#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35222 uniprotkb:P10275 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126073|imex:IM-17323-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N - - - figure legend:Fig 5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 intact-crc:B3D636A6F1CAA9F8|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P35222 uniprotkb:Q9NSA3 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126073|imex:IM-17323-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 - - - figure legend:Fig 5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 intact-crc:B3D636A6F1CAA9F8|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false glutathione s tranferase tag:?-? 35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P10275 uniprotkb:P35222 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-6126067|imex:IM-17323-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 - - - figure legend:Fig 5B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 intact-crc:8ACD123D45F32415|rigid:e/vNcfV9sFo04itAcgXAeHX2/Aw false 35s radiolabel:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P35222 uniprotkb:Q9NSA3 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126202|imex:IM-17323-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 - - - figure legend:Fig 5C|comment:"Truncated ICAT ( N-terminal region) showed greater GST-beta catenin binding to AR, than full length ICAT."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 intact-crc:C63BA43697327F7B|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false glutathione s tranferase tag:?-? sufficient binding region:1-61 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35222 uniprotkb:P10275 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126202|imex:IM-17323-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N - - - figure legend:Fig 5C|comment:"Truncated ICAT ( N-terminal region) showed greater GST-beta catenin binding to AR, than full length ICAT."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 intact-crc:C63BA43697327F7B|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NSA3 uniprotkb:P10275 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128313|imex:IM-17323-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N - - - figure legend:Fig 5D|comment:Direct binding between ICAT and AR proteins was not detected when beta-catenin was absent.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 intact-crc:2BA403B17A763427|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NSA3 uniprotkb:P35222 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:"MI:0096"(pull down) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6128313|imex:IM-17323-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0684"(ancillary) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 - - - figure legend:Fig 5D|comment:Direct binding between ICAT and AR proteins was not detected when beta-catenin was absent.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/10 2016/03/30 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 intact-crc:2BA403B17A763427|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NSA3 uniprotkb:P10275 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126529|imex:IM-17323-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N - - - figure legend:Fig 5E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 intact-crc:2D55EBD015CC48DA|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NSA3 uniprotkb:P35222 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126529|imex:IM-17323-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 - - - figure legend:Fig 5E|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 intact-crc:2D55EBD015CC48DA|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NSA3 uniprotkb:P10275 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126547|imex:IM-17323-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N - - - figure legend:Fig 6|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 intact-crc:5827262FAAE79888|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NSA3 uniprotkb:P35222 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126547|imex:IM-17323-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 - - - figure legend:Fig 6|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 intact-crc:5827262FAAE79888|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10275 uniprotkb:Q9NSA3 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126556|imex:IM-17323-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 - - - figure legend:Fig 6|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 intact-crc:709BEB7DC5BD63B6|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P10275 uniprotkb:P35222 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 intact:EBI-491549|uniprotkb:Q8NEW9|uniprotkb:Q8NI94|uniprotkb:Q9H391|ensembl:ENSP00000344456|ensembl:ENSP00000379486|ensembl:ENSP00000379488|ensembl:ENSP00000385604|ensembl:ENSP00000387455|ensembl:ENSP00000401599|ensembl:ENSP00000409302|ensembl:ENSP00000412219|ensembl:ENSP00000493533|ensembl:ENSP00000493610|ensembl:ENSP00000494053|ensembl:ENSP00000494411|ensembl:ENSP00000494677|ensembl:ENSP00000494845|ensembl:ENSP00000494914|ensembl:ENSP00000495076|ensembl:ENSP00000495244|ensembl:ENSP00000495360|ensembl:ENSP00000495450|ensembl:ENSP00000495719|ensembl:ENSP00000495992|ensembl:ENSP00000496021|ensembl:ENSP00000496180|ensembl:ENSP00000496385|uniprotkb:A8K1L7|intact:EBI-491563 psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:ctnb1_human(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:OK/SW-cl.35(orf name)|uniprotkb:PRO2286(orf name)|uniprotkb:CTNNB1(gene