#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5D1E7	uniprotkb:P51617	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326057|imex:IM-16634-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 5C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606	intact-crc:1A3E549F3786DBC2|rigid:2NCmg1Otm11a65vs+jlplZZxtLA	false	glutathione s tranferase tag:?-?	his tag:n-n|sufficient binding region:194-712	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5D1E7	uniprotkb:O14920	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326016|imex:IM-16634-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 2E, 2F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:E175149510B3B0E4|rigid:RaSCx7QQO4Fnx/losIB/Tj1wWuQ	false	glutathione s tranferase tag:?-?|mutation decreasing interaction:435-435|mutation decreasing interaction:439-439,435-435|mutation decreasing interaction:439-439	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P25963	uniprotkb:O14920	intact:EBI-307386|ensembl:ENSP00000216797|uniprotkb:B2R8L6	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:ikba_human(display_long)|uniprotkb:NFKBIA(gene name)|psi-mi:NFKBIA(display_short)|uniprotkb:IKBA(gene name synonym)|uniprotkb:MAD3(gene name synonym)|uniprotkb:NFKBI(gene name synonym)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Major histocompatibility complex enhancer-binding protein MAD3(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326006|imex:IM-16634-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000100906(gene)|ensembl:ENST00000216797(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|refseq:NP_065390.1|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:P25963|rcsb pdb:1IKN|rcsb pdb:1NFI|rcsb pdb:6TTU|rcsb pdb:6Y1J|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607764|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|reactome:R-HSA-9020702|reactome:R-HSA-933542|dip:DIP-139N	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Fig. 2E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/12	2014/10/16	rogid:LXYgOHjWhEj5sPeyBEi9kV4ZBP89606	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:BDBB7C2512F18DF6|rigid:Npc10m833ra1+/T8jvEvVHUVPU4	false	glutathione s tranferase tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5D1E7	uniprotkb:O14920	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326085|imex:IM-16634-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:8F19956A5B451D96|rigid:N0BduVFIyKWwR00lmf5OR2Z4EOE	false	mutation disrupting interaction:435-435,439-439|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5D1E7	uniprotkb:Q9Y297	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326085|imex:IM-16634-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606	intact-crc:8F19956A5B451D96|rigid:N0BduVFIyKWwR00lmf5OR2Z4EOE	false	mutation disrupting interaction:435-435,439-439|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5D1E7	uniprotkb:P51617	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326099|imex:IM-16634-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606	intact-crc:FD30C5348E9541DB|rigid:2NCmg1Otm11a65vs+jlplZZxtLA	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5D1E7	uniprotkb:O14920	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326107|imex:IM-16634-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S8A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:02BC67DD5C41E10C|rigid:RaSCx7QQO4Fnx/losIB/Tj1wWuQ	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q5D1E7	uniprotkb:O14920	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326124|imex:IM-16634-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:77BCFD00B230FFC6|rigid:RaSCx7QQO4Fnx/losIB/Tj1wWuQ	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5D1E7	uniprotkb:P51617	intact:EBI-5326026|uniprotkb:Q3U8J3|uniprotkb:Q3UE76|uniprotkb:Q8JZW9|uniprotkb:Q922T4|ensembl:ENSMUSP00000037172	intact:EBI-358664|uniprotkb:Q7Z5V4|uniprotkb:Q96RL2|intact:EBI-28987029|ensembl:ENSP00000358997|uniprotkb:D3DWW4|uniprotkb:D3DWW3|uniprotkb:Q96C06	psi-mi:zc12a_mouse(display_long)|uniprotkb:Zc3h12a(gene name)|psi-mi:Zc3h12a(display_short)|uniprotkb:Mcpip(gene name synonym)|uniprotkb:Mcpip1(gene name synonym)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:irak1_human(display_long)|uniprotkb:IRAK1(gene name)|psi-mi:IRAK1(display_short)|uniprotkb:IRAK(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326428|imex:IM-16634-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:2N5J|rcsb pdb:2N5K|rcsb pdb:2N5L|rcsb pdb:5H9V|rcsb pdb:5H9W|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|refseq:NP_694799.1|ensembl:ENSMUSG00000042677(gene)|ensembl:ENSMUST00000036188(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)	go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035533|interpro:IPR035536|mint:P51617|rcsb pdb:6BFN|ensembl:ENSG00000184216(gene)|ensembl:ENST00000369980(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004704"(NF-kappaB-inducing kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0007568"(aging)|go:"GO:0010008"(endosome membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|refseq:NP_001020413.1|refseq:NP_001020414.1|refseq:NP_001560.2|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-6811558|reactome:R-HSA-8986944|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975871|ensembl:ENST00000369974|ensembl:ENSP00000358997|ensembl:ENST00000393687|ensembl:ENSP00000377291|ensembl:ENSP00000358991|dip:DIP-397N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/01/12	2014/10/16	rogid:9CBtwEZKerb674zLeyUet/eC4A410090	rogid:q+oAzeVuuQvO24HkoHx6PKK7XUY9606	intact-crc:D97365DAA4AF72FB|rigid:2NCmg1Otm11a65vs+jlplZZxtLA	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5D1E8	uniprotkb:O14920	intact:EBI-747793|uniprotkb:Q6I9Z1|uniprotkb:Q9H5P1|uniprotkb:D3DPT0|ensembl:ENSP00000362179	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:zc12a_human(display_long)|uniprotkb:MCPIP(gene name synonym)|uniprotkb:MCPIP1(gene name synonym)|uniprotkb:ZC3H12A(gene name)|psi-mi:ZC3H12A(display_short)|uniprotkb:Monocyte chemotactic protein-induced protein 1(gene name synonym)|uniprotkb:Regnase-1(gene name synonym)|uniprotkb:Zinc finger CCCH domain-containing protein 12A(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Iwasaki et al. (2011)	pubmed:22037600|imex:IM-16634	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5326444|imex:IM-16634-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079355.2|refseq:NP_001310479.1|ensembl:ENSG00000163874(gene)|ensembl:ENST00000373087(transcript)|go:"GO:0000294"(nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002757"(immune response-activating signal transduction)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004532"(exoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007399"(nervous system development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030867"(rough endoplasmic reticulum membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043022"(ribosome binding)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:0098586"(cellular response to virus)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|interpro:IPR021869|interpro:IPR040546|interpro:IPR040757|rcsb pdb:3V32|rcsb pdb:3V33|rcsb pdb:3V34|go:"GO:1900745"(positive regulation of p38MAPK cascade)	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S8B|agonist:IL-1b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/12	2014/10/16	rogid:3FqqH/XrYjHaa5oJpPXvfYwHKCQ9606	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	intact-crc:BADC2F9D04E60B8D|rigid:0w4htdp6ZNRH1XHSO2h9QcmeHAE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)