uniprotkb:Q5TK76|uniprotkb:Q5TK77|uniprotkb:Q860I4|uniprotkb:Q861B5|uniprotkb:Q8HWF0|uniprotkb:Q8MGQ3|uniprotkb:Q8SNC5|uniprotkb:Q95343|uniprotkb:Q95344|uniprotkb:Q95365|uniprotkb:Q95392|uniprotkb:Q95HA3|uniprotkb:Q95HA8|uniprotkb:Q95HM9|uniprotkb:Q95IA6|uniprotkb:Q95IB8|uniprotkb:Q95IH5|uniprotkb:Q96IT9|uniprotkb:Q9BCM6|uniprotkb:Q9BCM7|uniprotkb:Q9BCM8|uniprotkb:Q9BD06|uniprotkb:Q9BD38|uniprotkb:Q9BD43|uniprotkb:Q9GIL3|uniprotkb:Q9GIM3|uniprotkb:Q9GIX1|uniprotkb:Q9GIY5|uniprotkb:Q9GIZ0|uniprotkb:Q9GIZ9|uniprotkb:Q9GJ00|uniprotkb:Q9GJ17|uniprotkb:Q9GJ23|uniprotkb:Q9GJ31|uniprotkb:Q9GJF0|uniprotkb:Q9GJM7|uniprotkb:Q9MX21|uniprotkb:Q9MY37|uniprotkb:Q9MY42|uniprotkb:Q9MY43|uniprotkb:Q9MY61|uniprotkb:Q9MY75|uniprotkb:Q9MY79|uniprotkb:Q9MY84|uniprotkb:Q9MY92|uniprotkb:Q9MY93|uniprotkb:Q9MY94|uniprotkb:Q9MYB8|uniprotkb:Q9MYC3|uniprotkb:Q9MYC7|uniprotkb:Q9MYG1|uniprotkb:Q9TP35|uniprotkb:Q9UQS8|uniprotkb:Q9TP36|uniprotkb:Q9TP37|uniprotkb:Q9TP95|uniprotkb:Q9TPQ7|uniprotkb:Q9TPQ9|uniprotkb:Q9TPR2|uniprotkb:Q9TPR4|uniprotkb:Q9TPS6|uniprotkb:Q9TPT2|uniprotkb:Q9TPT4|uniprotkb:Q9TPT6|uniprotkb:Q9TPV2|uniprotkb:Q9TQG1|uniprotkb:Q9TQH3|uniprotkb:Q9TQH7|uniprotkb:Q9TQH8|uniprotkb:Q9TQH9|uniprotkb:Q9TQN4|uniprotkb:Q9TQN6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlab_human(display_long)|uniprotkb:Human leukocyte antigen B(gene name synonym)|uniprotkb:HLA-B(gene name)|psi-mi:HLA-B(display_short)|uniprotkb:HLAB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:2HJL|rcsb pdb:2NW3|rcsb pdb:2A83|rcsb pdb:2NX5|rcsb pdb:2RFX|rcsb pdb:2YPK|rcsb pdb:2YPL|rcsb pdb:3B3I|rcsb pdb:3B6S|rcsb pdb:3BP4|rcsb pdb:3BP7|rcsb pdb:3BW9|rcsb pdb:3BWA|rcsb pdb:3C9N|rcsb pdb:3CZF|rcsb pdb:3D18|rcsb pdb:3DTX|rcsb pdb:2AK4|rcsb pdb:3DX6|rcsb pdb:3DX7|rcsb pdb:2AXF|rcsb pdb:3DX8|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:3HCV|rcsb pdb:2AXG|rcsb pdb:2BSR|rcsb pdb:2BSS|rcsb pdb:2BST|rcsb pdb:2BVO|rcsb pdb:2BVP|rcsb pdb:2BVQ|rcsb pdb:3KPL|rcsb pdb:3KPM|rcsb pdb:3KPN|rcsb pdb:3KPO|rcsb pdb:3KPP|rcsb pdb:3KPQ|rcsb pdb:3KPR|rcsb pdb:3KPS|rcsb pdb:3KWW|rcsb pdb:3KXF|rcsb pdb:3L3D|rcsb pdb:2H6P|rcsb pdb:3L3G|rcsb pdb:3L3I|rcsb pdb:3L3J|rcsb pdb:3L3K|rcsb pdb:3LN5|rcsb pdb:3LV3|rcsb pdb:3MV7|rcsb pdb:3LKN|rcsb pdb:3LKO|rcsb pdb:3LKP|rcsb pdb:3MV8|rcsb pdb:3MV9|rcsb pdb:3SJV|rcsb pdb:3SKM|rcsb pdb:3SKO|rcsb pdb:3SPV|rcsb pdb:3UPR|rcsb pdb:3VCL|rcsb pdb:3VFS|rcsb pdb:3VFT|rcsb pdb:3VFU|rcsb pdb:3VFV|rcsb pdb:3VFW|rcsb pdb:3VH8|rcsb pdb:3VRI|rcsb pdb:3LKQ|rcsb pdb:3LKR|rcsb pdb:3LKS|rcsb pdb:3LN4|rcsb pdb:3VRJ|rcsb pdb:3W39|rcsb pdb:3WUW|rcsb pdb:3X11|rcsb pdb:3X12|rcsb pdb:3X13|rcsb pdb:3X14|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|interpro:IPR037055|rcsb pdb:1A1M|rcsb pdb:1A1N|interpro:IPR036179|rcsb pdb:1A1O|rcsb pdb:1A9B|rcsb pdb:1A9E|rcsb pdb:1AGB|rcsb pdb:1AGC|rcsb pdb:1AGD|rcsb pdb:1AGE|rcsb pdb:1AGF|rcsb pdb:1CG9|rcsb pdb:1E27|rcsb pdb:1E28|rcsb pdb:1HSA|rcsb pdb:1JGD|rcsb pdb:1JGE|rcsb pdb:1K5N|rcsb pdb:1M05|rcsb pdb:1M6O|rcsb pdb:1MI5|rcsb pdb:1N2R|rcsb pdb:1OF2|rcsb pdb:1OGT|rcsb pdb:1SYS|rcsb pdb:1SYV|rcsb pdb:1UXS|rcsb pdb:1UXW|rcsb pdb:1W0V|rcsb pdb:1W0W|rcsb pdb:1XH3|rcsb pdb:1XR8|rcsb pdb:1XR9|rcsb pdb:1ZHK|rcsb pdb:1ZHL|rcsb pdb:1ZSD|rcsb pdb:4JQV|rcsb pdb:4JQX|rcsb pdb:4LCY|rcsb pdb:4LNR|rcsb pdb:4MJI|rcsb pdb:4G9F|rcsb pdb:4O2C|rcsb pdb:4O2E|rcsb pdb:4O2F|rcsb pdb:4PR5|rcsb pdb:4PRN|rcsb pdb:4QRP|rcsb pdb:4QRQ|rcsb pdb:4QRR|rcsb pdb:4QRS|rcsb pdb:4QRT|rcsb pdb:4QRU|rcsb pdb:4U1H|rcsb pdb:4U1I|rcsb pdb:4U1J|rcsb pdb:4U1K|rcsb pdb:4U1L|rcsb pdb:4U1M|rcsb pdb:4U1N|rcsb pdb:4U1S|rcsb pdb:4XXC|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5DEF|rcsb pdb:5DEG|rcsb pdb:5EO0|rcsb pdb:5EO1|rcsb pdb:5IB1|rcsb pdb:5IB2|rcsb pdb:5IB3|rcsb pdb:5TXS|rcsb pdb:5U98|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5IB4|rcsb pdb:5IB5|rcsb pdb:5IEH|rcsb pdb:5VUD|rcsb pdb:5VUE|rcsb pdb:5IEK|rcsb pdb:5VUF|rcsb pdb:5VWD|rcsb pdb:5VWF|rcsb pdb:5VWH|rcsb pdb:5VWJ|rcsb pdb:5VZ5|rcsb pdb:5WMN|rcsb pdb:5WMO|rcsb pdb:5WMP|rcsb pdb:5IM7|rcsb pdb:5WMQ|rcsb pdb:5WMR|rcsb pdb:5XOS|rcsb pdb:5XOT|rcsb pdb:5INC|rcsb pdb:6AT5|rcsb pdb:6AVF|rcsb pdb:5IND|rcsb pdb:5T6W|rcsb pdb:6AVG|rcsb pdb:6BJ2|rcsb pdb:6BJ3|rcsb pdb:6BJ8|rcsb pdb:6BXP|rcsb pdb:5T6X|rcsb pdb:6BXQ|rcsb pdb:5T6Y|rcsb pdb:6D29|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6D2B|rcsb pdb:6D2R|rcsb pdb:6D2T|rcsb pdb:6MT3|rcsb pdb:6MT4|rcsb pdb:6MT5|rcsb pdb:6MT6|ensembl:ENSG00000234745(gene)|ensembl:ENST00000412585(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2001198"(regulation of dendritic cell differentiation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:6MTM|rcsb pdb:6P23|rcsb pdb:6P27|rcsb pdb:6P2C|rcsb pdb:6P2F|rcsb pdb:6P2S|rcsb pdb:6PYJ|rcsb pdb:6PYL|rcsb pdb:6PYV|rcsb pdb:6PYW|rcsb pdb:6PZ5|rcsb pdb:6UJ7|rcsb pdb:6UJ8|rcsb pdb:6UJ9|rcsb pdb:6VMX|rcsb pdb:7LFZ|rcsb pdb:7LG0|rcsb pdb:7LGD|rcsb pdb:7LGT|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6MTL|refseq:NP_005505.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:NlO2PZ/66RypUzj8Euht3hRq8H89606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P27824 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBS4 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174316|imex:IM-17346-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:213AE67A87EADC94|rigid:iQkr/KcEB05IWpFD8cXJ3JiYtL0 false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O94919 intact:EBI-6179711 intact:EBI-6163734|ensembl:ENSP00000278505|uniprotkb:Q8TAQ8|uniprotkb:Q6GQY5|uniprotkb:A8K6K8 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:endd1_human(display_long)|uniprotkb:ENDOD1(gene name)|psi-mi:ENDOD1(display_short)|uniprotkb:KIAA0830(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000149218(gene)|ensembl:ENST00000278505(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|interpro:IPR039015|reactome:R-HSA-114608|refseq:NP_055851.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Y1gEFK1zb6sij3QwLSrq9t4zQLU9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q8N4V1 intact:EBI-6179711 intact:EBI-6163737|ensembl:ENSP00000306220|ensembl:ENSP00000505226|uniprotkb:B2R625|uniprotkb:B4DIY3|uniprotkb:D3DWG7|uniprotkb:Q5JPP7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:emc5_human(display_long)|uniprotkb:MMGT1(gene name)|psi-mi:MMGT1(display_short)|uniprotkb:TMEM32(gene name synonym)|uniprotkb:Transmembrane protein 32(gene name synonym)|uniprotkb:EMC5(gene name synonym)|uniprotkb:Membrane magnesium transporter 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0015693"(magnesium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022890"(inorganic cation transmembrane transporter activity)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072546"(EMC complex)|interpro:IPR018937|rcsb pdb:6WW7|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|reactome:R-HSA-5223345|ensembl:ENSG00000169446(gene)|ensembl:ENST00000305963(transcript)|ensembl:ENST00000679621(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|refseq:NP_775741.1|refseq:NP_001316929.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Kq+VEYt+fwoOsEfcgZ1K1vkFFN49606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P20674 intact:EBI-6179711 intact:EBI-715032|uniprotkb:P30045|intact:EBI-1043629|uniprotkb:Q8TB65|ensembl:ENSP00000317780|ensembl:ENSP00000456386 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cox5a_human(display_long)|uniprotkb:Cytochrome c oxidase polypeptide Va(gene name synonym)|uniprotkb:COX5A(gene name)|psi-mi:COX5A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_004246.2|interpro:IPR003204(Cytochrome c oxidase, subunit Va)|interpro:IPR036545|mint:P20674|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|go:"GO:0046872"(metal ion binding)|ensembl:ENSG00000178741(gene)|ensembl:ENST00000322347(transcript)|ensembl:ENST00000564811(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0009055"(electron transfer activity) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:dWvZKYawyJQwN29Mhkm44DXXqhg9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P35232 intact:EBI-6179711 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9UBV2 intact:EBI-6179711 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9UJZ1 intact:EBI-6179711 intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q8IYS2 intact:EBI-6179711 intact:EBI-2866116|uniprotkb:Q8IVF8|uniprotkb:Q8NDI7|uniprotkb:Q5JXC1|uniprotkb:Q9BSY1|ensembl:ENSP00000365756|ensembl:ENSP00000480577 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:k2013_human(display_long)|uniprotkb:KIAA2013(gene name)|psi-mi:KIAA2013(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_612355.1|refseq:XP_005263588.1|ensembl:ENSG00000116685(gene)|ensembl:ENST00000376572(transcript)|ensembl:ENST00000616327(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|mint:Q8IYS2|interpro:IPR018795 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:c98fgl75bIy0X3/+3fN4cVTgDY09606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9NRD1 intact:EBI-6179711 intact:EBI-3938499|uniprotkb:B1AK42|uniprotkb:Q9UKT3|uniprotkb:B2RC88|intact:EBI-28977383|ensembl:ENSP00000365944 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:fbx6_human(display_long)|uniprotkb:FBXO6(gene name)|psi-mi:FBXO6(display_short)|uniprotkb:FBG2(gene name synonym)|uniprotkb:FBS2(gene name synonym)|uniprotkb:FBX6(gene name synonym)|uniprotkb:F-box protein that recognizes sugar chains 2(gene name synonym)|uniprotkb:F-box/G-domain protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSP00000365944|refseq:XP_011539534.1|ensembl:ENSG00000116663(gene)|ensembl:ENST00000376753(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006508"(proteolysis)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036047|interpro:IPR039752|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_060908.1|refseq:XP_005263505.1|refseq:XP_005263506.1|refseq:XP_005263508.1|refseq:XP_006710634.1|refseq:XP_016856496.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:I4V9ZtDHo7W175sn3w8efv1DhsE9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y277 intact:EBI-6179711 intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P13073 intact:EBI-6179711 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96DZ1 intact:EBI-6179711 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q99623 intact:EBI-6179711 intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:h4pib54mBeQgOKCe/hib58LM26w9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q12907 intact:EBI-6179711 intact:EBI-3915406|uniprotkb:Q53HH1|ensembl:ENSP00000303366 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman2_human(display_long)|uniprotkb:LMAN2(gene name)|psi-mi:LMAN2(display_short)|uniprotkb:C5orf8(gene name synonym)|uniprotkb:Glycoprotein GP36b(gene name synonym)|uniprotkb:Lectin mannose-binding 2(gene name synonym)|uniprotkb:Vesicular integral-membrane protein 36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006807.1|ensembl:ENSG00000169223(gene)|ensembl:ENST00000303127(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035664|mint:Q12907|reactome:R-HSA-204005|reactome:R-HSA-5694530 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:goqUZGW9/lvVMWDAZS9csH3TqWY9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P30101 intact:EBI-6179711 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9NYU2 intact:EBI-6179711 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O96008 intact:EBI-6179711 intact:EBI-1057581|uniprotkb:Q86VW4|uniprotkb:Q8WY09|uniprotkb:Q8WY10|uniprotkb:Q8WY11|uniprotkb:Q9BR95|uniprotkb:A0A024R0P9|ensembl:ENSP00000252487|ensembl:ENSP00000385184|ensembl:ENSP00000410339 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tom40_human(display_long)|uniprotkb:TOMM40(gene name)|psi-mi:TOMM40(display_short)|uniprotkb:PEREC1(gene name synonym)|uniprotkb:TOM40(gene name synonym)|uniprotkb:C19orf1(gene name synonym)|uniprotkb:Translocase of outer membrane 40 kDa subunit homolog(gene name synonym)|uniprotkb:Protein Haymaker(gene name synonym)|uniprotkb:p38.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001122388.1|refseq:NP_001122389.1|refseq:NP_006105.1|ensembl:ENSG00000130204(gene)|ensembl:ENST00000252487(transcript)|ensembl:ENST00000405636(transcript)|ensembl:ENST00000426677(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006811"(ion transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0046930"(pore complex)|interpro:IPR023614|interpro:IPR027246|interpro:IPR037930|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685|go:"GO:0005741"(mitochondrial outer membrane) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:BBV//Cb2ekmDNGHNrZuAXRgS++Y9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P21796 intact:EBI-6179711 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q13162 intact:EBI-6179711 intact:EBI-2211957|uniprotkb:Q6FHT3|ensembl:ENSP00000368646 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:prdx4_human(display_long)|uniprotkb:PRDX4(gene name)|psi-mi:PRDX4(display_short)|uniprotkb:Peroxiredoxin IV(gene name synonym)|uniprotkb:Thioredoxin peroxidase AO372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase A0372(gene name synonym)|uniprotkb:Antioxidant enzyme AOE372(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006397.1|ensembl:ENSG00000123131(gene)|ensembl:ENST00000379341(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0008584"(male gonad development)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000255"(negative regulation of male germ cell proliferation)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR036249|mint:Q13162|rcsb pdb:2PN8|rcsb pdb:3TJB|rcsb pdb:3TJF|rcsb pdb:3TJG|rcsb pdb:3TJJ|rcsb pdb:3TJK|rcsb pdb:3TKP|rcsb pdb:3TKQ|rcsb pdb:3TKR|rcsb pdb:3TKS|rcsb pdb:4RQX|rcsb pdb:5HQP|reactome:R-HSA-6798695 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:5KWl3YuUpRDrSUxWlJS6sP7CLAs9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O96000 intact:EBI-6179711 intact:EBI-1246371|uniprotkb:Q96II6|ensembl:ENSP00000268668 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:nduba_human(display_long)|uniprotkb:NDUFB10(gene name)|psi-mi:NDUFB10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase PDSW subunit(gene name synonym)|uniprotkb:Complex I-PDSW(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_004539.1|ensembl:ENSG00000140990(gene)|ensembl:ENST00000268668(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|interpro:IPR019377|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR039993|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|dip:DIP-38298N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CRQJLj/I1jZSnIU7GeuRDGN4hRA9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P55072 intact:EBI-6179711 intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q8NBS9 intact:EBI-6179711 intact:EBI-2510815|ensembl:ENSP00000369081|uniprotkb:Q8TCT2|uniprotkb:Q5TCQ0|uniprotkb:Q9BVH9|uniprotkb:Q8ND33|uniprotkb:B2RDM2 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:txnd5_human(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|rcsb pdb:2DIZ|rcsb pdb:3UJ1|rcsb pdb:3UVT|rcsb pdb:3WGD|rcsb pdb:3WGE|rcsb pdb:3WGX|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001139021.1|refseq:NP_110437.2|dip:DIP-53700N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:bz5VVWMPFLTRKwph60UFASjsFN49606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P49257 intact:EBI-6179711 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P45880 intact:EBI-6179711 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q07065 intact:EBI-6179711 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O15162 intact:EBI-6179711 intact:EBI-740019|ensembl:ENSP00000345494|uniprotkb:B2R8H8|uniprotkb:B4DTE8 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pls1_human(display_long)|uniprotkb:PLSCR1(gene name)|psi-mi:PLSCR1(display_short)|uniprotkb:"Ca(2+)-dependent phospholipid scramblase 1"(gene name synonym)|uniprotkb:Erythrocyte phospholipid scramblase(gene name synonym)|uniprotkb:MmTRA1b(gene name synonym)|uniprotkb:"Mg(2+)-dependent nuclease"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000188313(gene)|ensembl:ENST00000342435(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001618"(virus receptor activity)|go:"GO:0003677"(DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006659"(phosphatidylserine biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0017124"(SH3 domain binding)|ensembl:ENSP00000345494|ensembl:ENST00000448787|ensembl:ENSP00000411675|refseq:NP_066928.1|go:"GO:0017128"(phospholipid scramblase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0032791"(lead ion binding)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051607"(defense response to virus)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070782"(phosphatidylserine exposure on apoptotic cell surface)|go:"GO:1905820"(positive regulation of chromosome separation)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR005552(Scramblase)|mint:O15162|rcsb pdb:1Y2A|refseq:XP_011511209.1|refseq:XP_011511206.1|refseq:XP_005247595.1|refseq:XP_011511208.1|refseq:XP_016862118.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:XudfvUkrZbB28t9tpFkokgnDFGc9606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P14854 intact:EBI-6179711 intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174459|imex:IM-17346-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606 intact-crc:1ECF5F0987890A2D|rigid:nIY1CjVTZ+oCbvr6geFjIalo+GA false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q7Z4H3 intact:EBI-6248077 intact:EBI-6163836|ensembl:ENSP00000381220|uniprotkb:Q5TDQ4|uniprotkb:Q6NZ49|uniprotkb:Q9BTT2|uniprotkb:Q9BV31|uniprotkb:Q9Y3D1 psi-mi:q76353_9hiv1(display_long) psi-mi:hddc2_human(display_long)|uniprotkb:CGI-130(orf name)|uniprotkb:HDDC2(gene name)|psi-mi:HDDC2(display_short)|uniprotkb:C6orf74(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 2(gene name synonym)|uniprotkb:NS5ATP2(gene name synonym)|uniprotkb:HD domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR039356|rcsb pdb:4DMB|rcsb pdb:4L1J|rcsb pdb:4L7E|rcsb pdb:4L7W|ensembl:ENSG00000111906(gene)|ensembl:ENST00000398153(transcript)|go:"GO:0002953"(5'-deoxynucleotidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|refseq:NP_057147.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:8f3lTUUoG5pAau6LGaxmi1qS6lU9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P15924 intact:EBI-6248077 intact:EBI-355041|uniprotkb:O75993|uniprotkb:Q14189|uniprotkb:Q9UHN4|uniprotkb:B2RTT2|uniprotkb:D7RX09|ensembl:ENSP00000369129 psi-mi:q76353_9hiv1(display_long) psi-mi:desp_human(display_long)|uniprotkb:DSP(gene name)|psi-mi:DSP(display_short)|uniprotkb:250/210 kDa paraneoplastic pemphigus antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001305963.1|refseq:NP_001008844.1|refseq:NP_004406.2|go:"GO:0014704"(intercalated disc)|go:"GO:0005916"(fascia adherens)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|ensembl:ENSG00000096696(gene)|ensembl:ENST00000379802(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:P15924|rcsb pdb:1LM5|rcsb pdb:1LM7|rcsb pdb:3R6N|rcsb pdb:5DZZ|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696273|dip:DIP-109N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:enapEqSoyTSLfPEQUAopkGpdxbo9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q14566 intact:EBI-6248077 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:q76353_9hiv1(display_long) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P31946 intact:EBI-6248077 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:q76353_9hiv1(display_long) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9Y3D0 intact:EBI-6248077 intact:EBI-744045|ensembl:ENSP00000387471 psi-mi:q76353_9hiv1(display_long) psi-mi:cia2b_human(display_long)|uniprotkb:CIAO2B(gene name)|psi-mi:CIAO2B(display_short)|uniprotkb:CIAB(gene name synonym)|uniprotkb:FAM96B(gene name synonym)|uniprotkb:MIP18(gene name synonym)|uniprotkb:MSS19-interacting protein of 18 kDa(gene name synonym)|uniprotkb:Mitotic spindle-associated MMXD complex subunit MIP18(gene name synonym)|uniprotkb:Protein FAM96B(gene name synonym)|uniprotkb:CGI-128(orf name)|uniprotkb:HSPC118(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_057146.1|ensembl:ENSG00000166595(gene)|ensembl:ENST00000422424(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030496"(midbody)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002744(Protein of unknown function DUF59)|interpro:IPR034904|interpro:IPR039796|mint:Q9Y3D0|reactome:R-HSA-2564830 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:6LfOUjTAKuEjop3XVyyxx6c4Wl09606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:O75155 intact:EBI-6248077 intact:EBI-5656182|uniprotkb:B9EGM9|uniprotkb:E9KL24|ensembl:ENSP00000387641 psi-mi:q76353_9hiv1(display_long) psi-mi:cand2_human(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 2(gene name synonym)|uniprotkb:KIAA0667(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa B(gene name synonym)|uniprotkb:TIP120B(gene name synonym)|uniprotkb:p120 CAND2(gene name synonym)|uniprotkb:CAND2(gene name)|psi-mi:CAND2(display_short)|uniprotkb:Epididymis tissue protein Li 169(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001155971.1|refseq:NP_036430.1|ensembl:ENSG00000144712(gene)|ensembl:ENST00000456430(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:O75155 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:LKo/B25pZVSPOAE+Yvk/ug1o7xY9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P61981 intact:EBI-6248077 intact:EBI-359832|uniprotkb:O70457|uniprotkb:P35214|uniprotkb:Q6FH52|uniprotkb:Q9UDP2|uniprotkb:Q9UN99|ensembl:ENSP00000306330 psi-mi:q76353_9hiv1(display_long) psi-mi:1433g_human(display_long)|uniprotkb:YWHAG(gene name)|psi-mi:YWHAG(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_036611.2|ensembl:ENSG00000170027(gene)|ensembl:ENST00000307630(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006605"(protein targeting)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098793"(presynapse)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P61981|rcsb pdb:2B05|rcsb pdb:3UZD|rcsb pdb:4E2E|rcsb pdb:4J6S|rcsb pdb:4O46|rcsb pdb:5D3E|rcsb pdb:6A5S|rcsb pdb:6BYJ|rcsb pdb:6BYL|rcsb pdb:6BZD|rcsb pdb:6FEL|rcsb pdb:6GKF|rcsb pdb:6GKG|rcsb pdb:6S9K|rcsb pdb:6SAD|rcsb pdb:6Y4K|rcsb pdb:6Y6B|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-9614399|dip:DIP-33406N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:u1cd71h0RPgTOEMrQVhOelsxWnM9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P12532 intact:EBI-6248077 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:q76353_9hiv1(display_long) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:O00469 intact:EBI-6248077 intact:EBI-1047459|uniprotkb:Q59ED2|uniprotkb:Q8N170|intact:EBI-2559757|uniprotkb:B3KWS3|ensembl:ENSP00000353170 psi-mi:q76353_9hiv1(display_long) psi-mi:plod2_human(display_long)|uniprotkb:Lysyl hydroxylase 2(gene name synonym)|uniprotkb:PLOD2(gene name)|psi-mi:PLOD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_000926.2|refseq:NP_891988.1|ensembl:ENSG00000152952(gene)|ensembl:ENST00000360060(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0046947"(hydroxylysine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR029044|mint:O00469|reactome:R-HSA-1650814 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:sNgFtZzNoKBCz7KUhTBfMG/xxas9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P22314 intact:EBI-6248077 intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568 psi-mi:q76353_9hiv1(display_long) psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q8TEX9 intact:EBI-6248077 intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795 psi-mi:q76353_9hiv1(display_long) psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P63104 intact:EBI-6248077 intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465 psi-mi:q76353_9hiv1(display_long) psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q02809 intact:EBI-6248077 intact:EBI-357174|ensembl:ENSP00000196061|uniprotkb:Q96AV9|uniprotkb:Q9H132|uniprotkb:B4DR87|intact:EBI-21357524 psi-mi:q76353_9hiv1(display_long) psi-mi:plod1_human(display_long)|uniprotkb:PLOD(gene name synonym)|uniprotkb:PLOD1(gene name)|psi-mi:PLOD1(display_short)|uniprotkb:LLH(gene name synonym)|uniprotkb:Lysyl hydroxylase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENSG00000083444(gene)|ensembl:ENST00000196061(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005506"(iron ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008475"(procollagen-lysine 5-dioxygenase activity)|go:"GO:0008544"(epidermis development)|go:"GO:0017185"(peptidyl-lysine hydroxylation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902494"(catalytic complex)|interpro:IPR001006(Procollagen-lysine 5-dioxygenase)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR029044|mint:Q02809|reactome:R-HSA-1650814|refseq:NP_000293.2|refseq:NP_001303249.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:q0eJHb8L3qTbN1PnjQ8L0PcpOLw9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9P2R7 intact:EBI-6248077 intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987 psi-mi:q76353_9hiv1(display_long) psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P62258 intact:EBI-6248077 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:q76353_9hiv1(display_long) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9H583 intact:EBI-6248077 intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541 psi-mi:q76353_9hiv1(display_long) psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q2T9J0 intact:EBI-6248077 intact:EBI-2510623|ensembl:ENSP00000287078|uniprotkb:Q8N6H2|uniprotkb:Q5SQU1|uniprotkb:Q96AR5|uniprotkb:Q5SQT4 psi-mi:q76353_9hiv1(display_long) psi-mi:tysd1_human(display_long)|uniprotkb:TYSND1(gene name)|psi-mi:TYSND1(display_short)|uniprotkb:Trypsin domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENSG00000156521(gene)|ensembl:ENST00000287078(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0042802"(identical protein binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017345(Peptidase S1B, Tysnd1)|interpro:IPR039245|reactome:R-HSA-9033241|reactome:R-HSA-9033500|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001035363.1|refseq:NP_775826.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:nfBCzADhPAnpbY6GasKVCOaZjjs9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9Y263 intact:EBI-6248077 intact:EBI-1994037|uniprotkb:Q53EU5|uniprotkb:Q5VY33|uniprotkb:Q9NUL8|uniprotkb:Q9NVE9|uniprotkb:Q9UF53|uniprotkb:Q9Y5L1|ensembl:ENSP00000380460 psi-mi:q76353_9hiv1(display_long) psi-mi:plap_human(display_long)|uniprotkb:PLAA(gene name)|psi-mi:PLAA(display_short)|uniprotkb:PLAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001026859.1|ensembl:ENSG00000137055(gene)|ensembl:ENST00000397292(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|interpro:IPR038122|mint:Q9Y263|rcsb pdb:2K89|rcsb pdb:2K8A|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:3EBB psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:SoClA00UzZpX9vV1cJWvefY6eY89606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P13667 intact:EBI-6248077 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:q76353_9hiv1(display_long) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q8NEW0 intact:EBI-6248077 intact:EBI-1043569|uniprotkb:Q8TCH2|ensembl:ENSP00000350278|ensembl:ENSP00000359130|uniprotkb:B2R949|uniprotkb:D3DT61 psi-mi:q76353_9hiv1(display_long) psi-mi:znt7_human(display_long)|uniprotkb:SLC30A7(gene name)|psi-mi:SLC30A7(display_short)|uniprotkb:ZNT7(gene name synonym)|uniprotkb:ZNTL2(gene name synonym)|uniprotkb:Znt-like transporter 2(gene name synonym)|uniprotkb:Solute carrier family 30 member 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENSG00000162695(gene)|ensembl:ENST00000357650(transcript)|ensembl:ENST00000370112(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006829"(zinc ion transport)|go:"GO:0008324"(cation transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-264876|reactome:R-HSA-435368|go:"GO:0032119"(sequestering of zinc ion)|refseq:NP_001138356.1|refseq:NP_598003.2|refseq:XP_016855889.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:/okPwOjluCDoM8a5uHoixAyRc8E9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:O60518 intact:EBI-6248077 intact:EBI-1055771|uniprotkb:Q5T7X4|uniprotkb:Q7Z3V2|uniprotkb:Q96E78|ensembl:ENSP00000259569 psi-mi:q76353_9hiv1(display_long) psi-mi:rnbp6_human(display_long)|uniprotkb:RANBP6(gene name)|psi-mi:RANBP6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_036548.1|refseq:NP_001230131.1|refseq:NP_001230132.1|ensembl:ENSG00000137040(gene)|ensembl:ENST00000259569(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|interpro:IPR041389|interpro:IPR041653|mint:O60518 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:3yh3vq2Bj+aqE9zWUU9LET7en6g9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9GZS3 intact:EBI-6248077 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:q76353_9hiv1(display_long) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9H3U1 intact:EBI-6248077 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 psi-mi:q76353_9hiv1(display_long) psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174552|imex:IM-17346-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 intact-crc:E6AE247C0F537F8E|rigid:NHhX75rmoLtDBvp3uy6CEeDN5ow false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:B9A2Q4 intact:EBI-6179719 intact:EBI-6163452 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:b9a2q4_9hiv1(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR010999(Retroviral matrix, N-terminal)|go:"GO:0005198"(structural molecule activity) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.98 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:HiVsvI33mo4Sy3bmI3HWAKtzCZQ11676 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9HD40 intact:EBI-6179719 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P07814 intact:EBI-6179719 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P14868 intact:EBI-6179719 intact:EBI-358730|uniprotkb:Q2TNI3|uniprotkb:Q32Q69|uniprotkb:Q53HV4|uniprotkb:Q53YC5|uniprotkb:Q9BW52|uniprotkb:Q68CR9|uniprotkb:A8K3J2|uniprotkb:D3DP77|ensembl:ENSP00000264161 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sydc_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 40 protein(gene name synonym)|uniprotkb:DARS(gene name synonym)|uniprotkb:PIG40(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001340.2|refseq:NP_001280241.1|ensembl:ENSG00000115866(gene)|ensembl:ENST00000264161(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P14868|rcsb pdb:4J15|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Yzpil/THkSHGR/ixVyQbV3RZz/E9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q96I59 intact:EBI-6179719 intact:EBI-5455236|uniprotkb:G3V178|ensembl:ENSP00000281038 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:synm_human(display_long)|uniprotkb:NARS2(gene name)|psi-mi:NARS2(display_short)|uniprotkb:Asparaginyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_078954.4|refseq:NP_001230180.1|refseq:XP_016873792.1|ensembl:ENSG00000137513(gene)|ensembl:ENST00000281038(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004816"(asparagine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006421"(asparaginyl-tRNA aminoacylation)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004522(Asparaginyl-tRNA synthetase, class IIb)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-HSA-379726 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:8r61DYTijthPntztWKOxzbklcPY9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q12904 intact:EBI-6179719 intact:EBI-1045802|uniprotkb:Q6FG28|uniprotkb:Q96CQ9|uniprotkb:B4E1S7|uniprotkb:B3KTR2|ensembl:ENSP00000350699|ensembl:ENSP00000499850|ensembl:ENSP00000499921|ensembl:ENSP00000500025|ensembl:ENSP00000500159|ensembl:ENSP00000500170|ensembl:ENSP00000500620|ensembl:ENSP00000500668|ensembl:ENSP00000500732|ensembl:ENSP00000500794 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:aimp1_human(display_long)|uniprotkb:AIMP1(gene name)|psi-mi:AIMP1(display_short)|uniprotkb:EMAP2(gene name synonym)|uniprotkb:SCYE1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001135887.1|refseq:NP_001135888.1|refseq:NP_004748.2|ensembl:ENSG00000164022(gene)|ensembl:ENST00000358008(transcript)|ensembl:ENST00000671868(transcript)|ensembl:ENST00000671960(transcript)|ensembl:ENST00000672285(transcript)|ensembl:ENST00000672328(transcript)|ensembl:ENST00000672337(transcript)|ensembl:ENST00000672341(transcript)|ensembl:ENST00000672911(transcript)|ensembl:ENST00000673018(transcript)|ensembl:ENST00000673123(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051020"(GTPase binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070094"(positive regulation of glucagon secretion)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q12904|rcsb pdb:1E7Z|rcsb pdb:1EUJ|rcsb pdb:1FL0|rcsb pdb:4R3Z|reactome:R-HSA-2408522|reactome:R-HSA-379716|refseq:XP_016864324.1|refseq:XP_016864325.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:UtCeSRjFyuuEHUxVF2HkG9RA55k9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P26639 intact:EBI-6179719 intact:EBI-1042683|uniprotkb:Q96FP5|uniprotkb:Q9BWA6|uniprotkb:A8K8I1|ensembl:ENSP00000265112|ensembl:ENSP00000424387|uniprotkb:B4DEG8 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sytc_human(display_long)|uniprotkb:TARS1(gene name)|psi-mi:TARS1(display_short)|uniprotkb:TARS(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_689508.3|refseq:NP_001245367.1|rcsb pdb:4HWT|rcsb pdb:4P3N|rcsb pdb:4TTV|rcsb pdb:5XLN|reactome:R-HSA-379716|refseq:NP_001245366.1|go:"GO:0005829"(cytosol)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|ensembl:ENSG00000113407(gene)|interpro:IPR012676(TGS-like)|ensembl:ENST00000265112(transcript)|ensembl:ENST00000502553(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|mint:P26639|rcsb pdb:1WWT psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Z+rOaI1ZO1TQftfkRn1HhXUqDAk9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9NTK5 intact:EBI-6179719 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q15046 intact:EBI-6179719 intact:EBI-356367|uniprotkb:A8MSK1|uniprotkb:Q9HB23|uniprotkb:O14946|uniprotkb:Q96J25|ensembl:ENSP00000303043|uniprotkb:D3DUK4 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syk_human(display_long)|uniprotkb:KARS1(gene name)|psi-mi:KARS1(display_short)|uniprotkb:KARS(gene name synonym)|uniprotkb:KIAA0070(gene name synonym)|uniprotkb:Lysyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001123561.1|refseq:NP_005539.1|go:"GO:0016597"(amino acid binding)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0005739"(mitochondrion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|interpro:IPR002313(Lysyl-tRNA synthetase, class II)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018149|go:"GO:0005759"(mitochondrial matrix)|interpro:IPR034762|interpro:IPR044136|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|mint:Q15046|go:"GO:0006430"(lysyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|rcsb pdb:3BJU|rcsb pdb:4DPG|go:"GO:0010165"(response to X-ray)|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:6CHD|rcsb pdb:6ILD|rcsb pdb:6ILH|rcsb pdb:7EA9|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|ensembl:ENSG00000065427(gene)|ensembl:ENST00000302445(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002276"(basophil activation involved in immune response)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0003877"(ATP adenylyltransferase activity)|go:"GO:0004824"(lysine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|dip:DIP-29725N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:YLjIdoUW7DiNp+Pj1OPg8jhnC5w9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P56192 intact:EBI-6179719 intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P49590 intact:EBI-6179719 intact:EBI-3909030|uniprotkb:B4DDY8|intact:EBI-10988212|ensembl:ENSP00000230771|ensembl:ENSP00000494296 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syhm_human(display_long)|uniprotkb:Histidyl-tRNA synthetase(gene name synonym)|uniprotkb:HARS2(gene name)|psi-mi:HARS2(display_short)|uniprotkb:HARSL(gene name synonym)|uniprotkb:HARSR(gene name synonym)|uniprotkb:HO3(gene name synonym)|uniprotkb:Histidine--tRNA ligase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_036340.1|refseq:NP_001265660.1|refseq:NP_001265661.1|ensembl:ENSG00000112855(gene)|ensembl:ENST00000230771(transcript)|ensembl:ENST00000645749(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004821"(histidine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006427"(histidyl-tRNA aminoacylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004516(Histidyl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR015807(Histidyl-tRNA synthetase, class IIa, subgroup)|interpro:IPR033656|interpro:IPR036621|interpro:IPR041715|reactome:R-HSA-379726|go:"GO:0006412"(translation)|dip:DIP-59626N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:pp4g+OJKxW3va88iXtfIAnGXMKw9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9P2J5 intact:EBI-6179719 intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q13155 intact:EBI-6179719 intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q86SQ7 intact:EBI-6179719 intact:EBI-1047850|uniprotkb:Q3ZCR6|uniprotkb:Q8N5F2|uniprotkb:Q9P0F1|uniprotkb:O60527|ensembl:ENSP00000355499|ensembl:ENSP00000483550 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sdcg8_human(display_long)|uniprotkb:Antigen NY-CO-8(gene name synonym)|uniprotkb:Centrosomal colon cancer autoantigen protein(gene name synonym)|uniprotkb:SDCCAG8(gene name)|psi-mi:SDCCAG8(display_short)|uniprotkb:CCCAP(gene name synonym)|uniprotkb:NPHP10(gene name synonym)|uniprotkb:HSPC085(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_006633.1|ensembl:ENSG00000054282(gene)|ensembl:ENSG00000276111(gene)|ensembl:ENST00000366541(transcript)|ensembl:ENST00000622598(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0097733"(photoreceptor cell cilium)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR031887|mint:Q86SQ7|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_005273080.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Z3ynDtbmAV7usLzKH+M3Ilf6Ebw9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P54136 intact:EBI-6179719 intact:EBI-355482|uniprotkb:Q9BWA1|uniprotkb:B2RBS9|uniprotkb:Q53GY4|intact:EBI-28985219|ensembl:ENSP00000231572 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syrc_human(display_long)|uniprotkb:RARS1(gene name)|psi-mi:RARS1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:RARS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_002878.2|ensembl:ENSG00000113643(gene)|ensembl:ENST00000231572(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:P54136|rcsb pdb:4Q2T|rcsb pdb:4Q2X|rcsb pdb:4Q2Y|rcsb pdb:4R3Z|rcsb pdb:4ZAJ|reactome:R-HSA-2408522|reactome:R-HSA-379716|ensembl:ENSP00000231572 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:oM9gWF1NucjgVjBFm4DcjmnQNCE9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P47897 intact:EBI-6179719 intact:EBI-347462|uniprotkb:B4DWJ2|ensembl:ENSP00000307567 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syq_human(display_long)|uniprotkb:QARS1(gene name)|psi-mi:QARS1(display_short)|uniprotkb:Glutaminyl-tRNA synthetase(gene name synonym)|uniprotkb:QARS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_005042.1|ensembl:ENSG00000172053(gene)|ensembl:ENST00000306125(transcript)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004514(Glutaminyl-tRNA synthetase, class Ic)|interpro:IPR007638(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 2)|interpro:IPR007639(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 1)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR042558|interpro:IPR042559|mint:P47897|rcsb pdb:4R3Z|rcsb pdb:4YE6|rcsb pdb:4YE8|rcsb pdb:4YE9|reactome:R-HSA-2408522|go:"GO:0006469"(negative regulation of protein kinase activity)|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0007420"(brain development)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001259002.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:3Q8LR+aWJJue/ixtD3ZYDpC/D3o9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:O43324 intact:EBI-6179719 intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:O00560 intact:EBI-6179719 intact:EBI-727004|uniprotkb:O43391|ensembl:ENSP00000260130|ensembl:ENSP00000411771|uniprotkb:O00173|uniprotkb:Q14CP2|uniprotkb:B4DUH3|uniprotkb:B7ZLN2|uniprotkb:B2R5Q7 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sdcb1_human(display_long)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 18(gene name synonym)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 9(gene name synonym)|uniprotkb:SDCBP(gene name)|psi-mi:SDCBP(display_short)|uniprotkb:MDA9(gene name synonym)|uniprotkb:SYCL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000137575(gene)|ensembl:ENST00000260130(transcript)|ensembl:ENST00000413219(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|refseq:NP_001007068.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|refseq:NP_001007069.1|refseq:NP_001007070.1|refseq:NP_001007071.1|refseq:NP_005616.2|go:"GO:0005925"(focal adhesion)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|go:"GO:0042802"(identical protein binding)|rcsb pdb:1N99|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:1NTE|go:"GO:0045121"(membrane raft)|rcsb pdb:1OBX|rcsb pdb:1OBY|rcsb pdb:1OBZ|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:1R6J|rcsb pdb:1V1T|rcsb pdb:1W9E|rcsb pdb:1W9O|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|rcsb pdb:1W9Q|rcsb pdb:1YBO|rcsb pdb:4Z33|rcsb pdb:6R9H|rcsb pdb:6RLC|reactome:R-HSA-3928664|reactome:R-HSA-447043|reactome:R-HSA-5213460|reactome:R-HSA-6798695|reactome:R-HSA-5675482|dip:DIP-42705N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Ys2RNVwH0n5AKA+rBULM9Foxccg9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P41252 intact:EBI-6179719 intact:EBI-355303|uniprotkb:Q5TCD0|uniprotkb:Q9H588|uniprotkb:A8KAE9|uniprotkb:Q7Z3T4|ensembl:ENSP00000364794|ensembl:ENSP00000406448|ensembl:ENSP00000507144 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syic_human(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short)|uniprotkb:IARS(gene name synonym)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174633|imex:IM-17346-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_002152.2|refseq:NP_038203.2|ensembl:ENSG00000196305(gene)|ensembl:ENST00000375643(transcript)|ensembl:ENST00000443024(transcript)|ensembl:ENST00000683565(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023586|interpro:IPR033709|mint:P41252|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:maAJX/O1Ryxr5NVFQEWvXNgHXyY9606 intact-crc:8C45A4911B4DD7CC|rigid:6wPjDMvTzLRUZ9/LMw1AhlsuNKU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:P13489 intact:EBI-6179727 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9Y3F4 intact:EBI-6179727 intact:EBI-727414|uniprotkb:Q9UQC8|uniprotkb:Q9NTK0|uniprotkb:Q5TZT4|intact:EBI-6190807|uniprotkb:B4DNJ6|uniprotkb:B2R5S5|ensembl:ENSP00000392270 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:strap_human(display_long)|uniprotkb:UNR-interacting protein(gene name synonym)|uniprotkb:WD-40 repeat protein PT-WD(gene name synonym)|uniprotkb:MAP activator with WD repeats(gene name synonym)|uniprotkb:STRAP(gene name)|psi-mi:STRAP(display_short)|uniprotkb:MAWD(gene name synonym)|uniprotkb:UNRIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_009109.3|ensembl:ENSG00000023734(gene)|ensembl:ENST00000419869(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:1990447"(U2 snRNP binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9Y3F4|reactome:R-HSA-2173788 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:/IqZt6BHPxD3S/THUZry4+QUvCE9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9Y3B7 intact:EBI-6179727 intact:EBI-5453723|ensembl:ENSP00000308897|uniprotkb:A8K219|uniprotkb:Q32P46|uniprotkb:Q96Q73|uniprotkb:A6NLT0 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:rm11_human(display_long)|uniprotkb:MRPL11(gene name)|psi-mi:MRPL11(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL11m(gene name synonym)|uniprotkb:CGI-113(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000174547(gene)|ensembl:ENST00000310999(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR006519(Ribosomal protein L11, bacterial-type)|interpro:IPR020783|interpro:IPR020784|interpro:IPR036769|interpro:IPR036796|mint:Q9Y3B7|refseq:NP_057134.1|refseq:NP_733934.1|refseq:NP_733935.1|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6NU3|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:eTr4vzze0vg1fxw97n9C/lXYssU9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q8N1G4 intact:EBI-6179727 intact:EBI-2509921|ensembl:ENSP00000367498|uniprotkb:Q9ULN5 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:lrc47_human(display_long)|uniprotkb:LRRC47(gene name)|psi-mi:LRRC47(display_short)|uniprotkb:KIAA1185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000130764(gene)|ensembl:ENST00000378251(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR025875|interpro:IPR032675|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|refseq:NP_065761.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:aPzU//EIwK8J4it97jCw/YyKFWU9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:O14974 intact:EBI-6179727 intact:EBI-351726|uniprotkb:Q2NKL4|uniprotkb:Q569H0|uniprotkb:Q86WU3|uniprotkb:Q8NFR6|uniprotkb:Q9BYH0|intact:EBI-28988491|uniprotkb:B4DZ09|uniprotkb:F8VWB4|ensembl:ENSP00000261207|ensembl:ENSP00000389168 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:mypt1_human(display_long)|uniprotkb:PPP1R12A(gene name)|psi-mi:PPP1R12A(display_short)|uniprotkb:MBS(gene name synonym)|uniprotkb:MYPT1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001137357.1|refseq:NP_001137358.1|refseq:NP_002471.1|refseq:NP_001231919.1|refseq:NP_001231921.1|refseq:XP_011536685.1|ensembl:ENSP00000261207|ensembl:ENST00000437004|ensembl:ENSP00000416769|ensembl:ENSP00000389168|ensembl:ENSP00000449514|ensembl:ENST00000550107|ensembl:ENSP00000446855|ensembl:ENST00000546369|dip:DIP-33186N|ensembl:ENSG00000058272(gene)|ensembl:ENST00000261207(transcript)|ensembl:ENST00000450142(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:O14974|rcsb pdb:2KJY|rcsb pdb:5HUZ|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:Xi5lGskc0tWQCHtbYlgR45ERMSk9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9UGY1 intact:EBI-6179727 intact:EBI-716098|ensembl:ENSP00000352021|ensembl:ENSP00000403059|ensembl:ENSP00000482349 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:nol12_human(display_long)|uniprotkb:NOL12(gene name)|psi-mi:NOL12(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_077289.1|ensembl:ENSG00000273899(gene)|ensembl:ENST00000359114(transcript)|ensembl:ENST00000438329(transcript)|ensembl:ENST00000611699(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0019843"(rRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR019186|reactome:R-HSA-6791226 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:yYrOadt76SuArmi4/Wfj2rFguNQ9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9UI30 intact:EBI-6179727 intact:EBI-373326|uniprotkb:Q3MHC7|uniprotkb:Q8N2Z4|uniprotkb:B2R539|uniprotkb:J3KNG5|ensembl:ENSP00000438349 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:tr112_human(display_long)|uniprotkb:tRNA methyltransferase 112 homolog(gene name synonym)|uniprotkb:AD-001(orf name)|uniprotkb:HSPC152(orf name)|uniprotkb:HSPC170(orf name)|uniprotkb:TRMT112(gene name)|psi-mi:TRMT112(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001273011.1|refseq:NP_057488.1|ensembl:ENSG00000173113(gene)|ensembl:ENST00000544844(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0018364"(peptidyl-glutamine methylation)|go:"GO:0030488"(tRNA methylation)|go:"GO:0031167"(rRNA methylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070476"("rRNA (guanine-N7)-methylation")|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR005651(Protein of unknown function DUF343)|mint:Q9UI30|rcsb pdb:6G4W|rcsb pdb:6H1D|rcsb pdb:6H1E|rcsb pdb:6H2U|rcsb pdb:6H2V|rcsb pdb:6K0X|rcsb pdb:6KHS|rcsb pdb:6KMR|rcsb pdb:6KMS|rcsb pdb:6PED|reactome:R-HSA-156581|reactome:R-HSA-6782315|reactome:R-HSA-6790901|reactome:R-HSA-72764|interpro:IPR039127 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:N3kvBRpRMFAeB5AYgOmAvs34u+c9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q99873 intact:EBI-6179727 intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q7Z739 intact:EBI-6179727 intact:EBI-2849837|uniprotkb:Q659A3|uniprotkb:B3KXL4|uniprotkb:Q63Z37|ensembl:ENSP00000473496 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ythd3_human(display_long)|uniprotkb:YTHDF3(gene name)|psi-mi:YTHDF3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_689971.4|refseq:NP_001264742.1|refseq:NP_001264743.1|refseq:NP_001264744.1|refseq:NP_001264745.1|refseq:NP_001264746.1|refseq:NP_001264747.1|ensembl:ENSG00000185728(gene)|ensembl:ENST00000539294(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1901163"(regulation of trophoblast cell migration)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q7Z739|rcsb pdb:6ZOT psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:M1/1RMOQiQ7kD+J9KMmEq9RZebw9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:O75534 intact:EBI-6179727 intact:EBI-719186|uniprotkb:O94961|uniprotkb:Q5TF04|uniprotkb:Q5TF05|uniprotkb:Q68DI9|uniprotkb:Q9Y2S4|uniprotkb:E9PGZ0|uniprotkb:Q68DF1|intact:EBI-1059183|ensembl:ENSP00000351329|ensembl:ENSP00000432958|uniprotkb:A8K281|uniprotkb:G5E9Q2 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:csde1_human(display_long)|uniprotkb:Protein UNR(gene name synonym)|uniprotkb:N-ras upstream gene protein(gene name synonym)|uniprotkb:CSDE1(gene name)|psi-mi:CSDE1(display_short)|uniprotkb:D1S155E(gene name synonym)|uniprotkb:KIAA0885(gene name synonym)|uniprotkb:NRU(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174702|imex:IM-17346-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001007554.1|refseq:NP_001123995.1|refseq:NP_001229820.1|refseq:NP_001229821.1|refseq:NP_001229822.1|refseq:NP_009089.4|ensembl:ENSG00000009307(gene)|ensembl:ENST00000358528(transcript)|ensembl:ENST00000534699(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008584"(male gonad development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0070937"(CRD-mediated mRNA stability complex)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR019844|interpro:IPR024642|mint:O75534|rcsb pdb:1WFQ|rcsb pdb:1X65|rcsb pdb:2YTV|rcsb pdb:2YTX|rcsb pdb:2YTY|interpro:IPR012340(Nucleic acid-binding, OB-fold) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:fpL1bONjNXyXjIO/akUIIoeEGTc9606 intact-crc:56A7F40F8F1B04BA|rigid:QaBoAFldz8EZYcfv6dGqLIUNpXY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P13995 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1058895|ensembl:ENSP00000377617|uniprotkb:Q7Z650|uniprotkb:Q53G90|uniprotkb:Q53GV5|uniprotkb:Q53S36 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:mtdc_human(display_long)|uniprotkb:MTHFD2(gene name)|psi-mi:MTHFD2(display_short)|uniprotkb:NMDMC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174744|imex:IM-17346-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 ensembl:ENSG00000065911(gene)|ensembl:ENST00000394053(transcript)|go:"GO:0000287"(magnesium ion binding)|rcsb pdb:1ZN4|rcsb pdb:5TC4|rcsb pdb:6JIB|rcsb pdb:6JID|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0046655"(folic acid metabolic process)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR036291|rcsb pdb:6KG2|refseq:XP_006711987.1|refseq:NP_006627.2|reactome:R-HSA-196757 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:dzNq2WEcKJ3DptZUIAnyKCITCsk9606 intact-crc:C891B360241F96F0|rigid:bS1WYb3YiONnech2vaM0DJTUQpw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:Q9NZJ7 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-297455|ensembl:ENSP00000362730|uniprotkb:Q6PK60|uniprotkb:Q6UX45|uniprotkb:Q7L465|uniprotkb:Q9BW23|uniprotkb:Q9NZR6|uniprotkb:Q9UJZ5|uniprotkb:B2RCE3|uniprotkb:A8KAX5 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:mtch1_human(display_long)|uniprotkb:Presenilin-associated protein(gene name synonym)|uniprotkb:CGI-64(orf name)|uniprotkb:MTCH1(gene name)|psi-mi:MTCH1(display_short)|uniprotkb:PSAP(gene name synonym)|uniprotkb:UNQ1871/PRO4314(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174744|imex:IM-17346-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 ensembl:ENSG00000137409(gene)|ensembl:ENST00000373627(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045161"(neuronal ion channel clustering)|interpro:IPR018108|interpro:IPR023395|mint:Q9NZJ7|refseq:NP_055156.1|refseq:NP_001258570.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:I0J5CxSiLB4OS6mhqwygLq389xY9606 intact-crc:C891B360241F96F0|rigid:bS1WYb3YiONnech2vaM0DJTUQpw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P31040 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1057265|uniprotkb:Q16395|uniprotkb:Q9UMY5|uniprotkb:B4DJ60|uniprotkb:E9PBJ5|uniprotkb:Q59GW8|uniprotkb:Q8IW48|uniprotkb:A8K5J6|ensembl:ENSP00000264932 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:sdha_human(display_long)|uniprotkb:SDHA(gene name)|psi-mi:SDHA(display_short)|uniprotkb:SDH2(gene name synonym)|uniprotkb:SDHF(gene name synonym)|uniprotkb:Flavoprotein subunit of complex II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174744|imex:IM-17346-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_001281261.1|refseq:NP_004159.2|ensembl:ENSG00000073578(gene)|ensembl:ENST00000264932(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006121"(mitochondrial electron transport, succinate to ubiquinone)|go:"GO:0007399"(nervous system development)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR003952(Fumarate reductase/succinate dehydrogenase, FAD-binding site)|interpro:IPR003953(Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal)|interpro:IPR011281(Succinate dehydrogenase, flavoprotein subunit)|interpro:IPR014006(Succinate dehydrogenase or fumarate reductase, flavoprotein subunit)|interpro:IPR015939(Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal)|interpro:IPR027477|interpro:IPR036188|interpro:IPR037099|rcsb pdb:6VAX|reactome:R-HSA-611105|reactome:R-HSA-71403|dip:DIP-45851N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:NfhgIzmcsvfPG1BP7tHcna+jTIY9606 intact-crc:C891B360241F96F0|rigid:bS1WYb3YiONnech2vaM0DJTUQpw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:O14734 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174744|imex:IM-17346-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606 intact-crc:C891B360241F96F0|rigid:bS1WYb3YiONnech2vaM0DJTUQpw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P30419 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-5280164|uniprotkb:A8K7C1|uniprotkb:Q9UE09|ensembl:ENSP00000258960|ensembl:ENSP00000468424|ensembl:ENSP00000504192 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:nmt1_human(display_long)|uniprotkb:NMT1(gene name)|psi-mi:NMT1(display_short)|uniprotkb:NMT(gene name synonym)|uniprotkb:"Myristoyl-CoA:protein N-myristoyltransferase 1"(gene name synonym)|uniprotkb:Peptide N-myristoyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174744|imex:IM-17346-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_066565.1|ensembl:ENSG00000136448(gene)|ensembl:ENST00000258960(transcript)|ensembl:ENST00000592782(transcript)|ensembl:ENST00000676828(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004379"(glycylpeptide N-tetradecanoyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0018008"(N-terminal peptidyl-glycine N-myristoylation)|go:"GO:0019107"(myristoyltransferase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0042180"(cellular ketone metabolic process)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR000903("Myristoyl-CoA:protein N-myristoyltransferase")|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR022676|interpro:IPR022677|interpro:IPR022678|rcsb pdb:1RXT|rcsb pdb:3IU1|rcsb pdb:3IU2|rcsb pdb:3IWE|rcsb pdb:3JTK|rcsb pdb:4C2Y|rcsb pdb:4C2Z|rcsb pdb:5MU6|rcsb pdb:5NPQ|rcsb pdb:5O6H|rcsb pdb:5O6J|rcsb pdb:5O9S|rcsb pdb:5O9T|rcsb pdb:5O9U|rcsb pdb:5O9V|rcsb pdb:5UUT|rcsb pdb:6EHJ|rcsb pdb:6F56|rcsb pdb:6FZ2|rcsb pdb:6FZ3|rcsb pdb:6FZ5|rcsb pdb:6PAV|rcsb pdb:6QRM|rcsb pdb:6SJZ|rcsb pdb:6SK2|rcsb pdb:6SK3|rcsb pdb:6SK8|rcsb pdb:6SKJ|reactome:R-HSA-162599|reactome:R-HSA-2514859|reactome:R-HSA-75108|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:eVkADRJp/cg4xIAw0ymeUZ+Vwyk9606 intact-crc:C891B360241F96F0|rigid:bS1WYb3YiONnech2vaM0DJTUQpw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P42771 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-375053|uniprotkb:O95440|uniprotkb:Q15191|uniprotkb:Q5VVJ5|uniprotkb:Q96B52|uniprotkb:Q9NP05|uniprotkb:A5X2G7|ensembl:ENSP00000307101|uniprotkb:D3DRK1|intact:EBI-7576126|intact:MINT-1344330|uniprotkb:G3XAG3 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:cdn2a_human(display_long)|uniprotkb:CDKN2A(gene name)|psi-mi:CDKN2A(display_short)|uniprotkb:CDKN2(gene name synonym)|uniprotkb:Cyclin-dependent kinase 4 inhibitor A(gene name synonym)|uniprotkb:p16-INK4a(gene name synonym)|uniprotkb:Multiple tumor suppressor 1(gene name synonym)|uniprotkb:MTS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174744|imex:IM-17346-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_000068.1|refseq:NP_478104.2|refseq:XP_011515981.1|ensembl:ENSG00000147889(gene)|ensembl:ENST00000304494(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003723"(RNA binding)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035985"(senescence-associated heterochromatin focus)|go:"GO:0035986"(obsolete senescence-associated heterochromatin focus assembly)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR036770|mint:P42771|rcsb pdb:1A5E|rcsb pdb:1BI7|rcsb pdb:1DC2|rcsb pdb:2A5E|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-69231|reactome:R-HSA-8853884|reactome:R-HSA-9630791|reactome:R-HSA-9630794|reactome:R-HSA-9632697|reactome:R-HSA-9632700|refseq:NP_001182061.1|refseq:XP_005251400.1|dip:DIP-6108N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:9qd+YTVorW7jBQB23jJuOuMUKCk9606 intact-crc:C891B360241F96F0|rigid:bS1WYb3YiONnech2vaM0DJTUQpw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UBQ5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O00303 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q99613 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P13667 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P46063 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2823728|uniprotkb:A8K6G2|ensembl:ENSP00000395449|ensembl:ENSP00000416739 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:recq1_human(display_long)|uniprotkb:RECQL(gene name)|psi-mi:RECQL(display_short)|uniprotkb:RECQ1(gene name synonym)|uniprotkb:RECQL1(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 1(gene name synonym)|uniprotkb:DNA-dependent ATPase Q1(gene name synonym)|uniprotkb:RecQ protein-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_002898.2|refseq:NP_116559.1|ensembl:ENSG00000004700(gene)|ensembl:ENST00000421138(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|mint:P46063|rcsb pdb:2V1X|rcsb pdb:2WWY|rcsb pdb:4U7D|rcsb pdb:6JTZ|ensembl:ENST00000444129(transcript)|refseq:XP_005253518.1|refseq:XP_005253519.1|refseq:XP_005253520.1|refseq:XP_005253521.1|dip:DIP-29216N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:zJXPLIWtbjvhAhWH0HN+qdkCCOg9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q14152 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y262 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q15293 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O75821 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366632|uniprotkb:O14801|uniprotkb:Q969U5|intact:EBI-28974438|ensembl:ENSP00000253108 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3g_human(display_long)|uniprotkb:EIF3G(gene name)|psi-mi:EIF3G(display_short)|uniprotkb:EIF3S4(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 4(gene name synonym)|uniprotkb:eIF-3-delta(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 RNA-binding subunit(gene name synonym)|uniprotkb:eIF3 p44(gene name synonym)|uniprotkb:eIF3 p42(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSP00000253108|refseq:NP_003746.2|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017334(Translation initiation factor 3, RNA-binding subunit)|interpro:IPR024675|interpro:IPR034240|interpro:IPR035979|mint:O75821|rcsb pdb:2CQ0|rcsb pdb:2MJC|rcsb pdb:5K0Y|rcsb pdb:6YBS|rcsb pdb:6ZMW|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|ensembl:ENSG00000130811(gene)|ensembl:ENST00000253108(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|dip:DIP-31115N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ZHm8Il08Zyb6kFAavZo4tnuUN4g9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q5T4S7 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:8Iown8oj965YAir+95+3om5+1YM9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9H4L5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15371 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q13347 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:fogC6nSNmIynV2ziHZboT9laA3M9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15372 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P55884 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q08380 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354956|ensembl:ENSP00000262776|uniprotkb:Q7M4S0|uniprotkb:Q9UCH8|uniprotkb:Q9UCH9|uniprotkb:Q9UCI0 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:lg3bp_human(display_long)|uniprotkb:LGALS3BP(gene name)|psi-mi:LGALS3BP(display_short)|uniprotkb:M2BP(gene name synonym)|uniprotkb:Lectin galactoside-binding soluble 3-binding protein(gene name synonym)|uniprotkb:Mac-2-binding protein(gene name synonym)|uniprotkb:Tumor-associated antigen 90K(gene name synonym)|uniprotkb:Basement membrane autoantigen p105(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000108679(gene)|ensembl:ENST00000262776(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR017448(Speract/scavenger receptor related)|go:"GO:0007155"(cell adhesion)|interpro:IPR036772|mint:Q08380|rcsb pdb:1BY2|rcsb pdb:6GFB|reactome:R-HSA-114608|refseq:NP_005558.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:1LIu+jrlwe2RGkR31frIXz8Ixec9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UMS0 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-725252|uniprotkb:Q53QE5|uniprotkb:Q6VNZ8|uniprotkb:Q7Z5B1|uniprotkb:Q7Z5B2|uniprotkb:Q9Y322|uniprotkb:B4DUL9|ensembl:ENSP00000387219 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:nfu1_human(display_long)|uniprotkb:HIRA-interacting protein 5(gene name synonym)|uniprotkb:NFU1(gene name)|psi-mi:NFU1(display_short)|uniprotkb:CGI-33(orf name)|uniprotkb:HIRIP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001002755.1|refseq:NP_056515.2|refseq:NP_001002756.1|ensembl:ENSG00000169599(gene)|ensembl:ENST00000410022(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001075(NIF system FeS cluster assembly, NifU, C-terminal)|interpro:IPR014824(NIF system FeS cluster assembly, NifU-like scaffold, N-terminal)|interpro:IPR034904|interpro:IPR036498|rcsb pdb:2LTM|rcsb pdb:2M5O|refseq:XP_016859297.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ilyUYSw8tpfn8DDWGsj96O6f7jk9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P62714 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P60228 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UGP4 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174791|imex:IM-17346-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 intact-crc:DB55289E25FB7FB3|rigid:fdaAopEP+vYkaQBteByRnx8erp8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q92805 intact:EBI-6248094 intact:EBI-6164177|ensembl:ENSP00000362656|uniprotkb:Q5T164|uniprotkb:Q8IYZ9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:goga1_human(display_long)|uniprotkb:GOLGA1(gene name)|psi-mi:GOLGA1(display_short)|uniprotkb:Golgin-97(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000136935(gene)|ensembl:ENST00000373555(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|refseq:NP_002068.1|refseq:XP_006717125.1|refseq:XP_006717126.1|refseq:XP_005251986.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:5SRVVvNxZ7PikOK9zV4HypxK8i49606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9BU89 intact:EBI-6248094 intact:EBI-6164171|ensembl:ENSP00000398882|ensembl:ENSP00000500806|uniprotkb:O75265 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dohh_human(display_long)|uniprotkb:DOHH(gene name)|psi-mi:DOHH(display_short)|uniprotkb:Deoxyhypusine dioxygenase(gene name synonym)|uniprotkb:Deoxyhypusine monooxygenase(gene name synonym)|uniprotkb:HEAT-like repeat-containing protein 1(gene name synonym)|uniprotkb:HLRC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000129932(gene)|ensembl:ENST00000427575(transcript)|ensembl:ENST00000672935(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0008612"(peptidyl-lysine modification to peptidyl-hypusine)|go:"GO:0019135"(deoxyhypusine monooxygenase activity)|interpro:IPR004155(PBS lyase HEAT-like repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR027517|rcsb pdb:4D4Z|rcsb pdb:4D50|reactome:R-HSA-204626|go:"GO:0016491"(oxidoreductase activity)|refseq:NP_001138637.1|refseq:NP_112594.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:l0UcUgujKCQ4M7OAYNTaXxIl2M49606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O14976 intact:EBI-6248094 intact:EBI-714707|uniprotkb:Q9BVY6|uniprotkb:Q5U4P5|intact:EBI-28970318|ensembl:ENSP00000314499 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:gak_human(display_long)|uniprotkb:GAK(gene name)|psi-mi:GAK(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000314499|ensembl:ENST00000511163|ensembl:ENSP00000421361|refseq:NP_005246.2|refseq:NP_001305063.1|ensembl:ENSG00000178950(gene)|ensembl:ENST00000314167(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014020(C2 tensin-type)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|interpro:IPR036869|rcsb pdb:4C57|rcsb pdb:4C58|rcsb pdb:4C59|rcsb pdb:4O38|rcsb pdb:4Y8D|rcsb pdb:5Y7Z|rcsb pdb:5Y80|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0072318"(clathrin coat disassembly) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+CTVzAL9y1B3+JIg6PHsj8QXIjE9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q07820 intact:EBI-6248094 intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TB72 intact:EBI-6248094 intact:EBI-311190|uniprotkb:O00234|uniprotkb:Q53TV7|uniprotkb:Q8WY43|uniprotkb:Q9HAN2|uniprotkb:B4E2B6|uniprotkb:B3KSL0|uniprotkb:D6W527 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:pum2_human(display_long)|uniprotkb:PUM2(gene name)|psi-mi:PUM2(display_short)|uniprotkb:KIAA0235(gene name synonym)|uniprotkb:PUMH2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056132.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR001313(Pumilio RNA-binding region)|rcsb pdb:3Q0Q|rcsb pdb:3Q0R|rcsb pdb:3Q0S|refseq:NP_001269681.1|interpro:IPR033133|refseq:XP_011531021.1|refseq:XP_011531022.1|refseq:XP_011531023.1|refseq:XP_005262664.1|refseq:XP_005262666.1|refseq:XP_006712036.1|refseq:XP_006712037.1|interpro:IPR033712|refseq:XP_016859190.1|refseq:XP_016859191.1|refseq:XP_016859196.1|refseq:XP_016859197.1|reactome:R-HSA-8951664|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0051983"(regulation of chromosome segregation) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:WOut5XivMQAQkHVKu1wjFTK6ePM9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UBQ5 intact:EBI-6248094 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q07864 intact:EBI-6248094 intact:EBI-348526|uniprotkb:Q13533|intact:EBI-28987244|ensembl:ENSP00000322570|uniprotkb:Q86VH9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe1_human(display_long)|uniprotkb:POLE(gene name)|psi-mi:POLE(display_short)|uniprotkb:POLE1(gene name synonym)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006222.2|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0048568"(embryonic organ development)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:5VBN|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962|go:"GO:0008270"(zinc ion binding)|ensembl:ENSG00000177084(gene)|ensembl:ENST00000320574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|ensembl:ENSP00000322570|dip:DIP-24243N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:oPDFCAO2AeDB4UjbeBvo8DPi+ow9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H1A4 intact:EBI-6248094 intact:EBI-395918|uniprotkb:Q2M3H8|uniprotkb:Q9BSE6|uniprotkb:Q9H8D0|ensembl:ENSP00000339109 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:apc1_human(display_long)|uniprotkb:ANAPC1(gene name)|psi-mi:ANAPC1(display_short)|uniprotkb:TSG24(gene name synonym)|uniprotkb:Cyclosome subunit 1(gene name synonym)|uniprotkb:Testis-specific gene 24 protein(gene name synonym)|uniprotkb:Mitotic checkpoint regulator(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_073153.1|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENSG00000153107(gene)|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|ensembl:ENST00000341068(transcript)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5L9U|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:5LCW|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|rcsb pdb:5LGG|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024990|interpro:IPR041221|mint:Q9H1A4|dip:DIP-32940N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:GCcoaN+24WplwiaqcHwHsjyWn789606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P55884 intact:EBI-6248094 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P60228 intact:EBI-6248094 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P61758 intact:EBI-6248094 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8N163 intact:EBI-6248094 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8NFF5 intact:EBI-6248094 intact:EBI-742815|uniprotkb:Q8N5J1|uniprotkb:Q8N686|uniprotkb:Q8WU93|uniprotkb:Q8WUJ4|uniprotkb:Q96CR8|uniprotkb:Q99764|uniprotkb:Q9HBN6|ensembl:ENSP00000292180 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:fad1_human(display_long)|uniprotkb:FMN adenylyltransferase(gene name synonym)|uniprotkb:FAD pyrophosphorylase(gene name synonym)|uniprotkb:Flavin adenine dinucleotide synthase(gene name synonym)|uniprotkb:FLAD1(gene name)|psi-mi:FLAD1(display_short)|uniprotkb:PP591(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001171820.1|refseq:NP_001171821.1|refseq:NP_079483.3|refseq:NP_958800.1|ensembl:ENSG00000160688(gene)|ensembl:ENST00000292180(transcript)|go:"GO:0003919"(FMN adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006747"(FAD biosynthetic process)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR002500(Phosphoadenosine phosphosulphate reductase)|interpro:IPR012183(FAD synthetase, molybdopterin binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036425|mint:Q8NFF5|reactome:R-HSA-196843 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:XIktrF0PkC+W6/1cHF4l/WWtGUs9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P43246 intact:EBI-6248094 intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O15371 intact:EBI-6248094 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q14152 intact:EBI-6248094 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O60232 intact:EBI-6248094 intact:EBI-741415|ensembl:ENSP00000312318 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:znrd2_human(display_long)|uniprotkb:ZNRD2(gene name)|psi-mi:ZNRD2(display_short)|uniprotkb:Autoantigen p27(gene name synonym)|uniprotkb:SSSCA1(gene name synonym)|uniprotkb:Sjoegren syndrome/scleroderma autoantigen 1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006387.1|ensembl:ENSG00000173465(gene)|ensembl:ENST00000309328(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0051301"(cell division)|interpro:IPR009563(Sjogrens syndrome scleroderma autoantigen 1)|rcsb pdb:6HCZ psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Uou80pZneoL39/0YYzb1TAbiB2I9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q32P44 intact:EBI-6248094 intact:EBI-1046713|uniprotkb:Q6ZQW7|uniprotkb:Q8NA55|ensembl:ENSP00000378254|intact:EBI-2556256 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:emal3_human(display_long)|uniprotkb:EML3(gene name)|psi-mi:EML3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 intact:EBI-1058671(primary-reference)|go:"GO:0015630"(microtubule cytoskeleton)|ensembl:ENSG00000149499(gene)|ensembl:ENST00000394773(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_694997.2|refseq:NP_001287722.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Q5NalpeOEiROb0QG6vDt/b0Sna49606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P58107 intact:EBI-6248094 intact:EBI-297954|uniprotkb:Q76E58|ensembl:ENSP00000484472|uniprotkb:A0A087X1U6|uniprotkb:Q9NSU9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:epipl_human(display_long)|uniprotkb:EPPK1(gene name)|psi-mi:EPPK1(display_short)|uniprotkb:EPIPL(gene name synonym)|uniprotkb:450 kDa epidermal antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000484472|ensembl:ENSG00000261150(gene)|ensembl:ENST00000615648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042995"(cell projection)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0071944"(cell periphery)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1905041"(regulation of epithelium regeneration)|go:"GO:1990254"(keratin filament binding)|interpro:IPR001101(Plectin repeat)|interpro:IPR035915|interpro:IPR043197|refseq:NP_112598.3|refseq:XP_016869379.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:5ThrRQj4JeRG4xjZxMgueWUrjuA9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99613 intact:EBI-6248094 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TCU4 intact:EBI-6248094 intact:EBI-308651|uniprotkb:Q53S05|uniprotkb:Q580Q8|uniprotkb:Q86VP9|uniprotkb:Q9Y4G4|ensembl:ENSP00000482968|uniprotkb:A0A087WZY3 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:alms1_human(display_long)|uniprotkb:ALMS1(gene name)|psi-mi:ALMS1(display_short)|uniprotkb:KIAA0328(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000116127(gene)|ensembl:ENST00000613296(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0008017"(microtubule binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR028781|interpro:IPR029299|interpro:IPR040972|mint:Q8TCU4|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_055935.4 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:e91Hcs947kpQHPVhWAJRtYegdPg9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UKK3 intact:EBI-6248094 intact:EBI-2623021|uniprotkb:Q5QNZ9|uniprotkb:O75903|uniprotkb:Q14682|uniprotkb:Q9H1M6|ensembl:ENSP00000371419 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:parp4_human(display_long)|uniprotkb:ADPRTL1(gene name synonym)|uniprotkb:KIAA0177(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:193 kDa vault protein(gene name synonym)|uniprotkb:PARP-related/IalphaI-related H5/proline-rich(gene name synonym)|uniprotkb:"Vault poly(ADP-ribose) polymerase"(gene name synonym)|uniprotkb:PARP4(gene name)|psi-mi:PARP4(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 4(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:XP_011533234.1|refseq:NP_006428.2|ensembl:ENSG00000102699(gene)|ensembl:ENST00000381989(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006281"(DNA repair)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0042493"|go:"GO:0051972"(regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001357(BRCT)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR031273|interpro:IPR036420|interpro:IPR036465|interpro:IPR036616|mint:Q9UKK3|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:d1n+oei4ZSmqUnvJzMe6RLq2XOc9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O00303 intact:EBI-6248094 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q12948 intact:EBI-6248094 intact:EBI-1175253|uniprotkb:Q86UP7|uniprotkb:Q9BYM1|uniprotkb:Q9NUE5|uniprotkb:Q9UDD0|uniprotkb:Q9UP06|ensembl:ENSP00000493906 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:foxc1_human(display_long)|uniprotkb:Forkhead-related protein FKHL7(gene name synonym)|uniprotkb:Forkhead-related transcription factor 3(gene name synonym)|uniprotkb:FOXC1(gene name)|psi-mi:FOXC1(display_short)|uniprotkb:FKHL7(gene name synonym)|uniprotkb:FREAC3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENST00000645831(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001654"(eye development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|ensembl:ENSG00000054598(gene)|go:"GO:0001822"(kidney development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021549"(cerebellum development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0008301"(DNA binding, bending)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0060038"(cardiac muscle cell proliferation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR033067|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR036388|interpro:IPR036390|mint:Q12948|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072010"(glomerular epithelium development)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902038"(positive regulation of hematopoietic stem cell differentiation)|go:"GO:1902257"(negative regulation of apoptotic process involved in outflow tract morphogenesis)|go:"GO:1904798"(positive regulation of core promoter binding)|ensembl:ENSP00000493906|refseq:NP_001444.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+HuKwX8xMx86iCQW/a+vy/rWP389606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UGP4 intact:EBI-6248094 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UMS0 intact:EBI-6248094 intact:EBI-725252|uniprotkb:Q53QE5|uniprotkb:Q6VNZ8|uniprotkb:Q7Z5B1|uniprotkb:Q7Z5B2|uniprotkb:Q9Y322|uniprotkb:B4DUL9|ensembl:ENSP00000387219 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:nfu1_human(display_long)|uniprotkb:HIRA-interacting protein 5(gene name synonym)|uniprotkb:NFU1(gene name)|psi-mi:NFU1(display_short)|uniprotkb:CGI-33(orf name)|uniprotkb:HIRIP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001002755.1|refseq:NP_056515.2|refseq:NP_001002756.1|ensembl:ENSG00000169599(gene)|ensembl:ENST00000410022(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001075(NIF system FeS cluster assembly, NifU, C-terminal)|interpro:IPR014824(NIF system FeS cluster assembly, NifU-like scaffold, N-terminal)|interpro:IPR034904|interpro:IPR036498|rcsb pdb:2LTM|rcsb pdb:2M5O|refseq:XP_016859297.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ilyUYSw8tpfn8DDWGsj96O6f7jk9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P23526 intact:EBI-6248094 intact:EBI-1053240|uniprotkb:Q96A36|ensembl:ENSP00000217426|uniprotkb:B3KUN3|uniprotkb:F5H737|uniprotkb:A8K307|uniprotkb:E1P5P2 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:sahh_human(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:AHCY(gene name)|psi-mi:AHCY(display_short)|uniprotkb:SAHH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_000678.1|refseq:NP_001155238.1|ensembl:ENSG00000101444(gene)|ensembl:ENST00000217426(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P23526|rcsb pdb:1A7A|rcsb pdb:1LI4|refseq:XP_011526961.1|refseq:XP_005260374.1|refseq:NP_001309013.1|refseq:NP_001309014.1|rcsb pdb:3NJ4|rcsb pdb:4PFJ|rcsb pdb:4PGF|rcsb pdb:4YVF|rcsb pdb:5W49|rcsb pdb:5W4B|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-2408508|reactome:R-HSA-5578997|refseq:XP_016883197.1|refseq:XP_016883198.1|dip:DIP-50557N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+y7rwgw9EIMaVrkt4/9kbZM44sg9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9BZF3 intact:EBI-6248094 intact:EBI-2372709|uniprotkb:B4DTW1|uniprotkb:Q4ZG68|uniprotkb:Q53T68|uniprotkb:Q59H61|uniprotkb:Q7Z4Q1|uniprotkb:Q8N9T0|uniprotkb:Q96SR1|uniprotkb:C4AME4|uniprotkb:C4AMC0|uniprotkb:D3DPF6|uniprotkb:D3DPF7|uniprotkb:Q86V84|intact:EBI-28980578|ensembl:ENSP00000190611 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl6_human(display_long)|uniprotkb:OSBPL6(gene name)|psi-mi:OSBPL6(display_short)|uniprotkb:ORP6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001188409.1|refseq:NP_001188410.1|refseq:NP_001188411.1|refseq:NP_115912.1|refseq:NP_665682.1|ensembl:ENSP00000190611|ensembl:ENST00000315022|ensembl:ENSP00000318723|ensembl:ENST00000357080|ensembl:ENSP00000349591|ensembl:ENST00000359685|ensembl:ENSP00000352713|ensembl:ENST00000392505|ensembl:ENSP00000376293|ensembl:ENST00000409045|ensembl:ENSP00000387248|ensembl:ENST00000409631|ensembl:ENSP00000386885|refseq:XP_016858755.1|refseq:XP_016858756.1|refseq:XP_016858759.1|refseq:XP_016858760.1|ensembl:ENSG00000079156(gene)|ensembl:ENST00000190611(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9BZF3|reactome:R-HSA-192105 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:fOUP23b3kO1lBSBPNHP6Ghe6i8c9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9Y262 intact:EBI-6248094 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NR33 intact:EBI-6248094 intact:EBI-867034|uniprotkb:Q53TR2|ensembl:ENSP00000420176 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe4_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p12(gene name synonym)|uniprotkb:POLE4(gene name)|psi-mi:POLE4(display_short)|uniprotkb:DNA polymerase II subunit 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_063949.2|ensembl:ENSG00000115350(gene)|ensembl:ENST00000483063(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ZtsQxDhQebNPEqYTb+G8yXvXp/49606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P49591 intact:EBI-6248094 intact:EBI-1053431|uniprotkb:Q5T5C8|uniprotkb:Q9NSE3|uniprotkb:B2R6Y9|ensembl:ENSP00000234677 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:sysc_human(display_long)|uniprotkb:SARS1(gene name)|psi-mi:SARS1(display_short)|uniprotkb:SARS(gene name synonym)|uniprotkb:SERS(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006504.2|ensembl:ENSG00000031698(gene)|ensembl:ENST00000234677(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:1904046"(negative regulation of vascular endothelial growth factor production)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR015866(Seryl-tRNA synthetase, class IIa, N-terminal)|interpro:IPR033729|interpro:IPR042103|rcsb pdb:3VBB|rcsb pdb:4L87|rcsb pdb:4RQE|rcsb pdb:4RQF|reactome:R-HSA-2408557|reactome:R-HSA-379716|dip:DIP-38215N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:4+Ai/MIybmiKJyfa0C0bhnW/CG49606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UHF7 intact:EBI-6248094 intact:EBI-2556151|uniprotkb:Q9UHH6|uniprotkb:Q9NWE1|uniprotkb:Q08AU2|uniprotkb:B4E1Z5|ensembl:ENSP00000220888|ensembl:ENSP00000492037 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:trps1_human(display_long)|uniprotkb:Tricho-rhino-phalangeal syndrome type I protein(gene name synonym)|uniprotkb:Zinc finger protein GC79(gene name synonym)|uniprotkb:TRPS1(gene name)|psi-mi:TRPS1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_054831.2|refseq:NP_001269831.1|refseq:XP_011515566.1|refseq:XP_011515568.1|refseq:XP_011515570.1|refseq:NP_001269832.1|refseq:XP_006716688.1|refseq:NP_001317528.1|ensembl:ENSG00000104447(gene)|ensembl:ENST00000220888(transcript)|ensembl:ENST00000640765(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR028440|interpro:IPR036236 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:M9Qu8GLaQiBGt4rWs+NuYJas8fs9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NRF9 intact:EBI-6248094 intact:EBI-744901|uniprotkb:Q5W0U1|uniprotkb:Q8N758|uniprotkb:Q8NCE5|uniprotkb:Q9NR32|ensembl:ENSP00000363284|ensembl:ENSP00000363286 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe3_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p17(gene name synonym)|uniprotkb:Chromatin accessibility complex 17 kDa protein(gene name synonym)|uniprotkb:Arsenic-transactivated protein(gene name synonym)|uniprotkb:POLE3(gene name)|psi-mi:POLE3(display_short)|uniprotkb:CHRAC17(gene name synonym)|uniprotkb:DNA polymerase II subunit 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001265184.1|refseq:NP_059139.3|ensembl:ENSG00000148229(gene)|ensembl:ENST00000374169(transcript)|ensembl:ENST00000374171(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:eTI1XsrypxKqml09tm4GAImoZgI9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NZN5 intact:EBI-6248094 intact:EBI-821440|uniprotkb:O15086|uniprotkb:Q6P526|ensembl:ENSP00000380942 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:arhgc_human(display_long)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)|uniprotkb:ARHGEF12(gene name)|psi-mi:ARHGEF12(display_short)|uniprotkb:KIAA0382(gene name synonym)|uniprotkb:LARG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001185594.1|refseq:NP_056128.1|refseq:NP_001288013.1|refseq:XP_011541022.1|refseq:XP_016872910.1|ensembl:ENST00000356641|ensembl:ENSP00000349056|ensembl:ENSP00000380942|dip:DIP-37887N|ensembl:ENSG00000196914(gene)|ensembl:ENST00000397843(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|rcsb pdb:1TXD|rcsb pdb:1X86|rcsb pdb:2OMJ|rcsb pdb:2OS6|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:lAnj6rTvOnWPt6fcTzMm8G1klKY9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O95714 intact:EBI-6248094 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H4L5 intact:EBI-6248094 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174875|imex:IM-17346-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:AB0BC1CB68BBEB72|rigid:RUrScN3uQim2piA3BfGzaaG4DWw false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q86XZ4 intact:EBI-6164309 intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9HD23 intact:EBI-6164309 intact:EBI-6164303|ensembl:ENSP00000367637|uniprotkb:B4DQL2|uniprotkb:A8K4U3|uniprotkb:B3KNN2|uniprotkb:Q5T3Y1|uniprotkb:Q6NTG4|uniprotkb:Q96KF8|uniprotkb:Q9BVP1 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:mrs2_human(display_long)|uniprotkb:MRS2(gene name)|psi-mi:MRS2(display_short)|uniprotkb:HPT(gene name synonym)|uniprotkb:MRS2-like protein(gene name synonym)|uniprotkb:MRS2L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000124532(gene)|ensembl:ENST00000378386(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045016"(mitochondrial magnesium ion transmembrane transport)|go:"GO:0055085"(transmembrane transport)|interpro:IPR039204|reactome:R-HSA-5223345|refseq:NP_001273193.1|refseq:NP_001273194.1|refseq:NP_001273195.1|refseq:NP_065713.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:qvKwgSW3lcwro4mQsW0ex2yN6IM9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q7Z7H5 intact:EBI-6164309 intact:EBI-2561449|uniprotkb:Q8N2P6|uniprotkb:A4D2K8|uniprotkb:Q7Z432|uniprotkb:B4DFJ4|uniprotkb:Q56VW3|ensembl:ENSP00000404042 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmed4_human(display_long)|uniprotkb:TMED4(gene name)|psi-mi:TMED4(display_short)|uniprotkb:ERS25(gene name synonym)|uniprotkb:Endoplasmic reticulum stress-response protein 25(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 156(gene name synonym)|uniprotkb:GMP25iso(gene name synonym)|uniprotkb:p24 family protein alpha-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_872353.2|refseq:NP_001289987.1|refseq:NP_001289989.1|ensembl:ENSG00000158604(gene)|ensembl:ENST00000457408(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:SQNdxIm/WnTmBCD0BS0YjAny6R89606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9Y6G3 intact:EBI-6164309 intact:EBI-713615|uniprotkb:Q96Q48|ensembl:ENSP00000447547|ensembl:ENSP00000449392|ensembl:ENSP00000449884|uniprotkb:Q9P0S1|uniprotkb:Q6FID1 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:rm42_human(display_long)|uniprotkb:MRPL31(gene name synonym)|uniprotkb:MRPL42(gene name)|psi-mi:MRPL42(display_short)|uniprotkb:MRPS32(gene name synonym)|uniprotkb:RPML31(gene name synonym)|uniprotkb:39S ribosomal protein L31, mitochondrial(gene name synonym)|uniprotkb:HSPC204(orf name)|uniprotkb:PTD007(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL42(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_054769.1|refseq:NP_751917.1|ensembl:ENSG00000198015(gene)|ensembl:ENST00000549561(transcript)|ensembl:ENST00000549982(transcript)|ensembl:ENST00000552217(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|interpro:IPR019346|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:Y831BAUiZ3vI12KTXxRvGavXfmg9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q5T3I0 intact:EBI-6164309 intact:EBI-2372076|uniprotkb:Q5T3I1|uniprotkb:Q6ZUE7|uniprotkb:Q8IWG8|uniprotkb:Q9NXH4 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:gptc4_human(display_long)|uniprotkb:GPATCH4(gene name)|psi-mi:GPATCH4(display_short)|uniprotkb:GPATC4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 interpro:IPR000467(D111/G-patch)|mint:Q5T3I0|go:"GO:0003723"(RNA binding) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:R2hFHYGQh2jmLbLg+BNATVimtNA9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q96BP2 intact:EBI-6164309 intact:EBI-5454898|ensembl:ENSP00000361923 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:chch1_human(display_long)|uniprotkb:CHCHD1(gene name)|psi-mi:CHCHD1(display_short)|uniprotkb:C10orf34(gene name synonym)|uniprotkb:Nuclear protein C2360(gene name synonym)|uniprotkb:28S ribosomal protein S37, mitochondrial(gene name synonym)|uniprotkb:MRPS37(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS37(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_976043.1|ensembl:ENSG00000172586(gene)|ensembl:ENST00000372833(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR009069(MTCP1)|interpro:IPR010625(CHCH)|interpro:IPR033620|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:NrXh0XQ/wnElrxTM/KjipjA6WYY9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q13123 intact:EBI-6164309 intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q2TAY7 intact:EBI-6164309 intact:EBI-298027|uniprotkb:Q9BU59|uniprotkb:Q9HA96|uniprotkb:Q9NVD1|ensembl:ENSP00000380336|uniprotkb:B4E3L0 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:smu1_human(display_long)|uniprotkb:Smu-1 suppressor of mec-8 and unc-52 protein homolog(gene name synonym)|uniprotkb:SMU1(gene name)|psi-mi:SMU1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENST00000397149(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q2TAY7|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:6Q8F|rcsb pdb:6Q8I|rcsb pdb:6Q8J|ensembl:ENSG00000122692(gene)|refseq:NP_060695.