#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P98164	uniprotkb:Q01968	intact:EBI-947916|uniprotkb:O00711|uniprotkb:Q16215|ensembl:ENSP00000496870	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:lrp2_human(display_long)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:LRP2(gene name)|psi-mi:LRP2(display_short)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Vicinanza et al. (2011)	doi:10.1038/emboj.2011.354|pubmed:21971085|imex:IM-17557|mint:MINT-8306957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7461776|mint:MINT-8306967|imex:IM-17557-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004516.2|ensembl:ENSG00000081479(gene)|ensembl:ENST00000649046(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030001"(metal ion transport)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0035904"(aorta development)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045056"(transcytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140318"(protein transporter activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904447"(folate import across plasma membrane)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR019825|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|rcsb pdb:2M0P|reactome:R-HSA-196791|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-975634|mint:MINT-8306970(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-8306969(identity)	go:"GO:0005768"(endosome)	-	-	figure legend:f1a f1b|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hk2)|taxid:9606(Homo sapiens)	-	2012/01/31	2014/10/16	rogid:JDlI4t/EC/jeCde5RYJqidr4lfg9606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:242C32F8EFCC6E3C|rigid:K+Zxmn9+2jmUNVOp1HQDCuQptc8	false	ha tag:?-?(MINT-8306976)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q15075	uniprotkb:P98164	intact:EBI-298113|uniprotkb:Q14221|ensembl:ENSP00000317955	intact:EBI-947916|uniprotkb:O00711|uniprotkb:Q16215|ensembl:ENSP00000496870	psi-mi:eea1_human(display_long)|uniprotkb:EEA1(gene name)|psi-mi:EEA1(display_short)|uniprotkb:ZFYVE2(gene name synonym)|uniprotkb:Endosome-associated protein p162(gene name synonym)|uniprotkb:Zinc finger FYVE domain-containing protein 2(gene name synonym)	psi-mi:lrp2_human(display_long)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:LRP2(gene name)|psi-mi:LRP2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Vicinanza et al. (2011)	doi:10.1038/emboj.2011.354|pubmed:21971085|imex:IM-17557|mint:MINT-8306957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7461794|mint:MINT-8306982|imex:IM-17557-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102189(gene)|ensembl:ENST00000322349(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q15075|rcsb pdb:1HYI|rcsb pdb:1HYJ|rcsb pdb:1JOC|rcsb pdb:3MJH|reactome:R-HSA-168138|refseq:NP_003557.2|mint:MINT-8306985(identity)	refseq:NP_004516.2|ensembl:ENSG00000081479(gene)|ensembl:ENST00000649046(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030001"(metal ion transport)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0035904"(aorta development)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045056"(transcytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140318"(protein transporter activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904447"(folate import across plasma membrane)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR019825|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|rcsb pdb:2M0P|reactome:R-HSA-196791|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-975634|mint:MINT-8306987(identity)	go:"GO:0005768"(endosome)	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hk2)|taxid:9606(Homo sapiens)	-	2012/01/31	2014/10/16	rogid:aKGquyBsTFm+hhbJiIbz1Lv88Hw9606	rogid:JDlI4t/EC/jeCde5RYJqidr4lfg9606	intact-crc:110C88E5E436F658|rigid:Lmm4/lZbe9bpR1KeXfCExIJZzTQ	false	-	ha tag:?-?(MINT-8306988)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P20645	uniprotkb:P98164	intact:EBI-2907262|ensembl:ENSP00000000412|uniprotkb:A8K528|uniprotkb:D3DUV5	intact:EBI-947916|uniprotkb:O00711|uniprotkb:Q16215|ensembl:ENSP00000496870	psi-mi:mprd_human(display_long)|uniprotkb:M6PR(gene name)|psi-mi:M6PR(display_short)|uniprotkb:MPR46(gene name synonym)|uniprotkb:MPRD(gene name synonym)|uniprotkb:46 kDa mannose 6-phosphate receptor(gene name synonym)	psi-mi:lrp2_human(display_long)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:LRP2(gene name)|psi-mi:LRP2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Vicinanza et al. (2011)	doi:10.1038/emboj.2011.354|pubmed:21971085|imex:IM-17557|mint:MINT-8306957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7461830|mint:MINT-8307007|imex:IM-17557-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000003056(gene)|ensembl:ENST00000000412(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030133"(transport vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0033299"(secretion of lysosomal enzymes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000296(Cation-dependent mannose-6-phosphate receptor)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR028927|interpro:IPR044865|mint:P20645|rcsb pdb:1JUQ|reactome:R-HSA-432720|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|refseq:NP_002346.1|refseq:XP_005253433.1|mint:MINT-8307014(identity)	refseq:NP_004516.2|ensembl:ENSG00000081479(gene)|ensembl:ENST00000649046(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030001"(metal ion