#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96RK4 uniprotkb:Q8K2G4 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142816|imex:IM-17355-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - - - figure legend:Fig S1B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:19771CB7CD5A9B17|rigid:YuUVZkIw8reZLtWetEch/kc1fSA false tandem tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96RK4 uniprotkb:Q9CWF6 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892863|ensembl:ENSMUSP00000034206 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142816|imex:IM-17355-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N - - - figure legend:Fig S1B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 intact-crc:19771CB7CD5A9B17|rigid:YuUVZkIw8reZLtWetEch/kc1fSA false tandem tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96RK4 uniprotkb:Q3V3N7 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892836|ensembl:ENSMUSP00000055321 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142816|imex:IM-17355-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 - - crc64:322E9DD4DD554813 figure legend:Fig S1B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 intact-crc:19771CB7CD5A9B17|rigid:YuUVZkIw8reZLtWetEch/kc1fSA false tandem tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96RK4 uniprotkb:Q9CZQ9 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-6127679|uniprotkb:A2AUC7|ensembl:ENSMUSP00000074494 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs5_mouse(display_long)|uniprotkb:Bbs5(gene name)|psi-mi:Bbs5(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_082560.1|ensembl:ENSMUSG00000063145(gene)|ensembl:ENSMUST00000074963(transcript)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|mint:Q9CZQ9|reactome:R-MMU-5620922 - - - figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:tpfXPd3gpQIC6+kp3OOpwiXrZe810090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96RK4 uniprotkb:Q9JHQ5 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-6142879|uniprotkb:Q8BRX8|uniprotkb:Q8CDS2|ensembl:ENSMUSP00000026274 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:lztl1_mouse(display_long)|uniprotkb:Lztfl1(gene name)|psi-mi:Lztfl1(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_201579.1|ensembl:ENSMUSG00000025245(gene)|ensembl:ENSMUST00000026274(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-MMU-5620922 - - - figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:vics60HJsMZiL0vjMBlVW+iGgLk10090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96RK4 uniprotkb:Q811G0 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-6127691|uniprotkb:P97498|uniprotkb:Q3UMR2|uniprotkb:Q7TQH9|uniprotkb:Q8BKD7|uniprotkb:Q8K0T5|ensembl:ENSMUSP00000120927 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:pthb1_mouse(display_long)|uniprotkb:Bbs9(gene name)|psi-mi:Bbs9(display_short)|uniprotkb:Pthb1(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein homolog(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein homolog(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:XP_006510478.1|refseq:XP_006510479.1|refseq:XP_006510480.1|refseq:XP_006510481.1|refseq:XP_006510482.1|refseq:NP_848502.1|refseq:NP_851833.2|ensembl:ENSMUSG00000035919(gene)|ensembl:ENSMUST00000147405(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005929"(cilium)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|reactome:R-MMU-5620922 - - - figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:sZIkJkIaNYEhrEujD3WS4KO76Yw10090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96RK4 uniprotkb:Q8VD72 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - - - figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96RK4 uniprotkb:Q8K2G4 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - - - figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96RK4 uniprotkb:Q9CWF6 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892863|ensembl:ENSMUSP00000034206 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N - - - figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q96RK4 uniprotkb:Q3V3N7 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-2892836|ensembl:ENSMUSP00000055321 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:bbs1_mouse(display_long)|uniprotkb:Bbs1(gene name)|psi-mi:Bbs1(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142835|imex:IM-17355-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 ensembl:ENSMUSG00000006464(gene)|ensembl:ENSMUST00000053506(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001764"(neuron migration)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008104"(protein localization)|go:"GO:0008594"(photoreceptor cell morphogenesis)|go:"GO:0009566"(fertilization)|go:"GO:0016358"(dendrite development)|go:"GO:0021591"(ventricular system development)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042048"(olfactory behavior)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|reactome:R-MMU-5620922|refseq:NP_001028300.1 - - crc64:322E9DD4DD554813 figure legend:Fig 1A , Table S1.