#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3UQN2	uniprotkb:Q3UQN2	intact:EBI-6094986|uniprotkb:Q3UJ91|uniprotkb:Q7TMS9|uniprotkb:Q8C0I2|ensembl:ENSMUSP00000042959	intact:EBI-6094986|uniprotkb:Q3UJ91|uniprotkb:Q7TMS9|uniprotkb:Q8C0I2|ensembl:ENSMUSP00000042959	psi-mi:fcho2_mouse(display_long)|uniprotkb:Fcho2(gene name)|psi-mi:Fcho2(display_short)	psi-mi:fcho2_mouse(display_long)|uniprotkb:Fcho2(gene name)|psi-mi:Fcho2(display_short)	psi-mi:"MI:0091"(chromatography technology)	Uezu et al. (2011)	pubmed:21762413	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6095001	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0503"(self)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766179.2|dip:DIP-29489N|ensembl:ENSMUSG00000041685(gene)|ensembl:ENSMUST00000040340(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|mint:Q3UQN2|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_766179.2|dip:DIP-29489N|ensembl:ENSMUSG00000041685(gene)|ensembl:ENSMUST00000040340(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|mint:Q3UQN2|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:fig 3|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/11	2014/10/16	rogid:0+FhOCmcIH+a08hD9KmSTtW5XDw10090	rogid:0+FhOCmcIH+a08hD9KmSTtW5XDw10090	intact-crc:0E0CF2EE6BC40663|rigid:jDaQFnnzRl/rNGKvLwDqRHOBaOo	false	-	-	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3UQN2	uniprotkb:A7BFV9	intact:EBI-6094986|uniprotkb:Q3UJ91|uniprotkb:Q7TMS9|uniprotkb:Q8C0I2|ensembl:ENSMUSP00000042959	intact:EBI-6095043	psi-mi:fcho2_mouse(display_long)|uniprotkb:Fcho2(gene name)|psi-mi:Fcho2(display_short)	psi-mi:a7bfv9_rat(display_long)	psi-mi:"MI:0096"(pull down)	Uezu et al. (2011)	pubmed:21762413	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6095057	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766179.2|dip:DIP-29489N|ensembl:ENSMUSG00000041685(gene)|ensembl:ENSMUST00000040340(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|mint:Q3UQN2|reactome:R-MMU-8856825|reactome:R-MMU-8856828	mint:A7BFV9|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR003903(Ubiquitin interacting motif)|go:"GO:0005509"(calcium ion binding)	-	-	-	figure legend:fig 5A|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/11	2014/10/16	rogid:0+FhOCmcIH+a08hD9KmSTtW5XDw10090	rogid:R3E+FrsPBjI+M4QkNZ8lboaInKw10116	intact-crc:22A772DF46AD8892|rigid:UFngWef5HpdDTmOfZ4qt0djVWRQ	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P42566	uniprotkb:Q0JRZ9	intact:EBI-396684|uniprotkb:B2R8J7|uniprotkb:Q5SRH4|uniprotkb:D3DPJ2|intact:EBI-28966731|ensembl:ENSP00000360798	intact:EBI-2609756|uniprotkb:Q0JTJ3|uniprotkb:B2RNQ9|uniprotkb:A8K6W7|uniprotkb:Q96CF5|ensembl:ENSP00000393776|uniprotkb:B4DHK0|uniprotkb:E9PG79	psi-mi:eps15_human(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:fcho2_human(display_long)|uniprotkb:FCHO2(gene name)|psi-mi:FCHO2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Uezu et al. (2011)	pubmed:21762413	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6095096	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153441.1|refseq:NP_001972.1|ensembl:ENSP00000360798|ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P42566|rcsb pdb:1C07|rcsb pdb:1EH2|rcsb pdb:1F8H|rcsb pdb:1FF1|rcsb pdb:2IV9|rcsb pdb:2JXC|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4S0G|rcsb pdb:5AWT|rcsb pdb:5AWU|rcsb pdb:5JP2|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|dip:DIP-33064N	refseq:NP_001139504.1|refseq:NP_620137.2|ensembl:ENST00000430046(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|rcsb pdb:2V0O|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000157107(gene)|dip:DIP-29488N	-	-	-	figure legend:fig 5B|curation depth:mimix curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/04/11	2014/10/16	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	rogid:JYPt0L04ZvoacrpUFy49uFWxD489606	intact-crc:D662E974951AD192|rigid:wRxZD/V/rBd2Lf0YmGFL20lBD+Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q0JRZ9	uniprotkb:O95782	intact:EBI-2609756|uniprotkb:Q0JTJ3|uniprotkb:B2RNQ9|uniprotkb:A8K6W7|uniprotkb:Q96CF5|ensembl:ENSP00000393776|uniprotkb:B4DHK0|uniprotkb:E9PG79	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	psi-mi:fcho2_human(display_long)|uniprotkb:FCHO2(gene name)|psi-mi:FCHO2(display_short)	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Uezu et al. (2011)	pubmed:21762413	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6095073	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139504.1|refseq:NP_620137.2|ensembl:ENST00000430046(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|rcsb pdb:2V0O|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000157107(gene)|dip:DIP-29488N	