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:zbTRfKynNIUSFY8IEqyYWh3JSho9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q04837 intact:EBI-6164309 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:P49755 intact:EBI-6164309 intact:EBI-998422|uniprotkb:Q15602|uniprotkb:Q16536|uniprotkb:Q86TC2|uniprotkb:Q86TS5|uniprotkb:B2R605|intact:EBI-1058680|ensembl:ENSP00000303145 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmeda_human(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmp-21-I(gene name synonym)|uniprotkb:p24delta(gene name synonym)|uniprotkb:S31III125(gene name synonym)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)|uniprotkb:S31I125(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:P49755|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811434|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|ensembl:ENSG00000170348(gene)|ensembl:ENST00000303575(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|refseq:NP_006818.3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:Sj4B0x1qf0VJmI1aDFaw2/PiTxM9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:P29372 intact:EBI-6164309 intact:EBI-1043398|uniprotkb:Q13770|uniprotkb:Q15275|uniprotkb:Q15961|uniprotkb:Q96BZ6|uniprotkb:Q96S33|uniprotkb:Q9NNX5|ensembl:ENSP00000219431|intact:EBI-10970139|uniprotkb:G5E9E2|uniprotkb:Q5J9I4 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:3mg_human(display_long)|uniprotkb:3-methyladenine DNA glycosidase(gene name synonym)|uniprotkb:ADPG(gene name synonym)|uniprotkb:3-alkyladenine DNA glycosylase(gene name synonym)|uniprotkb:N-methylpurine-DNA glycosylase(gene name synonym)|uniprotkb:MPG(gene name)|psi-mi:MPG(display_short)|uniprotkb:AAG(gene name synonym)|uniprotkb:ANPG(gene name synonym)|uniprotkb:MID1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000103152(gene)|ensembl:ENST00000219431(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003905"(alkylbase DNA N-glycosylase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008725"(DNA-3-methyladenine glycosylase activity)|go:"GO:0019104"(DNA N-glycosylase activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043916"(DNA-7-methylguanine glycosylase activity)|go:"GO:0045007"(depurination)|go:"GO:0052821"(DNA-7-methyladenine glycosylase activity)|go:"GO:0052822"(DNA-3-methylguanine glycosylase activity)|interpro:IPR003180("Methylpurine-DNA glycosylase (MPG)")|interpro:IPR011034(Formyl transferase, C-terminal-like)|interpro:IPR036995|mint:P29372|rcsb pdb:1BNK|rcsb pdb:1EWN|rcsb pdb:1F4R|rcsb pdb:1F6O|rcsb pdb:3QI5|rcsb pdb:3UBY|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-110357|refseq:NP_001015052.1|refseq:NP_002425.2|refseq:NP_001015054.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:DIssmhwGHsxiJoewCmV2zDEmSuI9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q15363 intact:EBI-6164309 intact:EBI-998485|ensembl:ENSP00000262225 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.74 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9BVK6 intact:EBI-6164309 intact:EBI-1056827|uniprotkb:Q8WZ61|uniprotkb:Q14437|ensembl:ENSP00000330945 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmed9_human(display_long)|uniprotkb:TMED9(gene name)|psi-mi:TMED9(display_short)|uniprotkb:GP25L2(gene name synonym)|uniprotkb:Glycoprotein 25L2(gene name synonym)|uniprotkb:p25(gene name synonym)|uniprotkb:p24 family protein alpha-2(gene name synonym)|uniprotkb:GMP25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6174998|imex:IM-17346-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_059980.2|ensembl:ENSG00000184840(gene)|ensembl:ENST00000332598(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:Q9BVK6|reactome:R-HSA-6807878|reactome:R-HSA-6811434 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:z5YDyY6mtnc4WGWU9G9sNgp+Ga09606 intact-crc:32F61B03EFDA59EE|rigid:cO/edy6+PTzP5vtzWz4to3wDDGA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12497-PRO_0000042399 uniprotkb:P62993 intact:EBI-6179753 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:p12497-pro_0000042399(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175051|imex:IM-17346-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1026248(chain-parent) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:588|chain-seq-end:1147|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Klpids91/HYZGIB9q9E28gVETBU11698 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:9DC83D0433AD6EE2|rigid:5Pekgj/6WZGQS/y894I2L/J4+lo false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12497-PRO_0000042399 uniprotkb:Q69YN4 intact:EBI-6179753 intact:EBI-2819293|uniprotkb:Q9BTH4|uniprotkb:Q8IXH4|uniprotkb:Q6AHX9|uniprotkb:Q6NT78|uniprotkb:Q9UFW1|uniprotkb:Q9NWR3|uniprotkb:Q9P2B8|uniprotkb:Q9H9C9|uniprotkb:Q2M1N0|uniprotkb:Q7Z6C7|ensembl:ENSP00000297591 psi-mi:p12497-pro_0000042399(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:vir_human(display_long)|uniprotkb:VIRMA(gene name)|psi-mi:VIRMA(display_short)|uniprotkb:KIAA1429(gene name synonym)|uniprotkb:MSTP054(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175051|imex:IM-17346-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1026248(chain-parent) refseq:NP_056311.2|refseq:NP_892121.1|ensembl:ENSG00000164944(gene)|ensembl:ENST00000297591(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0080009"(mRNA methylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026736|interpro:IPR031801|mint:Q69YN4 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:588|chain-seq-end:1147|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Klpids91/HYZGIB9q9E28gVETBU11698 rogid:JXKhohRVBiT4P++8+/edtkir+h89606 intact-crc:9DC83D0433AD6EE2|rigid:5Pekgj/6WZGQS/y894I2L/J4+lo false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q8NAF0 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-6164383|intact:EBI-28978763|ensembl:ENSP00000320188 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:zn579_human(display_long)|uniprotkb:ZNF579(gene name)|psi-mi:ZNF579(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSG00000218891(gene)|ensembl:ENST00000325421(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSP00000320188|refseq:NP_689813.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uJ613Jxktit2lNClmAFV78Cz1XM9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P35556 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-6164392|ensembl:ENSP00000424571|ensembl:ENSP00000262464|uniprotkb:B4DU01|uniprotkb:Q59ES6 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:fbn2_human(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35556|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|interpro:IPR018097|ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|refseq:NP_001990.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P51784 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UK99 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2509901|uniprotkb:B3KY16|uniprotkb:D3DR05|uniprotkb:Q9H0V2|uniprotkb:Q86X90|uniprotkb:Q9NUX2|ensembl:ENSP00000265651 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:fbx3_human(display_long)|uniprotkb:FBXO3(gene name)|psi-mi:FBXO3(display_short)|uniprotkb:FBX3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_036307.2|refseq:NP_208385.1|dip:DIP-53688N|ensembl:ENSG00000110429(gene)|ensembl:ENST00000265651(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007474(ApaG)|interpro:IPR018958|interpro:IPR028388|interpro:IPR036047|interpro:IPR036767|interpro:IPR037883|rcsb pdb:5HDW psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:zQB8ig3s51tXN81NtMrou84Rv6I9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q03111 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O60563 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O15355 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q96JP5 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1052613|uniprotkb:Q86V47|uniprotkb:Q96JP4|uniprotkb:Q96QA3|uniprotkb:A6NHC4|uniprotkb:A8MSG7|ensembl:ENSP00000339030 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:zfp91_human(display_long)|uniprotkb:ZFP91(gene name)|psi-mi:ZFP91(display_short)|uniprotkb:FKSG11(orf name)|uniprotkb:ZNF757(gene name synonym)|uniprotkb:Zinc finger protein 757(gene name synonym)|uniprotkb:Zinc finger protein 91 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZFP91(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001183980.1|refseq:NP_444251.1|ensembl:ENSG00000186660(gene)|ensembl:ENST00000316059(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q96JP5|rcsb pdb:2M9A|go:"GO:0004842"(ubiquitin-protein transferase activity) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:oQuzxnamj/z05P/rG8EXnXTjzz89606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q96HN2 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1056923|uniprotkb:O94917|uniprotkb:B4DIZ5|uniprotkb:D9N155|ensembl:ENSP00000315931 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sahh3_human(display_long)|uniprotkb:AHCYL2(gene name)|psi-mi:AHCYL2(display_short)|uniprotkb:KIAA0828(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 3(gene name synonym)|uniprotkb:S-adenosylhomocysteine hydrolase-like protein 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3) 2"(gene name synonym)|uniprotkb:Long-IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001124192.1|refseq:NP_001124194.2|refseq:NP_001124195.1|refseq:NP_056143.1|ensembl:ENSG00000158467(gene)|ensembl:ENST00000325006(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0043005"(neuron projection)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|rcsb pdb:3GVP|reactome:R-HSA-425381 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:OOrDmlSeGOWqnAhYQcNa4tF5pk09606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9C0C9 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2339946|uniprotkb:Q8N425|uniprotkb:Q9H9B2|uniprotkb:Q6PIZ2|uniprotkb:Q9H7E4|uniprotkb:Q8TBN1|uniprotkb:A6NDU5|uniprotkb:Q9BSW1|uniprotkb:Q69YP4|uniprotkb:Q86UA4|uniprotkb:Q9H6E6|ensembl:ENSP00000323687 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ube2o_human(display_long)|uniprotkb:UBE2O(gene name)|psi-mi:UBE2O(display_short)|uniprotkb:KIAA1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_071349.3|ensembl:ENSG00000175931(gene)|ensembl:ENST00000319380(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9C0C9|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:FftBetvip/qFQAsQxmxRnGy8ctA9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q96EB6 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9NXF7 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2559096|ensembl:ENSP00000371682|uniprotkb:B3KPB7 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:dca16_human(display_long)|uniprotkb:DCAF16(gene name)|psi-mi:DCAF16(display_short)|uniprotkb:C4orf30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_060211.3|ensembl:ENSG00000163257(gene)|ensembl:ENST00000382247(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR028216|mint:Q9NXF7|reactome:R-HSA-8951664|refseq:NP_001332809.1|refseq:NP_001332810.1|refseq:NP_001332811.1|refseq:NP_001332813.1|refseq:NP_001332814.1|refseq:XP_016863816.1|refseq:XP_016863817.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:nw3uabUDsivZMGy04ZZolwJmdeI9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UHB7 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P50750 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UQ35 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1050142|uniprotkb:A6NKB9|uniprotkb:Q9UHA8|uniprotkb:Q9UQ36|uniprotkb:Q9UQ37|uniprotkb:Q9UQ38|uniprotkb:Q9UQ40|uniprotkb:O15038|uniprotkb:O94803|uniprotkb:Q6NSL3|uniprotkb:Q6PIM3|uniprotkb:Q6PK40|uniprotkb:Q8IW17|uniprotkb:Q96GY7|uniprotkb:Q9P0G1|uniprotkb:D3DU97|ensembl:ENSP00000301740 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:srrm2_human(display_long)|uniprotkb:Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa(gene name synonym)|uniprotkb:Splicing coactivator subunit SRm300(gene name synonym)|uniprotkb:300 kDa nuclear matrix antigen(gene name synonym)|uniprotkb:SRRM2(gene name)|psi-mi:SRRM2(display_short)|uniprotkb:KIAA0324(gene name synonym)|uniprotkb:SRL300(gene name synonym)|uniprotkb:SRM300(gene name synonym)|uniprotkb:HSPC075(orf name)|uniprotkb:Tax-responsive enhancer element-binding protein 803(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_057417.3|ensembl:ENSG00000167978(gene)|ensembl:ENST00000301740(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q9UQ35|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7DVQ|reactome:R-HSA-72163 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:3yyPAOaCzKSCEg5guJSbq0MWrHI9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O43865 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P31942 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-711437|uniprotkb:Q9NPI4|uniprotkb:Q9UFU4|uniprotkb:Q9Y4J5|uniprotkb:Q9BSX1|uniprotkb:Q9NP53|uniprotkb:Q9NP96|uniprotkb:Q9NPA7|ensembl:ENSP00000265866|uniprotkb:A8K682|uniprotkb:B3KRE1 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:hnrh3_human(display_long)|uniprotkb:HNRNPH3(gene name)|psi-mi:HNRNPH3(display_short)|uniprotkb:HNRPH3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein 2H9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSG00000096746(gene)|ensembl:ENST00000265866(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034969|interpro:IPR034970|interpro:IPR035979|mint:P31942|refseq:NP_036339.1|refseq:NP_067676.2|refseq:NP_001309363.1|refseq:NP_001309365.1|refseq:NP_001309366.1|refseq:NP_001309367.1|refseq:NP_001309368.1|refseq:NP_001309369.1|refseq:NP_001309370.1|refseq:NP_001309374.1|refseq:NP_001309375.1|refseq:NP_001309376.1|refseq:NP_001309377.1|refseq:NP_001309378.1|refseq:XP_016871657.1|refseq:XP_016871658.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:iJGBIhPXnQIIFQmgxWB1WjwVXSY9606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q8NCA5 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1210765|uniprotkb:B2RNA2|uniprotkb:Q9Y3Y6|intact:EBI-10970131|ensembl:ENSP00000238823 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:fa98a_human(display_long)|uniprotkb:FAM98A(gene name)|psi-mi:FAM98A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175072|imex:IM-17346-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_056290.3|go:"GO:0032418"(lysosome localization)|go:"GO:0072669"(tRNA-splicing ligase complex)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR018797|mint:Q8NCA5|ensembl:ENSG00000119812(gene)|ensembl:ENST00000238823(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0006479"(protein methylation)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/07/08 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:MEsSX6iNk+0s/sLuUawu0GR9bW89606 intact-crc:7AAEE6443261E601|rigid:y5WR7nIk1V/gV0xQ/NTSIt1LT0E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q7Z6Z7 intact:EBI-779991 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15369 intact:EBI-779991 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13617 intact:EBI-779991 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9UBF6 intact:EBI-779991 intact:EBI-398632|uniprotkb:Q9BXN8|uniprotkb:Q9Y5M7|uniprotkb:A8MTB5|uniprotkb:A8K1H9|uniprotkb:D3DNF7|uniprotkb:D3DNF8|uniprotkb:C9JYL3|ensembl:ENSP00000273480 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:rbx2_human(display_long)|uniprotkb:RNF7(gene name)|psi-mi:RNF7(display_short)|uniprotkb:RBX2(gene name synonym)|uniprotkb:ROC2(gene name synonym)|uniprotkb:SAG(gene name synonym)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Regulator of cullins 2(gene name synonym)|uniprotkb:CKII beta-binding protein 1(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_055060.1|refseq:NP_899060.1|refseq:NP_001188299.1|ensembl:ENSG00000114125(gene)|ensembl:ENST00000273480(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|go:"GO:0051775"(response to redox state)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|rcsb pdb:2ECL|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:FNop0ozErv05khKc5si7nNH/Hww9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:P61289 intact:EBI-779991 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:P11441 intact:EBI-779991 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9UNE7 intact:EBI-779991 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9C0C7 intact:EBI-779991 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q99615 intact:EBI-779991 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13501 intact:EBI-779991 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q8IWV8 intact:EBI-779991 intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15370 intact:EBI-779991 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q7L5D6 intact:EBI-779991 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.74 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9ULX6 intact:EBI-779991 intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:P46379 intact:EBI-779991 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q93034 intact:EBI-779991 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175137|imex:IM-17346-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 intact-crc:7E862FD33EC4C056|rigid:hsO9rvjaKvA438QUhsJEfADZmq4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9NRK6 intact:EBI-6164519 intact:EBI-6164528|ensembl:ENSP00000355637|uniprotkb:Q13040|uniprotkb:Q6P1Q8|uniprotkb:Q9H3V0 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:abcba_human(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ABCB10(gene name)|psi-mi:ABCB10(display_short)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Mitochondrial ATP-binding cassette 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000135776(gene)|ensembl:ENST00000344517(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0006783"(heme biosynthetic process)|interpro:IPR036640|interpro:IPR039421|rcsb pdb:3ZDQ|rcsb pdb:4AYT|rcsb pdb:4AYW|rcsb pdb:4AYX|reactome:R-HSA-1369007|interpro:IPR030260|refseq:NP_036221.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:XJOAh9Mv+ivD/9GzGjjkmvyvf9g9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y6C9 intact:EBI-6164519 intact:EBI-6164522|ensembl:ENSP00000303222|ensembl:ENSP00000495027|uniprotkb:B2R7L8 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:mtch2_human(display_long)|uniprotkb:MTCH2(gene name)|psi-mi:MTCH2(display_short)|uniprotkb:MIMP(gene name synonym)|uniprotkb:Met-induced mitochondrial protein(gene name synonym)|uniprotkb:HSPC032(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 interpro:IPR018108|interpro:IPR023395|mint:Q9Y6C9|go:"GO:0070585"(protein localization to mitochondrion)|ensembl:ENSG00000109919(gene)|ensembl:ENSG00000285121(gene)|ensembl:ENST00000302503(transcript)|ensembl:ENST00000643223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|refseq:NP_001304160.1|refseq:NP_001304161.1|refseq:NP_001304162.1|refseq:NP_055157.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:Lbg7MBRn09cRzoYOiSt4g4FjsjA9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q2PZI1 intact:EBI-6164519 intact:EBI-6164516|ensembl:ENSP00000308695|uniprotkb:O94954|uniprotkb:Q4G151 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:d19l1_human(display_long)|uniprotkb:Protein dpy-19 homolog 1(gene name synonym)|uniprotkb:DPY19L1(gene name)|psi-mi:DPY19L1(display_short)|uniprotkb:Dpy-19-like protein 1(gene name synonym)|uniprotkb:GA0500(gene name synonym)|uniprotkb:KIAA0877(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000173852(gene)|ensembl:ENST00000310974(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018406"(protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan)|interpro:IPR018732|interpro:IPR030041|go:"GO:0000030"(mannosyltransferase activity)|refseq:NP_056098.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:JnDZiz7UFIUQvuIps5neyIQulsY9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O00116 intact:EBI-6164519 intact:EBI-2838732|uniprotkb:A5D8U9|uniprotkb:Q2TU35|ensembl:ENSP00000264167 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:adas_human(display_long)|uniprotkb:AGPS(gene name)|psi-mi:AGPS(display_short)|uniprotkb:Aging-associated gene 5 protein(gene name synonym)|uniprotkb:Alkylglycerone-phosphate synthase(gene name synonym)|uniprotkb:AAG5(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003650.1|ensembl:ENSG00000018510(gene)|ensembl:ENST00000264167(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008609"(alkylglycerone-phosphate synthase activity)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0071949"(FAD binding)|interpro:IPR004113(FAD-linked oxidase, C-terminal)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016164(FAD-linked oxidase-like, C-terminal)|interpro:IPR016167(FAD-binding, type 2, subdomain 1)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR016171(Vanillyl-alcohol oxidase, C-terminal subdomain 2)|interpro:IPR025650|interpro:IPR036318|mint:O00116|reactome:R-HSA-75896|reactome:R-HSA-9033241|reactome:R-HSA-9033500|interpro:IPR016166(FAD-binding, type 2) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:P8f6+j/f+WID0lFZnLIvVN5OSzM9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q6ZPD9 intact:EBI-6164519 intact:EBI-2871931|uniprotkb:Q68DC7|uniprotkb:Q6ZTS2|uniprotkb:Q6ZTB7|ensembl:ENSP00000376081|ensembl:ENSP00000344937 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:d19l3_human(display_long)|uniprotkb:DPY19L3(gene name)|psi-mi:DPY19L3(display_short)|uniprotkb:Dpy-19-like protein 3(gene name synonym)|uniprotkb:Protein dpy-19 homolog 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:XP_011524828.1|refseq:NP_001166245.1|refseq:NP_997208.2|ensembl:ENST00000342179(transcript)|ensembl:ENST00000392250(transcript)|go:"GO:0000030"(mannosyltransferase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018406"(protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan)|interpro:IPR018732|interpro:IPR030039|ensembl:ENSG00000178904(gene) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:N+hLBwy/nP3zdNXbr/GXW3V8AqI9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8IWZ3 intact:EBI-6164519 intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P28288 intact:EBI-6164519 intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16576 intact:EBI-6164519 intact:EBI-352227|ensembl:ENSP00000369427|intact:EBI-3505029|uniprotkb:Q5JP00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:rbbp7_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:RBAP46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_002884.1|ensembl:ENST00000380087(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q16576|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:7M3X|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8951664|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|ensembl:ENSG00000102054(gene)|refseq:NP_001185648.1|dip:DIP-436N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P21964 intact:EBI-6164519 intact:EBI-372265|uniprotkb:Q6IB07|uniprotkb:Q6ICE6|uniprotkb:A8MPV9|intact:EBI-743305|uniprotkb:Q9BWC7|intact:EBI-11576026|ensembl:ENSP00000354511|ensembl:ENSP00000384654|ensembl:ENSP00000385150|ensembl:ENSP00000385917|ensembl:ENSP00000503583|ensembl:ENSP00000503719|ensembl:ENSP00000504402 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:comt_human(display_long)|uniprotkb:COMT(gene name)|psi-mi:COMT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_000745.1|refseq:NP_001128633.1|refseq:NP_001128634.1|refseq:NP_009294.1|refseq:XP_016884083.1|refseq:XP_016884084.1|ensembl:ENSG00000093010(gene)|ensembl:ENST00000361682(transcript)|ensembl:ENST00000403710(transcript)|ensembl:ENST00000406520(transcript)|ensembl:ENST00000407537(transcript)|ensembl:ENST00000676678(transcript)|ensembl:ENST00000678255(transcript)|ensembl:ENST00000678868(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007612"(learning)|go:"GO:0007614"(short-term memory)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016036"(cellular response to phosphate starvation)|go:"GO:0016206"(catechol O-methyltransferase activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032259"(methylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032502"(developmental process)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042424"(catecholamine catabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0048265"(response to pain)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050668"(positive regulation of homocysteine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102084"(L-dopa O-methyltransferase activity)|go:"GO:0102938"(orcinol O-methyltransferase activity)|interpro:IPR002935(O-methyltransferase, family 3)|interpro:IPR017128(Catechol O-methyltransferase, eukaryotic)|interpro:IPR029063|mint:P21964|rcsb pdb:3A7E|rcsb pdb:3BWM|rcsb pdb:3BWY|rcsb pdb:4PYI|rcsb pdb:4PYJ|rcsb pdb:4PYK|rcsb pdb:4XUD|rcsb pdb:4XUE|rcsb pdb:5LSA|rcsb pdb:6I3C|rcsb pdb:6I3D|reactome:R-HSA-156581|reactome:R-HSA-379397|reactome:R-HSA-379398|reactome:R-HSA-9679191|rcsb pdb:4XUC psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:3Fnq8iVqPpOWNX6QQuiNRSsTFN09606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O14929 intact:EBI-6164519 intact:EBI-2339359|uniprotkb:Q53SU4|uniprotkb:Q53QF0|uniprotkb:Q49A44|uniprotkb:Q6P594|uniprotkb:Q8WWB9|ensembl:ENSP00000264108 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:hat1_human(display_long)|uniprotkb:HAT1(gene name)|psi-mi:HAT1(display_short)|uniprotkb:KAT1(gene name synonym)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003633.1|dip:DIP-52811N|ensembl:ENSG00000128708(gene)|ensembl:ENST00000264108(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006323"(DNA packaging)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0007584"(response to nutrient)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|mint:O14929|rcsb pdb:2P0W|rcsb pdb:6VO5|reactome:R-HSA-3214847 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:80KgRaid3NeRfAUdTHMQ/r0VuGo9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q96PU5 intact:EBI-6164519 intact:EBI-717962|uniprotkb:O43165|uniprotkb:Q7Z5F1|uniprotkb:Q7Z5F2|uniprotkb:Q7Z5N3|uniprotkb:Q8N5A7|uniprotkb:Q8WUU9|uniprotkb:Q9BW58|uniprotkb:Q9H2W4|uniprotkb:Q9NT88|uniprotkb:Q3LSM7|intact:EBI-28979180|ensembl:ENSP00000383199 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ned4l_human(display_long)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:NEDD4L(gene name)|psi-mi:NEDD4L(display_short)|uniprotkb:KIAA0439(gene name synonym)|uniprotkb:NEDL3(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001138436.1|refseq:NP_001138437.1|refseq:NP_001138438.1|refseq:NP_001138439.1|refseq:NP_001138440.1|refseq:NP_001138441.1|refseq:NP_001138442.1|refseq:NP_056092.2|refseq:NP_001230889.1|ensembl:ENSP00000383199|ensembl:ENSP00000372301|ensembl:ENST00000431212|ensembl:ENSP00000389406|ensembl:ENST00000435432|ensembl:ENSP00000393395|ensembl:ENST00000456173|ensembl:ENSP00000405440|ensembl:ENST00000456986|ensembl:ENSP00000411947|ensembl:ENST00000586263|ensembl:ENSP00000468546|ensembl:ENST00000674517|ensembl:ENSP00000501665|ensembl:ENST00000675502|ensembl:ENSP00000502428|ensembl:ENST00000675801|ensembl:ENSP00000502688|ensembl:ENST00000675865|ensembl:ENSP00000502003|ensembl:ENST00000676226|ensembl:ENSP00000502325|ensembl:ENST00000256830|ensembl:ENSP00000256830|ensembl:ENST00000356462|ensembl:ENSP00000348847|ensembl:ENST00000357895|ensembl:ENSP00000350569|ensembl:ENST00000382850|refseq:XP_016881168.1|refseq:NP_001138443.1|ensembl:ENSG00000049759(gene)|ensembl:ENST00000400345(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0010038"(response to metal ion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030104"(water homeostasis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:2LTY|rcsb pdb:2MPT|rcsb pdb:2NSQ|rcsb pdb:2ONI|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:5HPK|reactome:R-HSA-162588|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-2672351|reactome:R-HSA-983168|mint:Q96PU5|dip:DIP-41935N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:HrKtKY/e1+GYwm5PbBxMO+7XOc09606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y4B6 intact:EBI-6164519 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P43243 intact:EBI-6164519 intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9H4A6 intact:EBI-6164519 intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q14204 intact:EBI-6164519 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O00217 intact:EBI-6164519 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8TEB1 intact:EBI-6164519 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13409 intact:EBI-6164519 intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y6G9 intact:EBI-6164519 intact:EBI-2556107|uniprotkb:A2RRG7|uniprotkb:Q53HK7|uniprotkb:Q53HC8|ensembl:ENSP00000273130 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1l1_human(display_long)|uniprotkb:DNCLI1(gene name synonym)|uniprotkb:Dynein light intermediate chain 1, cytosolic(gene name synonym)|uniprotkb:Dynein light chain A(gene name synonym)|uniprotkb:DYNC1LI1(gene name)|psi-mi:DYNC1LI1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_057225.2|ensembl:ENSG00000144635(gene)|ensembl:ENST00000273130(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0051301"(cell division)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|mint:Q9Y6G9|rcsb pdb:6B9H|rcsb pdb:6PSD|rcsb pdb:6PSE|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0007018"(microtubule-based movement) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:LxQSfBpzuf6Acus2jBy0s53FdhU9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9BW61 intact:EBI-6164519 intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P17152 intact:EBI-6164519 intact:EBI-723946|ensembl:ENSP00000319992|intact:EBI-749474|uniprotkb:Q53YB2 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:tmm11_human(display_long)|uniprotkb:TMEM11(gene name)|psi-mi:TMEM11(display_short)|uniprotkb:C17orf35(gene name synonym)|uniprotkb:PM1(gene name synonym)|uniprotkb:Protein PM1(gene name synonym)|uniprotkb:Protein PMI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003867.1|ensembl:ENSG00000178307(gene)|ensembl:ENST00000317635(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR026120|mint:P17152|reactome:R-HSA-8949613 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:tQM/J4n5m5/8PH2niEtjBQY2xoY9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q5T8D3 intact:EBI-6164519 intact:EBI-4279983|uniprotkb:B3KQ56|uniprotkb:D3DRW0|uniprotkb:Q5T8D4|uniprotkb:Q5T8E1|uniprotkb:Q5T8E2|uniprotkb:Q86UV1|uniprotkb:Q8N6E3|uniprotkb:Q9UFB5|ensembl:ENSP00000365049 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:acbd5_human(display_long)|uniprotkb:ACBD5(gene name)|psi-mi:ACBD5(display_short)|uniprotkb:KIAA1996(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001035938.1|refseq:NP_663736.2|refseq:NP_001288180.1|refseq:NP_001288181.1|refseq:NP_001288182.1|ensembl:ENSG00000107897(gene)|ensembl:ENST00000375888(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016347(Membrane-associated diazepam binding inhibitor)|interpro:IPR022408|interpro:IPR035984|rcsb pdb:3FLV|reactome:R-HSA-390918|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798|refseq:XP_016872396.1|refseq:XP_016872397.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:o116xDV0fJe28E4BnL3ENXQxn1I9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16531 intact:EBI-6164519 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q96A33 intact:EBI-6164519 intact:EBI-720151|uniprotkb:Q96D00|uniprotkb:Q96JZ7|uniprotkb:Q9H3E4|uniprotkb:Q9NRG3|uniprotkb:B2RAS8|uniprotkb:D3DU20|ensembl:ENSP00000225726|ensembl:ENSP00000384888 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ccd47_human(display_long)|uniprotkb:CCDC47(gene name)|psi-mi:CCDC47(display_short)|uniprotkb:Calumin(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 47(gene name synonym)|uniprotkb:GK001(orf name)|uniprotkb:MSTP041(orf name)|uniprotkb:PSEC0077(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_064583.2|ensembl:ENSG00000108588(gene)|ensembl:ENST00000225726(transcript)|ensembl:ENST00000403162(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006983"(ER overload response)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043022"(ribosome binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045048"(protein insertion into ER membrane)|interpro:IPR012879(Protein of unknown function DUF1682)|mint:Q96A33|rcsb pdb:6W6L|go:"GO:0030867"(rough endoplasmic reticulum membrane)|refseq:XP_005257584.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:DdZFzZrrc4culfYoex0Czf/X6SQ9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13724 intact:EBI-6164519 intact:EBI-720141|uniprotkb:Q17RN9|uniprotkb:Q8TCT5|uniprotkb:A8K938|ensembl:ENSP00000410992|uniprotkb:F5H6D0 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:mogs_human(display_long)|uniprotkb:Processing A-glucosidase I(gene name synonym)|uniprotkb:MOGS(gene name)|psi-mi:MOGS(display_short)|uniprotkb:GCS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001139630.1|refseq:NP_006293.2|ensembl:ENSG00000115275(gene)|ensembl:ENST00000448666(transcript)|go:"GO:0004573"(Glc3Man9GlcNAc2 oligosaccharide glucosidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0015926"(glucosidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004888(Glycoside hydrolase, family 63)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR031335|interpro:IPR031631|interpro:IPR038518|mint:Q13724|reactome:R-HSA-4793954|reactome:R-HSA-532668|reactome:R-HSA-9683686|reactome:R-HSA-9694548 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:odbL3NUcP483ilKg/CMVn2GtdVs9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q5SW79 intact:EBI-6164519 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9NX00 intact:EBI-6164519 intact:EBI-2514588|ensembl:ENSP00000253047|uniprotkb:Q9BU41 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:tm160_human(display_long)|uniprotkb:TMEM160(gene name)|psi-mi:TMEM160(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175196|imex:IM-17346-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000130748(gene)|ensembl:ENST00000253047(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026801|refseq:NP_060324.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:5PuVgGSb9lQAD5/1RS6csGdai0Q9606 intact-crc:24A4A8725D7EEA5C|rigid:wJflx7XK+DnOardLCqy/C6KFLY8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9WB91 intact:EBI-6248147 intact:EBI-6164626 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:q9wb91_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|refseq:NP_057855.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:t82EXqHyi949gV+mcPObqkou7VU11706 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q86T03 intact:EBI-6248147 intact:EBI-6164623|uniprotkb:B2RA35|uniprotkb:Q86U09|uniprotkb:Q8WUC0|uniprotkb:Q9BU67|uniprotkb:Q9NSU8|ensembl:ENSP00000250489 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:pp4p1_human(display_long)|uniprotkb:PIP4P1(gene name)|psi-mi:PIP4P1(display_short)|uniprotkb:C14orf9(gene name synonym)|uniprotkb:PtdIns-4,5-P2 4-Ptase I(gene name synonym)|uniprotkb:TMEM55B(gene name synonym)|uniprotkb:Transmembrane protein 55B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSP00000250489|ensembl:ENST00000398020|ensembl:ENSP00000381102|refseq:NP_001094284.1|refseq:NP_653169.2|ensembl:ENSG00000165782(gene)|ensembl:ENST00000250489(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0070070"(proton-transporting V-type ATPase complex assembly)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR019178|reactome:R-HSA-6811555|reactome:R-HSA-8847453 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nbc8AvBd7g6bpNjfhhK7aPZ0BYk9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O14828 intact:EBI-6248147 intact:EBI-4401333|ensembl:ENSP00000307275|ensembl:ENSP00000461521|uniprotkb:A9Z1W6|uniprotkb:B1AVS6|uniprotkb:O15128|uniprotkb:Q96FR8|uniprotkb:Q9BPY0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:scam3_human(display_long)|uniprotkb:SCAMP3(gene name)|psi-mi:SCAMP3(display_short)|uniprotkb:C1orf3(gene name synonym)|uniprotkb:PROPIN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000116521(gene)|ensembl:ENSG00000263290(gene)|ensembl:ENST00000302631(transcript)|ensembl:ENST00000570831(transcript)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O14828|ensembl:ENSP00000307275|ensembl:ENST00000355379|ensembl:ENSP00000347540|ensembl:ENSP00000461521|ensembl:ENST00000573013|ensembl:ENSP00000458542|refseq:NP_005689.2|refseq:NP_443069.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:q1GaoVa7cLS2hGHVUM5Nv2oX4x09606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q5T9A4 intact:EBI-6248147 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UBB4 intact:EBI-6248147 intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P18859 intact:EBI-6248147 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9Y6D5 intact:EBI-6248147 intact:EBI-2837511|uniprotkb:Q9NTS1|uniprotkb:Q5TFT9|ensembl:ENSP00000360985 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:big2_human(display_long)|uniprotkb:ARFGEF2(gene name)|psi-mi:ARFGEF2(display_short)|uniprotkb:ARFGEP2(gene name synonym)|uniprotkb:BIG2(gene name synonym)|uniprotkb:ADP-ribosylation factor guanine nucleotide-exchange factor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_006411.2|ensembl:ENSG00000124198(gene)|ensembl:ENST00000371917(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005879"(axonemal microtubule)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0010256"(endomembrane system organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0055037"(recycling endosome)|interpro:IPR000904(SEC7-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032629|interpro:IPR032691|interpro:IPR035999|rcsb pdb:3L8N|rcsb pdb:3SWV|reactome:R-HSA-390471|go:"GO:0005794"(Golgi apparatus)|dip:DIP-48794N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:y64XGrD2XxX6vTmWOW0hbjDzDCk9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9HAV4 intact:EBI-6248147 intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9Y297 intact:EBI-6248147 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95197 intact:EBI-6248147 intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P20020 intact:EBI-6248147 intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:kCpUNLYDF38hciXj32D8rXbXULg9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95470 intact:EBI-6248147 intact:EBI-1046170|uniprotkb:Q7Z732|uniprotkb:Q9ULG8|uniprotkb:Q9UN89|uniprotkb:B2RBD4|ensembl:ENSP00000362298 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:sgpl1_human(display_long)|uniprotkb:Sphingosine-1-phosphate aldolase(gene name synonym)|uniprotkb:SGPL1(gene name)|psi-mi:SGPL1(display_short)|uniprotkb:KIAA1252(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003892.2|refseq:XP_011538618.1|refseq:XP_011538619.1|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010761"(fibroblast migration)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060325"(face morphogenesis)|ensembl:ENSG00000166224(gene)|go:"GO:0097190"(apoptotic signaling pathway)|ensembl:ENST00000373202(transcript)|interpro:IPR002129(Pyridoxal phosphate-dependent decarboxylase)|go:"GO:0001553"(luteinization)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006631"(fatty acid metabolic process)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008117"(sphinganine-1-phosphate aldolase activity)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:4Q6R|reactome:R-HSA-1660661|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|refseq:XP_005270320.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:hGut7nnomGA7QJhsV4lHBNm+kEE9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O14980 intact:EBI-6248147 intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q13616 intact:EBI-6248147 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q53GQ0 intact:EBI-6248147 intact:EBI-2963255|uniprotkb:Q96EA9|ensembl:ENSP00000278353|uniprotkb:A8K9B0|uniprotkb:Q9Y6G8|uniprotkb:Q96JU2|uniprotkb:D3DR23 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:dhb12_human(display_long)|uniprotkb:HSD17B12(gene name)|psi-mi:HSD17B12(display_short)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 12(gene name synonym)|uniprotkb:3-ketoacyl-CoA reductase(gene name synonym)|uniprotkb:SDR12C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 1(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000149084(gene)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008201"(heparin binding)|go:"GO:0009923"(fatty acid elongase complex)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0050062"(long-chain-fatty-acyl-CoA reductase activity)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|ensembl:ENST00000278353(transcript)|go:"GO:0102339"(3-oxo-arachidoyl-CoA reductase activity)|go:"GO:0102341"(3-oxo-lignoceroyl-CoA reductase activity)|go:"GO:0102342"(3-oxo-cerotoyl-CoA reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q53GQ0|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0102340"(3-oxo-behenoyl-CoA reductase activity)|refseq:NP_057226.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2R2pFY0c9yRuCvLU2J8n2urR+0o9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P55084 intact:EBI-6248147 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96P70 intact:EBI-6248147 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9HCU5 intact:EBI-6248147 intact:EBI-2553896|uniprotkb:Q9UH94|ensembl:ENSP00000260643|uniprotkb:Q53SZ8 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:preb_human(display_long)|uniprotkb:SEC12(gene name synonym)|uniprotkb:Mammalian guanine nucleotide exchange factor mSec12(gene name synonym)|uniprotkb:PREB(gene name)|psi-mi:PREB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_037520.1|ensembl:ENSG00000138073(gene)|ensembl:ENST00000260643(transcript)|go:"GO:0003400"(regulation of COPII vesicle coating)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0032527"(protein exit from endoplasmic reticulum)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051020"(GTPase binding)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|rcsb pdb:5TF2|reactome:R-HSA-204005|reactome:R-HSA-381038|reactome:R-HSA-5694530|refseq:NP_001317414.1|refseq:NP_001317415.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:3xjABrP1KtfZUMb/BSbe8ZN6dJ49606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NVI7 intact:EBI-6248147 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9Y6D6 intact:EBI-6248147 intact:EBI-1044254|uniprotkb:Q9NV46|uniprotkb:Q9UFV2|uniprotkb:Q9UNL0|ensembl:ENSP00000262215 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:big1_human(display_long)|uniprotkb:ARFGEF1(gene name)|psi-mi:ARFGEF1(display_short)|uniprotkb:ARFGEP1(gene name synonym)|uniprotkb:BIG1(gene name synonym)|uniprotkb:p200 ARF-GEP1(gene name synonym)|uniprotkb:p200 ARF guanine nucleotide exchange factor(gene name synonym)|uniprotkb:ADP-ribosylation factor guanine nucleotide-exchange factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000066777(gene)|ensembl:ENST00000262215(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007030"(Golgi organization)|go:"GO:0010256"(endomembrane system organization)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017022"(myosin binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090284"(positive regulation of protein glycosylation in Golgi)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032629|interpro:IPR032691|interpro:IPR035999|mint:Q9Y6D6|rcsb pdb:3LTL|rcsb pdb:5EE5|rcsb pdb:5J5C|go:"GO:0051897"(positive regulation of protein kinase B signaling)|refseq:NP_006412.2|refseq:XP_005251191.1|dip:DIP-29748N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:HIXdg7zEoEpHcC+KwTUjNFSgr5M9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P42704 intact:EBI-6248147 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9GZT3 intact:EBI-6248147 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P40939 intact:EBI-6248147 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UHQ9 intact:EBI-6248147 intact:EBI-953870|ensembl:ENSP00000356218|uniprotkb:A0PK21|uniprotkb:O95329|uniprotkb:Q53F73|uniprotkb:Q8NCL5|uniprotkb:Q9UHJ1|uniprotkb:B2R8E0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:nb5r1_human(display_long)|uniprotkb:"NAD(P)H:quinone oxidoreductase type 3 polypeptide A2"(gene name synonym)|uniprotkb:Humb5R2(gene name synonym)|uniprotkb:CYB5R1(gene name)|psi-mi:CYB5R1(display_short)|uniprotkb:NQO3A2(gene name synonym)|uniprotkb:UNQ3049/PRO9865(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000159348(gene)|ensembl:ENST00000367249(transcript)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071949"(FAD binding)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-HSA-114608|reactome:R-HSA-1237044|go:"GO:0016020"(membrane)|refseq:NP_057327.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:TOvJYSyfYu73Ac/SYjup+ABu74g9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q8IY95 intact:EBI-6248147 intact:EBI-4324723|uniprotkb:Q7Z3A1|uniprotkb:Q8N928|ensembl:ENSP00000305069 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:tm192_human(display_long)|uniprotkb:TMEM192(gene name)|psi-mi:TMEM192(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001093859.1|ensembl:ENSG00000170088(gene)|ensembl:ENST00000306480(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR029399|mint:Q8IY95 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:b2RQelAEDWcwiZ0w8/tgiEmeBX09606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q16537 intact:EBI-6248147 intact:EBI-968374|uniprotkb:B7ZAW5|uniprotkb:J3KQN6|ensembl:ENSP00000337641|uniprotkb:Q52LW4|uniprotkb:A4FU37|uniprotkb:B7ZKK8|intact:EBI-10962508|uniprotkb:B7ZKK9 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:2a5e_human(display_long)|uniprotkb:PPP2R5E(gene name)|psi-mi:PPP2R5E(display_short)|uniprotkb:PP2A B subunit isoform B'-epsilon(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-epsilon(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-epsilon(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-epsilon(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000154001(gene)|ensembl:ENST00000337537(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR016024(Armadillo-type fold)|mint:Q16537|reactome:R-HSA-141444|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-9648025|interpro:IPR011989(Armadillo-like helical)|refseq:NP_006237.1|refseq:NP_001269108.1|refseq:NP_001269109.1|refseq:NP_001269110.1|refseq:NP_001269111.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:m6vjnzx9eg+HpXrI2KKBLPbObzA9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q6P1M0 intact:EBI-6248147 intact:EBI-1052237|uniprotkb:O95186|uniprotkb:A8K2F7|uniprotkb:Q96G53|ensembl:ENSP00000300456 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:s27a4_human(display_long)|uniprotkb:Solute carrier family 27 member 4(gene name synonym)|uniprotkb:SLC27A4(gene name)|psi-mi:SLC27A4(display_short)|uniprotkb:ACSVL4(gene name synonym)|uniprotkb:FATP4(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase(gene name synonym)|uniprotkb:Very long-chain acyl-CoA synthetase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_005085.2|ensembl:ENSG00000167114(gene)|ensembl:ENST00000300456(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001579"(medium-chain fatty acid transport)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0015245"(fatty acid transmembrane transporter activity)|go:"GO:0015908"(fatty acid transport)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031957"(very long-chain fatty acid-CoA ligase activity)|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044381"(glucose import in response to insulin stimulus)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0062003"(negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity)|go:"GO:0090433"(palmitoyl-CoA ligase activity)|go:"GO:0090434"(oleoyl-CoA ligase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1990379"(lipid transport across blood-brain barrier)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|interpro:IPR022272|interpro:IPR025110|interpro:IPR030304|interpro:IPR042099|reactome:R-HSA-5619108|reactome:R-HSA-804914|refseq:XP_016869711.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0HD2kZ5IbnIpfLwEK1aFQesLQ289606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UKB1 intact:EBI-6248147 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95573 intact:EBI-6248147 intact:EBI-1190822|uniprotkb:Q60I92|uniprotkb:Q8IUM9|ensembl:ENSP00000350012|ensembl:ENSP00000375918|ensembl:ENSP00000504861|ensembl:ENSP00000504907|ensembl:ENSP00000505400|ensembl:ENSP00000505654|ensembl:ENSP00000505793|ensembl:ENSP00000505856|ensembl:ENSP00000505940|ensembl:ENSP00000506361|ensembl:ENSP00000506468|intact:EBI-21359981 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:acsl3_human(display_long)|uniprotkb:Long-chain acyl-CoA synthetase 3(gene name synonym)|uniprotkb:ACSL3(gene name)|psi-mi:ACSL3(display_short)|uniprotkb:ACS3(gene name synonym)|uniprotkb:FACL3(gene name synonym)|uniprotkb:LACS3(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase 3(gene name synonym)|uniprotkb:Medium-chain acyl-CoA ligase Acsl3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_004448.2|refseq:NP_976251.1|refseq:XP_016859073.1|ensembl:ENSG00000123983(gene)|ensembl:ENST00000357430(transcript)|ensembl:ENST00000392066(transcript)|ensembl:ENST00000679514(transcript)|ensembl:ENST00000679558(transcript)|ensembl:ENST00000680147(transcript)|ensembl:ENST00000680251(transcript)|ensembl:ENST00000680395(transcript)|ensembl:ENST00000680684(transcript)|ensembl:ENST00000680921(transcript)|ensembl:ENST00000681383(transcript)|ensembl:ENST00000681697(transcript)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:0090433"(palmitoyl-CoA ligase activity)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|mint:O95573|reactome:R-HSA-434313|reactome:R-HSA-75876 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:L5tCBPOlL45uh0aUFi4algZQ5nY9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P63208 intact:EBI-6248147 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NQC3 intact:EBI-6248147 intact:EBI-715945|intact:EBI-1753019|uniprotkb:O94962|uniprotkb:Q9BXG5|uniprotkb:Q9H212|uniprotkb:Q9H3I3|uniprotkb:Q9UQ42|uniprotkb:Q9Y293|uniprotkb:Q9Y2Y7|uniprotkb:Q9Y5U6|intact:EBI-1958210|intact:EBI-1056082|uniprotkb:Q7L7Q8|uniprotkb:Q96B16|intact:EBI-28967519|ensembl:ENSP00000337838|uniprotkb:Q7L7Q5|uniprotkb:Q7L7Q6|uniprotkb:Q8IUA4 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn4_human(display_long)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000317610|ensembl:ENSP00000322147|ensembl:ENSP00000337838|ensembl:ENST00000357376|ensembl:ENSP00000349944|ensembl:ENST00000357732|ensembl:ENSP00000350365|ensembl:ENST00000394609|ensembl:ENSP00000378107|ensembl:ENST00000394611|ensembl:ENSP00000378109|ensembl:ENST00000404909|ensembl:ENSP00000385650|ensembl:ENST00000405240|ensembl:ENSP00000384471|refseq:NP_008939.1|refseq:NP_065393.1|refseq:NP_722550.1|refseq:NP_997403.1|refseq:NP_997404.1|ensembl:ENSG00000115310(gene)|ensembl:ENST00000337526(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q9NQC3|rcsb pdb:2G31|rcsb pdb:2JV5|reactome:R-HSA-193634|refseq:XP_005264491.1|refseq:NP_001308788.1|refseq:NP_001308789.1|refseq:NP_001308790.1|refseq:NP_001308791.1|refseq:NP_001308792.1|refseq:NP_001308833.1|refseq:XP_016860007.1|refseq:XP_016860008.1|dip:DIP-42003N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:uhivTNOPdC7+q81CliY0Ozu0EwA9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q15843 intact:EBI-6248147 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q969Z0 intact:EBI-6248147 intact:EBI-702328|uniprotkb:O14710|uniprotkb:Q53GI8|uniprotkb:Q8NDM4|uniprotkb:Q9BUC6|uniprotkb:Q9Y2F6|uniprotkb:A4D2L2|uniprotkb:A4D2L3|uniprotkb:D3DVL5|uniprotkb:D3DVL6|ensembl:ENSP00000258770|ensembl:ENSP00000420597 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fakd4_human(display_long)|uniprotkb:Transforming growth factor beta regulator 4(gene name synonym)|uniprotkb:Cell cycle progression restoration protein 2(gene name synonym)|uniprotkb:TBRG4(gene name)|psi-mi:TBRG4(display_short)|uniprotkb:CPR2(gene name synonym)|uniprotkb:FASTKD4(gene name synonym)|uniprotkb:KIAA0948(gene name synonym)|uniprotkb:Protein TBRG4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_004740.2|refseq:NP_112162.1|refseq:NP_954573.1|ensembl:ENSG00000136270(gene)|ensembl:ENST00000258770(transcript)|ensembl:ENST00000494076(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090615"(mitochondrial mRNA processing)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|mint:Q969Z0 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2maj6VmOPUpSw5F+xJG2kfNKAc49606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P78357 intact:EBI-6248147 intact:EBI-1751903|ensembl:ENSP00000264638 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cntp1_human(display_long)|uniprotkb:CNTNAP1(gene name)|psi-mi:CNTNAP1(display_short)|uniprotkb:CASPR(gene name synonym)|uniprotkb:NRXN4(gene name synonym)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:p190(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003623.1|refseq:XP_016880727.1|ensembl:ENSG00000108797(gene)|ensembl:ENST00000264638(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:P78357|reactome:R-HSA-447043 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:ZNEoUJsmWmciH97yPBAegOqrO1E9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q8NCG7 intact:EBI-6248147 intact:EBI-721948|uniprotkb:B3KV90|uniprotkb:Q8N2N2|uniprotkb:Q8N9S1|uniprotkb:Q8TED3|uniprotkb:Q8WXE6|uniprotkb:Q6PIX3|uniprotkb:A4D2P3|uniprotkb:B4DQU0|ensembl:ENSP00000297056 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:dglb_human(display_long)|uniprotkb:KCCR13L(gene name synonym)|uniprotkb:DAGLB(gene name)|psi-mi:DAGLB(display_short)|uniprotkb:PUFA-specific triacylglycerol lipase(gene name synonym)|uniprotkb:Sn1-specific diacylglycerol lipase beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175288|imex:IM-17346-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001136408.1|refseq:NP_631918.3|ensembl:ENSG00000164535(gene)|ensembl:ENST00000297056(transcript)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0004806"(triglyceride lipase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007405"(neuroblast proliferation)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016298"(lipase activity)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0022008"(neurogenesis)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0047372"(acylglycerol lipase activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0071926"(endocannabinoid signaling pathway)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|interpro:IPR002921(Lipase, class 3)|interpro:IPR029058|reactome:R-HSA-426048|go:"GO:0005886"(plasma membrane) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:BSOQSeWHYhwhh1ngjrxrCkLO3fM9606 intact-crc:26C72F7DAAAE47E1|rigid:zq1R+MoqX/Ij11OoHJ8xOy+CGtU false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9HD40 intact:EBI-6163428 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175418|imex:IM-17346-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 intact-crc:8E76BEDC4A2080EE|rigid:+IVXEjSldNRA4/mn0enem035QKY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9Y6V7 intact:EBI-6163428 intact:EBI-719274|uniprotkb:Q53FJ1|uniprotkb:E7ENA0|uniprotkb:Q9BVQ8|ensembl:ENSP00000247003 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ddx49_human(display_long)|uniprotkb:DEAD box protein 49(gene name synonym)|uniprotkb:DDX49(gene name)|psi-mi:DDX49(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175418|imex:IM-17346-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_061943.2|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|ensembl:ENST00000247003(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006364"(rRNA processing)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9Y6V7|go:"GO:0030307"(positive regulation of cell growth)|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0044357"(regulation of rRNA stability)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|ensembl:ENSG00000105671(gene) psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:Yfej1zXpPTue3eewQcR5OpNILeM9606 intact-crc:8E76BEDC4A2080EE|rigid:+IVXEjSldNRA4/mn0enem035QKY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591 uniprotkb:Q9NTK5 intact:EBI-6163428 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175418|imex:IM-17346-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 intact-crc:8E76BEDC4A2080EE|rigid:+IVXEjSldNRA4/mn0enem035QKY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q99470 intact:EBI-6179761 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9UBS4 intact:EBI-6179761 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BRK5 intact:EBI-6179761 intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P14314 intact:EBI-6179761 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P28072 intact:EBI-6179761 intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q15165 intact:EBI-6179761 intact:EBI-3909798|ensembl:ENSP00000222572|ensembl:ENSP00000488838|uniprotkb:O15114|uniprotkb:B4DJD5|uniprotkb:Q5FBX7|uniprotkb:O15115|uniprotkb:B2RCP9|uniprotkb:Q86YL0|uniprotkb:O75856|uniprotkb:A4D1H7|intact:EBI-10966394 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pon2_human(display_long)|uniprotkb:PON2(gene name)|psi-mi:PON2(display_short)|uniprotkb:Aromatic esterase 2(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000105854(gene)|ensembl:ENST00000222572(transcript)|ensembl:ENST00000633531(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019439"(aromatic compound catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|interpro:IPR002640(Arylesterase)|interpro:IPR008364(Paraoxonase2)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|mint:Q15165|reactome:R-HSA-2142688|refseq:NP_000296.2|dip:DIP-61136N|refseq:NP_001018171.1 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:9zE87aut0R8eYxaXM+HgYsJxLYI9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P51665 intact:EBI-6179761 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O00231 intact:EBI-6179761 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9HCN8 intact:EBI-6179761 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q14697 intact:EBI-6179761 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175444|imex:IM-17346-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 psi-mi:"MI:0096"(pull down) chain-seq-start:33|chain-seq-end:511 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 intact-crc:45522BC1480E7222|rigid:hhqXFlXgUjo5oUbrjikU14Fwfqc false tandem tag:c-c("MI:0677")|mutation:21-21,62-62,160-160,183-183,192-192,314-314,438-438("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14697 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q07065 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P28072 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBV2 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9HCN8 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0096"(pull down) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P05067 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-77613|uniprotkb:P09000|uniprotkb:P78438|uniprotkb:Q13764|uniprotkb:Q13778|uniprotkb:Q13793|ensembl:ENSP00000284981|intact:EBI-28985182|uniprotkb:Q6GSC0|uniprotkb:Q8WZ99|uniprotkb:Q9UC33|uniprotkb:Q9UCC8|uniprotkb:Q9UCD1|uniprotkb:Q9UQ58|uniprotkb:Q16011|uniprotkb:Q16014|uniprotkb:Q16019|uniprotkb:Q16020|uniprotkb:Q9BT38|uniprotkb:Q9UCA9|uniprotkb:Q9UCB6|uniprotkb:B4DII8|uniprotkb:B2R5V1|uniprotkb:D3DSD1|uniprotkb:D3DSD2|uniprotkb:D3DSD3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:a4_human(display_long)|uniprotkb:APP(gene name)|psi-mi:APP(display_short)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:PreA4(gene name synonym)|uniprotkb:Cerebral vascular amyloid peptide(gene name synonym)|uniprotkb:Protease nexin-II(gene name synonym)|uniprotkb:APPI(gene name synonym)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0097645"(amylin binding)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0106003"(amyloid-beta complex)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900122"(positive regulation of receptor binding)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1903048"(regulation of acetylcholine-gated cation channel activity)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903523"(negative regulation of blood circulation)|go:"GO:1904022"(positive regulation of G protein-coupled receptor internalization)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044304"(main axon)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|ensembl:ENST00000346798(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000142192(gene)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0006897"(endocytosis)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0031904"(endosome lumen)|go:"GO:0051233"(spindle midzone)|go:"GO:0061903"(positive regulation of 1-phosphatidylinositol-3-kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1904399"(heparan sulfate binding)|rcsb pdb:2LZ4|rcsb pdb:2M4J|rcsb pdb:2M9R|rcsb pdb:2M9S|rcsb pdb:2MGT|rcsb pdb:2MJ1|rcsb pdb:2MPZ|rcsb pdb:2MVX|rcsb pdb:2MXU|rcsb pdb:2NAO|interpro:IPR036880|interpro:IPR037071|rcsb pdb:2OTK|rcsb pdb:2R0W|rcsb pdb:2WK3|rcsb pdb:2Y29|mint:P05067|rcsb pdb:1AAP|rcsb pdb:1AMB|rcsb pdb:1AMC|rcsb pdb:1AML|rcsb pdb:1BA4|rcsb pdb:1BA6|rcsb pdb:1BJB|rcsb pdb:1BJC|rcsb pdb:1BRC|rcsb pdb:1CA0|rcsb pdb:1HZ3|rcsb pdb:1IYT|rcsb pdb:1MWP|rcsb pdb:1OWT|rcsb pdb:1QCM|rcsb pdb:1QWP|rcsb pdb:1QXC|rcsb pdb:1QYT|rcsb pdb:1TAW|rcsb pdb:1TKN|rcsb pdb:1UO7|rcsb pdb:1UO8|rcsb pdb:1UOA|rcsb pdb:1UOI|rcsb pdb:1X11|rcsb pdb:1Z0Q|rcsb pdb:1ZE7|rcsb pdb:1ZE9|rcsb pdb:1ZJD|rcsb pdb:2BEG|rcsb pdb:2BOM|rcsb pdb:2BP4|rcsb pdb:2FJZ|rcsb pdb:2FK1|rcsb pdb:2FK2|rcsb pdb:2FK3|rcsb pdb:2FKL|rcsb pdb:2FMA|rcsb pdb:2G47|rcsb pdb:2IPU|rcsb pdb:2LFM|rcsb pdb:2LLM|rcsb pdb:2LMN|rcsb pdb:2LMO|rcsb pdb:2LMP|rcsb pdb:2LMQ|rcsb pdb:2LNQ|rcsb pdb:2LOH|rcsb pdb:2LP1|rcsb pdb:2LZ3|rcsb pdb:2Y2A|rcsb pdb:2Y3J|rcsb pdb:2Y3K|rcsb pdb:2Y3L|rcsb pdb:3AYU|rcsb pdb:3BAE|rcsb pdb:3BKJ|rcsb pdb:3DXC|rcsb pdb:3DXD|rcsb pdb:3DXE|rcsb pdb:3GCI|rcsb pdb:3IFL|rcsb pdb:3IFN|rcsb pdb:3IFO|rcsb pdb:3IFP|rcsb pdb:3JQ5|rcsb pdb:3JQL|rcsb pdb:3JTI|rcsb pdb:3KTM|rcsb pdb:3L33|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904591"(positive regulation of protein import)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905893"(positive regulation of cellular response to thapsigargin)|go:"GO:1905896"(positive regulation of cellular response to tunicamycin)|go:"GO:1905898"(positive regulation of response to endoplasmic reticulum stress)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990777"(lipoprotein particle)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|rcsb pdb:5HOY|rcsb pdb:5KK3|rcsb pdb:5LFY|rcsb pdb:5LV0|rcsb pdb:5MY4|rcsb pdb:5MYO|rcsb pdb:5MYX|rcsb pdb:5ONP|rcsb pdb:5ONQ|rcsb pdb:5OQV|rcsb pdb:5TXD|rcsb pdb:5VOS|rcsb pdb:5VZY|rcsb pdb:5W3P|rcsb pdb:6CO3|rcsb pdb:6GFI|rcsb pdb:6ITU|rcsb pdb:6IYC|rcsb pdb:6NB9|rcsb pdb:6O4J|rcsb pdb:6OC9|rcsb pdb:6OIZ|rcsb pdb:6RHY|rcsb pdb:6SHS|rcsb pdb:6SZF|rcsb pdb:6TI5|rcsb pdb:6TI6|rcsb pdb:6TI7|rcsb pdb:6W0O|rcsb pdb:6WXM|rcsb pdb:6YHF|rcsb pdb:6YHI|rcsb pdb:6YHO|rcsb pdb:6YHP|rcsb pdb:6YHX|rcsb pdb:7B3J|rcsb pdb:7B3K|rcsb pdb:7JXN|rcsb pdb:7JXO|rcsb pdb:7O1Q|reactome:R-HSA-114608|reactome:R-HSA-3000178|reactome:R-HSA-381426|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-432720|reactome:R-HSA-444473|reactome:R-HSA-445989|reactome:R-HSA-844456|reactome:R-HSA-879415|reactome:R-HSA-8862803|reactome:R-HSA-8957275|reactome:R-HSA-933542|reactome:R-HSA-9609523|reactome:R-HSA-9660826|reactome:R-HSA-977225|rcsb pdb:5AMB|rcsb pdb:5BUO|rcsb pdb:5C67|rcsb pdb:5CSZ|rcsb pdb:5HOW|rcsb pdb:5HOX|rcsb pdb:3L81|rcsb pdb:3MOQ|rcsb pdb:3MXC|rcsb pdb:3MXY|rcsb pdb:3NYJ|rcsb pdb:3NYL|rcsb pdb:3OVJ|rcsb pdb:3OW9|rcsb pdb:3PZZ|rcsb pdb:3Q2X|rcsb pdb:3SV1|rcsb pdb:3U0T|rcsb pdb:3UMH|rcsb pdb:3UMI|rcsb pdb:3UMK|rcsb pdb:4HIX|rcsb pdb:4JFN|rcsb pdb:4M1C|rcsb pdb:4MDR|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4NGE|rcsb pdb:4OJF|rcsb pdb:4ONF|rcsb pdb:4ONG|rcsb pdb:4PQD|rcsb pdb:4PWQ|rcsb pdb:4XXD|rcsb pdb:5AEF|rcsb pdb:5AM8|refseq:NP_000475.1|refseq:NP_001129601.1|refseq:NP_001129602.1|refseq:NP_001191230.1|refseq:NP_001191231.1|refseq:NP_001191232.1|refseq:NP_958816.1|refseq:NP_958817.1|ensembl:ENSP00000284981|ensembl:ENST00000348990|ensembl:ENSP00000345463|ensembl:ENST00000354192|ensembl:ENSP00000346129|ensembl:ENST00000357903|ensembl:ENSP00000350578|ensembl:ENST00000358918|ensembl:ENSP00000351796|ensembl:ENST00000440126|ensembl:ENSP00000387483|refseq:NP_001129488.1|refseq:NP_001129603.1|dip:DIP-574N psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:HatR8w8+mNjtjr7s5+bAwaStpmk9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P13073 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1056574|uniprotkb:B2R4J2|uniprotkb:D3DUM7|uniprotkb:Q6P666|ensembl:ENSP00000253452|ensembl:ENSP00000457015|ensembl:ENSP00000457513 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cox41_human(display_long)|uniprotkb:COX4I1(gene name)|psi-mi:COX4I1(display_short)|uniprotkb:COX4(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit IV isoform 1(gene name synonym)|uniprotkb:Cytochrome c oxidase polypeptide IV(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001852.1|refseq:NP_001305726.1|refseq:NP_001305731.1|refseq:NP_001305715.1|refseq:NP_001305717.1|refseq:NP_001305723.1|ensembl:ENSG00000131143(gene)|ensembl:ENST00000253452(transcript)|ensembl:ENST00000561569(transcript)|ensembl:ENST00000562336(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0007584"(response to nutrient)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004203(Cytochrome c oxidase subunit IV)|interpro:IPR013288(Cytochrome c oxidase subunit 4)|interpro:IPR036639|mint:P13073|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:7TbisLJIPPlFeZNNXqP9SciPjLw9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBS4 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0096"(pull down) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P45880 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P27824 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-355947|uniprotkb:D3DWQ3|uniprotkb:B2R5V8|ensembl:ENSP00000421434|ensembl:ENSP00000421813|ensembl:ENSP00000424063|ensembl:ENSP00000424745|ensembl:ENSP00000491760|ensembl:ENSP00000492372|ensembl:ENSP00000492868|ensembl:ENSP00000505013|ensembl:ENSP00000505202|ensembl:ENSP00000505526|ensembl:ENSP00000505960|ensembl:ENSP00000506003|ensembl:ENSP00000506021|ensembl:ENSP00000506061|ensembl:ENSP00000506078|ensembl:ENSP00000506509|ensembl:ENSP00000506568|ensembl:ENSP00000506583|ensembl:ENSP00000247461|ensembl:ENSP00000391646|intact:EBI-9513217|uniprotkb:B4DGP8|uniprotkb:B4E2T8|uniprotkb:D6R9K3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calx_human(display_long)|uniprotkb:CANX(gene name)|psi-mi:CANX(display_short)|uniprotkb:Major histocompatibility complex class I antigen-binding protein p88(gene name synonym)|uniprotkb:p90(gene name synonym)|uniprotkb:IP90(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001019820.1|refseq:NP_001737.1|refseq:XP_011532967.1|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27824|reactome:R-HSA-168316|reactome:R-HSA-2132295|reactome:R-HSA-8984722|reactome:R-HSA-901042|reactome:R-HSA-9020956|reactome:R-HSA-9683686|reactome:R-HSA-9694548|reactome:R-HSA-983170|ensembl:ENST00000452673(transcript)|ensembl:ENST00000502296(transcript)|ensembl:ENST00000504734(transcript)|ensembl:ENST00000509563(transcript)|ensembl:ENST00000513246(transcript)|ensembl:ENST00000638425(transcript)|ensembl:ENST00000638706(transcript)|ensembl:ENST00000639938(transcript)|ensembl:ENST00000680013(transcript)|ensembl:ENST00000680042(transcript)|ensembl:ENST00000680092(transcript)|ensembl:ENST00000680618(transcript)|ensembl:ENST00000681072(transcript)|ensembl:ENST00000681168(transcript)|ensembl:ENST00000681476(transcript)|ensembl:ENST00000681674(transcript)|ensembl:ENST00000681712(transcript)|ensembl:ENST00000681733(transcript)|ensembl:ENST00000681903(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|ensembl:ENST00000247461(transcript)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0009306"(protein secretion)|go:"GO:0016020"(membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|ensembl:ENSG00000127022(gene)|ensembl:ENSG00000283777(gene)|dip:DIP-457N psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Vy9HZjl19IXifyFpueW0LXi9ENk9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P25786 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-359352|uniprotkb:Q9BRV9|uniprotkb:A8K400|uniprotkb:Q53YE8|ensembl:ENSP00000379676 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:psa1_human(display_long)|uniprotkb:PSMA1(gene name)|psi-mi:PSMA1(display_short)|uniprotkb:PROS30(gene name synonym)|uniprotkb:PSC2(gene name synonym)|uniprotkb:Proteasome component C2(gene name synonym)|uniprotkb:Macropain subunit C2(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C2(gene name synonym)|uniprotkb:Proteasome nu chain(gene name synonym)|uniprotkb:30 kDa prosomal protein(gene name synonym)|uniprotkb:HC2(gene name synonym)|uniprotkb:NU(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002777.1|refseq:NP_683877.1|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000129084(gene)|ensembl:ENST00000396394(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002376"(immune system process)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR035144|mint:P25786|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|dip:DIP-29369N psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:tAADzZ1G9E/0BBeS8vybNx97v7k9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P27797 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q99470 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q15165 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-3909798|ensembl:ENSP00000222572|ensembl:ENSP00000488838|uniprotkb:O15114|uniprotkb:B4DJD5|uniprotkb:Q5FBX7|uniprotkb:O15115|uniprotkb:B2RCP9|uniprotkb:Q86YL0|uniprotkb:O75856|uniprotkb:A4D1H7|intact:EBI-10966394 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pon2_human(display_long)|uniprotkb:PON2(gene name)|psi-mi:PON2(display_short)|uniprotkb:Aromatic esterase 2(gene name synonym)|uniprotkb:Serum aryldialkylphosphatase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000105854(gene)|ensembl:ENST00000222572(transcript)|ensembl:ENST00000633531(transcript)|go:"GO:0004064"(arylesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009636"(response to toxic substance)|go:"GO:0019439"(aromatic compound catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0102007"(acyl-L-homoserine-lactone lactonohydrolase activity)|interpro:IPR002640(Arylesterase)|interpro:IPR008364(Paraoxonase2)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|mint:Q15165|reactome:R-HSA-2142688|refseq:NP_000296.2|dip:DIP-61136N|refseq:NP_001018171.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9zE87aut0R8eYxaXM+HgYsJxLYI9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P07237 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-395883|uniprotkb:P30037|uniprotkb:P32079|uniprotkb:Q15205|uniprotkb:Q6LDE5|uniprotkb:B2RDQ2|ensembl:ENSP00000327801 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pdia1_human(display_long)|uniprotkb:P4HB(gene name)|psi-mi:P4HB(display_short)|uniprotkb:PDI(gene name synonym)|uniprotkb:PDIA1(gene name synonym)|uniprotkb:PO4DB(gene name synonym)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:ERBA2L(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_000909.2|ensembl:ENSG00000185624(gene)|ensembl:ENST00000331483(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042470"(melanosome)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P07237|rcsb pdb:1BJX|rcsb pdb:1MEK|rcsb pdb:1X5C|rcsb pdb:2BJX|rcsb pdb:2K18|rcsb pdb:3BJ5|rcsb pdb:3UEM|rcsb pdb:4EKZ|rcsb pdb:4EL1|rcsb pdb:4JU5|rcsb pdb:6I7S|reactome:R-HSA-1650814|reactome:R-HSA-3299685|reactome:R-HSA-381426|reactome:R-HSA-5358346|reactome:R-HSA-8866423|reactome:R-HSA-8957275|reactome:R-HSA-8963888|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-32979N psi-mi:"MI:0096"(pull down) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:rh0B38TSfTX+lvU5OyBwEbVndFA9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9BYC5 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2869363|uniprotkb:Q9P2U6|uniprotkb:Q9P2U5|uniprotkb:O00235|uniprotkb:Q9BYC6|uniprotkb:B4DFS7|uniprotkb:G3V5N0|uniprotkb:Q8IUA5|ensembl:ENSP00000353910|ensembl:ENSP00000501213|ensembl:ENSP00000378087 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:fut8_human(display_long)|uniprotkb:FUT8(gene name)|psi-mi:FUT8(display_short)|uniprotkb:Fucosyltransferase 8(gene name synonym)|uniprotkb:"GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase"(gene name synonym)|uniprotkb:GDP-fucose--glycoprotein fucosyltransferase(gene name synonym)|uniprotkb:Glycoprotein 6-alpha-L-fucosyltransferase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_004471.4|refseq:NP_835368.1|refseq:NP_835369.1|ensembl:ENSG00000033170(gene)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6VLE|go:"GO:1900407"(regulation of cellular response to oxidative stress)|interpro:IPR001452(Src homology-3)|rcsb pdb:6X5H|interpro:IPR015827("Alpha-(1,6)-fucosyltransferase, eukaryotic type")|interpro:IPR027350|interpro:IPR035653|interpro:IPR036028|mint:Q9BYC5|rcsb pdb:2DE0|rcsb pdb:6VLD|rcsb pdb:6X5R|rcsb pdb:6X5S|rcsb pdb:6X5T|rcsb pdb:6X5U|reactome:R-HSA-9694548|reactome:R-HSA-975578|ensembl:ENST00000360689(transcript)|ensembl:ENST00000394586(transcript)|ensembl:ENST00000673929(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0006491"(N-glycan processing)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007585"(respiratory gaseous exchange by respiratory system)|go:"GO:0008424"(glycoprotein 6-alpha-L-fucosyltransferase activity)|go:"GO:0009312"(oligosaccharide biosynthetic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0019082"(viral protein processing)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033578"(protein glycosylation in Golgi)|go:"GO:0036071"(N-glycan fucosylation)|go:"GO:0042355"(L-fucose catabolic process)|go:"GO:0043112"(receptor metabolic process)|go:"GO:0046368"(GDP-L-fucose metabolic process)|go:"GO:0046921"("alpha-(1->6)-fucosyltransferase activity") psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:4ExQD5i1NzMB4ZN+jMDAgEDfXmg9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P14314 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175491|imex:IM-17346-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/04/06 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:5D2D68AFDABFB4C8|rigid:0zZbZfvYPyJcxWWns3QnFZG/HHQ false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9UBV2 intact:EBI-6179711 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96DZ1 intact:EBI-6179711 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9UJZ1 intact:EBI-6179711 intact:EBI-1044428|ensembl:ENSP00000348886|uniprotkb:O60376|uniprotkb:Q53G29|uniprotkb:Q96FY2|uniprotkb:Q9P042|uniprotkb:D3DRN3|uniprotkb:B4E1K7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:stml2_human(display_long)|uniprotkb:EPB72-like protein 2(gene name synonym)|uniprotkb:STOML2(gene name)|psi-mi:STOML2(display_short)|uniprotkb:SLP2(gene name synonym)|uniprotkb:HSPC108(orf name)|uniprotkb:Paraprotein target 7(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000165283(gene)|ensembl:ENST00000356493(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010876"(lipid localization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0035710"(CD4-positive, alpha-beta T cell activation)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051020"(GTPase binding)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1900210"(positive regulation of cardiolipin metabolic process)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1990046"(stress-induced mitochondrial fusion)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR032435|interpro:IPR036013|mint:Q9UJZ1|reactome:R-HSA-8949664|refseq:NP_001273960.1|refseq:NP_038470.1|refseq:NP_001273961.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:VH6uT4ShPg3IpPHbQtaSVXjZAYg9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P55072 intact:EBI-6179711 intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P49257 intact:EBI-6179711 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P21796 intact:EBI-6179711 intact:EBI-354158|uniprotkb:Q5FVE7|uniprotkb:Q9UIQ5|uniprotkb:Q9UPL0|uniprotkb:B3KVK4|uniprotkb:D3DQ93|ensembl:ENSP00000265333|ensembl:ENSP00000378484|ensembl:ENSP00000378487 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac1_human(display_long)|uniprotkb:VDAC1(gene name)|psi-mi:VDAC1(display_short)|uniprotkb:VDAC(gene name synonym)|uniprotkb:Outer mitochondrial membrane protein porin 1(gene name synonym)|uniprotkb:Plasmalemmal porin(gene name synonym)|uniprotkb:Porin 31HL(gene name synonym)|uniprotkb:Porin 31HM(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_003365.1|refseq:XP_005272132.1|refseq:XP_016865310.1|refseq:XP_016865311.1|refseq:XP_016865312.1|dip:DIP-32862N|ensembl:ENSG00000213585(gene)|ensembl:ENST00000265333(transcript)|ensembl:ENST00000395044(transcript)|ensembl:ENST00000395047(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005757"(mitochondrial permeability transition pore complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006090"(pyruvate metabolic process)|go:"GO:0006820"(anion transport)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007612"(learning)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097001"(ceramide binding)|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030270|mint:P21796|rcsb pdb:2JK4|rcsb pdb:2K4T|rcsb pdb:5JDP|rcsb pdb:5XDN|rcsb pdb:5XDO|rcsb pdb:6G6U|rcsb pdb:6G73|rcsb pdb:6TIQ|rcsb pdb:6TIR|reactome:R-HSA-1268020|reactome:R-HSA-5205685|reactome:R-HSA-5689880|reactome:R-HSA-70268|reactome:R-HSA-8949215 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:8Fqe6Ga3NmwwuICa4L45ga2i1nk9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P35232 intact:EBI-6179711 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P14854 intact:EBI-6179711 intact:EBI-1047480|uniprotkb:Q6IBL4|uniprotkb:B2R5C9|ensembl:ENSP00000376037|ensembl:ENSP00000466818|ensembl:ENSP00000497926 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cx6b1_human(display_long)|uniprotkb:COX6B1(gene name)|psi-mi:COX6B1(display_short)|uniprotkb:COX6B(gene name synonym)|uniprotkb:Cytochrome c oxidase subunit VIb isoform 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001854.1|ensembl:ENSG00000126267(gene)|ensembl:ENST00000392201(transcript)|ensembl:ENST00000592141(transcript)|ensembl:ENST00000649813(transcript)|go:"GO:0004129"(cytochrome-c oxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0021762"(substantia nigra development)|go:"GO:0045277"(respiratory chain complex IV)|interpro:IPR003213(Cytochrome c oxidase, subunit VIb)|interpro:IPR036549|rcsb pdb:5Z62|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:YuBPGRO9+EC9fWz+mWALa2DyZL89606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q99623 intact:EBI-6179711 intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:h4pib54mBeQgOKCe/hib58LM26w9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P45880 intact:EBI-6179711 intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:seQxCd19Z2HmpXcwb48osAuuafA9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q07065 intact:EBI-6179711 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O96008 intact:EBI-6179711 intact:EBI-1057581|uniprotkb:Q86VW4|uniprotkb:Q8WY09|uniprotkb:Q8WY10|uniprotkb:Q8WY11|uniprotkb:Q9BR95|uniprotkb:A0A024R0P9|ensembl:ENSP00000252487|ensembl:ENSP00000385184|ensembl:ENSP00000410339 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tom40_human(display_long)|uniprotkb:TOMM40(gene name)|psi-mi:TOMM40(display_short)|uniprotkb:PEREC1(gene name synonym)|uniprotkb:TOM40(gene name synonym)|uniprotkb:C19orf1(gene name synonym)|uniprotkb:Translocase of outer membrane 40 kDa subunit homolog(gene name synonym)|uniprotkb:Protein Haymaker(gene name synonym)|uniprotkb:p38.5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001122388.1|refseq:NP_001122389.1|refseq:NP_006105.1|ensembl:ENSG00000130204(gene)|ensembl:ENST00000252487(transcript)|ensembl:ENST00000405636(transcript)|ensembl:ENST00000426677(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006811"(ion transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0015288"(porin activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0046930"(pore complex)|interpro:IPR023614|interpro:IPR027246|interpro:IPR037930|rcsb pdb:7CK6|rcsb pdb:7CP9|reactome:R-HSA-1268020|reactome:R-HSA-5205685|go:"GO:0005741"(mitochondrial outer membrane) psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:BBV//Cb2ekmDNGHNrZuAXRgS++Y9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q12907 intact:EBI-6179711 intact:EBI-3915406|uniprotkb:Q53HH1|ensembl:ENSP00000303366 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman2_human(display_long)|uniprotkb:LMAN2(gene name)|psi-mi:LMAN2(display_short)|uniprotkb:C5orf8(gene name synonym)|uniprotkb:Glycoprotein GP36b(gene name synonym)|uniprotkb:Lectin mannose-binding 2(gene name synonym)|uniprotkb:Vesicular integral-membrane protein 36(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006807.1|ensembl:ENSG00000169223(gene)|ensembl:ENST00000303127(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035664|mint:Q12907|reactome:R-HSA-204005|reactome:R-HSA-5694530 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:goqUZGW9/lvVMWDAZS9csH3TqWY9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O75955 intact:EBI-6179711 intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y277 intact:EBI-6179711 intact:EBI-354196|uniprotkb:Q9UIS0|ensembl:ENSP00000022615 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vdac3_human(display_long)|uniprotkb:VDAC3(gene name)|psi-mi:VDAC3(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175559|imex:IM-17346-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001129166.1|refseq:NP_005653.3|ensembl:ENSG00000078668(gene)|ensembl:ENST00000022615(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015853"(adenine transport)|go:"GO:0016020"(membrane)|go:"GO:0046930"(pore complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030271|mint:Q9Y277|reactome:R-HSA-5689880|reactome:R-HSA-8949215 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:En6g89Dp+C4s1ArGYJyVfUBVsO09606 intact-crc:99929FB3BB3D0533|rigid:KJOpSuQIIANTSG0Wp9hUaxrQ7Q8 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P31946 intact:EBI-6248077 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:q76353_9hiv1(display_long) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P63104 intact:EBI-6248077 intact:EBI-347088|ensembl:ENSP00000309503|ensembl:ENSP00000379281|ensembl:ENSP00000379283|ensembl:ENSP00000379286|ensembl:ENSP00000379287|ensembl:ENSP00000379288|ensembl:ENSP00000395114|ensembl:ENSP00000398599|uniprotkb:P29213|uniprotkb:P29312|uniprotkb:Q32P43|uniprotkb:Q5XJ08|uniprotkb:Q6GPI2|uniprotkb:Q6IN74|uniprotkb:Q6NUR9|uniprotkb:Q6P3U9|uniprotkb:Q86V33|uniprotkb:A8K1N0|uniprotkb:B7Z465 psi-mi:q76353_9hiv1(display_long) psi-mi:1433z_human(display_long)|uniprotkb:YWHAZ(gene name)|psi-mi:YWHAZ(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENSG00000164924(gene)|ensembl:ENST00000353245(transcript)|ensembl:ENST00000395951(transcript)|ensembl:ENST00000395953(transcript)|ensembl:ENST00000395956(transcript)|ensembl:ENST00000395957(transcript)|ensembl:ENST00000395958(transcript)|ensembl:ENST00000419477(transcript)|ensembl:ENST00000457309(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031982"(vesicle)|go:"GO:0035148"(tube formation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072562"(blood microparticle)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|rcsb pdb:1IB1|rcsb pdb:1QJA|rcsb pdb:1QJB|rcsb pdb:2C1J|rcsb pdb:2C1N|rcsb pdb:2O02|rcsb pdb:2WH0|rcsb pdb:3CU8|mint:P63104|rcsb pdb:3NKX|rcsb pdb:3RDH|rcsb pdb:4BG6|rcsb pdb:4FJ3|rcsb pdb:4HKC|rcsb pdb:4IHL|rcsb pdb:4N7G|rcsb pdb:4N7Y|rcsb pdb:4N84|rcsb pdb:4WRQ|rcsb pdb:4ZDR|rcsb pdb:5D2D|rcsb pdb:5D3F|rcsb pdb:5EWZ|rcsb pdb:5EXA|rcsb pdb:5JM4|rcsb pdb:5M35|rcsb pdb:5M36|rcsb pdb:5M37|rcsb pdb:5NAS|rcsb pdb:5ULO|rcsb pdb:5WXN|rcsb pdb:5XY9|rcsb pdb:6EF5|rcsb pdb:6EJL|rcsb pdb:6EWW|rcsb pdb:6F08|rcsb pdb:6F09|rcsb pdb:6FN9|rcsb pdb:5J31|rcsb pdb:6FNA|rcsb pdb:6FNB|rcsb pdb:6FNC|rcsb pdb:6Q0K|rcsb pdb:6RLZ|rcsb pdb:6U2H|rcsb pdb:6XAG|rcsb pdb:6YMO|rcsb pdb:6YO8|rcsb pdb:6ZFD|rcsb pdb:6ZFG|rcsb pdb:7D8H|rcsb pdb:7D8P|rcsb pdb:7D9V|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-3769402|reactome:R-HSA-392517|reactome:R-HSA-430116|reactome:R-HSA-450604|reactome:R-HSA-512988|reactome:R-HSA-5625740|rcsb pdb:6YOS|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9013700|reactome:R-HSA-9604323|reactome:R-HSA-9614399|refseq:NP_001129171.1|refseq:NP_001129172.1|refseq:NP_001129173.1|refseq:NP_001129174.1|refseq:NP_003397.1|refseq:NP_663723.1|refseq:XP_005251118.1|refseq:XP_005251120.1|refseq:XP_016869299.1|refseq:XP_016869300.1|dip:DIP-563N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:70ZqFn0J1A7ykybulqWg4Ll21+U9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:O75155 intact:EBI-6248077 intact:EBI-5656182|uniprotkb:B9EGM9|uniprotkb:E9KL24|ensembl:ENSP00000387641 psi-mi:q76353_9hiv1(display_long) psi-mi:cand2_human(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 2(gene name synonym)|uniprotkb:KIAA0667(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa B(gene name synonym)|uniprotkb:TIP120B(gene name synonym)|uniprotkb:p120 CAND2(gene name synonym)|uniprotkb:CAND2(gene name)|psi-mi:CAND2(display_short)|uniprotkb:Epididymis tissue protein Li 169(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001155971.1|refseq:NP_036430.1|ensembl:ENSG00000144712(gene)|ensembl:ENST00000456430(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:O75155 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:LKo/B25pZVSPOAE+Yvk/ug1o7xY9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q8TEX9 intact:EBI-6248077 intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795 psi-mi:q76353_9hiv1(display_long) psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:O76071 intact:EBI-6248077 intact:EBI-725145|uniprotkb:A0MNN9|uniprotkb:Q53FM5|ensembl:ENSP00000418287 psi-mi:q76353_9hiv1(display_long) psi-mi:ciao1_human(display_long)|uniprotkb:WD repeat-containing protein 39(gene name synonym)|uniprotkb:CIAO1(gene name)|psi-mi:CIAO1(display_short)|uniprotkb:WDR39(gene name synonym)|uniprotkb:CIA1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_004795.1|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR028608|interpro:IPR036322|mint:O76071|rcsb pdb:3FM0|reactome:R-HSA-2564830|ensembl:ENSG00000144021(gene)|ensembl:ENST00000488633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer) psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:Lm4qlRM/4M+yz9miSayiAnBh5Dk9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q2T9J0 intact:EBI-6248077 intact:EBI-2510623|ensembl:ENSP00000287078|uniprotkb:Q8N6H2|uniprotkb:Q5SQU1|uniprotkb:Q96AR5|uniprotkb:Q5SQT4 psi-mi:q76353_9hiv1(display_long) psi-mi:tysd1_human(display_long)|uniprotkb:TYSND1(gene name)|psi-mi:TYSND1(display_short)|uniprotkb:Trypsin domain-containing protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENSG00000156521(gene)|ensembl:ENST00000287078(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0042802"(identical protein binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017345(Peptidase S1B, Tysnd1)|interpro:IPR039245|reactome:R-HSA-9033241|reactome:R-HSA-9033500|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001035363.1|refseq:NP_775826.2 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:nfBCzADhPAnpbY6GasKVCOaZjjs9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P15924 intact:EBI-6248077 intact:EBI-355041|uniprotkb:O75993|uniprotkb:Q14189|uniprotkb:Q9UHN4|uniprotkb:B2RTT2|uniprotkb:D7RX09|ensembl:ENSP00000369129 psi-mi:q76353_9hiv1(display_long) psi-mi:desp_human(display_long)|uniprotkb:DSP(gene name)|psi-mi:DSP(display_short)|uniprotkb:250/210 kDa paraneoplastic pemphigus antigen(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001305963.1|refseq:NP_001008844.1|refseq:NP_004406.2|go:"GO:0014704"(intercalated disc)|go:"GO:0005916"(fascia adherens)|go:"GO:0008544"(epidermis development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|ensembl:ENSG00000096696(gene)|ensembl:ENST00000379802(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:P15924|rcsb pdb:1LM5|rcsb pdb:1LM7|rcsb pdb:3R6N|rcsb pdb:5DZZ|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696273|dip:DIP-109N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:enapEqSoyTSLfPEQUAopkGpdxbo9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P12532 intact:EBI-6248077 intact:EBI-1050662|uniprotkb:Q0VAM3|uniprotkb:Q32NF6|uniprotkb:Q53FC4|uniprotkb:B4DIT8|uniprotkb:B7ZA09|ensembl:ENSP00000300283|ensembl:ENSP00000406577|ensembl:ENSP00000413165|ensembl:ENSP00000413255 psi-mi:q76353_9hiv1(display_long) psi-mi:kcru_human(display_long)|uniprotkb:Ubiquitous mitochondrial creatine kinase(gene name synonym)|uniprotkb:Acidic-type mitochondrial creatine kinase(gene name synonym)|uniprotkb:CKMT1A(gene name)|psi-mi:CKMT1A(display_short)|uniprotkb:CKMT(gene name synonym)|uniprotkb:CKMT1B(gene name)|psi-mi:CKMT1B(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001015001.1|refseq:NP_066270.1|refseq:NP_001308855.1|refseq:NP_001308856.1|refseq:NP_001308857.1|refseq:XP_016877858.1|refseq:XP_016877859.1|refseq:XP_011519496.1|refseq:XP_011519497.1|refseq:XP_011519498.1|refseq:XP_011519499.1|ensembl:ENSG00000223572(gene)|ensembl:ENSG00000237289(gene)|ensembl:ENST00000300283(transcript)|ensembl:ENST00000413453(transcript)|ensembl:ENST00000434505(transcript)|ensembl:ENST00000441322(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0046314"(phosphocreatine biosynthetic process)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12532|rcsb pdb:1QK1|reactome:R-HSA-71288 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:2ZgqE1XmbPXtjVY6lIdy+e0bSdU9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9H583 intact:EBI-6248077 intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541 psi-mi:q76353_9hiv1(display_long) psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9P2R7 intact:EBI-6248077 intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987 psi-mi:q76353_9hiv1(display_long) psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P13667 intact:EBI-6248077 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:q76353_9hiv1(display_long) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:P62258 intact:EBI-6248077 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:q76353_9hiv1(display_long) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9GZS3 intact:EBI-6248077 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:q76353_9hiv1(display_long) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q76353 uniprotkb:Q9Y263 intact:EBI-6248077 intact:EBI-1994037|uniprotkb:Q53EU5|uniprotkb:Q5VY33|uniprotkb:Q9NUL8|uniprotkb:Q9NVE9|uniprotkb:Q9UF53|uniprotkb:Q9Y5L1|ensembl:ENSP00000380460 psi-mi:q76353_9hiv1(display_long) psi-mi:plap_human(display_long)|uniprotkb:PLAA(gene name)|psi-mi:PLAA(display_short)|uniprotkb:PLAP(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175619|imex:IM-17346-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001026859.1|ensembl:ENSG00000137055(gene)|ensembl:ENST00000397292(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|interpro:IPR038122|mint:Q9Y263|rcsb pdb:2K89|rcsb pdb:2K8A|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:3EBB psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:SoClA00UzZpX9vV1cJWvefY6eY89606 intact-crc:70DE6C5FA995FB75|rigid:UUQYje/+NotUVq86dbn1ZvfYXL0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9HD40 intact:EBI-6179719 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q13155 intact:EBI-6179719 intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P07814 intact:EBI-6179719 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P26639 intact:EBI-6179719 intact:EBI-1042683|uniprotkb:Q96FP5|uniprotkb:Q9BWA6|uniprotkb:A8K8I1|ensembl:ENSP00000265112|ensembl:ENSP00000424387|uniprotkb:B4DEG8 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sytc_human(display_long)|uniprotkb:TARS1(gene name)|psi-mi:TARS1(display_short)|uniprotkb:TARS(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase(gene name synonym)|uniprotkb:Threonyl-tRNA synthetase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_689508.3|refseq:NP_001245367.1|rcsb pdb:4HWT|rcsb pdb:4P3N|rcsb pdb:4TTV|rcsb pdb:5XLN|reactome:R-HSA-379716|refseq:NP_001245366.1|go:"GO:0005829"(cytosol)|go:"GO:0006435"(threonyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002320(Threonyl-tRNA synthetase, class IIa)|interpro:IPR004095(TGS)|interpro:IPR004154(Anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|ensembl:ENSG00000113407(gene)|interpro:IPR012676(TGS-like)|ensembl:ENST00000265112(transcript)|ensembl:ENST00000502553(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004829"(threonine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR033728|interpro:IPR036621|mint:P26639|rcsb pdb:1WWT psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Z+rOaI1ZO1TQftfkRn1HhXUqDAk9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q12904 intact:EBI-6179719 intact:EBI-1045802|uniprotkb:Q6FG28|uniprotkb:Q96CQ9|uniprotkb:B4E1S7|uniprotkb:B3KTR2|ensembl:ENSP00000350699|ensembl:ENSP00000499850|ensembl:ENSP00000499921|ensembl:ENSP00000500025|ensembl:ENSP00000500159|ensembl:ENSP00000500170|ensembl:ENSP00000500620|ensembl:ENSP00000500668|ensembl:ENSP00000500732|ensembl:ENSP00000500794 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:aimp1_human(display_long)|uniprotkb:AIMP1(gene name)|psi-mi:AIMP1(display_short)|uniprotkb:EMAP2(gene name synonym)|uniprotkb:SCYE1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p43(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001135887.1|refseq:NP_001135888.1|refseq:NP_004748.2|ensembl:ENSG00000164022(gene)|ensembl:ENST00000358008(transcript)|ensembl:ENST00000671868(transcript)|ensembl:ENST00000671960(transcript)|ensembl:ENST00000672285(transcript)|ensembl:ENST00000672328(transcript)|ensembl:ENST00000672337(transcript)|ensembl:ENST00000672341(transcript)|ensembl:ENST00000672911(transcript)|ensembl:ENST00000673018(transcript)|ensembl:ENST00000673123(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051020"(GTPase binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070094"(positive regulation of glucagon secretion)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q12904|rcsb pdb:1E7Z|rcsb pdb:1EUJ|rcsb pdb:1FL0|rcsb pdb:4R3Z|reactome:R-HSA-2408522|reactome:R-HSA-379716|refseq:XP_016864324.1|refseq:XP_016864325.1 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:UtCeSRjFyuuEHUxVF2HkG9RA55k9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P49590 intact:EBI-6179719 intact:EBI-3909030|uniprotkb:B4DDY8|intact:EBI-10988212|ensembl:ENSP00000230771|ensembl:ENSP00000494296 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syhm_human(display_long)|uniprotkb:Histidyl-tRNA synthetase(gene name synonym)|uniprotkb:HARS2(gene name)|psi-mi:HARS2(display_short)|uniprotkb:HARSL(gene name synonym)|uniprotkb:HARSR(gene name synonym)|uniprotkb:HO3(gene name synonym)|uniprotkb:Histidine--tRNA ligase-like(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_036340.1|refseq:NP_001265660.1|refseq:NP_001265661.1|ensembl:ENSG00000112855(gene)|ensembl:ENST00000230771(transcript)|ensembl:ENST00000645749(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004821"(histidine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006427"(histidyl-tRNA aminoacylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004516(Histidyl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR015807(Histidyl-tRNA synthetase, class IIa, subgroup)|interpro:IPR033656|interpro:IPR036621|interpro:IPR041715|reactome:R-HSA-379726|go:"GO:0006412"(translation)|dip:DIP-59626N psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:pp4g+OJKxW3va88iXtfIAnGXMKw9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P41252 intact:EBI-6179719 intact:EBI-355303|uniprotkb:Q5TCD0|uniprotkb:Q9H588|uniprotkb:A8KAE9|uniprotkb:Q7Z3T4|ensembl:ENSP00000364794|ensembl:ENSP00000406448|ensembl:ENSP00000507144 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syic_human(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short)|uniprotkb:IARS(gene name synonym)|uniprotkb:Isoleucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_002152.2|refseq:NP_038203.2|ensembl:ENSG00000196305(gene)|ensembl:ENST00000375643(transcript)|ensembl:ENST00000443024(transcript)|ensembl:ENST00000683565(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004822"(isoleucine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006428"(isoleucyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002301(Isoleucyl-tRNA synthetase, class Ia)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR023586|interpro:IPR033709|mint:P41252|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:maAJX/O1Ryxr5NVFQEWvXNgHXyY9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q96I59 intact:EBI-6179719 intact:EBI-5455236|uniprotkb:G3V178|ensembl:ENSP00000281038 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:synm_human(display_long)|uniprotkb:NARS2(gene name)|psi-mi:NARS2(display_short)|uniprotkb:Asparaginyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_078954.4|refseq:NP_001230180.1|refseq:XP_016873792.1|ensembl:ENSG00000137513(gene)|ensembl:ENST00000281038(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004816"(asparagine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006421"(asparaginyl-tRNA aminoacylation)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004522(Asparaginyl-tRNA synthetase, class IIb)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|reactome:R-HSA-379726 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:8r61DYTijthPntztWKOxzbklcPY9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:O43324 intact:EBI-6179719 intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P14868 intact:EBI-6179719 intact:EBI-358730|uniprotkb:Q2TNI3|uniprotkb:Q32Q69|uniprotkb:Q53HV4|uniprotkb:Q53YC5|uniprotkb:Q9BW52|uniprotkb:Q68CR9|uniprotkb:A8K3J2|uniprotkb:D3DP77|ensembl:ENSP00000264161 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sydc_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 40 protein(gene name synonym)|uniprotkb:DARS(gene name synonym)|uniprotkb:PIG40(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001340.2|refseq:NP_001280241.1|ensembl:ENSG00000115866(gene)|ensembl:ENST00000264161(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P14868|rcsb pdb:4J15|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Yzpil/THkSHGR/ixVyQbV3RZz/E9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:O00560 intact:EBI-6179719 intact:EBI-727004|uniprotkb:O43391|ensembl:ENSP00000260130|ensembl:ENSP00000411771|uniprotkb:O00173|uniprotkb:Q14CP2|uniprotkb:B4DUH3|uniprotkb:B7ZLN2|uniprotkb:B2R5Q7 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sdcb1_human(display_long)|uniprotkb:Scaffold protein Pbp1(gene name synonym)|uniprotkb:Pro-TGF-alpha cytoplasmic domain-interacting protein 18(gene name synonym)|uniprotkb:Syndecan-binding protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 9(gene name synonym)|uniprotkb:SDCBP(gene name)|psi-mi:SDCBP(display_short)|uniprotkb:MDA9(gene name synonym)|uniprotkb:SYCL(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000137575(gene)|ensembl:ENST00000260130(transcript)|ensembl:ENST00000413219(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005109"(frizzled binding)|go:"GO:0005137"(interleukin-5 receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|refseq:NP_001007068.