#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q04759	uniprotkb:P31041	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	intact:EBI-5323998|ensembl:ENSMUSP00000027165|uniprotkb:Q6GSH7	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:cd28_mouse(display_long)|uniprotkb:Cd28(gene name)|psi-mi:Cd28(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kong et al. (2011)	pubmed:21964608|imex:IM-18122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324012|imex:IM-18122-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	ensembl:ENSMUSG00000026012(gene)|ensembl:ENSMUST00000027165(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0002020"(protease binding)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0045121"(membrane raft)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR008093(T cell antigen CD28)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:2NAE|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-6811558|refseq:NP_031668.3|dip:DIP-60858N	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2012/01/04	2014/10/16	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	rogid:DT/rBn4RC67LtoEWo40+H2Wch1Q10090	intact-crc:CD80D544F2664504|rigid:0EqHN6A0xA57iOq38yl7kmNt/n8	false	myc tag:n-n|sufficient binding region:282-379	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q04759	uniprotkb:P06239	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2011)	pubmed:21964608|imex:IM-18122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6389823|imex:IM-18122-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	-	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2012/01/04	2014/10/16	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:E564086CB20A6EF5|rigid:Mc39BpQfJGpR6aj/W4AXskGvfDQ	false	sufficient binding region:282-379|myc tag:n-n	mutation disrupting interaction:154-154	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04759	uniprotkb:P10747	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	intact:EBI-4314301|uniprotkb:Q8WXJ2|uniprotkb:Q52M23|uniprotkb:A8KAC1|uniprotkb:Q8NI56|uniprotkb:Q9BYV0|uniprotkb:Q8NI54|uniprotkb:Q8NI55|uniprotkb:Q13964|uniprotkb:Q70WG0|ensembl:ENSP00000324890	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:cd28_human(display_long)|uniprotkb:CD28(gene name)|psi-mi:CD28(display_short)|uniprotkb:TP44(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2011)	pubmed:21964608|imex:IM-18122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324031|imex:IM-18122-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	refseq:NP_001230006.1|refseq:NP_001230007.1|refseq:NP_006130.1|refseq:XP_011510496.1|refseq:XP_011510499.1|ensembl:ENSG00000178562(gene)|ensembl:ENST00000324106(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002020"(protease binding)|go:"GO:0002863"(positive regulation of inflammatory response to antigenic stimulus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006959"(humoral immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045066"(regulatory T cell differentiation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR008093(T cell antigen CD28)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040216|rcsb pdb:1YJD|rcsb pdb:3WA4|rcsb pdb:5AUL|rcsb pdb:5GJH|rcsb pdb:5GJI|rcsb pdb:6O8D|reactome:R-HSA-1257604|reactome:R-HSA-164939|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-6811558|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0050852"(T cell receptor signaling pathway)|dip:DIP-6043N	-	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2012/01/04	2014/10/16	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	rogid:hXXImyYy1G/3xoStJWpisi3sIWI9606	intact-crc:55531FF770872632|rigid:52fnqRMjtGXG21Q8t30ejYnNvZo	false	sufficient binding region:282-379|myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q04759	uniprotkb:P06239	intact:EBI-374762|uniprotkb:Q14DH6|uniprotkb:Q3MJF1|uniprotkb:Q64FY5|uniprotkb:Q9H508|uniprotkb:Q9H549|ensembl:ENSP00000263125|uniprotkb:B4DF52	intact:EBI-1348|uniprotkb:P07100|uniprotkb:Q12850|uniprotkb:Q13152|uniprotkb:Q5TDH8|uniprotkb:Q5TDH9|uniprotkb:Q96DW4|uniprotkb:Q9NYT8|ensembl:ENSP00000337825|ensembl:ENSP00000477713|uniprotkb:Q7RTZ3|uniprotkb:D3DPP8	