#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H2K2	uniprotkb:Q06649	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	intact:EBI-5323518	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5323603|imex:IM-16615-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/04	2014/10/16	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090	intact-crc:D5B01FF696BB4597|rigid:o27o4Fzof7H2gR0Qw/3EJMx6YQQ	false	myc tag:?-?	mutation disrupting interaction:423-423|mutation disrupting interaction:413-413|mutation disrupting interaction:418-418|sufficient binding region:413-418|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q06649	uniprotkb:Q9H2K2	intact:EBI-5323518	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5323587|imex:IM-16615-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/04	2014/10/16	rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:5AD488101C8C78CC|rigid:o27o4Fzof7H2gR0Qw/3EJMx6YQQ	false	glutathione s tranferase tag:?-?	flag tag:?-?|sufficient binding region:23..23-776..776	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H2K2	uniprotkb:P78314	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	intact:EBI-727062|uniprotkb:O00500|uniprotkb:O15373|uniprotkb:P78315|uniprotkb:A6NNC2|uniprotkb:B2R5R6|uniprotkb:B4DT04|uniprotkb:D3DVR0|intact:EBI-28985856|ensembl:ENSP00000348685|ensembl:ENSP00000422168|uniprotkb:D6R919	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:3bp2_human(display_long)|uniprotkb:SH3BP2(gene name)|psi-mi:SH3BP2(display_short)|uniprotkb:3BP2(gene name synonym)|uniprotkb:RES4-23(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5328181|imex:IM-16615-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	refseq:NP_001116153.1|refseq:NP_001139327.1|refseq:NP_001139328.1|refseq:NP_003014.3|ensembl:ENSP00000348685|ensembl:ENST00000435136|ensembl:ENSP00000403231|ensembl:ENSP00000422168|ensembl:ENST00000511747|ensembl:ENSP00000424846|ensembl:ENST00000513020|ensembl:ENSP00000424072|ensembl:ENST00000515737|ensembl:ENSP00000422605|ensembl:ENSG00000087266(gene)|ensembl:ENST00000356331(transcript)|ensembl:ENST00000503393(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035847|interpro:IPR035848|interpro:IPR036860|mint:P78314|rcsb pdb:2CR4|rcsb pdb:3TWR	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B|comment:Intense ubiquitylation of proteins present in the 3BP2 complex was induced when TNKS2 was coexpressed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/04	2014/10/16	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	rogid:W+/geQfSvLlQA6UvDPYN4zQCzh89606	intact-crc:5B96854C282CADD6|rigid:H3lqNDHfUdi4K77XwzxLZGsaVy4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H2K2	uniprotkb:Q06649	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	intact:EBI-5323518	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5323559|imex:IM-16615-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1F,  3A, 3C, S3B.|agonist:proteasome inhibitors LLNL and MG132.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/04	2014/10/16	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090	intact-crc:447D62142DF8265F|rigid:o27o4Fzof7H2gR0Qw/3EJMx6YQQ	false	flag tag:?-?	mutation disrupting interaction:413-413|glutathione s tranferase tag:?-?