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	-	-	-	figure legend:fig 5B|curation depth:mimix curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/04/11	2014/10/16	rogid:JYPt0L04ZvoacrpUFy49uFWxD489606	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	intact-crc:28AC8C8A002491CA|rigid:QLFogY9gd6iswD3aTiSN0MjfLQk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42566	uniprotkb:Q0JRZ9	intact:EBI-396684|uniprotkb:B2R8J7|uniprotkb:Q5SRH4|uniprotkb:D3DPJ2|intact:EBI-28966731|ensembl:ENSP00000360798	intact:EBI-2609756|uniprotkb:Q0JTJ3|uniprotkb:B2RNQ9|uniprotkb:A8K6W7|uniprotkb:Q96CF5|ensembl:ENSP00000393776|uniprotkb:B4DHK0|uniprotkb:E9PG79	psi-mi:eps15_human(display_long)|uniprotkb:EPS15(gene name)|psi-mi:EPS15(display_short)|uniprotkb:AF1P(gene name synonym)|uniprotkb:Protein AF-1p(gene name synonym)	psi-mi:fcho2_human(display_long)|uniprotkb:FCHO2(gene name)|psi-mi:FCHO2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Uezu et al. (2011)	pubmed:21762413	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6095069	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153441.1|refseq:NP_001972.1|ensembl:ENSP00000360798|ensembl:ENSG00000085832(gene)|ensembl:ENST00000371733(transcript)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P42566|rcsb pdb:1C07|rcsb pdb:1EH2|rcsb pdb:1F8H|rcsb pdb:1FF1|rcsb pdb:2IV9|rcsb pdb:2JXC|rcsb pdb:4RH5|rcsb pdb:4RH9|rcsb pdb:4RHG|rcsb pdb:4S0G|rcsb pdb:5AWT|rcsb pdb:5AWU|rcsb pdb:5JP2|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|dip:DIP-33064N	refseq:NP_001139504.1|refseq:NP_620137.2|ensembl:ENST00000430046(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|rcsb pdb:2V0O|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000157107(gene)|dip:DIP-29488N	-	-	-	figure legend:fig 7A|curation depth:mimix curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/04/11	2014/10/16	rogid:8wPyg852YodFBHvQ0Rocp8DQvxs9606	rogid:JYPt0L04ZvoacrpUFy49uFWxD489606	intact-crc:6689608657AE4309|rigid:wRxZD/V/rBd2Lf0YmGFL20lBD+Q	false	-	-	-	-	psi-mi:"MI:0709"(polyclonal antibody immunostaining)	psi-mi:"MI:0709"(polyclonal antibody immunostaining)
uniprotkb:O95782	uniprotkb:Q0JRZ9	intact:EBI-353552|uniprotkb:Q96CI7|uniprotkb:Q96PP6|uniprotkb:Q96PP7|uniprotkb:Q9H070|intact:EBI-28973302|ensembl:ENSP00000351926	intact:EBI-2609756|uniprotkb:Q0JTJ3|uniprotkb:B2RNQ9|uniprotkb:A8K6W7|uniprotkb:Q96CF5|ensembl:ENSP00000393776|uniprotkb:B4DHK0|uniprotkb:E9PG79	psi-mi:ap2a1_human(display_long)|uniprotkb:AP2A1(gene name)|psi-mi:AP2A1(display_short)|uniprotkb:ADTAA(gene name synonym)|uniprotkb:CLAPA1(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit alpha-1(gene name synonym)|uniprotkb:Alpha1-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit(gene name synonym)|uniprotkb:Alpha-adaptin A(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 alpha-A large chain(gene name synonym)|uniprotkb:100 kDa coated vesicle protein A(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit alpha-1(gene name synonym)	psi-mi:fcho2_human(display_long)|uniprotkb:FCHO2(gene name)|psi-mi:FCHO2(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Uezu et al. (2011)	pubmed:21762413	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6095092	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055018.2|refseq:NP_570603.2|ensembl:ENST00000354293|ensembl:ENSP00000346246|ensembl:ENSP00000351926|ensembl:ENSG00000196961(gene)|ensembl:ENST00000359032(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0140312"(cargo adaptor activity)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR003164(Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017104(Adaptor protein complex AP-2, alpha subunit)|mint:O95782|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|dip:DIP-33164N	refseq:NP_001139504.1|refseq:NP_620137.2|ensembl:ENST00000430046(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0010324"(membrane invagination)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098835"(presynaptic endocytic zone membrane)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR018808|interpro:IPR027267|interpro:IPR028565|interpro:IPR030122|interpro:IPR031160|rcsb pdb:2V0O|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000157107(gene)|dip:DIP-29488N	-	-	-	figure legend:fig 7A|curation depth:mimix curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/04/11	2014/10/16	rogid:egkaIAhvIi1FqNr+8KEFeJaYZcc9606	rogid:JYPt0L04ZvoacrpUFy49uFWxD489606	intact-crc:8F17FEEF391BF5E7|rigid:QLFogY9gd6iswD3aTiSN0MjfLQk	false	-	-	-	-	psi-mi:"MI:0709"(polyclonal antibody immunostaining)	psi-mi:"MI:0709"(polyclonal antibody immunostaining)