#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08649	uniprotkb:P02309	intact:EBI-6648|uniprotkb:D6W2U6|ensemblfungi:YOR244W	intact:EBI-8113|uniprotkb:D6VQ10|ensemblfungi:YBR009C|ensemblfungi:YNL030W	psi-mi:esa1_yeast(display_long)|uniprotkb:ESA1(gene name)|psi-mi:ESA1(display_short)|uniprotkb:O5257(orf name)|uniprotkb:YOR244W(locus name)	psi-mi:h4_yeast(display_long)|uniprotkb:N2752(orf name)|uniprotkb:YBR0122(orf name)|uniprotkb:YBR009C(locus name)|uniprotkb:YNL030W(locus name)|uniprotkb:HHF1(gene name)|psi-mi:HHF1(display_short)|uniprotkb:HHF2(gene name)|psi-mi:HHF2(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489452|mint:MINT-8328142|imex:IM-16687-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014887.3|sgd:S000005770|mint:Q08649|dip:DIP-4115N|ensemblfungi:YOR244W(gene)|ensemblfungi:YOR244W_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000785"(chromatin)|go:"GO:0001207"(obsolete histone displacement)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006354"(DNA-templated transcription, elongation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140068"(histone crotonyltransferase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR040706|rcsb pdb:1FY7|rcsb pdb:1MJ9|rcsb pdb:1MJA|rcsb pdb:1MJB|rcsb pdb:2RNZ|rcsb pdb:2RO0|rcsb pdb:3TO6|rcsb pdb:3TO7|rcsb pdb:3TO9|rcsb pdb:5J9Q|rcsb pdb:5J9T|rcsb pdb:5J9U|rcsb pdb:5J9W|reactome:R-SCE-9018519|mint:MINT-8328145(identity)	refseq:NP_009563.1|refseq:NP_014368.1|sgd:S000000213|sgd:S000004975|dip:DIP-418N|mint:P02309|ensemblfungi:YBR009C(gene)|ensemblfungi:YBR009C_mRNA(transcript)|ensemblfungi:YNL030W(gene)|ensemblfungi:YNL030W_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|interpro:IPR001951(Histone H4)|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1E6I|rcsb pdb:1ID3|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2E3K|rcsb pdb:2FSB|rcsb pdb:2H2H|rcsb pdb:2L5A|rcsb pdb:2QQF|rcsb pdb:2QQG|rcsb pdb:3TO6|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:4TWI|rcsb pdb:4TWJ|rcsb pdb:5W0V|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6QLD|rcsb pdb:6RXJ|rcsb pdb:6RXK|rcsb pdb:6RXL|rcsb pdb:6RXM|rcsb pdb:6RXO|rcsb pdb:6RXP|rcsb pdb:6RXQ|rcsb pdb:6RXR|rcsb pdb:7K78|rcsb pdb:7K7G|reactome:R-SCE-2299718|reactome:R-SCE-2559580|reactome:R-SCE-3214842|reactome:R-SCE-3214847|reactome:R-SCE-3214858|reactome:R-SCE-4551638|reactome:R-SCE-9018519|mint:MINT-8328144(identity)	-	crc64:9E970F744D0B9E18	crc64:69B7D1F89E62DE41	comment:mint|figure legend:t1 f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:Zf0JVjFFEPhiL20FFOx2+dhO950559292	rogid:wGtUrumyxGKsW9BEzkBW3FwvwUo559292	intact-crc:5D583EFE2E01779E|rigid:wn3y7NXc3Va7gSf5Q42sVAdt350	false	binding-associated region:160-435(MINT-8328154)	binding-associated region:11-22(MINT-8328150)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53686	uniprotkb:Q08649	intact:EBI-2070504|uniprotkb:D6W3Z7|ensemblfungi:YPL015C	intact:EBI-6648|uniprotkb:D6W2U6|ensemblfungi:YOR244W	psi-mi:hst2_yeast(display_long)|uniprotkb:HST2(gene name)|psi-mi:HST2(display_short)|uniprotkb:Homologous to SIR2 protein 2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym)|uniprotkb:LPA2C(orf