|mutation disrupting interaction:416-416|mutation disrupting interaction:418-418	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NTX7	uniprotkb:Q06649	intact:EBI-722397|uniprotkb:Q6FIB2|uniprotkb:Q7L8H4|uniprotkb:Q96K03|uniprotkb:Q9NTX6|uniprotkb:E1P572|uniprotkb:Q96T06|intact:EBI-28979460|ensembl:ENSP00000357297|ensembl:ENSP00000476814	intact:EBI-5323518	psi-mi:rn146_human(display_long)|uniprotkb:Dactylidin(gene name synonym)|uniprotkb:RNF146(gene name)|psi-mi:RNF146(display_short)|uniprotkb:RING finger protein 146(gene name synonym)|uniprotkb:Iduna(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF146(gene name synonym)	psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5323541|imex:IM-16615-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229773.1|refseq:NP_001229774.1|refseq:NP_001229775.1|refseq:NP_001229778.1|refseq:NP_001229779.1|refseq:NP_001229780.1|refseq:NP_001229781.1|refseq:NP_112225.2|ensembl:ENSP00000357297|ensembl:ENST00000608991|ensembl:ENSP00000477168|ensembl:ENSP00000476814|refseq:NP_001229776.1|refseq:NP_001229777.1|refseq:XP_011534463.1|refseq:XP_011534464.1|refseq:XP_011534465.1|refseq:XP_011534466.1|refseq:XP_006715634.1|refseq:XP_016866825.1|refseq:XP_016866826.1|refseq:XP_016866827.1|refseq:XP_016866828.1|refseq:XP_016866829.1|refseq:XP_016866830.1|refseq:XP_016866831.1|refseq:XP_016866832.1|dip:DIP-52730N|ensembl:ENSG00000118518(gene)|ensembl:ENST00000368314(transcript)|ensembl:ENST00000610153(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0072572"(poly-ADP-D-ribose binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR004170(WWE)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018123|interpro:IPR033509|interpro:IPR037197|interpro:IPR044110|mint:Q9NTX7|rcsb pdb:2D8T|rcsb pdb:3V3L|rcsb pdb:6CF6|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5689880|reactome:R-HSA-8948751	mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3D, 3E|comment:Binding of RNF146 to 3BP2 is ADP-ribosylation dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/04	2014/10/16	rogid:7/KiZcZQYfSeZ6EYqP/FCtk1Mws9606	rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090	intact-crc:1474CA01BCB57F44|rigid:gUuqR3XTHXzcvxnU6CLHRpKZ+bg	false	ha tag:?-?	mutation decreasing interaction:413-413|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q06649	uniprotkb:Q9H2K2	intact:EBI-5323518	intact:EBI-4398527|uniprotkb:Q9H8F2|uniprotkb:Q9HAS4|uniprotkb:B2RBD3|ensembl:ENSP00000360689	psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym)	psi-mi:tnks2_human(display_long)|uniprotkb:TNKS2(gene name)|psi-mi:TNKS2(display_short)|uniprotkb:PARP5B(gene name synonym)|uniprotkb:TANK2(gene name synonym)|uniprotkb:TNKL(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5B(gene name synonym)|uniprotkb:TNKS-2(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase 2(gene name synonym)|uniprotkb:Tankyrase II(gene name synonym)|uniprotkb:Tankyrase-like protein(gene name synonym)|uniprotkb:Tankyrase-related protein(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 6(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-2(gene name synonym)|uniprotkb:Tankyrase-2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5323528|imex:IM-16615-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)	refseq:NP_079511.1|dip:DIP-42098N|rcsb pdb:3P0Q|rcsb pdb:3TWQ|rcsb pdb:3TWR|rcsb pdb:3TWS|rcsb pdb:3TWT|rcsb pdb:3TWU|rcsb pdb:3TWV|rcsb pdb:3TWW|rcsb pdb:3TWX|rcsb pdb:3U9H|rcsb pdb:3U9Y|rcsb pdb:3UA9|rcsb pdb:3W51|rcsb pdb:4AVU|rcsb pdb:4AVW|rcsb pdb:4BFP|rcsb pdb:4BJ9|rcsb pdb:4BJB|rcsb pdb:4BJC|rcsb pdb:4BS4|rcsb pdb:4BU3|rcsb pdb:4BU5|rcsb pdb:4BU6|rcsb pdb:4BU7|rcsb pdb:4BU8|rcsb pdb:4BU9|rcsb pdb:4BUA|rcsb pdb:4BUD|rcsb pdb:4BUE|rcsb pdb:4BUF|rcsb pdb:4BUI|rcsb pdb:4BUS|rcsb pdb:4BUT|rcsb pdb:4BUU|rcsb pdb:4BUV|rcsb pdb:4BUW|rcsb pdb:4BUX|rcsb pdb:4BUY|rcsb pdb:4HKI|rcsb pdb:4HKK|rcsb pdb:4HKN|ensembl:ENSG00000107854(gene)|ensembl:ENST00000371627(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|mint:Q9H2K2|rcsb