psi-mi:kpct_human(display_long)|uniprotkb:PRKCQ(gene name)|psi-mi:PRKCQ(display_short)|uniprotkb:nPKC-theta(gene name synonym)|uniprotkb:PRKCT(gene name synonym)	psi-mi:lck_human(display_long)|uniprotkb:Protein YT16(gene name synonym)|uniprotkb:Proto-oncogene Lck(gene name synonym)|uniprotkb:T cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:LCK(gene name)|psi-mi:LCK(display_short)|uniprotkb:Lymphocyte cell-specific protein-tyrosine kinase(gene name synonym)|uniprotkb:p56-LCK(gene name synonym)|uniprotkb:Leukocyte C-terminal Src kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kong et al. (2011)	pubmed:21964608|imex:IM-18122	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5324031|imex:IM-18122-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001269573.1|refseq:NP_001269574.1|ensembl:ENSG00000065675(gene)|ensembl:ENST00000263125(transcript)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001772"(immunological synapse)|go:"GO:0002376"(immune system process)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007411"(axon guidance)|go:"GO:0016235"(aggresome)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0106311"|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000570"(positive regulation of T-helper 2 cell activation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027264|interpro:IPR034668|interpro:IPR035892|mint:Q04759|rcsb pdb:1XJD|rcsb pdb:2ENJ|rcsb pdb:2ENN|rcsb pdb:2ENZ|rcsb pdb:2JED|rcsb pdb:4Q9Z|rcsb pdb:4RA5|rcsb pdb:5F9E|reactome:R-HSA-111465|reactome:R-HSA-114508|reactome:R-HSA-202424|reactome:R-HSA-2514859|reactome:R-HSA-2871837|reactome:R-HSA-373752|reactome:R-HSA-418597|reactome:R-HSA-8936459|reactome:R-HSA-9648002|refseq:NP_001229342.1|refseq:NP_006248.1|refseq:XP_016871899.1|refseq:XP_016871900.1|refseq:NP_001310194.1|refseq:NP_001310195.1|refseq:XP_006717528.1	refseq:NP_001036236.1|refseq:NP_005347.3|ensembl:ENSG00000182866(gene)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|ensembl:ENST00000336890(transcript)|ensembl:ENST00000619559(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001772"(immunological synapse)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|dip:DIP-553N|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051117"(ATPase binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051249"(regulation of lymphocyte activation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903039"(positive regulation of leukocyte cell-cell adhesion)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035749|interpro:IPR035850|interpro:IPR036028|interpro:IPR036860|mint:P06239|rcsb pdb:1BHF|rcsb pdb:1BHH|rcsb pdb:1CWD|rcsb pdb:1CWE|rcsb pdb:1FBZ|rcsb pdb:1H92|rcsb pdb:1IJR|rcsb pdb:1KIK|rcsb pdb:1LCJ|rcsb pdb:1LCK|rcsb pdb:1LKK|rcsb pdb:1LKL|rcsb pdb:1Q68|rcsb pdb:1Q69|rcsb pdb:1QPC|rcsb pdb:1QPD|rcsb pdb:1QPE|rcsb pdb:1QPJ|rcsb pdb:1X27|rcsb pdb:2IIM|rcsb pdb:2OF2|rcsb pdb:2OF4|rcsb pdb:2OFU|rcsb pdb:2OFV|rcsb pdb:2OG8|rcsb pdb:2PL0|rcsb pdb:2ZM1|rcsb pdb:2ZM4|rcsb pdb:2ZYB|rcsb pdb:3AC1|rcsb pdb:3AC2|rcsb pdb:3AC3|rcsb pdb:3AC4|rcsb pdb:3AC5|rcsb pdb:3AC8|rcsb pdb:3ACJ|rcsb pdb:3ACK|rcsb pdb:3AD4|rcsb pdb:3AD5|rcsb pdb:3AD6|rcsb pdb:3B2W|rcsb pdb:3BRH|rcsb pdb:3BYM|rcsb pdb:3BYO|rcsb pdb:3BYS|rcsb pdb:3BYU|rcsb pdb:3KMM|rcsb pdb:3KXZ|rcsb pdb:3LCK|rcsb pdb:3MPM|rcsb pdb:4C3F|rcsb pdb:4D8K|rcsb pdb:5MTM|rcsb pdb:5MTN|rcsb pdb:6H6A|rcsb pdb:6PDJ|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-164944|reactome:R-HSA-167590|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-210990|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-389948|reactome:R-HSA-6811558|reactome:R-HSA-9013407|reactome:R-HSA-9020558|reactome:R-HSA-9670439|reactome:R-HSA-9706374	-	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2012/01/04	2014/10/16	rogid:YzhE3We1rRhZofphmMAeWDDbGaw9606	rogid:AIdRYIcSNXmD2ovQiEn9N4CWr/M9606	intact-crc:55531FF770872632|rigid:52fnqRMjtGXG21Q8t30ejYnNvZo	false	sufficient binding region:282-379|myc tag:n-n	mutation:154-154|mutation decreasing interaction:97-97|mutation disrupting interaction:97-97,154-154	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)