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005895"(interleukin-5 receptor complex)|go:"GO:0005912"(adherens junction)|refseq:NP_001007069.1|refseq:NP_001007070.1|refseq:NP_001007071.1|refseq:NP_005616.2|go:"GO:0005925"(focal adhesion)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR030528|interpro:IPR036034|go:"GO:0042802"(identical protein binding)|rcsb pdb:1N99|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:1NTE|go:"GO:0045121"(membrane raft)|rcsb pdb:1OBX|rcsb pdb:1OBY|rcsb pdb:1OBZ|go:"GO:0045202"(synapse)|go:"GO:0045545"(syndecan binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:1R6J|rcsb pdb:1V1T|rcsb pdb:1W9E|rcsb pdb:1W9O|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0099054"(presynapse assembly)|go:"GO:1903543"(positive regulation of exosomal secretion)|rcsb pdb:1W9Q|rcsb pdb:1YBO|rcsb pdb:4Z33|rcsb pdb:6R9H|rcsb pdb:6RLC|reactome:R-HSA-3928664|reactome:R-HSA-447043|reactome:R-HSA-5213460|reactome:R-HSA-6798695|reactome:R-HSA-5675482|dip:DIP-42705N psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Ys2RNVwH0n5AKA+rBULM9Foxccg9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P56192 intact:EBI-6179719 intact:EBI-355848|uniprotkb:Q14895|uniprotkb:Q53H14|uniprotkb:Q96A15|uniprotkb:Q96BZ0|uniprotkb:Q9NSE0|uniprotkb:B3KVK7|ensembl:ENSP00000262027 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:symc_human(display_long)|uniprotkb:MARS1(gene name)|psi-mi:MARS1(display_short)|uniprotkb:MARS(gene name synonym)|uniprotkb:Methionyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006431"(methionyl-tRNA aminoacylation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR000738(WHEP-TRS)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009068(S15/NS1, RNA-binding)|reactome:R-HSA-379716|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR014758(Methionyl-tRNA synthetase, class Ia, N-terminal)|interpro:IPR015413("Aminoacyl-tRNA synthetase, class I (M)")|interpro:IPR023458|interpro:IPR029038|interpro:IPR033911|interpro:IPR036282|interpro:IPR041598|interpro:IPR041872|mint:P56192|rcsb pdb:2DJV|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5GL7|rcsb pdb:5GOY|rcsb pdb:5Y6L|reactome:R-HSA-2408522|refseq:NP_004981.2|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000166986(gene)|ensembl:ENST00000262027(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004825"(methionine-tRNA ligase activity)|dip:DIP-38164N psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:qNZ6XqndlF5KRn/TWFDb5T1GjEc9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9NTK5 intact:EBI-6179719 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q14978 intact:EBI-6179719 intact:EBI-396155|uniprotkb:Q15030|intact:EBI-1055664|uniprotkb:Q9BUV3|uniprotkb:Q5VV70|ensembl:ENSP00000474710 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:nolc1_human(display_long)|uniprotkb:NOLC1(gene name)|psi-mi:NOLC1(display_short)|uniprotkb:KIAA0035(gene name synonym)|uniprotkb:Nucleolar 130 kDa protein(gene name synonym)|uniprotkb:140 kDa nucleolar phosphoprotein(gene name synonym)|uniprotkb:Nucleolar phosphoprotein p130(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 13(gene name synonym)|uniprotkb:NS5ATP13(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_004732.2|refseq:NP_001271317.1|refseq:NP_001271318.1|ensembl:ENSG00000166197(gene)|ensembl:ENST00000605788(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007000"(nucleolus organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0015030"(Cajal body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0062064"(box C/D snoRNP complex binding)|go:"GO:0062065"(box H/ACA snoRNP complex binding)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR007718(SRP40, C-terminal)|mint:Q14978 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:G3ClYMfSSjWsDzkxtahX5lLRzzQ9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q15046 intact:EBI-6179719 intact:EBI-356367|uniprotkb:A8MSK1|uniprotkb:Q9HB23|uniprotkb:O14946|uniprotkb:Q96J25|ensembl:ENSP00000303043|uniprotkb:D3DUK4 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syk_human(display_long)|uniprotkb:KARS1(gene name)|psi-mi:KARS1(display_short)|uniprotkb:KARS(gene name synonym)|uniprotkb:KIAA0070(gene name synonym)|uniprotkb:Lysyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001123561.1|refseq:NP_005539.1|go:"GO:0016597"(amino acid binding)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0005739"(mitochondrion)|go:"GO:0070371"(ERK1 and ERK2 cascade)|interpro:IPR002313(Lysyl-tRNA synthetase, class II)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018149|go:"GO:0005759"(mitochondrial matrix)|interpro:IPR034762|interpro:IPR044136|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|mint:Q15046|go:"GO:0006430"(lysyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|rcsb pdb:3BJU|rcsb pdb:4DPG|go:"GO:0010165"(response to X-ray)|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:6CHD|rcsb pdb:6ILD|rcsb pdb:6ILH|rcsb pdb:7EA9|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|ensembl:ENSG00000065427(gene)|ensembl:ENST00000302445(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002276"(basophil activation involved in immune response)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0003877"(ATP adenylyltransferase activity)|go:"GO:0004824"(lysine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|dip:DIP-29725N psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:YLjIdoUW7DiNp+Pj1OPg8jhnC5w9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P54136 intact:EBI-6179719 intact:EBI-355482|uniprotkb:Q9BWA1|uniprotkb:B2RBS9|uniprotkb:Q53GY4|intact:EBI-28985219|ensembl:ENSP00000231572 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syrc_human(display_long)|uniprotkb:RARS1(gene name)|psi-mi:RARS1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:RARS(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_002878.2|ensembl:ENSG00000113643(gene)|ensembl:ENST00000231572(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:P54136|rcsb pdb:4Q2T|rcsb pdb:4Q2X|rcsb pdb:4Q2Y|rcsb pdb:4R3Z|rcsb pdb:4ZAJ|reactome:R-HSA-2408522|reactome:R-HSA-379716|ensembl:ENSP00000231572 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:oM9gWF1NucjgVjBFm4DcjmnQNCE9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P47897 intact:EBI-6179719 intact:EBI-347462|uniprotkb:B4DWJ2|ensembl:ENSP00000307567 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syq_human(display_long)|uniprotkb:QARS1(gene name)|psi-mi:QARS1(display_short)|uniprotkb:Glutaminyl-tRNA synthetase(gene name synonym)|uniprotkb:QARS(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_005042.1|ensembl:ENSG00000172053(gene)|ensembl:ENST00000306125(transcript)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR004514(Glutaminyl-tRNA synthetase, class Ic)|interpro:IPR007638(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 2)|interpro:IPR007639(Glutaminyl-tRNA synthetase, class Ic, non-specific RNA-binding region part 1)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR042558|interpro:IPR042559|mint:P47897|rcsb pdb:4R3Z|rcsb pdb:4YE6|rcsb pdb:4YE8|rcsb pdb:4YE9|reactome:R-HSA-2408522|go:"GO:0006469"(negative regulation of protein kinase activity)|reactome:R-HSA-379716|reactome:R-HSA-379726|go:"GO:0007420"(brain development)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032873"(negative regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_001259002.1 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:3Q8LR+aWJJue/ixtD3ZYDpC/D3o9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9P2J5 intact:EBI-6179719 intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175673|imex:IM-17346-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606 intact-crc:9E753D6B556DA7ED|rigid:YwYoesfg8W7GgvxHtSkKdjXqYkg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:O14734 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175772|imex:IM-17346-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity) psi-mi:"MI:0096"(pull down) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606 intact-crc:4778AC6AAE4F3B5D|rigid:tMokFoF5t2q+fQ4gkX9K5DjcFpE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P30419 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-5280164|uniprotkb:A8K7C1|uniprotkb:Q9UE09|ensembl:ENSP00000258960|ensembl:ENSP00000468424|ensembl:ENSP00000504192 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:nmt1_human(display_long)|uniprotkb:NMT1(gene name)|psi-mi:NMT1(display_short)|uniprotkb:NMT(gene name synonym)|uniprotkb:"Myristoyl-CoA:protein N-myristoyltransferase 1"(gene name synonym)|uniprotkb:Peptide N-myristoyltransferase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175772|imex:IM-17346-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_066565.1|ensembl:ENSG00000136448(gene)|ensembl:ENST00000258960(transcript)|ensembl:ENST00000592782(transcript)|ensembl:ENST00000676828(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004379"(glycylpeptide N-tetradecanoyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0018008"(N-terminal peptidyl-glycine N-myristoylation)|go:"GO:0019107"(myristoyltransferase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0042180"(cellular ketone metabolic process)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR000903("Myristoyl-CoA:protein N-myristoyltransferase")|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR022676|interpro:IPR022677|interpro:IPR022678|rcsb pdb:1RXT|rcsb pdb:3IU1|rcsb pdb:3IU2|rcsb pdb:3IWE|rcsb pdb:3JTK|rcsb pdb:4C2Y|rcsb pdb:4C2Z|rcsb pdb:5MU6|rcsb pdb:5NPQ|rcsb pdb:5O6H|rcsb pdb:5O6J|rcsb pdb:5O9S|rcsb pdb:5O9T|rcsb pdb:5O9U|rcsb pdb:5O9V|rcsb pdb:5UUT|rcsb pdb:6EHJ|rcsb pdb:6F56|rcsb pdb:6FZ2|rcsb pdb:6FZ3|rcsb pdb:6FZ5|rcsb pdb:6PAV|rcsb pdb:6QRM|rcsb pdb:6SJZ|rcsb pdb:6SK2|rcsb pdb:6SK3|rcsb pdb:6SK8|rcsb pdb:6SKJ|reactome:R-HSA-162599|reactome:R-HSA-2514859|reactome:R-HSA-75108|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0096"(pull down) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:eVkADRJp/cg4xIAw0ymeUZ+Vwyk9606 intact-crc:4778AC6AAE4F3B5D|rigid:tMokFoF5t2q+fQ4gkX9K5DjcFpE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9NXG2 intact:EBI-6179727 intact:EBI-5462248|uniprotkb:Q9BWC3|ensembl:ENSP00000370741|ensembl:ENSP00000379392|ensembl:ENSP00000490841 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:thum1_human(display_long)|uniprotkb:THUMPD1(gene name)|psi-mi:THUMPD1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175742|imex:IM-17346-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001291479.1|refseq:NP_060206.2|refseq:XP_016878922.1|ensembl:ENSG00000066654(gene)|rcsb pdb:2DIR|ensembl:ENST00000381337(transcript)|ensembl:ENST00000396083(transcript)|ensembl:ENST00000636554(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006400"(tRNA modification)|interpro:IPR004114(THUMP)|interpro:IPR040183|reactome:R-HSA-6790901 psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:d1NzKlB+M6nlf/QjfaZ2Occv2Fo9606 intact-crc:B2DCF29AD9A97C89|rigid:dIbYeVsQhz1It4WkzDIp2PwWZTM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9UGY1 intact:EBI-6179727 intact:EBI-716098|ensembl:ENSP00000352021|ensembl:ENSP00000403059|ensembl:ENSP00000482349 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:nol12_human(display_long)|uniprotkb:NOL12(gene name)|psi-mi:NOL12(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175742|imex:IM-17346-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_077289.1|ensembl:ENSG00000273899(gene)|ensembl:ENST00000359114(transcript)|ensembl:ENST00000438329(transcript)|ensembl:ENST00000611699(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0019843"(rRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR019186|reactome:R-HSA-6791226 psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:yYrOadt76SuArmi4/Wfj2rFguNQ9606 intact-crc:B2DCF29AD9A97C89|rigid:dIbYeVsQhz1It4WkzDIp2PwWZTM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9UI47 intact:EBI-6179727 intact:EBI-3937546|uniprotkb:Q6P056|uniprotkb:Q5VSR2|ensembl:ENSP00000389714|ensembl:ENSP00000508047|ensembl:ENSP00000508371 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ctna3_human(display_long)|uniprotkb:CTNNA3(gene name)|psi-mi:CTNNA3(display_short)|uniprotkb:Alpha T-catenin(gene name synonym)|uniprotkb:Cadherin-associated protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175742|imex:IM-17346-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000183230(gene)|ensembl:ENST00000433211(transcript)|ensembl:ENST00000682758(transcript)|ensembl:ENST00000684154(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|refseq:NP_001120856.1|refseq:NP_037398.2 psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:lN7D/dH5lMAkRUKOIXZkdvZSK9E9606 intact-crc:B2DCF29AD9A97C89|rigid:dIbYeVsQhz1It4WkzDIp2PwWZTM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q9Y3B7 intact:EBI-6179727 intact:EBI-5453723|ensembl:ENSP00000308897|uniprotkb:A8K219|uniprotkb:Q32P46|uniprotkb:Q96Q73|uniprotkb:A6NLT0 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:rm11_human(display_long)|uniprotkb:MRPL11(gene name)|psi-mi:MRPL11(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL11m(gene name synonym)|uniprotkb:CGI-113(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175742|imex:IM-17346-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000174547(gene)|ensembl:ENST00000310999(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR006519(Ribosomal protein L11, bacterial-type)|interpro:IPR020783|interpro:IPR020784|interpro:IPR036769|interpro:IPR036796|mint:Q9Y3B7|refseq:NP_057134.1|refseq:NP_733934.1|refseq:NP_733935.1|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6NU3|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:eTr4vzze0vg1fxw97n9C/lXYssU9606 intact-crc:B2DCF29AD9A97C89|rigid:dIbYeVsQhz1It4WkzDIp2PwWZTM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:P55769 intact:EBI-6179727 intact:EBI-712228|ensembl:ENSP00000215956|ensembl:ENSP00000383949|ensembl:ENSP00000497142 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:nh2l1_human(display_long)|uniprotkb:SNU13(gene name)|psi-mi:SNU13(display_short)|uniprotkb:High mobility group-like nuclear protein 2 homolog 1(gene name synonym)|uniprotkb:NHP2L1(gene name synonym)|uniprotkb:OTK27(gene name synonym)|uniprotkb:SNU13 homolog(gene name synonym)|uniprotkb:U4/U6.U5 small nuclear ribonucleoprotein SNU13(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP 15.5 kDa protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175742|imex:IM-17346-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000100138(gene)|ensembl:ENST00000215956(transcript)|ensembl:ENST00000401959(transcript)|ensembl:ENST00000648674(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0007338"(single fertilization)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051117"(ATPase binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P55769|rcsb pdb:1E7K|rcsb pdb:2JNB|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_001003796.1|refseq:NP_004999.1 psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:ZMkqsDfMCrTlT/kJxillOA8839E9606 intact-crc:B2DCF29AD9A97C89|rigid:dIbYeVsQhz1It4WkzDIp2PwWZTM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038596 uniprotkb:P13489 intact:EBI-6179727 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175742|imex:IM-17346-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 intact-crc:B2DCF29AD9A97C89|rigid:dIbYeVsQhz1It4WkzDIp2PwWZTM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15371 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9H4L5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O00303 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UGP4 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15372 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q08380 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354956|ensembl:ENSP00000262776|uniprotkb:Q7M4S0|uniprotkb:Q9UCH8|uniprotkb:Q9UCH9|uniprotkb:Q9UCI0 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:lg3bp_human(display_long)|uniprotkb:LGALS3BP(gene name)|psi-mi:LGALS3BP(display_short)|uniprotkb:M2BP(gene name synonym)|uniprotkb:Lectin galactoside-binding soluble 3-binding protein(gene name synonym)|uniprotkb:Mac-2-binding protein(gene name synonym)|uniprotkb:Tumor-associated antigen 90K(gene name synonym)|uniprotkb:Basement membrane autoantigen p105(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000108679(gene)|ensembl:ENST00000262776(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031089"(platelet dense granule lumen)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR017448(Speract/scavenger receptor related)|go:"GO:0007155"(cell adhesion)|interpro:IPR036772|mint:Q08380|rcsb pdb:1BY2|rcsb pdb:6GFB|reactome:R-HSA-114608|refseq:NP_005558.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:1LIu+jrlwe2RGkR31frIXz8Ixec9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P46063 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2823728|uniprotkb:A8K6G2|ensembl:ENSP00000395449|ensembl:ENSP00000416739 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:recq1_human(display_long)|uniprotkb:RECQL(gene name)|psi-mi:RECQL(display_short)|uniprotkb:RECQ1(gene name synonym)|uniprotkb:RECQL1(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 1(gene name synonym)|uniprotkb:DNA-dependent ATPase Q1(gene name synonym)|uniprotkb:RecQ protein-like 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_002898.2|refseq:NP_116559.1|ensembl:ENSG00000004700(gene)|ensembl:ENST00000421138(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0016020"(membrane)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|mint:P46063|rcsb pdb:2V1X|rcsb pdb:2WWY|rcsb pdb:4U7D|rcsb pdb:6JTZ|ensembl:ENST00000444129(transcript)|refseq:XP_005253518.1|refseq:XP_005253519.1|refseq:XP_005253520.1|refseq:XP_005253521.1|dip:DIP-29216N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:zJXPLIWtbjvhAhWH0HN+qdkCCOg9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P13667 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q5T4S7 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:8Iown8oj965YAir+95+3om5+1YM9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q15293 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-948278|ensembl:ENSP00000054950|uniprotkb:D3DR00|uniprotkb:B7Z1M1 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:rcn1_human(display_long)|uniprotkb:RCN1(gene name)|psi-mi:RCN1(display_short)|uniprotkb:RCN(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG reactome:R-HSA-8957275|reactome:R-HSA-381426|ensembl:ENSG00000049449(gene)|ensembl:ENST00000054950(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q15293|refseq:NP_002892.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ynhvrXX2fQ7Dn1LT+mp2PKm0bc89606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P62714 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q13347 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:fogC6nSNmIynV2ziHZboT9laA3M9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q14152 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P55884 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q99613 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y262 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O75821 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366632|uniprotkb:O14801|uniprotkb:Q969U5|intact:EBI-28974438|ensembl:ENSP00000253108 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3g_human(display_long)|uniprotkb:EIF3G(gene name)|psi-mi:EIF3G(display_short)|uniprotkb:EIF3S4(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 4(gene name synonym)|uniprotkb:eIF-3-delta(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 RNA-binding subunit(gene name synonym)|uniprotkb:eIF3 p44(gene name synonym)|uniprotkb:eIF3 p42(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSP00000253108|refseq:NP_003746.2|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017334(Translation initiation factor 3, RNA-binding subunit)|interpro:IPR024675|interpro:IPR034240|interpro:IPR035979|mint:O75821|rcsb pdb:2CQ0|rcsb pdb:2MJC|rcsb pdb:5K0Y|rcsb pdb:6YBS|rcsb pdb:6ZMW|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|ensembl:ENSG00000130811(gene)|ensembl:ENST00000253108(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|dip:DIP-31115N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:ZHm8Il08Zyb6kFAavZo4tnuUN4g9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UBQ5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P60228 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175807|imex:IM-17346-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:991EF898D561BAC6|rigid:xyGDOY7DIARFYFx3OpGVFwXlazU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q92805 intact:EBI-6248094 intact:EBI-6164177|ensembl:ENSP00000362656|uniprotkb:Q5T164|uniprotkb:Q8IYZ9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:goga1_human(display_long)|uniprotkb:GOLGA1(gene name)|psi-mi:GOLGA1(display_short)|uniprotkb:Golgin-97(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000136935(gene)|ensembl:ENST00000373555(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|refseq:NP_002068.1|refseq:XP_006717125.1|refseq:XP_006717126.1|refseq:XP_005251986.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:5SRVVvNxZ7PikOK9zV4HypxK8i49606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9BU89 intact:EBI-6248094 intact:EBI-6164171|ensembl:ENSP00000398882|ensembl:ENSP00000500806|uniprotkb:O75265 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dohh_human(display_long)|uniprotkb:DOHH(gene name)|psi-mi:DOHH(display_short)|uniprotkb:Deoxyhypusine dioxygenase(gene name synonym)|uniprotkb:Deoxyhypusine monooxygenase(gene name synonym)|uniprotkb:HEAT-like repeat-containing protein 1(gene name synonym)|uniprotkb:HLRC1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000129932(gene)|ensembl:ENST00000427575(transcript)|ensembl:ENST00000672935(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0008612"(peptidyl-lysine modification to peptidyl-hypusine)|go:"GO:0019135"(deoxyhypusine monooxygenase activity)|interpro:IPR004155(PBS lyase HEAT-like repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR027517|rcsb pdb:4D4Z|rcsb pdb:4D50|reactome:R-HSA-204626|go:"GO:0016491"(oxidoreductase activity)|refseq:NP_001138637.1|refseq:NP_112594.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:l0UcUgujKCQ4M7OAYNTaXxIl2M49606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P43246 intact:EBI-6248094 intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q14152 intact:EBI-6248094 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q7L2H7 intact:EBI-6248094 intact:EBI-353901|intact:EBI-4289539|intact:EBI-715219|uniprotkb:Q2F836|uniprotkb:Q53HL6|uniprotkb:Q9BXW1|uniprotkb:O60735|uniprotkb:A8K7X4|intact:EBI-2559366|ensembl:ENSP00000436049|intact:EBI-373200|uniprotkb:B4E2Q4 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3m_human(display_long)|uniprotkb:EIF3M(gene name)|psi-mi:EIF3M(display_short)|uniprotkb:HFLB5(gene name synonym)|uniprotkb:PCID1(gene name synonym)|uniprotkb:PCI domain-containing protein 1(gene name synonym)|uniprotkb:Fetal lung protein B5(gene name synonym)|uniprotkb:GA17(orf name)|uniprotkb:PNAS-125(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006351.2|refseq:NP_001294858.1|ensembl:ENSG00000149100(gene)|ensembl:ENST00000531120(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027528|interpro:IPR036390|interpro:IPR040750|mint:Q7L2H7|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31256N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:siTfTDezqWL90pw6xG3xUKfY9n49606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q32P44 intact:EBI-6248094 intact:EBI-1046713|uniprotkb:Q6ZQW7|uniprotkb:Q8NA55|ensembl:ENSP00000378254|intact:EBI-2556256 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:emal3_human(display_long)|uniprotkb:EML3(gene name)|psi-mi:EML3(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 intact:EBI-1058671(primary-reference)|go:"GO:0015630"(microtubule cytoskeleton)|ensembl:ENSG00000149499(gene)|ensembl:ENST00000394773(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR001680(WD40 repeat)|interpro:IPR005108(HELP)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|refseq:NP_694997.2|refseq:NP_001287722.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Q5NalpeOEiROb0QG6vDt/b0Sna49606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H1A4 intact:EBI-6248094 intact:EBI-395918|uniprotkb:Q2M3H8|uniprotkb:Q9BSE6|uniprotkb:Q9H8D0|ensembl:ENSP00000339109 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:apc1_human(display_long)|uniprotkb:ANAPC1(gene name)|psi-mi:ANAPC1(display_short)|uniprotkb:TSG24(gene name synonym)|uniprotkb:Cyclosome subunit 1(gene name synonym)|uniprotkb:Testis-specific gene 24 protein(gene name synonym)|uniprotkb:Mitotic checkpoint regulator(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_073153.1|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENSG00000153107(gene)|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|ensembl:ENST00000341068(transcript)|go:"GO:0005654"(nucleoplasm)|rcsb pdb:5L9U|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:5LCW|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|rcsb pdb:5LGG|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070979"(protein K11-linked ubiquitination)|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024990|interpro:IPR041221|mint:Q9H1A4|dip:DIP-32940N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:GCcoaN+24WplwiaqcHwHsjyWn789606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q07820 intact:EBI-6248094 intact:EBI-1003422|uniprotkb:Q9HD91|uniprotkb:Q9NRQ3|uniprotkb:Q9NRQ4|uniprotkb:Q9UHR7|uniprotkb:Q9UHR8|uniprotkb:Q9UHR9|uniprotkb:Q9UNJ1|uniprotkb:B2R6B2|uniprotkb:D3DV03|uniprotkb:D3DV04|ensembl:ENSP00000358022|ensembl:ENSP00000502859 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:mcl1_human(display_long)|uniprotkb:Bcl-2-related protein EAT/mcl1(gene name synonym)|uniprotkb:mcl1/EAT(gene name synonym)|uniprotkb:MCL1(gene name)|psi-mi:MCL1(display_short)|uniprotkb:BCL2L3(gene name synonym)|uniprotkb:Bcl-2-like protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001184249.1|refseq:NP_068779.1|refseq:NP_877495.1|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|ensembl:ENSG00000143384(gene)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|ensembl:ENST00000369026(transcript)|ensembl:ENST00000678770(transcript)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0001709"(cell fate determination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|go:"GO:0005741"(mitochondrial outer membrane)|interpro:IPR013281(Apoptosis regulator, Mcl-1)|go:"GO:0005829"(cytosol)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|rcsb pdb:6QFI|rcsb pdb:6QFM|rcsb pdb:6QFQ|interpro:IPR026298|interpro:IPR036834|rcsb pdb:6QGD|mint:Q07820|rcsb pdb:2KBW|rcsb pdb:2MHS|rcsb pdb:2NL9|rcsb pdb:2NLA|rcsb pdb:6QXJ|rcsb pdb:2PQK|rcsb pdb:6QYK|rcsb pdb:3D7V|rcsb pdb:6QYL|rcsb pdb:3IO9|rcsb pdb:6QYN|rcsb pdb:3KJ0|rcsb pdb:6QYO|rcsb pdb:3KJ1|rcsb pdb:3KJ2|rcsb pdb:6QYP|rcsb pdb:3KZ0|rcsb pdb:6QZ5|rcsb pdb:3MK8|rcsb pdb:3PK1|rcsb pdb:3TWU|rcsb pdb:3WIX|rcsb pdb:3WIY|rcsb pdb:6QZ6|rcsb pdb:4BPI|rcsb pdb:4BPJ|rcsb pdb:4HW2|rcsb pdb:4HW3|rcsb pdb:4HW4|rcsb pdb:4OQ5|rcsb pdb:4OQ6|rcsb pdb:4WGI|rcsb pdb:6QZ7|rcsb pdb:4WMR|rcsb pdb:4WMS|rcsb pdb:4WMT|rcsb pdb:4WMU|rcsb pdb:4WMV|rcsb pdb:4WMW|rcsb pdb:4WMX|rcsb pdb:4ZBF|rcsb pdb:4ZBI|rcsb pdb:5C3F|rcsb pdb:5C6H|rcsb pdb:5FC4|rcsb pdb:5FDO|rcsb pdb:5FDR|rcsb pdb:5IEZ|rcsb pdb:5IF4|rcsb pdb:6QZ8|rcsb pdb:5JSB|rcsb pdb:5KU9|rcsb pdb:5LOF|rcsb pdb:5MES|rcsb pdb:5MEV|rcsb pdb:5UUM|rcsb pdb:5VKC|rcsb pdb:5VX2|rcsb pdb:5W89|rcsb pdb:6QZB|rcsb pdb:5W8F|rcsb pdb:6B4L|rcsb pdb:6B4U|rcsb pdb:6STJ|rcsb pdb:6BW2|rcsb pdb:6BW8|rcsb pdb:6FS0|rcsb pdb:6FS1|rcsb pdb:6FS2|rcsb pdb:6MBD|rcsb pdb:6MBE|rcsb pdb:6NE5|rcsb pdb:6O4U|rcsb pdb:6O6F|rcsb pdb:6O6G|rcsb pdb:6OQB|rcsb pdb:6U63|rcsb pdb:6OQC|rcsb pdb:6U64|rcsb pdb:6U65|rcsb pdb:6OQD|rcsb pdb:6OQN|rcsb pdb:6OVC|rcsb pdb:6P3P|rcsb pdb:6QB3|rcsb pdb:6QB4|rcsb pdb:6QB6|rcsb pdb:6QFC|rcsb pdb:6U67|rcsb pdb:6U6F|rcsb pdb:6UA3|rcsb pdb:6UAB|rcsb pdb:6UD2|rcsb pdb:6UDI|rcsb pdb:6UDU|rcsb pdb:6UDV|rcsb pdb:6UDX|rcsb pdb:6UDY|rcsb pdb:6VBX|rcsb pdb:6YBG|rcsb pdb:6YBJ|rcsb pdb:6YBK|rcsb pdb:6YBL|rcsb pdb:6UDT|rcsb pdb:6ZIE|reactome:R-HSA-6785807|dip:DIP-231N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:zHymH4IKoOVjBLtkMF1dmNmH2DU9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8NFF5 intact:EBI-6248094 intact:EBI-742815|uniprotkb:Q8N5J1|uniprotkb:Q8N686|uniprotkb:Q8WU93|uniprotkb:Q8WUJ4|uniprotkb:Q96CR8|uniprotkb:Q99764|uniprotkb:Q9HBN6|ensembl:ENSP00000292180 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:fad1_human(display_long)|uniprotkb:FMN adenylyltransferase(gene name synonym)|uniprotkb:FAD pyrophosphorylase(gene name synonym)|uniprotkb:Flavin adenine dinucleotide synthase(gene name synonym)|uniprotkb:FLAD1(gene name)|psi-mi:FLAD1(display_short)|uniprotkb:PP591(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001171820.1|refseq:NP_001171821.1|refseq:NP_079483.3|refseq:NP_958800.1|ensembl:ENSG00000160688(gene)|ensembl:ENST00000292180(transcript)|go:"GO:0003919"(FMN adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006747"(FAD biosynthetic process)|go:"GO:0006771"(riboflavin metabolic process)|go:"GO:0042802"(identical protein binding)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR002500(Phosphoadenosine phosphosulphate reductase)|interpro:IPR012183(FAD synthetase, molybdopterin binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036425|mint:Q8NFF5|reactome:R-HSA-196843 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:XIktrF0PkC+W6/1cHF4l/WWtGUs9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q12948 intact:EBI-6248094 intact:EBI-1175253|uniprotkb:Q86UP7|uniprotkb:Q9BYM1|uniprotkb:Q9NUE5|uniprotkb:Q9UDD0|uniprotkb:Q9UP06|ensembl:ENSP00000493906 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:foxc1_human(display_long)|uniprotkb:Forkhead-related protein FKHL7(gene name synonym)|uniprotkb:Forkhead-related transcription factor 3(gene name synonym)|uniprotkb:FOXC1(gene name)|psi-mi:FOXC1(display_short)|uniprotkb:FKHL7(gene name synonym)|uniprotkb:FREAC3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENST00000645831(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001654"(eye development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|ensembl:ENSG00000054598(gene)|go:"GO:0001822"(kidney development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021549"(cerebellum development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0008301"(DNA binding, bending)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0060038"(cardiac muscle cell proliferation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR033067|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR036388|interpro:IPR036390|mint:Q12948|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072010"(glomerular epithelium development)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902038"(positive regulation of hematopoietic stem cell differentiation)|go:"GO:1902257"(negative regulation of apoptotic process involved in outflow tract morphogenesis)|go:"GO:1904798"(positive regulation of core promoter binding)|ensembl:ENSP00000493906|refseq:NP_001444.2 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+HuKwX8xMx86iCQW/a+vy/rWP389606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NRF9 intact:EBI-6248094 intact:EBI-744901|uniprotkb:Q5W0U1|uniprotkb:Q8N758|uniprotkb:Q8NCE5|uniprotkb:Q9NR32|ensembl:ENSP00000363284|ensembl:ENSP00000363286 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe3_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p17(gene name synonym)|uniprotkb:Chromatin accessibility complex 17 kDa protein(gene name synonym)|uniprotkb:Arsenic-transactivated protein(gene name synonym)|uniprotkb:POLE3(gene name)|psi-mi:POLE3(display_short)|uniprotkb:CHRAC17(gene name synonym)|uniprotkb:DNA polymerase II subunit 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001265184.1|refseq:NP_059139.3|ensembl:ENSG00000148229(gene)|ensembl:ENST00000374169(transcript)|ensembl:ENST00000374171(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:eTI1XsrypxKqml09tm4GAImoZgI9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P60228 intact:EBI-6248094 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UBQ5 intact:EBI-6248094 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99613 intact:EBI-6248094 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8N163 intact:EBI-6248094 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P23526 intact:EBI-6248094 intact:EBI-1053240|uniprotkb:Q96A36|ensembl:ENSP00000217426|uniprotkb:B3KUN3|uniprotkb:F5H737|uniprotkb:A8K307|uniprotkb:E1P5P2 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:sahh_human(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:AHCY(gene name)|psi-mi:AHCY(display_short)|uniprotkb:SAHH(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_000678.1|refseq:NP_001155238.1|ensembl:ENSG00000101444(gene)|ensembl:ENST00000217426(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0051287"(NAD binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P23526|rcsb pdb:1A7A|rcsb pdb:1LI4|refseq:XP_011526961.1|refseq:XP_005260374.1|refseq:NP_001309013.1|refseq:NP_001309014.1|rcsb pdb:3NJ4|rcsb pdb:4PFJ|rcsb pdb:4PGF|rcsb pdb:4YVF|rcsb pdb:5W49|rcsb pdb:5W4B|reactome:R-HSA-156581|reactome:R-HSA-1614635|reactome:R-HSA-2408508|reactome:R-HSA-5578997|refseq:XP_016883197.1|refseq:XP_016883198.1|dip:DIP-50557N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+y7rwgw9EIMaVrkt4/9kbZM44sg9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UMS0 intact:EBI-6248094 intact:EBI-725252|uniprotkb:Q53QE5|uniprotkb:Q6VNZ8|uniprotkb:Q7Z5B1|uniprotkb:Q7Z5B2|uniprotkb:Q9Y322|uniprotkb:B4DUL9|ensembl:ENSP00000387219 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:nfu1_human(display_long)|uniprotkb:HIRA-interacting protein 5(gene name synonym)|uniprotkb:NFU1(gene name)|psi-mi:NFU1(display_short)|uniprotkb:CGI-33(orf name)|uniprotkb:HIRIP5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001002755.1|refseq:NP_056515.2|refseq:NP_001002756.1|ensembl:ENSG00000169599(gene)|ensembl:ENST00000410022(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001075(NIF system FeS cluster assembly, NifU, C-terminal)|interpro:IPR014824(NIF system FeS cluster assembly, NifU-like scaffold, N-terminal)|interpro:IPR034904|interpro:IPR036498|rcsb pdb:2LTM|rcsb pdb:2M5O|refseq:XP_016859297.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ilyUYSw8tpfn8DDWGsj96O6f7jk9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O94916 intact:EBI-6248094 intact:EBI-308320|uniprotkb:O95693|uniprotkb:Q9UN18|uniprotkb:A6H8V5|uniprotkb:Q7LA65|intact:EBI-28988713|ensembl:ENSP00000346420|uniprotkb:A2RRB4|uniprotkb:E9PHR7|uniprotkb:Q969Q8|uniprotkb:Q96QH3 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:nfat5_human(display_long)|uniprotkb:NFAT5(gene name)|psi-mi:NFAT5(display_short)|uniprotkb:KIAA0827(gene name synonym)|uniprotkb:TONEBP(gene name synonym)|uniprotkb:T-cell transcription factor NFAT5(gene name synonym)|uniprotkb:Tonicity-responsive enhancer-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000102908(gene)|ensembl:ENST00000354436(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007588"(excretion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015646(Nuclear factor of activated T-cells 5)|interpro:IPR032397|interpro:IPR037059|rcsb pdb:1IMH|refseq:NP_006590.1|refseq:NP_619728.2|refseq:NP_775321.1|refseq:NP_775322.1|refseq:XP_011521120.1|refseq:NP_001106649.1|refseq:NP_619727.2|ensembl:ENSP00000338806|ensembl:ENSP00000346420|ensembl:ENST00000426654|ensembl:ENSP00000413126|ensembl:ENST00000567239|ensembl:ENSP00000457593|ensembl:ENST00000349945|refseq:XP_006721188.1|refseq:XP_016878359.1|dip:DIP-58524N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:MC0Zogrwtr9P0h5DBogMweJsHCE9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q5T4S7 intact:EBI-6248094 intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.74 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:8Iown8oj965YAir+95+3om5+1YM9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P49591 intact:EBI-6248094 intact:EBI-1053431|uniprotkb:Q5T5C8|uniprotkb:Q9NSE3|uniprotkb:B2R6Y9|ensembl:ENSP00000234677 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:sysc_human(display_long)|uniprotkb:SARS1(gene name)|psi-mi:SARS1(display_short)|uniprotkb:SARS(gene name synonym)|uniprotkb:SERS(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006504.2|ensembl:ENSG00000031698(gene)|ensembl:ENST00000234677(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019899"(enzyme binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:1904046"(negative regulation of vascular endothelial growth factor production)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR015866(Seryl-tRNA synthetase, class IIa, N-terminal)|interpro:IPR033729|interpro:IPR042103|rcsb pdb:3VBB|rcsb pdb:4L87|rcsb pdb:4RQE|rcsb pdb:4RQF|reactome:R-HSA-2408557|reactome:R-HSA-379716|dip:DIP-38215N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:4+Ai/MIybmiKJyfa0C0bhnW/CG49606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UHF7 intact:EBI-6248094 intact:EBI-2556151|uniprotkb:Q9UHH6|uniprotkb:Q9NWE1|uniprotkb:Q08AU2|uniprotkb:B4E1Z5|ensembl:ENSP00000220888|ensembl:ENSP00000492037 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:trps1_human(display_long)|uniprotkb:Tricho-rhino-phalangeal syndrome type I protein(gene name synonym)|uniprotkb:Zinc finger protein GC79(gene name synonym)|uniprotkb:TRPS1(gene name)|psi-mi:TRPS1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_054831.2|refseq:NP_001269831.1|refseq:XP_011515566.1|refseq:XP_011515568.1|refseq:XP_011515570.1|refseq:NP_001269832.1|refseq:XP_006716688.1|refseq:NP_001317528.1|ensembl:ENSG00000104447(gene)|ensembl:ENST00000220888(transcript)|ensembl:ENST00000640765(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR028440|interpro:IPR036236 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:M9Qu8GLaQiBGt4rWs+NuYJas8fs9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P58107 intact:EBI-6248094 intact:EBI-297954|uniprotkb:Q76E58|ensembl:ENSP00000484472|uniprotkb:A0A087X1U6|uniprotkb:Q9NSU9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:epipl_human(display_long)|uniprotkb:EPPK1(gene name)|psi-mi:EPPK1(display_short)|uniprotkb:EPIPL(gene name synonym)|uniprotkb:450 kDa epidermal antigen(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000484472|ensembl:ENSG00000261150(gene)|ensembl:ENST00000615648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042995"(cell projection)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0071944"(cell periphery)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1905041"(regulation of epithelium regeneration)|go:"GO:1990254"(keratin filament binding)|interpro:IPR001101(Plectin repeat)|interpro:IPR035915|interpro:IPR043197|refseq:NP_112598.3|refseq:XP_016869379.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:5ThrRQj4JeRG4xjZxMgueWUrjuA9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H4L5 intact:EBI-6248094 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9BZF3 intact:EBI-6248094 intact:EBI-2372709|uniprotkb:B4DTW1|uniprotkb:Q4ZG68|uniprotkb:Q53T68|uniprotkb:Q59H61|uniprotkb:Q7Z4Q1|uniprotkb:Q8N9T0|uniprotkb:Q96SR1|uniprotkb:C4AME4|uniprotkb:C4AMC0|uniprotkb:D3DPF6|uniprotkb:D3DPF7|uniprotkb:Q86V84|intact:EBI-28980578|ensembl:ENSP00000190611 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl6_human(display_long)|uniprotkb:OSBPL6(gene name)|psi-mi:OSBPL6(display_short)|uniprotkb:ORP6(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001188409.1|refseq:NP_001188410.1|refseq:NP_001188411.1|refseq:NP_115912.1|refseq:NP_665682.1|ensembl:ENSP00000190611|ensembl:ENST00000315022|ensembl:ENSP00000318723|ensembl:ENST00000357080|ensembl:ENSP00000349591|ensembl:ENST00000359685|ensembl:ENSP00000352713|ensembl:ENST00000392505|ensembl:ENSP00000376293|ensembl:ENST00000409045|ensembl:ENSP00000387248|ensembl:ENST00000409631|ensembl:ENSP00000386885|refseq:XP_016858755.1|refseq:XP_016858756.1|refseq:XP_016858759.1|refseq:XP_016858760.1|ensembl:ENSG00000079156(gene)|ensembl:ENST00000190611(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9BZF3|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:fOUP23b3kO1lBSBPNHP6Ghe6i8c9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O60232 intact:EBI-6248094 intact:EBI-741415|ensembl:ENSP00000312318 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:znrd2_human(display_long)|uniprotkb:ZNRD2(gene name)|psi-mi:ZNRD2(display_short)|uniprotkb:Autoantigen p27(gene name synonym)|uniprotkb:SSSCA1(gene name synonym)|uniprotkb:Sjoegren syndrome/scleroderma autoantigen 1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006387.1|ensembl:ENSG00000173465(gene)|ensembl:ENST00000309328(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0051301"(cell division)|interpro:IPR009563(Sjogrens syndrome scleroderma autoantigen 1)|rcsb pdb:6HCZ psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Uou80pZneoL39/0YYzb1TAbiB2I9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O95714 intact:EBI-6248094 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P61758 intact:EBI-6248094 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TB72 intact:EBI-6248094 intact:EBI-311190|uniprotkb:O00234|uniprotkb:Q53TV7|uniprotkb:Q8WY43|uniprotkb:Q9HAN2|uniprotkb:B4E2B6|uniprotkb:B3KSL0|uniprotkb:D6W527 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:pum2_human(display_long)|uniprotkb:PUM2(gene name)|psi-mi:PUM2(display_short)|uniprotkb:KIAA0235(gene name synonym)|uniprotkb:PUMH2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056132.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR001313(Pumilio RNA-binding region)|rcsb pdb:3Q0Q|rcsb pdb:3Q0R|rcsb pdb:3Q0S|refseq:NP_001269681.1|interpro:IPR033133|refseq:XP_011531021.1|refseq:XP_011531022.1|refseq:XP_011531023.1|refseq:XP_005262664.1|refseq:XP_005262666.1|refseq:XP_006712036.1|refseq:XP_006712037.1|interpro:IPR033712|refseq:XP_016859190.1|refseq:XP_016859191.1|refseq:XP_016859196.1|refseq:XP_016859197.1|reactome:R-HSA-8951664|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0051983"(regulation of chromosome segregation) psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:WOut5XivMQAQkHVKu1wjFTK6ePM9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TCU4 intact:EBI-6248094 intact:EBI-308651|uniprotkb:Q53S05|uniprotkb:Q580Q8|uniprotkb:Q86VP9|uniprotkb:Q9Y4G4|ensembl:ENSP00000482968|uniprotkb:A0A087WZY3 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:alms1_human(display_long)|uniprotkb:ALMS1(gene name)|psi-mi:ALMS1(display_short)|uniprotkb:KIAA0328(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000116127(gene)|ensembl:ENST00000613296(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0008017"(microtubule binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR028781|interpro:IPR029299|interpro:IPR040972|mint:Q8TCU4|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_055935.4 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:e91Hcs947kpQHPVhWAJRtYegdPg9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O00303 intact:EBI-6248094 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P55884 intact:EBI-6248094 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UKK3 intact:EBI-6248094 intact:EBI-2623021|uniprotkb:Q5QNZ9|uniprotkb:O75903|uniprotkb:Q14682|uniprotkb:Q9H1M6|ensembl:ENSP00000371419 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:parp4_human(display_long)|uniprotkb:ADPRTL1(gene name synonym)|uniprotkb:KIAA0177(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:193 kDa vault protein(gene name synonym)|uniprotkb:PARP-related/IalphaI-related H5/proline-rich(gene name synonym)|uniprotkb:"Vault poly(ADP-ribose) polymerase"(gene name synonym)|uniprotkb:PARP4(gene name)|psi-mi:PARP4(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 4(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:XP_011533234.1|refseq:NP_006428.2|ensembl:ENSG00000102699(gene)|ensembl:ENST00000381989(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006281"(DNA repair)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0042493"|go:"GO:0051972"(regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001357(BRCT)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR031273|interpro:IPR036420|interpro:IPR036465|interpro:IPR036616|mint:Q9UKK3|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:d1n+oei4ZSmqUnvJzMe6RLq2XOc9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O15371 intact:EBI-6248094 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UGP4 intact:EBI-6248094 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q02790 intact:EBI-6248094 intact:EBI-1047444|uniprotkb:D3DUQ1|uniprotkb:Q9UCP1|uniprotkb:Q9UCV7|ensembl:ENSP00000001008 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:fkbp4_human(display_long)|uniprotkb:FK506-binding protein 4(gene name synonym)|uniprotkb:HSP-binding immunophilin(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:52 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBP59(gene name synonym)|uniprotkb:Immunophilin FKBP52(gene name synonym)|uniprotkb:FKBP4(gene name)|psi-mi:FKBP4(display_short)|uniprotkb:FKBP52(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:59 kDa immunophilin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_002005.1|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR031212|mint:Q02790|rcsb pdb:1N1A|rcsb pdb:1P5Q|rcsb pdb:1Q1C|rcsb pdb:1QZ2|rcsb pdb:4DRJ|rcsb pdb:4LAV|rcsb pdb:4LAW|rcsb pdb:4LAX|rcsb pdb:4LAY|rcsb pdb:4TW8|go:"GO:0032991"(protein-containing complex)|rcsb pdb:6RCY|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061077"(chaperone-mediated protein folding)|ensembl:ENST00000001008(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|ensembl:ENSG00000004478(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0006825"(copper ion transport)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031111"(negative regulation of microtubule polymerization or depolymerization)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0032767"(copper-dependent protein binding)|dip:DIP-50866N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:N0vDRDgcQ2x8xiWKdX9Zt+cHcsQ9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9Y262 intact:EBI-6248094 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NZN5 intact:EBI-6248094 intact:EBI-821440|uniprotkb:O15086|uniprotkb:Q6P526|ensembl:ENSP00000380942 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:arhgc_human(display_long)|uniprotkb:Leukemia-associated RhoGEF(gene name synonym)|uniprotkb:ARHGEF12(gene name)|psi-mi:ARHGEF12(display_short)|uniprotkb:KIAA0382(gene name synonym)|uniprotkb:LARG(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001185594.1|refseq:NP_056128.1|refseq:NP_001288013.1|refseq:XP_011541022.1|refseq:XP_016872910.1|ensembl:ENST00000356641|ensembl:ENSP00000349056|ensembl:ENSP00000380942|dip:DIP-37887N|ensembl:ENSG00000196914(gene)|ensembl:ENST00000397843(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036305|interpro:IPR037801|interpro:IPR037884|interpro:IPR041020|rcsb pdb:1TXD|rcsb pdb:1X86|rcsb pdb:2OMJ|rcsb pdb:2OS6|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:lAnj6rTvOnWPt6fcTzMm8G1klKY9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q07864 intact:EBI-6248094 intact:EBI-348526|uniprotkb:Q13533|intact:EBI-28987244|ensembl:ENSP00000322570|uniprotkb:Q86VH9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe1_human(display_long)|uniprotkb:POLE(gene name)|psi-mi:POLE(display_short)|uniprotkb:POLE1(gene name synonym)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6175888|imex:IM-17346-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006222.2|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0048568"(embryonic organ development)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:5VBN|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962|go:"GO:0008270"(zinc ion binding)|ensembl:ENSG00000177084(gene)|ensembl:ENST00000320574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|ensembl:ENSP00000322570|dip:DIP-24243N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2019/04/15 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:oPDFCAO2AeDB4UjbeBvo8DPi+ow9606 intact-crc:D1EC4AD7FB0CF618|rigid:6L/Voyal9svUKaegkKwAoOYgrt8 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q86XZ4 intact:EBI-6164309 intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9HD23 intact:EBI-6164309 intact:EBI-6164303|ensembl:ENSP00000367637|uniprotkb:B4DQL2|uniprotkb:A8K4U3|uniprotkb:B3KNN2|uniprotkb:Q5T3Y1|uniprotkb:Q6NTG4|uniprotkb:Q96KF8|uniprotkb:Q9BVP1 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:mrs2_human(display_long)|uniprotkb:MRS2(gene name)|psi-mi:MRS2(display_short)|uniprotkb:HPT(gene name synonym)|uniprotkb:MRS2-like protein(gene name synonym)|uniprotkb:MRS2L(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000124532(gene)|ensembl:ENST00000378386(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045016"(mitochondrial magnesium ion transmembrane transport)|go:"GO:0055085"(transmembrane transport)|interpro:IPR039204|reactome:R-HSA-5223345|refseq:NP_001273193.1|refseq:NP_001273194.1|refseq:NP_001273195.1|refseq:NP_065713.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:qvKwgSW3lcwro4mQsW0ex2yN6IM9606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q96BP2 intact:EBI-6164309 intact:EBI-5454898|ensembl:ENSP00000361923 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:chch1_human(display_long)|uniprotkb:CHCHD1(gene name)|psi-mi:CHCHD1(display_short)|uniprotkb:C10orf34(gene name synonym)|uniprotkb:Nuclear protein C2360(gene name synonym)|uniprotkb:28S ribosomal protein S37, mitochondrial(gene name synonym)|uniprotkb:MRPS37(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS37(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_976043.1|ensembl:ENSG00000172586(gene)|ensembl:ENST00000372833(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR009069(MTCP1)|interpro:IPR010625(CHCH)|interpro:IPR033620|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:NrXh0XQ/wnElrxTM/KjipjA6WYY9606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q7Z7H5 intact:EBI-6164309 intact:EBI-2561449|uniprotkb:Q8N2P6|uniprotkb:A4D2K8|uniprotkb:Q7Z432|uniprotkb:B4DFJ4|uniprotkb:Q56VW3|ensembl:ENSP00000404042 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmed4_human(display_long)|uniprotkb:TMED4(gene name)|psi-mi:TMED4(display_short)|uniprotkb:ERS25(gene name synonym)|uniprotkb:Endoplasmic reticulum stress-response protein 25(gene name synonym)|uniprotkb:Putative NF-kappa-B-activating protein 156(gene name synonym)|uniprotkb:GMP25iso(gene name synonym)|uniprotkb:p24 family protein alpha-3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_872353.2|refseq:NP_001289987.1|refseq:NP_001289989.1|ensembl:ENSG00000158604(gene)|ensembl:ENST00000457408(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related) psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:SQNdxIm/WnTmBCD0BS0YjAny6R89606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9BVK6 intact:EBI-6164309 intact:EBI-1056827|uniprotkb:Q8WZ61|uniprotkb:Q14437|ensembl:ENSP00000330945 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmed9_human(display_long)|uniprotkb:TMED9(gene name)|psi-mi:TMED9(display_short)|uniprotkb:GP25L2(gene name synonym)|uniprotkb:Glycoprotein 25L2(gene name synonym)|uniprotkb:p25(gene name synonym)|uniprotkb:p24 family protein alpha-2(gene name synonym)|uniprotkb:GMP25(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_059980.2|ensembl:ENSG00000184840(gene)|ensembl:ENST00000332598(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:Q9BVK6|reactome:R-HSA-6807878|reactome:R-HSA-6811434 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:z5YDyY6mtnc4WGWU9G9sNgp+Ga09606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q04837 intact:EBI-6164309 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201 psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:P49755 intact:EBI-6164309 intact:EBI-998422|uniprotkb:Q15602|uniprotkb:Q16536|uniprotkb:Q86TC2|uniprotkb:Q86TS5|uniprotkb:B2R605|intact:EBI-1058680|ensembl:ENSP00000303145 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmeda_human(display_long)|uniprotkb:21 kDa transmembrane-trafficking protein(gene name synonym)|uniprotkb:Transmembrane protein Tmp21(gene name synonym)|uniprotkb:Tmp-21-I(gene name synonym)|uniprotkb:p24delta(gene name synonym)|uniprotkb:S31III125(gene name synonym)|uniprotkb:TMED10(gene name)|psi-mi:TMED10(display_short)|uniprotkb:TMP21(gene name synonym)|uniprotkb:p23(gene name synonym)|uniprotkb:p24 family protein delta-1(gene name synonym)|uniprotkb:S31I125(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 go:"GO:0007030"(Golgi organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0035964"(COPI-coated vesicle budding)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043279"(response to alkaloid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0048199"(vesicle targeting, to, from or within Golgi)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0106272"(protein localization to ERGIC)|go:"GO:0106273"(cytosol to ERGIC protein transport)|go:"GO:1902003"(regulation of amyloid-beta formation)|go:"GO:1902960"(negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|mint:P49755|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|reactome:R-HSA-6811434|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|ensembl:ENSG00000170348(gene)|ensembl:ENST00000303575(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001822"(kidney development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|refseq:NP_006818.3 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:Sj4B0x1qf0VJmI1aDFaw2/PiTxM9606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q13123 intact:EBI-6164309 intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9Y6G3 intact:EBI-6164309 intact:EBI-713615|uniprotkb:Q96Q48|ensembl:ENSP00000447547|ensembl:ENSP00000449392|ensembl:ENSP00000449884|uniprotkb:Q9P0S1|uniprotkb:Q6FID1 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:rm42_human(display_long)|uniprotkb:MRPL31(gene name synonym)|uniprotkb:MRPL42(gene name)|psi-mi:MRPL42(display_short)|uniprotkb:MRPS32(gene name synonym)|uniprotkb:RPML31(gene name synonym)|uniprotkb:39S ribosomal protein L31, mitochondrial(gene name synonym)|uniprotkb:HSPC204(orf name)|uniprotkb:PTD007(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL42(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_054769.1|refseq:NP_751917.1|ensembl:ENSG00000198015(gene)|ensembl:ENST00000549561(transcript)|ensembl:ENST00000549982(transcript)|ensembl:ENST00000552217(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|interpro:IPR019346|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:Y831BAUiZ3vI12KTXxRvGavXfmg9606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q15363 intact:EBI-6164309 intact:EBI-998485|ensembl:ENSP00000262225 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:tmed2_human(display_long)|uniprotkb:TMED2(gene name)|psi-mi:TMED2(display_short)|uniprotkb:RNP24(gene name synonym)|uniprotkb:Membrane protein p24A(gene name synonym)|uniprotkb:p24 family protein beta-1(gene name synonym)|uniprotkb:p24(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176017|imex:IM-17346-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000086598(gene)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001843"(neural tube closure)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030137"(COPI-coated vesicle)|ensembl:ENST00000262225(transcript)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048205"(COPI coating of Golgi vesicle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060717"(chorion development)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:1905069"(allantois development)|go:"GO:2000638"(regulation of SREBP signaling pathway)|interpro:IPR009038(GOLD)|interpro:IPR015720(TMP21 related)|interpro:IPR036598|rcsb pdb:5AZW|reactome:R-HSA-1912420|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-6807878|refseq:NP_001308374.1|reactome:R-HSA-6811434|refseq:NP_006806.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.74 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:TKdrbEIvtqutTXM3C6UcmMQU0eQ9606 intact-crc:2D652239286AD954|rigid:a72cLbRAyTfoGHSSW+EykWDk9qs false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12497-PRO_0000042399 uniprotkb:P62993 intact:EBI-6179753 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:p12497-pro_0000042399(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176061|imex:IM-17346-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1026248(chain-parent) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N psi-mi:"MI:0096"(pull down) chain-seq-start:588|chain-seq-end:1147|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Klpids91/HYZGIB9q9E28gVETBU11698 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:34FC50A433AD6EE2|rigid:5Pekgj/6WZGQS/y894I2L/J4+lo false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12497-PRO_0000042399 uniprotkb:Q69YN4 intact:EBI-6179753 intact:EBI-2819293|uniprotkb:Q9BTH4|uniprotkb:Q8IXH4|uniprotkb:Q6AHX9|uniprotkb:Q6NT78|uniprotkb:Q9UFW1|uniprotkb:Q9NWR3|uniprotkb:Q9P2B8|uniprotkb:Q9H9C9|uniprotkb:Q2M1N0|uniprotkb:Q7Z6C7|ensembl:ENSP00000297591 psi-mi:p12497-pro_0000042399(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:vir_human(display_long)|uniprotkb:VIRMA(gene name)|psi-mi:VIRMA(display_short)|uniprotkb:KIAA1429(gene name synonym)|uniprotkb:MSTP054(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176061|imex:IM-17346-32 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1026248(chain-parent) refseq:NP_056311.2|refseq:NP_892121.1|ensembl:ENSG00000164944(gene)|ensembl:ENST00000297591(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0080009"(mRNA methylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026736|interpro:IPR031801|mint:Q69YN4 psi-mi:"MI:0096"(pull down) chain-seq-start:588|chain-seq-end:1147|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:Klpids91/HYZGIB9q9E28gVETBU11698 rogid:JXKhohRVBiT4P++8+/edtkir+h89606 intact-crc:34FC50A433AD6EE2|rigid:5Pekgj/6WZGQS/y894I2L/J4+lo false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q8NAF0 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-6164383|intact:EBI-28978763|ensembl:ENSP00000320188 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:zn579_human(display_long)|uniprotkb:ZNF579(gene name)|psi-mi:ZNF579(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSG00000218891(gene)|ensembl:ENST00000325421(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSP00000320188|refseq:NP_689813.2 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uJ613Jxktit2lNClmAFV78Cz1XM9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P35556 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-6164392|ensembl:ENSP00000424571|ensembl:ENSP00000262464|uniprotkb:B4DU01|uniprotkb:Q59ES6 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:fbn2_human(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35556|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|interpro:IPR018097|ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR017878|refseq:NP_001990.2 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O15355 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O60563 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q96EB6 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O43865 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P51784 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9C0C9 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2339946|uniprotkb:Q8N425|uniprotkb:Q9H9B2|uniprotkb:Q6PIZ2|uniprotkb:Q9H7E4|uniprotkb:Q8TBN1|uniprotkb:A6NDU5|uniprotkb:Q9BSW1|uniprotkb:Q69YP4|uniprotkb:Q86UA4|uniprotkb:Q9H6E6|ensembl:ENSP00000323687 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ube2o_human(display_long)|uniprotkb:UBE2O(gene name)|psi-mi:UBE2O(display_short)|uniprotkb:KIAA1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_071349.3|ensembl:ENSG00000175931(gene)|ensembl:ENST00000319380(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9C0C9|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:FftBetvip/qFQAsQxmxRnGy8ctA9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q03111 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1384215|uniprotkb:Q14768|ensembl:ENSP00000252674 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:enl_human(display_long)|uniprotkb:MLLT1(gene name)|psi-mi:MLLT1(display_short)|uniprotkb:ENL(gene name synonym)|uniprotkb:LTG19(gene name synonym)|uniprotkb:YEATS1(gene name synonym)|uniprotkb:YEATS domain-containing protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_005925.2|ensembl:ENSG00000130382(gene)|ensembl:ENST00000252674(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008023"(transcription elongation factor complex)|interpro:IPR005033(YEATS)|interpro:IPR038704|interpro:IPR040930|rcsb pdb:5J9S|rcsb pdb:6HPW|rcsb pdb:6HPX|rcsb pdb:6HPY|rcsb pdb:6HPZ|rcsb pdb:6HQ0|rcsb pdb:6HT0|rcsb pdb:6HT1|rcsb pdb:6T1I|rcsb pdb:6T1J|rcsb pdb:6T1L|rcsb pdb:6T1M|rcsb pdb:6T1N|rcsb pdb:6T1O|rcsb pdb:7B0T|rcsb pdb:7B10|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:H+j5XCIlsBwjsia+gMfTFKev3mA9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UK99 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2509901|uniprotkb:B3KY16|uniprotkb:D3DR05|uniprotkb:Q9H0V2|uniprotkb:Q86X90|uniprotkb:Q9NUX2|ensembl:ENSP00000265651 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:fbx3_human(display_long)|uniprotkb:FBXO3(gene name)|psi-mi:FBXO3(display_short)|uniprotkb:FBX3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_036307.2|refseq:NP_208385.1|dip:DIP-53688N|ensembl:ENSG00000110429(gene)|ensembl:ENST00000265651(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007474(ApaG)|interpro:IPR018958|interpro:IPR028388|interpro:IPR036047|interpro:IPR036767|interpro:IPR037883|rcsb pdb:5HDW psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:zQB8ig3s51tXN81NtMrou84Rv6I9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P50750 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UHB7 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UQ35 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1050142|uniprotkb:A6NKB9|uniprotkb:Q9UHA8|uniprotkb:Q9UQ36|uniprotkb:Q9UQ37|uniprotkb:Q9UQ38|uniprotkb:Q9UQ40|uniprotkb:O15038|uniprotkb:O94803|uniprotkb:Q6NSL3|uniprotkb:Q6PIM3|uniprotkb:Q6PK40|uniprotkb:Q8IW17|uniprotkb:Q96GY7|uniprotkb:Q9P0G1|uniprotkb:D3DU97|ensembl:ENSP00000301740 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:srrm2_human(display_long)|uniprotkb:Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa(gene name synonym)|uniprotkb:Splicing coactivator subunit SRm300(gene name synonym)|uniprotkb:300 kDa nuclear matrix antigen(gene name synonym)|uniprotkb:SRRM2(gene name)|psi-mi:SRRM2(display_short)|uniprotkb:KIAA0324(gene name synonym)|uniprotkb:SRL300(gene name synonym)|uniprotkb:SRM300(gene name synonym)|uniprotkb:HSPC075(orf name)|uniprotkb:Tax-responsive enhancer element-binding protein 803(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_057417.3|ensembl:ENSG00000167978(gene)|ensembl:ENST00000301740(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q9UQ35|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7DVQ|reactome:R-HSA-72163 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:3yyPAOaCzKSCEg5guJSbq0MWrHI9606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q96JP5 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1052613|uniprotkb:Q86V47|uniprotkb:Q96JP4|uniprotkb:Q96QA3|uniprotkb:A6NHC4|uniprotkb:A8MSG7|ensembl:ENSP00000339030 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:zfp91_human(display_long)|uniprotkb:ZFP91(gene name)|psi-mi:ZFP91(display_short)|uniprotkb:FKSG11(orf name)|uniprotkb:ZNF757(gene name synonym)|uniprotkb:Zinc finger protein 757(gene name synonym)|uniprotkb:Zinc finger protein 91 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZFP91(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176082|imex:IM-17346-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001183980.1|refseq:NP_444251.1|ensembl:ENSG00000186660(gene)|ensembl:ENST00000316059(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q96JP5|rcsb pdb:2M9A|go:"GO:0004842"(ubiquitin-protein transferase activity) psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:oQuzxnamj/z05P/rG8EXnXTjzz89606 intact-crc:2DE9EFAAD2CCC121|rigid:Eigc3KuRK1lkVinCx6YkO4jU5GM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q7Z6Z7 intact:EBI-779991 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0096"(pull down) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15370 intact:EBI-779991 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N psi-mi:"MI:0096"(pull down) - author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13617 intact:EBI-779991 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:P46379 intact:EBI-779991 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15369 intact:EBI-779991 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0096"(pull down) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9C0C7 intact:EBI-779991 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q93034 intact:EBI-779991 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q99615 intact:EBI-779991 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q8IWV8 intact:EBI-779991 intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9ULX6 intact:EBI-779991 intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176135|imex:IM-17346-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606 intact-crc:158FB96CC506DF06|rigid:TF2KSORvjq9eELngFpHWUueesiM false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9NRK6 intact:EBI-6164519 intact:EBI-6164528|ensembl:ENSP00000355637|uniprotkb:Q13040|uniprotkb:Q6P1Q8|uniprotkb:Q9H3V0 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:abcba_human(display_long)|uniprotkb:ABC-mitochondrial erythroid protein(gene name synonym)|uniprotkb:ABCB10(gene name)|psi-mi:ABCB10(display_short)|uniprotkb:ATP-binding cassette transporter 10(gene name synonym)|uniprotkb:Mitochondrial ATP-binding cassette 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000135776(gene)|ensembl:ENST00000344517(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0070455"(positive regulation of heme biosynthetic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|go:"GO:0006783"(heme biosynthetic process)|interpro:IPR036640|interpro:IPR039421|rcsb pdb:3ZDQ|rcsb pdb:4AYT|rcsb pdb:4AYW|rcsb pdb:4AYX|reactome:R-HSA-1369007|interpro:IPR030260|refseq:NP_036221.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:XJOAh9Mv+ivD/9GzGjjkmvyvf9g9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y6C9 intact:EBI-6164519 intact:EBI-6164522|ensembl:ENSP00000303222|ensembl:ENSP00000495027|uniprotkb:B2R7L8 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:mtch2_human(display_long)|uniprotkb:MTCH2(gene name)|psi-mi:MTCH2(display_short)|uniprotkb:MIMP(gene name synonym)|uniprotkb:Met-induced mitochondrial protein(gene name synonym)|uniprotkb:HSPC032(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 interpro:IPR018108|interpro:IPR023395|mint:Q9Y6C9|go:"GO:0070585"(protein localization to mitochondrion)|ensembl:ENSG00000109919(gene)|ensembl:ENSG00000285121(gene)|ensembl:ENST00000302503(transcript)|ensembl:ENST00000643223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|refseq:NP_001304160.1|refseq:NP_001304161.1|refseq:NP_001304162.1|refseq:NP_055157.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:Lbg7MBRn09cRzoYOiSt4g4FjsjA9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q2PZI1 intact:EBI-6164519 intact:EBI-6164516|ensembl:ENSP00000308695|uniprotkb:O94954|uniprotkb:Q4G151 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:d19l1_human(display_long)|uniprotkb:Protein dpy-19 homolog 1(gene name synonym)|uniprotkb:DPY19L1(gene name)|psi-mi:DPY19L1(display_short)|uniprotkb:Dpy-19-like protein 1(gene name synonym)|uniprotkb:GA0500(gene name synonym)|uniprotkb:KIAA0877(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000173852(gene)|ensembl:ENST00000310974(transcript)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018406"(protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan)|interpro:IPR018732|interpro:IPR030041|go:"GO:0000030"(mannosyltransferase activity)|refseq:NP_056098.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:JnDZiz7UFIUQvuIps5neyIQulsY9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y6G9 intact:EBI-6164519 intact:EBI-2556107|uniprotkb:A2RRG7|uniprotkb:Q53HK7|uniprotkb:Q53HC8|ensembl:ENSP00000273130 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1l1_human(display_long)|uniprotkb:DNCLI1(gene name synonym)|uniprotkb:Dynein light intermediate chain 1, cytosolic(gene name synonym)|uniprotkb:Dynein light chain A(gene name synonym)|uniprotkb:DYNC1LI1(gene name)|psi-mi:DYNC1LI1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_057225.2|ensembl:ENSG00000144635(gene)|ensembl:ENST00000273130(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0051301"(cell division)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|mint:Q9Y6G9|rcsb pdb:6B9H|rcsb pdb:6PSD|rcsb pdb:6PSE|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0007018"(microtubule-based movement) psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:LxQSfBpzuf6Acus2jBy0s53FdhU9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O00217 intact:EBI-6164519 intact:EBI-1246309|uniprotkb:Q0VDA8|uniprotkb:B2RB86|ensembl:ENSP00000315774 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ndus8_human(display_long)|uniprotkb:NDUFS8(gene name)|psi-mi:NDUFS8(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 23 kDa subunit(gene name synonym)|uniprotkb:Complex I-23kD(gene name synonym)|uniprotkb:TYKY subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_002487.1|refseq:XP_011543355.1|refseq:XP_005274070.1|refseq:XP_005274071.1|ensembl:ENSG00000110717(gene)|ensembl:ENST00000313468(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009060"(aerobic respiration)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR010226(NADH-quinone oxidoreductase, chain I)|interpro:IPR017896|interpro:IPR017900|mint:O00217|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:VzxtzGTNMccCfBDeDy9LKDN5V289606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13409 intact:EBI-6164519 intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9H4A6 intact:EBI-6164519 intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1 psi-mi:"MI:0096"(pull down) - author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P43243 intact:EBI-6164519 intact:EBI-352602|ensembl:ENSP00000378284|ensembl:ENSP00000482895|uniprotkb:Q9UHW0|uniprotkb:Q9UQ27|uniprotkb:D3DQC3|uniprotkb:B7ZAV5 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:matr3_human(display_long)|uniprotkb:KIAA0723(gene name synonym)|uniprotkb:MATR3(gene name)|psi-mi:MATR3(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000015479(gene)|ensembl:ENST00000394805(transcript)|ensembl:ENST00000618441(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0035198"(miRNA binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034928|interpro:IPR034930|interpro:IPR035979|mint:P43243|refseq:NP_001181883.1|refseq:NP_001181884.1|refseq:NP_061322.2|refseq:NP_954659.1|refseq:NP_001181885.1|refseq:NP_001269207.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:3UZlyCZHgdr1SBgUctv9Ev7XBSQ9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q5SW79 intact:EBI-6164519 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P28288 intact:EBI-6164519 intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q14204 intact:EBI-6164519 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8IWZ3 intact:EBI-6164519 intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N psi-mi:"MI:0096"(pull down) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P21964 intact:EBI-6164519 intact:EBI-372265|uniprotkb:Q6IB07|uniprotkb:Q6ICE6|uniprotkb:A8MPV9|intact:EBI-743305|uniprotkb:Q9BWC7|intact:EBI-11576026|ensembl:ENSP00000354511|ensembl:ENSP00000384654|ensembl:ENSP00000385150|ensembl:ENSP00000385917|ensembl:ENSP00000503583|ensembl:ENSP00000503719|ensembl:ENSP00000504402 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:comt_human(display_long)|uniprotkb:COMT(gene name)|psi-mi:COMT(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_000745.1|refseq:NP_001128633.1|refseq:NP_001128634.1|refseq:NP_009294.1|refseq:XP_016884083.1|refseq:XP_016884084.1|ensembl:ENSG00000093010(gene)|ensembl:ENST00000361682(transcript)|ensembl:ENST00000403710(transcript)|ensembl:ENST00000406520(transcript)|ensembl:ENST00000407537(transcript)|ensembl:ENST00000676678(transcript)|ensembl:ENST00000678255(transcript)|ensembl:ENST00000678868(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007565"(female pregnancy)|go:"GO:0007612"(learning)|go:"GO:0007614"(short-term memory)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008210"(estrogen metabolic process)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016036"(cellular response to phosphate starvation)|go:"GO:0016206"(catechol O-methyltransferase activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032259"(methylation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032502"(developmental process)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042135"(neurotransmitter catabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042420"(dopamine catabolic process)|go:"GO:0042424"(catecholamine catabolic process)|go:"GO:0042493"|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043627"(response to estrogen)|go:"GO:0044297"(cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:0048265"(response to pain)|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050668"(positive regulation of homocysteine metabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0070062"(extracellular exosome)|go:"GO:0102084"(L-dopa O-methyltransferase activity)|go:"GO:0102938"(orcinol O-methyltransferase activity)|interpro:IPR002935(O-methyltransferase, family 3)|interpro:IPR017128(Catechol O-methyltransferase, eukaryotic)|interpro:IPR029063|mint:P21964|rcsb pdb:3A7E|rcsb pdb:3BWM|rcsb pdb:3BWY|rcsb pdb:4PYI|rcsb pdb:4PYJ|rcsb pdb:4PYK|rcsb pdb:4XUD|rcsb pdb:4XUE|rcsb pdb:5LSA|rcsb pdb:6I3C|rcsb pdb:6I3D|reactome:R-HSA-156581|reactome:R-HSA-379397|reactome:R-HSA-379398|reactome:R-HSA-9679191|rcsb pdb:4XUC psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:3Fnq8iVqPpOWNX6QQuiNRSsTFN09606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8TEB1 intact:EBI-6164519 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16531 intact:EBI-6164519 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q96A33 intact:EBI-6164519 intact:EBI-720151|uniprotkb:Q96D00|uniprotkb:Q96JZ7|uniprotkb:Q9H3E4|uniprotkb:Q9NRG3|uniprotkb:B2RAS8|uniprotkb:D3DU20|ensembl:ENSP00000225726|ensembl:ENSP00000384888 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ccd47_human(display_long)|uniprotkb:CCDC47(gene name)|psi-mi:CCDC47(display_short)|uniprotkb:Calumin(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 47(gene name synonym)|uniprotkb:GK001(orf name)|uniprotkb:MSTP041(orf name)|uniprotkb:PSEC0077(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_064583.2|ensembl:ENSG00000108588(gene)|ensembl:ENST00000225726(transcript)|ensembl:ENST00000403162(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006983"(ER overload response)|go:"GO:0009791"(post-embryonic development)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043022"(ribosome binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045048"(protein insertion into ER membrane)|interpro:IPR012879(Protein of unknown function DUF1682)|mint:Q96A33|rcsb pdb:6W6L|go:"GO:0030867"(rough endoplasmic reticulum membrane)|refseq:XP_005257584.