#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99JP0	uniprotkb:Q02111	intact:EBI-5324222|ensembl:ENSMUSP00000025089|uniprotkb:E9PWI4|uniprotkb:Q9CUS8	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:m4k3_mouse(display_long)|uniprotkb:Map4k3(gene name)|psi-mi:Map4k3(display_short)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324221|imex:IM-16889-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024242(gene)|ensembl:ENSMUST00000025089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|go:"GO:0034612"(response to tumor necrosis factor)|refseq:NP_001277274.1	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	-	-	-	figure legend:Fig. 1B|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2012/01/08	2014/10/16	rogid:+UiBTN9B0UzbaIFK8Qz8/NzawIA10090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:94243EE60E11FFFE|rigid:TZqYeEraC5YueOlEJv1bLcBPC/Y	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99JP0	uniprotkb:Q02111	intact:EBI-5324222|ensembl:ENSMUSP00000025089|uniprotkb:E9PWI4|uniprotkb:Q9CUS8	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:m4k3_mouse(display_long)|uniprotkb:Map4k3(gene name)|psi-mi:Map4k3(display_short)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324269|imex:IM-16889-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024242(gene)|ensembl:ENSMUST00000025089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|go:"GO:0034612"(response to tumor necrosis factor)|refseq:NP_001277274.1	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	-	-	-	figure legend:Fig. 2A|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2012/01/08	2014/10/16	rogid:+UiBTN9B0UzbaIFK8Qz8/NzawIA10090	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:69636575C2423FEB|rigid:90AWf2v8yG0ORg66Wtl4qx/jPEk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99JP0	uniprotkb:Q60787	intact:EBI-5324222|ensembl:ENSMUSP00000025089|uniprotkb:E9PWI4|uniprotkb:Q9CUS8	intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0	psi-mi:m4k3_mouse(display_long)|uniprotkb:Map4k3(gene name)|psi-mi:Map4k3(display_short)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)	psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324269|imex:IM-16889-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024242(gene)|ensembl:ENSMUST00000025089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|go:"GO:0034612"(response to tumor necrosis factor)|refseq:NP_001277274.1	ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2	-	-	-	figure legend:Fig. 2A|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2012/01/08	2014/10/16	rogid:+UiBTN9B0UzbaIFK8Qz8/NzawIA10090	rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090	intact-crc:69636575C2423FEB|rigid:90AWf2v8yG0ORg66Wtl4qx/jPEk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IVH8	-	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	-	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324285|imex:IM-16889-17	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	go:"GO:0046777"(protein autophosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. S2C|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	-	intact-crc:5345F7A918A62A2E	false	flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q8IVH8	uniprotkb:Q02111	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591171|imex:IM-16889-10	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:8D6A0D3867C21CE6|rigid:U4FfDQt6TkfklXa2fZWMhqJZjzc	false	flag tag:?-?	myc tag:?-?|phosphorus containing modified residue:538-538	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04759	uniprotkb:Q8IVH8	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324307|imex:IM-16889-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. S3B|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-j-tag)|taxid:9606(Homo sapiens T cell)	-	2012/01/08	2014/10/16	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:306823D9ABF92CDB|rigid:3DUDxYC7Cb8xodZvW5msGvFHIww	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IVH8	uniprotkb:Q04759	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324315|imex:IM-16889-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	-	-	-	figure legend:Fig. S4C|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-j-tag)|taxid:9606(Homo sapiens T cell)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	intact-crc:D3D38C012E3F76DD|rigid:H7clQIwL/B6Tf631JDFdZXtvrZI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IVH8	uniprotkb:Q13094	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324315|imex:IM-16889-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	