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:utrPbnXQaGf4+UPHfWHVb2RSd7Q10090 intact-crc:3683B30AFA48E904|rigid:cztb93RJe05WMWFpNcfZzZoD75Y false tandem tag:n-n - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9CWF6 uniprotkb:Q96RK4 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143009|imex:IM-17355-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:C1422A4D1AB64DE6|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8K2G4 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143009|imex:IM-17355-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:C1422A4D1AB64DE6|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q9JHQ5 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6142879|uniprotkb:Q8BRX8|uniprotkb:Q8CDS2|ensembl:ENSMUSP00000026274 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:lztl1_mouse(display_long)|uniprotkb:Lztfl1(gene name)|psi-mi:Lztfl1(display_short) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143009|imex:IM-17355-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_201579.1|ensembl:ENSMUSG00000025245(gene)|ensembl:ENSMUST00000026274(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-MMU-5620922 - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:vics60HJsMZiL0vjMBlVW+iGgLk10090 intact-crc:C1422A4D1AB64DE6|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8VD72 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143009|imex:IM-17355-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-testis)|taxid:10090(Mus musculus testis) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:C1422A4D1AB64DE6|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q96RK4 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143037|imex:IM-17355-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was well separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-eye)|taxid:10090(Mouse EYE) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 intact-crc:223CD09077BD41F1|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8K2G4 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-2892924|ensembl:ENSMUSP00000103791|uniprotkb:Q8C7G3|uniprotkb:Q8CH00|uniprotkb:Q9CXC2 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:bbs7_mouse(display_long)|uniprotkb:Bbs7(gene name)|psi-mi:Bbs7(display_short)|uniprotkb:Bbs2l1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143037|imex:IM-17355-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N ensembl:ENSMUSG00000037325(gene)|ensembl:ENSMUST00000108156(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|mint:Q8K2G4|reactome:R-MMU-5620922|go:"GO:0007224"(smoothened signaling pathway)|refseq:NP_082086.2|dip:DIP-60353N - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was well separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-eye)|taxid:10090(Mouse EYE) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:7StHJMzhLoqoT+8pRQuNHTdRVW810090 intact-crc:223CD09077BD41F1|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q9JHQ5 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6142879|uniprotkb:Q8BRX8|uniprotkb:Q8CDS2|ensembl:ENSMUSP00000026274 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:lztl1_mouse(display_long)|uniprotkb:Lztfl1(gene name)|psi-mi:Lztfl1(display_short) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143037|imex:IM-17355-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_201579.1|ensembl:ENSMUSG00000025245(gene)|ensembl:ENSMUST00000026274(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-MMU-5620922 - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was well separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-eye)|taxid:10090(Mouse EYE) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:vics60HJsMZiL0vjMBlVW+iGgLk10090 intact-crc:223CD09077BD41F1|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CWF6 uniprotkb:Q8VD72 intact:EBI-2892863|ensembl:ENSMUSP00000034206 intact:EBI-6127721|uniprotkb:Q9DCP7|ensembl:ENSMUSP00000078148 psi-mi:bbs2_mouse(display_long)|uniprotkb:Bbs2(gene name)|psi-mi:Bbs2(display_short) psi-mi:ttc8_mouse(display_long)|uniprotkb:Ttc8(gene name)|psi-mi:Ttc8(display_short)|uniprotkb:Bbs8(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 8 protein homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143037|imex:IM-17355-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0044321"(response to leptin)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903441"(protein localization to ciliary membrane)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-MMU-5620922|go:"GO:0043005"(neuron