name)|psi-mi:CTNNB1(display_short)|uniprotkb:CTNNB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126556|imex:IM-17323-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N ensembl:ENSG00000168036(gene)|ensembl:ENST00000349496(transcript)|ensembl:ENST00000396183(transcript)|ensembl:ENST00000396185(transcript)|ensembl:ENST00000405570(transcript)|ensembl:ENST00000431914(transcript)|ensembl:ENST00000441708(transcript)|ensembl:ENST00000450969(transcript)|ensembl:ENST00000642248(transcript)|ensembl:ENST00000642315(transcript)|ensembl:ENST00000642426(transcript)|ensembl:ENST00000642992(transcript)|ensembl:ENST00000643031(transcript)|ensembl:ENST00000643297(transcript)|ensembl:ENST00000643541(transcript)|ensembl:ENST00000643977(transcript)|ensembl:ENST00000643992(transcript)|ensembl:ENST00000644867(transcript)|ensembl:ENST00000645210(transcript)|ensembl:ENST00000645320(transcript)|ensembl:ENST00000645982(transcript)|ensembl:ENST00000433400(transcript)|ensembl:ENST00000646369(transcript)|ensembl:ENST00000647390(transcript)|ensembl:ENST00000646725(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|reactome:R-HSA-351906|reactome:R-HSA-3769402|reactome:R-HSA-3134973|reactome:R-HSA-381771|reactome:R-HSA-4086398|reactome:R-HSA-418990|reactome:R-HSA-4411364|reactome:R-HSA-4641262|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5626467|reactome:R-HSA-8853884|reactome:R-HSA-8876493|reactome:R-HSA-8951430|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048538"(thymus development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030539"(male genitalia development)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035315"(hair cell differentiation)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044336"(canonical Wnt signaling pathway involved in negative regulation of apoptotic process)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0060066"(oviduct development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060440"(trachea formation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0005916"(fascia adherens)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:P35222|rcsb pdb:1G3J|rcsb pdb:1JDH|rcsb pdb:1JPW|rcsb pdb:1LUJ|rcsb pdb:1P22|rcsb pdb:1QZ7|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:2G57|rcsb pdb:2GL7|rcsb pdb:2Z6H|rcsb pdb:3DIW|rcsb pdb:3FQN|rcsb pdb:3FQR|rcsb pdb:3SL9|rcsb pdb:3SLA|rcsb pdb:3TX7|rcsb pdb:4DJS|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O9B|rcsb pdb:6O9C|rcsb pdb:6WLX|rcsb pdb:6WNX|rcsb pdb:7AFW|go:"GO:0072053"(renal inner medulla development)|rcsb pdb:7AR4|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-201722|go:"GO:0000791"(euchromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001708"(cell fate specification)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001840"(neural plate development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|dip:DIP-122N|refseq:NP_001091679.1|refseq:NP_001091680.1|refseq:NP_001895.1|refseq:XP_005264943.1|refseq:XP_016861227.1 - - - figure legend:Fig 6|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 rogid:WLs7+T0WG4DiBStdS5+lR7i83dk9606 intact-crc:709BEB7DC5BD63B6|rigid:FbP01NaNiqXSruIQivGLsQaUbxs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) ensembl:ENSG00000142515 uniprotkb:P10275 intact:EBI-1776214 intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6 psi-mi:klk3_human_gene(display_short)|psi-mi:ENSG00000142515(display_long) psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126569|imex:IM-17323-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0250"(gene) psi-mi:"MI:0326"(protein) - ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N - - - figure legend:Fig 6E|agonist:DHT|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2016/03/30 - rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606 intact-crc:316B86E2D8263035 false binding-associated region:?-?|binding-associated region:?-?|binding-associated region:?-? - - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr) uniprotkb:Q9NSA3 ensembl:ENSG00000142515 intact:EBI-747082|ensembl:ENSP00000366466|ensembl:ENSP00000366468|ensembl:ENSP00000366474|ensembl:ENSP00000383696|uniprotkb:Q5T4V2 intact:EBI-1776214 psi-mi:cnbp1_human(display_long)|uniprotkb:Inhibitor of beta-catenin and Tcf-4(gene name synonym)|uniprotkb:CTNNBIP1(gene name)|psi-mi:CTNNBIP1(display_short)|uniprotkb:ICAT(gene name synonym) psi-mi:klk3_human_gene(display_short)|psi-mi:ENSG00000142515(display_long) psi-mi:"MI:0402"(chromatin immunoprecipitation assay) Zhuo et al. (2011) pubmed:21885566|imex:IM-17323 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-6126580|imex:IM-17323-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0250"(gene) refseq:NP_001012329.1|refseq:NP_064633.1|ensembl:ENSG00000178585(gene)|ensembl:ENST00000377256(transcript)|ensembl:ENST00000377258(transcript)|ensembl:ENST00000377263(transcript)|ensembl:ENST00000400904(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0002528"(regulation of vascular permeability involved in acute inflammatory response)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0060633"(negative regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|interpro:IPR009428(Beta-catenin-interacting ICAT)|interpro:IPR036911|interpro:IPR042999|rcsb pdb:1LUJ|rcsb pdb:1M1E|rcsb pdb:1T08|reactome:R-HSA-3769402|refseq:XP_016857342.1|refseq:XP_016857343.1|refseq:XP_016857344.1 - - - - figure legend:Fig 6E|agonist:DHT|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-lapc4)|taxid:9606(Homo sapiens LAPC4 cells derived from a human prostate cancer xenograft) - 2012/05/10 2014/10/16 rogid:+u/qGVFIboIBdcxthYr2OA1US3w9606 - intact-crc:1C454D54DF7AE0E7 false - binding-associated region:?-?|binding-associated region:?-?|binding-associated region:?-? - - psi-mi:"MI:0088"(primer specific pcr) psi-mi:"MI:0088"(primer specific pcr)