-	-	-	figure legend:Fig. S4C|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-j-tag)|taxid:9606(Homo sapiens T cell)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	intact-crc:D3D38C012E3F76DD|rigid:H7clQIwL/B6Tf631JDFdZXtvrZI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13094	uniprotkb:Q8IVH8	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591216|imex:IM-16889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. S4B|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-j-tag)|taxid:9606(Homo sapiens T cell)	-	2012/01/08	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:D1A6FF145670AF5C|rigid:H7clQIwL/B6Tf631JDFdZXtvrZI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13094	uniprotkb:Q04759	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591216|imex:IM-16889-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	-	-	-	figure legend:Fig. S4B|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-j-tag)|taxid:9606(Homo sapiens T cell)	-	2012/01/08	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	intact-crc:D1A6FF145670AF5C|rigid:H7clQIwL/B6Tf631JDFdZXtvrZI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IVH8	uniprotkb:Q60787	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-5324248|ensembl:ENSMUSP00000056621|uniprotkb:Q922M0	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:lcp2_mouse(display_long)|uniprotkb:Lcp2(gene name)|psi-mi:Lcp2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324333|imex:IM-16889-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	ensembl:ENSMUSG00000002699(gene)|ensembl:ENSMUST00000052413(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0045576"(mast cell activation)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|rcsb pdb:1OEB|rcsb pdb:2ETZ|rcsb pdb:2EU0|reactome:R-MMU-114604|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|refseq:NP_034826.2	-	-	-	figure legend:Fig. S3C|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-el4)|taxid:10090(Mus musculus)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:cPQxtVXOgp/RmfnY+w9OMnjRztM10090	intact-crc:F49068881C96F9EE|rigid:mnNS4fJE1KjFOz140xvq7InwYIM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IVH8	uniprotkb:Q02111	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324333|imex:IM-16889-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	-	-	-	figure legend:Fig. S3C|agonist:anti-CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-el4)|taxid:10090(Mus musculus)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:F49068881C96F9EE|rigid:mnNS4fJE1KjFOz140xvq7InwYIM	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13094	uniprotkb:Q8IVH8	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591096|imex:IM-16889-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/08	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:AAF859ACAC4BFE0D|rigid:DDt7SZyMMCxyEg3/2lYvdezHQH8	false	flag tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IVH8	uniprotkb:Q13094	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591104|imex:IM-16889-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	intact-crc:3332ED0788A118A7|rigid:DDt7SZyMMCxyEg3/2lYvdezHQH8	false	flag tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04759	uniprotkb:Q8IVH8	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591147|imex:IM-16889-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/08	2014/10/16	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:2EA9A34F2DF7AA30|rigid:3DUDxYC7Cb8xodZvW5msGvFHIww	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IVH8	uniprotkb:Q04759	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591130|imex:IM-16889-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	intact-crc:6BAA42B675091A58|rigid:3DUDxYC7Cb8xodZvW5msGvFHIww	false	flag tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IVH8	uniprotkb:Q02111	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	intact:EBI-2639157|ensembl:ENSMUSP00000028118	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591200|imex:IM-16889-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	-	-	-	figure legend:Fig. S3.