#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8C669	uniprotkb:P15307	intact:EBI-5323754|uniprotkb:Q91YL9|uniprotkb:Q9CV22|uniprotkb:Q9ERJ8|ensembl:ENSMUSP00000090979|ensembl:ENSMUSP00000099018	intact:EBI-5323778	psi-mi:peli1_mouse(display_long)|uniprotkb:Peli1(gene name)|psi-mi:Peli1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 1(gene name synonym)	psi-mi:rel_mouse(display_long)|uniprotkb:Rel(gene name)|psi-mi:Rel(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chang et al. (2011)	pubmed:21874024|imex:IM-16645	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5323776|imex:IM-16645-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075813.2|dip:DIP-48336N|ensembl:ENSMUSG00000020134(gene)|ensembl:ENSMUST00000093290(transcript)|ensembl:ENSMUST00000101477(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043331"(response to dsRNA)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR006800(Pellino)|reactome:R-MMU-5675482|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-975144	dip:DIP-59241N|reactome:R-MMU-1169091|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030505|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|interpro:IPR042845	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7B|agonist:CD3 and CD28 Ab cross-linking|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-t-cell)|taxid:10090(Mouse T cell)	-	2012/01/04	2014/10/16	rogid:6QNHjh1DlQRB0iojsb+3fQj8AJI10090	rogid:nBmYOU9oy70IMqXtGgSd4rTB5Vk10090	intact-crc:5E3751F22742ECFA|rigid:MT+NVWLORhapRJyez70809aSuOA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15307	uniprotkb:Q96FA3	intact:EBI-5323778	intact:EBI-448369|uniprotkb:Q96SM0|uniprotkb:Q9GZY5|uniprotkb:Q9HCX0|ensembl:ENSP00000351789	psi-mi:rel_mouse(display_long)|uniprotkb:Rel(gene name)|psi-mi:Rel(display_short)	psi-mi:peli1_human(display_long)|uniprotkb:Pellino-related intracellular-signaling molecule(gene name synonym)|uniprotkb:PELI1(gene name)|psi-mi:PELI1(display_short)|uniprotkb:PRISM(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chang et al. (2011)	pubmed:21874024|imex:IM-16645	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-5323805|imex:IM-16645-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-59241N|reactome:R-MMU-1169091|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030505|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|interpro:IPR042845	refseq:NP_065702.2|refseq:XP_011531296.1|refseq:XP_016860009.1|dip:DIP-32488N|ensembl:ENSG00000197329(gene)|ensembl:ENST00000358912(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043331"(response to dsRNA)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q96FA3|reactome:R-HSA-5675482|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7C, 7D, 7E, S11|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/01/04	2014/10/16	rogid:nBmYOU9oy70IMqXtGgSd4rTB5Vk10090	rogid:GbzrXWXiw4Kv/zN4kEscEKPkEXQ9606	intact-crc:8C4512DC8E6A4683|rigid:jGOUU3dwJ/qEfNmRqiVoyKLp234	false	-	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)