projection)|ensembl:ENSMUSG00000031755(gene)|ensembl:ENSMUST00000034206(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0031514"(motile cilium)|go:"GO:0032420"(stereocilium)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042311"(vasodilation)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|refseq:NP_080392.1|dip:DIP-60351N refseq:NP_083829.1|refseq:NP_938053.1|dip:DIP-60354N|ensembl:ENSMUSG00000021013(gene)|ensembl:ENSMUST00000079146(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007411"(axon guidance)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034464"(BBSome)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0048560"(establishment of anatomical structure orientation)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060219"(camera-type eye photoreceptor cell differentiation)|go:"GO:0060271"(cilium assembly)|go:"GO:0061326"(renal tubule development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:1903251"(multi-ciliated epithelial cell differentiation)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028796|reactome:R-MMU-5620922 - - - figure legend:Fig 1E|comment:The peak of LZTFL1 was well separated from that of the BBSome.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-eye)|taxid:10090(Mouse EYE) - 2012/06/08 2014/10/16 rogid:KRmLQ4eWnXQJKSRCOQ7pIDAAIIw10090 rogid:HgXZsyzU5TcN+4XsgdXlHygMHUk10090 intact-crc:223CD09077BD41F1|rigid:bzEreTbYKNQxYoELe3/dW/CzEvE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NQ48 uniprotkb:Q3SYG4 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142898|imex:IM-17355-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig 1B , Table S2.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:E0E312867B1974E1|rigid:aZty4W3zgAvIbvgBH7oRCUexJps false tandem tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9NQ48 uniprotkb:Q9BXC9 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-748297|uniprotkb:Q96CM0|uniprotkb:Q96SN9|ensembl:ENSP00000245157 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:bbs2_human(display_long)|uniprotkb:BBS2(gene name)|psi-mi:BBS2(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142898|imex:IM-17355-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:NP_114091.3|interpro:IPR016616(Bardet-Biedl syndrome 2 protein)|interpro:IPR029333|interpro:IPR029429|interpro:IPR029430|interpro:IPR036322|reactome:R-HSA-5620922|ensembl:ENSG00000125124(gene)|ensembl:ENST00000245157(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0016020"(membrane)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0032402"(melanosome transport)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0031514"(motile cilium)|dip:DIP-46563N - - - figure legend:Fig 1B , Table S2.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:yRgKTZdhdvhuMd44Q6Dvo6WN52w9606 intact-crc:E0E312867B1974E1|rigid:aZty4W3zgAvIbvgBH7oRCUexJps false tandem tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9NQ48 uniprotkb:Q9NQ48 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142898|imex:IM-17355-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 - - - figure legend:Fig 1B , Table S2.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 intact-crc:E0E312867B1974E1|rigid:aZty4W3zgAvIbvgBH7oRCUexJps false tandem tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9NQ48 uniprotkb:Q8IWZ6 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:"MI:0676"(tandem affinity purification) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142898|imex:IM-17355-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) - - - figure legend:Fig 1B , Table S2.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 intact-crc:E0E312867B1974E1|rigid:aZty4W3zgAvIbvgBH7oRCUexJps false tandem tag:?-? - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9NQ48 uniprotkb:Q3SYG4 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143342|imex:IM-17355-16 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N - - - figure legend:Fig S2F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:D0C79F2050052727|rigid:uYUdB3kxyhnvlJb+eo/hMqbvb1s false flag tag:?-? necessary binding region:685-765|ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NQ48 uniprotkb:Q9NQ48 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143315|imex:IM-17355-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 - - - figure legend:Fig S2D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 intact-crc:4782CC1B2A090E08|rigid:lyk54s4B1dbspp8B5Z7zbBnWgYY false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3SYG4 uniprotkb:Q9NQ48 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142988|imex:IM-17355-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 - - - figure legend:Fig 1D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 intact-crc:EDFE6EC536FFFC9D|rigid:uYUdB3kxyhnvlJb+eo/hMqbvb1s false ha tag:?