name)|uniprotkb:YPL015C(locus name)	psi-mi:esa1_yeast(display_long)|uniprotkb:ESA1(gene name)|psi-mi:ESA1(display_short)|uniprotkb:O5257(orf name)|uniprotkb:YOR244W(locus name)	psi-mi:"MI:0406"(deacetylase assay)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489495|mint:MINT-8328388|imex:IM-16687-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_015310.1|sgd:S000005936|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|rcsb pdb:1Q14|rcsb pdb:1Q17|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2OD2|rcsb pdb:2OD7|rcsb pdb:2OD9|rcsb pdb:2QQF|rcsb pdb:2QQG|interpro:IPR026590|interpro:IPR029035|interpro:IPR026591|ensemblfungi:YPL015C(gene)|ensemblfungi:YPL015C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016740"(transferase activity)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070933"(histone H4 deacetylation)|mint:MINT-8328390(identity)	refseq:NP_014887.3|sgd:S000005770|mint:Q08649|dip:DIP-4115N|ensemblfungi:YOR244W(gene)|ensemblfungi:YOR244W_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000785"(chromatin)|go:"GO:0001207"(obsolete histone displacement)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006354"(DNA-templated transcription, elongation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140068"(histone crotonyltransferase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR040706|rcsb pdb:1FY7|rcsb pdb:1MJ9|rcsb pdb:1MJA|rcsb pdb:1MJB|rcsb pdb:2RNZ|rcsb pdb:2RO0|rcsb pdb:3TO6|rcsb pdb:3TO7|rcsb pdb:3TO9|rcsb pdb:5J9Q|rcsb pdb:5J9T|rcsb pdb:5J9U|rcsb pdb:5J9W|reactome:R-SCE-9018519|mint:MINT-8328394(identity)	-	-	crc64:9E970F744D0B9E18	comment:homomint|comment:mint|figure legend:t2 f1f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:8xx/gaYzzVJ7p2xhvQrNv9Lpq6s559292	rogid:Zf0JVjFFEPhiL20FFOx2+dhO950559292	intact-crc:8E27B312B508F0BB|rigid:Von5/tZ6KRHBjp5ce/i7jIbcDBU	false	-	binding-associated region:160-435(MINT-8328395)|monoacetylated residue:262-262(MINT-8359813)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9H7Z6	uniprotkb:P53686	intact:EBI-896414|uniprotkb:Q659G0|uniprotkb:Q7LC17|uniprotkb:Q8IY59|uniprotkb:Q8WYB4|uniprotkb:Q8WZ14|uniprotkb:Q9HAC5|uniprotkb:Q9NR35|uniprotkb:A8K4Z1|intact:EBI-2560822|uniprotkb:G5E9P2|ensembl:ENSP00000219797|ensembl:ENSP00000456933	intact:EBI-2070504|uniprotkb:D6W3Z7|ensemblfungi:YPL015C	psi-mi:kat8_human(display_long)|uniprotkb:KAT8(gene name)|psi-mi:KAT8(display_short)|uniprotkb:MOF(gene name synonym)|uniprotkb:PP7073(orf name)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1(gene name synonym)|uniprotkb:MYST1(gene name synonym)|uniprotkb:Lysine acetyltransferase 8(gene name synonym)	psi-mi:hst2_yeast(display_long)|uniprotkb:HST2(gene name)|psi-mi:HST2(display_short)|uniprotkb:Homologous to SIR2 protein 2(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 2(gene name synonym)|uniprotkb:LPA2C(orf name)|uniprotkb:YPL015C(locus name)	psi-mi:"MI:0406"(deacetylase