transport)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0035904"(aorta development)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045056"(transcytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140318"(protein transporter activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904447"(folate import across plasma membrane)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR019825|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|rcsb pdb:2M0P|reactome:R-HSA-196791|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-975634|mint:MINT-8307010(identity)	go:"GO:0005768"(endosome)	-	-	comment:homomint|comment:mint|figure legend:Sf1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hk2)|taxid:9606(Homo sapiens)	-	2012/01/31	2014/10/16	rogid:Nx1pgku9M1SjHH42s5ZAY7c7eDc9606	rogid:JDlI4t/EC/jeCde5RYJqidr4lfg9606	intact-crc:2A5CAB27BA5B9037|rigid:/kEGPRGQuVPV5DM+k2oDyxvehGI	false	-	ha tag:?-?(MINT-8307011)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q9UKG1	uniprotkb:P98164	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-947916|uniprotkb:O00711|uniprotkb:Q16215|ensembl:ENSP00000496870	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:lrp2_human(display_long)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym)|uniprotkb:LRP2(gene name)|psi-mi:LRP2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Vicinanza et al. (2011)	doi:10.1038/emboj.2011.354|pubmed:21971085|imex:IM-17557|mint:MINT-8306957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7461812|mint:MINT-8306996|imex:IM-17557-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N|mint:MINT-8307003(identity)	refseq:NP_004516.2|ensembl:ENSG00000081479(gene)|ensembl:ENST00000649046(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030001"(metal ion transport)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0035904"(aorta development)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044321"(response to leptin)|go:"GO:0045056"(transcytosis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140318"(protein transporter activity)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904447"(folate import across plasma membrane)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR019825|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|rcsb pdb:2M0P|reactome:R-HSA-196791|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-975634|mint:MINT-8306999(identity)	go:"GO:0005768"(endosome)	-	-	figure legend:f1c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hk2)|taxid:9606(Homo sapiens)	-	2012/01/31	2014/10/16	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:JDlI4t/EC/jeCde5RYJqidr4lfg9606	intact-crc:F583FDF1C1C51B14|rigid:Lh4WYnbq4HZ6GaPirhz0+E3RmQ0	false	-	ha tag:?-?(MINT-8307000)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q92805	uniprotkb:Q01968	intact:EBI-6164177|ensembl:ENSP00000362656|uniprotkb:Q5T164|uniprotkb:Q8IYZ9	intact:EBI-6148898|uniprotkb:O60800|uniprotkb:Q15684|uniprotkb:A6NKI1|uniprotkb:Q9UMA5|uniprotkb:Q4VY09|uniprotkb:Q5JQF2|uniprotkb:A8KAP2|uniprotkb:Q15774|uniprotkb:Q5JQF1|uniprotkb:Q9UJG5|uniprotkb:Q4VY10|uniprotkb:B7ZLX2|ensembl:ENSP00000360154	psi-mi:goga1_human(display_long)|uniprotkb:GOLGA1(gene name)|psi-mi:GOLGA1(display_short)|uniprotkb:Golgin-97(gene name synonym)	psi-mi:ocrl_human(display_long)|uniprotkb:Inositol polyphosphate 5-phosphatase OCRL-1(gene name synonym)|uniprotkb:Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase(gene name synonym)|uniprotkb:OCRL(gene name)|psi-mi:OCRL(display_short)|uniprotkb:Lowe oculocerebrorenal syndrome protein(gene name synonym)|uniprotkb:OCRL1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Vicinanza et al. (2011)	doi:10.1038/emboj.2011.354|pubmed:21971085|imex:IM-17557|mint:MINT-8306957	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7461872|mint:MINT-8307031|imex:IM-17557-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136935(gene)|ensembl:ENST00000373555(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000237(GRIP)|reactome:R-HSA-6811440|refseq:NP_002068.1|refseq:XP_006717125.1|refseq:XP_006717126.1|refseq:XP_005251986.1|mint:MINT-8307038(identity)	refseq:NP_000267.2|refseq:NP_001578.2|dip:DIP-45092N|ensembl:ENSG00000122126(gene)|ensembl:ENST00000371113(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0034596"(phosphatidylinositol phosphate 4-phosphatase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0043813"(phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|go:"GO:0052745"(inositol phosphate phosphatase activity)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|interpro:IPR000198(RhoGAP)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR031995|interpro:IPR036691|interpro:IPR037787|interpro:IPR037793|mint:Q01968|rcsb pdb:2KIE|rcsb pdb:2QV2|rcsb pdb:3QBT|rcsb pdb:3QIS|rcsb pdb:4CMN|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1855183|reactome:R-HSA-1855204|reactome:R-HSA-432722|reactome:R-HSA-8856828|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-8307034(identity)	go:"GO:0005794"(Golgi apparatus)	-	-	comment:homomint|comment:mint|figure legend:Sf2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ptc)|taxid:9606(Homo sapiens)	-	2012/01/31	2014/10/16	rogid:5SRVVvNxZ7PikOK9zV4HypxK8i49606	rogid:vbBQzhjgvm07+wOJkWgz+dyEBI49606	intact-crc:28A5B9BAB32F2720|rigid:pyUp3U7vDU/qfH2E5+BTL3L3Ytg	false	-	green fluorescent protein tag:?-?(MINT-8307035)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)