-? sufficient binding region:145-299|myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3SYG4 uniprotkb:Q9NQ48 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6142980|imex:IM-17355-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 - - - figure legend:Fig 1C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 intact-crc:68B5C8482CD4C7D7|rigid:uYUdB3kxyhnvlJb+eo/hMqbvb1s false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3SYG4 uniprotkb:Q9NQ48 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:"MI:0813"(proximity ligation assay) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-6143088|imex:IM-17355-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 go:"GO:0005737"(cytoplasm) - - figure legend:Fig 2C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2012/06/08 2014/10/16 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 intact-crc:5B437F1D09935102|rigid:uYUdB3kxyhnvlJb+eo/hMqbvb1s false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9NQ48 uniprotkb:Q3SYG4 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-2826852|uniprotkb:Q8N570|uniprotkb:P78514|uniprotkb:Q9Y6A0|uniprotkb:Q9Y699|uniprotkb:Q99854|uniprotkb:Q7KYS7|uniprotkb:Q99844|uniprotkb:Q7KYS6|ensembl:ENSP00000242067|uniprotkb:E9PDC9 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:pthb1_human(display_long)|uniprotkb:PTHB1(gene name synonym)|uniprotkb:Parathyroid hormone-responsive B1 gene protein(gene name synonym)|uniprotkb:Bardet-Biedl syndrome 9 protein(gene name synonym)|uniprotkb:BBS9(gene name)|psi-mi:BBS9(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6143104|imex:IM-17355-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:NP_001028776.1|refseq:NP_001028777.1|refseq:NP_055266.2|refseq:NP_940820.1|refseq:NP_001334965.1|ensembl:ENSG00000122507(gene)|ensembl:ENST00000242067(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|interpro:IPR026511|interpro:IPR028073|interpro:IPR028074|rcsb pdb:4YD8|rcsb pdb:6XT9|reactome:R-HSA-5620922|dip:DIP-60358N go:"GO:0031514"(motile cilium) - - figure legend:Fig 2E|comment:Over-expression of wild-type LZTFL1 inhibited ciliary localization of BBS9. Removal of the N-terminal 70 amino acids from LZTFL1 and the KR mutation increase ciliary localisation.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:eKl4Nncm7CuSPi1GKrGhJ5IJsFY9606 intact-crc:9E4627BE6D685B0F|rigid:uYUdB3kxyhnvlJb+eo/hMqbvb1s false myc tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q8IWZ6 uniprotkb:P56726 intact:EBI-1806001|uniprotkb:Q4W5P8|uniprotkb:Q8N581|uniprotkb:Q9NVI4|ensembl:ENSP00000264499 intact:EBI-6143138|ensembl:ENSMUSP00000001812 psi-mi:bbs7_human(display_long)|uniprotkb:BBS7(gene name)|psi-mi:BBS7(display_short)|uniprotkb:BBS2L1(gene name synonym)|uniprotkb:BBS2-like protein 1(gene name synonym) psi-mi:smo_mouse(display_long)|uniprotkb:Smo(gene name)|psi-mi:Smo(display_short)|uniprotkb:Smoh(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143241|imex:IM-17355-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060660.2|refseq:NP_789794.1|dip:DIP-46566N|ensembl:ENSG00000138686(gene)|ensembl:ENST00000264499(transcript)|go:"GO:0001654"(eye development)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0032402"(melanosome transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043005"(neuron projection)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0046907"(intracellular transport)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051877"(pigment granule aggregation in cell center)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060173"(limb development)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1903929"(primary palate development)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR016575(Bardet-Biedl syndrome 7 protein)|interpro:IPR036322|reactome:R-HSA-5620922|go:"GO:0034464"(BBSome) refseq:NP_795970.3|ensembl:ENSMUSG00000001761(gene)|ensembl:ENSMUST00000001812(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001503"(ossification)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007389"(pattern specification process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007494"(midgut development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048468"(cell development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:6O3C|reactome:R-MMU-5610787|reactome:R-MMU-5620922|reactome:R-MMU-5632684|reactome:R-MMU-5635838|go:"GO:0097731"(9+0 non-motile cilium) - - - figure legend:Fig 4C/D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2012/06/08 2014/10/16 rogid:8Czybdr0ILmxLq6yP0gyNPilfzE9606 rogid:Q/AY1Bl/MhDt/Br2GEfBFSXjv+M10090 intact-crc:EF3BFA2E1B4C48B7|rigid:t6BOciFR9SUORQh4QcWzr7X+/Eg false ha tag:?-? myc tag:?-?