#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09866	uniprotkb:P09866	intact:EBI-7591539|uniprotkb:Q88665|uniprotkb:Q9DKQ5|uniprotkb:Q9DKQ6|uniprotkb:Q88671|uniprotkb:Q88670|uniprotkb:Q88666|uniprotkb:Q88661|uniprotkb:Q88669|uniprotkb:Q88667|uniprotkb:Q88668|uniprotkb:Q99BK4|uniprotkb:Q88664|uniprotkb:Q88663|uniprotkb:Q9DKQ7|uniprotkb:Q88662|intact:MINT-8373716	intact:EBI-7591539|uniprotkb:Q88665|uniprotkb:Q9DKQ5|uniprotkb:Q9DKQ6|uniprotkb:Q88671|uniprotkb:Q88670|uniprotkb:Q88666|uniprotkb:Q88661|uniprotkb:Q88669|uniprotkb:Q88667|uniprotkb:Q88668|uniprotkb:Q99BK4|uniprotkb:Q88664|uniprotkb:Q88663|uniprotkb:Q9DKQ7|uniprotkb:Q88662|intact:MINT-8373716	psi-mi:polg_den4d(display_long)	psi-mi:polg_den4d(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Cockburn et al. (2012)	doi:10.1038/emboj.2011.439|pubmed:22139356|imex:IM-17558|mint:MINT-8373705	taxid:408871(denv-4)|taxid:408871("Dengue virus type 4 (strain Dominica/814669/1981)")	taxid:408871(denv-4)|taxid:408871("Dengue virus type 4 (strain Dominica/814669/1981)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7591638|mint:MINT-8373784|imex:IM-17558-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|rcsb pdb:5B1C|rcsb pdb:4X42|interpro:IPR027417|interpro:IPR027287|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|rcsb pdb:3UC0|rcsb pdb:2H0P|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR026490|rcsb pdb:3UAJ|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|refseq:NP_073286.1|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026470|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|rcsb pdb:3WE1|interpro:IPR029063|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140272"(exogenous protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038688|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|mint:MINT-8373786(identity)	interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|rcsb pdb:5B1C|rcsb pdb:4X42|interpro:IPR027417|interpro:IPR027287|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|rcsb pdb:3UC0|rcsb pdb:2H0P|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR026490|rcsb pdb:3UAJ|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|refseq:NP_073286.1|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026470|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|rcsb pdb:3WE1|interpro:IPR029063|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140272"(exogenous protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR038688|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR036253|interpro:IPR037172|interpro:IPR043502|interpro:IPR043504|mint:MINT-8373786(identity)	-	comment:mint|comment:"Stoichiometry: 2.0"	comment:mint|comment:"Stoichiometry: 2.0"	comment:mint|figure legend:t1 f1b f3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/05/03	2014/10/16	rogid:IRc+0nz5NwZxq7h0jFiyKOIcJ2k408871	rogid:IRc+0nz5NwZxq7h0jFiyKOIcJ2k408871	intact-crc:72F3D26849AC4E39|rigid:OnhryO16DpYbIFppyTtc0rehAkg	false	binding-associated region:280-710(MINT-8379052)	binding-associated region:280-710(MINT-8379052)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)