assay)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0197"(deacetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489514|mint:MINT-8328403|imex:IM-16687-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115564.2|refseq:NP_892003.2|ensembl:ENSG00000103510(gene)|ensembl:ENST00000219797(transcript)|ensembl:ENST00000543774(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000776"(kinetochore)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0043995"("histone acetyltransferase activity (H4-K5 specific)")|go:"GO:0043996"("histone acetyltransferase activity (H4-K8 specific)")|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046972"("histone acetyltransferase activity (H4-K16 specific)")|go:"GO:0071339"(MLL1 complex)|go:"GO:0072487"(MSL complex)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037906|interpro:IPR040706|mint:Q9H7Z6|rcsb pdb:2GIV|rcsb pdb:2PQ8|rcsb pdb:2Y0M|rcsb pdb:3QAH|rcsb pdb:3TOA|rcsb pdb:3TOB|rcsb pdb:4DNC|rcsb pdb:5H43|rcsb pdb:5J8C|rcsb pdb:5J8F|rcsb pdb:5WCI|rcsb pdb:6BA2|rcsb pdb:6BA4|rcsb pdb:6CT2|rcsb pdb:6OIN|rcsb pdb:6OIO|rcsb pdb:6OIP|rcsb pdb:6OIQ|rcsb pdb:6OIR|rcsb pdb:6OWH|rcsb pdb:6OWI|rcsb pdb:6PD8|rcsb pdb:6PD9|rcsb pdb:6PDA|rcsb pdb:6PDB|rcsb pdb:6PDC|rcsb pdb:6PDD|rcsb pdb:6PDE|rcsb pdb:6PDF|rcsb pdb:6PDG|rcsb pdb:7CMR|reactome:R-HSA-3214847|mint:MINT-8328407(identity)	refseq:NP_015310.1|sgd:S000005936|interpro:IPR017328(NAD-dependent deacetylase sirtuin-2, eukaryota)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|rcsb pdb:1Q14|rcsb pdb:1Q17|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2OD2|rcsb pdb:2OD7|rcsb pdb:2OD9|rcsb pdb:2QQF|rcsb pdb:2QQG|interpro:IPR026590|interpro:IPR029035|interpro:IPR026591|ensemblfungi:YPL015C(gene)|ensemblfungi:YPL015C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016740"(transferase activity)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0031939"(obsolete negative regulation of chromatin silencing at telomere)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070933"(histone H4 deacetylation)|mint:MINT-8328405(identity)	-	-	-	comment:homomint|comment:mint|figure legend:t2 f1f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:CIkEOWd9OuFyigFJ02ORCqVbXHE9606	rogid:8xx/gaYzzVJ7p2xhvQrNv9Lpq6s559292	intact-crc:E9FA279944DEE09C|rigid:+d/2oIJm5r5vZ1+T8pqI91to1Ks	false	monoacetylated residue:274-274(MINT-8359818)|binding-associated region:174-458(MINT-8328408)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08649	uniprotkb:P02309	intact:EBI-6648|uniprotkb:D6W2U6|ensemblfungi:YOR244W	intact:EBI-8113|uniprotkb:D6VQ10|ensemblfungi:YBR009C|ensemblfungi:YNL030W	psi-mi:esa1_yeast(display_long)|uniprotkb:ESA1(gene name)|psi-mi:ESA1(display_short)|uniprotkb:O5257(orf name)|uniprotkb:YOR244W(locus name)	psi-mi:h4_yeast(display_long)|uniprotkb:N2752(orf name)|uniprotkb:YBR0122(orf name)|uniprotkb:YBR009C(locus name)|uniprotkb:YNL030W(locus name)|uniprotkb:HHF1(gene name)|psi-mi:HHF1(display_short)|uniprotkb:HHF2(gene name)|psi-mi:HHF2(display_short)	psi-mi:"MI:0415"(enzymatic study)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489542|mint:MINT-8328413|imex:IM-16687-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014887.3|sgd:S000005770|mint:Q08649|dip:DIP-4115N|ensemblfungi:YOR244W(gene)|ensemblfungi:YOR244W_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000785"(chromatin)|go:"GO:0001207"(obsolete