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:DdZFzZrrc4culfYoex0Czf/X6SQ9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O00116 intact:EBI-6164519 intact:EBI-2838732|uniprotkb:A5D8U9|uniprotkb:Q2TU35|ensembl:ENSP00000264167 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:adas_human(display_long)|uniprotkb:AGPS(gene name)|psi-mi:AGPS(display_short)|uniprotkb:Aging-associated gene 5 protein(gene name synonym)|uniprotkb:Alkylglycerone-phosphate synthase(gene name synonym)|uniprotkb:AAG5(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003650.1|ensembl:ENSG00000018510(gene)|ensembl:ENST00000264167(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008609"(alkylglycerone-phosphate synthase activity)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0071949"(FAD binding)|interpro:IPR004113(FAD-linked oxidase, C-terminal)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016164(FAD-linked oxidase-like, C-terminal)|interpro:IPR016167(FAD-binding, type 2, subdomain 1)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR016171(Vanillyl-alcohol oxidase, C-terminal subdomain 2)|interpro:IPR025650|interpro:IPR036318|mint:O00116|reactome:R-HSA-75896|reactome:R-HSA-9033241|reactome:R-HSA-9033500|interpro:IPR016166(FAD-binding, type 2) psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:P8f6+j/f+WID0lFZnLIvVN5OSzM9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16576 intact:EBI-6164519 intact:EBI-352227|ensembl:ENSP00000369427|intact:EBI-3505029|uniprotkb:Q5JP00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:rbbp7_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:RBAP46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_002884.1|ensembl:ENST00000380087(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q16576|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:7M3X|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8951664|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|ensembl:ENSG00000102054(gene)|refseq:NP_001185648.1|dip:DIP-436N psi-mi:"MI:0096"(pull down) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9BW61 intact:EBI-6164519 intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y4B6 intact:EBI-6164519 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0096"(pull down) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q5T8D3 intact:EBI-6164519 intact:EBI-4279983|uniprotkb:B3KQ56|uniprotkb:D3DRW0|uniprotkb:Q5T8D4|uniprotkb:Q5T8E1|uniprotkb:Q5T8E2|uniprotkb:Q86UV1|uniprotkb:Q8N6E3|uniprotkb:Q9UFB5|ensembl:ENSP00000365049 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:acbd5_human(display_long)|uniprotkb:ACBD5(gene name)|psi-mi:ACBD5(display_short)|uniprotkb:KIAA1996(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001035938.1|refseq:NP_663736.2|refseq:NP_001288180.1|refseq:NP_001288181.1|refseq:NP_001288182.1|ensembl:ENSG00000107897(gene)|ensembl:ENST00000375888(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030242"(autophagy of peroxisome)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR016347(Membrane-associated diazepam binding inhibitor)|interpro:IPR022408|interpro:IPR035984|rcsb pdb:3FLV|reactome:R-HSA-390918|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798|refseq:XP_016872396.1|refseq:XP_016872397.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:o116xDV0fJe28E4BnL3ENXQxn1I9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q6ZPD9 intact:EBI-6164519 intact:EBI-2871931|uniprotkb:Q68DC7|uniprotkb:Q6ZTS2|uniprotkb:Q6ZTB7|ensembl:ENSP00000376081|ensembl:ENSP00000344937 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:d19l3_human(display_long)|uniprotkb:DPY19L3(gene name)|psi-mi:DPY19L3(display_short)|uniprotkb:Dpy-19-like protein 3(gene name synonym)|uniprotkb:Protein dpy-19 homolog 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:XP_011524828.1|refseq:NP_001166245.1|refseq:NP_997208.2|ensembl:ENST00000342179(transcript)|ensembl:ENST00000392250(transcript)|go:"GO:0000030"(mannosyltransferase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018406"(protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan)|interpro:IPR018732|interpro:IPR030039|ensembl:ENSG00000178904(gene) psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:N+hLBwy/nP3zdNXbr/GXW3V8AqI9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O14929 intact:EBI-6164519 intact:EBI-2339359|uniprotkb:Q53SU4|uniprotkb:Q53QF0|uniprotkb:Q49A44|uniprotkb:Q6P594|uniprotkb:Q8WWB9|ensembl:ENSP00000264108 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:hat1_human(display_long)|uniprotkb:HAT1(gene name)|psi-mi:HAT1(display_short)|uniprotkb:KAT1(gene name synonym)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176176|imex:IM-17346-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003633.1|dip:DIP-52811N|ensembl:ENSG00000128708(gene)|ensembl:ENST00000264108(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006323"(DNA packaging)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0007584"(response to nutrient)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|mint:O14929|rcsb pdb:2P0W|rcsb pdb:6VO5|reactome:R-HSA-3214847 psi-mi:"MI:0096"(pull down) - author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:80KgRaid3NeRfAUdTHMQ/r0VuGo9606 intact-crc:ADA4780A9985A29E|rigid:zZ1f4HdZMKr2MJzkz70eNUd7t2E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q86T03 intact:EBI-6248147 intact:EBI-6164623|uniprotkb:B2RA35|uniprotkb:Q86U09|uniprotkb:Q8WUC0|uniprotkb:Q9BU67|uniprotkb:Q9NSU8|ensembl:ENSP00000250489 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:pp4p1_human(display_long)|uniprotkb:PIP4P1(gene name)|psi-mi:PIP4P1(display_short)|uniprotkb:C14orf9(gene name synonym)|uniprotkb:PtdIns-4,5-P2 4-Ptase I(gene name synonym)|uniprotkb:TMEM55B(gene name synonym)|uniprotkb:Transmembrane protein 55B(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSP00000250489|ensembl:ENST00000398020|ensembl:ENSP00000381102|refseq:NP_001094284.1|refseq:NP_653169.2|ensembl:ENSG00000165782(gene)|ensembl:ENST00000250489(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0070070"(proton-transporting V-type ATPase complex assembly)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR019178|reactome:R-HSA-6811555|reactome:R-HSA-8847453 psi-mi:"MI:0096"(pull down) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nbc8AvBd7g6bpNjfhhK7aPZ0BYk9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q5T9A4 intact:EBI-6248147 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P42704 intact:EBI-6248147 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0096"(pull down) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P20020 intact:EBI-6248147 intact:EBI-5279998|uniprotkb:Q12992|uniprotkb:Q12993|uniprotkb:Q13819|uniprotkb:Q13820|uniprotkb:Q13821|uniprotkb:Q16504|uniprotkb:Q93082|ensembl:ENSP00000261173|ensembl:ENSP00000392043 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:at2b1_human(display_long)|uniprotkb:ATP2B1(gene name)|psi-mi:ATP2B1(display_short)|uniprotkb:PMCA1(gene name synonym)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:XP_011536709.1|refseq:NP_001001323.1|refseq:NP_001673.2|refseq:XP_016874847.1|reactome:R-HSA-9662360|ensembl:ENSG00000070961(gene)|ensembl:ENST00000261173(transcript)|ensembl:ENST00000428670(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0034220"(ion transmembrane transport)|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|mint:P20020|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|rcsb pdb:6A69|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303 psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:kCpUNLYDF38hciXj32D8rXbXULg9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9Y297 intact:EBI-6248147 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q16537 intact:EBI-6248147 intact:EBI-968374|uniprotkb:B7ZAW5|uniprotkb:J3KQN6|ensembl:ENSP00000337641|uniprotkb:Q52LW4|uniprotkb:A4FU37|uniprotkb:B7ZKK8|intact:EBI-10962508|uniprotkb:B7ZKK9 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:2a5e_human(display_long)|uniprotkb:PPP2R5E(gene name)|psi-mi:PPP2R5E(display_short)|uniprotkb:PP2A B subunit isoform B'-epsilon(gene name synonym)|uniprotkb:PP2A B subunit isoform B56-epsilon(gene name synonym)|uniprotkb:PP2A B subunit isoform PR61-epsilon(gene name synonym)|uniprotkb:PP2A B subunit isoform R5-epsilon(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000154001(gene)|ensembl:ENST00000337537(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0072542"(protein phosphatase activator activity)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR016024(Armadillo-type fold)|mint:Q16537|reactome:R-HSA-141444|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-9648025|interpro:IPR011989(Armadillo-like helical)|refseq:NP_006237.1|refseq:NP_001269108.1|refseq:NP_001269109.1|refseq:NP_001269110.1|refseq:NP_001269111.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:m6vjnzx9eg+HpXrI2KKBLPbObzA9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UKB1 intact:EBI-6248147 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N psi-mi:"MI:0096"(pull down) - author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P43487 intact:EBI-6248147 intact:EBI-1032909|uniprotkb:Q53EY3|ensembl:ENSP00000327583 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rang_human(display_long)|uniprotkb:RANBP1(gene name)|psi-mi:RANBP1(display_short)|uniprotkb:Ran-binding protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_002873.1|ensembl:ENSG00000099901(gene)|ensembl:ENST00000331821(transcript)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0046907"(intracellular transport)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1K5D|rcsb pdb:1K5G|reactome:R-HSA-165054|refseq:NP_001265568.1|refseq:NP_001265569.1|dip:DIP-35058N psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:OWndphaUCDSO3+MGhJqcuQo2Lk09606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q969Z0 intact:EBI-6248147 intact:EBI-702328|uniprotkb:O14710|uniprotkb:Q53GI8|uniprotkb:Q8NDM4|uniprotkb:Q9BUC6|uniprotkb:Q9Y2F6|uniprotkb:A4D2L2|uniprotkb:A4D2L3|uniprotkb:D3DVL5|uniprotkb:D3DVL6|ensembl:ENSP00000258770|ensembl:ENSP00000420597 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fakd4_human(display_long)|uniprotkb:Transforming growth factor beta regulator 4(gene name synonym)|uniprotkb:Cell cycle progression restoration protein 2(gene name synonym)|uniprotkb:TBRG4(gene name)|psi-mi:TBRG4(display_short)|uniprotkb:CPR2(gene name synonym)|uniprotkb:FASTKD4(gene name synonym)|uniprotkb:KIAA0948(gene name synonym)|uniprotkb:Protein TBRG4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_004740.2|refseq:NP_112162.1|refseq:NP_954573.1|ensembl:ENSG00000136270(gene)|ensembl:ENST00000258770(transcript)|ensembl:ENST00000494076(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090615"(mitochondrial mRNA processing)|interpro:IPR010622(FAST kinase leucine-rich)|interpro:IPR013579(FAST kinase-like protein, subdomain 2)|interpro:IPR013584(RAP domain)|mint:Q969Z0 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2maj6VmOPUpSw5F+xJG2kfNKAc49606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9GZT3 intact:EBI-6248147 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 psi-mi:"MI:0096"(pull down) - author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9C0E2 intact:EBI-6248147 intact:EBI-1044855|uniprotkb:Q5VUZ5|uniprotkb:Q9H934|uniprotkb:Q8N3V6|ensembl:ENSP00000255305 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:xpo4_human(display_long)|uniprotkb:XPO4(gene name)|psi-mi:XPO4(display_short)|uniprotkb:KIAA1721(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_071904.4|ensembl:ENSG00000132953(gene)|ensembl:ENST00000255305(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR044189|mint:Q9C0E2|go:"GO:0005643"(nuclear pore) psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:+7lQFg9CBnDLFt9rqjLb//HPJnQ9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9Y6D6 intact:EBI-6248147 intact:EBI-1044254|uniprotkb:Q9NV46|uniprotkb:Q9UFV2|uniprotkb:Q9UNL0|ensembl:ENSP00000262215 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:big1_human(display_long)|uniprotkb:ARFGEF1(gene name)|psi-mi:ARFGEF1(display_short)|uniprotkb:ARFGEP1(gene name synonym)|uniprotkb:BIG1(gene name synonym)|uniprotkb:p200 ARF-GEP1(gene name synonym)|uniprotkb:p200 ARF guanine nucleotide exchange factor(gene name synonym)|uniprotkb:ADP-ribosylation factor guanine nucleotide-exchange factor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000066777(gene)|ensembl:ENST00000262215(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0007030"(Golgi organization)|go:"GO:0010256"(endomembrane system organization)|go:"GO:0015031"(protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017022"(myosin binding)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090284"(positive regulation of protein glycosylation in Golgi)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR000904(SEC7-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032629|interpro:IPR032691|interpro:IPR035999|mint:Q9Y6D6|rcsb pdb:3LTL|rcsb pdb:5EE5|rcsb pdb:5J5C|go:"GO:0051897"(positive regulation of protein kinase B signaling)|refseq:NP_006412.2|refseq:XP_005251191.1|dip:DIP-29748N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:HIXdg7zEoEpHcC+KwTUjNFSgr5M9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q53GQ0 intact:EBI-6248147 intact:EBI-2963255|uniprotkb:Q96EA9|ensembl:ENSP00000278353|uniprotkb:A8K9B0|uniprotkb:Q9Y6G8|uniprotkb:Q96JU2|uniprotkb:D3DR23 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:dhb12_human(display_long)|uniprotkb:HSD17B12(gene name)|psi-mi:HSD17B12(display_short)|uniprotkb:17-beta-hydroxysteroid dehydrogenase 12(gene name synonym)|uniprotkb:3-ketoacyl-CoA reductase(gene name synonym)|uniprotkb:SDR12C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 12C member 1(gene name synonym)|uniprotkb:Estradiol 17-beta-dehydrogenase 12(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000149084(gene)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006703"(estrogen biosynthetic process)|go:"GO:0008201"(heparin binding)|go:"GO:0009923"(fatty acid elongase complex)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0044594"("17-beta-hydroxysteroid dehydrogenase (NAD+) activity")|go:"GO:0050062"(long-chain-fatty-acyl-CoA reductase activity)|go:"GO:0072582"("17-beta-hydroxysteroid dehydrogenase (NADP+) activity")|ensembl:ENST00000278353(transcript)|go:"GO:0102339"(3-oxo-arachidoyl-CoA reductase activity)|go:"GO:0102341"(3-oxo-lignoceroyl-CoA reductase activity)|go:"GO:0102342"(3-oxo-cerotoyl-CoA reductase activity)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|mint:Q53GQ0|reactome:R-HSA-193048|reactome:R-HSA-75876|go:"GO:0102340"(3-oxo-behenoyl-CoA reductase activity)|refseq:NP_057226.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2R2pFY0c9yRuCvLU2J8n2urR+0o9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UHQ9 intact:EBI-6248147 intact:EBI-953870|ensembl:ENSP00000356218|uniprotkb:A0PK21|uniprotkb:O95329|uniprotkb:Q53F73|uniprotkb:Q8NCL5|uniprotkb:Q9UHJ1|uniprotkb:B2R8E0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:nb5r1_human(display_long)|uniprotkb:"NAD(P)H:quinone oxidoreductase type 3 polypeptide A2"(gene name synonym)|uniprotkb:Humb5R2(gene name synonym)|uniprotkb:CYB5R1(gene name)|psi-mi:CYB5R1(display_short)|uniprotkb:NQO3A2(gene name synonym)|uniprotkb:UNQ3049/PRO9865(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000159348(gene)|ensembl:ENST00000367249(transcript)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071949"(FAD binding)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-HSA-114608|reactome:R-HSA-1237044|go:"GO:0016020"(membrane)|refseq:NP_057327.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:TOvJYSyfYu73Ac/SYjup+ABu74g9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UBB4 intact:EBI-6248147 intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P78357 intact:EBI-6248147 intact:EBI-1751903|ensembl:ENSP00000264638 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cntp1_human(display_long)|uniprotkb:CNTNAP1(gene name)|psi-mi:CNTNAP1(display_short)|uniprotkb:CASPR(gene name synonym)|uniprotkb:NRXN4(gene name synonym)|uniprotkb:Neurexin-4(gene name synonym)|uniprotkb:Neurexin IV(gene name synonym)|uniprotkb:p190(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003623.1|refseq:XP_016880727.1|ensembl:ENSG00000108797(gene)|ensembl:ENST00000264638(transcript)|go:"GO:0002175"(protein localization to paranode region of axon)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019227"(neuronal action potential propagation)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0033010"(paranodal junction)|go:"GO:0033270"(paranode region of axon)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0071205"(protein localization to juxtaparanode region of axon)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR028872|interpro:IPR036056|mint:P78357|reactome:R-HSA-447043 psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:ZNEoUJsmWmciH97yPBAegOqrO1E9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NQC3 intact:EBI-6248147 intact:EBI-715945|intact:EBI-1753019|uniprotkb:O94962|uniprotkb:Q9BXG5|uniprotkb:Q9H212|uniprotkb:Q9H3I3|uniprotkb:Q9UQ42|uniprotkb:Q9Y293|uniprotkb:Q9Y2Y7|uniprotkb:Q9Y5U6|intact:EBI-1958210|intact:EBI-1056082|uniprotkb:Q7L7Q8|uniprotkb:Q96B16|intact:EBI-28967519|ensembl:ENSP00000337838|uniprotkb:Q7L7Q5|uniprotkb:Q7L7Q6|uniprotkb:Q8IUA4 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn4_human(display_long)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000317610|ensembl:ENSP00000322147|ensembl:ENSP00000337838|ensembl:ENST00000357376|ensembl:ENSP00000349944|ensembl:ENST00000357732|ensembl:ENSP00000350365|ensembl:ENST00000394609|ensembl:ENSP00000378107|ensembl:ENST00000394611|ensembl:ENSP00000378109|ensembl:ENST00000404909|ensembl:ENSP00000385650|ensembl:ENST00000405240|ensembl:ENSP00000384471|refseq:NP_008939.1|refseq:NP_065393.1|refseq:NP_722550.1|refseq:NP_997403.1|refseq:NP_997404.1|ensembl:ENSG00000115310(gene)|ensembl:ENST00000337526(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q9NQC3|rcsb pdb:2G31|rcsb pdb:2JV5|reactome:R-HSA-193634|refseq:XP_005264491.1|refseq:NP_001308788.1|refseq:NP_001308789.1|refseq:NP_001308790.1|refseq:NP_001308791.1|refseq:NP_001308792.1|refseq:NP_001308833.1|refseq:XP_016860007.1|refseq:XP_016860008.1|dip:DIP-42003N psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:uhivTNOPdC7+q81CliY0Ozu0EwA9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P63208 intact:EBI-6248147 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P40939 intact:EBI-6248147 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P18859 intact:EBI-6248147 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NVI7 intact:EBI-6248147 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N psi-mi:"MI:0096"(pull down) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95197 intact:EBI-6248147 intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95573 intact:EBI-6248147 intact:EBI-1190822|uniprotkb:Q60I92|uniprotkb:Q8IUM9|ensembl:ENSP00000350012|ensembl:ENSP00000375918|ensembl:ENSP00000504861|ensembl:ENSP00000504907|ensembl:ENSP00000505400|ensembl:ENSP00000505654|ensembl:ENSP00000505793|ensembl:ENSP00000505856|ensembl:ENSP00000505940|ensembl:ENSP00000506361|ensembl:ENSP00000506468|intact:EBI-21359981 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:acsl3_human(display_long)|uniprotkb:Long-chain acyl-CoA synthetase 3(gene name synonym)|uniprotkb:ACSL3(gene name)|psi-mi:ACSL3(display_short)|uniprotkb:ACS3(gene name synonym)|uniprotkb:FACL3(gene name synonym)|uniprotkb:LACS3(gene name synonym)|uniprotkb:Arachidonate--CoA ligase(gene name synonym)|uniprotkb:Long-chain-fatty-acid--CoA ligase 3(gene name synonym)|uniprotkb:Medium-chain acyl-CoA ligase Acsl3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_004448.2|refseq:NP_976251.1|refseq:XP_016859073.1|ensembl:ENSG00000123983(gene)|ensembl:ENST00000357430(transcript)|ensembl:ENST00000392066(transcript)|ensembl:ENST00000679514(transcript)|ensembl:ENST00000679558(transcript)|ensembl:ENST00000680147(transcript)|ensembl:ENST00000680251(transcript)|ensembl:ENST00000680395(transcript)|ensembl:ENST00000680684(transcript)|ensembl:ENST00000680921(transcript)|ensembl:ENST00000681383(transcript)|ensembl:ENST00000681697(transcript)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004467"(long-chain fatty acid-CoA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:0035336"(long-chain fatty-acyl-CoA metabolic process)|go:"GO:0035338"(long-chain fatty-acyl-CoA biosynthetic process)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0047676"(arachidonate-CoA ligase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:0090433"(palmitoyl-CoA ligase activity)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000873(AMP-dependent synthetase and ligase)|interpro:IPR020845|mint:O95573|reactome:R-HSA-434313|reactome:R-HSA-75876 psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:L5tCBPOlL45uh0aUFi4algZQ5nY9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P55084 intact:EBI-6248147 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O14980 intact:EBI-6248147 intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9HAV4 intact:EBI-6248147 intact:EBI-517949|uniprotkb:Q5JTE6|uniprotkb:Q96G48|uniprotkb:Q96HN3|uniprotkb:Q9BWM6|uniprotkb:Q9BZV5|uniprotkb:Q9H9M4|uniprotkb:Q9NT89|uniprotkb:Q9NW39|uniprotkb:Q9ULC9|ensembl:ENSP00000265351 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:xpo5_human(display_long)|uniprotkb:Ran-binding protein 21(gene name synonym)|uniprotkb:XPO5(gene name)|psi-mi:XPO5(display_short)|uniprotkb:KIAA1291(gene name synonym)|uniprotkb:RANBP21(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_065801.1|dip:DIP-34547N|rcsb pdb:5YU7|reactome:R-HSA-203927|ensembl:ENSG00000124571(gene)|ensembl:ENST00000265351(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035281"(pre-miRNA export from nucleus)|go:"GO:0042565"(RNA nuclear export complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:1900370"(positive regulation of RNA interference)|go:"GO:1905172"(RISC complex binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040018|mint:Q9HAV4|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|rcsb pdb:3A6P|rcsb pdb:5YU6 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:wuUAxvyCl/u7CRtQLMK9McSoUrM9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O14828 intact:EBI-6248147 intact:EBI-4401333|ensembl:ENSP00000307275|ensembl:ENSP00000461521|uniprotkb:A9Z1W6|uniprotkb:B1AVS6|uniprotkb:O15128|uniprotkb:Q96FR8|uniprotkb:Q9BPY0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:scam3_human(display_long)|uniprotkb:SCAMP3(gene name)|psi-mi:SCAMP3(display_short)|uniprotkb:C1orf3(gene name synonym)|uniprotkb:PROPIN1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000116521(gene)|ensembl:ENSG00000263290(gene)|ensembl:ENST00000302631(transcript)|ensembl:ENST00000570831(transcript)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O14828|ensembl:ENSP00000307275|ensembl:ENST00000355379|ensembl:ENSP00000347540|ensembl:ENSP00000461521|ensembl:ENST00000573013|ensembl:ENSP00000458542|refseq:NP_005689.2|refseq:NP_443069.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:q1GaoVa7cLS2hGHVUM5Nv2oX4x09606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96P70 intact:EBI-6248147 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z psi-mi:"MI:0096"(pull down) - author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9Y6D5 intact:EBI-6248147 intact:EBI-2837511|uniprotkb:Q9NTS1|uniprotkb:Q5TFT9|ensembl:ENSP00000360985 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:big2_human(display_long)|uniprotkb:ARFGEF2(gene name)|psi-mi:ARFGEF2(display_short)|uniprotkb:ARFGEP2(gene name synonym)|uniprotkb:BIG2(gene name synonym)|uniprotkb:ADP-ribosylation factor guanine nucleotide-exchange factor 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_006411.2|ensembl:ENSG00000124198(gene)|ensembl:ENST00000371917(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001881"(receptor recycling)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005879"(axonemal microtubule)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0010256"(endomembrane system organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032280"(symmetric synapse)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0055037"(recycling endosome)|interpro:IPR000904(SEC7-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015403(Protein of unknown function DUF1981, SEC7 associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023394|interpro:IPR032629|interpro:IPR032691|interpro:IPR035999|rcsb pdb:3L8N|rcsb pdb:3SWV|reactome:R-HSA-390471|go:"GO:0005794"(Golgi apparatus)|dip:DIP-48794N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:y64XGrD2XxX6vTmWOW0hbjDzDCk9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P49792 intact:EBI-6248147 intact:EBI-973138|intact:EBI-28970106|ensembl:ENSP00000283195|uniprotkb:Q13074|uniprotkb:Q15280|uniprotkb:Q53TE2|uniprotkb:Q59FH7 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rbp2_human(display_long)|uniprotkb:RANBP2(gene name)|psi-mi:RANBP2(display_short)|uniprotkb:NUP358(gene name synonym)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Nuclear pore complex protein Nup358(gene name synonym)|uniprotkb:Nucleoporin Nup358(gene name synonym)|uniprotkb:358 kDa nucleoporin(gene name synonym)|uniprotkb:p270(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176256|imex:IM-17346-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000153201(gene)|ensembl:ENST00000283195(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|reactome:R-HSA-168271|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:P49792|reactome:R-HSA-168276|rcsb pdb:1RRP|reactome:R-HSA-168325|reactome:R-HSA-168333|rcsb pdb:1XKE|rcsb pdb:1Z5S|rcsb pdb:2LAS|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:4GA0|rcsb pdb:4I9Y|rcsb pdb:4L6E|rcsb pdb:4LQW|rcsb pdb:5CLL|rcsb pdb:5CLQ|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-170822|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-180746|reactome:R-HSA-9648025|ensembl:ENSP00000283195|refseq:NP_006258.3|dip:DIP-37654N psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/07/09 2018/09/18 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:KB+rjfw8djVygvDpTncA0NO2MDY9606 intact-crc:F4B06483783D98C8|rigid:h9n5aBdJfhW0JoL6GjaFwUzTuaE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q5BKY9 intact:EBI-6179761 intact:EBI-6165724|ensembl:ENSP00000398401|uniprotkb:B2R994|uniprotkb:Q05D67|uniprotkb:Q6P5S6|uniprotkb:Q8N0W8 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:f133b_human(display_long)|uniprotkb:FAM133B(gene name)|psi-mi:FAM133B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000234545(gene)|ensembl:ENST00000445716(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR026766|refseq:XP_011514306.1|refseq:NP_001035146.1|refseq:NP_690002.2|refseq:NP_001275513.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:ozckFn8fi/3T9XNK3Si7qw2fEWw9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q13217 intact:EBI-6179761 intact:EBI-6165721|ensembl:ENSP00000473631|uniprotkb:Q86WT9|uniprotkb:Q8N4N2 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:dnjc3_human(display_long)|uniprotkb:DNAJC3(gene name)|psi-mi:DNAJC3(display_short)|uniprotkb:Interferon-induced, double-stranded RNA-activated protein kinase inhibitor(gene name synonym)|uniprotkb:P58IPK(gene name synonym)|uniprotkb:PRKRI(gene name synonym)|uniprotkb:Protein kinase inhibitor of 58 kDa(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000102580(gene)|ensembl:ENST00000602402(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036494"(positive regulation of translation initiation in response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070417"(cellular response to cold)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018704|interpro:IPR019734|interpro:IPR036869|rcsb pdb:2Y4T|rcsb pdb:2Y4U|reactome:R-HSA-192823|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-6798695|reactome:R-HSA-8957275|refseq:NP_006251.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:p5PToTl/u3ZL9PtRSjDK01FKJmc9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P27797 intact:EBI-6179761 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.98 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q3MHD2 intact:EBI-6179761 intact:EBI-725133|uniprotkb:Q86YB1|uniprotkb:Q96NL5|ensembl:ENSP00000293406|ensembl:ENSP00000466718 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lsm12_human(display_long)|uniprotkb:LSM12(gene name)|psi-mi:LSM12(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_689557.1|ensembl:ENSG00000161654(gene)|ensembl:ENST00000293406(transcript)|ensembl:ENST00000591247(transcript)|interpro:IPR019181|interpro:IPR039683|mint:Q3MHD2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:SY9HUXXLZyXhttFb+AXkMh0QOek9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P13612 intact:EBI-6179761 intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9UN86 intact:EBI-6179761 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q8NBS9 intact:EBI-6179761 intact:EBI-2510815|ensembl:ENSP00000369081|uniprotkb:Q8TCT2|uniprotkb:Q5TCQ0|uniprotkb:Q9BVH9|uniprotkb:Q8ND33|uniprotkb:B2RDM2 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:txnd5_human(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|rcsb pdb:2DIZ|rcsb pdb:3UJ1|rcsb pdb:3UVT|rcsb pdb:3WGD|rcsb pdb:3WGE|rcsb pdb:3WGX|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001139021.1|refseq:NP_110437.2|dip:DIP-53700N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.98 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:bz5VVWMPFLTRKwph60UFASjsFN49606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P14625 intact:EBI-6179761 intact:EBI-359129|uniprotkb:Q96A97|ensembl:ENSP00000299767 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:enpl_human(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:TRA1(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:GRP94(gene name synonym)|uniprotkb:gp96 homolog(gene name synonym)|uniprotkb:Tumor rejection antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_003290.1|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P14625|rcsb pdb:4NH9|reactome:R-HSA-1679131|reactome:R-HSA-3000480|reactome:R-HSA-381183|reactome:R-HSA-381426|reactome:R-HSA-6785807|reactome:R-HSA-8957275|ensembl:ENSG00000166598(gene)|ensembl:ENST00000299767(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|dip:DIP-36060N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:m5CdlplqVyMUWYe75aKDuMzztMY9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BS26 intact:EBI-6179761 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O15234 intact:EBI-6179761 intact:EBI-299118|ensembl:ENSP00000264645|uniprotkb:A8K8R0 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:casc3_human(display_long)|uniprotkb:CASC3(gene name)|psi-mi:CASC3(display_short)|uniprotkb:MLN51(gene name synonym)|uniprotkb:Cancer susceptibility candidate gene 3 protein(gene name synonym)|uniprotkb:Metastatic lymph node gene 51 protein(gene name synonym)|uniprotkb:Protein barentsz(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0008298"(intracellular mRNA localization)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|interpro:IPR018545|interpro:IPR028544|ensembl:ENSG00000108349(gene)|ensembl:ENST00000264645(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2J0U|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|refseq:NP_031385.2|refseq:XP_005257220.1|dip:DIP-33288N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:62nwK5KCrjsyaY7WKPlfUAPhohM9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P04439 intact:EBI-6179761 intact:EBI-1042870|uniprotkb:O02963|uniprotkb:O78073|uniprotkb:P79563|uniprotkb:Q30208|uniprotkb:Q31623|uniprotkb:Q95377|uniprotkb:Q9BD15|uniprotkb:Q9BD19|uniprotkb:Q9MW42|uniprotkb:Q9TQK5|ensembl:ENSP00000366005|ensembl:ENSP00000379873|intact:EBI-1050524|intact:EBI-1049899|intact:EBI-2839447|intact:EBI-1044129|intact:EBI-8770309|intact:EBI-21249599|uniprotkb:B1PKZ3|uniprotkb:O02939|uniprotkb:O02954|uniprotkb:O02955|uniprotkb:O19509|uniprotkb:O19546|uniprotkb:O19598|uniprotkb:O19605|uniprotkb:O19606|uniprotkb:O19619|uniprotkb:O19647|uniprotkb:O19673|uniprotkb:O19687|uniprotkb:O19695|uniprotkb:O19756|uniprotkb:O19794|uniprotkb:O19795|uniprotkb:O43906|uniprotkb:O43907|uniprotkb:O46874|uniprotkb:O62921|uniprotkb:O62924|uniprotkb:O77937|uniprotkb:O77938|uniprotkb:O77964|uniprotkb:O78171|uniprotkb:O98009|uniprotkb:P30455|uniprotkb:P30456|uniprotkb:P30457|uniprotkb:P30458|uniprotkb:O98010|uniprotkb:O98011|uniprotkb:O98137|uniprotkb:P01891|uniprotkb:P01892|uniprotkb:P05534|uniprotkb:P06338|uniprotkb:P10313|uniprotkb:P10314|uniprotkb:P10315|uniprotkb:P10316|uniprotkb:P13746|uniprotkb:P16188|uniprotkb:P16189|uniprotkb:P16190|uniprotkb:P18462|uniprotkb:P30443|uniprotkb:P30444|uniprotkb:P30445|uniprotkb:P30446|uniprotkb:P30447|uniprotkb:P30448|uniprotkb:P30449|uniprotkb:P30450|uniprotkb:P30451|uniprotkb:P30514|uniprotkb:P79505|uniprotkb:P79562|uniprotkb:Q09160|uniprotkb:Q29680|uniprotkb:P30512|uniprotkb:Q29747|uniprotkb:Q29835|uniprotkb:Q29837|uniprotkb:Q29838|uniprotkb:Q29899|uniprotkb:Q29908|uniprotkb:Q29909|uniprotkb:Q29910|uniprotkb:Q5S3G1|uniprotkb:Q65A82|uniprotkb:Q8MHM1|uniprotkb:Q8MHN9|uniprotkb:Q95352|uniprotkb:Q95355|uniprotkb:P30452|uniprotkb:P30459|uniprotkb:Q95380|uniprotkb:Q95IZ5|uniprotkb:Q9BCN0|uniprotkb:Q9GJE6|uniprotkb:Q9GJE7|uniprotkb:Q9GJE8|uniprotkb:Q9MY89|uniprotkb:Q9MYA3|uniprotkb:Q9MYA5|uniprotkb:Q9MYC4|uniprotkb:Q9MYE6|uniprotkb:Q9MYE9|uniprotkb:Q9MYG4|uniprotkb:Q9MYG5|uniprotkb:Q9MYI5|uniprotkb:Q9TP25|uniprotkb:Q9TPQ3|uniprotkb:Q9TPR8|uniprotkb:Q9TPX8|uniprotkb:Q9TPX9|uniprotkb:Q9TPY0|uniprotkb:Q95362|uniprotkb:Q9TQ24|uniprotkb:Q9TQE8|uniprotkb:Q9TQE9|uniprotkb:Q9TQF1|uniprotkb:Q9TQF5|uniprotkb:Q9TQF8|uniprotkb:Q9TQF9|uniprotkb:Q9TQG0|uniprotkb:Q9TQG5|uniprotkb:Q9TQG7|uniprotkb:Q9TQH5|uniprotkb:Q9TQI3|uniprotkb:Q9TQM6|uniprotkb:Q9TQN5|uniprotkb:Q9TQP5|uniprotkb:Q9TQP6|uniprotkb:Q9TQP7|uniprotkb:Q9UIN1|uniprotkb:Q9UIN2|uniprotkb:Q9UIP7|uniprotkb:Q9UQU3|uniprotkb:Q9UQU6|uniprotkb:Q9UQU7|uniprotkb:P30453|uniprotkb:P30454|intact:EBI-1050350|intact:EBI-21505155 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hlaa_human(display_long)|uniprotkb:HLA-A(gene name)|psi-mi:HLA-A(display_short)|uniprotkb:HLAA(gene name synonym)|uniprotkb:Human leukocyte antigen A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENST00000376809(transcript)|ensembl:ENST00000396634(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002419"(T cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002485"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent)|go:"GO:0002486"(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009986"(cell surface)|ensembl:ENSG00000206503(gene)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016045"(detection of bacterium)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030881"(beta-2-microglobulin binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0036037"(CD8-positive, alpha-beta T cell activation)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042612"(MHC class I protein complex)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045087"(innate immune response)|go:"GO:0046977"(TAP binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0062061"(TAP complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2000568"(positive regulation of memory T cell activation)|go:"GO:2001187"(positive regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010579(MHC class I, alpha chain, C-terminal)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037055|mint:P04439|rcsb pdb:1AKJ|rcsb pdb:1AO7|rcsb pdb:1AQD|rcsb pdb:1B0G|rcsb pdb:1B0R|rcsb pdb:1BD2|rcsb pdb:1DUY|rcsb pdb:1DUZ|rcsb pdb:1Q94|rcsb pdb:1QEW|rcsb pdb:1QR1|rcsb pdb:1QRN|rcsb pdb:1QSE|rcsb pdb:1QSF|rcsb pdb:1QVO|rcsb pdb:1S8D|rcsb pdb:1S9W|rcsb pdb:1S9X|rcsb pdb:1S9Y|rcsb pdb:1T1W|rcsb pdb:1T1X|rcsb pdb:1T1Y|rcsb pdb:1T1Z|rcsb pdb:1T20|rcsb pdb:1T21|rcsb pdb:1T22|rcsb pdb:1TMC|rcsb pdb:1TVB|rcsb pdb:1TVH|rcsb pdb:1UR7|rcsb pdb:1W72|rcsb pdb:1X7Q|rcsb pdb:2AV1|rcsb pdb:2AV7|rcsb pdb:2BCK|rcsb pdb:2BNQ|rcsb pdb:2BNR|rcsb pdb:2C7U|rcsb pdb:2CLR|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GIT|rcsb pdb:1P7Q|rcsb pdb:2GJ6|rcsb pdb:2GT9|rcsb pdb:2GTW|rcsb pdb:2GTZ|rcsb pdb:1EEY|rcsb pdb:1EEZ|rcsb pdb:1HHG|rcsb pdb:1HHH|rcsb pdb:1HHI|rcsb pdb:1HHJ|rcsb pdb:1HHK|rcsb pdb:1HLA|rcsb pdb:1HSB|rcsb pdb:1I1F|rcsb pdb:1I1Y|rcsb pdb:1I4F|rcsb pdb:1I7R|rcsb pdb:1I7T|rcsb pdb:1I7U|rcsb pdb:1IM3|rcsb pdb:1JF1|rcsb pdb:1JHT|rcsb pdb:1LP9|rcsb pdb:1OGA|rcsb pdb:5HGH|rcsb pdb:5HHM|rcsb pdb:5HHN|rcsb pdb:5HHO|rcsb pdb:5HHP|rcsb pdb:5HHQ|rcsb pdb:5HYJ|rcsb pdb:5IRO|rcsb pdb:5ISZ|rcsb pdb:5JHD|rcsb pdb:5JZI|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MEQ|rcsb pdb:5MER|rcsb pdb:5N1Y|rcsb pdb:5N6B|rcsb pdb:5NHT|rcsb pdb:3MR9|rcsb pdb:3MRB|rcsb pdb:3MRC|rcsb pdb:3MRD|rcsb pdb:3MRE|rcsb pdb:3MRF|rcsb pdb:3MRG|rcsb pdb:3MGT|rcsb pdb:3MRH|rcsb pdb:3MRI|rcsb pdb:3MRJ|rcsb pdb:3MRK|rcsb pdb:3MRL|rcsb pdb:3MRM|rcsb pdb:3MRN|rcsb pdb:3MRO|rcsb pdb:3MRP|rcsb pdb:3MRQ|rcsb pdb:3MRR|rcsb pdb:3MYJ|rcsb pdb:3NFN|rcsb pdb:3O3A|rcsb pdb:3O3B|rcsb pdb:3O3D|rcsb pdb:3O3E|rcsb pdb:3O4L|rcsb pdb:3PWJ|rcsb pdb:3PWL|rcsb pdb:3PWN|rcsb pdb:3PWP|rcsb pdb:3QDG|rcsb pdb:3QDJ|rcsb pdb:3QDM|rcsb pdb:3QEQ|rcsb pdb:3QFD|rcsb pdb:3QFJ|rcsb pdb:3QZW|rcsb pdb:3REW|rcsb pdb:3RL1|rcsb pdb:3RL2|rcsb pdb:3TO2|rcsb pdb:3UTQ|rcsb pdb:3UTS|rcsb pdb:3UTT|rcsb pdb:3V5D|rcsb pdb:3V5H|rcsb pdb:3V5K|rcsb pdb:3VXM|rcsb pdb:3VXN|rcsb pdb:3VXO|rcsb pdb:3VXP|rcsb pdb:3VXR|rcsb pdb:3VXS|rcsb pdb:3VXU|rcsb pdb:3W0W|rcsb pdb:3WL9|rcsb pdb:3WLB|rcsb pdb:4E5X|rcsb pdb:4EMZ|rcsb pdb:4EN2|rcsb pdb:4EUP|rcsb pdb:4F7M|rcsb pdb:4F7P|rcsb pdb:4F7T|rcsb pdb:4FTV|rcsb pdb:4L29|rcsb pdb:4L3C|rcsb pdb:4L3E|rcsb pdb:4MJ5|rcsb pdb:4MJ6|rcsb pdb:4MNQ|rcsb pdb:4N8V|rcsb pdb:4NNX|rcsb pdb:4NNY|rcsb pdb:4NO0|rcsb pdb:4NO2|rcsb pdb:4NO3|rcsb pdb:4GKN|rcsb pdb:4NO5|rcsb pdb:4NQV|rcsb pdb:4NQX|rcsb pdb:4OV5|rcsb pdb:4QOK|rcsb pdb:4U6X|rcsb pdb:4GKS|rcsb pdb:4HWZ|rcsb pdb:4HX1|rcsb pdb:4U6Y|rcsb pdb:4UQ2|rcsb pdb:4UQ3|rcsb pdb:4I48|rcsb pdb:4WJ5|rcsb pdb:4I4W|rcsb pdb:4WU5|rcsb pdb:4JFD|rcsb pdb:4WU7|rcsb pdb:4WUU|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFO|rcsb pdb:4JFP|rcsb pdb:4JFQ|rcsb pdb:4K7F|rcsb pdb:5BRZ|rcsb pdb:5BS0|rcsb pdb:5C07|rcsb pdb:5C08|rcsb pdb:5C09|rcsb pdb:5C0A|rcsb pdb:5C0B|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:5NQK|rcsb pdb:5SWQ|rcsb pdb:5TEZ|rcsb pdb:5W1W|rcsb pdb:5WJL|rcsb pdb:5WJN|rcsb pdb:5WKF|rcsb pdb:5WKH|rcsb pdb:5WSH|rcsb pdb:5WWI|rcsb pdb:5WWJ|rcsb pdb:5WWU|rcsb pdb:5WXC|rcsb pdb:5WXD|rcsb pdb:5XOV|rcsb pdb:5YXN|rcsb pdb:5YXU|rcsb pdb:6AM5|rcsb pdb:6AMT|rcsb pdb:6AMU|rcsb pdb:6APN|rcsb pdb:6AT9|rcsb pdb:6D78|rcsb pdb:6D7G|rcsb pdb:6DKP|rcsb pdb:6EI2|rcsb pdb:6ENY|rcsb pdb:6EQA|rcsb pdb:6EQB|rcsb pdb:5NME|rcsb pdb:5C0D|rcsb pdb:5C0E|rcsb pdb:5C0C|rcsb pdb:5C0F|rcsb pdb:5C0G|rcsb pdb:5C0I|rcsb pdb:5C0J|rcsb pdb:5D2L|rcsb pdb:5D2N|rcsb pdb:5D9S|rcsb pdb:5DDH|rcsb pdb:5E00|rcsb pdb:5E6I|rcsb pdb:5E9D|rcsb pdb:5ENW|rcsb pdb:5EOT|rcsb pdb:5EU3|rcsb pdb:5EU4|rcsb pdb:5EU5|rcsb pdb:5EU6|rcsb pdb:5EUO|rcsb pdb:5F7D|rcsb pdb:5F9J|rcsb pdb:5FA3|rcsb pdb:5FA4|rcsb pdb:5FDW|rcsb pdb:5GRD|rcsb pdb:5GRG|rcsb pdb:5GSD|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:6EWA|rcsb pdb:6SS7|rcsb pdb:6SS8|rcsb pdb:6SS9|rcsb pdb:6SSA|reactome:R-HSA-1236974|reactome:R-HSA-1236977|reactome:R-HSA-164940|reactome:R-HSA-198933|reactome:R-HSA-6798695|reactome:R-HSA-877300|reactome:R-HSA-8866654|reactome:R-HSA-909733|reactome:R-HSA-983170|rcsb pdb:6RSY|rcsb pdb:6EWC|rcsb pdb:6EWO|rcsb pdb:6G3J|rcsb pdb:6G3K|rcsb pdb:6ID4|rcsb pdb:6J1W|rcsb pdb:6J29|rcsb pdb:6J2A|rcsb pdb:6JOZ|rcsb pdb:6JP3|rcsb pdb:6MPP|rcsb pdb:6NCA|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6OPD|rcsb pdb:6PBH|rcsb pdb:6PTB|rcsb pdb:6PTE|rcsb pdb:6Q3K|rcsb pdb:6Q3S|rcsb pdb:6R2L|rcsb pdb:6RP9|rcsb pdb:6RPA|rcsb pdb:6RPB|rcsb pdb:2GUO|rcsb pdb:2HLA|rcsb pdb:2HN7|rcsb pdb:2J8U|rcsb pdb:2JCC|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PYE|rcsb pdb:2UWE|rcsb pdb:2V2W|rcsb pdb:2V2X|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLL|rcsb pdb:2VLR|rcsb pdb:2X4N|rcsb pdb:2X4O|rcsb pdb:2X4P|rcsb pdb:2X4Q|rcsb pdb:2X4R|rcsb pdb:2X4S|rcsb pdb:2X4T|rcsb pdb:2X4U|rcsb pdb:2X70|rcsb pdb:2XPG|rcsb pdb:3BGM|rcsb pdb:3BH8|rcsb pdb:3BH9|rcsb pdb:3BHB|rcsb pdb:3BO8|rcsb pdb:3D25|rcsb pdb:3D39|rcsb pdb:3D3V|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:3FQW|rcsb pdb:3FQX|rcsb pdb:3FT2|rcsb pdb:3FT3|rcsb pdb:3FT4|rcsb pdb:3GIV|rcsb pdb:3GJF|rcsb pdb:3GSN|rcsb pdb:3GSO|rcsb pdb:3GSQ|rcsb pdb:3GSR|rcsb pdb:3GSU|rcsb pdb:3GSV|rcsb pdb:3GSW|rcsb pdb:3GSX|rcsb pdb:3H7B|rcsb pdb:3H9H|rcsb pdb:3H9S|rcsb pdb:3HAE|rcsb pdb:3HLA|rcsb pdb:3HPJ|rcsb pdb:3I6G|rcsb pdb:3I6K|rcsb pdb:3I6L|rcsb pdb:3IXA|rcsb pdb:3KLA|rcsb pdb:3MGO|refseq:NP_002107.3|refseq:NP_001229687.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:RNvdwEiEB2h1Qfvd4BEIKiGzw1s9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q13112 intact:EBI-6179761 intact:EBI-1052944|uniprotkb:Q99548|ensembl:ENSP00000315700 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:caf1b_human(display_long)|uniprotkb:Chromatin assembly factor I p60 subunit(gene name synonym)|uniprotkb:M-phase phosphoprotein 7(gene name synonym)|uniprotkb:CHAF1B(gene name)|psi-mi:CHAF1B(display_short)|uniprotkb:CAF1A(gene name synonym)|uniprotkb:CAF1P60(gene name synonym)|uniprotkb:MPHOSPH7(gene name synonym)|uniprotkb:MPP7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005432.1|dip:DIP-29243N|ensembl:ENSG00000159259(gene)|ensembl:ENST00000314103(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR029129|interpro:IPR036322|mint:Q13112|refseq:XP_016883966.1|refseq:XP_016883967.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:VVbW9mpUGYMRPxvlEk9FERHIsJs9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9UI08 intact:EBI-6179761 intact:EBI-346653|uniprotkb:O95884|uniprotkb:Q7Z522|uniprotkb:Q8TBV1|uniprotkb:Q9UF25|uniprotkb:A8K105|uniprotkb:Q9UIC2|uniprotkb:B7Z3I5|ensembl:ENSP00000384720 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:evl_human(display_long)|uniprotkb:EVL(gene name)|psi-mi:EVL(display_short)|uniprotkb:RNB6(gene name synonym)|uniprotkb:Ena/vasodilator-stimulated phosphoprotein-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_057421.1|refseq:NP_001317150.1|ensembl:ENSG00000196405(gene)|ensembl:ENST00000402714(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0045010"(actin nucleation)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:1900028"(negative regulation of ruffle assembly)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014885(VASP tetramerisation)|interpro:IPR017354(Vasodilator-stimulated phosphoprotein)|interpro:IPR034319|interpro:IPR038023|mint:Q9UI08|reactome:R-HSA-202433|reactome:R-HSA-376176|reactome:R-HSA-5663220 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:ZYA6pfvqC68sm/0egUg4hBif/Pc9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P17066 intact:EBI-6179761 intact:EBI-355106|uniprotkb:Q8IYK7|uniprotkb:Q9BT95|uniprotkb:Q1HBA8|ensembl:ENSP00000310219 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hsp76_human(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002146.2|ensembl:ENSG00000173110(gene)|ensembl:ENST00000309758(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P17066|rcsb pdb:3FE1|reactome:R-HSA-3371453|reactome:R-HSA-6798695 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:AcNwJ2S/RD3n/8iRNy5ioetVZ+U9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O14656 intact:EBI-6179761 intact:EBI-524257|uniprotkb:Q53Y64|uniprotkb:Q96CA0|uniprotkb:B2RB58|ensembl:ENSP00000345719 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tor1a_human(display_long)|uniprotkb:Torsin family 1 member A(gene name synonym)|uniprotkb:Dystonia 1 protein(gene name synonym)|uniprotkb:TOR1A(gene name)|psi-mi:TOR1A(display_short)|uniprotkb:DQ2(gene name synonym)|uniprotkb:DYT1(gene name synonym)|uniprotkb:TA(gene name synonym)|uniprotkb:Torsin ATPase-1A(gene name synonym)|uniprotkb:TORA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000136827(gene)|ensembl:ENST00000351698(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006996"(organelle organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030426"(growth cone)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051584"(regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061992"(obsolete ATP-dependent chaperone mediated protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071763"(nuclear membrane organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:2000008"(regulation of protein localization to cell surface)|interpro:IPR010448(Torsin)|interpro:IPR017378(Torsin, subgroup)|interpro:IPR027417|interpro:IPR030549|rcsb pdb:5J1S|rcsb pdb:5J1T|rcsb pdb:6OIF|reactome:R-HSA-8856825|go:"GO:0031175"(neuron projection development)|refseq:NP_000104.1|dip:DIP-34411N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:PeqPtp4z9AnOwDH1GXYATMaihkM9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BTV4 intact:EBI-6179761 intact:EBI-721293|uniprotkb:Q7L4N5|uniprotkb:Q8NC30|uniprotkb:Q96A63|uniprotkb:Q96F19|uniprotkb:Q96JX0|uniprotkb:Q9H076|ensembl:ENSP00000303992 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tmm43_human(display_long)|uniprotkb:TMEM43(gene name)|psi-mi:TMEM43(display_short)|uniprotkb:UNQ2564/PRO6244(orf name)|uniprotkb:Protein LUMA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_077310.1|ensembl:ENSG00000170876(gene)|ensembl:ENST00000306077(transcript)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0071763"(nuclear membrane organization)|interpro:IPR012430(Protein of unknown function DUF1625) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:8VCyVNtrzh7J9uJ2EjQLBhJGrfc9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q13724 intact:EBI-6179761 intact:EBI-720141|uniprotkb:Q17RN9|uniprotkb:Q8TCT5|uniprotkb:A8K938|ensembl:ENSP00000410992|uniprotkb:F5H6D0 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:mogs_human(display_long)|uniprotkb:Processing A-glucosidase I(gene name synonym)|uniprotkb:MOGS(gene name)|psi-mi:MOGS(display_short)|uniprotkb:GCS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001139630.1|refseq:NP_006293.2|ensembl:ENSG00000115275(gene)|ensembl:ENST00000448666(transcript)|go:"GO:0004573"(Glc3Man9GlcNAc2 oligosaccharide glucosidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0015926"(glucosidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004888(Glycoside hydrolase, family 63)|interpro:IPR008928(Six-hairpin glycosidase-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR031335|interpro:IPR031631|interpro:IPR038518|mint:Q13724|reactome:R-HSA-4793954|reactome:R-HSA-532668|reactome:R-HSA-9683686|reactome:R-HSA-9694548 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:odbL3NUcP483ilKg/CMVn2GtdVs9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BV68 intact:EBI-6179761 intact:EBI-357322|ensembl:ENSP00000292363|uniprotkb:Q9NWX1|intact:EBI-11064977 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rn126_human(display_long)|uniprotkb:RNF126(gene name)|psi-mi:RNF126(display_short)|uniprotkb:RING finger protein 126(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000070423(gene)|ensembl:ENST00000292363(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR039525|interpro:IPR039571|interpro:IPR039572|rcsb pdb:2N9O|rcsb pdb:2N9P|reactome:R-HSA-983168|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_919442.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:4Z4AJGHJgoIUp9zhtfWcFBF1Fxw9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BUT9 intact:EBI-6179761 intact:EBI-721265|uniprotkb:Q969E9|uniprotkb:Q96KV8|ensembl:ENSP00000305138 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:mcri2_human(display_long)|uniprotkb:MCRIP2(gene name)|psi-mi:MCRIP2(display_short)|uniprotkb:C16orf14(gene name synonym)|uniprotkb:FAM195A(gene name synonym)|uniprotkb:Protein FAM195A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_612427.2|refseq:NP_001318158.1|refseq:NP_001318159.1|ensembl:ENSG00000172366(gene)|ensembl:ENST00000307650(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010494"(cytoplasmic stress granule)|interpro:IPR029428 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:TJx/zjepOoY37UX7SmqiOjU0RPE9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O43852 intact:EBI-6179761 intact:EBI-1171069|uniprotkb:O60456|uniprotkb:Q6FHB9|uniprotkb:Q96RL3|uniprotkb:Q9NR43|intact:EBI-2554631|uniprotkb:B3KPG9|uniprotkb:D6QS48|uniprotkb:D6QS49|uniprotkb:D6QS50|uniprotkb:D6QS51|uniprotkb:D6QS52|uniprotkb:D6QS53|uniprotkb:D6QS54|uniprotkb:D6QS55|uniprotkb:D6QS56|uniprotkb:D6QS57|uniprotkb:D6QS58|uniprotkb:D6QS59|uniprotkb:F5H1Q9|uniprotkb:F5H879|ensembl:ENSP00000249364 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calu_human(display_long)|uniprotkb:CALU(gene name)|psi-mi:CALU(display_short)|uniprotkb:Crocalbin(gene name synonym)|uniprotkb:IEF SSP 9302(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001124146.1|refseq:NP_001186602.1|refseq:NP_001210.1|refseq:NP_001186600.1|refseq:NP_001186601.1|ensembl:ENSG00000128595(gene)|ensembl:ENST00000249364(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|mint:O43852|reactome:R-HSA-114608|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:XP_016868148.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:lgl1dEYzu+XFHq3QJ/w69xg51Ts9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9UBS4 intact:EBI-6179761 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q12805 intact:EBI-6179761 intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q99470 intact:EBI-6179761 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.98 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q14257 intact:EBI-6179761 intact:EBI-356710|uniprotkb:A8MTG6|uniprotkb:Q53XN8|ensembl:ENSP00000378349|uniprotkb:F8WCY5 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rcn2_human(display_long)|uniprotkb:RCN2(gene name)|psi-mi:RCN2(display_short)|uniprotkb:ERC55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:E6-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_002893.1|ensembl:ENST00000394885(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|ensembl:ENSG00000117906(gene)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q14257|refseq:NP_001258766.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.99 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:99ru/7eYUvZ5xdb+x4inbib3PP89606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P61619 intact:EBI-6179761 intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P26196 intact:EBI-6179761 intact:EBI-351257|uniprotkb:Q5D048|ensembl:ENSP00000433704|ensembl:ENSP00000442266|ensembl:ENSP00000478754 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ddx6_human(display_long)|uniprotkb:DDX6(gene name)|psi-mi:DDX6(display_short)|uniprotkb:HLR2(gene name synonym)|uniprotkb:RCK(gene name synonym)|uniprotkb:DEAD box protein 6(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p54(gene name synonym)|uniprotkb:Oncogene RCK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_004388.2|refseq:NP_001244120.1|ensembl:ENSG00000110367(gene)|ensembl:ENST00000526070(transcript)|ensembl:ENST00000534980(transcript)|ensembl:ENST00000620157(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0000932"(P-body)|go:"GO:0001520"(outer dense fiber)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019074"(viral RNA genome packaging)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045296"(cadherin binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0061830"(concave side of sperm head)|go:"GO:0097227"(sperm annulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:P26196|rcsb pdb:1VEC|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT5|rcsb pdb:5ANR|rcsb pdb:6F9S|rcsb pdb:6S8S|reactome:R-HSA-430039|refseq:XP_005271474.1|dip:DIP-29195N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:pBOpwnVU+BmxUyC/uo2ig53QRto9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9Y4L1 intact:EBI-6179761 intact:EBI-1054186|uniprotkb:Q2I204|uniprotkb:Q53H25|uniprotkb:B7Z909|uniprotkb:A8C1Z0|ensembl:ENSP00000480150|ensembl:ENSP00000486825 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hyou1_human(display_long)|uniprotkb:150 kDa oxygen-regulated protein(gene name synonym)|uniprotkb:GRP170(gene name synonym)|uniprotkb:HYOU1(gene name)|psi-mi:HYOU1(display_short)|uniprotkb:ORP150(gene name synonym)|uniprotkb:170 kDa glucose-regulated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001124463.1|refseq:NP_006380.1|refseq:XP_016872585.1|refseq:XP_016872586.1|ensembl:ENSG00000149428(gene)|ensembl:ENSG00000280682(gene)|ensembl:ENST00000617285(transcript)|ensembl:ENST00000630669(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:Q9Y4L1|reactome:R-HSA-3000484|reactome:R-HSA-381038|go:"GO:0005790"(smooth endoplasmic reticulum) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:xqSFRaiiHJLNVqgh87tHx9lfnS49606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9NYJ8 intact:EBI-6179761 intact:EBI-358708|uniprotkb:O94838|uniprotkb:Q6I9W8|uniprotkb:Q76N06|uniprotkb:Q9UFP7|uniprotkb:E1P5A0|uniprotkb:B2RCC4|ensembl:ENSP00000356426|ensembl:ENSP00000445752|ensembl:ENSP00000490618 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tab2_human(display_long)|uniprotkb:TAB2(gene name)|psi-mi:TAB2(display_short)|uniprotkb:KIAA0733(gene name synonym)|uniprotkb:MAP3K7IP2(gene name synonym)|uniprotkb:TAK1-binding protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_055908.1|refseq:NP_001278963.1|refseq:NP_001278964.1|refseq:XP_011533935.1|ensembl:ENST00000637181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000538427(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|mint:Q9NYJ8|rcsb pdb:2DAE|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1|reactome:R-HSA-1251985|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|ensembl:ENST00000367456(transcript)|ensembl:ENSG00000055208(gene)|refseq:XP_016866080.1|refseq:XP_016866081.1|dip:DIP-27525N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:hMWL5GobXJSsm8ToWVBF/ZwPX3M9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P05107 intact:EBI-6179761 intact:EBI-300173|ensembl:ENSP00000303242|ensembl:ENSP00000347279|ensembl:ENSP00000380948|ensembl:ENSP00000380950|ensembl:ENSP00000380955|uniprotkb:Q16418|uniprotkb:B3KTS8|uniprotkb:Q53HS5|uniprotkb:Q9UD72|uniprotkb:D3DSM1 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:itb2_human(display_long)|uniprotkb:ITGB2(gene name)|psi-mi:ITGB2(display_short)|uniprotkb:CD18(gene name synonym)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:MFI7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0034689"(integrin alphaX-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043113"(receptor clustering)|ensembl:ENSG00000160255(gene)|ensembl:ENST00000302347(transcript)|ensembl:ENST00000355153(transcript)|ensembl:ENST00000397850(transcript)|ensembl:ENST00000397852(transcript)|ensembl:ENST00000397857(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:1990266"(neutrophil migration)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|go:"GO:0046872"(metal ion binding)|interpro:IPR036465|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|mint:P05107|rcsb pdb:1JX3|rcsb pdb:1L3Y|rcsb pdb:1YUK|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:2JF1|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2P26|rcsb pdb:2P28|rcsb pdb:2V7D|rcsb pdb:3K6S|rcsb pdb:3K71|rcsb pdb:3K72|go:"GO:0070821"(tertiary granule membrane)|rcsb pdb:4NEH|rcsb pdb:4NEN|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:5E6V|rcsb pdb:5E6W|rcsb pdb:5E6X|rcsb pdb:5ES4|rcsb pdb:5XR1|rcsb pdb:5ZAZ|reactome:R-HSA-166016|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695|refseq:NP_000202.3|refseq:NP_001120963.2|refseq:NP_001290167.1|dip:DIP-478N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:aaycm8Q/rmu01cs20dw399oJjFE9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P50454 intact:EBI-6179761 intact:EBI-350723|uniprotkb:P29043|uniprotkb:Q5XPB4|uniprotkb:Q6NSJ6|uniprotkb:Q8IY96|uniprotkb:Q9NP88|uniprotkb:B3KVJ3|ensembl:ENSP00000350894|ensembl:ENSP00000434412|ensembl:ENSP00000434657 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:serph_human(display_long)|uniprotkb:SERPINH1(gene name)|psi-mi:SERPINH1(display_short)|uniprotkb:CBP2(gene name synonym)|uniprotkb:Collagen-binding protein(gene name synonym)|uniprotkb:47 kDa heat shock protein(gene name synonym)|uniprotkb:Rheumatoid arthritis-related antigen RA-A47(gene name synonym)|uniprotkb:Arsenic-transactivated protein 3(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 14 protein(gene name synonym)|uniprotkb:CBP1(gene name synonym)|uniprotkb:HSP47(gene name synonym)|uniprotkb:SERPINH2(gene name synonym)|uniprotkb:PIG14(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001193943.1|refseq:NP_001226.2|go:"GO:0003723"(RNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033547|interpro:IPR033830|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P50454|reactome:R-HSA-1650814|ensembl:ENSG00000149257(gene)|ensembl:ENST00000358171(transcript)|ensembl:ENST00000524558(transcript)|ensembl:ENST00000533603(transcript)|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|refseq:XP_011543629.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:cO3NR2hb0NyOs99Sq1aODePlDR09606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P01130 intact:EBI-6179761 intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9H0U3 intact:EBI-6179761 intact:EBI-2798816|uniprotkb:Q6P577|uniprotkb:B2RAR4|uniprotkb:Q53G00|uniprotkb:Q8NBN6|uniprotkb:D3DTE3|ensembl:ENSP00000354649|ensembl:ENSP00000480732 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:magt1_human(display_long)|uniprotkb:IAG2(gene name synonym)|uniprotkb:Implantation-associated protein(gene name synonym)|uniprotkb:PSEC0084(orf name)|uniprotkb:UNQ628/PRO1244(orf name)|uniprotkb:MAGT1(gene name)|psi-mi:MAGT1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_115497.4|ensembl:ENSG00000102158(gene)|ensembl:ENST00000358075(transcript)|ensembl:ENST00000618282(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0015095"(magnesium ion transmembrane transporter activity)|go:"GO:0015693"(magnesium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0055085"(transmembrane transport)|interpro:IPR006844(OST3/OST6)|interpro:IPR021149|interpro:IPR036249|mint:Q9H0U3|rcsb pdb:6S7T|reactome:R-HSA-446203|reactome:R-HSA-5223345|reactome:R-HSA-6798695|reactome:R-HSA-9694548|go:"GO:0050890"(cognition) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:M7/LTAlkuCCyeqlTlcJkfu2HU9k9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P48723 intact:EBI-6179761 intact:EBI-750892|uniprotkb:Q8NE40|uniprotkb:B2R616|ensembl:ENSP00000285667 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hsp13_human(display_long)|uniprotkb:STCH(gene name synonym)|uniprotkb:Stress-70 protein chaperone microsome-associated 60 kDa protein(gene name synonym)|uniprotkb:Microsomal stress-70 protein ATPase core(gene name synonym)|uniprotkb:HSPA13(gene name)|psi-mi:HSPA13(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_008879.3|ensembl:ENSG00000155304(gene)|ensembl:ENST00000285667(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR042048|interpro:IPR043129|reactome:R-HSA-3371453 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:pR8UOE4IPZn0dO9d00dbTGOoV+89606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q96EE3 intact:EBI-6179761 intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q8NFQ8 intact:EBI-6179761 intact:EBI-524567|ensembl:ENSP00000356584|ensembl:ENSP00000477486 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:toip2_human(display_long)|uniprotkb:Lumenal domain-like LAP1(gene name synonym)|uniprotkb:TOR1AIP2(gene name)|psi-mi:TOR1AIP2(display_short)|uniprotkb:LULL1(gene name synonym)|uniprotkb:IFRG15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:XP_005244996.1|interpro:IPR008662(Lamina-associated polypeptide 1C)|ensembl:ENSG00000169905(gene)|ensembl:ENST00000367612(transcript)|ensembl:ENST00000609928(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0061024"(membrane organization)|go:"GO:0090435"(protein localization to nuclear envelope)|refseq:XP_016855963.1|refseq:XP_016855964.1|refseq:NP_001186189.1|refseq:NP_659471.1|interpro:IPR038599|rcsb pdb:5J1S|rcsb pdb:5J1T psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:HjY3sLjzR1jmKq2EqIKRvY3GxKc9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BRK5 intact:EBI-6179761 intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:O14967 intact:EBI-6179761 intact:EBI-3907005|uniprotkb:D3DNY8|uniprotkb:B3KS90|uniprotkb:B4DXV8|ensembl:ENSP00000326699|ensembl:ENSP00000392782 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:clgn_human(display_long)|uniprotkb:CLGN(gene name)|psi-mi:CLGN(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001124147.1|refseq:NP_004353.1|ensembl:ENSG00000153132(gene)|ensembl:ENST00000325617(transcript)|ensembl:ENST00000414773(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:O14967 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:Akb2XoiNjob34njC2erE11yg80w9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q8NBJ5 intact:EBI-6179761 intact:EBI-1057068|uniprotkb:Q8NC64|ensembl:ENSP00000252599 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:gt251_human(display_long)|uniprotkb:COLGALT1(gene name)|psi-mi:COLGALT1(display_short)|uniprotkb:"Collagen beta(1-O)galactosyltransferase 1"(gene name synonym)|uniprotkb:GLT25D1(gene name synonym)|uniprotkb:Glycosyltransferase 25 family member 1(gene name synonym)|uniprotkb:Hydroxylysine galactosyltransferase 1(gene name synonym)|uniprotkb:PSEC0241(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_078932.2|ensembl:ENSG00000130309(gene)|ensembl:ENST00000252599(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0050211"(procollagen galactosyltransferase activity)|go:"GO:1904028"(positive regulation of collagen fibril organization)|interpro:IPR002654(Glycosyl transferase, family 25)|interpro:IPR029044|mint:Q8NBJ5|reactome:R-HSA-1650814 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:nB7wFmsUKfA2+PrPaqw08fQpJRs9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9HCN8 intact:EBI-6179761 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q14554 intact:EBI-6179761 intact:EBI-953879|ensembl:ENSP00000323313|uniprotkb:D3DN95|uniprotkb:Q9BV43 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pdia5_human(display_long)|uniprotkb:Protein disulfide isomerase-related protein(gene name synonym)|uniprotkb:PDIA5(gene name)|psi-mi:PDIA5(display_short)|uniprotkb:PDIR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000065485(gene)|ensembl:ENST00000316218(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0022900"(electron transport chain)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041865|rcsb pdb:4I6X|reactome:R-HSA-381038|refseq:NP_006801.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:HhJNzAyAeysPEGdQL3Cz0piSjAM9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q13283 intact:EBI-6179761 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P68431 intact:EBI-6179761 intact:EBI-79722|ensembl:ENSP00000352252|ensembl:ENSP00000358160|ensembl:ENSP00000366999|ensembl:ENSP00000480826|ensembl:ENSP00000482271|ensembl:ENSP00000483283|ensembl:ENSP00000484095|ensembl:ENSP00000484638|ensembl:ENSP00000484658|ensembl:ENSP00000484841|ensembl:ENSP00000489282|intact:EBI-1560041|uniprotkb:A0PJT7|uniprotkb:P02295|uniprotkb:P02296|uniprotkb:P16106|uniprotkb:Q6ISV8|uniprotkb:Q6NWP8|uniprotkb:Q6NWP9|uniprotkb:Q6NXU4|uniprotkb:Q71DJ3|uniprotkb:Q93081|uniprotkb:A5PLR1 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:h31_human(display_long)|uniprotkb:H3FA(gene name synonym)|uniprotkb:H3FL(gene name synonym)|uniprotkb:H3FD(gene name synonym)|uniprotkb:H3FI(gene name synonym)|uniprotkb:H3FH(gene name synonym)|uniprotkb:H3FK(gene name synonym)|uniprotkb:H3FF(gene name synonym)|uniprotkb:H3FJ(gene name synonym)|uniprotkb:H3FB(gene name synonym)|uniprotkb:Histone H3/a(gene name synonym)|uniprotkb:Histone H3/b(gene name synonym)|uniprotkb:Histone H3/c(gene name synonym)|uniprotkb:Histone H3/d(gene name synonym)|uniprotkb:Histone H3/f(gene name synonym)|uniprotkb:Histone H3/h(gene name synonym)|uniprotkb:Histone H3/i(gene name synonym)|uniprotkb:Histone H3/j(gene name synonym)|uniprotkb:Histone H3/k(gene name synonym)|uniprotkb:Histone H3/l(gene name synonym)|uniprotkb:H3C1(gene name)|psi-mi:H3C1(display_short)|uniprotkb:HIST1H3A(gene name synonym)|uniprotkb:H3C2(gene name)|psi-mi:H3C2(display_short)|uniprotkb:HIST1H3B(gene name synonym)|uniprotkb:H3C3(gene name)|psi-mi:H3C3(display_short)|uniprotkb:H3FC HIST1H3C(gene name synonym)|uniprotkb:H3C4(gene name)|psi-mi:H3C4(display_short)|uniprotkb:HIST1H3D(gene name synonym)|uniprotkb:H3C6(gene name)|psi-mi:H3C6(display_short)|uniprotkb:HIST1H3E(gene name synonym)|uniprotkb:H3C7(gene name)|psi-mi:H3C7(display_short)|uniprotkb:HIST1H3F(gene name synonym)|uniprotkb:H3C8(gene name)|psi-mi:H3C8(display_short)|uniprotkb:HIST1H3G(gene name synonym)|uniprotkb:H3C10(gene name)|psi-mi:H3C10(display_short)|uniprotkb:HIST1H3H(gene name synonym)|uniprotkb:H3C11(gene name)|psi-mi:H3C11(display_short)|uniprotkb:HIST1H3I(gene name synonym)|uniprotkb:H3C12(gene name)|psi-mi:H3C12(display_short)|uniprotkb:HIST1H3J(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) rcsb pdb:4TN7|rcsb pdb:4U68|rcsb pdb:4UP0|rcsb pdb:4UY4|rcsb pdb:4X3K|rcsb pdb:4Y6L|rcsb pdb:4YHP|rcsb pdb:4YHZ|rcsb pdb:4YM5|rcsb pdb:4YM6|rcsb pdb:4Z0R|rcsb pdb:4Z2M|rcsb pdb:5AV5|rcsb pdb:5AV6|rcsb pdb:5AV8|rcsb pdb:5AV9|rcsb pdb:4QBS|rcsb pdb:5AVB|rcsb pdb:5AVC|rcsb pdb:5B24|rcsb pdb:5B2I|rcsb pdb:5B31|rcsb pdb:5C11|rcsb pdb:5C13|rcsb pdb:5C3I|rcsb pdb:5CPI|rcsb pdb:5CPJ|rcsb pdb:5CPK|rcsb pdb:5D6Y|rcsb pdb:5DAH|rcsb pdb:5FB0|rcsb pdb:5FB1|rcsb pdb:5FFV|rcsb pdb:5GH9|rcsb pdb:5GSE|rcsb pdb:5GSU|rcsb pdb:5GT0|rcsb pdb:5GT3|rcsb pdb:5GTC|rcsb pdb:5H6Q|rcsb pdb:5H6R|rcsb pdb:5HJB|rcsb pdb:5HJC|rcsb pdb:5HJD|rcsb pdb:5HYN|rcsb pdb:5IQL|rcsb pdb:5J3V|rcsb pdb:5J9S|rcsb pdb:5JHN|rcsb pdb:5JIN|rcsb pdb:5JIY|rcsb pdb:5JJ0|rcsb pdb:5B2J|rcsb pdb:5JRG|rcsb pdb:5KJH|rcsb pdb:5KJI|rcsb pdb:5KKL|rcsb pdb:5LUG|rcsb pdb:5M5G|rcsb pdb:5MR8|rcsb pdb:5NNC|rcsb pdb:5OY3|rcsb pdb:5SVX|rcsb pdb:5SVY|rcsb pdb:5SZB|rcsb pdb:5SZC|rcsb pdb:5T0K|rcsb pdb:5T0M|rcsb pdb:5T1G|rcsb pdb:5T1I|rcsb pdb:5T8R|rcsb pdb:5TBN|rcsb pdb:5TDR|rcsb pdb:5TDW|rcsb pdb:5U2J|rcsb pdb:5V21|rcsb pdb:5V22|rcsb pdb:5VA6|rcsb pdb:5VAB|rcsb pdb:5VGE|rcsb pdb:5VNB|rcsb pdb:5NND|rcsb pdb:5WLE|rcsb pdb:5WVO|rcsb pdb:5WXG|rcsb pdb:5WXH|rcsb pdb:5WYI|rcsb pdb:5X60|rcsb pdb:5XF3|rcsb pdb:5XF4|rcsb pdb:5XF5|rcsb pdb:5XFQ|rcsb pdb:5XFR|rcsb pdb:5XNV|rcsb pdb:5XTZ|rcsb pdb:5Y0C|rcsb pdb:5Y0D|rcsb pdb:5Y20|rcsb pdb:5Y2F|rcsb pdb:5Z23|rcsb pdb:5Z30|rcsb pdb:6AXJ|rcsb pdb:6AZE|rcsb pdb:6BHD|rcsb pdb:6BHE|rcsb pdb:6BHG|rcsb pdb:6BHH|rcsb pdb:6BHI|rcsb pdb:6D07|rcsb pdb:6D08|rcsb pdb:6E83|rcsb pdb:6E86|rcsb pdb:5WFC|rcsb pdb:6F6D|rcsb pdb:6HTS|rcsb pdb:6IEU|rcsb pdb:6IIS|rcsb pdb:6IIT|rcsb pdb:6IPU|rcsb pdb:6IQ4|rcsb pdb:6JOU|rcsb pdb:6JR0|rcsb pdb:6JR1|rcsb pdb:6JXD|rcsb pdb:6K1I|rcsb pdb:6K1J|rcsb pdb:6K1K|rcsb pdb:6KE9|rcsb pdb:6KVD|rcsb pdb:6L49|rcsb pdb:6L4A|rcsb pdb:6L9H|rcsb pdb:6L9Z|rcsb pdb:6LA2|rcsb pdb:6LA8|rcsb pdb:6LA9|rcsb pdb:6LAB|rcsb pdb:6LE9|rcsb pdb:6LER|rcsb pdb:6LS6|rcsb pdb:6LSD|rcsb pdb:6M3V|rcsb pdb:6M44|rcsb pdb:6M4D|rcsb pdb:6M4G|rcsb pdb:6M4H|rcsb pdb:6MIL|rcsb pdb:6MIM|rcsb pdb:6MIN|rcsb pdb:6MIO|rcsb pdb:6MIQ|rcsb pdb:6PA1|rcsb pdb:6PAG|rcsb pdb:6HKT|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R93|rcsb pdb:6R94|rcsb pdb:6T90|rcsb pdb:6T93|rcsb pdb:6UPK|rcsb pdb:6UPL|rcsb pdb:6USJ|rcsb pdb:6V2H|rcsb pdb:6V2K|rcsb pdb:6V3N|rcsb pdb:6V41|rcsb pdb:6V92|rcsb pdb:6VIL|rcsb pdb:6WAV|rcsb pdb:6WW4|rcsb pdb:6YIF|rcsb pdb:6YIH|rcsb pdb:6YOV|rcsb pdb:7BWD|rcsb pdb:7C0M|rcsb pdb:7CCQ|rcsb pdb:6R92|rcsb pdb:7CCR|rcsb pdb:7D1Z|rcsb pdb:7DBP|rcsb pdb:7K5X|rcsb pdb:7K5Y|rcsb pdb:7K60|rcsb pdb:7K61|rcsb pdb:7K63|rcsb pdb:7KLR|rcsb pdb:7LYC|reactome:R-HSA-1266695|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214842|reactome:R-HSA-3214847|reactome:R-HSA-3214858|ensembl:ENSG00000197153(gene)|ensembl:ENSG00000197409(gene)|ensembl:ENSG00000273983(gene)|ensembl:ENSG00000274750(gene)|ensembl:ENSG00000275379(gene)|ensembl:ENSG00000275714(gene)|ensembl:ENSG00000277775(gene)|ensembl:ENSG00000278828(gene)|ensembl:ENSG00000286522(gene)|ensembl:ENSG00000287080(gene)|ensembl:ENST00000356476(transcript)|ensembl:ENST00000359303(transcript)|ensembl:ENST00000369163(transcript)|ensembl:ENST00000612966(transcript)|ensembl:ENST00000613854(transcript)|ensembl:ENST00000614378(transcript)|ensembl:ENST00000614911(transcript)|ensembl:ENST00000616365(transcript)|ensembl:ENST00000618052(transcript)|ensembl:ENST00000621411(transcript)|ensembl:ENST00000634733(transcript)|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-3247509|reactome:R-HSA-9710421|go:"GO:0032200"(telomere organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000164(Histone H3)|interpro:IPR007125(Histone core)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|interpro:IPR009072(Histone-fold)|mint:P68431|rcsb pdb:1CS9|rcsb pdb:1CT6|rcsb pdb:1O9S|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|rcsb pdb:1Q3L|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|rcsb pdb:2B2T|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|rcsb pdb:2B2U|rcsb pdb:2B2V|rcsb pdb:2B2W|rcsb pdb:2C1J|rcsb pdb:2C1N|go:"GO:0016020"(membrane)|rcsb pdb:2CO0|rcsb pdb:2CV5|rcsb pdb:2FSA|rcsb pdb:2KWJ|rcsb pdb:2KWK|rcsb pdb:2L75|rcsb pdb:2LBM|rcsb pdb:2LGG|rcsb pdb:2M0O|reactome:R-HSA-983231|reactome:R-HSA-977225|rcsb pdb:2NDG|rcsb pdb:2OQ6|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2RI7|rcsb pdb:2RR4|rcsb pdb:2UXN|rcsb pdb:2V85|rcsb pdb:2V89|rcsb pdb:2VNF|rcsb pdb:2VPG|rcsb pdb:2X0L|rcsb pdb:3A1B|rcsb pdb:2NDF|rcsb pdb:3AFA|rcsb pdb:3AVR|rcsb pdb:3AYW|rcsb pdb:3AZE|rcsb pdb:3AZF|rcsb pdb:3AZG|rcsb pdb:3AZH|rcsb pdb:3AZI|rcsb pdb:3AZJ|rcsb pdb:3AZL|rcsb pdb:3AZM|rcsb pdb:3AZN|rcsb pdb:3B95|rcsb pdb:3FDT|rcsb pdb:3KMT|rcsb pdb:3KQI|rcsb pdb:3LQI|rcsb pdb:3LQJ|rcsb pdb:3MP1|rcsb pdb:3O34|rcsb pdb:3O35|rcsb pdb:3O37|rcsb pdb:3QJ6|rcsb pdb:3RIG|rcsb pdb:3RIY|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3U31|rcsb pdb:3U3D|rcsb pdb:3U4S|rcsb pdb:3U5N|rcsb pdb:3U5O|rcsb pdb:3AZK|rcsb pdb:3U5P|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UII|rcsb pdb:3UIK|rcsb pdb:3V43|rcsb pdb:3W96|rcsb pdb:3W97|rcsb pdb:3W98|rcsb pdb:3W99|rcsb pdb:3WA9|rcsb pdb:3WAA|rcsb pdb:3WKJ|rcsb pdb:3X1S|rcsb pdb:3X1T|rcsb pdb:3X1U|rcsb pdb:3X1V|rcsb pdb:3ZG6|rcsb pdb:3ZVY|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:4A7J|rcsb pdb:3UIG|rcsb pdb:4BD3|rcsb pdb:4C1Q|rcsb pdb:4F4U|rcsb pdb:4F56|rcsb pdb:4FWF|rcsb pdb:4HON|rcsb pdb:4I51|rcsb pdb:4L7X|rcsb pdb:4LK9|rcsb pdb:4LKA|rcsb pdb:4LLB|rcsb pdb:4LXL|rcsb pdb:4N4H|rcsb pdb:4QBQ|rcsb pdb:4QBR|refseq:NP_003520.1|refseq:NP_003521.2|refseq:NP_003522.1|refseq:NP_003523.1|refseq:NP_003524.1|refseq:NP_003525.1|refseq:NP_003526.1|refseq:NP_003527.1|refseq:NP_003528.1|refseq:NP_066298.1|dip:DIP-29371N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:ood0OohxZHuhsWZtO7U7GMc+LwM9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q9BZQ6 intact:EBI-6179761 intact:EBI-2556756|uniprotkb:B7ZLZ2|uniprotkb:Q9UFV7|uniprotkb:Q0VGM5|uniprotkb:B2RCH6|uniprotkb:Q9HCW1|uniprotkb:Q5TEZ0|uniprotkb:Q7L2Y5|ensembl:ENSP00000318147|intact:EBI-11137062 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:edem3_human(display_long)|uniprotkb:C1orf22(gene name synonym)|uniprotkb:EDEM3(gene name)|psi-mi:EDEM3(display_short)|uniprotkb:Alpha-1,2-mannosidase EDEM3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_079467.3|ensembl:ENSG00000116406(gene)|ensembl:ENST00000318130(transcript)|go:"GO:0004571"(mannosyl-oligosaccharide 1,2-alpha-mannosidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016020"(membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:1904382"(mannose trimming involved in glycoprotein ERAD pathway)|interpro:IPR001382(Glycoside hydrolase, family 47)|interpro:IPR003137(Protease-associated PA)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR036026|interpro:IPR037322|interpro:IPR044674|reactome:R-HSA-901032|refseq:NP_001306889.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:Y+n8Hhal53ri5I8jlKzXI6S8pk09606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q8NBJ7 intact:EBI-6179761 intact:EBI-723091|uniprotkb:Q14DW5|uniprotkb:Q53ZE3|uniprotkb:Q96BH2|uniprotkb:Q9BRN3|uniprotkb:Q9BWI1|uniprotkb:Q9Y405|ensembl:ENSP00000400922|uniprotkb:B4DU41|uniprotkb:B4DWQ0 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sumf2_human(display_long)|uniprotkb:SUMF2(gene name)|psi-mi:SUMF2(display_short)|uniprotkb:Sulfatase-modifying factor 2(gene name synonym)|uniprotkb:PSEC0171(orf name)|uniprotkb:UNQ1968/PRO4500(orf name)|uniprotkb:Paralog of formylglycine-generating enzyme(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001035934.2|refseq:NP_001035935.2|refseq:NP_001139805.1|refseq:NP_056226.2|refseq:NP_001123541.1|ensembl:ENSG00000129103(gene)|ensembl:ENST00000434526(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR005532(Sulphate-modifying factor-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR042095|rcsb pdb:1Y4J|reactome:R-HSA-1660662|reactome:R-HSA-1663150 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.99 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:l5K3nL4Cf/sygAOzoS2fcH4rmL09606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:P48741 intact:EBI-6179761 intact:EBI-877656|uniprotkb:P19790 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hsp77_human(display_long)|uniprotkb:Heat shock 70 kDa protein B(gene name synonym)|uniprotkb:HSPA7(gene name)|psi-mi:HSPA7(display_short)|uniprotkb:HSP70B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|reactome:R-HSA-3371453|interpro:IPR043129 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:ZXOhfWYdKdW1ek+VsKZyF/Zo84o9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038427 uniprotkb:Q92598 intact:EBI-6179761 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 psi-mi:p04578-pro_0000038427(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176374|imex:IM-17346-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:33|chain-seq-end:511 author-confidence:0.94 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2019/11/11 rogid:Ju2sEbpN5h9Gu+NdP1f1T772sIc11706 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 intact-crc:7E706E82CF346C65|rigid:y/UTNwetM3MOF9brkVrkR93tDfs false mutation:21-21,160-160,183-183,192-192,62-62,314-314,438-438("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P20701 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-961214|ensembl:ENSP00000349252|uniprotkb:O43746|uniprotkb:Q45H73|uniprotkb:Q9UBC8|intact:EBI-3962403|uniprotkb:Q96HB1 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ital_human(display_long)|uniprotkb:ITGAL(gene name)|psi-mi:ITGAL(display_short)|uniprotkb:CD11A(gene name synonym)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002200.2|ensembl:ENSG00000005844(gene)|ensembl:ENST00000356798(transcript)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1CQP|rcsb pdb:1DGQ|rcsb pdb:1IJ4|rcsb pdb:1LFA|rcsb pdb:1MJN|rcsb pdb:1MQ8|rcsb pdb:1MQ9|rcsb pdb:1MQA|rcsb pdb:1RD4|rcsb pdb:1T0P|rcsb pdb:1XDD|rcsb pdb:1XDG|rcsb pdb:1XUO|rcsb pdb:1ZON|rcsb pdb:1ZOO|rcsb pdb:1ZOP|rcsb pdb:2ICA|rcsb pdb:2K8O|rcsb pdb:2M3E|rcsb pdb:2O7N|rcsb pdb:3BN3|rcsb pdb:3BQM|rcsb pdb:3BQN|rcsb pdb:3E2M|rcsb pdb:3EOA|rcsb pdb:3EOB|rcsb pdb:3F74|rcsb pdb:3HI6|rcsb pdb:3F78|rcsb pdb:3M6F|rcsb pdb:3TCX|rcsb pdb:4IXD|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6798695|reactome:R-HSA-8949275|refseq:NP_001107852.1|dip:DIP-623N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:JeiBJZbkw8mtrE7WrFlkepPiAOY9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14696 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165891|ensembl:ENSP00000261758|ensembl:ENSP00000453430|ensembl:ENSP00000482455|uniprotkb:D3DW96|uniprotkb:Q969U1|uniprotkb:B4DW84 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:mesd_human(display_long)|uniprotkb:MESD(gene name)|psi-mi:MESD(display_short)|uniprotkb:KIAA0081(gene name synonym)|uniprotkb:LDLR chaperone MESD(gene name synonym)|uniprotkb:MESDC2(gene name synonym)|uniprotkb:MESDM(gene name synonym)|uniprotkb:Mesoderm development LRP chaperone MESD(gene name synonym)|uniprotkb:Mesoderm development candidate 2(gene name synonym)|uniprotkb:Mesoderm development protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-61(gene name synonym)|uniprotkb:UNQ1911/PRO4369(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000117899(gene)|ensembl:ENST00000261758(transcript)|ensembl:ENST00000619987(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|ensembl:ENST00000561312(transcript)|go:"GO:0006909"(phagocytosis)|go:"GO:0007498"(mesoderm development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR019330|mint:Q14696|refseq:NP_055969.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:PO/8DDUMQwmzmwLpGYdFJWIUdB09606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01733 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165888|ensembl:ENSP00000477916|ensembl:ENSP00000487964|uniprotkb:A0A5A7|uniprotkb:A0A0A6YYD5 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tvbl3_human(display_long)|uniprotkb:T-cell receptor beta chain V region YT35(gene name synonym)|uniprotkb:TCRBV12S3(gene name synonym)|uniprotkb:TRBV12-3(gene name)|psi-mi:TRBV12-3(display_short)|uniprotkb:TCRBV8S1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948|ensembl:ENSG00000274752(gene)|ensembl:ENSG00000282208(gene)|ensembl:ENST00000620569(transcript)|ensembl:ENST00000633292(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042287"(MHC protein binding)|go:"GO:0042605"(peptide antigen binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01733|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Q1iF+Ih5FyVl9ty4wDJUaAVh/V89606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q6DD88 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165882|ensembl:ENSP00000381844|uniprotkb:Q8N7W5|uniprotkb:Q9H8Q5|uniprotkb:Q9UFL1 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:atla3_human(display_long)|uniprotkb:ATL3(gene name)|psi-mi:ATL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|mint:Q6DD88|rcsb pdb:5VGR|rcsb pdb:6XJO|go:"GO:0007030"(Golgi organization)|ensembl:ENSG00000184743(gene)|ensembl:ENST00000398868(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001276977.1|refseq:NP_056274.3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9vgpZvUg5aFAZyNiZ2pdEPn/J7o9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96IV0 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165879|ensembl:ENSP00000280700|uniprotkb:B4DJE9|uniprotkb:Q59FB1|uniprotkb:Q6PJD8|uniprotkb:Q9BVR8|uniprotkb:Q9NR70 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ngly1_human(display_long)|uniprotkb:NGLY1(gene name)|psi-mi:NGLY1(display_short)|uniprotkb:N-glycanase 1(gene name synonym)|uniprotkb:PNG1(gene name synonym)|uniprotkb:"Peptide:N-glycanase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000151092(gene)|ensembl:ENST00000280700(transcript)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR006588(Protein of unknown function PAW)|interpro:IPR008979(Galactose-binding like)|interpro:IPR018997|interpro:IPR036339|interpro:IPR038680|interpro:IPR038765|mint:Q96IV0|rcsb pdb:2CCQ|rcsb pdb:2CM0|reactome:R-HSA-532668|refseq:NP_001138767.1|refseq:NP_060767.2|refseq:NP_001138765.1|refseq:NP_001138766.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:CujOKLkvqxGmWpFvJM3B894PHqc9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P43630 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165894|ensembl:ENSP00000479425|ensembl:ENSP00000479772|ensembl:ENSP00000325525|ensembl:ENSP00000477516|ensembl:ENSP00000477519|ensembl:ENSP00000478251|ensembl:ENSP00000479299|ensembl:ENSP00000479903|ensembl:ENSP00000481209|ensembl:ENSP00000481579|ensembl:ENSP00000481662|ensembl:ENSP00000482110|ensembl:ENSP00000482301|ensembl:ENSP00000482565|ensembl:ENSP00000491183|ensembl:ENSP00000491303|ensembl:ENSP00000491436|ensembl:ENSP00000492261|uniprotkb:Q13238|uniprotkb:Q14947|uniprotkb:Q14948|uniprotkb:Q92684|uniprotkb:Q95367|uniprotkb:Q95368|uniprotkb:Q95366 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ki3l2_human(display_long)|uniprotkb:KIR3DL2(gene name)|psi-mi:KIR3DL2(display_short)|uniprotkb:CD158 antigen-like family member K(gene name synonym)|uniprotkb:CD158K(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:NKAT4(gene name synonym)|uniprotkb:Natural killer-associated transcript 4(gene name synonym)|uniprotkb:p70 natural killer cell receptor clone CL-5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000240403(gene)|ensembl:ENSG00000274722(gene)|ensembl:ENSG00000275083(gene)|ensembl:ENSG00000275416(gene)|ensembl:ENSG00000275566(gene)|ensembl:ENSG00000275626(gene)|ensembl:ENSG00000276004(gene)|ensembl:ENSG00000276357(gene)|ensembl:ENSG00000276739(gene)|ensembl:ENSG00000277181(gene)|ensembl:ENSG00000278361(gene)|ensembl:ENSG00000278442(gene)|ensembl:ENSG00000278474(gene)|ensembl:ENSG00000278809(gene)|ensembl:ENSG00000283951(gene)|ensembl:ENSG00000283975(gene)|ensembl:ENSG00000284063(gene)|ensembl:ENSG00000284381(gene)|ensembl:ENST00000326321(transcript)|ensembl:ENST00000611608(transcript)|ensembl:ENST00000611628(transcript)|ensembl:ENST00000613610(transcript)|ensembl:ENST00000613612(transcript)|ensembl:ENST00000614753(transcript)|ensembl:ENST00000617354(transcript)|ensembl:ENST00000617666(transcript)|ensembl:ENST00000617957(transcript)|ensembl:ENST00000619683(transcript)|ensembl:ENST00000620817(transcript)|ensembl:ENST00000621155(transcript)|ensembl:ENST00000622024(transcript)|ensembl:ENST00000622453(transcript)|ensembl:ENST00000638330(transcript)|ensembl:ENST00000638891(transcript)|ensembl:ENST00000638970(transcript)|ensembl:ENST00000640782(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|refseq:NP_001229796.1|refseq:NP_006728.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:z6uiSVZQ/gMCPqiX5E6syx6t3jY9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9NWW5 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165897|ensembl:ENSP00000249806|uniprotkb:B4DDH6|uniprotkb:A8K560|uniprotkb:Q6IAB1|uniprotkb:Q96SR0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cln6_human(display_long)|uniprotkb:CLN6(gene name)|psi-mi:CLN6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000128973(gene)|ensembl:ENST00000249806(transcript)|go:"GO:0001573"(ganglioside metabolic process)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007601"(visual perception)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044265"(cellular macromolecule catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0120146"(sulfatide binding)|interpro:IPR029255|refseq:NP_060352.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:oX9lqo/LjQbBWTpBj1voRRmnOO89606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P14314 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P04843 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01130 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P16615 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14697 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O00264 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01850 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1034839|uniprotkb:A0A5B8|uniprotkb:A6NH51|uniprotkb:A0A0J9YYE9 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:trbc1_human(display_long)|uniprotkb:TRBC1(gene name)|psi-mi:TRBC1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:4L9L|rcsb pdb:4LCC|rcsb pdb:4LCW|rcsb pdb:4MNQ|rcsb pdb:3D3V|rcsb pdb:4NQC|rcsb pdb:4NQD|rcsb pdb:4NQE|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:4PRH|rcsb pdb:4PRI|rcsb pdb:4PRP|rcsb pdb:3D39|rcsb pdb:3HE6|rcsb pdb:3KPR|rcsb pdb:4GG6|rcsb pdb:4GG8|rcsb pdb:4L4V|rcsb pdb:2BNQ|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1FYT|rcsb pdb:1J8H|rcsb pdb:1KGC|rcsb pdb:1KTK|rcsb pdb:1MI5|rcsb pdb:1OGA|rcsb pdb:1YMM|rcsb pdb:1ZGL|rcsb pdb:2AK4|rcsb pdb:2AXH|rcsb pdb:2BNR|rcsb pdb:2BNU|rcsb pdb:2ESV|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GJ6|rcsb pdb:2IAL|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2NTS|rcsb pdb:2NW2|rcsb pdb:2NX5|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PO6|rcsb pdb:2PYE|rcsb pdb:2PYF|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLM|rcsb pdb:2VLR|rcsb pdb:2XN9|rcsb pdb:2XNA|rcsb pdb:3DX9|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:4ZDH|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|rcsb pdb:4G8E|rcsb pdb:4G8F|rcsb pdb:4IIQ|rcsb pdb:4JRX|rcsb pdb:4JRY|rcsb pdb:4MJI|rcsb pdb:4P46|rcsb pdb:4X6B|rcsb pdb:4X6C|rcsb pdb:4X6D|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFH|rcsb pdb:2CDE|rcsb pdb:2CDF|rcsb pdb:2CDG|rcsb pdb:3ARB|rcsb pdb:3ARD|rcsb pdb:3ARE|rcsb pdb:3ARF|rcsb pdb:3ARG|rcsb pdb:3O4L|rcsb pdb:1AO7|rcsb pdb:3HG1|rcsb pdb:3KPS|rcsb pdb:3TN0|rcsb pdb:4L4T|interpro:IPR036179 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:tLvWuE6FRB59QPlPL99jKQFkiuQ9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P61619 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q15392 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-5457558|uniprotkb:B7Z817|ensembl:ENSP00000360316|ensembl:ENSP00000416585|uniprotkb:D3DQ51|uniprotkb:Q9HBA8|intact:EBI-10964490 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:dhc24_human(display_long)|uniprotkb:DHCR24(gene name)|psi-mi:DHCR24(display_short)|uniprotkb:KIAA0018(gene name synonym)|uniprotkb:24-dehydrocholesterol reductase(gene name synonym)|uniprotkb:Diminuto/dwarf1 homolog(gene name synonym)|uniprotkb:Seladin-1(gene name synonym)|uniprotkb:3-beta-hydroxysterol Delta-24-reductase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000116133(gene)|ensembl:ENST00000371269(transcript)|ensembl:ENST00000436604(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016628"(oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0050614"(delta24-sterol reductase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061024"(membrane organization)|go:"GO:0071949"(FAD binding)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016166(FAD-binding, type 2)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR040165|go:"GO:0005737"(cytoplasm)|mint:Q15392|reactome:R-HSA-6807047|reactome:R-HSA-6807062|refseq:NP_055577.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:kg8bxZHxFFTUmvP9UQMeVFRNWQM9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9BXS5 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-541426|ensembl:ENSP00000291439|uniprotkb:Q4TTY5 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ap1m1_human(display_long)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:AP1M1(gene name)|psi-mi:AP1M1(display_short)|uniprotkb:CLTNM(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_115882.1|ensembl:ENSG00000072958(gene)|ensembl:ENST00000291439(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:Q9BXS5|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001123996.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:B6OVovdusOdmvB0D+RIyhRRga2Q9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P07384 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1542113|uniprotkb:Q2TTR0|uniprotkb:Q6DHV4|ensembl:ENSP00000279247|ensembl:ENSP00000431686|ensembl:ENSP00000431984|ensembl:ENSP00000434176|ensembl:ENSP00000435272 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:can1_human(display_long)|uniprotkb:CAPN1(gene name)|psi-mi:CAPN1(display_short)|uniprotkb:CANPL1(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 30 protein(gene name synonym)|uniprotkb:PIG30(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:XP_006718761.1|refseq:NP_001185797.1|refseq:NP_001185798.1|refseq:NP_005177.2|refseq:XP_011543594.1|ensembl:ENSG00000014216(gene)|ensembl:ENST00000279247(transcript)|ensembl:ENST00000524773(transcript)|ensembl:ENST00000527323(transcript)|ensembl:ENST00000533129(transcript)|ensembl:ENST00000533820(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097264"(self proteolysis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P07384|rcsb pdb:1ZCM|rcsb pdb:2ARY|reactome:R-HSA-1474228|reactome:R-HSA-6798695|reactome:R-HSA-6809371|reactome:R-HSA-8862803 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:hLf5vu04E7/yonXBb9VIZThbcxk9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9NYU2 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q99470 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O94901 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2796904|uniprotkb:B7WP53|uniprotkb:Q9UH98|uniprotkb:Q9HA14|uniprotkb:B7WNY4|uniprotkb:B3KMV7|uniprotkb:Q96CZ7|uniprotkb:B4DZF7|uniprotkb:E9PDU4|uniprotkb:A5PL20|uniprotkb:E9PF23|uniprotkb:F8WD13|ensembl:ENSP00000384015 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sun1_human(display_long)|uniprotkb:KIAA0810(gene name synonym)|uniprotkb:UNC84A(gene name synonym)|uniprotkb:Protein unc-84 homolog A(gene name synonym)|uniprotkb:Sad1/unc-84 protein-like 1(gene name synonym)|uniprotkb:SUN1(gene name)|psi-mi:SUN1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001165416.1|refseq:NP_001124437.1|refseq:NP_001165415.1|refseq:NP_001165417.1|refseq:NP_079430.3|ensembl:ENSG00000164828(gene)|ensembl:ENST00000401592(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|go:"GO:0070197"(meiotic attachment of telomere to nuclear envelope)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR018539|interpro:IPR032680|interpro:IPR040994|mint:O94901|rcsb pdb:6R15|rcsb pdb:6R16|rcsb pdb:6R2I|rcsb pdb:7E34|reactome:R-HSA-1221632 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:RJbLHCT6Gemrj6FLPEGesQcBGjY9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P27797 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q13112 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1052944|uniprotkb:Q99548|ensembl:ENSP00000315700 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:caf1b_human(display_long)|uniprotkb:Chromatin assembly factor I p60 subunit(gene name synonym)|uniprotkb:M-phase phosphoprotein 7(gene name synonym)|uniprotkb:CHAF1B(gene name)|psi-mi:CHAF1B(display_short)|uniprotkb:CAF1A(gene name synonym)|uniprotkb:CAF1P60(gene name synonym)|uniprotkb:MPHOSPH7(gene name synonym)|uniprotkb:MPP7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_005432.1|dip:DIP-29243N|ensembl:ENSG00000159259(gene)|ensembl:ENST00000314103(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR029129|interpro:IPR036322|mint:Q13112|refseq:XP_016883966.1|refseq:XP_016883967.