|necessary binding region:542-551 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P56726 uniprotkb:Q8N3I7 intact:EBI-6143138|ensembl:ENSMUSP00000001812 intact:EBI-2892592|intact:EBI-28972415|uniprotkb:Q6PKN0|uniprotkb:D3DPC3|ensembl:ENSP00000295240 psi-mi:smo_mouse(display_long)|uniprotkb:Smo(gene name)|psi-mi:Smo(display_short)|uniprotkb:Smoh(gene name synonym) psi-mi:bbs5_human(display_long)|uniprotkb:BBS5(gene name)|psi-mi:BBS5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143233|imex:IM-17355-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_795970.3|ensembl:ENSMUSG00000001761(gene)|ensembl:ENSMUST00000001812(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001503"(ossification)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007389"(pattern specification process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007494"(midgut development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048468"(cell development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:6O3C|reactome:R-MMU-5610787|reactome:R-MMU-5620922|reactome:R-MMU-5632684|reactome:R-MMU-5635838|go:"GO:0097731"(9+0 non-motile cilium) ensembl:ENSP00000295240|ensembl:ENST00000392663|ensembl:ENSP00000376431|refseq:NP_689597.1|dip:DIP-60357N|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0046907"(intracellular transport)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006606(Protein of unknown function DUF1448)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014003(Protein of unknown function DM16)|interpro:IPR030804|rcsb pdb:6XTB|reactome:R-HSA-5620922|ensembl:ENSG00000163093(gene)|ensembl:ENST00000295240(transcript)|go:"GO:0001947"(heart looping)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0015031"(protein transport)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0034451"(centriolar satellite) - - - figure legend:Fig 4C/D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2012/06/08 2014/10/16 rogid:Q/AY1Bl/MhDt/Br2GEfBFSXjv+M10090 rogid:c0TpyFlyIP03JBq2ONTR3YL1bf09606 intact-crc:9C2B81A87C8FD021|rigid:AwisaDTVBQb1ub3QyIeoWSc4oNo false myc tag:?-?|necessary binding region:542-551 ha tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q96RK4 uniprotkb:P56726 intact:EBI-1805814|uniprotkb:Q53DZ5|uniprotkb:Q8NHU9|uniprotkb:Q96H45|uniprotkb:B4E178|ensembl:ENSP00000268057 intact:EBI-6143138|ensembl:ENSMUSP00000001812 psi-mi:bbs4_human(display_long)|uniprotkb:BBS4(gene name)|psi-mi:BBS4(display_short) psi-mi:smo_mouse(display_long)|uniprotkb:Smo(gene name)|psi-mi:Smo(display_short)|uniprotkb:Smoh(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143225|imex:IM-17355-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016877940.1|refseq:XP_016877941.1|refseq:XP_016877942.1|refseq:XP_016877943.1|refseq:XP_011520150.1|refseq:XP_011520151.1|refseq:NP_149017.2|refseq:NP_001307594.1|refseq:NP_001239607.1|dip:DIP-46540N|ensembl:ENSG00000140463(gene)|ensembl:ENST00000268057(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007286"(spermatid development)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0015031"(protein transport)|go:"GO:0016358"(dendrite development)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0021756"(striatum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030534"(adult behavior)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031514"(motile cilium)|go:"GO:0032402"(melanosome transport)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034452"(dynactin binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0034464"(BBSome)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038108"(negative regulation of appetite by leptin-mediated signaling pathway)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050893"(sensory processing)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0060296"(regulation of cilium beat frequency involved in ciliary motility)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0097730"(non-motile cilium)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR028786|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_795970.3|ensembl:ENSMUSG00000001761(gene)|ensembl:ENSMUST00000001812(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001503"(ossification)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007389"(pattern specification process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007494"(midgut development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048468"(cell development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:6O3C|reactome:R-MMU-5610787|reactome:R-MMU-5620922|reactome:R-MMU-5632684|reactome:R-MMU-5635838|go:"GO:0097731"(9+0 non-motile cilium) - - - figure legend:Fig 4C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2012/06/08 2014/10/16 rogid:3qsiARZJocEgNJjKuItz0Pv6mTA9606 rogid:Q/AY1Bl/MhDt/Br2GEfBFSXjv+M10090 intact-crc:E1EFE95E73A08FFA|rigid:JAjPmYby277y6DQ+Ft+/xbzS4iA