histone displacement)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006354"(DNA-templated transcription, elongation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140068"(histone crotonyltransferase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR040706|rcsb pdb:1FY7|rcsb pdb:1MJ9|rcsb pdb:1MJA|rcsb pdb:1MJB|rcsb pdb:2RNZ|rcsb pdb:2RO0|rcsb pdb:3TO6|rcsb pdb:3TO7|rcsb pdb:3TO9|rcsb pdb:5J9Q|rcsb pdb:5J9T|rcsb pdb:5J9U|rcsb pdb:5J9W|reactome:R-SCE-9018519|mint:MINT-8328419(identity)	refseq:NP_009563.1|refseq:NP_014368.1|sgd:S000000213|sgd:S000004975|dip:DIP-418N|mint:P02309|ensemblfungi:YBR009C(gene)|ensemblfungi:YBR009C_mRNA(transcript)|ensemblfungi:YNL030W(gene)|ensemblfungi:YNL030W_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|interpro:IPR001951(Histone H4)|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1E6I|rcsb pdb:1ID3|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2E3K|rcsb pdb:2FSB|rcsb pdb:2H2H|rcsb pdb:2L5A|rcsb pdb:2QQF|rcsb pdb:2QQG|rcsb pdb:3TO6|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:4TWI|rcsb pdb:4TWJ|rcsb pdb:5W0V|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6QLD|rcsb pdb:6RXJ|rcsb pdb:6RXK|rcsb pdb:6RXL|rcsb pdb:6RXM|rcsb pdb:6RXO|rcsb pdb:6RXP|rcsb pdb:6RXQ|rcsb pdb:6RXR|rcsb pdb:7K78|rcsb pdb:7K7G|reactome:R-SCE-2299718|reactome:R-SCE-2559580|reactome:R-SCE-3214842|reactome:R-SCE-3214847|reactome:R-SCE-3214858|reactome:R-SCE-4551638|reactome:R-SCE-9018519|mint:MINT-8328415(identity)	-	crc64:9E970F744D0B9E18	crc64:69B7D1F89E62DE41	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:Zf0JVjFFEPhiL20FFOx2+dhO950559292	rogid:wGtUrumyxGKsW9BEzkBW3FwvwUo559292	intact-crc:024BD62EC36DE116|rigid:wn3y7NXc3Va7gSf5Q42sVAdt350	false	binding-associated region:160-435(MINT-8328420)|mutation disrupting interaction:262-262(MINT-8328433)	binding-associated region:2-22(MINT-8328416)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02309	uniprotkb:Q9H7Z6	intact:EBI-8113|uniprotkb:D6VQ10|ensemblfungi:YBR009C|ensemblfungi:YNL030W	intact:EBI-896414|uniprotkb:Q659G0|uniprotkb:Q7LC17|uniprotkb:Q8IY59|uniprotkb:Q8WYB4|uniprotkb:Q8WZ14|uniprotkb:Q9HAC5|uniprotkb:Q9NR35|uniprotkb:A8K4Z1|intact:EBI-2560822|uniprotkb:G5E9P2|ensembl:ENSP00000219797|ensembl:ENSP00000456933	psi-mi:h4_yeast(display_long)|uniprotkb:N2752(orf name)|uniprotkb:YBR0122(orf name)|uniprotkb:YBR009C(locus name)|uniprotkb:YNL030W(locus name)|uniprotkb:HHF1(gene name)|psi-mi:HHF1(display_short)|uniprotkb:HHF2(gene name)|psi-mi:HHF2(display_short)	psi-mi:kat8_human(display_long)|uniprotkb:KAT8(gene name)|psi-mi:KAT8(display_short)|uniprotkb:MOF(gene name synonym)|uniprotkb:PP7073(orf name)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1(gene name synonym)|uniprotkb:MYST1(gene name synonym)|uniprotkb:Lysine acetyltransferase 8(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489563|mint:MINT-8328437|imex:IM-16687-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009563.1|refseq:NP_014368.1|sgd:S000000213|sgd:S000004975|dip:DIP-418N|mint:P02309|ensemblfungi:YBR009C(gene)|ensemblfungi:YBR009C_mRNA(transcript)|ensemblfungi:YNL030W(gene)|ensemblfungi:YNL030W_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|interpro:IPR001951(Histone