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VVbW9mpUGYMRPxvlEk9FERHIsJs9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P51571 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1054539|uniprotkb:Q53XY1|uniprotkb:A8K378|ensembl:ENSP00000317331|ensembl:ENSP00000359103|ensembl:ENSP00000359104 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ssrd_human(display_long)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)|uniprotkb:SSR4(gene name)|psi-mi:SSR4(display_short)|uniprotkb:TRAPD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001191455.1|refseq:NP_006271.1|refseq:XP_011529488.1|refseq:XP_011529489.1|ensembl:ENSG00000180879(gene)|ensembl:ENST00000320857(transcript)|ensembl:ENST00000370086(transcript)|ensembl:ENST00000370087(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008855(Translocon-associated)|mint:P51571|reactome:R-HSA-1799339 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:2SNgZQH/jwi61UcuHUf7RYKZH589606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9Y287 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9Y282 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-781551|uniprotkb:Q6ZWP7|uniprotkb:Q9H276|uniprotkb:Q9P1L3|uniprotkb:Q5JWS3|ensembl:ENSP00000341358 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ergi3_human(display_long)|uniprotkb:Serologically defined breast cancer antigen NY-BR-84(gene name synonym)|uniprotkb:ERGIC3(gene name)|psi-mi:ERGIC3(display_short)|uniprotkb:C20orf47(gene name synonym)|uniprotkb:CGI-54(orf name)|uniprotkb:PRO0989(orf name)|uniprotkb:ERV46(gene name synonym)|uniprotkb:SDBCAG84(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_057050.1|refseq:NP_938408.1|ensembl:ENSG00000125991(gene)|ensembl:ENST00000348547(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|mint:Q9Y282 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:LllzE6k0eaM1uUJGjkieiPARw149606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P30101 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9H3P7 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1791792|uniprotkb:Q5VTJ0|uniprotkb:Q6P9F1|uniprotkb:Q8IZC5|uniprotkb:Q8N4D6|uniprotkb:Q9H6U3|uniprotkb:B2RB29|ensembl:ENSP00000355777 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:gcp60_human(display_long)|uniprotkb:GOCAP1(gene name synonym)|uniprotkb:GOLPH1(gene name synonym)|uniprotkb:ACBD3(gene name)|psi-mi:ACBD3(display_short)|uniprotkb:GCP60(gene name synonym)|uniprotkb:Acyl-CoA-binding domain-containing protein 3(gene name synonym)|uniprotkb:Golgi phosphoprotein 1(gene name synonym)|uniprotkb:Golgi complex-associated protein 1(gene name synonym)|uniprotkb:PBR- and PKA-associated protein 7(gene name synonym)|uniprotkb:Peripheral benzodiazepine receptor-associated protein PAP7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_073572.2|dip:DIP-40673N|ensembl:ENSG00000182827(gene)|ensembl:ENST00000366812(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR009038(GOLD)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR022408|interpro:IPR035984|interpro:IPR036598|mint:Q9H3P7|rcsb pdb:2N72|rcsb pdb:2N73|rcsb pdb:5LZ1|rcsb pdb:5LZ3|rcsb pdb:5LZ6|rcsb pdb:5TDQ|rcsb pdb:6HLN|rcsb pdb:6HLT|rcsb pdb:6HLV|rcsb pdb:6HLW|rcsb pdb:6HM8|rcsb pdb:6HMV|reactome:R-HSA-432722 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:jAaMXnoXG6RGj+lAgIYk1inXA6o9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P05107 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-300173|ensembl:ENSP00000303242|ensembl:ENSP00000347279|ensembl:ENSP00000380948|ensembl:ENSP00000380950|ensembl:ENSP00000380955|uniprotkb:Q16418|uniprotkb:B3KTS8|uniprotkb:Q53HS5|uniprotkb:Q9UD72|uniprotkb:D3DSM1 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:itb2_human(display_long)|uniprotkb:ITGB2(gene name)|psi-mi:ITGB2(display_short)|uniprotkb:CD18(gene name synonym)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:MFI7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0034689"(integrin alphaX-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043113"(receptor clustering)|ensembl:ENSG00000160255(gene)|ensembl:ENST00000302347(transcript)|ensembl:ENST00000355153(transcript)|ensembl:ENST00000397850(transcript)|ensembl:ENST00000397852(transcript)|ensembl:ENST00000397857(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:1990266"(neutrophil migration)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|go:"GO:0046872"(metal ion binding)|interpro:IPR036465|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|mint:P05107|rcsb pdb:1JX3|rcsb pdb:1L3Y|rcsb pdb:1YUK|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:2JF1|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2P26|rcsb pdb:2P28|rcsb pdb:2V7D|rcsb pdb:3K6S|rcsb pdb:3K71|rcsb pdb:3K72|go:"GO:0070821"(tertiary granule membrane)|rcsb pdb:4NEH|rcsb pdb:4NEN|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:5E6V|rcsb pdb:5E6W|rcsb pdb:5E6X|rcsb pdb:5ES4|rcsb pdb:5XR1|rcsb pdb:5ZAZ|reactome:R-HSA-166016|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695|refseq:NP_000202.3|refseq:NP_001120963.2|refseq:NP_001290167.1|dip:DIP-478N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:aaycm8Q/rmu01cs20dw399oJjFE9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P49257 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q07065 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBS4 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O14967 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-3907005|uniprotkb:D3DNY8|uniprotkb:B3KS90|uniprotkb:B4DXV8|ensembl:ENSP00000326699|ensembl:ENSP00000392782 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:clgn_human(display_long)|uniprotkb:CLGN(gene name)|psi-mi:CLGN(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001124147.1|refseq:NP_004353.1|ensembl:ENSG00000153132(gene)|ensembl:ENST00000325617(transcript)|ensembl:ENST00000414773(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:O14967 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Akb2XoiNjob34njC2erE11yg80w9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q13438 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-725454|intact:EBI-1174342|uniprotkb:A6NDD1|uniprotkb:A6NFR7|uniprotkb:A6NLB2|uniprotkb:A8K5Q9|uniprotkb:B4DPX1|uniprotkb:B4E1I6|uniprotkb:E7ENT8|uniprotkb:F8VUH2|uniprotkb:O00579|uniprotkb:Q6IBL2|uniprotkb:Q8IZ58|uniprotkb:Q9BW99|uniprotkb:B4DE28|ensembl:ENSP00000318165|uniprotkb:E7EW91|uniprotkb:G3XA88 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:os9_human(display_long)|uniprotkb:OS9(gene name)|psi-mi:OS9(display_short)|uniprotkb:Amplified in osteosarcoma 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006803.1|refseq:NP_001017956.1|refseq:NP_001017957.1|refseq:NP_001017958.1|refseq:NP_001248349.1|refseq:NP_001248350.1|refseq:NP_001248351.1|refseq:NP_001248352.1|ensembl:ENSG00000135506(gene)|ensembl:ENST00000315970(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0002020"(protease binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006605"(protein targeting)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|interpro:IPR044865|rcsb pdb:3AIH|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-37493N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Ntc3geE7th+rBeIp0MxuUuu/28Y9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBV2 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9HCN8 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96DZ1 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96EE3 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P07339 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2115097|uniprotkb:Q6IB57|ensembl:ENSP00000236671 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:catd_human(display_long)|uniprotkb:CTSD(gene name)|psi-mi:CTSD(display_short)|uniprotkb:CPSD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001900.1|dip:DIP-43906N|ensembl:ENSG00000117984(gene)|ensembl:ENST00000236671(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P07339|rcsb pdb:1LYA|rcsb pdb:1LYB|rcsb pdb:1LYW|rcsb pdb:4OBZ|rcsb pdb:4OC6|rcsb pdb:4OD9|reactome:R-HSA-1442490|reactome:R-HSA-2022377|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-9018519 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:M1qLQBlL2DSCZiAwIPee9Vza3dU9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q8TCT9 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176529|imex:IM-17346-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606 intact-crc:A928480AD6716B4B|rigid:Yw9t2XSgigZ+D9km43RGeCP+9Vc false tandem tag:c-c("MI:0677")|mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O94919 intact:EBI-6179711 intact:EBI-6163734|ensembl:ENSP00000278505|uniprotkb:Q8TAQ8|uniprotkb:Q6GQY5|uniprotkb:A8K6K8 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:endd1_human(display_long)|uniprotkb:ENDOD1(gene name)|psi-mi:ENDOD1(display_short)|uniprotkb:KIAA0830(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000149218(gene)|ensembl:ENST00000278505(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|interpro:IPR039015|reactome:R-HSA-114608|refseq:NP_055851.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Y1gEFK1zb6sij3QwLSrq9t4zQLU9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P61009 intact:EBI-6179711 intact:EBI-6166040|ensembl:ENSP00000427463|uniprotkb:P12280|uniprotkb:Q9H0S7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:spcs3_human(display_long)|uniprotkb:SPCS3(gene name)|psi-mi:SPCS3(display_short)|uniprotkb:Microsomal signal peptidase 22/23 kDa subunit(gene name synonym)|uniprotkb:SPC22(gene name synonym)|uniprotkb:UNQ1841/PRO3567(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000129128(gene)|ensembl:ENST00000503362(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR007653(Signal peptidase 22 kDa subunit)|mint:P61009|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085|refseq:NP_068747.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:IJjfzKRjeZefoy2znnC4XC6wgOU9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q6DD88 intact:EBI-6179711 intact:EBI-6165882|ensembl:ENSP00000381844|uniprotkb:Q8N7W5|uniprotkb:Q9H8Q5|uniprotkb:Q9UFL1 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:atla3_human(display_long)|uniprotkb:ATL3(gene name)|psi-mi:ATL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|mint:Q6DD88|rcsb pdb:5VGR|rcsb pdb:6XJO|go:"GO:0007030"(Golgi organization)|ensembl:ENSG00000184743(gene)|ensembl:ENST00000398868(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001276977.1|refseq:NP_056274.3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:9vgpZvUg5aFAZyNiZ2pdEPn/J7o9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9NYU2 intact:EBI-6179711 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q99623 intact:EBI-6179711 intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:h4pib54mBeQgOKCe/hib58LM26w9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96AJ9 intact:EBI-6179711 intact:EBI-3923262|uniprotkb:B4E137|uniprotkb:A2A307|ensembl:ENSP00000376792|uniprotkb:Q5W0D7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vti1a_human(display_long)|uniprotkb:VTI1A(gene name)|psi-mi:VTI1A(display_short)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_660207.2|ensembl:ENSG00000151532(gene)|ensembl:ENST00000393077(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|mint:Q96AJ9|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001305132.1|refseq:NP_001305134.1|refseq:XP_005269601.1|dip:DIP-44223N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:MZOfyoq6Oe9cFxPKa3ZxWTuPTrI9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O75955 intact:EBI-6179711 intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9P0L0 intact:EBI-6179711 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q92896 intact:EBI-6179711 intact:EBI-359610|uniprotkb:Q6P9D1|uniprotkb:Q13221|uniprotkb:D3DUJ7|uniprotkb:B7Z8Y4|ensembl:ENSP00000405984 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:gslg1_human(display_long)|uniprotkb:GLG1(gene name)|psi-mi:GLG1(display_short)|uniprotkb:CFR1(gene name synonym)|uniprotkb:ESL1(gene name synonym)|uniprotkb:MG160(gene name synonym)|uniprotkb:Golgi sialoglycoprotein MG-160(gene name synonym)|uniprotkb:E-selectin ligand 1(gene name synonym)|uniprotkb:Cysteine-rich fibroblast growth factor receptor(gene name synonym)|uniprotkb:CFR-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001139138.1|refseq:NP_001139139.1|refseq:NP_036333.2|ensembl:ENSG00000090863(gene)|ensembl:ENST00000422840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001893(Cysteine rich repeat)|interpro:IPR017873|interpro:IPR039728|reactome:R-HSA-202733|dip:DIP-27582N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:FTlNQD3o/wkPVjXkbB/G73BoBhw9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96R06 intact:EBI-6179711 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y5J9 intact:EBI-6179711 intact:EBI-1049085|uniprotkb:Q3KQS9|uniprotkb:Q9UN04|uniprotkb:B0YJA5|ensembl:ENSP00000422122 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tim8b_human(display_long)|uniprotkb:Deafness dystonia protein 2(gene name synonym)|uniprotkb:DDP-like protein(gene name synonym)|uniprotkb:TIM8B(gene name synonym)|uniprotkb:TIMM8B(gene name)|psi-mi:TIMM8B(display_short)|uniprotkb:DDP2(gene name synonym)|uniprotkb:DDPL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_036591.2|ensembl:ENSG00000150779(gene)|ensembl:ENST00000504148(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5J9|reactome:R-HSA-1268020 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:7DK/1BIkwyl9KMIgEFWqRhZn2ZE9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P48426 intact:EBI-6179711 intact:EBI-3924422|uniprotkb:Q5VUX3|uniprotkb:D3DRV1|uniprotkb:B0YJ66|uniprotkb:P53807|ensembl:ENSP00000365757|uniprotkb:B4DGX2 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pi42a_human(display_long)|uniprotkb:PIP4K2A(gene name)|psi-mi:PIP4K2A(display_short)|uniprotkb:PIP5K2(gene name synonym)|uniprotkb:PIP5K2A(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:PIP5KIII(gene name synonym)|uniprotkb:"PtdIns(4)P-5-kinase B isoform"(gene name synonym)|uniprotkb:"PtdIns(4)P-5-kinase C isoform"(gene name synonym)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:PI5P4KA(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005019.2|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|ensembl:ENST00000376573(transcript)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:P48426|rcsb pdb:2YBX|rcsb pdb:6OSP|rcsb pdb:6UX9|rcsb pdb:6YM3|rcsb pdb:6YM4|rcsb pdb:6YM5|rcsb pdb:7N6Z|rcsb pdb:7N7J|rcsb pdb:7N7K|rcsb pdb:7N7L|rcsb pdb:7N7M|rcsb pdb:7N7N|rcsb pdb:7N7O|reactome:R-HSA-1660499|reactome:R-HSA-6811555|reactome:R-HSA-6811558|reactome:R-HSA-8847453|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|ensembl:ENSG00000150867(gene)|refseq:NP_001316991.1|refseq:XP_016871819.1|refseq:XP_016871820.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Fmsp/H2ucCjs7wyiCgEqe9Y5UT49606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O60220 intact:EBI-6179711 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96DZ1 intact:EBI-6179711 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P14314 intact:EBI-6179711 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O15258 intact:EBI-6179711 intact:EBI-716910|uniprotkb:O95322|ensembl:ENSP00000464222|ensembl:ENSP00000475168 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rer1_human(display_long)|uniprotkb:RER1(gene name)|psi-mi:RER1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_008964.3|refseq:XP_011538844.1|refseq:XP_011538845.1|refseq:XP_006710369.1|ensembl:ENSG00000157916(gene)|ensembl:ENST00000488353(transcript)|ensembl:ENST00000605895(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009986"(cell surface)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR004932(Retrieval of early ER protein Rer1)|mint:O15258|refseq:XP_016855622.1|refseq:XP_016855623.1|refseq:XP_016855624.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:rLTZIWGawmaVck0uemR5/E9bFRk9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y5L4 intact:EBI-6179711 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9UBV2 intact:EBI-6179711 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O15260 intact:EBI-6179711 intact:EBI-1044848|uniprotkb:O60923|uniprotkb:Q9UNZ0|uniprotkb:Q9UNZ1|uniprotkb:Q5T8U6|ensembl:ENSP00000361057|ensembl:ENSP00000486049|uniprotkb:B7Z6A4 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:surf4_human(display_long)|uniprotkb:SURF4(gene name)|psi-mi:SURF4(display_short)|uniprotkb:SURF-4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_149351.1|ensembl:ENSG00000148248(gene)|ensembl:ENSG00000280951(gene)|ensembl:ENST00000629578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR002995(Surfeit locus 4)|mint:O15260|reactome:R-HSA-6798695|reactome:R-HSA-6811434|ensembl:ENST00000371989(transcript)|refseq:NP_001267718.1|refseq:NP_001267721.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:VEkKSEfWLmSZx209HLRfoMMTzsg9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P35232 intact:EBI-6179711 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q8N766 intact:EBI-6179711 intact:EBI-1044442|ensembl:ENSP00000420608|uniprotkb:Q14700|uniprotkb:Q63HL0|uniprotkb:Q63HL3|uniprotkb:Q8NBH8|uniprotkb:A8K6F3|uniprotkb:Q5TG62 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:emc1_human(display_long)|uniprotkb:EMC1(gene name)|psi-mi:EMC1(display_short)|uniprotkb:KIAA0090(gene name synonym)|uniprotkb:PSEC0263(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|ensembl:ENSG00000127463(gene)|ensembl:ENST00000477853(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072546"(EMC complex)|interpro:IPR002372(Pyrrolo-quinoline quinone)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR011678(Protein of unknown function DUF1620)|interpro:IPR026895|mint:Q8N766|rcsb pdb:6WW7|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|refseq:NP_055862.1|refseq:NP_001258356.1|refseq:NP_001258357.1|refseq:NP_001258358.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:ccxmkDoQwso1qb0UMHePqqRYcnU9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9P035 intact:EBI-6179711 intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P49257 intact:EBI-6179711 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P08134 intact:EBI-6179711 intact:EBI-747589|uniprotkb:Q6ICN3|uniprotkb:B3KSW1|ensembl:ENSP00000285735|ensembl:ENSP00000345236|ensembl:ENSP00000358646|ensembl:ENSP00000358647|ensembl:ENSP00000358651|ensembl:ENSP00000358652|ensembl:ENSP00000358656 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rhoc_human(display_long)|uniprotkb:Rho cDNA clone 9(gene name synonym)|uniprotkb:RHOC(gene name)|psi-mi:RHOC(display_short)|uniprotkb:ARH9(gene name synonym)|uniprotkb:ARHC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001036143.1|refseq:NP_001036144.1|refseq:NP_786886.1|ensembl:ENSG00000155366(gene)|ensembl:ENST00000285735(transcript)|ensembl:ENST00000339083(transcript)|ensembl:ENST00000369632(transcript)|ensembl:ENST00000369633(transcript)|ensembl:ENST00000369637(transcript)|ensembl:ENST00000369638(transcript)|ensembl:ENST00000369642(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032420"(stereocilium)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902766"(skeletal muscle satellite cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P08134|rcsb pdb:1Z2C|rcsb pdb:2GCN|rcsb pdb:2GCO|rcsb pdb:2GCP|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013106 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CPt/q5soDZILGfkngD41Y1U4eys9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O00264 intact:EBI-6179711 intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9NVV0 intact:EBI-6179711 intact:EBI-1055114|uniprotkb:Q5JR63|uniprotkb:Q5SVN5|uniprotkb:Q5SVN6|uniprotkb:Q5VTE2|uniprotkb:Q6IA97|ensembl:ENSP00000363824 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tm38b_human(display_long)|uniprotkb:Transmembrane protein 38B(gene name synonym)|uniprotkb:C9orf87(gene name synonym)|uniprotkb:TMEM38B(gene name)|psi-mi:TMEM38B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176669|imex:IM-17346-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_060582.1|ensembl:ENSG00000095209(gene)|ensembl:ENST00000374692(transcript)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0060348"(bone development)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR007866(Protein of unknown function DUF714) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:feIrxCWNpLCnAMaRwBsiKiz2y9w9606 intact-crc:ABCC270508EC4419|rigid:Kk3kHsZV4J/ojU8/5R4LEnabtl4 false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75475 uniprotkb:Q76353 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 intact:EBI-6248077 psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:q76353_9hiv1(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176762|imex:IM-17346-41 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910 go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS psi-mi:"MI:0007"(anti tag coimmunoprecipitation) author-confidence:0.79 comment:Extra met in N-terminal figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 intact-crc:1053D7BF1079FB75|rigid:DvdABEsbVB6DrBI5Or4jxjiJGbQ false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:O14734 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176813|imex:IM-17346-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606 intact-crc:9F5AFD94716F8CF1|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P30419 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-5280164|uniprotkb:A8K7C1|uniprotkb:Q9UE09|ensembl:ENSP00000258960|ensembl:ENSP00000468424|ensembl:ENSP00000504192 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:nmt1_human(display_long)|uniprotkb:NMT1(gene name)|psi-mi:NMT1(display_short)|uniprotkb:NMT(gene name synonym)|uniprotkb:"Myristoyl-CoA:protein N-myristoyltransferase 1"(gene name synonym)|uniprotkb:Peptide N-myristoyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176813|imex:IM-17346-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_066565.1|ensembl:ENSG00000136448(gene)|ensembl:ENST00000258960(transcript)|ensembl:ENST00000592782(transcript)|ensembl:ENST00000676828(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004379"(glycylpeptide N-tetradecanoyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0018008"(N-terminal peptidyl-glycine N-myristoylation)|go:"GO:0019107"(myristoyltransferase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0042180"(cellular ketone metabolic process)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR000903("Myristoyl-CoA:protein N-myristoyltransferase")|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR022676|interpro:IPR022677|interpro:IPR022678|rcsb pdb:1RXT|rcsb pdb:3IU1|rcsb pdb:3IU2|rcsb pdb:3IWE|rcsb pdb:3JTK|rcsb pdb:4C2Y|rcsb pdb:4C2Z|rcsb pdb:5MU6|rcsb pdb:5NPQ|rcsb pdb:5O6H|rcsb pdb:5O6J|rcsb pdb:5O9S|rcsb pdb:5O9T|rcsb pdb:5O9U|rcsb pdb:5O9V|rcsb pdb:5UUT|rcsb pdb:6EHJ|rcsb pdb:6F56|rcsb pdb:6FZ2|rcsb pdb:6FZ3|rcsb pdb:6FZ5|rcsb pdb:6PAV|rcsb pdb:6QRM|rcsb pdb:6SJZ|rcsb pdb:6SK2|rcsb pdb:6SK3|rcsb pdb:6SK8|rcsb pdb:6SKJ|reactome:R-HSA-162599|reactome:R-HSA-2514859|reactome:R-HSA-75108|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:eVkADRJp/cg4xIAw0ymeUZ+Vwyk9606 intact-crc:9F5AFD94716F8CF1|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:Q969X5 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-781527|uniprotkb:Q9H0L0|uniprotkb:Q9H2J2|uniprotkb:Q9ULN9|ensembl:ENSP00000377374 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:ergi1_human(display_long)|uniprotkb:ER-Golgi intermediate compartment 32 kDa protein(gene name synonym)|uniprotkb:ERGIC1(gene name)|psi-mi:ERGIC1(display_short)|uniprotkb:KIAA1181(gene name synonym)|uniprotkb:HT034(orf name)|uniprotkb:ERGIC32(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176813|imex:IM-17346-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:XP_006714955.1|refseq:NP_001026881.1|ensembl:ENSG00000113719(gene)|ensembl:ENST00000393784(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:UbuPGmvwVwrwg/LT5oAn9pLs5Hw9606 intact-crc:9F5AFD94716F8CF1|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:Q96A65 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176813|imex:IM-17346-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606 intact-crc:9F5AFD94716F8CF1|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9HD40 intact:EBI-6179719 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P49590 intact:EBI-6179719 intact:EBI-3909030|uniprotkb:B4DDY8|intact:EBI-10988212|ensembl:ENSP00000230771|ensembl:ENSP00000494296 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syhm_human(display_long)|uniprotkb:Histidyl-tRNA synthetase(gene name synonym)|uniprotkb:HARS2(gene name)|psi-mi:HARS2(display_short)|uniprotkb:HARSL(gene name synonym)|uniprotkb:HARSR(gene name synonym)|uniprotkb:HO3(gene name synonym)|uniprotkb:Histidine--tRNA ligase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_036340.1|refseq:NP_001265660.1|refseq:NP_001265661.1|ensembl:ENSG00000112855(gene)|ensembl:ENST00000230771(transcript)|ensembl:ENST00000645749(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004821"(histidine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006427"(histidyl-tRNA aminoacylation)|go:"GO:0042802"(identical protein binding)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004516(Histidyl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR015807(Histidyl-tRNA synthetase, class IIa, subgroup)|interpro:IPR033656|interpro:IPR036621|interpro:IPR041715|reactome:R-HSA-379726|go:"GO:0006412"(translation)|dip:DIP-59626N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:pp4g+OJKxW3va88iXtfIAnGXMKw9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P14868 intact:EBI-6179719 intact:EBI-358730|uniprotkb:Q2TNI3|uniprotkb:Q32Q69|uniprotkb:Q53HV4|uniprotkb:Q53YC5|uniprotkb:Q9BW52|uniprotkb:Q68CR9|uniprotkb:A8K3J2|uniprotkb:D3DP77|ensembl:ENSP00000264161 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sydc_human(display_long)|uniprotkb:DARS1(gene name)|psi-mi:DARS1(display_short)|uniprotkb:Aspartyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 40 protein(gene name synonym)|uniprotkb:DARS(gene name synonym)|uniprotkb:PIG40(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001340.2|refseq:NP_001280241.1|ensembl:ENSG00000115866(gene)|ensembl:ENST00000264161(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004815"(aspartate-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006422"(aspartyl-tRNA aminoacylation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0045202"(synapse)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004523(Aspartyl-tRNA synthetase, class IIb, archea/euk type)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:P14868|rcsb pdb:4J15|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:Yzpil/THkSHGR/ixVyQbV3RZz/E9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:O43324 intact:EBI-6179719 intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9P2J5 intact:EBI-6179719 intact:EBI-356077|uniprotkb:Q9NSE1|uniprotkb:A2RRR4|uniprotkb:B4DJ10|uniprotkb:Q2TU79|uniprotkb:A7E266|ensembl:ENSP00000377954 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sylc_human(display_long)|uniprotkb:LARS1(gene name)|psi-mi:LARS1(display_short)|uniprotkb:KIAA1352(gene name synonym)|uniprotkb:LARS(gene name synonym)|uniprotkb:Leucyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_064502.9|refseq:NP_001304893.1|refseq:NP_001304894.1|refseq:NP_057544.2|refseq:XP_011535958.1|ensembl:ENSG00000133706(gene)|ensembl:ENST00000394434(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004819"(glutamine-tRNA ligase activity)|go:"GO:0004823"(leucine-tRNA ligase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006425"(glutaminyl-tRNA aminoacylation)|go:"GO:0006429"(leucyl-tRNA aminoacylation)|go:"GO:0008361"(regulation of cell size)|go:"GO:0012505"(endomembrane system)|go:"GO:0016604"(nuclear body)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071233"(cellular response to leucine)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR004493(Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|mint:Q9P2J5|rcsb pdb:2WFD|rcsb pdb:6KID|rcsb pdb:6KIE|rcsb pdb:6KQY|rcsb pdb:6KR7|rcsb pdb:6LPF|rcsb pdb:6LR6|reactome:R-HSA-2408522|reactome:R-HSA-379716 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:nlK4kRCik2LLC3VNl0sryrLLnqA9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q9NTK5 intact:EBI-6179719 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04591-PRO_0000038593 uniprotkb:P07814 intact:EBI-6179719 intact:EBI-355315|uniprotkb:Q5H9S5|uniprotkb:Q6PD57|uniprotkb:Q86X73|uniprotkb:A0AVA9|uniprotkb:Q05BP6|uniprotkb:Q05DF8|uniprotkb:Q5DSM1|ensembl:ENSP00000355890|uniprotkb:B9EGH3 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:syep_human(display_long)|uniprotkb:EPRS1(gene name)|psi-mi:EPRS1(display_short)|uniprotkb:Bifunctional aminoacyl-tRNA synthetase(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 32 protein(gene name synonym)|uniprotkb:EPRS(gene name synonym)|uniprotkb:GLNS(gene name synonym)|uniprotkb:Glutamatyl-prolyl-tRNA synthetase(gene name synonym)|uniprotkb:PARS(gene name synonym)|uniprotkb:QARS(gene name synonym)|uniprotkb:QPRS(gene name synonym)|uniprotkb:PIG32(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176777|imex:IM-17346-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_004437.2|ensembl:ENSG00000136628(gene)|ensembl:ENST00000366923(transcript)|go:"GO:0004818"(glutamate-tRNA ligase activity)|go:"GO:0004827"(proline-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006424"(glutamyl-tRNA aminoacylation)|go:"GO:0006433"(prolyl-tRNA aminoacylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0140212"(regulation of long-chain fatty acid import into cell)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000738(WHEP-TRS)|interpro:IPR000924(Glutamyl/glutaminyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR004154(Anticodon-binding)|interpro:IPR004499(Prolyl-tRNA synthetase, class IIa, prokaryotic-type)|interpro:IPR004526(Glutamyl-tRNA synthetase, class Ic, archaeal/eukaryotic cytosolic)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR009068(S15/NS1, RNA-binding)|interpro:IPR011035(Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR016061(Prolyl-tRNA synthetase, class II, C-terminal)|interpro:IPR017449(Prolyl-tRNA synthetase, class II)|interpro:IPR020056|interpro:IPR020058|interpro:IPR020059|interpro:IPR033721|interpro:IPR036282|interpro:IPR036621|mint:P07814|rcsb pdb:1FYJ|rcsb pdb:4HVC|rcsb pdb:4K86|rcsb pdb:4K87|rcsb pdb:4K88|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5BMU|rcsb pdb:5V58|rcsb pdb:5VAD|rcsb pdb:5Y6L|rcsb pdb:6IY6|reactome:R-HSA-2408522|reactome:R-HSA-379716|reactome:R-HSA-6782315|dip:DIP-40825N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:67nL6JkhNTSttOucQt3mLRQZeLY9606 intact-crc:8BCE7267FAB7D625|rigid:PbLg0sAD4BTbSV/BvwJ3BnmS0xA false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P50213 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9P2R7 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q14152 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P31350 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2339245|uniprotkb:B2R9B5|uniprotkb:Q5WRU7|uniprotkb:J3KP43|intact:EBI-10973436|ensembl:ENSP00000302955|ensembl:ENSP00000493399 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:rir2_human(display_long)|uniprotkb:RRM2(gene name)|psi-mi:RRM2(display_short)|uniprotkb:RR2(gene name synonym)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase small chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001025.1|refseq:NP_001159403.1|dip:DIP-24232N|ensembl:ENSG00000171848(gene)|ensembl:ENST00000304567(transcript)|ensembl:ENST00000641198(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:2UW2|rcsb pdb:3OLJ|rcsb pdb:3VPM|rcsb pdb:3VPN|rcsb pdb:3VPO|reactome:R-HSA-499943|reactome:R-HSA-69205|reactome:R-HSA-8953750 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:vkkD9wGSPnsXX89dIQ53fhLD7uI9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q15084 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:411bo7TdfeCtMvUqyBb7bofi5To9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y265 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353675|uniprotkb:P82276|uniprotkb:Q1KMR0|uniprotkb:Q53HK5|uniprotkb:Q53HL7|uniprotkb:Q53Y27|uniprotkb:Q9BSX9|uniprotkb:B2R5S0|ensembl:ENSP00000318297|ensembl:ENSP00000494621 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ruvb1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short)|uniprotkb:NMP238(gene name synonym)|uniprotkb:TIP49(gene name synonym)|uniprotkb:TIP49A(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:Nuclear matrix protein 238(gene name synonym)|uniprotkb:54 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80H(gene name synonym)|uniprotkb:TIP60-associated protein 54-alpha(gene name synonym)|uniprotkb:INO80 complex subunit H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003698.1|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9Y265|rcsb pdb:2C9O|rcsb pdb:2XSZ|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-606279|ensembl:ENSG00000175792(gene)|ensembl:ENSG00000284901(gene)|ensembl:ENST00000322623(transcript)|ensembl:ENST00000643444(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001306013.1|dip:DIP-29937N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:+FA/xQTUldQoWGRgad9U8vZpTHw9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UBQ5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15371 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9BRX2 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1043580|uniprotkb:Q9GZS6|uniprotkb:Q9Y306|ensembl:ENSP00000274311 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pelo_human(display_long)|uniprotkb:PELO(gene name)|psi-mi:PELO(display_short)|uniprotkb:CGI-17(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000152684(gene)|ensembl:ENST00000274311(transcript)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007049"(cell cycle)|go:"GO:0007492"(endoderm development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|mint:Q9BRX2|rcsb pdb:1X52|rcsb pdb:5EO3|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|refseq:NP_057030.3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:EZIi8JN2tu0u4oH06fOus3LKjoo9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P60228 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P33991 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y266 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q8N163 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P07858 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O75475 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1801773|uniprotkb:O00256|uniprotkb:O95368|uniprotkb:Q6P391|uniprotkb:Q86YB9|uniprotkb:Q9NZI3|uniprotkb:Q9UER6|uniprotkb:D3DRI9|ensembl:ENSP00000370109|ensembl:ENSP00000370114 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:psip1_human(display_long)|uniprotkb:PSIP1(gene name)|psi-mi:PSIP1(display_short)|uniprotkb:DFS70(gene name synonym)|uniprotkb:LEDGF(gene name synonym)|uniprotkb:PSIP2(gene name synonym)|uniprotkb:Lens epithelium-derived growth factor(gene name synonym)|uniprotkb:Transcriptional coactivator p75/p52(gene name synonym)|uniprotkb:Dense fine speckles 70 kDa protein(gene name synonym)|uniprotkb:CLL-associated antigen KW-7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001304827.1|refseq:NP_001304829.1|refseq:NP_001121689.1|refseq:NP_066967.3|refseq:NP_150091.2|dip:DIP-46656N|ensembl:ENSG00000164985(gene)|ensembl:ENST00000380733(transcript)|ensembl:ENST00000380738(transcript)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009408"(response to heat)|go:"GO:0034399"(nuclear periphery)|go:"GO:0035327"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000313(PWWP)|interpro:IPR021567|interpro:IPR035441|interpro:IPR035496|interpro:IPR036218|mint:O75475|rcsb pdb:1Z9E|rcsb pdb:2B4J|rcsb pdb:2M16|rcsb pdb:2MSR|rcsb pdb:2MTN|rcsb pdb:2N3A|rcsb pdb:3F9K|rcsb pdb:3HPG|rcsb pdb:3HPH|rcsb pdb:3U88|rcsb pdb:3ZEH|rcsb pdb:4FU6|rcsb pdb:5N88|rcsb pdb:5OYM|rcsb pdb:5YI9|rcsb pdb:6EMO|rcsb pdb:6EMP|rcsb pdb:6EMQ|rcsb pdb:6EMR|rcsb pdb:6S01|rcsb pdb:6TRJ|rcsb pdb:6TVM|rcsb pdb:6Z2Y|reactome:R-HSA-162592|reactome:R-HSA-164843|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:MRtOw4kH/FxVku25dO5RQiNTjDA9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q14566 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P33993 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y262 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q99613 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P62993 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P32121 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q5T4S7 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1995940|intact:EBI-1059327|uniprotkb:A8MPT2|uniprotkb:A8MQ33|uniprotkb:A8MQB1|uniprotkb:O60646|uniprotkb:O75050|uniprotkb:Q4QRK5|uniprotkb:Q5T4S8|uniprotkb:Q5T4S9|uniprotkb:Q5TBN8|uniprotkb:Q5TBP2|uniprotkb:Q6DKH8|uniprotkb:Q6P4A4|uniprotkb:Q7L8P7|uniprotkb:Q8IXJ4|uniprotkb:Q8TDN5|uniprotkb:Q8WV67|uniprotkb:Q9HA46|uniprotkb:Q9P2N9|uniprotkb:Q9UG82|ensembl:ENSP00000364403 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ubr4_human(display_long)|uniprotkb:UBR4(gene name)|psi-mi:UBR4(display_short)|uniprotkb:KIAA0462(gene name synonym)|uniprotkb:KIAA1307(gene name synonym)|uniprotkb:RBAF600(gene name synonym)|uniprotkb:ZUBR1(gene name synonym)|uniprotkb:N-recognin-4(gene name synonym)|uniprotkb:Zinc finger UBR1-type protein 1(gene name synonym)|uniprotkb:Retinoblastoma-associated factor of 600 kDa(gene name synonym)|uniprotkb:600 kDa retinoblastoma protein-associated factor(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_065816.2|ensembl:ENST00000375218|ensembl:ENSP00000364403|ensembl:ENSP00000364366|ensembl:ENSG00000127481(gene)|ensembl:ENST00000375254(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025704|interpro:IPR036322|mint:Q5T4S7|reactome:R-HSA-6798695|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:8Iown8oj965YAir+95+3om5+1YM9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9UJX6 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-396211|uniprotkb:Q5VSG1|uniprotkb:Q96DG5|uniprotkb:Q96GG4|uniprotkb:Q9P2E1|intact:EBI-28984882|ensembl:ENSP00000314004 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:anc2_human(display_long)|uniprotkb:ANAPC2(gene name)|psi-mi:ANAPC2(display_short)|uniprotkb:APC2(gene name synonym)|uniprotkb:KIAA1406(gene name synonym)|uniprotkb:Cyclosome subunit 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_037498.1|ensembl:ENSP00000314004|dip:DIP-32957N|ensembl:ENSG00000176248(gene)|ensembl:ENST00000323927(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090129"(positive regulation of synapse maturation)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR014786(Anaphase promoting complex subunit 2)|interpro:IPR016158(Cullin homology)|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|interpro:IPR044554|mint:Q9UJX6|rcsb pdb:4UI9|rcsb pdb:4YII|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6NXK|rcsb pdb:6OB1|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:PVV9qYjevihqygZjLzBflQ0Ob409606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15372 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9H4L5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O00303 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P22830 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q2T9J0 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2510623|ensembl:ENSP00000287078|uniprotkb:Q8N6H2|uniprotkb:Q5SQU1|uniprotkb:Q96AR5|uniprotkb:Q5SQT4 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:tysd1_human(display_long)|uniprotkb:TYSND1(gene name)|psi-mi:TYSND1(display_short)|uniprotkb:Trypsin domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176854|imex:IM-17346-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000156521(gene)|ensembl:ENST00000287078(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0042802"(identical protein binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017345(Peptidase S1B, Tysnd1)|interpro:IPR039245|reactome:R-HSA-9033241|reactome:R-HSA-9033500|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001035363.1|refseq:NP_775826.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:nfBCzADhPAnpbY6GasKVCOaZjjs9606 intact-crc:A29BE0E137B8F316|rigid:nFWwhZxItAtyWHnCHF0R3hTtzCE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118")|sufficient binding region:500-1447("MI:0442") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q92805 intact:EBI-6248094 intact:EBI-6164177|ensembl:ENSP00000362656|uniprotkb:Q5T164|uniprotkb:Q8IYZ9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:goga1_human(display_long)|uniprotkb:GOLGA1(gene name)|psi-mi:GOLGA1(display_short)|uniprotkb:Golgin-97(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000136935(gene)|ensembl:ENST00000373555(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|refseq:NP_002068.1|refseq:XP_006717125.1|refseq:XP_006717126.1|refseq:XP_005251986.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:5SRVVvNxZ7PikOK9zV4HypxK8i49606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9BTY7 intact:EBI-6248094 intact:EBI-6166333|ensembl:ENSP00000321320|intact:EBI-9393869|uniprotkb:P0CB43 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:hgh1_human(display_long)|uniprotkb:HGH1(gene name)|psi-mi:HGH1(display_short)|uniprotkb:C8orf30A(gene name synonym)|uniprotkb:C8orf30B(gene name synonym)|uniprotkb:FAM203A(gene name synonym)|uniprotkb:FAM203B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENST00000347708(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717|ensembl:ENSG00000235173(gene)|refseq:NP_057542.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:SbrzuW0fibvIYEwFfaLXCrMBmxw9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q07864 intact:EBI-6248094 intact:EBI-348526|uniprotkb:Q13533|intact:EBI-28987244|ensembl:ENSP00000322570|uniprotkb:Q86VH9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe1_human(display_long)|uniprotkb:POLE(gene name)|psi-mi:POLE(display_short)|uniprotkb:POLE1(gene name synonym)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006222.2|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0048568"(embryonic organ development)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:5VBN|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962|go:"GO:0008270"(zinc ion binding)|ensembl:ENSG00000177084(gene)|ensembl:ENST00000320574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|ensembl:ENSP00000322570|dip:DIP-24243N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:oPDFCAO2AeDB4UjbeBvo8DPi+ow9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P32121 intact:EBI-6248094 intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q12874 intact:EBI-6248094 intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:fNjNguUOXqApr46rOAEpTs2geqY9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8NFG4 intact:EBI-6248094 intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q86X55 intact:EBI-6248094 intact:EBI-2339854|uniprotkb:A6NN38|ensembl:ENSP00000325690 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:carm1_human(display_long)|uniprotkb:CARM1(gene name)|psi-mi:CARM1(display_short)|uniprotkb:PRMT4(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_954592.1|refseq:XP_005259765.1|dip:DIP-44071N|ensembl:ENSG00000142453(gene)|ensembl:ENST00000327064(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q86X55|rcsb pdb:2Y1W|rcsb pdb:2Y1X|rcsb pdb:4IKP|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5DX1|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5DXJ|rcsb pdb:5U4X|rcsb pdb:6ARJ|rcsb pdb:6ARV|rcsb pdb:6D2L|rcsb pdb:6DVR|rcsb pdb:6IZQ|rcsb pdb:6S70|rcsb pdb:6S71|rcsb pdb:6S74|rcsb pdb:6S77|rcsb pdb:6S79|rcsb pdb:6S7A|rcsb pdb:6S7B|rcsb pdb:6S7C|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-6804114|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|go:"GO:0051591"(response to cAMP) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:1x1bUjqcA/ZpmrSsSM545ReYH2A9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TF40 intact:EBI-6248094 intact:EBI-2946919|ensembl:ENSP00000421985|uniprotkb:Q9BUT0|uniprotkb:Q86T47|uniprotkb:D6RJH5 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:fnip1_human(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q8TF40|reactome:R-HSA-9639288|go:"GO:0032008"(positive regulation of TOR signaling)|refseq:NP_001008738.2|refseq:NP_588613.2|refseq:NP_001333042.1|dip:DIP-57169N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q14152 intact:EBI-6248094 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q86US8 intact:EBI-6248094 intact:EBI-3232100|ensembl:ENSP00000263073|uniprotkb:O94837|uniprotkb:Q9UF60|uniprotkb:Q86VH6|uniprotkb:B7Z874 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:est1a_human(display_long)|uniprotkb:SMG6(gene name)|psi-mi:SMG6(display_short)|uniprotkb:C17orf31(gene name synonym)|uniprotkb:EST1A(gene name synonym)|uniprotkb:KIAA0732(gene name synonym)|uniprotkb:EST1-like protein A(gene name synonym)|uniprotkb:Ever shorter telomeres 1A(gene name synonym)|uniprotkb:Smg-6 homolog(gene name synonym)|uniprotkb:Telomerase subunit EST1A(gene name synonym)|uniprotkb:hSmg5/7a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENST00000263073(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0035303"(regulation of dephosphorylation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051972"(regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018834|interpro:IPR019458|interpro:IPR029060|mint:Q86US8|rcsb pdb:2DOK|rcsb pdb:2HWW|rcsb pdb:2HWX|rcsb pdb:4UM2|reactome:R-HSA-975957|ensembl:ENSG00000070366(gene)|refseq:XP_011522071.1|refseq:XP_011522077.1|refseq:NP_060045.4|refseq:NP_001243756.1|refseq:NP_001243757.1|refseq:NP_001269255.1|refseq:XP_005256626.1|refseq:XP_005256628.1|refseq:XP_016879888.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:UoAA9ikMFv3EHZZozUAOkWWPrRM9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P33991 intact:EBI-6248094 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9HBG6 intact:EBI-6248094 intact:EBI-2805994|uniprotkb:B3KW53|uniprotkb:B4DEY9|uniprotkb:B4DPW7|uniprotkb:E7EQF4|uniprotkb:E9PDG2|uniprotkb:E9PDX2|uniprotkb:H7C3C0|uniprotkb:Q8TC06|uniprotkb:Q9NV68|uniprotkb:Q9UF80|uniprotkb:Q9HAT9|uniprotkb:Q53G36|ensembl:ENSP00000324005|uniprotkb:Q9BTB9|uniprotkb:Q9BTY4|uniprotkb:G3XAB1|uniprotkb:Q9HBG5 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:if122_human(display_long)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001267475.1|refseq:NP_060732.2|refseq:NP_443711.2|refseq:NP_443715.1|ensembl:ENST00000348417(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030991"(intraciliary transport particle A)|ensembl:ENSG00000163913(gene)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039857|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_443716.1|refseq:NP_001267470.1|refseq:NP_001267474.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+CItPDBES/UTyqgLedVcoHfVCcM9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99613 intact:EBI-6248094 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8N163 intact:EBI-6248094 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UGP4 intact:EBI-6248094 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99996 intact:EBI-6248094 intact:EBI-1048311|uniprotkb:O14869|uniprotkb:O43355|uniprotkb:O94895|uniprotkb:Q75N20|uniprotkb:Q9UQH3|uniprotkb:Q9UQQ4|uniprotkb:Q9Y6B8|uniprotkb:A4D1F0|uniprotkb:Q9Y6Y2|uniprotkb:A4D1F2|uniprotkb:A4D1F4|ensembl:ENSP00000348573 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:akap9_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)|uniprotkb:A-kinase anchor protein 450 kDa(gene name synonym)|uniprotkb:A-kinase anchor protein 350 kDa(gene name synonym)|uniprotkb:AKAP 120-like protein(gene name synonym)|uniprotkb:Protein hyperion(gene name synonym)|uniprotkb:Protein yotiao(gene name synonym)|uniprotkb:Centrosome- and Golgi-localized PKN-associated protein(gene name synonym)|uniprotkb:AKAP9(gene name)|psi-mi:AKAP9(display_short)|uniprotkb:AKAP350(gene name synonym)|uniprotkb:AKAP450(gene name synonym)|uniprotkb:KIAA0803(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_005742.4|refseq:NP_671714.1|ensembl:ENSG00000127914(gene)|ensembl:ENST00000356239(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044307"(dendritic branch)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR005539(ELK)|interpro:IPR019528|interpro:IPR028745|mint:Q99996|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5576890|reactome:R-HSA-5576893|reactome:R-HSA-5620912|reactome:R-HSA-6802952|reactome:R-HSA-8854518|ensembl:ENSP00000348573|ensembl:ENST00000680766|ensembl:ENSP00000505204|dip:DIP-29942N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:LQUNbTHUgEsjayFEZvczC4e90Nw9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NRF9 intact:EBI-6248094 intact:EBI-744901|uniprotkb:Q5W0U1|uniprotkb:Q8N758|uniprotkb:Q8NCE5|uniprotkb:Q9NR32|ensembl:ENSP00000363284|ensembl:ENSP00000363286 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe3_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p17(gene name synonym)|uniprotkb:Chromatin accessibility complex 17 kDa protein(gene name synonym)|uniprotkb:Arsenic-transactivated protein(gene name synonym)|uniprotkb:POLE3(gene name)|psi-mi:POLE3(display_short)|uniprotkb:CHRAC17(gene name synonym)|uniprotkb:DNA polymerase II subunit 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001265184.1|refseq:NP_059139.3|ensembl:ENSG00000148229(gene)|ensembl:ENST00000374169(transcript)|ensembl:ENST00000374171(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:eTI1XsrypxKqml09tm4GAImoZgI9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H8Y5 intact:EBI-6248094 intact:EBI-724848|uniprotkb:Q9NVZ4|intact:EBI-28979360|ensembl:ENSP00000321617|ensembl:ENSP00000386337 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:ankz1_human(display_long)|uniprotkb:Zinc finger protein 744(gene name synonym)|uniprotkb:ANKZF1(gene name)|psi-mi:ANKZF1(display_short)|uniprotkb:ZNF744(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001035869.1|refseq:NP_060559.2|ensembl:ENSP00000321617|ensembl:ENSP00000386337|ensembl:ENSG00000163516(gene)|ensembl:ENST00000323348(transcript)|ensembl:ENST00000410034(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR002110(Ankyrin)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036770|interpro:IPR041175|interpro:IPR041540 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.74 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ddIMBu8TTSoqw3EFEPgqx+F0BHA9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O60232 intact:EBI-6248094 intact:EBI-741415|ensembl:ENSP00000312318 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:znrd2_human(display_long)|uniprotkb:ZNRD2(gene name)|psi-mi:ZNRD2(display_short)|uniprotkb:Autoantigen p27(gene name synonym)|uniprotkb:SSSCA1(gene name synonym)|uniprotkb:Sjoegren syndrome/scleroderma autoantigen 1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006387.1|ensembl:ENSG00000173465(gene)|ensembl:ENST00000309328(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0051301"(cell division)|interpro:IPR009563(Sjogrens syndrome scleroderma autoantigen 1)|rcsb pdb:6HCZ psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Uou80pZneoL39/0YYzb1TAbiB2I9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O15371 intact:EBI-6248094 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O15372 intact:EBI-6248094 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H4L5 intact:EBI-6248094 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99704 intact:EBI-6248094 intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P60228 intact:EBI-6248094 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TD16 intact:EBI-6248094 intact:EBI-2372628|uniprotkb:O75181|uniprotkb:Q5TBQ2|uniprotkb:Q5TBQ3|uniprotkb:Q96LH2|uniprotkb:Q9BT84|uniprotkb:Q9H561|ensembl:ENSP00000364662 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:bicd2_human(display_long)|uniprotkb:BICD2(gene name)|psi-mi:BICD2(display_short)|uniprotkb:KIAA0699(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001003800.1|refseq:NP_056065.1|dip:DIP-53426N|ensembl:ENSG00000185963(gene)|ensembl:ENST00000375512(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034452"(dynactin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|go:"GO:0072393"(microtubule anchoring at microtubule organizing center)|interpro:IPR018477|rcsb pdb:6OFP|rcsb pdb:6PSE|reactome:R-HSA-6811436 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:6MPNarWaiURuFhlX154W5E/1kpM9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UBQ5 intact:EBI-6248094 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O60610 intact:EBI-6248094 intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9Y262 intact:EBI-6248094 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6176962|imex:IM-17346-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:20CC1A4272652EC2|rigid:qoJNVND8ul+bz58uWSrQmGb6auc false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:O75037 intact:EBI-6164309 intact:EBI-6166435|ensembl:ENSP00000411831|uniprotkb:Q5T4J3|uniprotkb:B2RP62|uniprotkb:B7ZMI0|intact:EBI-11017531 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:ki21b_human(display_long)|uniprotkb:KIF21B(gene name)|psi-mi:KIF21B(display_short)|uniprotkb:KIAA0449(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177061|imex:IM-17346-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000116852(gene)|ensembl:ENST00000422435(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1990939"|interpro:IPR001680(WD40 repeat)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR019821|interpro:IPR027640|interpro:IPR036322|interpro:IPR036961|reactome:R-HSA-6811434|reactome:R-HSA-983189|interpro:IPR027417|refseq:NP_001239029.1|refseq:NP_001239031.1|refseq:NP_001239032.1|refseq:NP_060066.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:VQsDEkUYcMpRqaHJe3J4mcQhyiQ9606 intact-crc:7D67DEFB7ADB9701|rigid:IsuYDtwlAkKOgDOtDC6YR3nclA8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q8WV92 intact:EBI-6164309 intact:EBI-2691489|uniprotkb:Q69YV0|ensembl:ENSP00000289359 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:mitd1_human(display_long)|uniprotkb:MITD1(gene name)|psi-mi:MITD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177061|imex:IM-17346-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_620153.1|refseq:NP_001307346.1|refseq:NP_001307347.1|refseq:NP_001307348.1|ensembl:ENSG00000158411(gene)|ensembl:ENST00000289359(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007330(MIT)|interpro:IPR032341|interpro:IPR036181|interpro:IPR038113|rcsb pdb:2YMB|rcsb pdb:4A5X|rcsb pdb:4A5Z psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:VY5MeLAmoWXB0gKSJR3d9OhT1Vk9606 intact-crc:7D67DEFB7ADB9701|rigid:IsuYDtwlAkKOgDOtDC6YR3nclA8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:P67870 intact:EBI-6164309 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177061|imex:IM-17346-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 intact-crc:7D67DEFB7ADB9701|rigid:IsuYDtwlAkKOgDOtDC6YR3nclA8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:P82933 intact:EBI-6164309 intact:EBI-721385|intact:EBI-1049991|uniprotkb:Q6PG40|ensembl:ENSP00000258455 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:rt09_human(display_long)|uniprotkb:MRPS9(gene name)|psi-mi:MRPS9(display_short)|uniprotkb:RPMS9(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS9m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177061|imex:IM-17346-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_872578.1|ensembl:ENSG00000135972(gene)|ensembl:ENST00000258455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P82933|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSE psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:XNB4GL84eYgYFEB3WxOtoD3Ub989606 intact-crc:7D67DEFB7ADB9701|rigid:IsuYDtwlAkKOgDOtDC6YR3nclA8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04618 uniprotkb:Q9Y2Q9 intact:EBI-6164309 intact:EBI-5325249|ensembl:ENSP00000276585|uniprotkb:B2RDZ7|uniprotkb:Q96Q21 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:rt28_human(display_long)|uniprotkb:Mitochondrial small ribosomal subunit protein bS1m(gene name synonym)|uniprotkb:HSPC007(orf name)|uniprotkb:MRPS28(gene name)|psi-mi:MRPS28(display_short)|uniprotkb:MRPS35(gene name synonym)|uniprotkb:28S ribosomal protein S35, mitochondrial(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177061|imex:IM-17346-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENST00000276585(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR019375|mint:Q9Y2Q9|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|ensembl:ENSG00000147586(gene)|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_054737.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:E78l52n5CxYuz9U1JoMSG5jJjMA9606 intact-crc:7D67DEFB7ADB9701|rigid:IsuYDtwlAkKOgDOtDC6YR3nclA8 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12497-PRO_0000042399 uniprotkb:P62993 intact:EBI-6179753 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:p12497-pro_0000042399(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177090|imex:IM-17346-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1026248(chain-parent) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:588|chain-seq-end:1147|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Klpids91/HYZGIB9q9E28gVETBU11698 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:1D000DE356F8234A|rigid:0ebqCrs6hYEF5rqHrM/HQX0RyvE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12497-PRO_0000042399 uniprotkb:O14745 intact:EBI-6179753 intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389 psi-mi:p12497-pro_0000042399(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177090|imex:IM-17346-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1026248(chain-parent) refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) chain-seq-start:588|chain-seq-end:1147|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Klpids91/HYZGIB9q9E28gVETBU11698 rogid:03E30U6coFBcC3BeKOYnInfG/BI9606 intact-crc:1D000DE356F8234A|rigid:0ebqCrs6hYEF5rqHrM/HQX0RyvE false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O75607 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-721544|uniprotkb:Q9UNY6|intact:EBI-28974425|ensembl:ENSP00000359128 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:npm3_human(display_long)|uniprotkb:NPM3(gene name)|psi-mi:NPM3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_008924.1|ensembl:ENSP00000359128|ensembl:ENSG00000107833(gene)|ensembl:ENST00000370110(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0009303"(rRNA transcription)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042393"(histone binding)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR036824|mint:O75607 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:lryH+qFG3/zmXWyn25dmU44prpk9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q9UHB7 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q4G0J3 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371923|uniprotkb:B2ZHN6|uniprotkb:Q3B7A9|uniprotkb:Q9P1S7|uniprotkb:Q9Y3Z8|intact:EBI-2560173|ensembl:ENSP00000314311|ensembl:ENSP00000344950|ensembl:ENSP00000499190 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:larp7_human(display_long)|uniprotkb:LARP7(gene name)|psi-mi:LARP7(display_short)|uniprotkb:La ribonucleoprotein domain family member 7(gene name synonym)|uniprotkb:P-TEFb-interaction protein for 7SK stability(gene name synonym)|uniprotkb:HDCMA18P(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_056269.1|refseq:NP_057732.2|refseq:NP_001253968.1|dip:DIP-47624N|ensembl:ENSG00000174720(gene)|ensembl:ENST00000324052(transcript)|ensembl:ENST00000344442(transcript)|ensembl:ENST00000651579(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990438"(U6 2'-O-snRNA methylation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR034887|interpro:IPR034910|interpro:IPR034946|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|mint:Q4G0J3|rcsb pdb:4WKR|rcsb pdb:5KNW|rcsb pdb:6D12 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:ZIHCyGk7VI4irQOPvTXcNjk2ifw9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q7L2J0 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371983|uniprotkb:Q9NPD4|uniprotkb:B3KP86|uniprotkb:D6W5V7|ensembl:ENSP00000308546 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:mepce_human(display_long)|uniprotkb:MEPCE(gene name)|psi-mi:MEPCE(display_short)|uniprotkb:BCDIN3(gene name synonym)|uniprotkb:Bicoid-interacting protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:XP_011514712.1|refseq:NP_001181919.1|refseq:NP_001181920.1|refseq:NP_001181921.1|refseq:NP_062552.2|ensembl:ENSG00000146834(gene)|ensembl:ENST00000310512(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0017069"(snRNA binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0040031"(snRNA modification)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990276"(RNA 5'-methyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772|mint:Q7L2J0|rcsb pdb:5UNA|rcsb pdb:6DCB|rcsb pdb:6DCC psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:VGhJoO3FD7nsJPVSBsKuKsPJzEM9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q99733 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2255116|uniprotkb:B2R6J4|uniprotkb:F5HFY4|ensembl:ENSP00000369915|ensembl:ENSP00000483728 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:np1l4_human(display_long)|uniprotkb:NAP1L4(gene name)|psi-mi:NAP1L4(display_short)|uniprotkb:NAP2(gene name synonym)|uniprotkb:Nucleosome assembly protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_005960.1|ensembl:ENSG00000205531(gene)|ensembl:ENSG00000273562(gene)|ensembl:ENST00000380542(transcript)|ensembl:ENST00000619695(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q99733 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:tES8IJDlW4JONR/pdC8dq49I/7Y9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P51816 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1754468|uniprotkb:O43786|uniprotkb:O60215|uniprotkb:P78407|uniprotkb:Q13521|uniprotkb:Q14323|uniprotkb:Q9UNA5|uniprotkb:A2RTY4|uniprotkb:Q7Z2F7|uniprotkb:Q7Z400|uniprotkb:B7WNQ1|uniprotkb:B7ZLD6|uniprotkb:B7ZLD9|uniprotkb:B4DXD5|ensembl:ENSP00000359489 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff2_human(display_long)|uniprotkb:AFF2(gene name)|psi-mi:AFF2(display_short)|uniprotkb:FMR2(gene name synonym)|uniprotkb:OX19(gene name synonym)|uniprotkb:Fragile X mental retardation 2 protein(gene name synonym)|uniprotkb:Protein Ox19(gene name synonym)|uniprotkb:Fragile X E mental retardation syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001162593.1|refseq:NP_001162594.1|refseq:NP_001162595.1|refseq:NP_001162596.1|refseq:NP_002016.2|refseq:NP_001164099.1|ensembl:ENSG00000155966(gene)|ensembl:ENST00000370460(transcript)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0007420"(brain development)|go:"GO:0007611"(learning or memory)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043484"(regulation of RNA splicing)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.74 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:FsFS1MOddbWenE+b2UMca7Cc37g9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O43865 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O60563 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P51825 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P50750 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177111|imex:IM-17346-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA psi-mi:"MI:0007"(anti tag coimmunoprecipitation) crc64:4DDC56D979769115 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:0CB3B8CFEB48ECDD|rigid:QmdtGDfKOcGvKPiAuYkwIksr1/s false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:P25686 intact:EBI-779991 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:O75376 intact:EBI-779991 intact:EBI-347233|uniprotkb:E9PGV6|uniprotkb:Q86YY0|uniprotkb:Q9UPV5|uniprotkb:Q9UQ18|intact:EBI-28976482|ensembl:ENSP00000268712|uniprotkb:B3DLF8 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:ncor1_human(display_long)|uniprotkb:NCOR1(gene name)|psi-mi:NCOR1(display_short)|uniprotkb:KIAA1047(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL dip:DIP-29402N|ensembl:ENSP00000268712|ensembl:ENST00000395848|ensembl:ENSP00000379189|ensembl:ENST00000395851|ensembl:ENSP00000379192|ensembl:ENSG00000141027(gene)|ensembl:ENST00000268712(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016020"(membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045922"(negative regulation of fatty acid metabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:O75376|rcsb pdb:2EQR|rcsb pdb:3KMZ|rcsb pdb:3N00|rcsb pdb:4MDD|rcsb pdb:4WVD|rcsb pdb:6ONI|rcsb pdb:6WMQ|rcsb pdb:6XXS|rcsb pdb:6XYX|rcsb pdb:6XZZ|rcsb pdb:6Y17|rcsb pdb:6ZBU|reactome:R-HSA-1251985|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2173795|reactome:R-HSA-2644606|rcsb pdb:3H52|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-5617472|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564|reactome:R-HSA-9707616|refseq:XP_011522388.1|refseq:NP_001177369.1|refseq:NP_006302.2|refseq:NP_001177367.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:8W82xLRBbuJwVpXSvxoGQBu0v7Y9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9BZK7 intact:EBI-779991 intact:EBI-765729|uniprotkb:Q14DC3|uniprotkb:Q9H2I1|uniprotkb:Q9H9A1|uniprotkb:D3DNQ9|ensembl:ENSP00000263964|ensembl:ENSP00000387849|ensembl:ENSP00000405574|ensembl:ENSP00000413251|ensembl:ENSP00000501274 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:tbl1r_human(display_long)|uniprotkb:Transducin beta-like 1X-related protein 1(gene name synonym)|uniprotkb:Nuclear receptor corepressor/HDAC3 complex subunit TBLR1(gene name synonym)|uniprotkb:TBL1-related protein 1(gene name synonym)|uniprotkb:TBL1XR1(gene name)|psi-mi:TBL1XR1(display_short)|uniprotkb:IRA1(gene name synonym)|uniprotkb:TBLR1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_078941.2|refseq:XP_011511443.1|refseq:XP_011511444.1|refseq:XP_011511445.1|refseq:NP_001308123.1|refseq:NP_001308124.1|refseq:NP_001308122.1|refseq:XP_005247832.1|refseq:XP_006713809.1|refseq:XP_016862674.1|dip:DIP-34582N|ensembl:ENSG00000177565(gene)|ensembl:ENST00000422442(transcript)|ensembl:ENST00000352800(transcript)|ensembl:ENST00000430069(transcript)|ensembl:ENST00000457928(transcript)|ensembl:ENST00000673974(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016575"(histone deacetylation)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042393"(histone binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9BZK7|rcsb pdb:4LG9|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Sr6jJZT7jdfR/ps1xK1ySq9/TuI9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q16659 intact:EBI-779991 intact:EBI-1384105|uniprotkb:Q68DH4|uniprotkb:Q8IYN8|uniprotkb:B2R945|uniprotkb:B5BU65|ensembl:ENSP00000261845|ensembl:ENSP00000505601|ensembl:ENSP00000505862|ensembl:ENSP00000506036|ensembl:ENSP00000506184 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:mk06_human(display_long)|uniprotkb:ERK3(gene name synonym)|uniprotkb:PRKM6(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 3(gene name synonym)|uniprotkb:MAP kinase isoform p97(gene name synonym)|uniprotkb:MAPK6(gene name)|psi-mi:MAPK6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:XP_011520084.1|refseq:NP_002739.1|refseq:XP_005254594.1|refseq:XP_005254595.1|refseq:XP_005254596.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0032156"(septin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000069956(gene)|ensembl:ENST00000261845(transcript)|ensembl:ENST00000680066(transcript)|ensembl:ENST00000680652(transcript)|ensembl:ENST00000680777(transcript)|ensembl:ENST00000681888(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008350(ERK3/4 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6YKY|rcsb pdb:6YLC|rcsb pdb:6YLL|rcsb pdb:7AQB|reactome:R-HSA-5687128 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Gek79ujQv6Xznswv4ZIxXbgX4OE9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15369 intact:EBI-779991 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:O15379 intact:EBI-779991 intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:X5pnE98s15eXKev3nauN7ri5kqg9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13227 intact:EBI-779991 intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9C0C7 intact:EBI-779991 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15370 intact:EBI-779991 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9Y5V3 intact:EBI-779991 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9UBF6 intact:EBI-779991 intact:EBI-398632|uniprotkb:Q9BXN8|uniprotkb:Q9Y5M7|uniprotkb:A8MTB5|uniprotkb:A8K1H9|uniprotkb:D3DNF7|uniprotkb:D3DNF8|uniprotkb:C9JYL3|ensembl:ENSP00000273480 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:rbx2_human(display_long)|uniprotkb:RNF7(gene name)|psi-mi:RNF7(display_short)|uniprotkb:RBX2(gene name synonym)|uniprotkb:ROC2(gene name synonym)|uniprotkb:SAG(gene name synonym)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Regulator of cullins 2(gene name synonym)|uniprotkb:CKII beta-binding protein 1(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_055060.1|refseq:NP_899060.1|refseq:NP_001188299.1|ensembl:ENSG00000114125(gene)|ensembl:ENST00000273480(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|go:"GO:0051775"(response to redox state)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|rcsb pdb:2ECL|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:FNop0ozErv05khKc5si7nNH/Hww9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q8TEB1 intact:EBI-779991 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13617 intact:EBI-779991 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q93034 intact:EBI-779991 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177152|imex:IM-17346-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 intact-crc:F9C5E4E12889BEF5|rigid:HtL2SxxGpEt2i/Avw7GeEyzYmdw false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q5SW79 intact:EBI-6164519 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13409 intact:EBI-6164519 intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9UNS2 intact:EBI-6164519 intact:EBI-350590|uniprotkb:O43191|uniprotkb:Q7LDR6|uniprotkb:B2R683|ensembl:ENSP00000268717|uniprotkb:B4DY81 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn3_human(display_long)|uniprotkb:COPS3(gene name)|psi-mi:COPS3(display_short)|uniprotkb:CSN3(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001186054.1|refseq:NP_003644.2|ensembl:ENSG00000141030(gene)|ensembl:ENST00000268717(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009416"(response to light stimulus)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036390|interpro:IPR037753|mint:Q9UNS2|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|rcsb pdb:6R6H|refseq:NP_001303283.1|refseq:NP_001303284.1|refseq:NP_001303285.1|refseq:NP_001303286.1|refseq:NP_001303287.1|refseq:XP_005256894.1|dip:DIP-32478N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:z6E/tPEo/ksVxD5Yyfo89t+ww989606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9BW61 intact:EBI-6164519 intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q5TAQ9 intact:EBI-6164519 intact:EBI-740686|uniprotkb:Q12839|uniprotkb:Q4QQI6|uniprotkb:Q53F14|uniprotkb:Q66K50|uniprotkb:Q68CS7|uniprotkb:Q96E00|intact:EBI-2559125|uniprotkb:D3DVE6|ensembl:ENSP00000318227|ensembl:ENSP00000357052|ensembl:ENSP00000357053 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf8_human(display_long)|uniprotkb:DCAF8(gene name)|psi-mi:DCAF8(display_short)|uniprotkb:H326(gene name synonym)|uniprotkb:WDR42A(gene name synonym)|uniprotkb:WD repeat-containing protein 42A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_056541.2|ensembl:ENSG00000132716(gene)|ensembl:ENST00000326837(transcript)|ensembl:ENST00000368073(transcript)|ensembl:ENST00000368074(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q5TAQ9|rcsb pdb:3I8E|reactome:R-HSA-8951664|dip:DIP-48762N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:6Bbv6KwtHrJ0W4mcIronVPj4bTA9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O14893 intact:EBI-6164519 intact:EBI-443648|ensembl:ENSP00000250379|ensembl:ENSP00000308533|ensembl:ENSP00000379548|ensembl:ENSP00000416827|uniprotkb:Q2M3B3|uniprotkb:Q9H4F5|uniprotkb:Q9NS77|uniprotkb:Q9NS78|uniprotkb:Q9NS79|uniprotkb:B2R9W8 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:gemi2_human(display_long)|uniprotkb:GEMIN2(gene name)|psi-mi:GEMIN2(display_short)|uniprotkb:SIP1(gene name synonym)|uniprotkb:Component of gems 2(gene name synonym)|uniprotkb:Survival of motor neuron protein-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000092208(gene)|ensembl:ENST00000250379(transcript)|ensembl:ENST00000308317(transcript)|ensembl:ENST00000396249(transcript)|ensembl:ENST00000412033(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR017364(Survival of motor neuron protein interacting, gemin2)|interpro:IPR035426|mint:O14893|rcsb pdb:2LEH|rcsb pdb:5XJL|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|reactome:R-HSA-191859|refseq:NP_001009182.1|refseq:NP_001009183.1|refseq:NP_003607.1|dip:DIP-32605N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:cCbpiHhHdfq+SNoIud5xipHgYVA9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9BT78 intact:EBI-6164519 intact:EBI-742413|uniprotkb:Q561W7|uniprotkb:Q9NW31|uniprotkb:Q9Y677|uniprotkb:B3KN88|ensembl:ENSP00000264389|uniprotkb:B3KST5 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn4_human(display_long)|uniprotkb:COPS4(gene name)|psi-mi:COPS4(display_short)|uniprotkb:CSN4(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000138663(gene)|refseq:NP_057213.2|refseq:NP_001244935.1|go:"GO:0016607"(nuclear speck)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:Q9BT78|rcsb pdb:4D0P|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|ensembl:ENST00000264389(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|refseq:NP_001317656.1|dip:DIP-34516N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:onrZiPzG+bZvycmpDTZMtkPzCfQ9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8IWZ3 intact:EBI-6164519 intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16576 intact:EBI-6164519 intact:EBI-352227|ensembl:ENSP00000369427|intact:EBI-3505029|uniprotkb:Q5JP00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:rbbp7_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:RBAP46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_002884.1|ensembl:ENST00000380087(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q16576|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:7M3X|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8951664|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|ensembl:ENSG00000102054(gene)|refseq:NP_001185648.1|dip:DIP-436N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13619 intact:EBI-6164519 intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P61289 intact:EBI-6164519 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q7L5N1 intact:EBI-6164519 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P57678 intact:EBI-6164519 intact:EBI-356700|uniprotkb:Q9NZS7|uniprotkb:Q9UG32|uniprotkb:Q9Y4Q2|intact:EBI-1058464|ensembl:ENSP00000321706 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:gemi4_human(display_long)|uniprotkb:GEMIN4(gene name)|psi-mi:GEMIN4(display_short)|uniprotkb:Component of gems 4(gene name synonym)|uniprotkb:p97(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_056536.2|ensembl:ENSG00000179409(gene)|ensembl:ENST00000319004(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR033265|mint:P57678|reactome:R-HSA-191859 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:PeyFnc2VuUrZrCj8RtkVVS6KQF49606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8WXD5 intact:EBI-6164519 intact:EBI-752301|uniprotkb:Q53SI5|uniprotkb:Q8WVB4|uniprotkb:Q9H5G6|uniprotkb:B2RDP8|ensembl:ENSP00000281950 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:gemi6_human(display_long)|uniprotkb:SIP2(gene name synonym)|uniprotkb:GEMIN6(gene name)|psi-mi:GEMIN6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_079051.9|dip:DIP-41331N|ensembl:ENSG00000152147(gene)|ensembl:ENST00000281950(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR009422(Gemin6)|mint:Q8WXD5|rcsb pdb:1Y96|rcsb pdb:7BBL|reactome:R-HSA-191859 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:AaQyOsKgOMpkny7dYKmgwu0/c1g9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8IZ07 intact:EBI-6164519 intact:EBI-2876152|ensembl:ENSP00000261739|uniprotkb:O60736 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:an13a_human(display_long)|uniprotkb:ANKRD13A(gene name)|psi-mi:ANKRD13A(display_short)|uniprotkb:ANKRD13(gene name synonym)|uniprotkb:Protein KE03(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000076513(gene)|ensembl:ENST00000261739(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1905667"(negative regulation of protein localization to endosome)|interpro:IPR002110(Ankyrin)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR021832|interpro:IPR036770|refseq:NP_149112.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:RI4K5f4Ks8YSRYUO/FEQNCRkI389606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O75386 intact:EBI-6164519 intact:EBI-5357290|uniprotkb:B3KNB7|uniprotkb:D3DUQ4|uniprotkb:Q8N5B0|uniprotkb:B7Z6A2|uniprotkb:F8WBZ9|intact:EBI-28988689|ensembl:ENSP00000410051 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:tulp3_human(display_long)|uniprotkb:TULP3(gene name)|psi-mi:TULP3(display_short)|uniprotkb:TUBL3(gene name synonym)|uniprotkb:Tubby-like protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001153880.1|refseq:NP_003315.2|ensembl:ENST00000397132|ensembl:ENSP00000380321|ensembl:ENSP00000410051|ensembl:ENST00000540184|ensembl:ENSP00000444110|ensembl:ENSG00000078246(gene)|ensembl:ENST00000448120(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0019899"(enzyme binding)|go:"GO:0021914"(negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060348"(bone development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061548"(ganglion development)|go:"GO:0097546"(ciliary base)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:0120160"(intraciliary transport particle A binding)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000007(Tubby, C-terminal)|interpro:IPR005398(Tubby, N-terminal)|interpro:IPR018066|interpro:IPR025659|reactome:R-HSA-5610787 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:zfk5c5/u3lyjIQfvJWtmZeee0SI9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16637 intact:EBI-6164519 intact:EBI-395421|uniprotkb:Q13119|uniprotkb:Q549U5|uniprotkb:Q96J51|ensembl:ENSP00000305857|uniprotkb:A8K0V4|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENSP00000370119|ensembl:ENSP00000479920|ensembl:ENSP00000482966|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENSP00000487206|ensembl:ENSP00000487421 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:smn_human(display_long)|uniprotkb:SMN1(gene name)|psi-mi:SMN1(display_short)|uniprotkb:SMN(gene name synonym)|uniprotkb:SMNT(gene name synonym)|uniprotkb:SMN2(gene name)|psi-mi:SMN2(display_short)|uniprotkb:SMNC(gene name synonym)|uniprotkb:Component of gems 1(gene name synonym)|uniprotkb:Gemin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_000335.1|refseq:NP_059107.1|refseq:NP_075012.1|refseq:NP_075013.1|refseq:NP_075014.1|refseq:NP_075015.1|ensembl:ENSG00000172062(gene)|ensembl:ENSG00000205571(gene)|ensembl:ENSG00000273772(gene)|ensembl:ENSG00000275349(gene)|ensembl:ENSG00000277773(gene)|ensembl:ENST00000351205(transcript)|ensembl:ENST00000380707(transcript)|ensembl:ENST00000380741(transcript)|ensembl:ENST00000380743(transcript)|ensembl:ENST00000614610(transcript)|ensembl:ENST00000618251(transcript)|ensembl:ENST00000618661(transcript)|ensembl:ENST00000622739(transcript)|ensembl:ENST00000627341(transcript)|ensembl:ENST00000629122(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0007399"(nervous system development)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR002999(Tudor)|interpro:IPR010304(Survival motor neuron)|mint:Q16637|rcsb pdb:1G5V|rcsb pdb:1MHN|rcsb pdb:2LEH|rcsb pdb:4A4E|rcsb pdb:4A4G|rcsb pdb:4GLI|rcsb pdb:4QQ6|rcsb pdb:5XJL|go:"GO:0034719"(SMN-Sm protein complex)|rcsb pdb:5XJQ|rcsb pdb:5XJR|rcsb pdb:5XJS|rcsb pdb:5XJT|rcsb pdb:5XJU|reactome:R-HSA-191859|go:"GO:0032797"(SMN complex)|refseq:NP_001284644.1|ensembl:ENSP00000305857|ensembl:ENSP00000370083|ensembl:ENSP00000370117|ensembl:ENST00000380742|ensembl:ENSP00000370118|ensembl:ENSP00000370119|ensembl:ENST00000503079|ensembl:ENSP00000428128|ensembl:ENST00000506163|ensembl:ENSP00000424926|ensembl:ENST00000611442|ensembl:ENSP00000483768|ensembl:ENST00000614240|ensembl:ENSP00000479279|ensembl:ENSP00000479920|ensembl:ENST00000614773|ensembl:ENSP00000481427|ensembl:ENSP00000483515|ensembl:ENSP00000483819|ensembl:ENST00000622158|ensembl:ENSP00000480906|ensembl:ENSP00000482966|ensembl:ENST00000624634|ensembl:ENSP00000485595|ensembl:ENST00000626847|ensembl:ENSP00000486152|ensembl:ENSP00000487421|ensembl:ENST00000628353|ensembl:ENSP00000487029|ensembl:ENST00000628642|ensembl:ENSP00000487015|ensembl:ENSP00000487206|refseq:XP_016865275.1|dip:DIP-31309N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:QGivm7E8suciCWXO4l0zCUzCl2g9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13098 intact:EBI-6164519 intact:EBI-725197|uniprotkb:Q8NA10|uniprotkb:Q9BWL1|ensembl:ENSP00000302873 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn1_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)|uniprotkb:Protein MFH(gene name synonym)|uniprotkb:GPS1(gene name)|psi-mi:GPS1(display_short)|uniprotkb:COPS1(gene name synonym)|uniprotkb:CSN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_004118.3|refseq:NP_997657.1|ensembl:ENSG00000169727(gene)|ensembl:ENST00000306823(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR019585|interpro:IPR033008|interpro:IPR036390|mint:Q13098|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0008180"(COP9 signalosome)|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|refseq:NP_001308021.1|refseq:XP_016880023.1|dip:DIP-42077N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:OMWZ67qcgKTM0R/hy8L2oCa3cpo9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16531 intact:EBI-6164519 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O75179 intact:EBI-6164519 intact:EBI-355530|uniprotkb:Q6PJ85|uniprotkb:Q6PK85|uniprotkb:Q6PKA2|uniprotkb:Q86XI3|uniprotkb:Q8NDR5|uniprotkb:Q96I86|uniprotkb:Q9H6J9|uniprotkb:Q9H288|ensembl:ENSP00000351416|uniprotkb:G5E964|uniprotkb:E7EUV3 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:anr17_human(display_long)|uniprotkb:ANKRD17(gene name)|psi-mi:ANKRD17(display_short)|uniprotkb:GTAR(gene name synonym)|uniprotkb:KIAA0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-16(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_115593.3|refseq:NP_942592.1|refseq:NP_056389.1|ensembl:ENSG00000132466(gene)|ensembl:ENST00000358602(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:O75179|go:"GO:0031965"(nuclear membrane)|refseq:NP_001273700.1|ensembl:ENST00000330838|ensembl:ENSP00000332265|ensembl:ENSP00000351416|ensembl:ENST00000509867|ensembl:ENSP00000427151|dip:DIP-47290N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:l/gkMCasWF6pn6feuIzeQKWwwKM9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P61201 intact:EBI-6164519 intact:EBI-1050386|uniprotkb:O88950|uniprotkb:Q15647|uniprotkb:Q6FGP4|uniprotkb:Q9BY54|uniprotkb:Q9R249|uniprotkb:Q9UNI2|uniprotkb:Q9UNQ5|ensembl:ENSP00000373553 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn2_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 2(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 15(gene name synonym)|uniprotkb:Alien homolog(gene name synonym)|uniprotkb:COPS2(gene name)|psi-mi:COPS2(display_short)|uniprotkb:CSN2(gene name synonym)|uniprotkb:TRIP15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001137359.1|refseq:NP_004227.1|ensembl:ENSG00000166200(gene)|ensembl:ENST00000388901(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR036390|interpro:IPR037750|mint:P61201|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6A73|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|dip:DIP-42076N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:MrlEHktIBvvcQux7Z7kqYJYgbbs9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:P13051 intact:EBI-6164519 intact:EBI-1025947|uniprotkb:O00637|uniprotkb:O00719|uniprotkb:Q93028|uniprotkb:A8K5M6|uniprotkb:B2R8Y1|ensembl:ENSP00000242576 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ung_human(display_long)|uniprotkb:UNG(gene name)|psi-mi:UNG(display_short)|uniprotkb:DGU(gene name synonym)|uniprotkb:UNG15(gene name synonym)|uniprotkb:UNG1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003353.1|refseq:NP_550433.1|ensembl:ENSG00000076248(gene)|ensembl:ENST00000242576(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0004844"(uracil DNA N-glycosylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045008"(depyrimidination)|go:"GO:0045190"(isotype switching)|go:"GO:0097510"(base-excision repair, AP site formation via deaminated base removal)|interpro:IPR002043(Uracil-DNA glycosylase)|interpro:IPR005122(Uracil-DNA glycosylase-like)|interpro:IPR018085|interpro:IPR036895|rcsb pdb:1AKZ|rcsb pdb:1DPU|rcsb pdb:1EMH|rcsb pdb:1EMJ|rcsb pdb:1Q3F|rcsb pdb:1SSP|rcsb pdb:1UGH|rcsb pdb:1YUO|rcsb pdb:2HXM|rcsb pdb:2OXM|rcsb pdb:2OYT|rcsb pdb:2SSP|rcsb pdb:3FCF|rcsb pdb:3FCI|rcsb pdb:3FCK|rcsb pdb:3FCL|rcsb pdb:3TKB|rcsb pdb:4SKN|rcsb pdb:5AYR|rcsb pdb:5JK7|rcsb pdb:6VBA|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110357|dip:DIP-24194N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:pjzUi17Vpmhp1JddThFwPvNhZCE9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y6G9 intact:EBI-6164519 intact:EBI-2556107|uniprotkb:A2RRG7|uniprotkb:Q53HK7|uniprotkb:Q53HC8|ensembl:ENSP00000273130 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1l1_human(display_long)|uniprotkb:DNCLI1(gene name synonym)|uniprotkb:Dynein light intermediate chain 1, cytosolic(gene name synonym)|uniprotkb:Dynein light chain A(gene name synonym)|uniprotkb:DYNC1LI1(gene name)|psi-mi:DYNC1LI1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_057225.2|ensembl:ENSG00000144635(gene)|ensembl:ENST00000273130(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0051301"(cell division)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|mint:Q9Y6G9|rcsb pdb:6B9H|rcsb pdb:6PSD|rcsb pdb:6PSE|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0007018"(microtubule-based movement) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:LxQSfBpzuf6Acus2jBy0s53FdhU9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q92905 intact:EBI-6164519 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q14204 intact:EBI-6164519 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9H840 intact:EBI-6164519 intact:EBI-715455|uniprotkb:Q6IA34|ensembl:ENSP00000375813|ensembl:ENSP00000465704|ensembl:ENSP00000466342|ensembl:ENSP00000270257 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:gemi7_human(display_long)|uniprotkb:SIP3(gene name synonym)|uniprotkb:GEMIN7(gene name)|psi-mi:GEMIN7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:XP_005259319.1|refseq:XP_005259320.1|refseq:NP_001007270.1|refseq:NP_001007271.1|refseq:NP_078983.1|ensembl:ENSG00000142252(gene)|ensembl:ENST00000270257(transcript)|ensembl:ENST00000391951(transcript)|ensembl:ENST00000591607(transcript)|ensembl:ENST00000591747(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0120114"(Sm-like protein family complex)|interpro:IPR020338|interpro:IPR024642|mint:Q9H840|rcsb pdb:1Y96|rcsb pdb:7BBL|reactome:R-HSA-191859|refseq:NP_001305983.1|refseq:NP_001305984.1|refseq:XP_016882801.1|dip:DIP-41750N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:jnNKbzuQxiIWKDmv7+je9B5U81Q9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q99627 intact:EBI-6164519 intact:EBI-2510102|ensembl:ENSP00000346340|uniprotkb:A8K1H6|uniprotkb:Q53QS9 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn8_human(display_long)|uniprotkb:COPS8(gene name)|psi-mi:COPS8(display_short)|uniprotkb:CSN8(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 8(gene name synonym)|uniprotkb:COP9 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000198612(gene)|ensembl:ENST00000354371(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR033205|interpro:IPR033464|mint:Q99627|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006701.1|refseq:NP_937832.1|dip:DIP-42075N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:3L+8IdjEw+ZC5MERztdPAY2ww389606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9UHI6 intact:EBI-6164519 intact:EBI-347658|uniprotkb:Q96F72|uniprotkb:Q9NVM3|uniprotkb:Q9UF59|uniprotkb:Q9UIY0|uniprotkb:Q9Y659|uniprotkb:B4DWV7|ensembl:ENSP00000358716|ensembl:ENSP00000505857 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ddx20_human(display_long)|uniprotkb:DDX20(gene name)|psi-mi:DDX20(display_short)|uniprotkb:DP103(gene name synonym)|uniprotkb:GEMIN3(gene name synonym)|uniprotkb:DEAD box protein 20(gene name synonym)|uniprotkb:DEAD box protein DP 103(gene name synonym)|uniprotkb:Component of gems 3(gene name synonym)|uniprotkb:Gemin-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_009135.4|ensembl:ENSP00000358716|ensembl:ENST00000533164|ensembl:ENSP00000434085|ensembl:ENSP00000505857|dip:DIP-32606N|ensembl:ENSG00000064703(gene)|ensembl:ENST00000369702(transcript)|ensembl:ENST00000679724(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006396"(RNA processing)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048477"(oogenesis)|go:"GO:0050810"(regulation of steroid biosynthetic process)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0097504"(Gemini of coiled bodies)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9UHI6|rcsb pdb:2OXC|rcsb pdb:3B7G|reactome:R-HSA-191859|go:"GO:0043065"(positive regulation of apoptotic process) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:Q9IGbhb825yL12imyTlBAHZ4YyU9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y4B6 intact:EBI-6164519 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177205|imex:IM-17346-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:B044481B80DF0B19|rigid:kccwEWL0p6kUZEFk6K/QPHAvRXk false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q86T03 intact:EBI-6248147 intact:EBI-6164623|uniprotkb:B2RA35|uniprotkb:Q86U09|uniprotkb:Q8WUC0|uniprotkb:Q9BU67|uniprotkb:Q9NSU8|ensembl:ENSP00000250489 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:pp4p1_human(display_long)|uniprotkb:PIP4P1(gene name)|psi-mi:PIP4P1(display_short)|uniprotkb:C14orf9(gene name synonym)|uniprotkb:PtdIns-4,5-P2 4-Ptase I(gene name synonym)|uniprotkb:TMEM55B(gene name synonym)|uniprotkb:Transmembrane protein 55B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSP00000250489|ensembl:ENST00000398020|ensembl:ENSP00000381102|refseq:NP_001094284.1|refseq:NP_653169.2|ensembl:ENSG00000165782(gene)|ensembl:ENST00000250489(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0070070"(proton-transporting V-type ATPase complex assembly)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR019178|reactome:R-HSA-6811555|reactome:R-HSA-8847453 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nbc8AvBd7g6bpNjfhhK7aPZ0BYk9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96F15 intact:EBI-6248147 intact:EBI-6166686|ensembl:ENSP00000351473|ensembl:ENSP00000487840|uniprotkb:D3DWZ5|uniprotkb:Q6IA75|uniprotkb:Q96NE4|uniprotkb:Q9NUK9 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:gima5_human(display_long)|uniprotkb:GIMAP5(gene name)|psi-mi:GIMAP5(display_short)|uniprotkb:IAN4L1(gene name synonym)|uniprotkb:IAN5(gene name synonym)|uniprotkb:IMAP3(gene name synonym)|uniprotkb:Immunity-associated nucleotide 4-like 1 protein(gene name synonym)|uniprotkb:Immunity-associated nucleotide 5 protein(gene name synonym)|uniprotkb:Immunity-associated protein 3(gene name synonym)|uniprotkb:Immune-associated nucleotide-binding protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000196329(gene)|ensembl:ENST00000358647(transcript)|ensembl:ENST00000498181(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032585"(multivesicular body membrane)|interpro:IPR006703(AIG1)|interpro:IPR027417|refseq:NP_060854.2|dip:DIP-59484N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:DchT8vcce8oKbvAQeC2nbxH17Xg9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P42695 intact:EBI-6248147 intact:EBI-722805|uniprotkb:A6NFS2|uniprotkb:Q4KMQ9|ensembl:ENSP00000433681 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cndd3_human(display_long)|uniprotkb:Non-SMC condensin II complex subunit D3(gene name synonym)|uniprotkb:NCAPD3(gene name)|psi-mi:NCAPD3(display_short)|uniprotkb:CAPD3(gene name synonym)|uniprotkb:KIAA0056(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_056076.1|dip:DIP-43903N|ensembl:ENSG00000151503(gene)|ensembl:ENST00000534548(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012371(Chromosome condensation protein, HCP-6-related)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|mint:P42695|reactome:R-HSA-2299718 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:z5WYLlrGt33uAM9NRN9SQeHFDaA9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UKB1 intact:EBI-6248147 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P78527 intact:EBI-6248147 intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P42704 intact:EBI-6248147 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P24539 intact:EBI-6248147 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q6P2E9 intact:EBI-6248147 intact:EBI-1006038|uniprotkb:Q13025|uniprotkb:Q13826|uniprotkb:Q6ZR12|uniprotkb:Q7Z6H7|uniprotkb:A6NGM1|uniprotkb:A8K4T4|ensembl:ENSP00000351811 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:edc4_human(display_long)|uniprotkb:Human enhancer of decapping large subunit(gene name synonym)|uniprotkb:Autoantigen Ge-1(gene name synonym)|uniprotkb:Autoantigen RCD-8(gene name synonym)|uniprotkb:EDC4(gene name)|psi-mi:EDC4(display_short)|uniprotkb:HEDLS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000038358(gene)|interpro:IPR036322|mint:Q6P2E9|reactome:R-HSA-430039|ensembl:ENST00000358933(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR032401|refseq:NP_055144.3|dip:DIP-31192N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:V5obZo71xmJbNRv5fc+o7wNdb+Y9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P30049 intact:EBI-6248147 intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P13598 intact:EBI-6248147 intact:EBI-2806056|ensembl:ENSP00000464665|uniprotkb:Q14600|ensembl:ENSP00000388666|ensembl:ENSP00000392634|ensembl:ENSP00000415283|ensembl:ENSP00000462579 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:icam2_human(display_long)|uniprotkb:ICAM2(gene name)|psi-mi:ICAM2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000412356(transcript)|ensembl:ENST00000418105(transcript)|ensembl:ENST00000449662(transcript)|ensembl:ENST00000579687(transcript)|ensembl:ENST00000579788(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015653(Intercellular adhesion molecule 2)|interpro:IPR036179|rcsb pdb:1ZXQ|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-5621575|refseq:NP_000864.2|refseq:NP_001093256.1|refseq:NP_001093257.1|refseq:NP_001093258.1|refseq:NP_001093259.1|ensembl:ENSG00000108622(gene) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:46FxUe9wv2WIelobimN/4k+qSS89606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96P70 intact:EBI-6248147 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P06576 intact:EBI-6248147 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q63HN8 intact:EBI-6248147 intact:EBI-1058832|intact:EBI-1059339|uniprotkb:Q8TEU0|uniprotkb:Q9H6C9|uniprotkb:C9JCP4|uniprotkb:D6RI12|uniprotkb:F8WKS1|uniprotkb:Q658P6|uniprotkb:Q6MZR1|uniprotkb:Q9H6H9|uniprotkb:Q9H6P3|uniprotkb:Q9H8A9|uniprotkb:Q9HCF4|uniprotkb:Q9HCL8|uniprotkb:Q69YK7|uniprotkb:Q8IWF4|uniprotkb:Q8IZX1|uniprotkb:Q8IZX2|uniprotkb:Q8N406 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rn213_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase RNF213(gene name synonym)|uniprotkb:RNF213(gene name)|psi-mi:RNF213(display_short)|uniprotkb:ALK lymphoma oligomerization partner on chromosome 17(gene name synonym)|uniprotkb:ALO17(gene name synonym)|uniprotkb:C17orf27(gene name synonym)|uniprotkb:KIAA1554(gene name synonym)|uniprotkb:KIAA1618(gene name synonym)|uniprotkb:MYSTR(gene name synonym)|uniprotkb:Mysterin(gene name synonym)|uniprotkb:RING finger protein 213(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018957|go:"GO:0001525"(angiogenesis)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|reactome:R-HSA-9635465|reactome:R-HSA-983168|refseq:NP_001243000.2|interpro:IPR027417|refseq:NP_066005.2|ensembl:ENST00000319921|ensembl:ENSP00000324392|ensembl:ENSG00000173821|interpro:IPR031248|mint:Q63HN8 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:M5TG5F1xZSNNeYTLh0H6WMqUHGs9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q13616 intact:EBI-6248147 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q15185 intact:EBI-6248147 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UHQ9 intact:EBI-6248147 intact:EBI-953870|ensembl:ENSP00000356218|uniprotkb:A0PK21|uniprotkb:O95329|uniprotkb:Q53F73|uniprotkb:Q8NCL5|uniprotkb:Q9UHJ1|uniprotkb:B2R8E0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:nb5r1_human(display_long)|uniprotkb:"NAD(P)H:quinone oxidoreductase type 3 polypeptide A2"(gene name synonym)|uniprotkb:Humb5R2(gene name synonym)|uniprotkb:CYB5R1(gene name)|psi-mi:CYB5R1(display_short)|uniprotkb:NQO3A2(gene name synonym)|uniprotkb:UNQ3049/PRO9865(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000159348(gene)|ensembl:ENST00000367249(transcript)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071949"(FAD binding)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-HSA-114608|reactome:R-HSA-1237044|go:"GO:0016020"(membrane)|refseq:NP_057327.2 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:TOvJYSyfYu73Ac/SYjup+ABu74g9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P26038 intact:EBI-6248147 intact:EBI-528768|ensembl:ENSP00000353408 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9GZT3 intact:EBI-6248147 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P55084 intact:EBI-6248147 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O14828 intact:EBI-6248147 intact:EBI-4401333|ensembl:ENSP00000307275|ensembl:ENSP00000461521|uniprotkb:A9Z1W6|uniprotkb:B1AVS6|uniprotkb:O15128|uniprotkb:Q96FR8|uniprotkb:Q9BPY0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:scam3_human(display_long)|uniprotkb:SCAMP3(gene name)|psi-mi:SCAMP3(display_short)|uniprotkb:C1orf3(gene name synonym)|uniprotkb:PROPIN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000116521(gene)|ensembl:ENSG00000263290(gene)|ensembl:ENST00000302631(transcript)|ensembl:ENST00000570831(transcript)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O14828|ensembl:ENSP00000307275|ensembl:ENST00000355379|ensembl:ENSP00000347540|ensembl:ENSP00000461521|ensembl:ENST00000573013|ensembl:ENSP00000458542|refseq:NP_005689.2|refseq:NP_443069.