false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8NFJ9 uniprotkb:P56726 intact:EBI-1805484|uniprotkb:Q32MN0|uniprotkb:Q96SN4|uniprotkb:Q32MM9|ensembl:ENSP00000317469 intact:EBI-6143138|ensembl:ENSMUSP00000001812 psi-mi:bbs1_human(display_long)|uniprotkb:BBS1(gene name)|psi-mi:BBS1(display_short)|uniprotkb:BBS2L2(gene name synonym)|uniprotkb:BBS2-like protein 2(gene name synonym) psi-mi:smo_mouse(display_long)|uniprotkb:Smo(gene name)|psi-mi:Smo(display_short)|uniprotkb:Smoh(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143136|imex:IM-17355-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078925.3|dip:DIP-46564N|ensembl:ENSG00000174483(gene)|ensembl:ENST00000318312(transcript)|go:"GO:0005113"(patched binding)|go:"GO:0005119"(smoothened binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0007601"(visual perception)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0034464"(BBSome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0050896"(response to stimulus)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR028784|interpro:IPR032728|rcsb pdb:6XT9|reactome:R-HSA-5620922 refseq:NP_795970.3|ensembl:ENSMUSG00000001761(gene)|ensembl:ENSMUST00000001812(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001503"(ossification)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001947"(heart looping)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003140"(determination of left/right asymmetry in lateral mesoderm)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005929"(cilium)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007228"(positive regulation of hh target transcription factor activity)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007371"(ventral midline determination)|go:"GO:0007389"(pattern specification process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007494"(midgut development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021696"(cerebellar cortex morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021910"(smoothened signaling pathway involved in ventral spinal cord patterning)|go:"GO:0021938"(smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation)|go:"GO:0021953"(central nervous system neuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048468"(cell development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051451"(myoblast migration)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060242"(contact inhibition)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0061053"(somite development)|go:"GO:0061113"(pancreas morphogenesis)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0072285"(mesenchymal to epithelial transition involved in metanephric renal vesicle formation)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0001708"(cell fate specification)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000826"(regulation of heart morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026544|interpro:IPR035683|interpro:IPR036790|interpro:IPR041771|rcsb pdb:6O3C|reactome:R-MMU-5610787|reactome:R-MMU-5620922|reactome:R-MMU-5632684|reactome:R-MMU-5635838|go:"GO:0097731"(9+0 non-motile cilium) - - - figure legend:Fig 4C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line) - 2012/06/08 2014/10/16 rogid:llE02FVGJZcnFUY1VgTFvCtlvtM9606 rogid:Q/AY1Bl/MhDt/Br2GEfBFSXjv+M10090 intact-crc:58805FEF60C48A88|rigid:NDxFocxnWC2DAGgwynsi6btj6J8 false ha tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NQ48 uniprotkb:Q9NQ48 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 intact:EBI-2824799|uniprotkb:Q9NQ56|uniprotkb:Q8TC61|ensembl:ENSP00000296135|uniprotkb:B3KSI9|uniprotkb:B4E0K7 psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:lztl1_human(display_long)|uniprotkb:LZTFL1(gene name)|psi-mi:LZTFL1(display_short) psi-mi:"MI:0030"(cross-linking study) Seo et al. (2011) imex:IM-17355|pubmed:22072986 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6143334|imex:IM-17355-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 refseq:XP_011532140.1|ensembl:ENSG00000163818(gene)|ensembl:ENST00000296135(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1903565"(negative regulation of protein localization to cilium)|go:"GO:1903568"(negative regulation of protein localization to ciliary membrane)|interpro:IPR026157|reactome:R-HSA-5620922|refseq:NP_065080.1|refseq:NP_001263307.1|refseq:NP_001263308.1|refseq:XP_016862133.1 - - - figure legend:Fig S2E|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Diabetes - Interactions investigated in the context of Diabetes|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/06/08 2014/10/16 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 rogid:vDJy2jOk5yTJBG/rTO7L+jlCSp89606 intact-crc:EE6B717AD0BDD626|rigid:9POWsExzah2VDy8mbQALD3YyE0g false - - 2 0 psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)