H4)|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1E6I|rcsb pdb:1ID3|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2E3K|rcsb pdb:2FSB|rcsb pdb:2H2H|rcsb pdb:2L5A|rcsb pdb:2QQF|rcsb pdb:2QQG|rcsb pdb:3TO6|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:4TWI|rcsb pdb:4TWJ|rcsb pdb:5W0V|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6QLD|rcsb pdb:6RXJ|rcsb pdb:6RXK|rcsb pdb:6RXL|rcsb pdb:6RXM|rcsb pdb:6RXO|rcsb pdb:6RXP|rcsb pdb:6RXQ|rcsb pdb:6RXR|rcsb pdb:7K78|rcsb pdb:7K7G|reactome:R-SCE-2299718|reactome:R-SCE-2559580|reactome:R-SCE-3214842|reactome:R-SCE-3214847|reactome:R-SCE-3214858|reactome:R-SCE-4551638|reactome:R-SCE-9018519|mint:MINT-8328439(identity)	refseq:NP_115564.2|refseq:NP_892003.2|ensembl:ENSG00000103510(gene)|ensembl:ENST00000219797(transcript)|ensembl:ENST00000543774(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000776"(kinetochore)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0043995"("histone acetyltransferase activity (H4-K5 specific)")|go:"GO:0043996"("histone acetyltransferase activity (H4-K8 specific)")|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046972"("histone acetyltransferase activity (H4-K16 specific)")|go:"GO:0071339"(MLL1 complex)|go:"GO:0072487"(MSL complex)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037906|interpro:IPR040706|mint:Q9H7Z6|rcsb pdb:2GIV|rcsb pdb:2PQ8|rcsb pdb:2Y0M|rcsb pdb:3QAH|rcsb pdb:3TOA|rcsb pdb:3TOB|rcsb pdb:4DNC|rcsb pdb:5H43|rcsb pdb:5J8C|rcsb pdb:5J8F|rcsb pdb:5WCI|rcsb pdb:6BA2|rcsb pdb:6BA4|rcsb pdb:6CT2|rcsb pdb:6OIN|rcsb pdb:6OIO|rcsb pdb:6OIP|rcsb pdb:6OIQ|rcsb pdb:6OIR|rcsb pdb:6OWH|rcsb pdb:6OWI|rcsb pdb:6PD8|rcsb pdb:6PD9|rcsb pdb:6PDA|rcsb pdb:6PDB|rcsb pdb:6PDC|rcsb pdb:6PDD|rcsb pdb:6PDE|rcsb pdb:6PDF|rcsb pdb:6PDG|rcsb pdb:7CMR|reactome:R-HSA-3214847|mint:MINT-8328443(identity)	-	crc64:69B7D1F89E62DE41	-	figure legend:f2b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:wGtUrumyxGKsW9BEzkBW3FwvwUo559292	rogid:CIkEOWd9OuFyigFJ02ORCqVbXHE9606	intact-crc:854FD52F26355C91|rigid:telcqLNZsnZ2wdnYnK2wx5wN8uY	false	binding-associated region:2-22(MINT-8328440)	binding-associated region:160-435(MINT-8328446)|mutation disrupting interaction:274-274(MINT-8328444)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08649	uniprotkb:P02309	intact:EBI-6648|uniprotkb:D6W2U6|ensemblfungi:YOR244W	intact:EBI-8113|uniprotkb:D6VQ10|ensemblfungi:YBR009C|ensemblfungi:YNL030W	psi-mi:esa1_yeast(display_long)|uniprotkb:ESA1(gene name)|psi-mi:ESA1(display_short)|uniprotkb:O5257(orf name)|uniprotkb:YOR244W(locus name)	psi-mi:h4_yeast(display_long)|uniprotkb:N2752(orf name)|uniprotkb:YBR0122(orf name)|uniprotkb:YBR009C(locus name)|uniprotkb:YNL030W(locus name)|uniprotkb:HHF1(gene name)|psi-mi:HHF1(display_short)|uniprotkb:HHF2(gene name)|psi-mi:HHF2(display_short)	psi-mi:"MI:0415"(enzymatic