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:q1GaoVa7cLS2hGHVUM5Nv2oX4x09606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P40939 intact:EBI-6248147 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O75947 intact:EBI-6248147 intact:EBI-724024|ensembl:ENSP00000301587|uniprotkb:Q9H3J4|uniprotkb:B2R5L6 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atp5h_human(display_long)|uniprotkb:ATP5PD(gene name)|psi-mi:ATP5PD(display_short)|uniprotkb:ATP synthase peripheral stalk subunit d(gene name synonym)|uniprotkb:ATP5H(gene name synonym)|uniprotkb:My032(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001003785.1|refseq:NP_006347.1|ensembl:ENSG00000167863(gene)|ensembl:ENST00000301587(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|interpro:IPR008689(ATPase, F0 complex, subunit D, mitochondrial)|interpro:IPR036228|mint:O75947|reactome:R-HSA-163210|reactome:R-HSA-8949613 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:GFk/w7iWIjum9BpZs8ZlPrM5kBs9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P18859 intact:EBI-6248147 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NQC3 intact:EBI-6248147 intact:EBI-715945|intact:EBI-1753019|uniprotkb:O94962|uniprotkb:Q9BXG5|uniprotkb:Q9H212|uniprotkb:Q9H3I3|uniprotkb:Q9UQ42|uniprotkb:Q9Y293|uniprotkb:Q9Y2Y7|uniprotkb:Q9Y5U6|intact:EBI-1958210|intact:EBI-1056082|uniprotkb:Q7L7Q8|uniprotkb:Q96B16|intact:EBI-28967519|ensembl:ENSP00000337838|uniprotkb:Q7L7Q5|uniprotkb:Q7L7Q6|uniprotkb:Q8IUA4 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn4_human(display_long)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000317610|ensembl:ENSP00000322147|ensembl:ENSP00000337838|ensembl:ENST00000357376|ensembl:ENSP00000349944|ensembl:ENST00000357732|ensembl:ENSP00000350365|ensembl:ENST00000394609|ensembl:ENSP00000378107|ensembl:ENST00000394611|ensembl:ENSP00000378109|ensembl:ENST00000404909|ensembl:ENSP00000385650|ensembl:ENST00000405240|ensembl:ENSP00000384471|refseq:NP_008939.1|refseq:NP_065393.1|refseq:NP_722550.1|refseq:NP_997403.1|refseq:NP_997404.1|ensembl:ENSG00000115310(gene)|ensembl:ENST00000337526(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q9NQC3|rcsb pdb:2G31|rcsb pdb:2JV5|reactome:R-HSA-193634|refseq:XP_005264491.1|refseq:NP_001308788.1|refseq:NP_001308789.1|refseq:NP_001308790.1|refseq:NP_001308791.1|refseq:NP_001308792.1|refseq:NP_001308833.1|refseq:XP_016860007.1|refseq:XP_016860008.1|dip:DIP-42003N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:uhivTNOPdC7+q81CliY0Ozu0EwA9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q8TC07 intact:EBI-6248147 intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q5T9A4 intact:EBI-6248147 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P63208 intact:EBI-6248147 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95197 intact:EBI-6248147 intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96G23 intact:EBI-6248147 intact:EBI-1057080|uniprotkb:Q9HD96|uniprotkb:Q9NW79|uniprotkb:D3DV06|uniprotkb:Q5SZE5|ensembl:ENSP00000271688|ensembl:ENSP00000357950 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cers2_human(display_long)|uniprotkb:CERS2(gene name)|psi-mi:CERS2(display_short)|uniprotkb:TMSG1(gene name synonym)|uniprotkb:Tumor metastasis-suppressor gene 1 protein(gene name synonym)|uniprotkb:SP260(gene name synonym)|uniprotkb:LASS2(gene name synonym)|uniprotkb:LAG1 longevity assurance homolog 2(gene name synonym)|uniprotkb:Sphingosine N-acyltransferase CERS2(gene name synonym)|uniprotkb:Very-long-chain ceramide synthase CERS2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:XP_011507754.1|refseq:NP_071358.1|refseq:NP_859530.1|ensembl:ENSG00000143418(gene)|ensembl:ENST00000271688(transcript)|ensembl:ENST00000368954(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016410"(N-acyltransferase activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050291"(sphingosine N-acyltransferase activity)|go:"GO:1900148"(negative regulation of Schwann cell migration)|interpro:IPR001356(Homeobox)|interpro:IPR006634(TRAM, LAG1 and CLN8 homology)|interpro:IPR009057(Homeodomain-like)|interpro:IPR016439(Longevity assurance, LAG1/LAC1)|mint:Q96G23|reactome:R-HSA-1660661|go:"GO:1905045"(negative regulation of Schwann cell proliferation involved in axon regeneration) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:Eqxvp+41fFXPr+hpqRQsLB6Lq4M9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P48047 intact:EBI-6248147 intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q86XR8 intact:EBI-6248147 intact:EBI-308614|uniprotkb:Q14704|uniprotkb:Q8IXP0|uniprotkb:Q9BVF9|uniprotkb:Q5JB46|uniprotkb:A0PJH1|uniprotkb:A8K5D0|uniprotkb:B4DDP5|ensembl:ENSP00000317902|uniprotkb:F5H5F7 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cep57_human(display_long)|uniprotkb:CEP57(gene name)|psi-mi:CEP57(display_short)|uniprotkb:Testis-specific protein 57(gene name synonym)|uniprotkb:Translokin(gene name synonym)|uniprotkb:FGF2-interacting protein(gene name synonym)|uniprotkb:KIAA0092(gene name synonym)|uniprotkb:TSP57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 go:"GO:0007286"(spermatid development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR010597(Protein of unknown function DUF1167)|interpro:IPR024957|interpro:IPR025913|rcsb pdb:4L0R|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000166037(gene)|ensembl:ENST00000325542(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|refseq:NP_055494.2|refseq:NP_001230705.1|refseq:NP_001230706.1|refseq:XP_016874081.1 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:zlDjuw8lnfiXHeOeieJPekAcxD09606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UBB4 intact:EBI-6248147 intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q99653 intact:EBI-6248147 intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916 psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NVI7 intact:EBI-6248147 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177303|imex:IM-17346-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N psi-mi:"MI:0007"(anti tag coimmunoprecipitation) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 intact-crc:D805E5A0FE8F1639|rigid:OYnuGH/W3vy6j7Vx8a4lPNRyL5M false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P20701 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-961214|ensembl:ENSP00000349252|uniprotkb:O43746|uniprotkb:Q45H73|uniprotkb:Q9UBC8|intact:EBI-3962403|uniprotkb:Q96HB1 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ital_human(display_long)|uniprotkb:ITGAL(gene name)|psi-mi:ITGAL(display_short)|uniprotkb:CD11A(gene name synonym)|uniprotkb:Leukocyte adhesion glycoprotein LFA-1 alpha chain(gene name synonym)|uniprotkb:Leukocyte function-associated molecule 1 alpha chain(gene name synonym)|uniprotkb:CD11 antigen-like family member A(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_002200.2|ensembl:ENSG00000005844(gene)|ensembl:ENST00000356798(transcript)|go:"GO:0002291"(T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035683"(memory T cell extravasation)|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|interpro:IPR036465|rcsb pdb:1CQP|rcsb pdb:1DGQ|rcsb pdb:1IJ4|rcsb pdb:1LFA|rcsb pdb:1MJN|rcsb pdb:1MQ8|rcsb pdb:1MQ9|rcsb pdb:1MQA|rcsb pdb:1RD4|rcsb pdb:1T0P|rcsb pdb:1XDD|rcsb pdb:1XDG|rcsb pdb:1XUO|rcsb pdb:1ZON|rcsb pdb:1ZOO|rcsb pdb:1ZOP|rcsb pdb:2ICA|rcsb pdb:2K8O|rcsb pdb:2M3E|rcsb pdb:2O7N|rcsb pdb:3BN3|rcsb pdb:3BQM|rcsb pdb:3BQN|rcsb pdb:3E2M|rcsb pdb:3EOA|rcsb pdb:3EOB|rcsb pdb:3F74|rcsb pdb:3HI6|rcsb pdb:3F78|rcsb pdb:3M6F|rcsb pdb:3TCX|rcsb pdb:4IXD|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6798695|reactome:R-HSA-8949275|refseq:NP_001107852.1|dip:DIP-623N psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:JeiBJZbkw8mtrE7WrFlkepPiAOY9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96IV0 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165879|ensembl:ENSP00000280700|uniprotkb:B4DJE9|uniprotkb:Q59FB1|uniprotkb:Q6PJD8|uniprotkb:Q9BVR8|uniprotkb:Q9NR70 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ngly1_human(display_long)|uniprotkb:NGLY1(gene name)|psi-mi:NGLY1(display_short)|uniprotkb:N-glycanase 1(gene name synonym)|uniprotkb:PNG1(gene name synonym)|uniprotkb:"Peptide:N-glycanase"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000151092(gene)|ensembl:ENST00000280700(transcript)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR006588(Protein of unknown function PAW)|interpro:IPR008979(Galactose-binding like)|interpro:IPR018997|interpro:IPR036339|interpro:IPR038680|interpro:IPR038765|mint:Q96IV0|rcsb pdb:2CCQ|rcsb pdb:2CM0|reactome:R-HSA-532668|refseq:NP_001138767.1|refseq:NP_060767.2|refseq:NP_001138765.1|refseq:NP_001138766.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:CujOKLkvqxGmWpFvJM3B894PHqc9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P43630 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165894|ensembl:ENSP00000479425|ensembl:ENSP00000479772|ensembl:ENSP00000325525|ensembl:ENSP00000477516|ensembl:ENSP00000477519|ensembl:ENSP00000478251|ensembl:ENSP00000479299|ensembl:ENSP00000479903|ensembl:ENSP00000481209|ensembl:ENSP00000481579|ensembl:ENSP00000481662|ensembl:ENSP00000482110|ensembl:ENSP00000482301|ensembl:ENSP00000482565|ensembl:ENSP00000491183|ensembl:ENSP00000491303|ensembl:ENSP00000491436|ensembl:ENSP00000492261|uniprotkb:Q13238|uniprotkb:Q14947|uniprotkb:Q14948|uniprotkb:Q92684|uniprotkb:Q95367|uniprotkb:Q95368|uniprotkb:Q95366 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ki3l2_human(display_long)|uniprotkb:KIR3DL2(gene name)|psi-mi:KIR3DL2(display_short)|uniprotkb:CD158 antigen-like family member K(gene name synonym)|uniprotkb:CD158K(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:NKAT4(gene name synonym)|uniprotkb:Natural killer-associated transcript 4(gene name synonym)|uniprotkb:p70 natural killer cell receptor clone CL-5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000240403(gene)|ensembl:ENSG00000274722(gene)|ensembl:ENSG00000275083(gene)|ensembl:ENSG00000275416(gene)|ensembl:ENSG00000275566(gene)|ensembl:ENSG00000275626(gene)|ensembl:ENSG00000276004(gene)|ensembl:ENSG00000276357(gene)|ensembl:ENSG00000276739(gene)|ensembl:ENSG00000277181(gene)|ensembl:ENSG00000278361(gene)|ensembl:ENSG00000278442(gene)|ensembl:ENSG00000278474(gene)|ensembl:ENSG00000278809(gene)|ensembl:ENSG00000283951(gene)|ensembl:ENSG00000283975(gene)|ensembl:ENSG00000284063(gene)|ensembl:ENSG00000284381(gene)|ensembl:ENST00000326321(transcript)|ensembl:ENST00000611608(transcript)|ensembl:ENST00000611628(transcript)|ensembl:ENST00000613610(transcript)|ensembl:ENST00000613612(transcript)|ensembl:ENST00000614753(transcript)|ensembl:ENST00000617354(transcript)|ensembl:ENST00000617666(transcript)|ensembl:ENST00000617957(transcript)|ensembl:ENST00000619683(transcript)|ensembl:ENST00000620817(transcript)|ensembl:ENST00000621155(transcript)|ensembl:ENST00000622024(transcript)|ensembl:ENST00000622453(transcript)|ensembl:ENST00000638330(transcript)|ensembl:ENST00000638891(transcript)|ensembl:ENST00000638970(transcript)|ensembl:ENST00000640782(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0023029"(MHC class Ib protein binding)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|refseq:NP_001229796.1|refseq:NP_006728.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:z6uiSVZQ/gMCPqiX5E6syx6t3jY9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9NWW5 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165897|ensembl:ENSP00000249806|uniprotkb:B4DDH6|uniprotkb:A8K560|uniprotkb:Q6IAB1|uniprotkb:Q96SR0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:cln6_human(display_long)|uniprotkb:CLN6(gene name)|psi-mi:CLN6(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000128973(gene)|ensembl:ENST00000249806(transcript)|go:"GO:0001573"(ganglioside metabolic process)|go:"GO:0005730"(nucleolus)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007601"(visual perception)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044265"(cellular macromolecule catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0120146"(sulfatide binding)|interpro:IPR029255|refseq:NP_060352.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:oX9lqo/LjQbBWTpBj1voRRmnOO89606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14696 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165891|ensembl:ENSP00000261758|ensembl:ENSP00000453430|ensembl:ENSP00000482455|uniprotkb:D3DW96|uniprotkb:Q969U1|uniprotkb:B4DW84 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:mesd_human(display_long)|uniprotkb:MESD(gene name)|psi-mi:MESD(display_short)|uniprotkb:KIAA0081(gene name synonym)|uniprotkb:LDLR chaperone MESD(gene name synonym)|uniprotkb:MESDC2(gene name synonym)|uniprotkb:MESDM(gene name synonym)|uniprotkb:Mesoderm development LRP chaperone MESD(gene name synonym)|uniprotkb:Mesoderm development candidate 2(gene name synonym)|uniprotkb:Mesoderm development protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-61(gene name synonym)|uniprotkb:UNQ1911/PRO4369(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000117899(gene)|ensembl:ENST00000261758(transcript)|ensembl:ENST00000619987(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|ensembl:ENST00000561312(transcript)|go:"GO:0006909"(phagocytosis)|go:"GO:0007498"(mesoderm development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|interpro:IPR019330|mint:Q14696|refseq:NP_055969.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:PO/8DDUMQwmzmwLpGYdFJWIUdB09606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q6DD88 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165882|ensembl:ENSP00000381844|uniprotkb:Q8N7W5|uniprotkb:Q9H8Q5|uniprotkb:Q9UFL1 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:atla3_human(display_long)|uniprotkb:ATL3(gene name)|psi-mi:ATL3(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|mint:Q6DD88|rcsb pdb:5VGR|rcsb pdb:6XJO|go:"GO:0007030"(Golgi organization)|ensembl:ENSG00000184743(gene)|ensembl:ENST00000398868(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001276977.1|refseq:NP_056274.3 psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9vgpZvUg5aFAZyNiZ2pdEPn/J7o9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01733 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-6165888|ensembl:ENSP00000477916|ensembl:ENSP00000487964|uniprotkb:A0A5A7|uniprotkb:A0A0A6YYD5 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tvbl3_human(display_long)|uniprotkb:T-cell receptor beta chain V region YT35(gene name synonym)|uniprotkb:TCRBV12S3(gene name synonym)|uniprotkb:TRBV12-3(gene name)|psi-mi:TRBV12-3(display_short)|uniprotkb:TCRBV8S1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948|ensembl:ENSG00000274752(gene)|ensembl:ENSG00000282208(gene)|ensembl:ENST00000620569(transcript)|ensembl:ENST00000633292(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042287"(MHC protein binding)|go:"GO:0042605"(peptide antigen binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P01733|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427 psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Q1iF+Ih5FyVl9ty4wDJUaAVh/V89606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q13438 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-725454|intact:EBI-1174342|uniprotkb:A6NDD1|uniprotkb:A6NFR7|uniprotkb:A6NLB2|uniprotkb:A8K5Q9|uniprotkb:B4DPX1|uniprotkb:B4E1I6|uniprotkb:E7ENT8|uniprotkb:F8VUH2|uniprotkb:O00579|uniprotkb:Q6IBL2|uniprotkb:Q8IZ58|uniprotkb:Q9BW99|uniprotkb:B4DE28|ensembl:ENSP00000318165|uniprotkb:E7EW91|uniprotkb:G3XA88 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:os9_human(display_long)|uniprotkb:OS9(gene name)|psi-mi:OS9(display_short)|uniprotkb:Amplified in osteosarcoma 9(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006803.1|refseq:NP_001017956.1|refseq:NP_001017957.1|refseq:NP_001017958.1|refseq:NP_001248349.1|refseq:NP_001248350.1|refseq:NP_001248351.1|refseq:NP_001248352.1|ensembl:ENSG00000135506(gene)|ensembl:ENST00000315970(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0002020"(protease binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006605"(protein targeting)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|interpro:IPR044865|rcsb pdb:3AIH|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-37493N psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Ntc3geE7th+rBeIp0MxuUuu/28Y9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q99942 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-348482|ensembl:ENSP00000364235|ensembl:ENSP00000387879|ensembl:ENSP00000388795|ensembl:ENSP00000401172|ensembl:ENSP00000413131|ensembl:ENSP00000415127|ensembl:ENSP00000415784|uniprotkb:A2BFI6|uniprotkb:Q0VDB7|uniprotkb:Q9UMQ2|uniprotkb:B2R4K3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rnf5_human(display_long)|uniprotkb:RNF5(gene name)|psi-mi:RNF5(display_short)|uniprotkb:G16(gene name synonym)|uniprotkb:RING finger protein 5(gene name synonym)|uniprotkb:Protein G16(gene name synonym)|uniprotkb:NG2(gene name synonym)|uniprotkb:RMA1(gene name synonym)|uniprotkb:Ram1 homolog(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_008844.1|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|ensembl:ENST00000456167(transcript)|ensembl:ENSG00000183574(gene)|ensembl:ENSG00000204308(gene)|ensembl:ENSG00000223767(gene)|ensembl:ENSG00000225452(gene)|ensembl:ENSG00000227277(gene)|ensembl:ENSG00000228405(gene)|ensembl:ENSG00000228907(gene)|ensembl:ENST00000375094(transcript)|ensembl:ENST00000413786(transcript)|ensembl:ENST00000432616(transcript)|ensembl:ENST00000445885(transcript)|ensembl:ENST00000449794(transcript)|ensembl:ENST00000453473(transcript)|go:"GO:0055085"(transmembrane transport)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|go:"GO:2000785"(regulation of autophagosome assembly)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|reactome:R-HSA-382556|reactome:R-HSA-5678895|reactome:R-HSA-901032|go:"GO:0044877"(protein-containing complex binding)|dip:DIP-29268N psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eHlCD+xbWmpzFdhVn6OC5MPqeNE9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P61619 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339 psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9NVV0 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1055114|uniprotkb:Q5JR63|uniprotkb:Q5SVN5|uniprotkb:Q5SVN6|uniprotkb:Q5VTE2|uniprotkb:Q6IA97|ensembl:ENSP00000363824 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tm38b_human(display_long)|uniprotkb:Transmembrane protein 38B(gene name synonym)|uniprotkb:C9orf87(gene name synonym)|uniprotkb:TMEM38B(gene name)|psi-mi:TMEM38B(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_060582.1|ensembl:ENSG00000095209(gene)|ensembl:ENST00000374692(transcript)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0060348"(bone development)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR007866(Protein of unknown function DUF714) psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:feIrxCWNpLCnAMaRwBsiKiz2y9w9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P49257 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O94901 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2796904|uniprotkb:B7WP53|uniprotkb:Q9UH98|uniprotkb:Q9HA14|uniprotkb:B7WNY4|uniprotkb:B3KMV7|uniprotkb:Q96CZ7|uniprotkb:B4DZF7|uniprotkb:E9PDU4|uniprotkb:A5PL20|uniprotkb:E9PF23|uniprotkb:F8WD13|ensembl:ENSP00000384015 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sun1_human(display_long)|uniprotkb:KIAA0810(gene name synonym)|uniprotkb:UNC84A(gene name synonym)|uniprotkb:Protein unc-84 homolog A(gene name synonym)|uniprotkb:Sad1/unc-84 protein-like 1(gene name synonym)|uniprotkb:SUN1(gene name)|psi-mi:SUN1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001165416.1|refseq:NP_001124437.1|refseq:NP_001165415.1|refseq:NP_001165417.1|refseq:NP_079430.3|ensembl:ENSG00000164828(gene)|ensembl:ENST00000401592(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051642"(centrosome localization)|go:"GO:0070197"(meiotic attachment of telomere to nuclear envelope)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR018539|interpro:IPR032680|interpro:IPR040994|mint:O94901|rcsb pdb:6R15|rcsb pdb:6R16|rcsb pdb:6R2I|rcsb pdb:7E34|reactome:R-HSA-1221632 psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:RJbLHCT6Gemrj6FLPEGesQcBGjY9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96DZ1 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P04843 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P35232 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q15392 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-5457558|uniprotkb:B7Z817|ensembl:ENSP00000360316|ensembl:ENSP00000416585|uniprotkb:D3DQ51|uniprotkb:Q9HBA8|intact:EBI-10964490 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:dhc24_human(display_long)|uniprotkb:DHCR24(gene name)|psi-mi:DHCR24(display_short)|uniprotkb:KIAA0018(gene name synonym)|uniprotkb:24-dehydrocholesterol reductase(gene name synonym)|uniprotkb:Diminuto/dwarf1 homolog(gene name synonym)|uniprotkb:Seladin-1(gene name synonym)|uniprotkb:3-beta-hydroxysterol Delta-24-reductase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000116133(gene)|ensembl:ENST00000371269(transcript)|ensembl:ENST00000436604(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000246"("delta24(24-1) sterol reductase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0008202"(steroid metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009888"(tissue development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016628"(oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0031639"(plasminogen activation)|go:"GO:0033489"(cholesterol biosynthetic process via desmosterol)|go:"GO:0033490"(cholesterol biosynthetic process via lathosterol)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0050614"(delta24-sterol reductase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061024"(membrane organization)|go:"GO:0071949"(FAD binding)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR006094(FAD linked oxidase, N-terminal)|interpro:IPR016166(FAD-binding, type 2)|interpro:IPR016169(CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2)|interpro:IPR036318|interpro:IPR040165|go:"GO:0005737"(cytoplasm)|mint:Q15392|reactome:R-HSA-6807047|reactome:R-HSA-6807062|refseq:NP_055577.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:kg8bxZHxFFTUmvP9UQMeVFRNWQM9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P08134 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-747589|uniprotkb:Q6ICN3|uniprotkb:B3KSW1|ensembl:ENSP00000285735|ensembl:ENSP00000345236|ensembl:ENSP00000358646|ensembl:ENSP00000358647|ensembl:ENSP00000358651|ensembl:ENSP00000358652|ensembl:ENSP00000358656 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rhoc_human(display_long)|uniprotkb:Rho cDNA clone 9(gene name synonym)|uniprotkb:RHOC(gene name)|psi-mi:RHOC(display_short)|uniprotkb:ARH9(gene name synonym)|uniprotkb:ARHC(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001036143.1|refseq:NP_001036144.1|refseq:NP_786886.1|ensembl:ENSG00000155366(gene)|ensembl:ENST00000285735(transcript)|ensembl:ENST00000339083(transcript)|ensembl:ENST00000369632(transcript)|ensembl:ENST00000369633(transcript)|ensembl:ENST00000369637(transcript)|ensembl:ENST00000369638(transcript)|ensembl:ENST00000369642(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032420"(stereocilium)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902766"(skeletal muscle satellite cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P08134|rcsb pdb:1Z2C|rcsb pdb:2GCN|rcsb pdb:2GCO|rcsb pdb:2GCP|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013106 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:CPt/q5soDZILGfkngD41Y1U4eys9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q92598 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-356829|uniprotkb:O95739|uniprotkb:Q5TBM6|uniprotkb:Q5TBM8|uniprotkb:Q9UPC4|uniprotkb:Q5TBM7|intact:EBI-2859494|uniprotkb:B4DYH1|ensembl:ENSP00000318687 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hs105_human(display_long)|uniprotkb:HSPH1(gene name)|psi-mi:HSPH1(display_short)|uniprotkb:HSP105(gene name synonym)|uniprotkb:HSP110(gene name synonym)|uniprotkb:KIAA0201(gene name synonym)|uniprotkb:Heat shock 110 kDa protein(gene name synonym)|uniprotkb:Antigen NY-CO-25(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001273432.1|refseq:NP_001273433.1|refseq:NP_001273434.1|refseq:NP_006635.2|ensembl:ENSG00000120694(gene)|ensembl:ENST00000320027(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042053|interpro:IPR043129|mint:Q92598|rcsb pdb:6GFA|reactome:R-HSA-3000484|reactome:R-HSA-3371453 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:FSdvp2KDHLmNpceRJ9HLY5IBfQA9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P07339 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2115097|uniprotkb:Q6IB57|ensembl:ENSP00000236671 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:catd_human(display_long)|uniprotkb:CTSD(gene name)|psi-mi:CTSD(display_short)|uniprotkb:CPSD(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001900.1|dip:DIP-43906N|ensembl:ENSG00000117984(gene)|ensembl:ENST00000236671(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070001"(aspartic-type peptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR001461(Peptidase A1)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR012848(Propeptide, peptidase A1)|interpro:IPR021109|interpro:IPR033121|interpro:IPR033144|mint:P07339|rcsb pdb:1LYA|rcsb pdb:1LYB|rcsb pdb:1LYW|rcsb pdb:4OBZ|rcsb pdb:4OC6|rcsb pdb:4OD9|reactome:R-HSA-1442490|reactome:R-HSA-2022377|reactome:R-HSA-2132295|reactome:R-HSA-6798695|reactome:R-HSA-9018519 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:M1qLQBlL2DSCZiAwIPee9Vza3dU9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9Y287 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2866431|uniprotkb:Q5W0A3|uniprotkb:Q96B24|uniprotkb:Q9NYH1|ensembl:ENSP00000497221 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:itm2b_human(display_long)|uniprotkb:ITM2B(gene name)|psi-mi:ITM2B(display_short)|uniprotkb:BRI(gene name synonym)|uniprotkb:BRI2(gene name synonym)|uniprotkb:Protein E25B(gene name synonym)|uniprotkb:Transmembrane protein BRI(gene name synonym)|uniprotkb:Immature BRI2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_068839.1|ensembl:ENSG00000136156(gene)|ensembl:ENST00000647800(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0030660"(Golgi-associated vesicle membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0042985"(negative regulation of amyloid precursor protein biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007084(BRICHOS)|interpro:IPR040145|reactome:R-HSA-977225 psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:9mHhC4Z61CsmOsTh/1K9oj2NezA9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q15782 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2873481|ensembl:ENSP00000358763|ensembl:ENSP00000437082|uniprotkb:Q96F97|uniprotkb:Q5VUV7|uniprotkb:Q15783|uniprotkb:Q15749|uniprotkb:B4DPR7|uniprotkb:A6NNY3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ch3l2_human(display_long)|uniprotkb:CHI3L2(gene name)|psi-mi:CHI3L2(display_short)|uniprotkb:Chondrocyte protein 39(gene name synonym)|uniprotkb:YKL-39(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000064886(gene)|ensembl:ENST00000369748(transcript)|ensembl:ENST00000445067(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006032"(chitin catabolic process)|go:"GO:0008061"(chitin binding)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030246"(carbohydrate binding)|interpro:IPR001223(Glycoside hydrolase, family 18, catalytic domain)|interpro:IPR011583(Chitinase II)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028541|interpro:IPR029070|rcsb pdb:4AY1|rcsb pdb:4P8U|rcsb pdb:4P8V|rcsb pdb:4P8W|rcsb pdb:4P8X|refseq:NP_001020368.1|refseq:NP_001020370.1|refseq:NP_003991.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:/wNVpBug4/Q2QEQI3lDgW7PX6po9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q93084 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1046185|uniprotkb:O60900|uniprotkb:O60901|uniprotkb:O75501|uniprotkb:O75502|uniprotkb:Q16115|uniprotkb:Q8TEX5|uniprotkb:Q8TEX6|uniprotkb:D3DTJ8|uniprotkb:A8MZG0|uniprotkb:Q6JHX1|ensembl:ENSP00000380234 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:at2a3_human(display_long)|uniprotkb:Calcium pump 3(gene name synonym)|uniprotkb:ATP2A3(gene name)|psi-mi:ATP2A3(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_777618.1|refseq:NP_005164.2|refseq:NP_777615.1|refseq:NP_777616.1|refseq:NP_777617.1|refseq:NP_777613.1|refseq:NP_777614.1|ensembl:ENSG00000074370(gene)|ensembl:ENST00000397041(transcript)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030899"(calcium-dependent ATPase activity)|go:"GO:0031090"(organelle membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Nvh6pdcL5m05Wgu5rINDl8bhvDM9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P14314 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O00264 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96EE3 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025 psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q12907 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-3915406|uniprotkb:Q53HH1|ensembl:ENSP00000303366 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman2_human(display_long)|uniprotkb:LMAN2(gene name)|psi-mi:LMAN2(display_short)|uniprotkb:C5orf8(gene name synonym)|uniprotkb:Glycoprotein GP36b(gene name synonym)|uniprotkb:Lectin mannose-binding 2(gene name synonym)|uniprotkb:Vesicular integral-membrane protein 36(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006807.1|ensembl:ENSG00000169223(gene)|ensembl:ENST00000303127(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035664|mint:Q12907|reactome:R-HSA-204005|reactome:R-HSA-5694530 psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:goqUZGW9/lvVMWDAZS9csH3TqWY9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q96RQ1 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-4403663|uniprotkb:A6NHH6|uniprotkb:Q53GY2|uniprotkb:Q8N2Q9|uniprotkb:Q9BVV9|uniprotkb:Q9NZA3|ensembl:ENSP00000353270 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ergi2_human(display_long)|uniprotkb:ERGIC2(gene name)|psi-mi:ERGIC2(display_short)|uniprotkb:ERV41(gene name synonym)|uniprotkb:PTX1(gene name synonym)|uniprotkb:CDA14(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_057654.2|ensembl:ENSG00000087502(gene)|ensembl:ENST00000360150(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:+T1RODVKNyboKSh3evzH0SZUm7s9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBS4 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-713113|ensembl:ENSP00000265028|ensembl:ENSP00000414398|uniprotkb:Q542Y5|uniprotkb:Q542Y9|uniprotkb:Q6IAQ8|uniprotkb:Q96JC6 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:djb11_human(display_long)|uniprotkb:HDJ9(gene name synonym)|uniprotkb:DnaJ protein homolog 9(gene name synonym)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:HEDJ(gene name synonym)|uniprotkb:Human DnaJ protein 9(gene name synonym)|uniprotkb:PWP1-interacting protein 4(gene name synonym)|uniprotkb:APOBEC1-binding protein 2(gene name synonym)|uniprotkb:PSEC0121(orf name)|uniprotkb:DNAJB11(gene name)|psi-mi:DNAJB11(display_short)|uniprotkb:EDJ(gene name synonym)|uniprotkb:ERJ3(gene name synonym)|uniprotkb:UNQ537/PRO1080(orf name)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000090520(gene)|ensembl:ENST00000265028(transcript)|ensembl:ENST00000439351(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0016020"(membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q9UBS4|reactome:R-HSA-381038|go:"GO:0006457"(protein folding)|refseq:NP_057390.1|dip:DIP-29678N psi-mi:"MI:0096"(pull down) - author-confidence:0.96 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:B8jV6uvPmoGzOEpe4qrMiYloSok9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9UBV2 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0096"(pull down) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P43629 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-3910993|uniprotkb:Q16541|uniprotkb:O43473|uniprotkb:Q14946|ensembl:ENSP00000375608|ensembl:ENSP00000492794|ensembl:ENSP00000484036|ensembl:ENSP00000484488|ensembl:ENSP00000484972|ensembl:ENSP00000491550 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ki3l1_human(display_long)|uniprotkb:KIR3DL1(gene name)|psi-mi:KIR3DL1(display_short)|uniprotkb:CD158E(gene name synonym)|uniprotkb:NKAT3(gene name synonym)|uniprotkb:NKB1(gene name synonym)|uniprotkb:CD158 antigen-like family member E(gene name synonym)|uniprotkb:HLA-BW4-specific inhibitory NK cell receptor(gene name synonym)|uniprotkb:MHC class I NK cell receptor(gene name synonym)|uniprotkb:Natural killer-associated transcript 3(gene name synonym)|uniprotkb:p70 natural killer cell receptor clones CL-2/CL-11(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_037421.2|refseq:NP_001309097.1|ensembl:ENSG00000167633(gene)|ensembl:ENSG00000274036(gene)|ensembl:ENSG00000275288(gene)|ensembl:ENSG00000276423(gene)|ensembl:ENSG00000284342(gene)|ensembl:ENSG00000284426(gene)|ensembl:ENST00000391728(transcript)|ensembl:ENST00000612668(transcript)|ensembl:ENST00000616188(transcript)|ensembl:ENST00000621353(transcript)|ensembl:ENST00000639353(transcript)|ensembl:ENST00000640788(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0030109"(HLA-B specific inhibitory MHC class I receptor activity)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:3VH8|rcsb pdb:3WUW|rcsb pdb:5B38|rcsb pdb:5B39|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:6V3J|rcsb pdb:7K80|reactome:R-HSA-198933 psi-mi:"MI:0096"(pull down) - author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:hmkzMYVXr2As+kkOTVcl5L262l09606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q13112 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1052944|uniprotkb:Q99548|ensembl:ENSP00000315700 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:caf1b_human(display_long)|uniprotkb:Chromatin assembly factor I p60 subunit(gene name synonym)|uniprotkb:M-phase phosphoprotein 7(gene name synonym)|uniprotkb:CHAF1B(gene name)|psi-mi:CHAF1B(display_short)|uniprotkb:CAF1A(gene name synonym)|uniprotkb:CAF1P60(gene name synonym)|uniprotkb:MPHOSPH7(gene name synonym)|uniprotkb:MPP7(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_005432.1|dip:DIP-29243N|ensembl:ENSG00000159259(gene)|ensembl:ENST00000314103(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0007049"(cell cycle)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR029129|interpro:IPR036322|mint:Q13112|refseq:XP_016883966.1|refseq:XP_016883967.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:VVbW9mpUGYMRPxvlEk9FERHIsJs9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9NYU2 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 psi-mi:"MI:0096"(pull down) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9HCN8 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2339921|uniprotkb:Q9BRI5|uniprotkb:A2RUD3|ensembl:ENSP00000248958 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2l_human(display_long)|uniprotkb:SDF2L1(gene name)|psi-mi:SDF2L1(display_short)|uniprotkb:PWP1-interacting protein 8(gene name synonym)|uniprotkb:UNQ1941/PRO4424(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_071327.2|ensembl:ENSG00000128228(gene)|ensembl:ENST00000248958(transcript)|go:"GO:0004169"(dolichyl-phosphate-mannose-protein mannosyltransferase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0035269"(protein O-linked mannosylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|mint:Q9HCN8 psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:0vAPKCqCGpCARkmy7ZsTccxScgk9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:O14967 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-3907005|uniprotkb:D3DNY8|uniprotkb:B3KS90|uniprotkb:B4DXV8|ensembl:ENSP00000326699|ensembl:ENSP00000392782 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:clgn_human(display_long)|uniprotkb:CLGN(gene name)|psi-mi:CLGN(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001124147.1|refseq:NP_004353.1|ensembl:ENSG00000153132(gene)|ensembl:ENST00000325617(transcript)|ensembl:ENST00000414773(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007338"(single fertilization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:O14967 psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Akb2XoiNjob34njC2erE11yg80w9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P30101 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q8TCT9 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-347472|uniprotkb:Q540H8|uniprotkb:Q5JWP2|uniprotkb:Q5JWP3|uniprotkb:Q5JWP4|uniprotkb:Q5JWP5|uniprotkb:Q7Z4F2|uniprotkb:Q86Y35|uniprotkb:Q95H87|uniprotkb:Q9H110|uniprotkb:Q9H111|uniprotkb:Q15K36|uniprotkb:B2RAY5|uniprotkb:E1P5L3|ensembl:ENSP00000343032 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hm13_human(display_long)|uniprotkb:HM13(gene name)|psi-mi:HM13(display_short)|uniprotkb:H13(gene name synonym)|uniprotkb:PSL3(gene name synonym)|uniprotkb:SPP(gene name synonym)|uniprotkb:Signal peptide peptidase(gene name synonym)|uniprotkb:Presenilin-like protein 3(gene name synonym)|uniprotkb:Intramembrane protease 1(gene name synonym)|uniprotkb:IMP1(gene name synonym)|uniprotkb:MSTP086(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_110416.1|refseq:NP_848695.1|refseq:NP_848696.1|refseq:NP_848697.1|ensembl:ENSG00000101294(gene)|ensembl:ENST00000340852(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0061960"(regulation of heme oxygenase activity)|go:"GO:0071458"(integral component of cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR007369(Peptidase A22B, signal peptide peptidase)|reactome:R-HSA-9707587 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:DxNjJDcc+zomfXAj0TEaByKeNqc9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9Y282 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-781551|uniprotkb:Q6ZWP7|uniprotkb:Q9H276|uniprotkb:Q9P1L3|uniprotkb:Q5JWS3|ensembl:ENSP00000341358 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ergi3_human(display_long)|uniprotkb:Serologically defined breast cancer antigen NY-BR-84(gene name synonym)|uniprotkb:ERGIC3(gene name)|psi-mi:ERGIC3(display_short)|uniprotkb:C20orf47(gene name synonym)|uniprotkb:CGI-54(orf name)|uniprotkb:PRO0989(orf name)|uniprotkb:ERV46(gene name synonym)|uniprotkb:SDBCAG84(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_057050.1|refseq:NP_938408.1|ensembl:ENSG00000125991(gene)|ensembl:ENST00000348547(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542|mint:Q9Y282 psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:LllzE6k0eaM1uUJGjkieiPARw149606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P27797 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1049597|uniprotkb:Q6IAT4|uniprotkb:Q9UDG2|ensembl:ENSP00000320866|ensembl:ENSP00000466037 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:calr_human(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:grp60(gene name synonym)|uniprotkb:CALR(gene name)|psi-mi:CALR(display_short)|uniprotkb:CRTC(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_004334.1|ensembl:ENSG00000179218(gene)|ensembl:ENST00000316448(transcript)|ensembl:ENST00000586967(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022417"(protein maturation by protein folding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P27797|rcsb pdb:2CLR|rcsb pdb:3DOW|rcsb pdb:3POS|rcsb pdb:3POW|rcsb pdb:5LK5|rcsb pdb:5V90|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-168316|reactome:R-HSA-3000480|reactome:R-HSA-3000484|reactome:R-HSA-381183|reactome:R-HSA-901042|reactome:R-HSA-983170|dip:DIP-104N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:FSPSiiN6YTaETDyAWwAP3wV6zRI9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q99470 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P05107 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-300173|ensembl:ENSP00000303242|ensembl:ENSP00000347279|ensembl:ENSP00000380948|ensembl:ENSP00000380950|ensembl:ENSP00000380955|uniprotkb:Q16418|uniprotkb:B3KTS8|uniprotkb:Q53HS5|uniprotkb:Q9UD72|uniprotkb:D3DSM1 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:itb2_human(display_long)|uniprotkb:ITGB2(gene name)|psi-mi:ITGB2(display_short)|uniprotkb:CD18(gene name synonym)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:MFI7(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008305"(integrin complex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0034689"(integrin alphaX-beta2 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043113"(receptor clustering)|ensembl:ENSG00000160255(gene)|ensembl:ENST00000302347(transcript)|ensembl:ENST00000355153(transcript)|ensembl:ENST00000397850(transcript)|ensembl:ENST00000397852(transcript)|ensembl:ENST00000397857(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:0045963"(negative regulation of dopamine metabolic process)|go:"GO:1990266"(neutrophil migration)|go:"GO:2000363"(positive regulation of prostaglandin-E synthase activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|go:"GO:0046872"(metal ion binding)|interpro:IPR036465|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|mint:P05107|rcsb pdb:1JX3|rcsb pdb:1L3Y|rcsb pdb:1YUK|go:"GO:0050839"(cell adhesion molecule binding)|rcsb pdb:2JF1|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2P26|rcsb pdb:2P28|rcsb pdb:2V7D|rcsb pdb:3K6S|rcsb pdb:3K71|rcsb pdb:3K72|go:"GO:0070821"(tertiary granule membrane)|rcsb pdb:4NEH|rcsb pdb:4NEN|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|rcsb pdb:5E6R|rcsb pdb:5E6S|rcsb pdb:5E6U|rcsb pdb:5E6V|rcsb pdb:5E6W|rcsb pdb:5E6X|rcsb pdb:5ES4|rcsb pdb:5XR1|rcsb pdb:5ZAZ|reactome:R-HSA-166016|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-6785807|reactome:R-HSA-6798695|refseq:NP_000202.3|refseq:NP_001120963.2|refseq:NP_001290167.1|dip:DIP-478N psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:aaycm8Q/rmu01cs20dw399oJjFE9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q14697 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-348004|ensembl:ENSP00000349053|uniprotkb:A6NC20|uniprotkb:Q8WTS9|uniprotkb:Q9P0X0 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ganab_human(display_long)|uniprotkb:GANAB(gene name)|psi-mi:GANAB(display_short)|uniprotkb:G2AN(gene name synonym)|uniprotkb:KIAA0088(gene name synonym)|uniprotkb:Glucosidase II subunit alpha(gene name synonym)|uniprotkb:Alpha-glucosidase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC ensembl:ENSG00000089597(gene)|ensembl:ENST00000356638(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004553"(hydrolase activity, hydrolyzing O-glycosyl compounds)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006491"(N-glycan processing)|go:"GO:0016020"(membrane)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0033919"(glucan 1,3-alpha-glucosidase activity)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090599"(alpha-glucosidase activity)|interpro:IPR000322(Glycoside hydrolase, family 31)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR025887|interpro:IPR030458|interpro:IPR030459|mint:Q14697|reactome:R-HSA-532668|reactome:R-HSA-901042|reactome:R-HSA-9694548|reactome:R-HSA-9683686|refseq:NP_938148.1|refseq:NP_938149.2|refseq:NP_001265121.1|refseq:NP_001265122.1|refseq:NP_001265123.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:663u1GYwNTZrodoVqwzFjSDGCqs9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01850 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1034839|uniprotkb:A0A5B8|uniprotkb:A6NH51|uniprotkb:A0A0J9YYE9 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:trbc1_human(display_long)|uniprotkb:TRBC1(gene name)|psi-mi:TRBC1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC rcsb pdb:4L9L|rcsb pdb:4LCC|rcsb pdb:4LCW|rcsb pdb:4MNQ|rcsb pdb:3D3V|rcsb pdb:4NQC|rcsb pdb:4NQD|rcsb pdb:4NQE|rcsb pdb:4OZF|rcsb pdb:4OZG|rcsb pdb:4OZH|rcsb pdb:4OZI|rcsb pdb:4PRH|rcsb pdb:4PRI|rcsb pdb:4PRP|rcsb pdb:3D39|rcsb pdb:3HE6|rcsb pdb:3KPR|rcsb pdb:4GG6|rcsb pdb:4GG8|rcsb pdb:4L4V|rcsb pdb:2BNQ|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003597(Immunoglobulin C1-set)|rcsb pdb:1FYT|rcsb pdb:1J8H|rcsb pdb:1KGC|rcsb pdb:1KTK|rcsb pdb:1MI5|rcsb pdb:1OGA|rcsb pdb:1YMM|rcsb pdb:1ZGL|rcsb pdb:2AK4|rcsb pdb:2AXH|rcsb pdb:2BNR|rcsb pdb:2BNU|rcsb pdb:2ESV|rcsb pdb:2F53|rcsb pdb:2F54|rcsb pdb:2GJ6|rcsb pdb:2IAL|rcsb pdb:2IAM|rcsb pdb:2IAN|rcsb pdb:2NTS|rcsb pdb:2NW2|rcsb pdb:2NX5|rcsb pdb:2P5E|rcsb pdb:2P5W|rcsb pdb:2PO6|rcsb pdb:2PYE|rcsb pdb:2PYF|rcsb pdb:2VLJ|rcsb pdb:2VLK|rcsb pdb:2VLM|rcsb pdb:2VLR|rcsb pdb:2XN9|rcsb pdb:2XNA|rcsb pdb:3DX9|rcsb pdb:3DXA|rcsb pdb:3FFC|rcsb pdb:4ZDH|go:"GO:0003823"(antigen binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|rcsb pdb:4G8E|rcsb pdb:4G8F|rcsb pdb:4IIQ|rcsb pdb:4JRX|rcsb pdb:4JRY|rcsb pdb:4MJI|rcsb pdb:4P46|rcsb pdb:4X6B|rcsb pdb:4X6C|rcsb pdb:4X6D|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948|rcsb pdb:4JFD|rcsb pdb:4JFE|rcsb pdb:4JFF|rcsb pdb:4JFH|rcsb pdb:2CDE|rcsb pdb:2CDF|rcsb pdb:2CDG|rcsb pdb:3ARB|rcsb pdb:3ARD|rcsb pdb:3ARE|rcsb pdb:3ARF|rcsb pdb:3ARG|rcsb pdb:3O4L|rcsb pdb:1AO7|rcsb pdb:3HG1|rcsb pdb:3KPS|rcsb pdb:3TN0|rcsb pdb:4L4T|interpro:IPR036179 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:tLvWuE6FRB59QPlPL99jKQFkiuQ9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P16615 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-358933|uniprotkb:P16614|uniprotkb:A6NDN7|uniprotkb:B4DF05|uniprotkb:Q86VJ2|ensembl:ENSP00000440045 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:at2a2_human(display_long)|uniprotkb:ATP2A2(gene name)|psi-mi:ATP2A2(display_short)|uniprotkb:ATP2B(gene name synonym)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001672.1|refseq:NP_733765.1|refseq:XP_011536704.1|ensembl:ENSG00000174437(gene)|ensembl:ENST00000539276(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0007155"(cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008544"(epidermis development)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P16615|rcsb pdb:5ZTF|rcsb pdb:6JJU|rcsb pdb:6LLE|rcsb pdb:6LLY|rcsb pdb:6LN5|rcsb pdb:6LN6|rcsb pdb:6LN7|rcsb pdb:6LN8|rcsb pdb:6LN9|rcsb pdb:7BT2|reactome:R-HSA-1912420|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|go:"GO:0000045"(autophagosome assembly)|refseq:XP_005253945.1|dip:DIP-33868N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:QlJZW2fprLYahKUrHDOVs28kA2w9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9BUV8 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1050079|uniprotkb:O00605|uniprotkb:Q9BT03|uniprotkb:Q9BZU7|uniprotkb:Q9UI05|uniprotkb:Q5QPG7|uniprotkb:E1P5U0|uniprotkb:Q5QPG6|ensembl:ENSP00000362958 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rcaf1_human(display_long)|uniprotkb:Rab5-interacting protein(gene name synonym)|uniprotkb:RAB5IF(gene name)|psi-mi:RAB5IF(display_short)|uniprotkb:C20orf24(gene name synonym)|uniprotkb:PNAS-11(orf name)|uniprotkb:RCAF1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001186463.1|refseq:NP_061328.1|refseq:NP_955777.1|ensembl:ENSG00000101084(gene)|ensembl:ENST00000373852(transcript)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0016021"(integral component of membrane)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR010742(Rab5-interacting)|interpro:IPR029008 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:N4IzJ4zGbfRBmazjtTZ6eMIhKqE9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P01130 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-988319|uniprotkb:Q53ZD9|ensembl:ENSP00000454071|uniprotkb:C0JYY8|uniprotkb:Q9UDH7|uniprotkb:B4DJZ8|uniprotkb:B4DR00|uniprotkb:B4DTQ3|uniprotkb:H0YLU8|uniprotkb:Q59FQ1|uniprotkb:B4DII3|uniprotkb:H0YNT7 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ldlr_human(display_long)|uniprotkb:LDLR(gene name)|psi-mi:LDLR(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_000518.1|ensembl:ENSG00000130164(gene)|ensembl:ENST00000558518(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002020"(protease binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070508"(cholesterol import)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|go:"GO:0030169"(low-density lipoprotein particle binding)|interpro:IPR036055|rcsb pdb:1AJJ|rcsb pdb:1D2J|rcsb pdb:1F5Y|rcsb pdb:1F8Z|rcsb pdb:1HJ7|rcsb pdb:1HZ8|rcsb pdb:1I0U|rcsb pdb:1IJQ|rcsb pdb:1LDL|mint:P01130|rcsb pdb:1LDR|rcsb pdb:1LRX|rcsb pdb:1N7D|rcsb pdb:1XFE|rcsb pdb:2FCW|rcsb pdb:2KRI|rcsb pdb:2LGP|rcsb pdb:2M7P|rcsb pdb:2MG9|rcsb pdb:2W2N|rcsb pdb:2W2O|rcsb pdb:2W2P|rcsb pdb:2W2Q|rcsb pdb:3BPS|rcsb pdb:3GCW|rcsb pdb:3GCX|rcsb pdb:3M0C|rcsb pdb:3P5B|rcsb pdb:3P5C|rcsb pdb:3SO6|rcsb pdb:4NE9|rcsb pdb:5OY9|rcsb pdb:5OYL|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8964026|reactome:R-HSA-8964038|reactome:R-HSA-975634|rcsb pdb:2W2M|refseq:NP_001182732.1|refseq:NP_001182728.1|refseq:NP_001182729.1|refseq:NP_001182727.1|dip:DIP-29695N psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:90JtkJet79Lm8v1cD6ggYERSrEM9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9H3P7 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1791792|uniprotkb:Q5VTJ0|uniprotkb:Q6P9F1|uniprotkb:Q8IZC5|uniprotkb:Q8N4D6|uniprotkb:Q9H6U3|uniprotkb:B2RB29|ensembl:ENSP00000355777 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:gcp60_human(display_long)|uniprotkb:GOCAP1(gene name synonym)|uniprotkb:GOLPH1(gene name synonym)|uniprotkb:ACBD3(gene name)|psi-mi:ACBD3(display_short)|uniprotkb:GCP60(gene name synonym)|uniprotkb:Acyl-CoA-binding domain-containing protein 3(gene name synonym)|uniprotkb:Golgi phosphoprotein 1(gene name synonym)|uniprotkb:Golgi complex-associated protein 1(gene name synonym)|uniprotkb:PBR- and PKA-associated protein 7(gene name synonym)|uniprotkb:Peripheral benzodiazepine receptor-associated protein PAP7(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_073572.2|dip:DIP-40673N|ensembl:ENSG00000182827(gene)|ensembl:ENST00000366812(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR009038(GOLD)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR022408|interpro:IPR035984|interpro:IPR036598|mint:Q9H3P7|rcsb pdb:2N72|rcsb pdb:2N73|rcsb pdb:5LZ1|rcsb pdb:5LZ3|rcsb pdb:5LZ6|rcsb pdb:5TDQ|rcsb pdb:6HLN|rcsb pdb:6HLT|rcsb pdb:6HLV|rcsb pdb:6HLW|rcsb pdb:6HM8|rcsb pdb:6HMV|reactome:R-HSA-432722 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:jAaMXnoXG6RGj+lAgIYk1inXA6o9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q9BXS5 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-541426|ensembl:ENSP00000291439|uniprotkb:Q4TTY5 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ap1m1_human(display_long)|uniprotkb:Golgi adaptor HA1/AP1 adaptin mu-1 subunit(gene name synonym)|uniprotkb:Mu-adaptin 1(gene name synonym)|uniprotkb:AP-mu chain family member mu1A(gene name synonym)|uniprotkb:Mu1A-adaptin(gene name synonym)|uniprotkb:Clathrin coat assembly protein AP47(gene name synonym)|uniprotkb:Clathrin coat-associated protein AP47(gene name synonym)|uniprotkb:Adaptor protein complex AP-1 subunit mu-1(gene name synonym)|uniprotkb:Clathrin assembly protein complex 1 mu-1 medium chain 1(gene name synonym)|uniprotkb:AP1M1(gene name)|psi-mi:AP1M1(display_short)|uniprotkb:CLTNM(gene name synonym)|uniprotkb:Adaptor-related protein complex 1 subunit mu-1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_115882.1|ensembl:ENSG00000072958(gene)|ensembl:ENST00000291439(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032438"(melanosome organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR028565|interpro:IPR036168|mint:Q9BXS5|reactome:R-HSA-164940|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001123996.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:B6OVovdusOdmvB0D+RIyhRRga2Q9606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:Q07065 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578 uniprotkb:P51571 intact:EBI-6163496|uniprotkb:O09779 intact:EBI-1054539|uniprotkb:Q53XY1|uniprotkb:A8K378|ensembl:ENSP00000317331|ensembl:ENSP00000359103|ensembl:ENSP00000359104 psi-mi:env_hv1h2(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ssrd_human(display_long)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)|uniprotkb:SSR4(gene name)|psi-mi:SSR4(display_short)|uniprotkb:TRAPD(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177436|imex:IM-17346-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057856.1|dip:DIP-58525N|reactome:R-HSA-1462054|reactome:R-HSA-162588|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-5621480|go:"GO:0005198"(structural molecule activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044423"(virion component)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|go:"GO:1903908"(positive regulation of plasma membrane raft polarization)|go:"GO:1903911"(positive regulation of receptor clustering)|interpro:IPR000328(Envelope Polyprotein GP41)|interpro:IPR000777(Envelope glycoprotein GP120)|interpro:IPR036377|interpro:IPR037527|rcsb pdb:1AIK|rcsb pdb:1DF4|rcsb pdb:1DF5|rcsb pdb:1DLB|rcsb pdb:1FAV|rcsb pdb:1G9M|rcsb pdb:1GC1|rcsb pdb:1GZL|rcsb pdb:1K33|rcsb pdb:1K34|rcsb pdb:1MZI|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1RZJ|rcsb pdb:2CMR|rcsb pdb:2ME1|rcsb pdb:2MG1|rcsb pdb:2MG2|rcsb pdb:2MG3|rcsb pdb:2NY7|rcsb pdb:2PV6|rcsb pdb:2XRA|rcsb pdb:3D0V|rcsb pdb:3DNL|rcsb pdb:3DNN|rcsb pdb:3DNO|rcsb pdb:3DRO|rcsb pdb:3IDX|rcsb pdb:3IDY|rcsb pdb:3J70|rcsb pdb:3MNZ|rcsb pdb:3TYG|rcsb pdb:3VIE|rcsb pdb:4JPJ|rcsb pdb:4JPK|rcsb pdb:4YDV|rcsb pdb:4ZTO|rcsb pdb:5BN0|rcsb pdb:5C0R|rcsb pdb:5C0S|rcsb pdb:5CIL|rcsb pdb:5CIN|rcsb pdb:5CMU|rcsb pdb:5CMZ|rcsb pdb:5CN0|rcsb pdb:5DD0|rcsb pdb:5GHW|rcsb pdb:5H0N|rcsb pdb:5HFL|rcsb pdb:5HM1|rcsb pdb:5IVX|rcsb pdb:5KA5|rcsb pdb:5KA6|rcsb pdb:5NVP|rcsb pdb:5NWU|rcsb pdb:5NWW|rcsb pdb:5TKJ|rcsb pdb:5TKK|rcsb pdb:5WDF|rcsb pdb:5X08|rcsb pdb:5YB2|rcsb pdb:5YB3|rcsb pdb:5YB4|rcsb pdb:5YC0|rcsb pdb:5Z0W|rcsb pdb:5ZCX|rcsb pdb:6B9K|rcsb pdb:6BXP|rcsb pdb:6BXQ|rcsb pdb:6DE7|rcsb pdb:6DLN|rcsb pdb:6J5E|rcsb pdb:6JQK|rcsb pdb:6KTS|rcsb pdb:6MQC|rcsb pdb:6MQE|rcsb pdb:6MQM|rcsb pdb:6MQR|rcsb pdb:6MQS|rcsb pdb:6N16|rcsb pdb:6NCP|rcsb pdb:6NPR|rcsb pdb:6O3G|rcsb pdb:6O3J|rcsb pdb:6O3L|rcsb pdb:6O42|rcsb pdb:6P60|rcsb pdb:6P7H|rcsb pdb:6P8D|rcsb pdb:6PDR|rcsb pdb:6PDS|rcsb pdb:6PDU|rcsb pdb:6PEC|rcsb pdb:6PEF|rcsb pdb:6PSA|rcsb pdb:6RYF|rcsb pdb:6SNC|rcsb pdb:6SND|rcsb pdb:6SNE|rcsb pdb:6UBI|rcsb pdb:6UCE|rcsb pdb:6UCF|rcsb pdb:6UJU|rcsb pdb:6UJV|rcsb pdb:6WWC refseq:NP_001191455.1|refseq:NP_006271.1|refseq:XP_011529488.1|refseq:XP_011529489.1|ensembl:ENSG00000180879(gene)|ensembl:ENST00000320857(transcript)|ensembl:ENST00000370086(transcript)|ensembl:ENST00000370087(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008855(Translocon-associated)|mint:P51571|reactome:R-HSA-1799339 psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2021/11/30 rogid:0cs6c9Wi6DV3vHjKBSlqRJ8keHk11706 rogid:2SNgZQH/jwi61UcuHUf7RYKZH589606 intact-crc:77C4F565AC64E37F|rigid:GWfDVs6IsTdXFW9hlOfOzw28g5U false mutation:53-53,94-94,192-192,215-215,224-224,346-346,470-470,580-580("MI:0118")|tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96IV0 intact:EBI-6179711 intact:EBI-6165879|ensembl:ENSP00000280700|uniprotkb:B4DJE9|uniprotkb:Q59FB1|uniprotkb:Q6PJD8|uniprotkb:Q9BVR8|uniprotkb:Q9NR70 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:ngly1_human(display_long)|uniprotkb:NGLY1(gene name)|psi-mi:NGLY1(display_short)|uniprotkb:N-glycanase 1(gene name synonym)|uniprotkb:PNG1(gene name synonym)|uniprotkb:"Peptide:N-glycanase"(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000151092(gene)|ensembl:ENST00000280700(transcript)|go:"GO:0000224"("peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR006588(Protein of unknown function PAW)|interpro:IPR008979(Galactose-binding like)|interpro:IPR018997|interpro:IPR036339|interpro:IPR038680|interpro:IPR038765|mint:Q96IV0|rcsb pdb:2CCQ|rcsb pdb:2CM0|reactome:R-HSA-532668|refseq:NP_001138767.1|refseq:NP_060767.2|refseq:NP_001138765.1|refseq:NP_001138766.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CujOKLkvqxGmWpFvJM3B894PHqc9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O94919 intact:EBI-6179711 intact:EBI-6163734|ensembl:ENSP00000278505|uniprotkb:Q8TAQ8|uniprotkb:Q6GQY5|uniprotkb:A8K6K8 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:endd1_human(display_long)|uniprotkb:ENDOD1(gene name)|psi-mi:ENDOD1(display_short)|uniprotkb:KIAA0830(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000149218(gene)|ensembl:ENST00000278505(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001604(DNA/RNA non-specific endonuclease)|interpro:IPR020821|interpro:IPR039015|reactome:R-HSA-114608|refseq:NP_055851.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Y1gEFK1zb6sij3QwLSrq9t4zQLU9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P61009 intact:EBI-6179711 intact:EBI-6166040|ensembl:ENSP00000427463|uniprotkb:P12280|uniprotkb:Q9H0S7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:spcs3_human(display_long)|uniprotkb:SPCS3(gene name)|psi-mi:SPCS3(display_short)|uniprotkb:Microsomal signal peptidase 22/23 kDa subunit(gene name synonym)|uniprotkb:SPC22(gene name synonym)|uniprotkb:UNQ1841/PRO3567(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000129128(gene)|ensembl:ENST00000503362(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019082"(viral protein processing)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR007653(Signal peptidase 22 kDa subunit)|mint:P61009|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085|refseq:NP_068747.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:IJjfzKRjeZefoy2znnC4XC6wgOU9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q6DD88 intact:EBI-6179711 intact:EBI-6165882|ensembl:ENSP00000381844|uniprotkb:Q8N7W5|uniprotkb:Q9H8Q5|uniprotkb:Q9UFL1 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:atla3_human(display_long)|uniprotkb:ATL3(gene name)|psi-mi:ATL3(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:1903373"(positive regulation of endoplasmic reticulum tubular network organization)|interpro:IPR003191(Guanylate-binding protein, C-terminal)|interpro:IPR015894(Guanylate-binding protein, N-terminal)|interpro:IPR027417|interpro:IPR030386|interpro:IPR036543|mint:Q6DD88|rcsb pdb:5VGR|rcsb pdb:6XJO|go:"GO:0007030"(Golgi organization)|ensembl:ENSG00000184743(gene)|ensembl:ENST00000398868(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_001276977.1|refseq:NP_056274.3 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:9vgpZvUg5aFAZyNiZ2pdEPn/J7o9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q99623 intact:EBI-6179711 intact:EBI-358348|uniprotkb:Q2YDA4|uniprotkb:Q7KYU3|uniprotkb:Q92978|ensembl:ENSP00000441875|uniprotkb:B4DP75 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb2_human(display_long)|uniprotkb:BAP(gene name synonym)|uniprotkb:REA(gene name synonym)|uniprotkb:PHB2(gene name)|psi-mi:PHB2(display_short)|uniprotkb:D-prohibitin(gene name synonym)|uniprotkb:B-cell receptor-associated protein BAP37(gene name synonym)|uniprotkb:Repressor of estrogen receptor activity(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001138303.1|ensembl:ENSG00000215021(gene)|ensembl:ENST00000535923(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016477"(cell migration)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033218"(amide binding)|go:"GO:0033600"(negative regulation of mammary gland epithelial cell proliferation)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071944"(cell periphery)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1900208"(regulation of cardiolipin metabolic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904959"(regulation of cytochrome-c oxidase activity)|go:"GO:1990051"(activation of protein kinase C activity)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:Q99623|rcsb pdb:6IQE|reactome:R-HSA-8949664|refseq:NP_001254629.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:h4pib54mBeQgOKCe/hib58LM26w9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O15258 intact:EBI-6179711 intact:EBI-716910|uniprotkb:O95322|ensembl:ENSP00000464222|ensembl:ENSP00000475168 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rer1_human(display_long)|uniprotkb:RER1(gene name)|psi-mi:RER1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_008964.3|refseq:XP_011538844.1|refseq:XP_011538845.1|refseq:XP_006710369.1|ensembl:ENSG00000157916(gene)|ensembl:ENST00000488353(transcript)|ensembl:ENST00000605895(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006621"(protein retention in ER lumen)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0009986"(cell surface)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR004932(Retrieval of early ER protein Rer1)|mint:O15258|refseq:XP_016855622.1|refseq:XP_016855623.1|refseq:XP_016855624.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:rLTZIWGawmaVck0uemR5/E9bFRk9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96R06 intact:EBI-6179711 intact:EBI-413317|uniprotkb:O95213|uniprotkb:Q9BWE8|uniprotkb:Q9NT17|uniprotkb:Q9UFE6|intact:EBI-28972684|ensembl:ENSP00000323300 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:spag5_human(display_long)|uniprotkb:SPAG5(gene name)|psi-mi:SPAG5(display_short)|uniprotkb:Astrin(gene name synonym)|uniprotkb:Mitotic spindle-associated protein p126(gene name synonym)|uniprotkb:Deepest(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_006452.3|ensembl:ENSP00000323300|ensembl:ENSG00000076382(gene)|ensembl:ENST00000321765(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007051"(spindle organization)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035371"(microtubule plus-end)|go:"GO:0036064"(ciliary basal body)|go:"GO:0051294"(establishment of spindle orientation)|go:"GO:0051301"(cell division)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR028728|mint:Q96R06|dip:DIP-30998N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:WOMksaINKpqSxqeGIzbmcSRcgdw9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q8N766 intact:EBI-6179711 intact:EBI-1044442|ensembl:ENSP00000420608|uniprotkb:Q14700|uniprotkb:Q63HL0|uniprotkb:Q63HL3|uniprotkb:Q8NBH8|uniprotkb:A8K6F3|uniprotkb:Q5TG62 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:emc1_human(display_long)|uniprotkb:EMC1(gene name)|psi-mi:EMC1(display_short)|uniprotkb:KIAA0090(gene name synonym)|uniprotkb:PSEC0263(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0045050"(protein insertion into ER membrane by stop-transfer membrane-anchor sequence)|ensembl:ENSG00000127463(gene)|ensembl:ENST00000477853(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0072546"(EMC complex)|interpro:IPR002372(Pyrrolo-quinoline quinone)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR011678(Protein of unknown function DUF1620)|interpro:IPR026895|mint:Q8N766|rcsb pdb:6WW7|rcsb pdb:6Z3W|rcsb pdb:7ADO|rcsb pdb:7ADP|refseq:NP_055862.1|refseq:NP_001258356.1|refseq:NP_001258357.1|refseq:NP_001258358.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:ccxmkDoQwso1qb0UMHePqqRYcnU9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96DZ1 intact:EBI-6179711 intact:EBI-1023677|uniprotkb:O95901|uniprotkb:Q6UWN7|uniprotkb:Q9NUY7|uniprotkb:Q9UQL4|uniprotkb:B2RDB4|ensembl:ENSP00000185150|uniprotkb:B5MC72 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:erlec_human(display_long)|uniprotkb:ER lectin(gene name synonym)|uniprotkb:ERLEC1(gene name)|psi-mi:ERLEC1(display_short)|uniprotkb:XTP3TPB(gene name synonym)|uniprotkb:UNQ1878/PRO4321(orf name)|uniprotkb:C2orf30(gene name synonym)|uniprotkb:XTP3-transactivated gene B protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001120870.1|refseq:NP_056516.2|ensembl:ENSG00000068912(gene)|ensembl:ENST00000185150(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR044865|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0036503"(ERAD pathway)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR012913(Glucosidase II beta subunit-like)|refseq:NP_001120869.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eBOyI1TfCgExBrXLxSwlUZ05NXs9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9P0L0 intact:EBI-6179711 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q99442 intact:EBI-6179711 intact:EBI-949221|ensembl:ENSP00000337688|ensembl:ENSP00000420331|uniprotkb:O00682|uniprotkb:O00729|intact:EBI-2689278|uniprotkb:D3DNQ0 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:sec62_human(display_long)|uniprotkb:SEC62(gene name)|psi-mi:SEC62(display_short)|uniprotkb:TLOC1(gene name synonym)|uniprotkb:Translocation protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000008952(gene)|ensembl:ENST00000337002(transcript)|ensembl:ENST00000480708(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR004728(Translocation protein Sec62)|rcsb pdb:7BRT|refseq:NP_003253.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:u7na6TjTcixVS+ZK2ygkFA1QDKY9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q15005 intact:EBI-6179711 intact:EBI-1043352|uniprotkb:Q15507|uniprotkb:Q3KQT0|uniprotkb:Q641R4|uniprotkb:Q6FG65|uniprotkb:Q6IRX0|ensembl:ENSP00000263672|uniprotkb:Q6P1P4|uniprotkb:Q96HU9 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:spcs2_human(display_long)|uniprotkb:Microsomal signal peptidase 25 kDa subunit(gene name synonym)|uniprotkb:SPCS2(gene name)|psi-mi:SPCS2(display_short)|uniprotkb:KIAA0102(gene name synonym)|uniprotkb:SPC25(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSG00000118363(gene)|ensembl:ENST00000263672(transcript)|go:"GO:0005787"(signal peptidase complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006465"(signal peptide processing)|go:"GO:0008233"(peptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR009582(Microsomal signal peptidase 25 kDa subunit)|mint:Q15005|reactome:R-HSA-1799339|reactome:R-HSA-381771|reactome:R-HSA-400511|reactome:R-HSA-422085|refseq:NP_055567.2|dip:DIP-47276N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:3POhDKvg+aoZiz2XRTC+m77XTAw9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P49257 intact:EBI-6179711 intact:EBI-1057738|uniprotkb:Q9UQG4|uniprotkb:Q9UQG5|uniprotkb:Q9UQG6|uniprotkb:Q9UQG7|uniprotkb:Q9UQG8|uniprotkb:Q9UQG9|uniprotkb:Q9UQH0|uniprotkb:Q9UQH1|uniprotkb:Q9UQH2|uniprotkb:Q12895|uniprotkb:Q8N5I7|uniprotkb:Q9UQG1|uniprotkb:Q9UQG2|uniprotkb:Q9UQG3|ensembl:ENSP00000251047 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:lman1_human(display_long)|uniprotkb:LMAN1(gene name)|psi-mi:LMAN1(display_short)|uniprotkb:ERGIC53(gene name synonym)|uniprotkb:F5F8D(gene name synonym)|uniprotkb:ER-Golgi intermediate compartment 53 kDa protein(gene name synonym)|uniprotkb:Lectin mannose-binding 1(gene name synonym)|uniprotkb:Gp58(gene name synonym)|uniprotkb:Intracellular mannose-specific lectin MR60(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005561.1|ensembl:ENSG00000074695(gene)|ensembl:ENST00000251047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005537"(mannose binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007596"(blood coagulation)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030017"(sarcomere)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|interpro:IPR005052(Legume-like lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR033085|mint:P49257|rcsb pdb:3A4U|rcsb pdb:3LCP|rcsb pdb:3WHT|rcsb pdb:3WHU|rcsb pdb:3WNX|rcsb pdb:4GKX|rcsb pdb:4GKY|rcsb pdb:4YGB|rcsb pdb:4YGC|rcsb pdb:4YGD|rcsb pdb:4YGE|reactome:R-HSA-204005|reactome:R-HSA-5694530|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|go:"GO:0016021"(integral component of membrane)|reactome:R-HSA-948021|reactome:R-HSA-9013423|dip:DIP-42188N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CWmvVATvXXjzMqSD0KjTBvmKKuI9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O15260 intact:EBI-6179711 intact:EBI-1044848|uniprotkb:O60923|uniprotkb:Q9UNZ0|uniprotkb:Q9UNZ1|uniprotkb:Q5T8U6|ensembl:ENSP00000361057|ensembl:ENSP00000486049|uniprotkb:B7Z6A4 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:surf4_human(display_long)|uniprotkb:SURF4(gene name)|psi-mi:SURF4(display_short)|uniprotkb:SURF-4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_149351.1|ensembl:ENSG00000148248(gene)|ensembl:ENSG00000280951(gene)|ensembl:ENST00000629578(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010638"(positive regulation of organelle organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030133"(transport vesicle)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035577"(azurophil granule membrane)|interpro:IPR002995(Surfeit locus 4)|mint:O15260|reactome:R-HSA-6798695|reactome:R-HSA-6811434|ensembl:ENST00000371989(transcript)|refseq:NP_001267718.1|refseq:NP_001267721.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:VEkKSEfWLmSZx209HLRfoMMTzsg9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9NVV0 intact:EBI-6179711 intact:EBI-1055114|uniprotkb:Q5JR63|uniprotkb:Q5SVN5|uniprotkb:Q5SVN6|uniprotkb:Q5VTE2|uniprotkb:Q6IA97|ensembl:ENSP00000363824 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tm38b_human(display_long)|uniprotkb:Transmembrane protein 38B(gene name synonym)|uniprotkb:C9orf87(gene name synonym)|uniprotkb:TMEM38B(gene name)|psi-mi:TMEM38B(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_060582.1|ensembl:ENSG00000095209(gene)|ensembl:ENST00000374692(transcript)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0060348"(bone development)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR007866(Protein of unknown function DUF714) psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:feIrxCWNpLCnAMaRwBsiKiz2y9w9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P35232 intact:EBI-6179711 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q96AJ9 intact:EBI-6179711 intact:EBI-3923262|uniprotkb:B4E137|uniprotkb:A2A307|ensembl:ENSP00000376792|uniprotkb:Q5W0D7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:vti1a_human(display_long)|uniprotkb:VTI1A(gene name)|psi-mi:VTI1A(display_short)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_660207.2|ensembl:ENSG00000151532(gene)|ensembl:ENST00000393077(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|mint:Q96AJ9|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001305132.1|refseq:NP_001305134.1|refseq:XP_005269601.1|dip:DIP-44223N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:MZOfyoq6Oe9cFxPKa3ZxWTuPTrI9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9P035 intact:EBI-6179711 intact:EBI-359013|intact:EBI-1049123|uniprotkb:A0PJA1|uniprotkb:Q280Z3|uniprotkb:Q6PD63|uniprotkb:Q8IUI5|uniprotkb:Q8NC86|uniprotkb:Q8NCB1|uniprotkb:Q96T12|uniprotkb:Q9NQA7|uniprotkb:B4DRF4|intact:EBI-28973764|ensembl:ENSP00000261875 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:hacd3_human(display_long)|uniprotkb:Butyrate-induced protein 1(gene name synonym)|uniprotkb:PTPLAD1(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase-like A domain-containing protein 1(gene name synonym)|uniprotkb:HACD3(gene name)|psi-mi:HACD3(display_short)|uniprotkb:3-hydroxyacyl-CoA dehydratase 3(gene name synonym)|uniprotkb:BIND1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) ensembl:ENSP00000261875|ensembl:ENST00000442729|ensembl:ENSP00000392491|refseq:NP_057479.2|ensembl:ENSG00000074696(gene)|ensembl:ENST00000261875(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0018812"(3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030497"(fatty acid elongation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042761"(very long-chain fatty acid biosynthetic process)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0102158"(very-long-chain 3-hydroxyacyl-CoA dehydratase activity)|go:"GO:0102343"(3-hydroxy-arachidoyl-CoA dehydratase activity)|go:"GO:0102344"(3-hydroxy-behenoyl-CoA dehydratase activity)|go:"GO:0102345"(3-hydroxy-lignoceroyl-CoA dehydratase activity)|interpro:IPR007052(CS domain)|interpro:IPR007482(Protein-tyrosine phosphatase-like, PTPLA)|interpro:IPR008978(HSP20-like chaperone)|mint:Q9P035|reactome:R-HSA-75876 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:U31K6H8I2f5j7FRhfHiY0cG4smA9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P51572 intact:EBI-6179711 intact:EBI-77683|ensembl:ENSP00000343458|ensembl:ENSP00000494052|ensembl:ENSP00000499882|uniprotkb:Q13836|uniprotkb:Q96CF0|uniprotkb:D3DWV5|uniprotkb:B3KQ79 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:bap31_human(display_long)|uniprotkb:BCAP31(gene name)|psi-mi:BCAP31(display_short)|uniprotkb:BAP31(gene name synonym)|uniprotkb:p28(gene name synonym)|uniprotkb:6C6-AG tumor-associated antigen(gene name synonym)|uniprotkb:DXS1357E(gene name synonym)|uniprotkb:Protein CDM(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001132913.1|refseq:NP_005736.3|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904154"(positive regulation of retrograde protein transport, ER to cytosol)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR008417(B-cell receptor-associated 31-like)|interpro:IPR040463|interpro:IPR041672|mint:P51572|rcsb pdb:4JZL|rcsb pdb:4JZP|reactome:R-HSA-111465|reactome:R-HSA-75153|reactome:R-HSA-8980692|reactome:R-HSA-983170|ensembl:ENSG00000185825(gene)|ensembl:ENST00000345046(transcript)|ensembl:ENST00000647529(transcript)|ensembl:ENST00000672675(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0032471"(negative regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044877"(protein-containing complex binding)|refseq:NP_001243376.1|refseq:NP_001132929.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:m0aN00PLZJDWA/K1vEbla1W9+S89606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O60220 intact:EBI-6179711 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q92896 intact:EBI-6179711 intact:EBI-359610|uniprotkb:Q6P9D1|uniprotkb:Q13221|uniprotkb:D3DUJ7|uniprotkb:B7Z8Y4|ensembl:ENSP00000405984 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:gslg1_human(display_long)|uniprotkb:GLG1(gene name)|psi-mi:GLG1(display_short)|uniprotkb:CFR1(gene name synonym)|uniprotkb:ESL1(gene name synonym)|uniprotkb:MG160(gene name synonym)|uniprotkb:Golgi sialoglycoprotein MG-160(gene name synonym)|uniprotkb:E-selectin ligand 1(gene name synonym)|uniprotkb:Cysteine-rich fibroblast growth factor receptor(gene name synonym)|uniprotkb:CFR-1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001139138.1|refseq:NP_001139139.1|refseq:NP_036333.2|ensembl:ENSG00000090863(gene)|ensembl:ENST00000422840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001893(Cysteine rich repeat)|interpro:IPR017873|interpro:IPR039728|reactome:R-HSA-202733|dip:DIP-27582N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:FTlNQD3o/wkPVjXkbB/G73BoBhw9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y3P9 intact:EBI-6179711 intact:EBI-1057545|uniprotkb:Q05CW2|uniprotkb:Q6ZMY1|uniprotkb:Q9HA28|uniprotkb:Q9P0E2|uniprotkb:Q9UG67|intact:EBI-2948690|uniprotkb:B9A6L2|ensembl:ENSP00000362751 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rbgp1_human(display_long)|uniprotkb:RABGAP1(gene name)|psi-mi:RABGAP1(display_short)|uniprotkb:HSPC094(orf name)|uniprotkb:Rab6 GTPase-activating protein GAPCenA(gene name synonym)|uniprotkb:GAP and centrosome-associated protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:XP_011516742.1|refseq:XP_011516743.1|refseq:NP_036329.3|ensembl:ENSG00000011454(gene)|ensembl:ENST00000373647(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0015631"(tubulin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022164|interpro:IPR033185|interpro:IPR035969|mint:Q9Y3P9|rcsb pdb:4NC6|reactome:R-HSA-8854214|refseq:XP_016870056.1|refseq:XP_016870057.1|refseq:XP_016870058.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:yGnx7q5tyqYfpbeVDwZ8IKI1o+k9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y5J9 intact:EBI-6179711 intact:EBI-1049085|uniprotkb:Q3KQS9|uniprotkb:Q9UN04|uniprotkb:B0YJA5|ensembl:ENSP00000422122 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tim8b_human(display_long)|uniprotkb:Deafness dystonia protein 2(gene name synonym)|uniprotkb:DDP-like protein(gene name synonym)|uniprotkb:TIM8B(gene name synonym)|uniprotkb:TIMM8B(gene name)|psi-mi:TIMM8B(display_short)|uniprotkb:DDP2(gene name synonym)|uniprotkb:DDPL(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_036591.2|ensembl:ENSG00000150779(gene)|ensembl:ENST00000504148(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5J9|reactome:R-HSA-1268020 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:7DK/1BIkwyl9KMIgEFWqRhZn2ZE9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9Y5L4 intact:EBI-6179711 intact:EBI-1057344|uniprotkb:P62206|uniprotkb:Q9UHL8|uniprotkb:Q9WTL1|ensembl:ENSP00000215570 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:tim13_human(display_long)|uniprotkb:TIMM13(gene name)|psi-mi:TIMM13(display_short)|uniprotkb:TIM13B(gene name synonym)|uniprotkb:TIMM13A(gene name synonym)|uniprotkb:TIMM13B(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_036590.1|ensembl:ENSG00000099800(gene)|ensembl:ENST00000215570(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:Q9Y5L4|reactome:R-HSA-1268020 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:kFNYBvKwUM0JECXq9FjvYv55JAM9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P08134 intact:EBI-6179711 intact:EBI-747589|uniprotkb:Q6ICN3|uniprotkb:B3KSW1|ensembl:ENSP00000285735|ensembl:ENSP00000345236|ensembl:ENSP00000358646|ensembl:ENSP00000358647|ensembl:ENSP00000358651|ensembl:ENSP00000358652|ensembl:ENSP00000358656 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:rhoc_human(display_long)|uniprotkb:Rho cDNA clone 9(gene name synonym)|uniprotkb:RHOC(gene name)|psi-mi:RHOC(display_short)|uniprotkb:ARH9(gene name synonym)|uniprotkb:ARHC(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001036143.1|refseq:NP_001036144.1|refseq:NP_786886.1|ensembl:ENSG00000155366(gene)|ensembl:ENST00000285735(transcript)|ensembl:ENST00000339083(transcript)|ensembl:ENST00000369632(transcript)|ensembl:ENST00000369633(transcript)|ensembl:ENST00000369637(transcript)|ensembl:ENST00000369638(transcript)|ensembl:ENST00000369642(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032420"(stereocilium)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902766"(skeletal muscle satellite cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P08134|rcsb pdb:1Z2C|rcsb pdb:2GCN|rcsb pdb:2GCO|rcsb pdb:2GCP|reactome:R-HSA-416482|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-9013106 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:CPt/q5soDZILGfkngD41Y1U4eys9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P48426 intact:EBI-6179711 intact:EBI-3924422|uniprotkb:Q5VUX3|uniprotkb:D3DRV1|uniprotkb:B0YJ66|uniprotkb:P53807|ensembl:ENSP00000365757|uniprotkb:B4DGX2 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pi42a_human(display_long)|uniprotkb:PIP4K2A(gene name)|psi-mi:PIP4K2A(display_short)|uniprotkb:PIP5K2(gene name synonym)|uniprotkb:PIP5K2A(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:PIP5KIII(gene name synonym)|uniprotkb:"PtdIns(4)P-5-kinase B isoform"(gene name synonym)|uniprotkb:"PtdIns(4)P-5-kinase C isoform"(gene name synonym)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:PI5P4KA(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_005019.2|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|ensembl:ENST00000376573(transcript)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:P48426|rcsb pdb:2YBX|rcsb pdb:6OSP|rcsb pdb:6UX9|rcsb pdb:6YM3|rcsb pdb:6YM4|rcsb pdb:6YM5|rcsb pdb:7N6Z|rcsb pdb:7N7J|rcsb pdb:7N7K|rcsb pdb:7N7L|rcsb pdb:7N7M|rcsb pdb:7N7N|rcsb pdb:7N7O|reactome:R-HSA-1660499|reactome:R-HSA-6811555|reactome:R-HSA-6811558|reactome:R-HSA-8847453|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|ensembl:ENSG00000150867(gene)|refseq:NP_001316991.1|refseq:XP_016871819.1|refseq:XP_016871820.