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/08	2014/10/16	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	intact-crc:29818966269D43CB|rigid:U4FfDQt6TkfklXa2fZWMhqJZjzc	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q02111	uniprotkb:Q8IVH8	intact:EBI-2639157|ensembl:ENSMUSP00000028118	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:kpct_mouse(display_long)|uniprotkb:Prkcq(gene name)|psi-mi:Prkcq(display_short)|uniprotkb:Pkcq(gene name synonym)|uniprotkb:nPKC-theta(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591208|imex:IM-16889-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032885.1|reactome:R-MMU-373752|reactome:R-MMU-9648002|ensembl:ENSMUSG00000026778(gene)|ensembl:ENSMUST00000028118(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042383"(sarcolemma)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|rcsb pdb:4FKD|reactome:R-MMU-111465|reactome:R-MMU-114508|reactome:R-MMU-202424|reactome:R-MMU-2871837|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-55947N	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. S3A.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/08	2014/10/16	rogid:3Z5IAK4st0h66ZfvvqJuzUvwCQM10090	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:1FCA27CA78422772|rigid:U4FfDQt6TkfklXa2fZWMhqJZjzc	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13094	uniprotkb:Q99JP0	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-5324222|ensembl:ENSMUSP00000025089|uniprotkb:E9PWI4|uniprotkb:Q9CUS8	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:m4k3_mouse(display_long)|uniprotkb:Map4k3(gene name)|psi-mi:Map4k3(display_short)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591239|imex:IM-16889-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	ensembl:ENSMUSG00000024242(gene)|ensembl:ENSMUST00000025089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|go:"GO:0034612"(response to tumor necrosis factor)|refseq:NP_001277274.1	-	-	-	figure legend:Fig. S4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/08	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:+UiBTN9B0UzbaIFK8Qz8/NzawIA10090	intact-crc:F4A687E4A23BBFCE|rigid:VqHInct7CptdutLzJAXLTcrscOc	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13094	uniprotkb:Q99JP0	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-5324222|ensembl:ENSMUSP00000025089|uniprotkb:E9PWI4|uniprotkb:Q9CUS8	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:m4k3_mouse(display_long)|uniprotkb:Map4k3(gene name)|psi-mi:Map4k3(display_short)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591233|imex:IM-16889-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	ensembl:ENSMUSG00000024242(gene)|ensembl:ENSMUST00000025089(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|go:"GO:0034612"(response to tumor necrosis factor)|refseq:NP_001277274.1	-	-	-	figure legend:Fig. S4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/08	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:+UiBTN9B0UzbaIFK8Qz8/NzawIA10090	intact-crc:25684F76B213F3CA|rigid:VqHInct7CptdutLzJAXLTcrscOc	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13094	uniprotkb:Q8IVH8	intact:EBI-346946|uniprotkb:Q53XV4|uniprotkb:A8KA25|ensembl:ENSP00000046794	intact:EBI-1758170|uniprotkb:Q8IVH7|uniprotkb:Q9UDM5|uniprotkb:Q9Y6R5|uniprotkb:Q6IQ39|ensembl:ENSP00000263881	psi-mi:lcp2_human(display_long)|uniprotkb:LCP2(gene name)|psi-mi:LCP2(display_short)|uniprotkb:SH2 domain-containing leukocyte protein of 76 kDa(gene name synonym)|uniprotkb:SLP-76 tyrosine phosphoprotein(gene name synonym)	psi-mi:m4k3_human(display_long)|uniprotkb:MAP4K3(gene name)|psi-mi:MAP4K3(display_short)|uniprotkb:RAB8IPL1(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 3(gene name synonym)|uniprotkb:Germinal center kinase-related protein kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chuang et al. (2011)	pubmed:21983831|imex:IM-16889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5591249|imex:IM-16889-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005556.1|dip:DIP-31812N|ensembl:ENSG00000043462(gene)|ensembl:ENST00000046794(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036398"(TCR signalosome)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045576"(mast cell activation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR036860|mint:Q13094|rcsb pdb:1H3H|rcsb pdb:1YWO|rcsb pdb:2EAP|rcsb pdb:2ROR|rcsb pdb:6ZCJ|reactome:R-HSA-114604|reactome:R-HSA-202433|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809	refseq:NP_003609.2|refseq:NP_001257354.1|dip:DIP-48924N|ensembl:ENSG00000011566(gene)|ensembl:ENST00000263881(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0009411"(response to UV)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR021160|rcsb pdb:5J5T	-	-	-	figure legend:Fig. S4D|agonist:pervanadate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/08	2014/10/16	rogid:lZa+nAuqvGDrNe3Jhxn/JQaU5ug9606	rogid:8/9c0mrkfMgStocGbtU9s4BLXfQ9606	intact-crc:8C1D395CEE714670|rigid:DDt7SZyMMCxyEg3/2lYvdezHQH8	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)