study)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489621|mint:MINT-8328468|imex:IM-16687-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_014887.3|sgd:S000005770|mint:Q08649|dip:DIP-4115N|ensemblfungi:YOR244W(gene)|ensemblfungi:YOR244W_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000785"(chromatin)|go:"GO:0001207"(obsolete histone displacement)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006354"(DNA-templated transcription, elongation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140068"(histone crotonyltransferase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR040706|rcsb pdb:1FY7|rcsb pdb:1MJ9|rcsb pdb:1MJA|rcsb pdb:1MJB|rcsb pdb:2RNZ|rcsb pdb:2RO0|rcsb pdb:3TO6|rcsb pdb:3TO7|rcsb pdb:3TO9|rcsb pdb:5J9Q|rcsb pdb:5J9T|rcsb pdb:5J9U|rcsb pdb:5J9W|reactome:R-SCE-9018519|mint:MINT-8328474(identity)	refseq:NP_009563.1|refseq:NP_014368.1|sgd:S000000213|sgd:S000004975|dip:DIP-418N|mint:P02309|ensemblfungi:YBR009C(gene)|ensemblfungi:YBR009C_mRNA(transcript)|ensemblfungi:YNL030W(gene)|ensemblfungi:YNL030W_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|interpro:IPR001951(Histone H4)|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1E6I|rcsb pdb:1ID3|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2E3K|rcsb pdb:2FSB|rcsb pdb:2H2H|rcsb pdb:2L5A|rcsb pdb:2QQF|rcsb pdb:2QQG|rcsb pdb:3TO6|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:4TWI|rcsb pdb:4TWJ|rcsb pdb:5W0V|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6QLD|rcsb pdb:6RXJ|rcsb pdb:6RXK|rcsb pdb:6RXL|rcsb pdb:6RXM|rcsb pdb:6RXO|rcsb pdb:6RXP|rcsb pdb:6RXQ|rcsb pdb:6RXR|rcsb pdb:7K78|rcsb pdb:7K7G|reactome:R-SCE-2299718|reactome:R-SCE-2559580|reactome:R-SCE-3214842|reactome:R-SCE-3214847|reactome:R-SCE-3214858|reactome:R-SCE-4551638|reactome:R-SCE-9018519|mint:MINT-8328470(identity)	-	crc64:9E970F744D0B9E18	crc64:69B7D1F89E62DE41	figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:Zf0JVjFFEPhiL20FFOx2+dhO950559292	rogid:wGtUrumyxGKsW9BEzkBW3FwvwUo559292	intact-crc:6005667E4FABB830|rigid:wn3y7NXc3Va7gSf5Q42sVAdt350	false	mutation decreasing interaction:262-262(MINT-8328477)|binding-associated region:160-435(MINT-8328475)	binding-associated region:2-22(MINT-8328471)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02309	uniprotkb:Q08649	intact:EBI-8113|uniprotkb:D6VQ10|ensemblfungi:YBR009C|ensemblfungi:YNL030W	intact:EBI-6648|uniprotkb:D6W2U6|ensemblfungi:YOR244W	psi-mi:h4_yeast(display_long)|uniprotkb:N2752(orf name)|uniprotkb:YBR0122(orf name)|uniprotkb:YBR009C(locus name)|uniprotkb:YNL030W(locus name)|uniprotkb:HHF1(gene name)|psi-mi:HHF1(display_short)|uniprotkb:HHF2(gene name)|psi-mi:HHF2(display_short)	psi-mi:esa1_yeast(display_long)|uniprotkb:ESA1(gene name)|psi-mi:ESA1(display_short)|uniprotkb:O5257(orf name)|uniprotkb:YOR244W(locus name)	psi-mi:"MI:0415"(enzymatic study)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489584|mint:MINT-8328452|imex:IM-16687-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009563.1|refseq:NP_014368.1|sgd:S000000213|sgd:S000004975|dip:DIP-418N|mint:P02309|ensemblfungi:YBR009C(gene)|ensemblfungi:YBR009C_mRNA(transcript)|ensemblfungi:YNL030W(gene)|ensemblfungi:YNL030W_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|interpro:IPR001951(Histone