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:Fmsp/H2ucCjs7wyiCgEqe9Y5UT49606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9NYU2 intact:EBI-6179711 intact:EBI-1056389|uniprotkb:Q53SL3|uniprotkb:Q8IW30|uniprotkb:Q9H8I4|uniprotkb:Q53QP2|ensembl:ENSP00000259253 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:uggg1_human(display_long)|uniprotkb:UGGT1(gene name)|psi-mi:UGGT1(display_short)|uniprotkb:GT(gene name synonym)|uniprotkb:UGGT(gene name synonym)|uniprotkb:UGT1(gene name synonym)|uniprotkb:UGTR(gene name synonym)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase"(gene name synonym)|uniprotkb:UGCGL1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_064505.1|ensembl:ENSG00000136731(gene)|ensembl:ENST00000259253(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051084"('de novo' posttranslational protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|mint:Q9NYU2|reactome:R-HSA-901032 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.93 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:WgjCB9PJiHtQXloeFEerSmIoQU89606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O00264 intact:EBI-6179711 intact:EBI-1045534|uniprotkb:Q9UGJ9|ensembl:ENSP00000217971|uniprotkb:B7Z1L3 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:pgrc1_human(display_long)|uniprotkb:Dap1(gene name synonym)|uniprotkb:IZA(gene name synonym)|uniprotkb:PGRMC1(gene name)|psi-mi:PGRMC1(display_short)|uniprotkb:HPR6.6(gene name synonym)|uniprotkb:PGRMC(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001269550.1|ensembl:ENST00000217971(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR036400|mint:O00264|rcsb pdb:4X8Y|reactome:R-HSA-6798695|ensembl:ENSG00000101856(gene)|refseq:NP_006658.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:fjKpwgj9042mPhLsvS/wu1wBEi89606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:Q9UBV2 intact:EBI-6179711 intact:EBI-358766|uniprotkb:Q6UWT6|uniprotkb:Q9P1T9|uniprotkb:Q9UHK7|ensembl:ENSP00000337053 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:se1l1_human(display_long)|uniprotkb:SEL1L(gene name)|psi-mi:SEL1L(display_short)|uniprotkb:TSA305(gene name synonym)|uniprotkb:UNQ128/PRO1063(orf name)|uniprotkb:Suppressor of lin-12-like protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001231913.1|refseq:NP_005056.3|ensembl:ENSG00000071537(gene)|ensembl:ENST00000336735(transcript)|go:"GO:0000836"(Hrd1p ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009306"(protein secretion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0050821"(protein stabilization)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR006597(Sel1-like)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|mint:Q9UBV2|reactome:R-HSA-1912420|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032|dip:DIP-46259N psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:eufE+8nfcHK8CDl+AQ5G+3NtL+09606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:O75955 intact:EBI-6179711 intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04578-PRO_0000038428 uniprotkb:P14314 intact:EBI-6179711 intact:EBI-716953|uniprotkb:Q96BU9|uniprotkb:Q96D06|uniprotkb:Q9P0W9|uniprotkb:A8K318|ensembl:ENSP00000465461 psi-mi:p04578-pro_0000038428(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym) psi-mi:glu2b_human(display_long)|uniprotkb:Glucosidase II subunit beta(gene name synonym)|uniprotkb:Protein kinase C substrate 60.1 kDa protein heavy chain(gene name synonym)|uniprotkb:80K-H protein(gene name synonym)|uniprotkb:PRKCSH(gene name)|psi-mi:PRKCSH(display_short)|uniprotkb:G19P1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177603|imex:IM-17346-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163496(chain-parent)|uniprotkb:P04578(chain-parent) refseq:NP_001001329.1|refseq:NP_002734.2|refseq:XP_011526433.1|refseq:XP_011526434.1|refseq:NP_001276031.1|ensembl:ENSG00000130175(gene)|ensembl:ENST00000589838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006491"(N-glycan processing)|go:"GO:0017177"(glucosidase II complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051219"(phosphoprotein binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028146|interpro:IPR036055|interpro:IPR036607|interpro:IPR039794|interpro:IPR044865|mint:P14314|reactome:R-HSA-381426|reactome:R-HSA-532668|reactome:R-HSA-879415|reactome:R-HSA-8957275|reactome:R-HSA-901042|reactome:R-HSA-9683686|reactome:R-HSA-9694548|refseq:XP_016882466.1 psi-mi:"MI:0096"(pull down) chain-seq-start:512|chain-seq-end:856|comment:Extra met in N-terminal author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Um5HVQP6DRWZ1Q9WbygUiIxmwpc11706 rogid:hs2AZthZKK6KVW8Blm1RuZVh1QM9606 intact-crc:3F2429DE8D32CC58|rigid:d6gUgUDfh7q5zL1EiHnvwPmlzTY false tandem tag:c-c("MI:0677")|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9HD40 uniprotkb:P04591-PRO_0000038593 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 intact:EBI-6179719 psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177723|imex:IM-17346-57 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) author-confidence:0.83 chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:F50FC9967E8F11E9|rigid:MO3xx+OC2Xt0JXaITth1tAQQJzQ false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:O14734 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177741|imex:IM-17346-58 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity) psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606 intact-crc:F59375F4716F8CF0|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:P30419 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-5280164|uniprotkb:A8K7C1|uniprotkb:Q9UE09|ensembl:ENSP00000258960|ensembl:ENSP00000468424|ensembl:ENSP00000504192 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:nmt1_human(display_long)|uniprotkb:NMT1(gene name)|psi-mi:NMT1(display_short)|uniprotkb:NMT(gene name synonym)|uniprotkb:"Myristoyl-CoA:protein N-myristoyltransferase 1"(gene name synonym)|uniprotkb:Peptide N-myristoyltransferase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177741|imex:IM-17346-58 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_066565.1|ensembl:ENSG00000136448(gene)|ensembl:ENST00000258960(transcript)|ensembl:ENST00000592782(transcript)|ensembl:ENST00000676828(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004379"(glycylpeptide N-tetradecanoyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0018008"(N-terminal peptidyl-glycine N-myristoylation)|go:"GO:0019107"(myristoyltransferase activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0042180"(cellular ketone metabolic process)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR000903("Myristoyl-CoA:protein N-myristoyltransferase")|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR022676|interpro:IPR022677|interpro:IPR022678|rcsb pdb:1RXT|rcsb pdb:3IU1|rcsb pdb:3IU2|rcsb pdb:3IWE|rcsb pdb:3JTK|rcsb pdb:4C2Y|rcsb pdb:4C2Z|rcsb pdb:5MU6|rcsb pdb:5NPQ|rcsb pdb:5O6H|rcsb pdb:5O6J|rcsb pdb:5O9S|rcsb pdb:5O9T|rcsb pdb:5O9U|rcsb pdb:5O9V|rcsb pdb:5UUT|rcsb pdb:6EHJ|rcsb pdb:6F56|rcsb pdb:6FZ2|rcsb pdb:6FZ3|rcsb pdb:6FZ5|rcsb pdb:6PAV|rcsb pdb:6QRM|rcsb pdb:6SJZ|rcsb pdb:6SK2|rcsb pdb:6SK3|rcsb pdb:6SK8|rcsb pdb:6SKJ|reactome:R-HSA-162599|reactome:R-HSA-2514859|reactome:R-HSA-75108|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:eVkADRJp/cg4xIAw0ymeUZ+Vwyk9606 intact-crc:F59375F4716F8CF0|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:Q96A65 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-355383|intact:EBI-1058596|uniprotkb:Q9C0G4|uniprotkb:Q9H9K0|uniprotkb:Q9P102|uniprotkb:Q541U8|uniprotkb:E9PED2|ensembl:ENSP00000253861 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:exoc4_human(display_long)|uniprotkb:EXOC4(gene name)|psi-mi:EXOC4(display_short)|uniprotkb:KIAA1699(gene name synonym)|uniprotkb:SEC8(gene name synonym)|uniprotkb:SEC8L1(gene name synonym)|uniprotkb:Exocyst complex component Sec8(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177741|imex:IM-17346-58 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_068579.3|dip:DIP-32976N|ensembl:ENSG00000131558(gene)|ensembl:ENST00000253861(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032584"(growth cone membrane)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0045202"(synapse)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0090543"(Flemming body)|interpro:IPR007191(Sec8 exocyst complex component specific domain)|interpro:IPR039682|mint:Q96A65|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916|go:"GO:0090522"(vesicle tethering involved in exocytosis) psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:cISO7v2OxFaDg0qe9XNV0Qoyby89606 intact-crc:F59375F4716F8CF0|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04601 uniprotkb:Q969X5 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-781527|uniprotkb:Q9H0L0|uniprotkb:Q9H2J2|uniprotkb:Q9ULN9|ensembl:ENSP00000377374 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:ergi1_human(display_long)|uniprotkb:ER-Golgi intermediate compartment 32 kDa protein(gene name synonym)|uniprotkb:ERGIC1(gene name)|psi-mi:ERGIC1(display_short)|uniprotkb:KIAA1181(gene name synonym)|uniprotkb:HT034(orf name)|uniprotkb:ERGIC32(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177741|imex:IM-17346-58 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:XP_006714955.1|refseq:NP_001026881.1|ensembl:ENSG00000113719(gene)|ensembl:ENST00000393784(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR012936(Protein of unknown function DUF1692)|interpro:IPR039542 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:UbuPGmvwVwrwg/LT5oAn9pLs5Hw9606 intact-crc:F59375F4716F8CF0|rigid:tAmEbFkanMfrEhpJey9N2a3jcQY false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9BRX2 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1043580|uniprotkb:Q9GZS6|uniprotkb:Q9Y306|ensembl:ENSP00000274311 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pelo_human(display_long)|uniprotkb:PELO(gene name)|psi-mi:PELO(display_short)|uniprotkb:CGI-17(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000152684(gene)|ensembl:ENST00000274311(transcript)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0007049"(cell cycle)|go:"GO:0007492"(endoderm development)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032790"(ribosome disassembly)|go:"GO:0046872"(metal ion binding)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0070651"(nonfunctional rRNA decay)|go:"GO:0070966"(nuclear-transcribed mRNA catabolic process, no-go decay)|go:"GO:0071025"(RNA surveillance)|interpro:IPR004405(Probable translation factor pelota)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR029064|interpro:IPR038069|interpro:IPR042226|mint:Q9BRX2|rcsb pdb:1X52|rcsb pdb:5EO3|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|refseq:NP_057030.3 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:EZIi8JN2tu0u4oH06fOus3LKjoo9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9H4L5 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9P2R7 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q15084 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-1043087|uniprotkb:Q6ZSH5|ensembl:ENSP00000272227|uniprotkb:B3KY95|uniprotkb:B5MCQ5|uniprotkb:B7Z4M8|uniprotkb:F8WA83|uniprotkb:B7Z254|uniprotkb:Q99778|uniprotkb:Q53RC7 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:pdia6_human(display_long)|uniprotkb:PDIA6(gene name)|psi-mi:PDIA6(display_short)|uniprotkb:TXNDC7(gene name synonym)|uniprotkb:Protein disulfide isomerase P5(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 7(gene name synonym)|uniprotkb:ERP5(gene name synonym)|uniprotkb:P5(gene name synonym)|uniprotkb:Endoplasmic reticulum protein 5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001269633.1|refseq:NP_001269634.1|refseq:NP_001269635.1|refseq:NP_001269636.1|interpro:IPR036249|interpro:IPR044569|mint:Q15084|rcsb pdb:1X5D|rcsb pdb:3VWW|rcsb pdb:3W8J|rcsb pdb:4EF0|rcsb pdb:4GWR|reactome:R-HSA-381038|reactome:R-HSA-381426|reactome:R-HSA-8957275|interpro:IPR017937|ensembl:ENSG00000143870(gene)|ensembl:ENST00000272227(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0042470"(melanosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005733.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:411bo7TdfeCtMvUqyBb7bofi5To9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O00303 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q2T9J0 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-2510623|ensembl:ENSP00000287078|uniprotkb:Q8N6H2|uniprotkb:Q5SQU1|uniprotkb:Q96AR5|uniprotkb:Q5SQT4 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:tysd1_human(display_long)|uniprotkb:TYSND1(gene name)|psi-mi:TYSND1(display_short)|uniprotkb:Trypsin domain-containing protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000156521(gene)|ensembl:ENST00000287078(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0042802"(identical protein binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017345(Peptidase S1B, Tysnd1)|interpro:IPR039245|reactome:R-HSA-9033241|reactome:R-HSA-9033500|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001035363.1|refseq:NP_775826.2 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:nfBCzADhPAnpbY6GasKVCOaZjjs9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P60228 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15372 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y266 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P07858 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q8N163 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q99613 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:O15371 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P33991 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q14566 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:P33993 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y262 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P03366 uniprotkb:Q9Y265 intact:EBI-6164084|uniprotkb:P03368 intact:EBI-353675|uniprotkb:P82276|uniprotkb:Q1KMR0|uniprotkb:Q53HK5|uniprotkb:Q53HL7|uniprotkb:Q53Y27|uniprotkb:Q9BSX9|uniprotkb:B2R5S0|ensembl:ENSP00000318297|ensembl:ENSP00000494621 psi-mi:pol_hv1b1(display_long)|uniprotkb:gag-pol(gene name)|psi-mi:gag-pol(display_short)|uniprotkb:Pr160Gag-Pol(gene name synonym) psi-mi:ruvb1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short)|uniprotkb:NMP238(gene name synonym)|uniprotkb:TIP49(gene name synonym)|uniprotkb:TIP49A(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:Nuclear matrix protein 238(gene name synonym)|uniprotkb:54 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80H(gene name synonym)|uniprotkb:TIP60-associated protein 54-alpha(gene name synonym)|uniprotkb:INO80 complex subunit H(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11678(hv1b1)|taxid:11678("Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177782|imex:IM-17346-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:3ZPS|rcsb pdb:3ZPT|rcsb pdb:3ZPU|rcsb pdb:4MFB|rcsb pdb:6WAZ|rcsb pdb:6WB0|rcsb pdb:6WB1|rcsb pdb:6WB2|rcsb pdb:6X47|rcsb pdb:6X49|rcsb pdb:6X4A|rcsb pdb:6X4B|rcsb pdb:6X4C|rcsb pdb:6X4D|rcsb pdb:6X4E|rcsb pdb:6X4F|rcsb pdb:7KJV|rcsb pdb:7KJW|rcsb pdb:7KJX|rcsb pdb:7KWU|rcsb pdb:4LSL|rcsb pdb:4LSN|rcsb pdb:4O44|rcsb pdb:4ZIP|rcsb pdb:4ZLS|rcsb pdb:5C24|rcsb pdb:5C25|rcsb pdb:5C42|rcsb pdb:4O4G|rcsb pdb:4U8W|rcsb pdb:6PRF|rcsb pdb:4COE|rcsb pdb:4CP7|rcsb pdb:4WE1|rcsb pdb:5TER|rcsb pdb:6ELI|interpro:IPR036397|interpro:IPR036862|interpro:IPR036875|rcsb pdb:5TUQ|rcsb pdb:5ULT|rcsb pdb:5UOV|rcsb pdb:5UPZ|rcsb pdb:5UV5|rcsb pdb:5V5L|rcsb pdb:5V5M|rcsb pdb:5VQQ|rcsb pdb:5VQR|rcsb pdb:5VQS|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004523"(RNA-DNA hybrid ribonuclease activity)|go:"GO:0004533"(exoribonuclease H activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008289"(lipid binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016020"(membrane)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039651"(induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0039657"(suppression by virus of host gene expression)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044826"(viral genome integration into host DNA)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body)|go:"GO:0075732"(viral penetration into host nucleus)|go:"GO:0075713"(establishment of integrated proviral latency)|rcsb pdb:5W5W|rcsb pdb:4CPQ|rcsb pdb:4CPR|rcsb pdb:4CPS|rcsb pdb:4CPT|rcsb pdb:4CPU|rcsb pdb:4CPW|rcsb pdb:4CPX|rcsb pdb:5FDL|rcsb pdb:5HBM|rcsb pdb:5HLF|rcsb pdb:5VQT|rcsb pdb:5VQU|rcsb pdb:5VQV|rcsb pdb:5VQW|rcsb pdb:5VQX|rcsb pdb:5VQY|rcsb pdb:5VQZ|rcsb pdb:5D3G|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|rcsb pdb:7AHX|rcsb pdb:7AID|rcsb pdb:7AIF|rcsb pdb:7AIG|rcsb pdb:7AII|rcsb pdb:7AIJ|rcsb pdb:7KRC|rcsb pdb:7KRD|rcsb pdb:7KRE|rcsb pdb:7KRF|rcsb pdb:4OJR|rcsb pdb:4PQU|rcsb pdb:4PUO|rcsb pdb:4PWD|rcsb pdb:4Q0B|rcsb pdb:4QAG|rcsb pdb:4R5P|rcsb pdb:5AH7|rcsb pdb:5T6Z|rcsb pdb:5T70|rcsb pdb:5TW3|rcsb pdb:3KLG|rcsb pdb:3KLH|rcsb pdb:3KLI|rcsb pdb:3NDT|rcsb pdb:3NU3|rcsb pdb:3NU4|rcsb pdb:3NU5|rcsb pdb:3NU6|rcsb pdb:3NU9|rcsb pdb:3NUJ|rcsb pdb:3NUO|rcsb pdb:3OK9|rcsb pdb:3PSU|rcsb pdb:3QAA|rcsb pdb:3QLH|rcsb pdb:3QO9|rcsb pdb:3TKG|rcsb pdb:3TKW|rcsb pdb:3TL9|rcsb pdb:3TLH|rcsb pdb:3V4I|rcsb pdb:3V6D|rcsb pdb:3V81|rcsb pdb:6D0D|rcsb pdb:6D0E|rcsb pdb:2JZW|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR002156(Ribonuclease H)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010659(Reverse transcriptase connection)|interpro:IPR010661(Reverse transcriptase thumb)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR018061|interpro:IPR021109|rcsb pdb:1A9M|rcsb pdb:1AJV|rcsb pdb:1AJX|rcsb pdb:1AXA|rcsb pdb:1BQM|rcsb pdb:1BQN|rcsb pdb:1D4H|rcsb pdb:1D4I|rcsb pdb:1D4J|rcsb pdb:1DLO|rcsb pdb:1DW6|rcsb pdb:1EBK|rcsb pdb:1EBW|rcsb pdb:1EBY|rcsb pdb:1EBZ|rcsb pdb:1EC0|rcsb pdb:1EC1|rcsb pdb:1EC2|rcsb pdb:1EC3|rcsb pdb:1EET|rcsb pdb:1G35|rcsb pdb:1GNM|rcsb pdb:1GNN|rcsb pdb:1GNO|rcsb pdb:1HAR|rcsb pdb:1HBV|rcsb pdb:1HEF|rcsb pdb:1HEG|rcsb pdb:1HIH|rcsb pdb:1HMV|rcsb pdb:1HNI|rcsb pdb:1HNV|rcsb pdb:1HOS|rcsb pdb:1HPS|rcsb pdb:1HPZ|rcsb pdb:1HQE|rcsb pdb:1HQU|rcsb pdb:1HRH|rcsb pdb:1HTE|rcsb pdb:1HTF|rcsb pdb:1HTG|rcsb pdb:1HVI|rcsb pdb:1HVK|rcsb pdb:1HVP|rcsb pdb:1HVU|rcsb pdb:1HYS|rcsb pdb:1IKV|rcsb pdb:1IKW|rcsb pdb:1IKX|rcsb pdb:1IKY|rcsb pdb:1J5O|rcsb pdb:1KJH|rcsb pdb:1MER|rcsb pdb:1MES|rcsb pdb:1MET|rcsb pdb:1MEU|rcsb pdb:1N5Y|rcsb pdb:1N6Q|rcsb pdb:1NPA|rcsb pdb:1NPV|rcsb pdb:1NPW|rcsb pdb:1QE1|rcsb pdb:1QMC|rcsb pdb:1R0A|rcsb pdb:1RDH|rcsb pdb:1RTD|rcsb pdb:1RVL|rcsb pdb:1RVM|rcsb pdb:1RVN|rcsb pdb:1RVO|rcsb pdb:1RVP|rcsb pdb:1RVQ|rcsb pdb:1RVR|rcsb pdb:1S6P|rcsb pdb:1S6Q|rcsb pdb:1S9E|rcsb pdb:1S9G|rcsb pdb:1SBG|rcsb pdb:1SUQ|rcsb pdb:1SV5|rcsb pdb:1T03|rcsb pdb:1T05|rcsb pdb:1T7K|rcsb pdb:1TV6|rcsb pdb:1TVR|rcsb pdb:1UWB|rcsb pdb:1W5V|rcsb pdb:1W5W|rcsb pdb:1W5X|rcsb pdb:1W5Y|rcsb pdb:1YT9|rcsb pdb:1ZP8|rcsb pdb:1ZPA|rcsb pdb:1ZSF|rcsb pdb:1ZSR|rcsb pdb:2AQU|rcsb pdb:2B5J|rcsb pdb:2B6A|rcsb pdb:2BAN|rcsb pdb:2BBB|rcsb pdb:2BE2|rcsb pdb:2EXF|rcsb pdb:2G69|rcsb pdb:2HB3|rcsb pdb:2HMI|rcsb pdb:2HNZ|rcsb pdb:2HS1|rcsb pdb:2HS2|rcsb pdb:2I4D|rcsb pdb:2I4U|rcsb pdb:2I4V|rcsb pdb:2I4W|rcsb pdb:2I4X|rcsb pdb:2I5J|rcsb pdb:2IAJ|rcsb pdb:2IC3|rcsb pdb:2IDW|rcsb pdb:2IEO|rcsb pdb:2L45|rcsb pdb:2L46|rcsb pdb:2L4L|rcsb pdb:2UXZ|rcsb pdb:2UY0|rcsb pdb:2VG5|rcsb pdb:2VG6|rcsb pdb:2VG7|rcsb pdb:2X4U|rcsb pdb:2YKM|rcsb pdb:2YKN|rcsb pdb:2ZD1|rcsb pdb:2ZE2|rcsb pdb:3AVI|rcsb pdb:3BGR|rcsb pdb:3DLK|rcsb pdb:3GGA|rcsb pdb:3GGV|rcsb pdb:3GGX|rcsb pdb:3HVT|rcsb pdb:3IG1|rcsb pdb:3IRX|rcsb pdb:3IS9|rcsb pdb:3ISN|rcsb pdb:3ITH|rcsb pdb:3JSM|rcsb pdb:3JYT|rcsb pdb:3K2P|rcsb pdb:3K4V|rcsb pdb:3KLE|rcsb pdb:3KLF|rcsb pdb:4G1Q|rcsb pdb:4ICL|rcsb pdb:4ID5|rcsb pdb:4IDK|rcsb pdb:4IFV|rcsb pdb:4IFY|rcsb pdb:4IG0|rcsb pdb:4IG3|rcsb pdb:6O9E|rcsb pdb:4DG1|rcsb pdb:4KFB|rcsb pdb:5HP1|rcsb pdb:5HRO|rcsb pdb:5I3U|rcsb pdb:5I42|rcsb pdb:5J1E|rcsb pdb:4H4M|rcsb pdb:4H4O|rcsb pdb:4I2P|rcsb pdb:4I2Q|rcsb pdb:4G8G|rcsb pdb:4G8I|rcsb pdb:4G9D|rcsb pdb:4G9F|rcsb pdb:4RW4|rcsb pdb:4RW6|rcsb pdb:4RW7|rcsb pdb:4RW8|rcsb pdb:4RW9|rcsb pdb:5AGZ|rcsb pdb:5AH6|rcsb pdb:5AH8|rcsb pdb:5AH9|rcsb pdb:5AHA|rcsb pdb:5AHB|rcsb pdb:5AHC|rcsb pdb:5TXL|rcsb pdb:5TXM|rcsb pdb:5TXN|rcsb pdb:5TXO|rcsb pdb:5TXP|rcsb pdb:4YE3|rcsb pdb:4YHQ|rcsb pdb:4KO0|rcsb pdb:4KKO|rcsb pdb:5BRY|rcsb pdb:5BS4|rcsb pdb:5CYM|rcsb pdb:5CYQ|rcsb pdb:5JFP|rcsb pdb:5JFU|rcsb pdb:5JG1|interpro:IPR034170|rcsb pdb:6C8X|rcsb pdb:6C8Y|rcsb pdb:6HAK|rcsb pdb:6OE3|rcsb pdb:6AMO|rcsb pdb:6AN2|rcsb pdb:6AN8|rcsb pdb:6ANQ|rcsb pdb:6AOC|rcsb pdb:6ASW|rcsb pdb:6AVM|rcsb pdb:6AVT|rcsb pdb:6C0J|rcsb pdb:6C0K|rcsb pdb:6C0L|rcsb pdb:6C0N|rcsb pdb:6C0O|rcsb pdb:6C0P|rcsb pdb:6C0R|rcsb pdb:6CGF|rcsb pdb:6DUF|rcsb pdb:6DUG|rcsb pdb:6DUH|rcsb pdb:5UFZ|rcsb pdb:6B19|rcsb pdb:6BZ2|rcsb pdb:5OI2|rcsb pdb:5OI3|rcsb pdb:5OI5|rcsb pdb:5OI8|rcsb pdb:5OIA|rcsb pdb:5YOJ|interpro:IPR043502|rcsb pdb:6DTW|rcsb pdb:6DTX|rcsb pdb:6ECL|rcsb pdb:6OUN|rcsb pdb:6O48|interpro:IPR043128|rcsb pdb:6UL5|rcsb pdb:6KMP|rcsb pdb:6VUG refseq:NP_003698.1|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9Y265|rcsb pdb:2C9O|rcsb pdb:2XSZ|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-606279|ensembl:ENSG00000175792(gene)|ensembl:ENSG00000284901(gene)|ensembl:ENST00000322623(transcript)|ensembl:ENST00000643444(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001306013.1|dip:DIP-29937N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:Mp/WUBSNFoTdVaUPeE/ZUtGI50E11678 rogid:+FA/xQTUldQoWGRgad9U8vZpTHw9606 intact-crc:66873FFCA319BB45|rigid:IxJBGahXfL1I70MvWeMkoBJCTA8 false sufficient binding region:500-1447("MI:0442")|tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q92805 intact:EBI-6248094 intact:EBI-6164177|ensembl:ENSP00000362656|uniprotkb:Q5T164|uniprotkb:Q8IYZ9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:goga1_human(display_long)|uniprotkb:GOLGA1(gene name)|psi-mi:GOLGA1(display_short)|uniprotkb:Golgin-97(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000136935(gene)|ensembl:ENST00000373555(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|refseq:NP_002068.1|refseq:XP_006717125.1|refseq:XP_006717126.1|refseq:XP_005251986.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:5SRVVvNxZ7PikOK9zV4HypxK8i49606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q86X55 intact:EBI-6248094 intact:EBI-2339854|uniprotkb:A6NN38|ensembl:ENSP00000325690 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:carm1_human(display_long)|uniprotkb:CARM1(gene name)|psi-mi:CARM1(display_short)|uniprotkb:PRMT4(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 4(gene name synonym)|uniprotkb:Coactivator-associated arginine methyltransferase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_954592.1|refseq:XP_005259765.1|dip:DIP-44071N|ensembl:ENSG00000142453(gene)|ensembl:ENST00000327064(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008469"(histone-arginine N-methyltransferase activity)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034970"(histone H3-R2 methylation)|go:"GO:0034971"(histone H3-R17 methylation)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0035642"("histone methyltransferase activity (H3-R17 specific)")|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:1902415"(regulation of mRNA binding)|go:"GO:2000171"(negative regulation of dendrite development)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020989|interpro:IPR025799|interpro:IPR029063|mint:Q86X55|rcsb pdb:2Y1W|rcsb pdb:2Y1X|rcsb pdb:4IKP|rcsb pdb:5DWQ|rcsb pdb:5DX0|rcsb pdb:5DX1|rcsb pdb:5DX8|rcsb pdb:5DXA|rcsb pdb:5DXJ|rcsb pdb:5U4X|rcsb pdb:6ARJ|rcsb pdb:6ARV|rcsb pdb:6D2L|rcsb pdb:6DVR|rcsb pdb:6IZQ|rcsb pdb:6S70|rcsb pdb:6S71|rcsb pdb:6S74|rcsb pdb:6S77|rcsb pdb:6S79|rcsb pdb:6S7A|rcsb pdb:6S7B|rcsb pdb:6S7C|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-3214858|reactome:R-HSA-381340|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-6804114|reactome:R-HSA-9018519|reactome:R-HSA-9707564|reactome:R-HSA-9707616|go:"GO:0051591"(response to cAMP) psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:1x1bUjqcA/ZpmrSsSM545ReYH2A9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8TF40 intact:EBI-6248094 intact:EBI-2946919|ensembl:ENSP00000421985|uniprotkb:Q9BUT0|uniprotkb:Q86T47|uniprotkb:D6RJH5 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:fnip1_human(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q8TF40|reactome:R-HSA-9639288|go:"GO:0032008"(positive regulation of TOR signaling)|refseq:NP_001008738.2|refseq:NP_588613.2|refseq:NP_001333042.1|dip:DIP-57169N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O15371 intact:EBI-6248094 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8N163 intact:EBI-6248094 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P60228 intact:EBI-6248094 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9Y262 intact:EBI-6248094 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P32121 intact:EBI-6248094 intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9NRF9 intact:EBI-6248094 intact:EBI-744901|uniprotkb:Q5W0U1|uniprotkb:Q8N758|uniprotkb:Q8NCE5|uniprotkb:Q9NR32|ensembl:ENSP00000363284|ensembl:ENSP00000363286 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe3_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p17(gene name synonym)|uniprotkb:Chromatin accessibility complex 17 kDa protein(gene name synonym)|uniprotkb:Arsenic-transactivated protein(gene name synonym)|uniprotkb:POLE3(gene name)|psi-mi:POLE3(display_short)|uniprotkb:CHRAC17(gene name synonym)|uniprotkb:DNA polymerase II subunit 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001265184.1|refseq:NP_059139.3|ensembl:ENSG00000148229(gene)|ensembl:ENST00000374169(transcript)|ensembl:ENST00000374171(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:eTI1XsrypxKqml09tm4GAImoZgI9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UGP4 intact:EBI-6248094 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q12874 intact:EBI-6248094 intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:fNjNguUOXqApr46rOAEpTs2geqY9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q86US8 intact:EBI-6248094 intact:EBI-3232100|ensembl:ENSP00000263073|uniprotkb:O94837|uniprotkb:Q9UF60|uniprotkb:Q86VH6|uniprotkb:B7Z874 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:est1a_human(display_long)|uniprotkb:SMG6(gene name)|psi-mi:SMG6(display_short)|uniprotkb:C17orf31(gene name synonym)|uniprotkb:EST1A(gene name synonym)|uniprotkb:KIAA0732(gene name synonym)|uniprotkb:EST1-like protein A(gene name synonym)|uniprotkb:Ever shorter telomeres 1A(gene name synonym)|uniprotkb:Smg-6 homolog(gene name synonym)|uniprotkb:Telomerase subunit EST1A(gene name synonym)|uniprotkb:hSmg5/7a(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENST00000263073(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0035303"(regulation of dephosphorylation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051972"(regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018834|interpro:IPR019458|interpro:IPR029060|mint:Q86US8|rcsb pdb:2DOK|rcsb pdb:2HWW|rcsb pdb:2HWX|rcsb pdb:4UM2|reactome:R-HSA-975957|ensembl:ENSG00000070366(gene)|refseq:XP_011522071.1|refseq:XP_011522077.1|refseq:NP_060045.4|refseq:NP_001243756.1|refseq:NP_001243757.1|refseq:NP_001269255.1|refseq:XP_005256626.1|refseq:XP_005256628.1|refseq:XP_016879888.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:UoAA9ikMFv3EHZZozUAOkWWPrRM9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99996 intact:EBI-6248094 intact:EBI-1048311|uniprotkb:O14869|uniprotkb:O43355|uniprotkb:O94895|uniprotkb:Q75N20|uniprotkb:Q9UQH3|uniprotkb:Q9UQQ4|uniprotkb:Q9Y6B8|uniprotkb:A4D1F0|uniprotkb:Q9Y6Y2|uniprotkb:A4D1F2|uniprotkb:A4D1F4|ensembl:ENSP00000348573 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:akap9_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)|uniprotkb:A-kinase anchor protein 450 kDa(gene name synonym)|uniprotkb:A-kinase anchor protein 350 kDa(gene name synonym)|uniprotkb:AKAP 120-like protein(gene name synonym)|uniprotkb:Protein hyperion(gene name synonym)|uniprotkb:Protein yotiao(gene name synonym)|uniprotkb:Centrosome- and Golgi-localized PKN-associated protein(gene name synonym)|uniprotkb:AKAP9(gene name)|psi-mi:AKAP9(display_short)|uniprotkb:AKAP350(gene name synonym)|uniprotkb:AKAP450(gene name synonym)|uniprotkb:KIAA0803(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_005742.4|refseq:NP_671714.1|ensembl:ENSG00000127914(gene)|ensembl:ENST00000356239(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044307"(dendritic branch)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|interpro:IPR005539(ELK)|interpro:IPR019528|interpro:IPR028745|mint:Q99996|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5576890|reactome:R-HSA-5576893|reactome:R-HSA-5620912|reactome:R-HSA-6802952|reactome:R-HSA-8854518|ensembl:ENSP00000348573|ensembl:ENST00000680766|ensembl:ENSP00000505204|dip:DIP-29942N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:LQUNbTHUgEsjayFEZvczC4e90Nw9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:P33991 intact:EBI-6248094 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q07864 intact:EBI-6248094 intact:EBI-348526|uniprotkb:Q13533|intact:EBI-28987244|ensembl:ENSP00000322570|uniprotkb:Q86VH9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe1_human(display_long)|uniprotkb:POLE(gene name)|psi-mi:POLE(display_short)|uniprotkb:POLE1(gene name synonym)|uniprotkb:DNA polymerase II subunit A(gene name synonym)|uniprotkb:3'-5' exodeoxyribonuclease(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006222.2|go:"GO:0008310"(single-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0045004"(DNA replication proofreading)|go:"GO:0048568"(embryonic organ development)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013697(Region of unknown function DUF1744)|interpro:IPR029703|interpro:IPR036397|interpro:IPR042087|interpro:IPR043502|rcsb pdb:5VBN|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962|go:"GO:0008270"(zinc ion binding)|ensembl:ENSG00000177084(gene)|ensembl:ENST00000320574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006297"(nucleotide-excision repair, DNA gap filling)|ensembl:ENSP00000322570|dip:DIP-24243N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:oPDFCAO2AeDB4UjbeBvo8DPi+ow9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9H4L5 intact:EBI-6248094 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9HBG6 intact:EBI-6248094 intact:EBI-2805994|uniprotkb:B3KW53|uniprotkb:B4DEY9|uniprotkb:B4DPW7|uniprotkb:E7EQF4|uniprotkb:E9PDG2|uniprotkb:E9PDX2|uniprotkb:H7C3C0|uniprotkb:Q8TC06|uniprotkb:Q9NV68|uniprotkb:Q9UF80|uniprotkb:Q9HAT9|uniprotkb:Q53G36|ensembl:ENSP00000324005|uniprotkb:Q9BTB9|uniprotkb:Q9BTY4|uniprotkb:G3XAB1|uniprotkb:Q9HBG5 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:if122_human(display_long)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001267475.1|refseq:NP_060732.2|refseq:NP_443711.2|refseq:NP_443715.1|ensembl:ENST00000348417(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030991"(intraciliary transport particle A)|ensembl:ENSG00000163913(gene)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039857|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_443716.1|refseq:NP_001267470.1|refseq:NP_001267474.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+CItPDBES/UTyqgLedVcoHfVCcM9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q14152 intact:EBI-6248094 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q9UBQ5 intact:EBI-6248094 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q8NFG4 intact:EBI-6248094 intact:EBI-2970160|ensembl:ENSP00000285071|uniprotkb:Q96BD2|uniprotkb:Q96BE4|uniprotkb:A6NJJ8|uniprotkb:Q6ZRX1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:flcn_human(display_long)|uniprotkb:FLCN(gene name)|psi-mi:FLCN(display_short)|uniprotkb:BHD(gene name synonym)|uniprotkb:BHD skin lesion fibrofolliculoma protein(gene name synonym)|uniprotkb:Birt-Hogg-Dube syndrome protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010823"(negative regulation of mitochondrion organization)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031929"(TOR signaling)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097009"(energy homeostasis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1901723"(negative regulation of cell proliferation involved in kidney development)|go:"GO:1903444"(negative regulation of brown fat cell differentiation)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:2000973"(regulation of pro-B cell differentiation)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR021713|interpro:IPR032035|interpro:IPR037520|interpro:IPR037521|interpro:IPR044886|rcsb pdb:3V42|rcsb pdb:6NZD|rcsb pdb:6ULG|reactome:R-HSA-9639288|ensembl:ENSG00000154803(gene)|ensembl:ENST00000285071(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|refseq:NP_653207.1|refseq:NP_659434.2|refseq:XP_016879795.1|refseq:XP_016879796.1|refseq:XP_016879797.1|dip:DIP-61287N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:gd59RCSQ6ssRdb2wz+HZl1V5wLY9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:Q99613 intact:EBI-6248094 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Q2G4 uniprotkb:O15372 intact:EBI-6248094 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177860|imex:IM-17346-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2018/04/30 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:D7C976B2AA804F9A|rigid:Xj+ChQ7Wc10n9jsXq4IuToRiNRk false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q7L2J0 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371983|uniprotkb:Q9NPD4|uniprotkb:B3KP86|uniprotkb:D6W5V7|ensembl:ENSP00000308546 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:mepce_human(display_long)|uniprotkb:MEPCE(gene name)|psi-mi:MEPCE(display_short)|uniprotkb:BCDIN3(gene name synonym)|uniprotkb:Bicoid-interacting protein 3 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:XP_011514712.1|refseq:NP_001181919.1|refseq:NP_001181920.1|refseq:NP_001181921.1|refseq:NP_062552.2|ensembl:ENSG00000146834(gene)|ensembl:ENST00000310512(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0017069"(snRNA binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0040031"(snRNA modification)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990276"(RNA 5'-methyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772|mint:Q7L2J0|rcsb pdb:5UNA|rcsb pdb:6DCB|rcsb pdb:6DCC psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:VGhJoO3FD7nsJPVSBsKuKsPJzEM9606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q99733 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2255116|uniprotkb:B2R6J4|uniprotkb:F5HFY4|ensembl:ENSP00000369915|ensembl:ENSP00000483728 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:np1l4_human(display_long)|uniprotkb:NAP1L4(gene name)|psi-mi:NAP1L4(display_short)|uniprotkb:NAP2(gene name synonym)|uniprotkb:Nucleosome assembly protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_005960.1|ensembl:ENSG00000205531(gene)|ensembl:ENSG00000273562(gene)|ensembl:ENST00000380542(transcript)|ensembl:ENST00000619695(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q99733 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.75 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:tES8IJDlW4JONR/pdC8dq49I/7Y9606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P51825 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O60563 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:P50750 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:O43865 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P04608 uniprotkb:Q4G0J3 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371923|uniprotkb:B2ZHN6|uniprotkb:Q3B7A9|uniprotkb:Q9P1S7|uniprotkb:Q9Y3Z8|intact:EBI-2560173|ensembl:ENSP00000314311|ensembl:ENSP00000344950|ensembl:ENSP00000499190 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:larp7_human(display_long)|uniprotkb:LARP7(gene name)|psi-mi:LARP7(display_short)|uniprotkb:La ribonucleoprotein domain family member 7(gene name synonym)|uniprotkb:P-TEFb-interaction protein for 7SK stability(gene name synonym)|uniprotkb:HDCMA18P(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6177970|imex:IM-17346-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_056269.1|refseq:NP_057732.2|refseq:NP_001253968.1|dip:DIP-47624N|ensembl:ENSG00000174720(gene)|ensembl:ENST00000324052(transcript)|ensembl:ENST00000344442(transcript)|ensembl:ENST00000651579(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000494"(box C/D RNA 3'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990438"(U6 2'-O-snRNA methylation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002344(Lupus La protein)|interpro:IPR006630(RNA-binding protein Lupus La)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR014886(RNA binding motif)|interpro:IPR034887|interpro:IPR034910|interpro:IPR034946|interpro:IPR035979|interpro:IPR036388|interpro:IPR036390|mint:Q4G0J3|rcsb pdb:4WKR|rcsb pdb:5KNW|rcsb pdb:6D12 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:ZIHCyGk7VI4irQOPvTXcNjk2ifw9606 intact-crc:9287F86A5CF4CE86|rigid:YvjfKPdOS/9+UW1zsAIeWn2IjqI false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:P25686 intact:EBI-779991 intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9Y5V3 intact:EBI-779991 intact:EBI-716006|uniprotkb:Q5VSH6|uniprotkb:Q8IZ84|uniprotkb:Q8WY92|uniprotkb:Q9H352|uniprotkb:Q9HBT4|uniprotkb:Q9UF36|ensembl:ENSP00000325333|ensembl:ENSP00000364874|ensembl:ENSP00000364927 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:magd1_human(display_long)|uniprotkb:MAGE-D1 antigen(gene name synonym)|uniprotkb:Neurotrophin receptor-interacting MAGE homolog(gene name synonym)|uniprotkb:MAGE tumor antigen CCF(gene name synonym)|uniprotkb:MAGED1(gene name)|psi-mi:MAGED1(display_short)|uniprotkb:NRAGE(gene name synonym)|uniprotkb:PRO2292(orf name)|uniprotkb:PP2250(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001005332.1|refseq:NP_001005333.1|refseq:NP_008917.3|ensembl:ENSP00000325333|ensembl:ENST00000375695|ensembl:ENSP00000364847|ensembl:ENSP00000364874|ensembl:ENSP00000364927|refseq:XP_011529137.1|refseq:XP_016885467.1|refseq:XP_016885468.1|refseq:XP_016885469.1|ensembl:ENSG00000179222(gene)|ensembl:ENST00000326587(transcript)|ensembl:ENST00000375722(transcript)|ensembl:ENST00000375772(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR002190(MAGE protein)|interpro:IPR030083|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9Y5V3|reactome:R-HSA-193648|reactome:R-HSA-418889 psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:UTg0r4zGMXfTZqBN4SFmgu6IukI9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q93034 intact:EBI-779991 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N psi-mi:"MI:0096"(pull down) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9UBF6 intact:EBI-779991 intact:EBI-398632|uniprotkb:Q9BXN8|uniprotkb:Q9Y5M7|uniprotkb:A8MTB5|uniprotkb:A8K1H9|uniprotkb:D3DNF7|uniprotkb:D3DNF8|uniprotkb:C9JYL3|ensembl:ENSP00000273480 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:rbx2_human(display_long)|uniprotkb:RNF7(gene name)|psi-mi:RNF7(display_short)|uniprotkb:RBX2(gene name synonym)|uniprotkb:ROC2(gene name synonym)|uniprotkb:SAG(gene name synonym)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Regulator of cullins 2(gene name synonym)|uniprotkb:CKII beta-binding protein 1(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_055060.1|refseq:NP_899060.1|refseq:NP_001188299.1|ensembl:ENSG00000114125(gene)|ensembl:ENST00000273480(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|go:"GO:0051775"(response to redox state)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|rcsb pdb:2ECL|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) - author-confidence:0.95 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:FNop0ozErv05khKc5si7nNH/Hww9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0096"(pull down) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15369 intact:EBI-779991 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0096"(pull down) - author-confidence:0.97 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q13617 intact:EBI-779991 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0096"(pull down) - author-confidence:0.89 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q15370 intact:EBI-779991 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N psi-mi:"MI:0096"(pull down) - author-confidence:0.92 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q8TEB1 intact:EBI-779991 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12504 uniprotkb:Q9C0C7 intact:EBI-779991 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178002|imex:IM-17346-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:E97C3A4683905372|rigid:+XppVPZCEho5KxuD9qZZGssZJH0 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:O75179 intact:EBI-6164519 intact:EBI-355530|uniprotkb:Q6PJ85|uniprotkb:Q6PK85|uniprotkb:Q6PKA2|uniprotkb:Q86XI3|uniprotkb:Q8NDR5|uniprotkb:Q96I86|uniprotkb:Q9H6J9|uniprotkb:Q9H288|ensembl:ENSP00000351416|uniprotkb:G5E964|uniprotkb:E7EUV3 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:anr17_human(display_long)|uniprotkb:ANKRD17(gene name)|psi-mi:ANKRD17(display_short)|uniprotkb:GTAR(gene name synonym)|uniprotkb:KIAA0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-16(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_115593.3|refseq:NP_942592.1|refseq:NP_056389.1|ensembl:ENSG00000132466(gene)|ensembl:ENST00000358602(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:O75179|go:"GO:0031965"(nuclear membrane)|refseq:NP_001273700.1|ensembl:ENST00000330838|ensembl:ENSP00000332265|ensembl:ENSP00000351416|ensembl:ENST00000509867|ensembl:ENSP00000427151|dip:DIP-47290N psi-mi:"MI:0096"(pull down) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:l/gkMCasWF6pn6feuIzeQKWwwKM9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9BT78 intact:EBI-6164519 intact:EBI-742413|uniprotkb:Q561W7|uniprotkb:Q9NW31|uniprotkb:Q9Y677|uniprotkb:B3KN88|ensembl:ENSP00000264389|uniprotkb:B3KST5 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:csn4_human(display_long)|uniprotkb:COPS4(gene name)|psi-mi:COPS4(display_short)|uniprotkb:CSN4(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000138663(gene)|refseq:NP_057213.2|refseq:NP_001244935.1|go:"GO:0016607"(nuclear speck)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:Q9BT78|rcsb pdb:4D0P|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|ensembl:ENST00000264389(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|refseq:NP_001317656.1|dip:DIP-34516N psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:onrZiPzG+bZvycmpDTZMtkPzCfQ9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q8WXD5 intact:EBI-6164519 intact:EBI-752301|uniprotkb:Q53SI5|uniprotkb:Q8WVB4|uniprotkb:Q9H5G6|uniprotkb:B2RDP8|ensembl:ENSP00000281950 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:gemi6_human(display_long)|uniprotkb:SIP2(gene name synonym)|uniprotkb:GEMIN6(gene name)|psi-mi:GEMIN6(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_079051.9|dip:DIP-41331N|ensembl:ENSG00000152147(gene)|ensembl:ENST00000281950(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR009422(Gemin6)|mint:Q8WXD5|rcsb pdb:1Y96|rcsb pdb:7BBL|reactome:R-HSA-191859 psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:AaQyOsKgOMpkny7dYKmgwu0/c1g9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q14204 intact:EBI-6164519 intact:EBI-356015|intact:EBI-4399546|uniprotkb:Q6DKQ7|uniprotkb:Q8WU28|uniprotkb:Q92814|uniprotkb:Q9Y4G5|uniprotkb:B0I1R0|intact:EBI-28969816|ensembl:ENSP00000348965 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dyhc1_human(display_long)|uniprotkb:DYNC1H1(gene name)|psi-mi:DYNC1H1(display_short)|uniprotkb:DNECL(gene name synonym)|uniprotkb:KIAA0325(gene name synonym)|uniprotkb:DNCH1(gene name synonym)|uniprotkb:DNCL(gene name synonym)|uniprotkb:DHC1(gene name synonym)|uniprotkb:DYHC(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001367.2|ensembl:ENSP00000348965|ensembl:ENSG00000197102(gene)|ensembl:ENST00000360184(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|mint:Q14204|rcsb pdb:2BOR|rcsb pdb:2BOT|rcsb pdb:5NUG|rcsb pdb:5OWO|rcsb pdb:6F1T|rcsb pdb:6F1U|rcsb pdb:6F1V|rcsb pdb:6F1Y|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|dip:DIP-37544N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:nI5RCxHByU3dxtLnPMPEjJlx1Fc9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y4B6 intact:EBI-6164519 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0096"(pull down) - author-confidence:0.88 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9Y6G9 intact:EBI-6164519 intact:EBI-2556107|uniprotkb:A2RRG7|uniprotkb:Q53HK7|uniprotkb:Q53HC8|ensembl:ENSP00000273130 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1l1_human(display_long)|uniprotkb:DNCLI1(gene name synonym)|uniprotkb:Dynein light intermediate chain 1, cytosolic(gene name synonym)|uniprotkb:Dynein light chain A(gene name synonym)|uniprotkb:DYNC1LI1(gene name)|psi-mi:DYNC1LI1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_057225.2|ensembl:ENSG00000144635(gene)|ensembl:ENST00000273130(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0045504"(dynein heavy chain binding)|go:"GO:0051301"(cell division)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR008467(Dynein light intermediate chain)|interpro:IPR022780|interpro:IPR027417|mint:Q9Y6G9|rcsb pdb:6B9H|rcsb pdb:6PSD|rcsb pdb:6PSE|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0007018"(microtubule-based movement) psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:LxQSfBpzuf6Acus2jBy0s53FdhU9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16531 intact:EBI-6164519 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q9BW61 intact:EBI-6164519 intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N psi-mi:"MI:0096"(pull down) - author-confidence:0.90 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q16576 intact:EBI-6164519 intact:EBI-352227|ensembl:ENSP00000369427|intact:EBI-3505029|uniprotkb:Q5JP00 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:rbbp7_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:RBAP46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_002884.1|ensembl:ENST00000380087(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q16576|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:7M3X|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8951664|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|ensembl:ENSG00000102054(gene)|refseq:NP_001185648.1|dip:DIP-436N psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P12520 uniprotkb:Q13409 intact:EBI-6164519 intact:EBI-742998|ensembl:ENSP00000380308|ensembl:ENSP00000386415|uniprotkb:Q96NG7|uniprotkb:Q96S87|uniprotkb:Q9BXZ5|uniprotkb:Q9NT58|uniprotkb:Q32LY9|uniprotkb:Q53S84|uniprotkb:Q5BJF8|uniprotkb:Q7Z4X1|uniprotkb:D3DPD4|uniprotkb:D3DPD5|uniprotkb:D3DPD6|uniprotkb:B7ZA04 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dc1i2_human(display_long)|uniprotkb:Cytoplasmic dynein intermediate chain 2(gene name synonym)|uniprotkb:Dynein intermediate chain 2, cytosolic(gene name synonym)|uniprotkb:DYNC1I2(gene name)|psi-mi:DYNC1I2(display_short)|uniprotkb:DNCIC2(gene name synonym)|uniprotkb:DNCI2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178040|imex:IM-17346-65 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 ensembl:ENSG00000077380(gene)|ensembl:ENST00000397119(transcript)|ensembl:ENST00000409773(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0010970"(transport along microtubule)|go:"GO:0031982"(vesicle)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0045504"(dynein heavy chain binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR025956|interpro:IPR036322|mint:Q13409|reactome:R-HSA-380270|rcsb pdb:5JPW|reactome:R-HSA-380284|rcsb pdb:6F1T|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|rcsb pdb:6F1U|rcsb pdb:6F1Z|rcsb pdb:6F38|rcsb pdb:6F3A|reactome:R-HSA-141444|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|refseq:NP_001369.1|refseq:NP_001258714.1|refseq:NP_001258717.1|refseq:NP_001258718.1|refseq:NP_001258719.1|refseq:NP_001258715.1|refseq:NP_001307811.1|refseq:NP_001307812.1|refseq:NP_001307813.1|refseq:NP_001258716.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:dTj7k9h8BQ+etwfwsE2MEY2nXRM9606 intact-crc:A4F881A93F6C0938|rigid:8eANFeVTfONZHIbDl9zin9w5PSg false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q86T03 intact:EBI-6248147 intact:EBI-6164623|uniprotkb:B2RA35|uniprotkb:Q86U09|uniprotkb:Q8WUC0|uniprotkb:Q9BU67|uniprotkb:Q9NSU8|ensembl:ENSP00000250489 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:pp4p1_human(display_long)|uniprotkb:PIP4P1(gene name)|psi-mi:PIP4P1(display_short)|uniprotkb:C14orf9(gene name synonym)|uniprotkb:PtdIns-4,5-P2 4-Ptase I(gene name synonym)|uniprotkb:TMEM55B(gene name synonym)|uniprotkb:Transmembrane protein 55B(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSP00000250489|ensembl:ENST00000398020|ensembl:ENSP00000381102|refseq:NP_001094284.1|refseq:NP_653169.2|ensembl:ENSG00000165782(gene)|ensembl:ENST00000250489(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0034597"(phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0070070"(proton-transporting V-type ATPase complex assembly)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR019178|reactome:R-HSA-6811555|reactome:R-HSA-8847453 psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nbc8AvBd7g6bpNjfhhK7aPZ0BYk9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96F15 intact:EBI-6248147 intact:EBI-6166686|ensembl:ENSP00000351473|ensembl:ENSP00000487840|uniprotkb:D3DWZ5|uniprotkb:Q6IA75|uniprotkb:Q96NE4|uniprotkb:Q9NUK9 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:gima5_human(display_long)|uniprotkb:GIMAP5(gene name)|psi-mi:GIMAP5(display_short)|uniprotkb:IAN4L1(gene name synonym)|uniprotkb:IAN5(gene name synonym)|uniprotkb:IMAP3(gene name synonym)|uniprotkb:Immunity-associated nucleotide 4-like 1 protein(gene name synonym)|uniprotkb:Immunity-associated nucleotide 5 protein(gene name synonym)|uniprotkb:Immunity-associated protein 3(gene name synonym)|uniprotkb:Immune-associated nucleotide-binding protein 5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000196329(gene)|ensembl:ENST00000358647(transcript)|ensembl:ENST00000498181(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032585"(multivesicular body membrane)|interpro:IPR006703(AIG1)|interpro:IPR027417|refseq:NP_060854.2|dip:DIP-59484N psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:DchT8vcce8oKbvAQeC2nbxH17Xg9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P40939 intact:EBI-6248147 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q5T9A4 intact:EBI-6248147 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UHQ9 intact:EBI-6248147 intact:EBI-953870|ensembl:ENSP00000356218|uniprotkb:A0PK21|uniprotkb:O95329|uniprotkb:Q53F73|uniprotkb:Q8NCL5|uniprotkb:Q9UHJ1|uniprotkb:B2R8E0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:nb5r1_human(display_long)|uniprotkb:"NAD(P)H:quinone oxidoreductase type 3 polypeptide A2"(gene name synonym)|uniprotkb:Humb5R2(gene name synonym)|uniprotkb:CYB5R1(gene name)|psi-mi:CYB5R1(display_short)|uniprotkb:NQO3A2(gene name synonym)|uniprotkb:UNQ3049/PRO9865(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000159348(gene)|ensembl:ENST00000367249(transcript)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071949"(FAD binding)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR001834("NADH:cytochrome b5 reductase (CBR)")|interpro:IPR008333(Oxidoreductase FAD-binding region)|interpro:IPR017927|interpro:IPR017938|interpro:IPR039261|reactome:R-HSA-114608|reactome:R-HSA-1237044|go:"GO:0016020"(membrane)|refseq:NP_057327.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:TOvJYSyfYu73Ac/SYjup+ABu74g9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P55084 intact:EBI-6248147 intact:EBI-356635|uniprotkb:Q9T2V8|uniprotkb:O14969|uniprotkb:Q53TA6|uniprotkb:Q96C77|uniprotkb:Q9H3F5|uniprotkb:B2RB16|intact:EBI-2948478|ensembl:ENSP00000325136|intact:EBI-8012123|intact:MINT-8395035|uniprotkb:B4E2W0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:echb_human(display_long)|uniprotkb:HADHB(gene name)|psi-mi:HADHB(display_short)|uniprotkb:MSTP029(orf name)|uniprotkb:TP-beta(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_000174.1|ensembl:ENSG00000138029(gene)|ensembl:ENST00000317799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003988"(acetyl-CoA C-acyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005740"(mitochondrial envelope)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0050633"(acetyl-CoA C-myristoyltransferase activity)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|mint:P55084|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350|refseq:XP_011531105.1|refseq:NP_001268441.1|refseq:NP_001268442.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:4w0QYaw1wLyr5NJOKZ9naymK8kg9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P42695 intact:EBI-6248147 intact:EBI-722805|uniprotkb:A6NFS2|uniprotkb:Q4KMQ9|ensembl:ENSP00000433681 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cndd3_human(display_long)|uniprotkb:Non-SMC condensin II complex subunit D3(gene name synonym)|uniprotkb:NCAPD3(gene name)|psi-mi:NCAPD3(display_short)|uniprotkb:CAPD3(gene name synonym)|uniprotkb:KIAA0056(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_056076.1|dip:DIP-43903N|ensembl:ENSG00000151503(gene)|ensembl:ENST00000534548(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0051301"(cell division)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012371(Chromosome condensation protein, HCP-6-related)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026971|interpro:IPR032682|mint:P42695|reactome:R-HSA-2299718 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:z5WYLlrGt33uAM9NRN9SQeHFDaA9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q15185 intact:EBI-6248147 intact:EBI-1049387|uniprotkb:Q8WU70|intact:EBI-9357271|uniprotkb:B4DHP2|uniprotkb:B4DP11|uniprotkb:B4DP21|uniprotkb:A8K7D0|ensembl:ENSP00000262033 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:tebp_human(display_long)|uniprotkb:Cytosolic prostaglandin E2 synthase(gene name synonym)|uniprotkb:Telomerase-binding protein p23(gene name synonym)|uniprotkb:Progesterone receptor complex p23(gene name synonym)|uniprotkb:PTGES3(gene name)|psi-mi:PTGES3(display_short)|uniprotkb:P23(gene name synonym)|uniprotkb:TEBP(gene name synonym)|uniprotkb:Hsp90 co-chaperone(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001269530.1|refseq:NP_001269531.1|refseq:NP_001269532.1|refseq:NP_001269533.1|refseq:NP_001269534.1|refseq:NP_006592.3|dip:DIP-279N|ensembl:ENSG00000110958(gene)|ensembl:ENST00000262033(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0003720"(telomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019371"(cyclooxygenase pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043588"(skin development)|go:"GO:0050220"(prostaglandin-E synthase activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060430"(lung saccule development)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0101031"(chaperone complex)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|mint:Q15185|rcsb pdb:1EJF|reactome:R-HSA-2162123|reactome:R-HSA-3371497|reactome:R-HSA-3371511|reactome:R-HSA-3371568|reactome:R-HSA-8937144|reactome:R-HSA-8939211|reactome:R-HSA-9018519|reactome:R-HSA-9679191|rcsb pdb:1LG0 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:6NuM7BPG39XzwqdKBCr74uuumCo9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UBB4 intact:EBI-6248147 intact:EBI-702390|uniprotkb:O14998|uniprotkb:O15009|uniprotkb:Q6I9X4|uniprotkb:A6NLC4|uniprotkb:B4DG05|ensembl:ENSP00000252934 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atx10_human(display_long)|uniprotkb:Spinocerebellar ataxia type 10 protein(gene name synonym)|uniprotkb:Brain protein E46 homolog(gene name synonym)|uniprotkb:ATXN10(gene name)|psi-mi:ATXN10(display_short)|uniprotkb:SCA10(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001161093.1|refseq:NP_037368.1|ensembl:ENSG00000130638(gene)|ensembl:ENST00000252934(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060271"(cilium assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019156|mint:Q9UBB4 psi-mi:"MI:0096"(pull down) - author-confidence:0.80 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:kQ+1aM5ZEzIlpH2lKWFGVSrCDww9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P18859 intact:EBI-6248147 intact:EBI-2606700|ensembl:ENSP00000284971|ensembl:ENSP00000382959|ensembl:ENSP00000382962|ensembl:ENSP00000382965|ensembl:ENSP00000382966|uniprotkb:J3KQ83 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atp5j_human(display_long)|uniprotkb:ATP5PF(gene name)|psi-mi:ATP5PF(display_short)|uniprotkb:ATP synthase peripheral stalk subunit F6(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5J(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001003696.1|refseq:NP_001003697.1|refseq:NP_001003701.1|refseq:NP_001003703.1|refseq:NP_001676.2|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0009986"(cell surface)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032307"(negative regulation of prostaglandin secretion)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:1900139"(negative regulation of arachidonic acid secretion)|interpro:IPR008387(ATPase, F0 complex, subunit F6, mitochondrial)|interpro:IPR036204|mint:P18859|reactome:R-HSA-163210|reactome:R-HSA-8949613|ensembl:ENSG00000154723(gene)|ensembl:ENST00000284971(transcript)|ensembl:ENST00000400087(transcript)|ensembl:ENST00000400090(transcript)|ensembl:ENST00000400093(transcript)|ensembl:ENST00000400094(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|refseq:NP_001307195.1|refseq:NP_001307196.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0swdCmCT2TBep9+xToVV0Ntl2ZA9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NQC3 intact:EBI-6248147 intact:EBI-715945|intact:EBI-1753019|uniprotkb:O94962|uniprotkb:Q9BXG5|uniprotkb:Q9H212|uniprotkb:Q9H3I3|uniprotkb:Q9UQ42|uniprotkb:Q9Y293|uniprotkb:Q9Y2Y7|uniprotkb:Q9Y5U6|intact:EBI-1958210|intact:EBI-1056082|uniprotkb:Q7L7Q8|uniprotkb:Q96B16|intact:EBI-28967519|ensembl:ENSP00000337838|uniprotkb:Q7L7Q5|uniprotkb:Q7L7Q6|uniprotkb:Q8IUA4 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn4_human(display_long)|uniprotkb:Neurite outgrowth inhibitor(gene name synonym)|uniprotkb:Foocen(gene name synonym)|uniprotkb:Neuroendocrine-specific protein(gene name synonym)|uniprotkb:Neuroendocrine-specific protein C homolog(gene name synonym)|uniprotkb:RTN-x(gene name synonym)|uniprotkb:Reticulon-5(gene name synonym)|uniprotkb:RTN4(gene name)|psi-mi:RTN4(display_short)|uniprotkb:KIAA0886(gene name synonym)|uniprotkb:NOGO(gene name synonym)|uniprotkb:My043(orf name)|uniprotkb:SP1507(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000317610|ensembl:ENSP00000322147|ensembl:ENSP00000337838|ensembl:ENST00000357376|ensembl:ENSP00000349944|ensembl:ENST00000357732|ensembl:ENSP00000350365|ensembl:ENST00000394609|ensembl:ENSP00000378107|ensembl:ENST00000394611|ensembl:ENSP00000378109|ensembl:ENST00000404909|ensembl:ENSP00000385650|ensembl:ENST00000405240|ensembl:ENSP00000384471|refseq:NP_008939.1|refseq:NP_065393.1|refseq:NP_722550.1|refseq:NP_997403.1|refseq:NP_997404.1|ensembl:ENSG00000115310(gene)|ensembl:ENST00000337526(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0021801"(cerebral cortex radial glia-guided migration)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061462"(protein localization to lysosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:0090156"(cellular sphingolipid homeostasis)|go:"GO:0098826"(endoplasmic reticulum tubular network membrane)|go:"GO:0120078"(cell adhesion involved in sprouting angiogenesis)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902624"(positive regulation of neutrophil migration)|go:"GO:1905523"(positive regulation of macrophage migration)|go:"GO:1905552"(positive regulation of protein localization to endoplasmic reticulum)|go:"GO:1905580"(positive regulation of ERBB3 signaling pathway)|go:"GO:1905653"(positive regulation of artery morphogenesis)|go:"GO:1990809"(endoplasmic reticulum tubular network membrane organization)|go:"GO:2000172"(regulation of branching morphogenesis of a nerve)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001213"(negative regulation of vasculogenesis)|interpro:IPR003388(Reticulon)|mint:Q9NQC3|rcsb pdb:2G31|rcsb pdb:2JV5|reactome:R-HSA-193634|refseq:XP_005264491.1|refseq:NP_001308788.1|refseq:NP_001308789.1|refseq:NP_001308790.1|refseq:NP_001308791.1|refseq:NP_001308792.1|refseq:NP_001308833.1|refseq:XP_016860007.1|refseq:XP_016860008.1|dip:DIP-42003N psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:uhivTNOPdC7+q81CliY0Ozu0EwA9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P48047 intact:EBI-6248147 intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9NVI7 intact:EBI-6248147 intact:EBI-352007|ensembl:ENSP00000368030|uniprotkb:Q5SV23|uniprotkb:Q8N275|uniprotkb:Q96A50|uniprotkb:B3KPB3|uniprotkb:D2K8Q1|uniprotkb:G3V1I6 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atd3a_human(display_long)|uniprotkb:ATAD3A(gene name)|psi-mi:ATAD3A(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001164006.1|refseq:NP_001164007.1|refseq:NP_060658.3|ensembl:ENSG00000197785(gene)|ensembl:ENST00000378755(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q9NVI7|dip:DIP-33194N psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:IZKJEVLLS/DFINgBgO5frizN1P49606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P06576 intact:EBI-6248147 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q63HN8 intact:EBI-6248147 intact:EBI-1058832|intact:EBI-1059339|uniprotkb:Q8TEU0|uniprotkb:Q9H6C9|uniprotkb:C9JCP4|uniprotkb:D6RI12|uniprotkb:F8WKS1|uniprotkb:Q658P6|uniprotkb:Q6MZR1|uniprotkb:Q9H6H9|uniprotkb:Q9H6P3|uniprotkb:Q9H8A9|uniprotkb:Q9HCF4|uniprotkb:Q9HCL8|uniprotkb:Q69YK7|uniprotkb:Q8IWF4|uniprotkb:Q8IZX1|uniprotkb:Q8IZX2|uniprotkb:Q8N406 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rn213_human(display_long)|uniprotkb:RING-type E3 ubiquitin transferase RNF213(gene name synonym)|uniprotkb:RNF213(gene name)|psi-mi:RNF213(display_short)|uniprotkb:ALK lymphoma oligomerization partner on chromosome 17(gene name synonym)|uniprotkb:ALO17(gene name synonym)|uniprotkb:C17orf27(gene name synonym)|uniprotkb:KIAA1554(gene name synonym)|uniprotkb:KIAA1618(gene name synonym)|uniprotkb:MYSTR(gene name synonym)|uniprotkb:Mysterin(gene name synonym)|uniprotkb:RING finger protein 213(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018957|go:"GO:0001525"(angiogenesis)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|reactome:R-HSA-9635465|reactome:R-HSA-983168|refseq:NP_001243000.2|interpro:IPR027417|refseq:NP_066005.2|ensembl:ENST00000319921|ensembl:ENSP00000324392|ensembl:ENSG00000173821|interpro:IPR031248|mint:Q63HN8 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:M5TG5F1xZSNNeYTLh0H6WMqUHGs9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q96P70 intact:EBI-6248147 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z psi-mi:"MI:0096"(pull down) - author-confidence:0.81 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q13616 intact:EBI-6248147 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0096"(pull down) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O14828 intact:EBI-6248147 intact:EBI-4401333|ensembl:ENSP00000307275|ensembl:ENSP00000461521|uniprotkb:A9Z1W6|uniprotkb:B1AVS6|uniprotkb:O15128|uniprotkb:Q96FR8|uniprotkb:Q9BPY0 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:scam3_human(display_long)|uniprotkb:SCAMP3(gene name)|psi-mi:SCAMP3(display_short)|uniprotkb:C1orf3(gene name synonym)|uniprotkb:PROPIN1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENSG00000116521(gene)|ensembl:ENSG00000263290(gene)|ensembl:ENST00000302631(transcript)|ensembl:ENST00000570831(transcript)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007273(SCAMP)|mint:O14828|ensembl:ENSP00000307275|ensembl:ENST00000355379|ensembl:ENSP00000347540|ensembl:ENSP00000461521|ensembl:ENST00000573013|ensembl:ENSP00000458542|refseq:NP_005689.2|refseq:NP_443069.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.83 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:q1GaoVa7cLS2hGHVUM5Nv2oX4x09606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q99653 intact:EBI-6248147 intact:EBI-722721|uniprotkb:Q6FHZ9|uniprotkb:B2R6H9|ensembl:ENSP00000335632 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:chp1_human(display_long)|uniprotkb:CHP1(gene name)|psi-mi:CHP1(display_short)|uniprotkb:CHP(gene name synonym)|uniprotkb:Calcineurin B-like protein(gene name synonym)|uniprotkb:Calcium-binding protein CHP(gene name synonym)|uniprotkb:Calcium-binding protein p22(gene name synonym)|uniprotkb:EF-hand calcium-binding domain-containing protein p22(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_009167.1|ensembl:ENSG00000187446(gene)|ensembl:ENST00000334660(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006903"(vesicle targeting)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0010923"(negative regulation of phosphatase activity)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019900"(kinase binding)|go:"GO:0022406"(membrane docking)|go:"GO:0030133"(transport vesicle)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0060050"(positive regulation of protein glycosylation)|go:"GO:0061024"(membrane organization)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071073"(positive regulation of phospholipid biosynthetic process)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:2E30|rcsb pdb:7DSV|rcsb pdb:7DSX|reactome:R-HSA-2160916 psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:6/VeERuA4F0QeWlUj0pN8u0E6hc9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q8TC07 intact:EBI-6248147 intact:EBI-1048247|uniprotkb:B9A6L6|intact:EBI-6190229|uniprotkb:B4DMT9|uniprotkb:J3KNI9|uniprotkb:Q9HA83|intact:EBI-28984447|ensembl:ENSP00000448182 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:tbc15_human(display_long)|uniprotkb:TBC1D15(gene name)|psi-mi:TBC1D15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001139685.2|refseq:NP_001139686.1|refseq:NP_073608.4|ensembl:ENST00000319106|ensembl:ENSP00000318262|ensembl:ENST00000485960|ensembl:ENSP00000420678|ensembl:ENSP00000448182|ensembl:ENSG00000121749(gene)|ensembl:ENST00000550746(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-HSA-8854214 psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:3tlqjLtZ/Bq5H6M00sHIwqNqqw49606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9GZT3 intact:EBI-6248147 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 psi-mi:"MI:0096"(pull down) - author-confidence:0.87 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P24539 intact:EBI-6248147 intact:EBI-1044810|uniprotkb:Q9BQ68|uniprotkb:Q9BRU8|ensembl:ENSP00000358737 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:at5f1_human(display_long)|uniprotkb:ATP5PB(gene name)|psi-mi:ATP5PB(display_short)|uniprotkb:ATP synthase peripheral stalk-membrane subunit b(gene name synonym)|uniprotkb:"ATP synthase proton-transporting mitochondrial F(0) complex subunit B1"(gene name synonym)|uniprotkb:ATP synthase subunit b(gene name synonym)|uniprotkb:ATP5F1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001679.2|ensembl:ENSG00000116459(gene)|ensembl:ENST00000369722(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0015078"(proton transmembrane transporter activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0021762"(substantia nigra development)|interpro:IPR008688(ATPase, F0 complex, subunit B, mitochondrial)|interpro:IPR013837(ATPase, F0 complex subunit B, mitochondrial, metazoa)|mint:P24539|reactome:R-HSA-163210|reactome:R-HSA-8949613|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport) psi-mi:"MI:0096"(pull down) - author-confidence:0.82 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:n1HuorsLzONcID7ccOL9qEsODLE9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q86XR8 intact:EBI-6248147 intact:EBI-308614|uniprotkb:Q14704|uniprotkb:Q8IXP0|uniprotkb:Q9BVF9|uniprotkb:Q5JB46|uniprotkb:A0PJH1|uniprotkb:A8K5D0|uniprotkb:B4DDP5|ensembl:ENSP00000317902|uniprotkb:F5H5F7 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:cep57_human(display_long)|uniprotkb:CEP57(gene name)|psi-mi:CEP57(display_short)|uniprotkb:Testis-specific protein 57(gene name synonym)|uniprotkb:Translokin(gene name synonym)|uniprotkb:FGF2-interacting protein(gene name synonym)|uniprotkb:KIAA0092(gene name synonym)|uniprotkb:TSP57(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 go:"GO:0007286"(spermatid development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR010597(Protein of unknown function DUF1167)|interpro:IPR024957|interpro:IPR025913|rcsb pdb:4L0R|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|ensembl:ENSG00000166037(gene)|ensembl:ENST00000325542(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|refseq:NP_055494.2|refseq:NP_001230705.1|refseq:NP_001230706.1|refseq:XP_016874081.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.76 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:zlDjuw8lnfiXHeOeieJPekAcxD09606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P63208 intact:EBI-6248147 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N psi-mi:"MI:0096"(pull down) - author-confidence:0.84 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P13598 intact:EBI-6248147 intact:EBI-2806056|ensembl:ENSP00000464665|uniprotkb:Q14600|ensembl:ENSP00000388666|ensembl:ENSP00000392634|ensembl:ENSP00000415283|ensembl:ENSP00000462579 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:icam2_human(display_long)|uniprotkb:ICAM2(gene name)|psi-mi:ICAM2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 ensembl:ENST00000412356(transcript)|ensembl:ENST00000418105(transcript)|ensembl:ENST00000449662(transcript)|ensembl:ENST00000579687(transcript)|ensembl:ENST00000579788(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015653(Intercellular adhesion molecule 2)|interpro:IPR036179|rcsb pdb:1ZXQ|reactome:R-HSA-198933|reactome:R-HSA-216083|reactome:R-HSA-5621575|refseq:NP_000864.2|refseq:NP_001093256.1|refseq:NP_001093257.1|refseq:NP_001093258.1|refseq:NP_001093259.1|ensembl:ENSG00000108622(gene) psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:46FxUe9wv2WIelobimN/4k+qSS89606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P26038 intact:EBI-6248147 intact:EBI-528768|ensembl:ENSP00000353408 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:moes_human(display_long)|uniprotkb:Membrane-organizing extension spike protein(gene name synonym)|uniprotkb:MSN(gene name)|psi-mi:MSN(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_002435.1|ensembl:ENSG00000147065(gene)|ensembl:ENST00000360270(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001931"(uropod)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0031982"(vesicle)|go:"GO:0042098"(T cell proliferation)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070489"(T cell aggregation)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009986"(cell surface)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0072562"(blood microparticle)|go:"GO:0072678"(T cell migration)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000401"(regulation of lymphocyte migration)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26038|rcsb pdb:1E5W|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016323"(basolateral plasma membrane)|rcsb pdb:1EF1|rcsb pdb:1SGH|rcsb pdb:6TXQ|go:"GO:0016324"(apical plasma membrane)|rcsb pdb:6TXS|reactome:R-HSA-437239|reactome:R-HSA-8950505|reactome:R-HSA-9662360|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-9662361|go:"GO:0019901"(protein kinase binding)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0031143"(pseudopodium)|go:"GO:0031528"(microvillus membrane)|dip:DIP-33841N psi-mi:"MI:0096"(pull down) - author-confidence:0.77 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:XYzuC8VtaVyNYyZ2G5wVbxyPPww9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:Q9UKB1 intact:EBI-6248147 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N psi-mi:"MI:0096"(pull down) - author-confidence:0.85 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P42704 intact:EBI-6248147 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0096"(pull down) - author-confidence:0.91 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P78527 intact:EBI-6248147 intact:EBI-352053|uniprotkb:P78528|uniprotkb:Q13327|uniprotkb:Q13337|uniprotkb:Q14175|uniprotkb:Q59H99|uniprotkb:Q7Z611|uniprotkb:Q96SE6|uniprotkb:Q9UME3|ensembl:ENSP00000313420 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:prkdc_human(display_long)|uniprotkb:PRKDC(gene name)|psi-mi:PRKDC(display_short)|uniprotkb:HYRC(gene name synonym)|uniprotkb:HYRC1(gene name synonym)|uniprotkb:DNPK1(gene name synonym)|uniprotkb:p460(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001075109.1|refseq:NP_008835.5|ensembl:ENSG00000253729(gene)|ensembl:ENST00000314191(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001756"(somitogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002328"(pro-B cell differentiation)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004677"(DNA-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005958"(DNA-dependent protein kinase-DNA ligase 4 complex)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016233"(telomere capping)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031648"(protein destabilization)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0033153"("T cell receptor V(D)J recombination")|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048511"(rhythmic process)|go:"GO:0048536"(spleen development)|go:"GO:0048538"(thymus development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:2001229"(negative regulation of response to gamma radiation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|go:"GO:0097681"(double-strand break repair via alternative nonhomologous end joining)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012582(NUC194)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR036940|interpro:IPR037706|mint:P78527|go:"GO:0106310"(protein serine kinase activity)|rcsb pdb:5LUQ|rcsb pdb:5W1R|rcsb pdb:5Y3R|rcsb pdb:6ZFP|rcsb pdb:6ZH2|rcsb pdb:6ZH4|go:"GO:0106311"|rcsb pdb:6ZH6|rcsb pdb:6ZH8|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7K0Y|rcsb pdb:7K10|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|rcsb pdb:7K11|rcsb pdb:7K19|go:"GO:1905221"(positive regulation of platelet formation)|rcsb pdb:7K1B|rcsb pdb:7K1J|go:"GO:2000773"(negative regulation of cellular senescence)|rcsb pdb:7K1K|go:"GO:2001034"(positive regulation of double-strand break repair via nonhomologous end joining)|rcsb pdb:7K1N|rcsb pdb:7LT3|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-8866654|ensembl:ENSP00000313420|ensembl:ENST00000338368|ensembl:ENSP00000345182|dip:DIP-24186N psi-mi:"MI:0096"(pull down) - author-confidence:0.78 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:WKXDHilQTGO8zQRd8ZcMYha99PM9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:O95197 intact:EBI-6248147 intact:EBI-740467|intact:EBI-28977804|ensembl:ENSP00000367050|uniprotkb:Q147U9|uniprotkb:Q496K2|uniprotkb:Q53GN3|uniprotkb:Q59EP0|uniprotkb:Q5UEP2|uniprotkb:Q6T930|uniprotkb:Q7RTM7|uniprotkb:Q7RTM8|uniprotkb:Q7RTN3|uniprotkb:B3KQS2|uniprotkb:B7Z308|intact:EBI-11081390|uniprotkb:B7Z4M0|uniprotkb:F5H774 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:rtn3_human(display_long)|uniprotkb:Neuroendocrine-specific protein-like 2(gene name synonym)|uniprotkb:Neuroendocrine-specific protein-like II(gene name synonym)|uniprotkb:RTN3(gene name)|psi-mi:RTN3(display_short)|uniprotkb:NSPL2(gene name synonym)|uniprotkb:ASYIP(gene name synonym)|uniprotkb:Homolog of ASY protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001252518.1|refseq:NP_006045.1|refseq:NP_958831.1|refseq:NP_958832.1|refseq:NP_958833.1|ensembl:ENSG00000133318(gene)|ensembl:ENST00000377819(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:O95197|rcsb pdb:7BRU|reactome:R-HSA-8849932|ensembl:ENSP00000348279|ensembl:ENSP00000367050|ensembl:ENST00000537981|ensembl:ENSP00000440874|ensembl:ENST00000540798|ensembl:ENSP00000442733|ensembl:ENST00000339997|ensembl:ENSP00000344106|ensembl:ENST00000341307|ensembl:ENSP00000340903|ensembl:ENST00000354497|ensembl:ENSP00000346492|ensembl:ENST00000356000|refseq:NP_001252519.1|refseq:NP_001252520.1 psi-mi:"MI:0096"(pull down) - author-confidence:0.86 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:nlwcgOle9rsXe2uha2//mQlB4Do9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P05919 uniprotkb:P30049 intact:EBI-6248147 intact:EBI-1049505|uniprotkb:Q6FG90|uniprotkb:D6W5Y3|ensembl:ENSP00000215375|ensembl:ENSP00000378995|ensembl:ENSP00000464863 psi-mi:vpu_hv1h2(display_long)|uniprotkb:vpu(gene name)|psi-mi:vpu(display_short)|uniprotkb:U ORF protein(gene name synonym)|uniprotkb:Viral protein U(gene name synonym) psi-mi:atpd_human(display_long)|uniprotkb:ATP5F1D(gene name)|psi-mi:ATP5F1D(display_short)|uniprotkb:ATP synthase F1 subunit delta(gene name synonym)|uniprotkb:ATP5D(gene name synonym)|uniprotkb:F-ATPase delta subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178081|imex:IM-17346-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005261"(cation channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019076"(viral release from host cell)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0042609"(CD4 receptor binding)|rcsb pdb:2N29|interpro:IPR008187(Vpu protein)|interpro:IPR009032(Vpu protein, cytoplasmic)|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-171286|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180534|reactome:R-HSA-180689|reactome:R-HSA-180910 refseq:NP_001001975.1|refseq:NP_001678.1|ensembl:ENSG00000099624(gene)|ensembl:ENST00000215375(transcript)|ensembl:ENST00000395633(transcript)|ensembl:ENST00000591660(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009060"(aerobic respiration)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0033615"(mitochondrial proton-transporting ATP synthase complex assembly)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0046688"(response to copper ion)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|interpro:IPR001469(ATPase, F1 complex, delta/epsilon subunit)|interpro:IPR020546|interpro:IPR036771|interpro:IPR036794|mint:P30049|reactome:R-HSA-163210|reactome:R-HSA-8949613 psi-mi:"MI:0096"(pull down) - author-confidence:0.79 figure legend:suppl. data 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2012/07/09 2014/10/16 rogid:XK4KRsKZk7lI2CT3iw8gKYOtOEU11706 rogid:OA8if7wpjwV6hkkaLqPyz6YDljc9606 intact-crc:CDA60A4A507687BB|rigid:RWhHxujIYuYpiR2a+Il4gxqSrt4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y3B7 uniprotkb:P04591-PRO_0000038596 intact:EBI-5453723|ensembl:ENSP00000308897|uniprotkb:A8K219|uniprotkb:Q32P46|uniprotkb:Q96Q73|uniprotkb:A6NLT0 intact:EBI-6179727 psi-mi:rm11_human(display_long)|uniprotkb:MRPL11(gene name)|psi-mi:MRPL11(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL11m(gene name synonym)|uniprotkb:CGI-113(orf name) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178187|imex:IM-17346-67 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000174547(gene)|ensembl:ENST00000310999(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015934"(large ribosomal subunit)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|interpro:IPR000911(Ribosomal protein L11)|interpro:IPR006519(Ribosomal protein L11, bacterial-type)|interpro:IPR020783|interpro:IPR020784|interpro:IPR036769|interpro:IPR036796|mint:Q9Y3B7|refseq:NP_057134.1|refseq:NP_733934.1|refseq:NP_733935.1|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6NU3|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:eTr4vzze0vg1fxw97n9C/lXYssU9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:3776CFEB4BAE98F9|rigid:OMeRQYWph9wv5pfY+z/u2wMbPwk false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q7Z739 uniprotkb:P04591-PRO_0000038596 intact:EBI-2849837|uniprotkb:Q659A3|uniprotkb:B3KXL4|uniprotkb:Q63Z37|ensembl:ENSP00000473496 intact:EBI-6179727 psi-mi:ythd3_human(display_long)|uniprotkb:YTHDF3(gene name)|psi-mi:YTHDF3(display_short) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178204|imex:IM-17346-68 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_689971.4|refseq:NP_001264742.1|refseq:NP_001264743.1|refseq:NP_001264744.1|refseq:NP_001264745.1|refseq:NP_001264746.1|refseq:NP_001264747.1|ensembl:ENSG00000185728(gene)|ensembl:ENST00000539294(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1901163"(regulation of trophoblast cell migration)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q7Z739|rcsb pdb:6ZOT intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:M1/1RMOQiQ7kD+J9KMmEq9RZebw9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:11A4A6CD0EC62E56|rigid:/ydD0Fnv7cr1hylLzNL2yjAeQr0 false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04591 uniprotkb:Q15427 intact:EBI-6163428 intact:EBI-348469|ensembl:ENSP00000271628|intact:EBI-1047735|uniprotkb:Q5SZ63 psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:sf3b4_human(display_long)|uniprotkb:SF3B4(gene name)|psi-mi:SF3B4(display_short)|uniprotkb:SAP49(gene name synonym)|uniprotkb:Spliceosome-associated protein 49(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 49 kDa subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178221|imex:IM-17346-69 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) refseq:NP_005841.1|ensembl:ENSG00000143368(gene)|ensembl:ENST00000271628(transcript)|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:6AHD|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|go:"GO:0000375"(RNA splicing, via transesterification reactions)|interpro:IPR034159|interpro:IPR035979|mint:Q15427|rcsb pdb:1X5T|rcsb pdb:5GVQ|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0 psi-mi:"MI:0096"(pull down) - - figure legend:S10a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 rogid:Jgy6WmBFKkphpZLLte2GgsagUVI9606 intact-crc:9392BB9398E78C49|rigid:dhADzKRf6cw9xAlxOLpmNTjgk8g false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q15427 uniprotkb:P04591-PRO_0000038596 intact:EBI-348469|ensembl:ENSP00000271628|intact:EBI-1047735|uniprotkb:Q5SZ63 intact:EBI-6179727 psi-mi:sf3b4_human(display_long)|uniprotkb:SF3B4(gene name)|psi-mi:SF3B4(display_short)|uniprotkb:SAP49(gene name synonym)|uniprotkb:Spliceosome-associated protein 49(gene name synonym)|uniprotkb:Pre-mRNA-splicing factor SF3b 49 kDa subunit(gene name synonym) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178234|imex:IM-17346-70 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005841.1|ensembl:ENSG00000143368(gene)|ensembl:ENST00000271628(transcript)|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:6AHD|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:1990935"(splicing factor binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034158|go:"GO:0000375"(RNA splicing, via transesterification reactions)|interpro:IPR034159|interpro:IPR035979|mint:Q15427|rcsb pdb:1X5T|rcsb pdb:5GVQ|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:Jgy6WmBFKkphpZLLte2GgsagUVI9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:61550E1F104D92CB|rigid:SFBymm5EQWKFhKCjDhFV6kPWYQI false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P55769 uniprotkb:P04591-PRO_0000038596 intact:EBI-712228|ensembl:ENSP00000215956|ensembl:ENSP00000383949|ensembl:ENSP00000497142 intact:EBI-6179727 psi-mi:nh2l1_human(display_long)|uniprotkb:SNU13(gene name)|psi-mi:SNU13(display_short)|uniprotkb:High mobility group-like nuclear protein 2 homolog 1(gene name synonym)|uniprotkb:NHP2L1(gene name synonym)|uniprotkb:OTK27(gene name synonym)|uniprotkb:SNU13 homolog(gene name synonym)|uniprotkb:U4/U6.U5 small nuclear ribonucleoprotein SNU13(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP 15.5 kDa protein(gene name synonym) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178251|imex:IM-17346-71 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100138(gene)|ensembl:ENST00000215956(transcript)|ensembl:ENST00000401959(transcript)|ensembl:ENST00000648674(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0007338"(single fertilization)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051117"(ATPase binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004037(Ribosomal protein L7Ae)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:P55769|rcsb pdb:1E7K|rcsb pdb:2JNB|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-6790901|reactome:R-HSA-6791226|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_001003796.1|refseq:NP_004999.1 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:ZMkqsDfMCrTlT/kJxillOA8839E9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:81D1B8F78D3F2EC3|rigid:9MeFAZTJ23JgyXZ5JFcud7ThFI8 false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q8N1G4 intact:EBI-6179727 intact:EBI-2509921|ensembl:ENSP00000367498|uniprotkb:Q9ULN5 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:lrc47_human(display_long)|uniprotkb:LRRC47(gene name)|psi-mi:LRRC47(display_short)|uniprotkb:KIAA1185(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178268|imex:IM-17346-72 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) ensembl:ENSG00000130764(gene)|ensembl:ENST00000378251(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR025875|interpro:IPR032675|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|refseq:NP_065761.1 psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal - figure legend:S10c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:aPzU//EIwK8J4it97jCw/YyKFWU9606 intact-crc:3BC645DA55DF905D|rigid:JuEf3q5jnqeoEsZJKUFvRMattio false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P19525 uniprotkb:P04591-PRO_0000038596 intact:EBI-640775|uniprotkb:D6W584|uniprotkb:Q52M43|uniprotkb:Q9UIR4|uniprotkb:A8K3P0|ensembl:ENSP00000233057|ensembl:ENSP00000378559|ensembl:ENSP00000497534|ensembl:ENSP00000505138|ensembl:ENSP00000505772|ensembl:ENSP00000506024|uniprotkb:E9PC80|uniprotkb:Q7Z6F6 intact:EBI-6179727 psi-mi:e2ak2_human(display_long)|uniprotkb:Interferon-inducible RNA-dependent protein kinase(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 2(gene name synonym)|uniprotkb:Protein kinase RNA-activated(gene name synonym)|uniprotkb:p68 kinase(gene name synonym)|uniprotkb:P1/eIF-2A protein kinase(gene name synonym)|uniprotkb:EIF2AK2(gene name)|psi-mi:EIF2AK2(display_short)|uniprotkb:PKR(gene name synonym)|uniprotkb:PRKR(gene name synonym)|uniprotkb:Tyrosine-protein kinase EIF2AK2(gene name synonym) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178285|imex:IM-17346-73 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129124.1|refseq:NP_001129123.1|refseq:NP_002750.1|ensembl:ENSG00000055332(gene)|ensembl:ENST00000233057(transcript)|ensembl:ENST00000395127(transcript)|ensembl:ENST00000647926(transcript)|ensembl:ENST00000679507(transcript)|ensembl:ENST00000681463(transcript)|ensembl:ENST00000681507(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044452|interpro:IPR044453|mint:P19525|rcsb pdb:1QU6|rcsb pdb:2A19|rcsb pdb:2A1A|rcsb pdb:3UIU|rcsb pdb:6D3K|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|rcsb pdb:6D3L|reactome:R-HSA-1169408|go:"GO:0051607"(defense response to virus)|reactome:R-HSA-169131|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900225"(regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902033"(regulation of hematopoietic stem cell proliferation)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|dip:DIP-2657N|refseq:XP_011531289.1 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:2Pc405Bc/xKDHC1O24GhGC5JJzU9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:34278963A01A993C|rigid:h4NhcsIk7JLzg3m/aP90L9OeQZE false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Y6V7 uniprotkb:P04591-PRO_0000038596 intact:EBI-719274|uniprotkb:Q53FJ1|uniprotkb:E7ENA0|uniprotkb:Q9BVQ8|ensembl:ENSP00000247003 intact:EBI-6179727 psi-mi:ddx49_human(display_long)|uniprotkb:DEAD box protein 49(gene name synonym)|uniprotkb:DDX49(gene name)|psi-mi:DDX49(display_short) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178302|imex:IM-17346-74 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061943.2|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|ensembl:ENST00000247003(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006364"(rRNA processing)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9Y6V7|go:"GO:0030307"(positive regulation of cell growth)|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0044357"(regulation of rRNA