pdb:2Y0I|rcsb pdb:3KR7|rcsb pdb:3KR8|rcsb pdb:3MHJ|rcsb pdb:3MHK|rcsb pdb:3P0N|rcsb pdb:3P0P|rcsb pdb:6TKP|rcsb pdb:6TKQ|rcsb pdb:6TKR|rcsb pdb:6TKS|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:6TKN|rcsb pdb:4HL5|rcsb pdb:4HLF|rcsb pdb:4HLG|rcsb pdb:4HLH|rcsb pdb:4HLK|rcsb pdb:4HLM|rcsb pdb:4HMH|rcsb pdb:4HYF|rcsb pdb:4IUE|rcsb pdb:4J1Z|rcsb pdb:4J21|rcsb pdb:4J22|rcsb pdb:4J3L|rcsb pdb:4J3M|rcsb pdb:4KZL|rcsb pdb:4KZQ|rcsb pdb:4KZU|rcsb pdb:4L09|rcsb pdb:4L0B|rcsb pdb:4L0I|rcsb pdb:4L0T|rcsb pdb:4L0V|rcsb pdb:4L10|rcsb pdb:4L2F|rcsb pdb:4L2G|rcsb pdb:4L2K|rcsb pdb:4L31|rcsb pdb:4L32|rcsb pdb:4L33|rcsb pdb:4L34|rcsb pdb:4M7B|rcsb pdb:4PML|rcsb pdb:4PNL|rcsb pdb:4PNM|rcsb pdb:4PNN|rcsb pdb:4PNQ|rcsb pdb:4PNR|rcsb pdb:4PNS|rcsb pdb:4PNT|rcsb pdb:4TJU|rcsb pdb:4TJW|rcsb pdb:4TJY|rcsb pdb:4TK0|rcsb pdb:4TK5|rcsb pdb:4TKF|rcsb pdb:4TKG|rcsb pdb:4TKI|rcsb pdb:4UFU|rcsb pdb:4UFY|rcsb pdb:4UHG|rcsb pdb:4UI3|rcsb pdb:4UI4|rcsb pdb:4UI5|rcsb pdb:4UI6|rcsb pdb:4UI7|rcsb pdb:4UI8|rcsb pdb:4UVL|rcsb pdb:4UVN|rcsb pdb:4UVO|rcsb pdb:4UVP|rcsb pdb:4UVS|rcsb pdb:4UVT|rcsb pdb:4UVU|rcsb pdb:4UVV|rcsb pdb:4UVW|rcsb pdb:4UVX|rcsb pdb:4UVY|rcsb pdb:4UVZ|rcsb pdb:4UX4|rcsb pdb:4W5I|rcsb pdb:4Z68|rcsb pdb:5ADQ|rcsb pdb:5ADR|rcsb pdb:5ADS|rcsb pdb:5ADT|rcsb pdb:5AEH|rcsb pdb:5AKU|rcsb pdb:5AKW|rcsb pdb:5AL1|rcsb pdb:5AL2|rcsb pdb:5AL3|rcsb pdb:5AL4|rcsb pdb:5AL5|rcsb pdb:5BXO|rcsb pdb:5BXU|rcsb pdb:5C5P|rcsb pdb:4L0S|rcsb pdb:5C5Q|rcsb pdb:5C5R|rcsb pdb:5DCZ|rcsb pdb:5FPF|rcsb pdb:5FPG|rcsb pdb:5JRT|rcsb pdb:5NOB|rcsb pdb:5NSP|rcsb pdb:5NUT|rcsb pdb:5OWS|rcsb pdb:5OWT|rcsb pdb:6TG4|rcsb pdb:6TKM	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E, 2A-D, 3D-E Supp. Fig. 2A, 2B.|comment:"Wild-Type 3BP2 but not 3BP2 Cherubism mutants Are ribosylated by Tankyrase. Ribosylation induces 3BP2 ubiquitylation and subsequent degradation The Tankyrase binding region, RSPPDG (413-418), was added to the C terminus of the cherubism mutant 3BP2R413Q. Tankyrase was able to bind to the chimeric protein"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/04	2014/10/16	rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090	rogid:pf0mQR/in4ShtYc1xmCF042/v/A9606	intact-crc:617D563196EA8300|rigid:o27o4Fzof7H2gR0Qw/3EJMx6YQQ	false	sufficient binding region:408-420|flag tag:?-?|mutation disrupting interaction:413-413|mutation disrupting interaction:418-418|mutation disrupting interaction:416-416	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95271	uniprotkb:Q06649	intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579	intact:EBI-5323518	psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym)	psi-mi:3bp2_mouse(display_long)|uniprotkb:Sh3bp2(gene name)|psi-mi:Sh3bp2(display_short)|uniprotkb:3bp2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Levaot et al. (2011)	pubmed:22153076|imex:IM-16615	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5328405|imex:IM-16615-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N	mint:Q06649|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|interpro:IPR035847|interpro:IPR035848|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0007165"(signal transduction)|go:"GO:0017124"(SH3 domain binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1E, S2B|comment:3BP2 ADP-ribosylation Is stimulated by TNKS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/04	2014/10/16	rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606	rogid:6mgX1Wc+y+TyO2s56+p2Ineiz8M10090	intact-crc:C79C267845C2DEFB|rigid:xrj9i/uGHH72edzFKo2VG2hiHLc	false	myc tag:?-?	mutation disrupting interaction:413-413|flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)