H4)|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1E6I|rcsb pdb:1ID3|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2E3K|rcsb pdb:2FSB|rcsb pdb:2H2H|rcsb pdb:2L5A|rcsb pdb:2QQF|rcsb pdb:2QQG|rcsb pdb:3TO6|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:4TWI|rcsb pdb:4TWJ|rcsb pdb:5W0V|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6QLD|rcsb pdb:6RXJ|rcsb pdb:6RXK|rcsb pdb:6RXL|rcsb pdb:6RXM|rcsb pdb:6RXO|rcsb pdb:6RXP|rcsb pdb:6RXQ|rcsb pdb:6RXR|rcsb pdb:7K78|rcsb pdb:7K7G|reactome:R-SCE-2299718|reactome:R-SCE-2559580|reactome:R-SCE-3214842|reactome:R-SCE-3214847|reactome:R-SCE-3214858|reactome:R-SCE-4551638|reactome:R-SCE-9018519|mint:MINT-8328454(identity)	refseq:NP_014887.3|sgd:S000005770|mint:Q08649|dip:DIP-4115N|ensemblfungi:YOR244W(gene)|ensemblfungi:YOR244W_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000785"(chromatin)|go:"GO:0001207"(obsolete histone displacement)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006354"(DNA-templated transcription, elongation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016573"(histone acetylation)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0032777"(Piccolo NuA4 histone acetyltransferase complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034212"(peptide N-acetyltransferase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0140068"(histone crotonyltransferase activity)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR040706|rcsb pdb:1FY7|rcsb pdb:1MJ9|rcsb pdb:1MJA|rcsb pdb:1MJB|rcsb pdb:2RNZ|rcsb pdb:2RO0|rcsb pdb:3TO6|rcsb pdb:3TO7|rcsb pdb:3TO9|rcsb pdb:5J9Q|rcsb pdb:5J9T|rcsb pdb:5J9U|rcsb pdb:5J9W|reactome:R-SCE-9018519|mint:MINT-8328458(identity)	-	crc64:69B7D1F89E62DE41	crc64:9E970F744D0B9E18	figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:wGtUrumyxGKsW9BEzkBW3FwvwUo559292	rogid:Zf0JVjFFEPhiL20FFOx2+dhO950559292	intact-crc:D67F7370771302A9|rigid:wn3y7NXc3Va7gSf5Q42sVAdt350	false	binding-associated region:2-22(MINT-8328455)	binding-associated region:160-435(MINT-8328461)|mutation disrupting interaction:262-262(MINT-8328459)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H7Z6	uniprotkb:P02309	intact:EBI-896414|uniprotkb:Q659G0|uniprotkb:Q7LC17|uniprotkb:Q8IY59|uniprotkb:Q8WYB4|uniprotkb:Q8WZ14|uniprotkb:Q9HAC5|uniprotkb:Q9NR35|uniprotkb:A8K4Z1|intact:EBI-2560822|uniprotkb:G5E9P2|ensembl:ENSP00000219797|ensembl:ENSP00000456933	intact:EBI-8113|uniprotkb:D6VQ10|ensemblfungi:YBR009C|ensemblfungi:YNL030W	psi-mi:kat8_human(display_long)|uniprotkb:KAT8(gene name)|psi-mi:KAT8(display_short)|uniprotkb:MOF(gene name synonym)|uniprotkb:PP7073(orf name)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1(gene name synonym)|uniprotkb:MYST1(gene name synonym)|uniprotkb:Lysine acetyltransferase 8(gene name synonym)	psi-mi:h4_yeast(display_long)|uniprotkb:N2752(orf name)|uniprotkb:YBR0122(orf name)|uniprotkb:YBR009C(locus name)|uniprotkb:YNL030W(locus name)|uniprotkb:HHF1(gene name)|psi-mi:HHF1(display_short)|uniprotkb:HHF2(gene name)|psi-mi:HHF2(display_short)	psi-mi:"MI:0415"(enzymatic study)	Yuan et al. (2012)	doi:10.1038/emboj.2011.382|pubmed:22020126|imex:IM-16687|mint:MINT-8328134	