stability)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|ensembl:ENSG00000105671(gene) intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:Yfej1zXpPTue3eewQcR5OpNILeM9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:DE0EDC1ECC0EAAAD|rigid:6Bxxf8DYTiJSQaCTkvYYvGSyXdY false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UI47 uniprotkb:P04591-PRO_0000038596 intact:EBI-3937546|uniprotkb:Q6P056|uniprotkb:Q5VSR2|ensembl:ENSP00000389714|ensembl:ENSP00000508047|ensembl:ENSP00000508371 intact:EBI-6179727 psi-mi:ctna3_human(display_long)|uniprotkb:CTNNA3(gene name)|psi-mi:CTNNA3(display_short)|uniprotkb:Alpha T-catenin(gene name synonym)|uniprotkb:Cadherin-associated protein(gene name synonym) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178319|imex:IM-17346-75 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000183230(gene)|ensembl:ENST00000433211(transcript)|ensembl:ENST00000682758(transcript)|ensembl:ENST00000684154(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|refseq:NP_001120856.1|refseq:NP_037398.2 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:lN7D/dH5lMAkRUKOIXZkdvZSK9E9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:A99693BBC60D4004|rigid:46CTydBkhvIHj41kFPhNJB7u/iQ false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q99873 uniprotkb:P04591-PRO_0000038596 intact:EBI-78738|intact:EBI-949313|uniprotkb:A0A087X1W2|uniprotkb:H7C2I1|uniprotkb:Q15529|uniprotkb:Q99872|uniprotkb:Q99874|uniprotkb:Q9NZ04|uniprotkb:Q9NZ05|uniprotkb:Q9NZ06|ensembl:ENSP00000406162|intact:EBI-2622582|uniprotkb:B4E3C3|uniprotkb:G5E9B6|uniprotkb:Q8WUW5|uniprotkb:Q2VP93|uniprotkb:Q6LEU5|intact:EBI-11034520|intact:EBI-6137914 intact:EBI-6179727 psi-mi:anm1_human(display_long)|uniprotkb:PRMT1(gene name)|psi-mi:PRMT1(display_short)|uniprotkb:Interferon receptor 1-bound protein 4(gene name synonym)|uniprotkb:Histone-arginine N-methyltransferase PRMT1(gene name synonym)|uniprotkb:HMT2(gene name synonym)|uniprotkb:HRMT1L2(gene name synonym)|uniprotkb:IR1B4(gene name synonym) psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178336|imex:IM-17346-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126457(gene)|ensembl:ENST00000454376(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008170"(N-methyltransferase activity)|go:"GO:0008276"(protein methyltransferase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018216"(peptidyl-arginine methylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0034709"(methylosome)|go:"GO:0035241"(protein-arginine omega-N monomethyltransferase activity)|go:"GO:0035242"(protein-arginine omega-N asymmetric methyltransferase activity)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043985"(histone H4-R3 methylation)|go:"GO:0044020"("histone methyltransferase activity (H4-R3 specific)")|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051260"(protein homooligomerization)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904047"(S-adenosyl-L-methionine binding)|interpro:IPR025799|interpro:IPR029063|interpro:IPR041698|mint:Q99873|rcsb pdb:6NT2|reactome:R-HSA-3214858|reactome:R-HSA-6804114|reactome:R-HSA-8936459|reactome:R-HSA-9009391|reactome:R-HSA-9018519|refseq:NP_001527.3|refseq:NP_938074.2|refseq:XP_016882223.1|refseq:XP_016882224.1|refseq:NP_001193971.1|dip:DIP-30878N intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal figure legend:S10a, S10c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2018/04/06 rogid:8I7isKQC9YJTBzPz1Qve4V8l8Xg9606 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 intact-crc:A8ED82AC045C5962|rigid:NNuUkT1mqnSyd4pMuKriOevkXR4 false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9HD40 uniprotkb:P04591-PRO_0000038593 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 intact:EBI-6179719 psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178353|imex:IM-17346-77 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:S10a, S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:0E780F3F627E3620|rigid:MO3xx+OC2Xt0JXaITth1tAQQJzQ false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q86SQ7 uniprotkb:P04591-PRO_0000038593 intact:EBI-1047850|uniprotkb:Q3ZCR6|uniprotkb:Q8N5F2|uniprotkb:Q9P0F1|uniprotkb:O60527|ensembl:ENSP00000355499|ensembl:ENSP00000483550 intact:EBI-6179719 psi-mi:sdcg8_human(display_long)|uniprotkb:Antigen NY-CO-8(gene name synonym)|uniprotkb:Centrosomal colon cancer autoantigen protein(gene name synonym)|uniprotkb:SDCCAG8(gene name)|psi-mi:SDCCAG8(display_short)|uniprotkb:CCCAP(gene name synonym)|uniprotkb:NPHP10(gene name synonym)|uniprotkb:HSPC085(orf name) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178370|imex:IM-17346-78 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006633.1|ensembl:ENSG00000054282(gene)|ensembl:ENSG00000276111(gene)|ensembl:ENST00000366541(transcript)|ensembl:ENST00000622598(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030030"(cell projection organization)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035148"(tube formation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0097733"(photoreceptor cell cilium)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR031887|mint:Q86SQ7|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_005273080.1 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:Z3ynDtbmAV7usLzKH+M3Ilf6Ebw9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:F83356C45C1E1874|rigid:N7XZZsstEjnou0emQHw5Y62bZi4 false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NTK5 uniprotkb:P04591-PRO_0000038593 intact:EBI-766468|uniprotkb:Q5BJD7|uniprotkb:Q8NCI8|uniprotkb:Q96CU1|uniprotkb:Q96SV2|uniprotkb:Q9P1D3|uniprotkb:Q9UNY9|uniprotkb:Q9Y6G4|uniprotkb:D7EHM2|ensembl:ENSP00000284719 intact:EBI-6179719 psi-mi:ola1_human(display_long)|uniprotkb:GTPBP9(gene name synonym)|uniprotkb:GTP-binding protein 9(gene name synonym)|uniprotkb:OLA1(gene name)|psi-mi:OLA1(display_short)|uniprotkb:PTD004(orf name)|uniprotkb:PRO2455(orf name)|uniprotkb:DNA damage-regulated overexpressed in cancer 45(gene name synonym) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178387|imex:IM-17346-79 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001011708.1|refseq:NP_037473.3|dip:DIP-34591N|ensembl:ENST00000284719(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR004095(TGS)|interpro:IPR004396(Conserved hypothetical protein CHP00092)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR013029(Protein of unknown function DUF933)|interpro:IPR023192|interpro:IPR027417|interpro:IPR031167|interpro:IPR041706|mint:Q9NTK5|rcsb pdb:2OHF|reactome:R-HSA-114608|ensembl:ENSG00000138430(gene) intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:S10a, S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:aQk5XBcKpx1YSW4mHtyRsTpimvk9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:05653FE41800DB71|rigid:752AvP5gQpwLLb9KLNyyXh73QCY false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43324 uniprotkb:P04591-PRO_0000038593 intact:EBI-1048486|uniprotkb:Q5THS2|ensembl:ENSP00000369038|uniprotkb:C9JLK5 intact:EBI-6179719 psi-mi:mca3_human(display_long)|uniprotkb:Multisynthase complex auxiliary component p18(gene name synonym)|uniprotkb:Elongation factor p18(gene name synonym)|uniprotkb:EEF1E1(gene name)|psi-mi:EEF1E1(display_short)|uniprotkb:P18(gene name synonym)|uniprotkb:AIMP3(gene name synonym)|uniprotkb:Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3(gene name synonym) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178404|imex:IM-17346-80 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129122.1|refseq:NP_004271.1|ensembl:ENSG00000124802(gene)|ensembl:ENST00000379715(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036282|interpro:IPR042450|mint:O43324|rcsb pdb:2UZ8|go:"GO:0043065"(positive regulation of apoptotic process)|rcsb pdb:4BL7|rcsb pdb:4BVX|rcsb pdb:4BVY|rcsb pdb:5BMU|rcsb pdb:5Y6L|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-50581N intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:4AuJouC9q6uAH/4EH8SKSPHyEZU9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:FBBD8165C2261B91|rigid:j69H2/5+8ymfZ2SpoLSy2qNvp2E false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q13155 uniprotkb:P04591-PRO_0000038593 intact:EBI-745226|uniprotkb:Q75MR1|uniprotkb:Q96CZ5|uniprotkb:Q9P1L2|ensembl:ENSP00000223029|uniprotkb:F8W950 intact:EBI-6179719 psi-mi:aimp2_human(display_long)|uniprotkb:Protein JTV-1(gene name synonym)|uniprotkb:AIMP2(gene name)|psi-mi:AIMP2(display_short)|uniprotkb:PRO0992(orf name)|uniprotkb:JTV1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p38(gene name synonym) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178421|imex:IM-17346-81 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006294.2|ensembl:ENSG00000106305(gene)|ensembl:ENST00000223029(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060510"(type II pneumocyte differentiation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903632"(positive regulation of aminoacyl-tRNA ligase activity)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR031889|interpro:IPR036282|interpro:IPR041503|interpro:IPR042360|mint:Q13155|rcsb pdb:4DPG|rcsb pdb:4YCU|rcsb pdb:4YCW|rcsb pdb:5A1N|rcsb pdb:5A34|rcsb pdb:5A5H|rcsb pdb:5Y6L|rcsb pdb:6ILD|rcsb pdb:6IY6|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-2408522|reactome:R-HSA-379716|dip:DIP-34421N|refseq:NP_001313536.1 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:VEBmJjo6t3dBY6mKpmUyVLamJFQ9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:7CF5651AD2621C2A|rigid:cWPVpde1BumS2tl4Gyd4tGlcjUA false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04591-PRO_0000038593 uniprotkb:Q12904 intact:EBI-6179719 intact:EBI-1045802|uniprotkb:Q6FG28|uniprotkb:Q96CQ9|uniprotkb:B4E1S7|uniprotkb:B3KTR2|ensembl:ENSP00000350699|ensembl:ENSP00000499850|ensembl:ENSP00000499921|ensembl:ENSP00000500025|ensembl:ENSP00000500159|ensembl:ENSP00000500170|ensembl:ENSP00000500620|ensembl:ENSP00000500668|ensembl:ENSP00000500732|ensembl:ENSP00000500794 psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:aimp1_human(display_long)|uniprotkb:AIMP1(gene name)|psi-mi:AIMP1(display_short)|uniprotkb:EMAP2(gene name synonym)|uniprotkb:SCYE1(gene name synonym)|uniprotkb:Multisynthase complex auxiliary component p43(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178438|imex:IM-17346-82 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001135887.1|refseq:NP_001135888.1|refseq:NP_004748.2|ensembl:ENSG00000164022(gene)|ensembl:ENST00000358008(transcript)|ensembl:ENST00000671868(transcript)|ensembl:ENST00000671960(transcript)|ensembl:ENST00000672285(transcript)|ensembl:ENST00000672328(transcript)|ensembl:ENST00000672337(transcript)|ensembl:ENST00000672341(transcript)|ensembl:ENST00000672911(transcript)|ensembl:ENST00000673018(transcript)|ensembl:ENST00000673123(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051020"(GTPase binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0070094"(positive regulation of glucagon secretion)|interpro:IPR002547(tRNA-binding region)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q12904|rcsb pdb:1E7Z|rcsb pdb:1EUJ|rcsb pdb:1FL0|rcsb pdb:4R3Z|reactome:R-HSA-2408522|reactome:R-HSA-379716|refseq:XP_016864324.1|refseq:XP_016864325.1 psi-mi:"MI:0096"(pull down) chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal - figure legend:S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 rogid:UtCeSRjFyuuEHUxVF2HkG9RA55k9606 intact-crc:54DA888F48ABC48B|rigid:p8wjbaL23uG1xPFOUD1CzXyeJ4E false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P04591-PRO_0000038596 uniprotkb:Q96I25 intact:EBI-6179727 intact:EBI-740272|uniprotkb:Q96GY6|ensembl:ENSP00000369218|ensembl:ENSP00000388638 psi-mi:p04591-pro_0000038596(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:spf45_human(display_long)|uniprotkb:45 kDa-splicing factor(gene name synonym)|uniprotkb:RNA-binding motif protein 17(gene name synonym)|uniprotkb:RBM17(gene name)|psi-mi:RBM17(display_short)|uniprotkb:SPF45(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178455|imex:IM-17346-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-6163428(chain-parent) refseq:NP_001139019.1|refseq:NP_116294.1|ensembl:ENSG00000134453(gene)|ensembl:ENST00000379888(transcript)|ensembl:ENST00000446108(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0043484"(regulation of RNA splicing)|interpro:IPR000467(D111/G-patch)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034653|interpro:IPR035979|interpro:IPR040052|mint:Q96I25|rcsb pdb:2PE8|rcsb pdb:2PEH|rcsb pdb:5LSO|rcsb pdb:6HIP|reactome:R-HSA-72163|dip:DIP-29409N psi-mi:"MI:0096"(pull down) chain-seq-start:378|chain-seq-end:432|comment:Extra met in N-terminal - figure legend:S10a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:YZ2ky6QRnaIfQFp+/vQfVOK5cGU11706 rogid:Vhyfu0XQEzUpy7smEsSHj1s5O+49606 intact-crc:FD75583A3F2A6EDD|rigid:JFCVdWDZ+BjlVnovpb4jJGyyBn4 false tandem tag:c-c("MI:0677") - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14978 uniprotkb:P04591-PRO_0000038593 intact:EBI-396155|uniprotkb:Q15030|intact:EBI-1055664|uniprotkb:Q9BUV3|uniprotkb:Q5VV70|ensembl:ENSP00000474710 intact:EBI-6179719 psi-mi:nolc1_human(display_long)|uniprotkb:NOLC1(gene name)|psi-mi:NOLC1(display_short)|uniprotkb:KIAA0035(gene name synonym)|uniprotkb:Nucleolar 130 kDa protein(gene name synonym)|uniprotkb:140 kDa nucleolar phosphoprotein(gene name synonym)|uniprotkb:Nucleolar phosphoprotein p130(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 13(gene name synonym)|uniprotkb:NS5ATP13(gene name synonym) psi-mi:p04591-pro_0000038593(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178472|imex:IM-17346-84 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004732.2|refseq:NP_001271317.1|refseq:NP_001271318.1|ensembl:ENSG00000166197(gene)|ensembl:ENST00000605788(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007000"(nucleolus organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0015030"(Cajal body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0062064"(box C/D snoRNP complex binding)|go:"GO:0062065"(box H/ACA snoRNP complex binding)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR007718(SRP40, C-terminal)|mint:Q14978 intact:EBI-6163428(chain-parent) psi-mi:"MI:0096"(pull down) - chain-seq-start:2|chain-seq-end:132|comment:Extra met in N-terminal figure legend:S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:G3ClYMfSSjWsDzkxtahX5lLRzzQ9606 rogid:cxL3HTCPyiZz4b2DVma+e6FFRF011706 intact-crc:0A1BFD81A12699F8|rigid:vhRzFBdErFZW6/7Lr/Zph7+ruSY false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9HD40 uniprotkb:P04591 intact:EBI-6163446|uniprotkb:A8K8W1|uniprotkb:Q0D2P3|uniprotkb:Q17RT1|uniprotkb:Q9NXZ5|uniprotkb:Q9UGM9|uniprotkb:Q9Y353|ensembl:ENSP00000371535 intact:EBI-6163428 psi-mi:spcs_human(display_long)|uniprotkb:SEPSECS(gene name)|psi-mi:SEPSECS(display_short)|uniprotkb:Liver-pancreas antigen(gene name synonym)|uniprotkb:SLA-p35(gene name synonym)|uniprotkb:SLA/LP autoantigen(gene name synonym)|uniprotkb:Selenocysteine synthase(gene name synonym)|uniprotkb:"Selenocysteinyl-tRNA(Sec) synthase"(gene name synonym)|uniprotkb:"Sep-tRNA:Sec-tRNA synthase"(gene name synonym)|uniprotkb:Soluble liver antigen(gene name synonym)|uniprotkb:TRNP48(gene name synonym)|uniprotkb:UGA suppressor tRNA-associated protein(gene name synonym)|uniprotkb:"tRNA(Ser/Sec)-associated antigenic protein"(gene name synonym) psi-mi:gag_hv1h2(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178489|imex:IM-17346-85 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011512148.1|refseq:XP_011512150.1|refseq:NP_058651.3|ensembl:ENSG00000109618(gene)|ensembl:ENST00000382103(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0001514"(selenocysteine incorporation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process")|go:"GO:0098621"(phosphoseryl-selenocysteinyl-tRNA selenium transferase activity)|interpro:IPR008829(Soluble liver antigen/liver pancreas antigen)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019793|interpro:IPR019872|mint:Q9HD40|rcsb pdb:3HL2|rcsb pdb:4ZDL|rcsb pdb:4ZDO|rcsb pdb:4ZDP|reactome:R-HSA-2408557 rcsb pdb:6CQR|rcsb pdb:6CPL|rcsb pdb:6CPN|rcsb pdb:6CPO|rcsb pdb:6CQJ|rcsb pdb:6CQL|rcsb pdb:6CQN|rcsb pdb:6CQQ|rcsb pdb:6ECO|interpro:IPR036875|rcsb pdb:5FJB|rcsb pdb:5I1R|interpro:IPR012344(Lentiviral and alpha-retroviral matrix protein, N-terminal)|interpro:IPR000071(Immunodeficiency lentiviral matrix, N-terminal)|interpro:IPR000721(Retroviral nucleocapsid protein Gag)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR008916(Retrovirus capsid, C-terminal)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR014817(Gag protein p6)|rcsb pdb:1TSQ|rcsb pdb:1TSU|refseq:NP_057850.1|rcsb pdb:6N3J|rcsb pdb:6N3U|rcsb pdb:5IND|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-173107|reactome:R-HSA-174490|reactome:R-HSA-174495|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180910|rcsb pdb:6ZDJ|rcsb pdb:5INC|rcsb pdb:5NME|rcsb pdb:5NMF|rcsb pdb:5NMG|rcsb pdb:5NMH|rcsb pdb:5NMK|rcsb pdb:6EC2|rcsb pdb:6ECN|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019013"(viral nucleocapsid)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042025"(host cell nucleus)|go:"GO:0055036"(virion membrane)|go:"GO:0072494"(host multivesicular body) psi-mi:"MI:0096"(pull down) - - figure legend:S10a, S10b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:1xxyUK7bIUrg8CrosJ+/gdX8nXw9606 rogid:nGwb9dDgtg+PAOx2OMo606pDync11706 intact-crc:C7A06E0A183B1427|rigid:6PImHfGwlJNTNJ8uPDgqh7DhE3c false - tandem tag:c-c("MI:0677") - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9Q2G4 uniprotkb:Q7L2H7 intact:EBI-6248094 intact:EBI-353901|intact:EBI-4289539|intact:EBI-715219|uniprotkb:Q2F836|uniprotkb:Q53HL6|uniprotkb:Q9BXW1|uniprotkb:O60735|uniprotkb:A8K7X4|intact:EBI-2559366|ensembl:ENSP00000436049|intact:EBI-373200|uniprotkb:B4E2Q4 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3m_human(display_long)|uniprotkb:EIF3M(gene name)|psi-mi:EIF3M(display_short)|uniprotkb:HFLB5(gene name synonym)|uniprotkb:PCID1(gene name synonym)|uniprotkb:PCI domain-containing protein 1(gene name synonym)|uniprotkb:Fetal lung protein B5(gene name synonym)|uniprotkb:GA17(orf name)|uniprotkb:PNAS-125(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178507|imex:IM-17346-86 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006351.2|refseq:NP_001294858.1|ensembl:ENSG00000149100(gene)|ensembl:ENST00000531120(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027528|interpro:IPR036390|interpro:IPR040750|mint:Q7L2H7|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31256N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:siTfTDezqWL90pw6xG3xUKfY9n49606 intact-crc:B0BBAD52678A0021|rigid:d/2wEGZMDUDb7p4XUyomC2gr36w false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q99613 intact:EBI-6248094 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178524|imex:IM-17346-87 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:AC9E479E5D0604DF|rigid:kbj/fLaLxosI9f1PI5imDcjCBnM false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:O15371 intact:EBI-6248094 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178541|imex:IM-17346-88 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:C5882711BD65E1C7|rigid:ycAw4PmThFUrg47WbAJDIbMznRQ false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:P60228 intact:EBI-6248094 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178558|imex:IM-17346-89 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:B21A220E5812125B|rigid:I8pj6D3baHc6MZqwRbdfBmrqyyQ false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:O00303 intact:EBI-6248094 intact:EBI-711990|ensembl:ENSP00000431800|ensembl:ENSP00000499218|uniprotkb:Q6IB45|uniprotkb:Q8N978|uniprotkb:A8K0S2 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3f_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Deubiquitinating enzyme eIF3f(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178575|imex:IM-17346-90 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000175390(gene)|ensembl:ENST00000533626(transcript)|ensembl:ENST00000651655(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR027531|interpro:IPR037518|mint:O00303|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_003745.1|dip:DIP-35580N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:dpH1pTcPshcrSjNCdPPnkYiW0YU9606 intact-crc:AB25E7F34EB8FF8A|rigid:gU2FHWeogI2PoH6+V4hcNfF8o54 false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") tandem tag:n-n("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O15372 uniprotkb:Q9Q2G4 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-6248094 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178592|imex:IM-17346-91 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:73FCB901FB83F953|rigid:NIJsBXX3EEGVZVtZc7cWpGgIYQ4 false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14152 uniprotkb:Q9Q2G4 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 intact:EBI-6248094 psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178609|imex:IM-17346-92 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:807E0B7F14E31642|rigid:N6AZjy5Oo8yWnMDEukL6AHzbfTM false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9Y262 intact:EBI-6248094 intact:EBI-373519|uniprotkb:Q53HQ1|uniprotkb:Q53HT4|uniprotkb:Q5QTR1|uniprotkb:Q5TI15|uniprotkb:Q6ICD2|uniprotkb:B2RDG6|uniprotkb:B4DYB2|uniprotkb:G8JLH4|intact:EBI-10970119|ensembl:ENSP00000485663|ensembl:ENSP00000499067 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3l_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:HSPC021(orf name)|uniprotkb:HSPC025(orf name)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:MSTP005(orf name)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178626|imex:IM-17346-93 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_057175.1|refseq:NP_001229852.1|dip:DIP-31172N|ensembl:ENSG00000100129(gene)|ensembl:ENST00000624234(transcript)|ensembl:ENST00000652021(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|mint:Q9Y262|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:C9ES0WpTdEHUkjWeZK/SoDP/dAo9606 intact-crc:7C43834FE33148B3|rigid:ZS6mepJ6CbNvk1T8i1szKeorQBg false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O60610 uniprotkb:Q9Q2G4 intact:EBI-3959709|uniprotkb:Q59FH8|uniprotkb:B7ZKW2|uniprotkb:A6NF18|uniprotkb:Q9UC76|intact:EBI-6137912|uniprotkb:E9PEZ2|uniprotkb:Q17RN4|ensembl:ENSP00000373706 intact:EBI-6248094 psi-mi:diap1_human(display_long)|uniprotkb:DIAPH1(gene name)|psi-mi:DIAPH1(display_short)|uniprotkb:DIAP1(gene name synonym)|uniprotkb:Diaphanous-related formin-1(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178643|imex:IM-17346-94 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001073280.1|refseq:NP_005210.3|ensembl:ENSG00000131504(gene)|ensembl:ENST00000389054(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0071420"(cellular response to histamine)|go:"GO:0072686"(mitotic spindle)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR010465(DRF autoregulatory)|interpro:IPR010472(Diaphanous FH3)|interpro:IPR010473(Diaphanous GTPase-binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR014767(Diaphanous autoregulatory)|interpro:IPR014768(GTPase-binding/formin homology 3)|interpro:IPR015425(Actin-binding FH2)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027653|interpro:IPR042201|mint:O60610|reactome:R-HSA-5663220|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013405|reactome:R-HSA-9035034 go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:m8uSwdWB9ePt8wzBRQBVujfEBfo9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:8C64CA64FE033201|rigid:PWv3oVYvbBuq2Pk2FNfBHaNvC5s false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q8TF40 intact:EBI-6248094 intact:EBI-2946919|ensembl:ENSP00000421985|uniprotkb:Q9BUT0|uniprotkb:Q86T47|uniprotkb:D6RJH5 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:fnip1_human(display_long)|uniprotkb:FNIP1(gene name)|psi-mi:FNIP1(display_short)|uniprotkb:KIAA1961(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178660|imex:IM-17346-95 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSG00000217128(gene)|ensembl:ENST00000510461(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0019899"(enzyme binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031929"(TOR signaling)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0051087"(chaperone binding)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR026156|interpro:IPR028084|interpro:IPR028085|interpro:IPR028086|interpro:IPR037545|mint:Q8TF40|reactome:R-HSA-9639288|go:"GO:0032008"(positive regulation of TOR signaling)|refseq:NP_001008738.2|refseq:NP_588613.2|refseq:NP_001333042.1|dip:DIP-57169N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:HVA3rKbb8nS/97UCKVDCje0xTjw9606 intact-crc:E7104A25ED052C0B|rigid:Ne7ieo0hjuWOioeWNC9VsZlNsDU false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q12948 uniprotkb:Q9Q2G4 intact:EBI-1175253|uniprotkb:Q86UP7|uniprotkb:Q9BYM1|uniprotkb:Q9NUE5|uniprotkb:Q9UDD0|uniprotkb:Q9UP06|ensembl:ENSP00000493906 intact:EBI-6248094 psi-mi:foxc1_human(display_long)|uniprotkb:Forkhead-related protein FKHL7(gene name synonym)|uniprotkb:Forkhead-related transcription factor 3(gene name synonym)|uniprotkb:FOXC1(gene name)|psi-mi:FOXC1(display_short)|uniprotkb:FKHL7(gene name synonym)|uniprotkb:FREAC3(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178677|imex:IM-17346-96 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000645831(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001654"(eye development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|ensembl:ENSG00000054598(gene)|go:"GO:0001822"(kidney development)|go:"GO:0001945"(lymph vessel development)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016477"(cell migration)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021549"(cerebellum development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030203"(glycosaminoglycan metabolic process)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0036438"(maintenance of lens transparency)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0008301"(DNA binding, bending)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0060038"(cardiac muscle cell proliferation)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR018122|interpro:IPR030456|interpro:IPR033067|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR036388|interpro:IPR036390|mint:Q12948|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072010"(glomerular epithelium development)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1901491"(negative regulation of lymphangiogenesis)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902038"(positive regulation of hematopoietic stem cell differentiation)|go:"GO:1902257"(negative regulation of apoptotic process involved in outflow tract morphogenesis)|go:"GO:1904798"(positive regulation of core promoter binding)|ensembl:ENSP00000493906|refseq:NP_001444.2 go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:+HuKwX8xMx86iCQW/a+vy/rWP389606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:FA842AA3B4D04F47|rigid:he15Hy8vJ5AdtTH3WUf9FL/pJ1Y false flag tag:c-c("MI:0518") mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9HBG6 intact:EBI-6248094 intact:EBI-2805994|uniprotkb:B3KW53|uniprotkb:B4DEY9|uniprotkb:B4DPW7|uniprotkb:E7EQF4|uniprotkb:E9PDG2|uniprotkb:E9PDX2|uniprotkb:H7C3C0|uniprotkb:Q8TC06|uniprotkb:Q9NV68|uniprotkb:Q9UF80|uniprotkb:Q9HAT9|uniprotkb:Q53G36|ensembl:ENSP00000324005|uniprotkb:Q9BTB9|uniprotkb:Q9BTY4|uniprotkb:G3XAB1|uniprotkb:Q9HBG5 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:if122_human(display_long)|uniprotkb:SPG(gene name synonym)|uniprotkb:WDR10(gene name synonym)|uniprotkb:WDR140(gene name synonym)|uniprotkb:WD repeat-containing protein 10(gene name synonym)|uniprotkb:WD repeat-containing protein 140(gene name synonym)|uniprotkb:IFT122(gene name)|psi-mi:IFT122(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178694|imex:IM-17346-97 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001267475.1|refseq:NP_060732.2|refseq:NP_443711.2|refseq:NP_443715.1|ensembl:ENST00000348417(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0030991"(intraciliary transport particle A)|ensembl:ENSG00000163913(gene)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0097542"(ciliary tip)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR039857|reactome:R-HSA-5610787|reactome:R-HSA-5620924|refseq:NP_443716.1|refseq:NP_001267470.1|refseq:NP_001267474.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:+CItPDBES/UTyqgLedVcoHfVCcM9606 intact-crc:EFB5651B2DDC9E9C|rigid:C3DkMkgsUf7JjGUJD76JGyrGCD8 false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8N163 uniprotkb:Q9Q2G4 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 intact:EBI-6248094 psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178711|imex:IM-17346-98 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:1DFA0B8672EB718E|rigid:2KU6A2oPZ3ToPdoPz4u4iy7U6/Q false flag tag:c-c("MI:0518") mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UGP4 uniprotkb:Q9Q2G4 intact:EBI-2652871|uniprotkb:Q17RQ1|uniprotkb:Q9BQQ9|uniprotkb:Q9NQ47|ensembl:ENSP00000273317 intact:EBI-6248094 psi-mi:limd1_human(display_long)|uniprotkb:LIMD1(gene name)|psi-mi:LIMD1(display_short) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178728|imex:IM-17346-99 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055055.1|ensembl:ENSG00000144791(gene)|ensembl:ENST00000273317(transcript)|go:"GO:0000932"(P-body)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016310"(phosphorylation)|go:"GO:0016442"(RISC complex)|go:"GO:0016477"(cell migration)|go:"GO:0033962"(P-body assembly)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR028734|reactome:R-HSA-1234176 go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:Eq6aJ83PR4G/LIlUi5H2Bv31sTQ9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:7EC706EC7849065A|rigid:0RPKqJUkVQNRJQhdGgXNx1ll6OA false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9UBQ5 intact:EBI-6248094 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178745|imex:IM-17346-100 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:2BDEA5D20E58FC3B|rigid:cUYDfMbqaEaHe92f+i9j5pZphTg false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9NR33 intact:EBI-6248094 intact:EBI-867034|uniprotkb:Q53TR2|ensembl:ENSP00000420176 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe4_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p12(gene name synonym)|uniprotkb:POLE4(gene name)|psi-mi:POLE4(display_short)|uniprotkb:DNA polymerase II subunit 4(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178762|imex:IM-17346-101 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_063949.2|ensembl:ENSG00000115350(gene)|ensembl:ENST00000483063(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ZtsQxDhQebNPEqYTb+G8yXvXp/49606 intact-crc:A76B1EB500ED4C83|rigid:r7WzXBkZaWHbWilgNwPBBq7mMPY false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q99704 intact:EBI-6248094 intact:EBI-1384360|uniprotkb:O43204|uniprotkb:Q53TY2|uniprotkb:Q9UHG6|ensembl:ENSP00000233668 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dok1_human(display_long)|uniprotkb:Downstream of tyrosine kinase 1(gene name synonym)|uniprotkb:"p62(dok)"(gene name synonym)|uniprotkb:pp62(gene name synonym)|uniprotkb:DOK1(gene name)|psi-mi:DOK1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178779|imex:IM-17346-102 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001184189.1|refseq:NP_001372.1|refseq:NP_001305797.1|ensembl:ENSG00000115325(gene)|ensembl:ENST00000233668(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002404(Insulin receptor substrate-1, PTB)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037751|mint:Q99704|rcsb pdb:2V76|reactome:R-HSA-8849469|reactome:R-HSA-8853659 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Pvjez+wIa3gWdY9ZYvWN6lmOM4o9606 intact-crc:6A05C02762BC2A91|rigid:7q6d1mXU3l3nDm/CiuPxtqRjpWE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:P32121 intact:EBI-6248094 intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178796|imex:IM-17346-103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606 intact-crc:8E05C6D6612E0DE2|rigid:ArsdHvsdBIqRcs3ryKvK5ej9H3Q false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9H8Y5 uniprotkb:Q9Q2G4 intact:EBI-724848|uniprotkb:Q9NVZ4|intact:EBI-28979360|ensembl:ENSP00000321617|ensembl:ENSP00000386337 intact:EBI-6248094 psi-mi:ankz1_human(display_long)|uniprotkb:Zinc finger protein 744(gene name synonym)|uniprotkb:ANKZF1(gene name)|psi-mi:ANKZF1(display_short)|uniprotkb:ZNF744(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178813|imex:IM-17346-104 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035869.1|refseq:NP_060559.2|ensembl:ENSP00000321617|ensembl:ENSP00000386337|ensembl:ENSG00000163516(gene)|ensembl:ENST00000323348(transcript)|ensembl:ENST00000410034(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|interpro:IPR002110(Ankyrin)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036770|interpro:IPR041175|interpro:IPR041540 go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:ddIMBu8TTSoqw3EFEPgqx+F0BHA9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:23D93198FE211AE3|rigid:sZzAeYSV4+6TAfTEy5AEwOD1JU0 false flag tag:c-c("MI:0518") mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04601 uniprotkb:O14734 intact:EBI-6164028|uniprotkb:O09780|uniprotkb:Q85587 intact:EBI-1237371|uniprotkb:O15261|uniprotkb:Q17RX4|ensembl:ENSP00000217455 psi-mi:nef_hv1h2(display_long)|uniprotkb:nef(gene name)|psi-mi:nef(display_short)|uniprotkb:3'ORF(gene name synonym)|uniprotkb:Negative factor(gene name synonym) psi-mi:acot8_human(display_long)|uniprotkb:ACOT8(gene name)|psi-mi:ACOT8(display_short)|uniprotkb:ACTEIII(gene name synonym)|uniprotkb:PTE1(gene name synonym)|uniprotkb:Choloyl-coenzyme A thioesterase(gene name synonym)|uniprotkb:Peroxisomal acyl-coenzyme A thioester hydrolase 1(gene name synonym)|uniprotkb:Peroxisomal long-chain acyl-CoA thioesterase 1(gene name synonym)|uniprotkb:HIV-Nef-associated acyl-CoA thioesterase(gene name synonym)|uniprotkb:Thioesterase II(gene name synonym)|uniprotkb:Peroxisomal acyl-CoA thioesterase 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178830|imex:IM-17346-105 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039504"(suppression by virus of host adaptive immune response)|go:"GO:0039505"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046776"(suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I)|interpro:IPR001558(HIV negative factor Nef)|interpro:IPR027480|rcsb pdb:3RL2|rcsb pdb:4NEE|rcsb pdb:4WU5|rcsb pdb:4WU7|rcsb pdb:5HGA|rcsb pdb:5HGB|rcsb pdb:5HGD|rcsb pdb:5HGH|rcsb pdb:7K80|interpro:IPR027481|rcsb pdb:7K81|refseq:NP_057857.2|dip:DIP-61724N|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-182218|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162599|reactome:R-HSA-164939|reactome:R-HSA-164940|reactome:R-HSA-164944|reactome:R-HSA-167590 refseq:NP_005460.2|dip:DIP-38179N|go:"GO:0036109"(alpha-linolenic acid metabolic process)|go:"GO:0043649"(dicarboxylic acid catabolic process)|go:"GO:0044466"(glutaryl-CoA hydrolase activity)|go:"GO:0045225"(negative regulation of CD4 production)|go:"GO:0047603"(acetoacetyl-CoA hydrolase activity)|go:"GO:0047617"(acyl-CoA hydrolase activity)|go:"GO:0047994"(hydroxymethylglutaryl-CoA hydrolase activity)|go:"GO:0052689"(carboxylic ester hydrolase activity)|go:"GO:0052815"(medium-chain acyl-CoA hydrolase activity)|go:"GO:0102991"(myristoyl-CoA hydrolase activity)|interpro:IPR003703(Acyl-CoA thioesterase)|interpro:IPR029069|interpro:IPR042171|reactome:R-HSA-193368|reactome:R-HSA-2046106|reactome:R-HSA-389887|reactome:R-HSA-390247|reactome:R-HSA-9033241|ensembl:ENSG00000101473(gene)|ensembl:ENST00000217455(transcript)|go:"GO:0003986"(acetyl-CoA hydrolase activity)|go:"GO:0004778"(succinyl-CoA hydrolase activity)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006637"(acyl-CoA metabolic process)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016289"(CoA hydrolase activity)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0033882"(choloyl-CoA hydrolase activity) psi-mi:"MI:0096"(pull down) - - figure legend:S11e|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:uiAB0f4u7Xkdeekvj0VexQZxR/Q11706 rogid:Q8Y3l4ysgKPMi3mJU2/g8mVxWE09606 intact-crc:1AEEDFCE9723A9FA|rigid:pqGZLh2NRrO7R/orsj9GgQXKzAo false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P31946 uniprotkb:Q76353 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 intact:EBI-6248077 psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:q76353_9hiv1(display_long) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178843|imex:IM-17346-106 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 intact-crc:B59930B5ED458D3E|rigid:LcMZEAM2gZ8MU7V0Ctzns3LWKRU false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7Z4H3 uniprotkb:Q76353 intact:EBI-6163836|ensembl:ENSP00000381220|uniprotkb:Q5TDQ4|uniprotkb:Q6NZ49|uniprotkb:Q9BTT2|uniprotkb:Q9BV31|uniprotkb:Q9Y3D1 intact:EBI-6248077 psi-mi:hddc2_human(display_long)|uniprotkb:CGI-130(orf name)|uniprotkb:HDDC2(gene name)|psi-mi:HDDC2(display_short)|uniprotkb:C6orf74(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 2(gene name synonym)|uniprotkb:NS5ATP2(gene name synonym)|uniprotkb:HD domain-containing protein 2(gene name synonym) psi-mi:q76353_9hiv1(display_long) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178857|imex:IM-17346-107 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR039356|rcsb pdb:4DMB|rcsb pdb:4L1J|rcsb pdb:4L7E|rcsb pdb:4L7W|ensembl:ENSG00000111906(gene)|ensembl:ENST00000398153(transcript)|go:"GO:0002953"(5'-deoxynucleotidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0046872"(metal ion binding)|refseq:NP_057147.2 go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:8f3lTUUoG5pAau6LGaxmi1qS6lU9606 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 intact-crc:F5F0E34C64D4D0A3|rigid:ErSF7jwTe1JIy48bmDVM9d7i3oE false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9H4L5 intact:EBI-6248094 intact:EBI-1051317|uniprotkb:O14591|uniprotkb:O43357|uniprotkb:O43358|uniprotkb:Q8N702|uniprotkb:Q8N703|uniprotkb:Q8N704|uniprotkb:Q8NFH0|uniprotkb:Q8NFH1|uniprotkb:Q8NI12|uniprotkb:Q8NI13|uniprotkb:Q9BZF4|uniprotkb:Q9UED6|uniprotkb:B8ZZ79|uniprotkb:B8ZZP0|uniprotkb:A4D167|uniprotkb:A4D168|uniprotkb:A4D169|uniprotkb:A4D170|uniprotkb:A4D171|uniprotkb:A4D172|intact:EBI-28979334|ensembl:ENSP00000315410 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl3_human(display_long)|uniprotkb:OSBPL3(gene name)|psi-mi:OSBPL3(display_short)|uniprotkb:KIAA0704(gene name synonym)|uniprotkb:ORP3(gene name synonym)|uniprotkb:OSBP3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178871|imex:IM-17346-108 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056365.1|refseq:NP_663160.1|refseq:NP_663161.1|refseq:NP_663162.1|refseq:XP_011513560.1|ensembl:ENSP00000315410|ensembl:ENST00000396429|ensembl:ENSP00000379706|ensembl:ENST00000396431|ensembl:ENSP00000379708|ensembl:ENST00000409069|ensembl:ENSP00000386953|ensembl:ENST00000409452|ensembl:ENSP00000386801|ensembl:ENST00000409555|ensembl:ENSP00000386990|ensembl:ENST00000409759|ensembl:ENSP00000386325|ensembl:ENST00000409863|ensembl:ENSP00000386429|refseq:XP_005249755.1|refseq:XP_006715744.1|refseq:XP_006715745.1|refseq:XP_006715746.1|ensembl:ENSG00000070882(gene)|ensembl:ENST00000313367(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9H4L5|rcsb pdb:7CYZ|rcsb pdb:7DEI|rcsb pdb:7DEJ|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:kiT2v1pGFlF+1s8wGhNidJyRbYc9606 intact-crc:AB4253B8525718DA|rigid:Uhy9PZAvTDa2mqQJa4yX2K80hSI false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q76353 uniprotkb:Q9H583 intact:EBI-6248077 intact:EBI-1048716|uniprotkb:Q5T3Q8|uniprotkb:Q6P197|uniprotkb:Q9NW23|ensembl:ENSP00000355541 psi-mi:q76353_9hiv1(display_long) psi-mi:heat1_human(display_long)|uniprotkb:Protein BAP28(gene name synonym)|uniprotkb:HEATR1(gene name)|psi-mi:HEATR1(display_short)|uniprotkb:BAP28(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 10 homolog(gene name synonym)|uniprotkb:UTP10(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178888|imex:IM-17346-109 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_060542.4|ensembl:ENSG00000119285(gene)|ensembl:ENST00000366582(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0016020"(membrane)|go:"GO:0030515"(snoRNA binding)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034455"(t-UTP complex)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012954(BP28, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR022125|interpro:IPR040191|mint:Q9H583|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:0WoP84UUVfXWppmvCYa/n5GTzc89606 intact-crc:F2549AD4A362E84B|rigid:ur7I/V9CRtBiBQBksCET6Gnave4 false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q76353 uniprotkb:Q14566 intact:EBI-6248077 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:q76353_9hiv1(display_long) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178902|imex:IM-17346-110 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:B23E266670AC4FAF|rigid:fEXUNoAXvQOe0dLWV5Wq030CBEQ false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q76353 uniprotkb:P13667 intact:EBI-6248077 intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129 psi-mi:q76353_9hiv1(display_long) psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178916|imex:IM-17346-111 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606 intact-crc:236F1C138985EA71|rigid:cSlrlBOgH4VFCUXM+bZnOCS330A false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q76353 uniprotkb:Q9Y263 intact:EBI-6248077 intact:EBI-1994037|uniprotkb:Q53EU5|uniprotkb:Q5VY33|uniprotkb:Q9NUL8|uniprotkb:Q9NVE9|uniprotkb:Q9UF53|uniprotkb:Q9Y5L1|ensembl:ENSP00000380460 psi-mi:q76353_9hiv1(display_long) psi-mi:plap_human(display_long)|uniprotkb:PLAA(gene name)|psi-mi:PLAA(display_short)|uniprotkb:PLAP(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178930|imex:IM-17346-112 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_001026859.1|ensembl:ENSG00000137055(gene)|ensembl:ENST00000397292(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016236"(macroautophagy)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0045202"(synapse)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001680(WD40 repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013535(PUL)|interpro:IPR015155("PFU (PLAA family ubiquitin binding)")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR036322|interpro:IPR038122|mint:Q9Y263|rcsb pdb:2K89|rcsb pdb:2K8A|rcsb pdb:2K8B|rcsb pdb:2K8C|rcsb pdb:3EBB psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:SoClA00UzZpX9vV1cJWvefY6eY89606 intact-crc:C6FA201E262F5813|rigid:ORTUPnqM2MIaeSdvlPLyjrgTVyo false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q76353 uniprotkb:O60518 intact:EBI-6248077 intact:EBI-1055771|uniprotkb:Q5T7X4|uniprotkb:Q7Z3V2|uniprotkb:Q96E78|ensembl:ENSP00000259569 psi-mi:q76353_9hiv1(display_long) psi-mi:rnbp6_human(display_long)|uniprotkb:RANBP6(gene name)|psi-mi:RANBP6(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178944|imex:IM-17346-113 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS refseq:NP_036548.1|refseq:NP_001230131.1|refseq:NP_001230132.1|ensembl:ENSG00000137040(gene)|ensembl:ENST00000259569(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|interpro:IPR041389|interpro:IPR041653|mint:O60518 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 rogid:3yh3vq2Bj+aqE9zWUU9LET7en6g9606 intact-crc:AF007EB7B8C83E2E|rigid:+cc4PZYzOd2rhIniEc5lCRTrKd0 false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P22314 uniprotkb:Q76353 intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568 intact:EBI-6248077 psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym) psi-mi:q76353_9hiv1(display_long) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178958|imex:IM-17346-114 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168 go:"GO:0003676"(nucleic acid binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015074"(DNA integration)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0046718"(viral entry into host cell)|rcsb pdb:6L0C|interpro:IPR001037(Integrase, C-terminal, retroviral)|interpro:IPR001584(Integrase, catalytic core)|interpro:IPR017856(Integrase, N-terminal zinc-binding domain-like)|interpro:IPR003308(Integrase, N-terminal zinc-binding domain)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR036862|rcsb pdb:6VQS psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11b|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606 rogid:BCopeG10uQbkzoPkz/AccRsNPSo11676 intact-crc:1814E77625BE4970|rigid:71VLuG+SxwLgLnMtYfNWMsrkfUA false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9NRF9 intact:EBI-6248094 intact:EBI-744901|uniprotkb:Q5W0U1|uniprotkb:Q8N758|uniprotkb:Q8NCE5|uniprotkb:Q9NR32|ensembl:ENSP00000363284|ensembl:ENSP00000363286 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:dpoe3_human(display_long)|uniprotkb:DNA polymerase epsilon subunit p17(gene name synonym)|uniprotkb:Chromatin accessibility complex 17 kDa protein(gene name synonym)|uniprotkb:Arsenic-transactivated protein(gene name synonym)|uniprotkb:POLE3(gene name)|psi-mi:POLE3(display_short)|uniprotkb:CHRAC17(gene name synonym)|uniprotkb:DNA polymerase II subunit 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178972|imex:IM-17346-115 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001265184.1|refseq:NP_059139.3|ensembl:ENSG00000148229(gene)|ensembl:ENST00000374169(transcript)|ensembl:ENST00000374171(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008622"(epsilon DNA polymerase complex)|go:"GO:0008623"(CHRAC)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0042766"(nucleosome mobilization)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003958(Transcription factor CBF/NF-Y/archaeal histone)|interpro:IPR009072(Histone-fold)|reactome:R-HSA-110314|reactome:R-HSA-5651801|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-68952|reactome:R-HSA-68962 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:eTI1XsrypxKqml09tm4GAImoZgI9606 intact-crc:386BA85CB0EC9680|rigid:3uKdv7wML4i+z+BCzJzTgscLugw false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q13501 uniprotkb:P12504 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 intact:EBI-779991 psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6178989|imex:IM-17346-116 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:9426F34DA9821C1A|rigid:oi+Fw9kdBArSV2Suv5QVjwxJaks false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P33991 uniprotkb:Q9Q2G4 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 intact:EBI-6248094 psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179002|imex:IM-17346-117 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:6D74BDB0B4370558|rigid:Qf61d9xkkpyOvUnZEShrqhf5GTA false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q13617 intact:EBI-779991 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179019|imex:IM-17346-118 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:3C1DB99EA6F2B3C4|rigid:/YU98Bqtp0WGrnzvdNteyZIaoUY false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q93034 uniprotkb:P12504 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-779991 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179032|imex:IM-17346-119 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:B962E9986C186BAB|rigid:nnlvZ57nZWdTP9mH/K6YSS0keyk false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99615 uniprotkb:P12504 intact:EBI-357552|ensembl:ENSP00000406463|uniprotkb:Q7Z784 intact:EBI-779991 psi-mi:dnjc7_human(display_long)|uniprotkb:DNAJC7(gene name)|psi-mi:DNAJC7(display_short)|uniprotkb:TPR2(gene name synonym)|uniprotkb:TTC2(gene name synonym)|uniprotkb:Tetratricopeptide repeat protein 2(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179045|imex:IM-17346-120 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168259(gene)|ensembl:ENST00000457167(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR036869|reactome:R-HSA-3371453|refseq:NP_003306.3|refseq:XP_011523469.1|refseq:XP_011523470.1|refseq:XP_011523471.1|refseq:NP_001138238.1|refseq:XP_016880483.1 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:eZ1/nlVA9bOU/N3yrJ3pWrnM1P09606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:C8DC3922FBE2EC36|rigid:FPG+cngp3+2m9j1a8gvqVri1dXE false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q15370 intact:EBI-779991 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179058|imex:IM-17346-121 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:9ADB5D3C6E67A7E4|rigid:IiB6KavfUk+pDqKUpjj84lqsijA false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q15369 intact:EBI-779991 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179071|imex:IM-17346-122 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:4D7C611A4FD031C7|rigid:QIoZqkf6Mdf2samkbqrQc8jULMs false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q13227 intact:EBI-779991 intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179084|imex:IM-17346-123 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606 intact-crc:9DD82D4D51285EF3|rigid:GX22LgvaGHpGlJDn62oPFw44sYk false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O15379 uniprotkb:P12504 intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967 intact:EBI-779991 psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179097|imex:IM-17346-124 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:X5pnE98s15eXKev3nauN7ri5kqg9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:ACBB5F3918ADED9E|rigid:NueU16Zug1ani2d4eioMuE9oNqU false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q16659 uniprotkb:P12504 intact:EBI-1384105|uniprotkb:Q68DH4|uniprotkb:Q8IYN8|uniprotkb:B2R945|uniprotkb:B5BU65|ensembl:ENSP00000261845|ensembl:ENSP00000505601|ensembl:ENSP00000505862|ensembl:ENSP00000506036|ensembl:ENSP00000506184 intact:EBI-779991 psi-mi:mk06_human(display_long)|uniprotkb:ERK3(gene name synonym)|uniprotkb:PRKM6(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 3(gene name synonym)|uniprotkb:MAP kinase isoform p97(gene name synonym)|uniprotkb:MAPK6(gene name)|psi-mi:MAPK6(display_short) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179110|imex:IM-17346-125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011520084.1|refseq:NP_002739.1|refseq:XP_005254594.1|refseq:XP_005254595.1|refseq:XP_005254596.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0032156"(septin cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|ensembl:ENSG00000069956(gene)|ensembl:ENST00000261845(transcript)|ensembl:ENST00000680066(transcript)|ensembl:ENST00000680652(transcript)|ensembl:ENST00000680777(transcript)|ensembl:ENST00000681888(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008350(ERK3/4 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:6YKY|rcsb pdb:6YLC|rcsb pdb:6YLL|rcsb pdb:7AQB|reactome:R-HSA-5687128 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:Gek79ujQv6Xznswv4ZIxXbgX4OE9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:84EFCF26F69DA9C2|rigid:XtKX0wsRWmAixzI7l+8CsYZu22U false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q13951 uniprotkb:P12504 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 intact:EBI-779991 psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179123|imex:IM-17346-126 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:C6684E39B1ED2B42|rigid:ML5R23gv0XqdTDZ/MNNiL18dYio false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:P51784 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179136|imex:IM-17346-127 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:3EE4BC9E0FACF696|rigid:ly6P6C1QzB7zSDk2/663NQzBGRI false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UBF6 uniprotkb:P12504 intact:EBI-398632|uniprotkb:Q9BXN8|uniprotkb:Q9Y5M7|uniprotkb:A8MTB5|uniprotkb:A8K1H9|uniprotkb:D3DNF7|uniprotkb:D3DNF8|uniprotkb:C9JYL3|ensembl:ENSP00000273480 intact:EBI-779991 psi-mi:rbx2_human(display_long)|uniprotkb:RNF7(gene name)|psi-mi:RNF7(display_short)|uniprotkb:RBX2(gene name synonym)|uniprotkb:ROC2(gene name synonym)|uniprotkb:SAG(gene name synonym)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Regulator of cullins 2(gene name synonym)|uniprotkb:CKII beta-binding protein 1(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179149|imex:IM-17346-128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055060.1|refseq:NP_899060.1|refseq:NP_001188299.1|ensembl:ENSG00000114125(gene)|ensembl:ENST00000273480(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045116"(protein neddylation)|go:"GO:0051775"(response to redox state)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|rcsb pdb:2ECL|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:FNop0ozErv05khKc5si7nNH/Hww9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:D80EAF98867A5654|rigid:tvSUnauGOylx36PtwhTnbshzOKc false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:Q96EB6 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179162|imex:IM-17346-129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 intact-crc:ECF1264FB7053F66|rigid:zQgx9XeBiPosMAnJUvaedjFvYjU false tandem tag:c-c("MI:0677") flag tag:n-n("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UNE7 uniprotkb:P12504 intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548 intact:EBI-779991 psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179175|imex:IM-17346-130 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:h4QyIM0TptgkQppPUgiKn68XjP49606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:B09E5D0CB873212A|rigid:p2dxzuwugAxcEDKRnziOqGI9zMQ false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:P11441 intact:EBI-779991 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179188|imex:IM-17346-131 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 intact-crc:4A118B9F10EEBAB0|rigid:uAyx1jRMa8Fdb9PnoLkpK/2UCZE false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q8IWV8 intact:EBI-779991 intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179201|imex:IM-17346-132 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168 psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606 intact-crc:685C83AFAB95C762|rigid:1fftdghhjhruvwv4LxNp/InmKiI false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q8TEB1 intact:EBI-779991 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179214|imex:IM-17346-133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:80A4FF57FDF85F65|rigid:Jm2KkjlJhdr9ZbA0+vUW16Xghto false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:Q5SW79 intact:EBI-6164519 intact:EBI-1104799|uniprotkb:O75058|uniprotkb:Q5SW77|uniprotkb:Q5SW78|uniprotkb:Q7LGA9|uniprotkb:Q86W31|uniprotkb:Q9UQ08|uniprotkb:Q9UQ09|intact:EBI-2559293|intact:EBI-2554822|ensembl:ENSP00000355500|ensembl:ENSP00000483344 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:ce170_human(display_long)|uniprotkb:CEP170(gene name)|psi-mi:CEP170(display_short)|uniprotkb:FAM68A(gene name synonym)|uniprotkb:KAB(gene name synonym)|uniprotkb:KIAA0470(gene name synonym)|uniprotkb:KARP-1-binding protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179227|imex:IM-17346-134 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001035863.1|refseq:NP_001035864.1|refseq:NP_055627.2|ensembl:ENSG00000143702(gene)|ensembl:ENSG00000276725(gene)|ensembl:ENST00000366542(transcript)|ensembl:ENST00000612450(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR026644|interpro:IPR029300|mint:Q5SW79|rcsb pdb:4JON|refseq:XP_016858425.1|dip:DIP-37594N psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:gEJsUZqeO9zpm94iMzIAUvsUbqc9606 intact-crc:026125402687ED89|rigid:UmZD9Thf9tx950C9A6xQLSiJbXI false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:Q8WXD5 intact:EBI-6164519 intact:EBI-752301|uniprotkb:Q53SI5|uniprotkb:Q8WVB4|uniprotkb:Q9H5G6|uniprotkb:B2RDP8|ensembl:ENSP00000281950 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:gemi6_human(display_long)|uniprotkb:SIP2(gene name synonym)|uniprotkb:GEMIN6(gene name)|psi-mi:GEMIN6(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179240|imex:IM-17346-135 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_079051.9|dip:DIP-41331N|ensembl:ENSG00000152147(gene)|ensembl:ENST00000281950(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016604"(nuclear body)|go:"GO:0032797"(SMN complex)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR009422(Gemin6)|mint:Q8WXD5|rcsb pdb:1Y96|rcsb pdb:7BBL|reactome:R-HSA-191859 psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:AaQyOsKgOMpkny7dYKmgwu0/c1g9606 intact-crc:7E9D39BE6CCF4ED9|rigid:mwW+LhG4omxtCzcT/5o3+gTkZgg false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:Q9H4A6 intact:EBI-6164519 intact:EBI-2465479|uniprotkb:Q9UIW5|ensembl:ENSP00000265070 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:golp3_human(display_long)|uniprotkb:GOLPH3(gene name)|psi-mi:GOLPH3(display_short)|uniprotkb:GPP34(gene name synonym)|uniprotkb:Coat protein GPP34(gene name synonym)|uniprotkb:Mitochondrial DNA absence factor(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179253|imex:IM-17346-136 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_071413.1|ensembl:ENSG00000113384(gene)|ensembl:ENST00000265070(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007030"(Golgi organization)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0009306"(protein secretion)|go:"GO:0010467"(gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045053"(protein retention in Golgi apparatus)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0060352"(cell adhesion molecule production)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072752"(cellular response to rapamycin)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|interpro:IPR008628(Golgi phosphoprotein 3)|interpro:IPR038261|mint:Q9H4A6|rcsb pdb:3KN1 psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:tHHREhHksCP+Yf9FzycM9cI+wkc9606 intact-crc:A3AD179E8BB1A8DA|rigid:yDR0FNXLtUxnuew7pSyk3JznZ4k false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:O14929 intact:EBI-6164519 intact:EBI-2339359|uniprotkb:Q53SU4|uniprotkb:Q53QF0|uniprotkb:Q49A44|uniprotkb:Q6P594|uniprotkb:Q8WWB9|ensembl:ENSP00000264108 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:hat1_human(display_long)|uniprotkb:HAT1(gene name)|psi-mi:HAT1(display_short)|uniprotkb:KAT1(gene name synonym)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179266|imex:IM-17346-137 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_003633.1|dip:DIP-52811N|ensembl:ENSG00000128708(gene)|ensembl:ENST00000264108(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006323"(DNA packaging)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0007584"(response to nutrient)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|mint:O14929|rcsb pdb:2P0W|rcsb pdb:6VO5|reactome:R-HSA-3214847 psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:80KgRaid3NeRfAUdTHMQ/r0VuGo9606 intact-crc:32959C77B5B6EC1B|rigid:Qu7VUCb96Z65nqgMPUXpgTppw1Q false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:O75386 intact:EBI-6164519 intact:EBI-5357290|uniprotkb:B3KNB7|uniprotkb:D3DUQ4|uniprotkb:Q8N5B0|uniprotkb:B7Z6A2|uniprotkb:F8WBZ9|intact:EBI-28988689|ensembl:ENSP00000410051 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:tulp3_human(display_long)|uniprotkb:TULP3(gene name)|psi-mi:TULP3(display_short)|uniprotkb:TUBL3(gene name synonym)|uniprotkb:Tubby-like protein 3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179279|imex:IM-17346-138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001153880.1|refseq:NP_003315.2|ensembl:ENST00000397132|ensembl:ENSP00000380321|ensembl:ENSP00000410051|ensembl:ENST00000540184|ensembl:ENSP00000444110|ensembl:ENSG00000078246(gene)|ensembl:ENST00000448120(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0019899"(enzyme binding)|go:"GO:0021914"(negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060348"(bone development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060831"(smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061548"(ganglion development)|go:"GO:0097546"(ciliary base)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:0120160"(intraciliary transport particle A binding)|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|interpro:IPR000007(Tubby, C-terminal)|interpro:IPR005398(Tubby, N-terminal)|interpro:IPR018066|interpro:IPR025659|reactome:R-HSA-5610787 psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:zfk5c5/u3lyjIQfvJWtmZeee0SI9606 intact-crc:70BE357E03D1CAC6|rigid:yglY4AuUZiwFmLjj+VwwQh36oGk false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:Q9Y4B6 intact:EBI-6164519 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179292|imex:IM-17346-139 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:09B137B941D7B410|rigid:fbC1zvXUZx+2HG20qH75hgJX8MM false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P61289 uniprotkb:P12504 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 intact:EBI-779991 psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179305|imex:IM-17346-140 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 intact-crc:86E2DEA7414F80F0|rigid:y/yKmepYfbK+Kvo3TmDSGt/suIo false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04618 uniprotkb:Q04837 intact:EBI-6164309 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179318|imex:IM-17346-141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201 psi-mi:"MI:0096"(pull down) - - figure legend:S11g|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 intact-crc:EA5D18837AE291F8|rigid:Z9lRXc8KwcjP1urKLuc5+3XSTiM false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12520 uniprotkb:Q5TAQ9 intact:EBI-6164519 intact:EBI-740686|uniprotkb:Q12839|uniprotkb:Q4QQI6|uniprotkb:Q53F14|uniprotkb:Q66K50|uniprotkb:Q68CS7|uniprotkb:Q96E00|intact:EBI-2559125|uniprotkb:D3DVE6|ensembl:ENSP00000318227|ensembl:ENSP00000357052|ensembl:ENSP00000357053 psi-mi:vpr_hv1n5(display_long)|uniprotkb:vpr(gene name)|psi-mi:vpr(display_short)|uniprotkb:R ORF protein(gene name synonym)|uniprotkb:Viral protein R(gene name synonym) psi-mi:dcaf8_human(display_long)|uniprotkb:DCAF8(gene name)|psi-mi:DCAF8(display_short)|uniprotkb:H326(gene name synonym)|uniprotkb:WDR42A(gene name synonym)|uniprotkb:WD repeat-containing protein 42A(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179334|imex:IM-17346-142 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006811"(ion transport)|go:"GO:0007049"(cell cycle)|go:"GO:0019051"(induction by virus of host apoptotic process)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0042025"(host cell nucleus)|go:"GO:0043655"(host extracellular space)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000012(Retroviral VpR/VpX protein)|rcsb pdb:1BDE|rcsb pdb:1DSJ|rcsb pdb:1DSK|rcsb pdb:1KZS|rcsb pdb:1KZT|rcsb pdb:1KZV|rcsb pdb:5JK7 refseq:NP_056541.2|ensembl:ENSG00000132716(gene)|ensembl:ENST00000326837(transcript)|ensembl:ENST00000368073(transcript)|ensembl:ENST00000368074(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q5TAQ9|rcsb pdb:3I8E|reactome:R-HSA-8951664|dip:DIP-48762N psi-mi:"MI:0096"(pull down) - - figure legend:S11d|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:cxA2Zi9LWY3zUfouwbNOO4n99QI11698 rogid:6Bbv6KwtHrJ0W4mcIronVPj4bTA9606 intact-crc:63980C0A95CD86B8|rigid:yIywsgg3Uks+/OsIItoTD/olnrc false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9BZF3 intact:EBI-6248094 intact:EBI-2372709|uniprotkb:B4DTW1|uniprotkb:Q4ZG68|uniprotkb:Q53T68|uniprotkb:Q59H61|uniprotkb:Q7Z4Q1|uniprotkb:Q8N9T0|uniprotkb:Q96SR1|uniprotkb:C4AME4|uniprotkb:C4AMC0|uniprotkb:D3DPF6|uniprotkb:D3DPF7|uniprotkb:Q86V84|intact:EBI-28980578|ensembl:ENSP00000190611 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:osbl6_human(display_long)|uniprotkb:OSBPL6(gene name)|psi-mi:OSBPL6(display_short)|uniprotkb:ORP6(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179347|imex:IM-17346-143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001188409.1|refseq:NP_001188410.1|refseq:NP_001188411.1|refseq:NP_115912.1|refseq:NP_665682.1|ensembl:ENSP00000190611|ensembl:ENST00000315022|ensembl:ENSP00000318723|ensembl:ENST00000357080|ensembl:ENSP00000349591|ensembl:ENST00000359685|ensembl:ENSP00000352713|ensembl:ENST00000392505|ensembl:ENSP00000376293|ensembl:ENST00000409045|ensembl:ENSP00000387248|ensembl:ENST00000409631|ensembl:ENSP00000386885|refseq:XP_016858755.1|refseq:XP_016858756.1|refseq:XP_016858759.1|refseq:XP_016858760.1|ensembl:ENSG00000079156(gene)|ensembl:ENST00000190611(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|mint:Q9BZF3|reactome:R-HSA-192105 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:fOUP23b3kO1lBSBPNHP6Ghe6i8c9606 intact-crc:0E00C03705CEEA2C|rigid:ALBg+S0idYToLFb/I81V6gi+1UQ false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9UKK3 uniprotkb:Q9Q2G4 intact:EBI-2623021|uniprotkb:Q5QNZ9|uniprotkb:O75903|uniprotkb:Q14682|uniprotkb:Q9H1M6|ensembl:ENSP00000371419 intact:EBI-6248094 psi-mi:parp4_human(display_long)|uniprotkb:ADPRTL1(gene name synonym)|uniprotkb:KIAA0177(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:193 kDa vault protein(gene name synonym)|uniprotkb:PARP-related/IalphaI-related H5/proline-rich(gene name synonym)|uniprotkb:"Vault poly(ADP-ribose) polymerase"(gene name synonym)|uniprotkb:PARP4(gene name)|psi-mi:PARP4(display_short)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 4(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 4(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179364|imex:IM-17346-144 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011533234.1|refseq:NP_006428.2|ensembl:ENSG00000102699(gene)|ensembl:ENST00000381989(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006281"(DNA repair)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008219"(cell death)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0042493"|go:"GO:0051972"(regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001357(BRCT)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013694(Vault protein inter-alpha-trypsin)|interpro:IPR031273|interpro:IPR036420|interpro:IPR036465|interpro:IPR036616|mint:Q9UKK3|reactome:R-HSA-197264|reactome:R-HSA-9683610|reactome:R-HSA-9694631 go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:d1n+oei4ZSmqUnvJzMe6RLq2XOc9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:EFD5DA2B897B1015|rigid:aCCcGNQ1blZzixjnhyhE7M1p1DQ false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P61758 uniprotkb:Q9Q2G4 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 intact:EBI-6248094 psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179381|imex:IM-17346-145 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1 go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2019/04/15 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:D76D97A2E40382E1|rigid:R5FC5KYIo6OeoZbsock4v8mJ2oU false flag tag:c-c("MI:0518") tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q8TB72 intact:EBI-6248094 intact:EBI-311190|uniprotkb:O00234|uniprotkb:Q53TV7|uniprotkb:Q8WY43|uniprotkb:Q9HAN2|uniprotkb:B4E2B6|uniprotkb:B3KSL0|uniprotkb:D6W527 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:pum2_human(display_long)|uniprotkb:PUM2(gene name)|psi-mi:PUM2(display_short)|uniprotkb:KIAA0235(gene name synonym)|uniprotkb:PUMH2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179398|imex:IM-17346-146 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_056132.1|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR001313(Pumilio RNA-binding region)|rcsb pdb:3Q0Q|rcsb pdb:3Q0R|rcsb pdb:3Q0S|refseq:NP_001269681.1|interpro:IPR033133|refseq:XP_011531021.1|refseq:XP_011531022.1|refseq:XP_011531023.1|refseq:XP_005262664.1|refseq:XP_005262666.1|refseq:XP_006712036.1|refseq:XP_006712037.1|interpro:IPR033712|refseq:XP_016859190.1|refseq:XP_016859191.1|refseq:XP_016859196.1|refseq:XP_016859197.1|reactome:R-HSA-8951664|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034063"(stress granule assembly)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035198"(miRNA binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:0051983"(regulation of chromosome segregation) psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:WOut5XivMQAQkHVKu1wjFTK6ePM9606 intact-crc:B13B882B6F4318AE|rigid:Z2n+Mk2w+LRfq6RdDlg7dMPvXSE false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q12874 uniprotkb:Q9Q2G4 intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110 intact:EBI-6248094 psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym) psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179415|imex:IM-17346-147 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 psi-mi:"MI:0096"(pull down) - comment:Extra met in N-terminal figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:fNjNguUOXqApr46rOAEpTs2geqY9606 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 intact-crc:5667456DC1B9B567|rigid:w+VSmilC8K/6VDF0DkPZajN6dJI false flag tag:c-c("MI:0518") mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:O60232 intact:EBI-6248094 intact:EBI-741415|ensembl:ENSP00000312318 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:znrd2_human(display_long)|uniprotkb:ZNRD2(gene name)|psi-mi:ZNRD2(display_short)|uniprotkb:Autoantigen p27(gene name synonym)|uniprotkb:SSSCA1(gene name synonym)|uniprotkb:Sjoegren syndrome/scleroderma autoantigen 1(gene name synonym)|uniprotkb:Zinc ribbon domain-containing protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179432|imex:IM-17346-148 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_006387.1|ensembl:ENSG00000173465(gene)|ensembl:ENST00000309328(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0051301"(cell division)|interpro:IPR009563(Sjogrens syndrome scleroderma autoantigen 1)|rcsb pdb:6HCZ psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:Uou80pZneoL39/0YYzb1TAbiB2I9606 intact-crc:64DFB8F1B2CDE295|rigid:gtzmLEWj+/B/WY91UePLmAkBgHQ false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9UHF7 intact:EBI-6248094 intact:EBI-2556151|uniprotkb:Q9UHH6|uniprotkb:Q9NWE1|uniprotkb:Q08AU2|uniprotkb:B4E1Z5|ensembl:ENSP00000220888|ensembl:ENSP00000492037 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:trps1_human(display_long)|uniprotkb:Tricho-rhino-phalangeal syndrome type I protein(gene name synonym)|uniprotkb:Zinc finger protein GC79(gene name synonym)|uniprotkb:TRPS1(gene name)|psi-mi:TRPS1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179449|imex:IM-17346-149 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_054831.2|refseq:NP_001269831.1|refseq:XP_011515566.1|refseq:XP_011515568.1|refseq:XP_011515570.1|refseq:NP_001269832.1|refseq:XP_006716688.1|refseq:NP_001317528.1|ensembl:ENSG00000104447(gene)|ensembl:ENST00000220888(transcript)|ensembl:ENST00000640765(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0032991"(protein-containing complex)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR028440|interpro:IPR036236 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:M9Qu8GLaQiBGt4rWs+NuYJas8fs9606 intact-crc:AD467941AA9D68DE|rigid:qb0VVph3C1xgv/0MVBJyWpWtQOU false mutation:25-25("MI:0118")|tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04618 uniprotkb:Q96BP2 intact:EBI-6164309 intact:EBI-5454898|ensembl:ENSP00000361923 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:chch1_human(display_long)|uniprotkb:CHCHD1(gene name)|psi-mi:CHCHD1(display_short)|uniprotkb:C10orf34(gene name synonym)|uniprotkb:Nuclear protein C2360(gene name synonym)|uniprotkb:28S ribosomal protein S37, mitochondrial(gene name synonym)|uniprotkb:MRPS37(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS37(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179466|imex:IM-17346-150 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_976043.1|ensembl:ENSG00000172586(gene)|ensembl:ENST00000372833(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR009069(MTCP1)|interpro:IPR010625(CHCH)|interpro:IPR033620|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0096"(pull down) - - figure legend:S11g|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:NrXh0XQ/wnElrxTM/KjipjA6WYY9606 intact-crc:29DC5979282A20EC|rigid:quBE1N4jF86Lji/HqOlY4p2zHTs false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04618 uniprotkb:Q8WV92 intact:EBI-6164309 intact:EBI-2691489|uniprotkb:Q69YV0|ensembl:ENSP00000289359 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:mitd1_human(display_long)|uniprotkb:MITD1(gene name)|psi-mi:MITD1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179482|imex:IM-17346-151 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_620153.1|refseq:NP_001307346.1|refseq:NP_001307347.1|refseq:NP_001307348.1|ensembl:ENSG00000158411(gene)|ensembl:ENST00000289359(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|interpro:IPR007330(MIT)|interpro:IPR032341|interpro:IPR036181|interpro:IPR038113|rcsb pdb:2YMB|rcsb pdb:4A5X|rcsb pdb:4A5Z psi-mi:"MI:0096"(pull down) - - figure legend:S11g|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:VY5MeLAmoWXB0gKSJR3d9OhT1Vk9606 intact-crc:999CA5AABDD30551|rigid:2UhgkdjTykIoNecksZ7qogRKlgk false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P12504 uniprotkb:Q9C0C7 intact:EBI-779991 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179498|imex:IM-17346-152 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N psi-mi:"MI:0096"(pull down) - - figure legend:S11c|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:23282F33822FE512|rigid:RbX5Gry9B33ulO6QiwBKGpCJ7Ig false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04618 uniprotkb:P82933 intact:EBI-6164309 intact:EBI-721385|intact:EBI-1049991|uniprotkb:Q6PG40|ensembl:ENSP00000258455 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:rt09_human(display_long)|uniprotkb:MRPS9(gene name)|psi-mi:MRPS9(display_short)|uniprotkb:RPMS9(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein uS9m(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179511|imex:IM-17346-153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 refseq:NP_872578.1|ensembl:ENSG00000135972(gene)|ensembl:ENST00000258455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P82933|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6ZSE psi-mi:"MI:0096"(pull down) - - figure legend:S11g|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:XNB4GL84eYgYFEB3WxOtoD3Ub989606 intact-crc:40FE85CC97A723C6|rigid:XB90zAI1FDpJPwHq/7LBc8di/Y4 false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Q2G4 uniprotkb:Q9UMS0 intact:EBI-6248094 intact:EBI-725252|uniprotkb:Q53QE5|uniprotkb:Q6VNZ8|uniprotkb:Q7Z5B1|uniprotkb:Q7Z5B2|uniprotkb:Q9Y322|uniprotkb:B4DUL9|ensembl:ENSP00000387219 psi-mi:q9q2g4_9hiv1(display_long)|uniprotkb:ORF(gene name)|psi-mi:ORF(display_short)|uniprotkb:Retropepsin(gene name synonym) psi-mi:nfu1_human(display_long)|uniprotkb:HIRA-interacting protein 5(gene name synonym)|uniprotkb:NFU1(gene name)|psi-mi:NFU1(display_short)|uniprotkb:CGI-33(orf name)|uniprotkb:HIRIP5(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179527|imex:IM-17346-154 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004190"(aspartic-type endopeptidase activity)|interpro:IPR018061|interpro:IPR001995(Peptidase A2A, retrovirus, catalytic)|interpro:IPR021109|interpro:IPR001969(Peptidase aspartic, active site)|interpro:IPR034170 refseq:NP_001002755.1|refseq:NP_056515.2|refseq:NP_001002756.1|ensembl:ENSG00000169599(gene)|ensembl:ENST00000410022(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|interpro:IPR001075(NIF system FeS cluster assembly, NifU, C-terminal)|interpro:IPR014824(NIF system FeS cluster assembly, NifU-like scaffold, N-terminal)|interpro:IPR034904|interpro:IPR036498|rcsb pdb:2LTM|rcsb pdb:2M5O|refseq:XP_016859297.1 psi-mi:"MI:0096"(pull down) comment:Extra met in N-terminal - figure legend:S11a|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:GeuXqJCxiRep5pdAi64PQu1vh2w11676 rogid:ilyUYSw8tpfn8DDWGsj96O6f7jk9606 intact-crc:CFDA57C20689A801|rigid:sxATXiryVVm0VcNUVVkpBOAVSs0 false tandem tag:c-c("MI:0677")|mutation:25-25("MI:0118") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:P51825 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2610180|ensembl:ENSP00000305689|intact:EBI-28974592|uniprotkb:B4DTU1|uniprotkb:E9PBM3|intact:EBI-11028221 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff1_human(display_long)|uniprotkb:AFF1(gene name)|psi-mi:AFF1(display_short)|uniprotkb:AF4(gene name synonym)|uniprotkb:FEL(gene name synonym)|uniprotkb:MLLT2(gene name synonym)|uniprotkb:PBM1(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 4 protein(gene name synonym)|uniprotkb:Proto-oncogene AF4(gene name synonym)|uniprotkb:Protein FEL(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179544|imex:IM-17346-155 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF ensembl:ENSP00000305689|ensembl:ENST00000395146|ensembl:ENSP00000378578|ensembl:ENST00000544085|ensembl:ENSP00000440843|refseq:NP_001160165.1|refseq:XP_011530275.1|refseq:NP_005926.1|refseq:XP_005263064.1|refseq:NP_001300888.1|refseq:NP_001300889.1|ensembl:ENSG00000172493(gene)|ensembl:ENST00000307808(transcript)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:2LM0|dip:DIP-56407N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:dfXWN9v1lQ9Tz77hzdYOBy7xn1Q9606 intact-crc:B566A3368B0F4182|rigid:91CmhnEoKa8mJ9lr3rdT3IkeVLI false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:Q9UHB7 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-395282|intact:EBI-1384303|uniprotkb:Q498B2|uniprotkb:Q59FB3|uniprotkb:Q6P592|uniprotkb:Q8TDR1|uniprotkb:Q9P0E4|uniprotkb:B2RP19|uniprotkb:B7WPD2|ensembl:ENSP00000265343 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:aff4_human(display_long)|uniprotkb:AFF4(gene name)|psi-mi:AFF4(display_short)|uniprotkb:AF5Q31(gene name synonym)|uniprotkb:MCEF(gene name synonym)|uniprotkb:ALL1-fused gene from chromosome 5q31 protein(gene name synonym)|uniprotkb:Major CDK9 elongation factor-associated protein(gene name synonym)|uniprotkb:HSPC092(orf name) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179557|imex:IM-17346-156 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_055238.1|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007286"(spermatid development)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0032783"(super elongation complex)|go:"GO:0035327"|interpro:IPR007797(AF-4 proto-oncoprotein)|interpro:IPR043639|interpro:IPR043640|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5JW9|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6K7P|rcsb pdb:6KN5|rcsb pdb:6R80|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000072364(gene)|ensembl:ENST00000265343(transcript)|refseq:XP_005272020.1 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:JTEHIXFmAg6Y1iddSZFgzVGx7/s9606 intact-crc:A73C083F9888CCD0|rigid:t49wi/3LYrsMXKQSgoEs3DesIps false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:O60563 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2479671|ensembl:ENSP00000261900|uniprotkb:O60581|uniprotkb:A9XU13|uniprotkb:E7EX76 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ccnt1_human(display_long)|uniprotkb:CCNT1(gene name)|psi-mi:CCNT1(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179570|imex:IM-17346-157 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF go:"GO:0097322"(7SK snRNA binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR006671(Cyclin, N-terminal)|go:"GO:0070691"(P-TEFb complex)|interpro:IPR013763(Cyclin-related)|interpro:IPR028863|interpro:IPR036915|interpro:IPR043198|mint:O60563|rcsb pdb:2PK2|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000129315(gene)|ensembl:ENST00000261900(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070063"(RNA polymerase binding)|refseq:NP_001231.2|refseq:NP_001264771.1|dip:DIP-29891N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:y80GILqwBbb5hMtl/4U1Y/vNx909606 intact-crc:58191710C185BEAF|rigid:zUDb96PJ6kRaIU8q5LCrEqrwXtM false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:Q9NXF7 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2559096|ensembl:ENSP00000371682|uniprotkb:B3KPB7 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:dca16_human(display_long)|uniprotkb:DCAF16(gene name)|psi-mi:DCAF16(display_short)|uniprotkb:C4orf30(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179583|imex:IM-17346-158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_060211.3|ensembl:ENSG00000163257(gene)|ensembl:ENST00000382247(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR028216|mint:Q9NXF7|reactome:R-HSA-8951664|refseq:NP_001332809.1|refseq:NP_001332810.1|refseq:NP_001332811.1|refseq:NP_001332813.1|refseq:NP_001332814.1|refseq:XP_016863816.1|refseq:XP_016863817.1 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:nw3uabUDsivZMGy04ZZolwJmdeI9606 intact-crc:483A39956C78328E|rigid:MQuEMb6ufGW08sVd3zFUKMj8yuQ false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:P50750 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-1383449|uniprotkb:Q5JU24|uniprotkb:Q5JU25|uniprotkb:Q5U006|uniprotkb:Q96TF1|ensembl:ENSP00000362361 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:cdk9_human(display_long)|uniprotkb:CDK9(gene name)|psi-mi:CDK9(display_short)|uniprotkb:CDC2L4(gene name synonym)|uniprotkb:Cell division protein kinase 9(gene name synonym)|uniprotkb:Serine/threonine-protein kinase PITALRE(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 4(gene name synonym)|uniprotkb:C-2K(gene name synonym)|uniprotkb:TAK(gene name synonym)|uniprotkb:Tat-associated kinase complex catalytic subunit(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179596|imex:IM-17346-159 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001252.1|dip:DIP-29016N|rcsb pdb:4BCI|rcsb pdb:4BCJ|rcsb pdb:4EC8|rcsb pdb:4EC9|rcsb pdb:4IMY|rcsb pdb:4OGR|rcsb pdb:4OR5|rcsb pdb:5L1Z|rcsb pdb:6CYT|rcsb pdb:6GZH|rcsb pdb:6Z45|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-176034|reactome:R-HSA-2173796|rcsb pdb:3MY1|rcsb pdb:3TN8|rcsb pdb:3TNH|rcsb pdb:3TNI|rcsb pdb:4BCF|rcsb pdb:4BCG|rcsb pdb:4BCH|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|reactome:R-HSA-9018519|ensembl:ENSG00000136807(gene)|ensembl:ENST00000373264(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016592"(mediator complex)|go:"GO:0016605"(PML body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031056"(regulation of histone modification)|go:"GO:0031297"(replication fork processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042493"|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070691"(P-TEFb complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1903839"(positive regulation of mRNA 3'-UTR binding)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P50750|rcsb pdb:1PF6|rcsb pdb:3BLH|rcsb pdb:3BLQ|rcsb pdb:3BLR|rcsb pdb:3LQ5|rcsb pdb:3MI9|rcsb pdb:3MIA psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:XSEmM4b5tp/WCJCJxnQYyP0stvM9606 intact-crc:CEB70C289E9050BD|rigid:mrQ1z3JsqNRx58AjLiEOu0r6tPM false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:Q9UK99 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2509901|uniprotkb:B3KY16|uniprotkb:D3DR05|uniprotkb:Q9H0V2|uniprotkb:Q86X90|uniprotkb:Q9NUX2|ensembl:ENSP00000265651 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:fbx3_human(display_long)|uniprotkb:FBXO3(gene name)|psi-mi:FBXO3(display_short)|uniprotkb:FBX3(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179609|imex:IM-17346-160 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_036307.2|refseq:NP_208385.1|dip:DIP-53688N|ensembl:ENSG00000110429(gene)|ensembl:ENST00000265651(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007474(ApaG)|interpro:IPR018958|interpro:IPR028388|interpro:IPR036047|interpro:IPR036767|interpro:IPR037883|rcsb pdb:5HDW psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:zQB8ig3s51tXN81NtMrou84Rv6I9606 intact-crc:4477255ADBE23540|rigid:vBifHWTR0HKj0FvDcB4Z/osfgjk false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:Q99733 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2255116|uniprotkb:B2R6J4|uniprotkb:F5HFY4|ensembl:ENSP00000369915|ensembl:ENSP00000483728 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:np1l4_human(display_long)|uniprotkb:NAP1L4(gene name)|psi-mi:NAP1L4(display_short)|uniprotkb:NAP2(gene name synonym)|uniprotkb:Nucleosome assembly protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179622|imex:IM-17346-161 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_005960.1|ensembl:ENSG00000205531(gene)|ensembl:ENSG00000273562(gene)|ensembl:ENST00000380542(transcript)|ensembl:ENST00000619695(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0051082"(unfolded protein binding)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q99733 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:tES8IJDlW4JONR/pdC8dq49I/7Y9606 intact-crc:E3FBB3FAFB90B8FD|rigid:KrX58anjIF/FO4EDMTFqVNfOr8I false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:O75607 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-721544|uniprotkb:Q9UNY6|intact:EBI-28974425|ensembl:ENSP00000359128 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:npm3_human(display_long)|uniprotkb:NPM3(gene name)|psi-mi:NPM3(display_short) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179635|imex:IM-17346-162 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_008924.1|ensembl:ENSP00000359128|ensembl:ENSG00000107833(gene)|ensembl:ENST00000370110(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006364"(rRNA processing)|go:"GO:0009303"(rRNA transcription)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0042393"(histone binding)|interpro:IPR004301(Nucleoplasmin)|interpro:IPR024057|interpro:IPR036824|mint:O75607 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:lryH+qFG3/zmXWyn25dmU44prpk9606 intact-crc:26B780E18E5B09B4|rigid:lkt5qVvdI5xZhnTd/t9TWK06+kc false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:O15355 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179648|imex:IM-17346-163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:363BB7B8773A6A68|rigid:vbamOuqvh2z2ZCuf+7NXaKFsGhE false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04608 uniprotkb:O43865 intact:EBI-6164389|uniprotkb:O09778 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:tat_hv1h2(display_long)|uniprotkb:tat(gene name)|psi-mi:tat(display_short)|uniprotkb:Transactivating regulatory protein(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179661|imex:IM-17346-164 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0030332"(cyclin binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039525"(modulation by virus of host chromatin organization)|go:"GO:0039586"(modulation by virus of host PP1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042805"(actinin binding)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:1990970"(trans-activation response element binding)|go:"GO:0001070"(RNA-binding transcription regulator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR036963|rcsb pdb:5V61|rcsb pdb:4OR5|interpro:IPR001831("Immunodeficiency virus transactivating regulatory protein (Tat)")|rcsb pdb:3MI9|rcsb pdb:3MIA|refseq:NP_057853.1|rcsb pdb:6CYT|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-176034|rcsb pdb:6MCE|rcsb pdb:6MCF refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0096"(pull down) crc64:4DDC56D979769115 - figure legend:S11f|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:nfZ/HCkCTIeVuIXrHNkRveyVYfM11706 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:55C5E9EDB8503EE6|rigid:bNVIby5y+0D8fdi1JMD0JB0yZcE false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P04618 uniprotkb:Q13123 intact:EBI-6164309 intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301 psi-mi:rev_hv1h2(display_long)|uniprotkb:rev(gene name)|psi-mi:rev(display_short)|uniprotkb:ART/TRS(gene name synonym)|uniprotkb:Anti-repression transactivator(gene name synonym)|uniprotkb:Regulator of expression of viral proteins(gene name synonym) psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym) psi-mi:"MI:0096"(pull down) Jager et al. (2012) imex:IM-17346|pubmed:22190034|psi-mi:"MI:0007" taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6179674|imex:IM-17346-165 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000625(Anti-repression trans-activator protein, REV protein)|rcsb pdb:6HIP|rcsb pdb:7JYA|go:"GO:0051028"(mRNA transport)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0016032"(viral process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042802"(identical protein binding)|go:"GO:0044196"(host cell nucleolus)|refseq:NP_057854.1|dip:DIP-61717N|reactome:R-HSA-162585|reactome:R-HSA-162588|reactome:R-HSA-162592|reactome:R-HSA-162594|reactome:R-HSA-164516|reactome:R-HSA-164525|reactome:R-HSA-164843|reactome:R-HSA-165054|reactome:R-HSA-173107|reactome:R-HSA-175474|reactome:R-HSA-175567|reactome:R-HSA-177539|reactome:R-HSA-180689|reactome:R-HSA-180746|reactome:R-HSA-180910 ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2 psi-mi:"MI:0096"(pull down) - - figure legend:S11g|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/07/09 2014/10/16 rogid:R+Ji+DXMeV/BnOTb7qMiCVxEKRU11706 rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606 intact-crc:0B23CD262F27D9B2|rigid:dTGDjsm0/plOQWbdfBTxeQ2KdFU false tandem tag:c-c("MI:0677") flag tag:c-c("MI:0518") - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)