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0192"(acetylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7489642|mint:MINT-8328483|imex:IM-16687-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115564.2|refseq:NP_892003.2|ensembl:ENSG00000103510(gene)|ensembl:ENST00000219797(transcript)|ensembl:ENST00000543774(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000776"(kinetochore)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0043995"("histone acetyltransferase activity (H4-K5 specific)")|go:"GO:0043996"("histone acetyltransferase activity (H4-K8 specific)")|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046972"("histone acetyltransferase activity (H4-K16 specific)")|go:"GO:0071339"(MLL1 complex)|go:"GO:0072487"(MSL complex)|interpro:IPR000953(Chromo domain)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR036388|interpro:IPR037906|interpro:IPR040706|mint:Q9H7Z6|rcsb pdb:2GIV|rcsb pdb:2PQ8|rcsb pdb:2Y0M|rcsb pdb:3QAH|rcsb pdb:3TOA|rcsb pdb:3TOB|rcsb pdb:4DNC|rcsb pdb:5H43|rcsb pdb:5J8C|rcsb pdb:5J8F|rcsb pdb:5WCI|rcsb pdb:6BA2|rcsb pdb:6BA4|rcsb pdb:6CT2|rcsb pdb:6OIN|rcsb pdb:6OIO|rcsb pdb:6OIP|rcsb pdb:6OIQ|rcsb pdb:6OIR|rcsb pdb:6OWH|rcsb pdb:6OWI|rcsb pdb:6PD8|rcsb pdb:6PD9|rcsb pdb:6PDA|rcsb pdb:6PDB|rcsb pdb:6PDC|rcsb pdb:6PDD|rcsb pdb:6PDE|rcsb pdb:6PDF|rcsb pdb:6PDG|rcsb pdb:7CMR|reactome:R-HSA-3214847|mint:MINT-8328489(identity)	refseq:NP_009563.1|refseq:NP_014368.1|sgd:S000000213|sgd:S000004975|dip:DIP-418N|mint:P02309|ensemblfungi:YBR009C(gene)|ensemblfungi:YBR009C_mRNA(transcript)|ensemblfungi:YNL030W(gene)|ensemblfungi:YNL030W_mRNA(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0034729"(histone H3-K79 methylation)|go:"GO:0043935"(sexual sporulation resulting in formation of a cellular spore)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061587"(transfer RNA gene-mediated silencing)|interpro:IPR001951(Histone H4)|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|rcsb pdb:1E6I|rcsb pdb:1ID3|rcsb pdb:1Q1A|rcsb pdb:1SZC|rcsb pdb:1SZD|rcsb pdb:2DVQ|rcsb pdb:2DVR|rcsb pdb:2E3K|rcsb pdb:2FSB|rcsb pdb:2H2H|rcsb pdb:2L5A|rcsb pdb:2QQF|rcsb pdb:2QQG|rcsb pdb:3TO6|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4PSX|rcsb pdb:4TWI|rcsb pdb:4TWJ|rcsb pdb:5W0V|rcsb pdb:5ZBA|rcsb pdb:5ZBB|rcsb pdb:6GEJ|rcsb pdb:6GEN|rcsb pdb:6QLD|rcsb pdb:6RXJ|rcsb pdb:6RXK|rcsb pdb:6RXL|rcsb pdb:6RXM|rcsb pdb:6RXO|rcsb pdb:6RXP|rcsb pdb:6RXQ|rcsb pdb:6RXR|rcsb pdb:7K78|rcsb pdb:7K7G|reactome:R-SCE-2299718|reactome:R-SCE-2559580|reactome:R-SCE-3214842|reactome:R-SCE-3214847|reactome:R-SCE-3214858|reactome:R-SCE-4551638|reactome:R-SCE-9018519|mint:MINT-8328485(identity)	-	-	crc64:69B7D1F89E62DE41	figure legend:sf3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/02/23	2014/10/16	rogid:CIkEOWd9OuFyigFJ02ORCqVbXHE9606	rogid:wGtUrumyxGKsW9BEzkBW3FwvwUo559292	intact-crc:988E652F26351884|rigid:telcqLNZsnZ2wdnYnK2wx5wN8uY	false	binding-associated region:160-435(MINT-8328490)|mutation disrupting interaction:274-274(MINT-8328492)	binding-associated region:2-22(MINT-8328486)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)