#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13370	uniprotkb:O95398	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172854	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	-	-	-	figure legend:1A|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:77C95C01E45BC4D8|rigid:2wdusEncYDd7t364gWbuQxgPaqA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5UE93	uniprotkb:Q13370	intact:EBI-6172907|intact:EBI-28983057|ensembl:ENSP00000480157|uniprotkb:Q658R3	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	psi-mi:pi3r6_human(display_long)|uniprotkb:PIK3R6(gene name)|psi-mi:PIK3R6(display_short)|uniprotkb:C17orf38(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000276231(gene)|ensembl:ENST00000619866(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-HSA-114604|reactome:R-HSA-1660499|reactome:R-HSA-392451|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSP00000480157|refseq:NP_001010855.1|refseq:XP_016879718.1	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	-	-	-	figure legend:2A|agonist:"PIK3CG (AC P48736)"|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2012/07/05	2014/10/16	rogid:K7+vRy32t+avHsaeYl25L6Qq1HM9606	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	intact-crc:C94BF10FDF1ED42D|rigid:0lmg3BH7sjS0zixgoenNZ1X2+YU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95398	uniprotkb:Q13370	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172902	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	-	-	-	figure legend:1B|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	intact-crc:0194E62C84BEAF9E|rigid:2wdusEncYDd7t364gWbuQxgPaqA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5UE93	uniprotkb:O95398	intact:EBI-6172907|intact:EBI-28983057|ensembl:ENSP00000480157|uniprotkb:Q658R3	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:pi3r6_human(display_long)|uniprotkb:PIK3R6(gene name)|psi-mi:PIK3R6(display_short)|uniprotkb:C17orf38(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172927	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000276231(gene)|ensembl:ENST00000619866(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-HSA-114604|reactome:R-HSA-1660499|reactome:R-HSA-392451|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSP00000480157|refseq:NP_001010855.1|refseq:XP_016879718.1	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	-	-	-	figure legend:2B|agonist:"PDE3B  (AC Q13370)"|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:K7+vRy32t+avHsaeYl25L6Qq1HM9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:7809DFCA6C0737D6|rigid:Rit65V9S+CFzE7FZbuLhwXwzn+g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13370	uniprotkb:O95398	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	-	-	-	figure legend:S2|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:0F73712D5E863BDD|rigid:2wdusEncYDd7t364gWbuQxgPaqA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13370	uniprotkb:O95398	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172987	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	-	-	-	figure legend:3A|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:ED3185BCE8E5680E|rigid:2wdusEncYDd7t364gWbuQxgPaqA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O95398	uniprotkb:Q13370	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172991	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	-	-	-	figure legend:3B|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	intact-crc:8FDD8D4646164CA9|rigid:2wdusEncYDd7t364gWbuQxgPaqA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13370	uniprotkb:Q5UE93	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172907|intact:EBI-28983057|ensembl:ENSP00000480157|uniprotkb:Q658R3	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:pi3r6_human(display_long)|uniprotkb:PIK3R6(gene name)|psi-mi:PIK3R6(display_short)|uniprotkb:C17orf38(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6172995	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000276231(gene)|ensembl:ENST00000619866(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-HSA-114604|reactome:R-HSA-1660499|reactome:R-HSA-392451|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSP00000480157|refseq:NP_001010855.1|refseq:XP_016879718.1	-	-	-	figure legend:3B|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:K7+vRy32t+avHsaeYl25L6Qq1HM9606	intact-crc:E34E055C009C7A82|rigid:0lmg3BH7sjS0zixgoenNZ1X2+YU	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13370	uniprotkb:Q5UE93	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172907|intact:EBI-28983057|ensembl:ENSP00000480157|uniprotkb:Q658R3	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:pi3r6_human(display_long)|uniprotkb:PIK3R6(gene name)|psi-mi:PIK3R6(display_short)|uniprotkb:C17orf38(gene name synonym)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173022	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000276231(gene)|ensembl:ENST00000619866(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-HSA-114604|reactome:R-HSA-1660499|reactome:R-HSA-392451|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|ensembl:ENSP00000480157|refseq:NP_001010855.1|refseq:XP_016879718.1	-	-	-	figure legend:4B|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:K7+vRy32t+avHsaeYl25L6Qq1HM9606	intact-crc:2237B8F21F06BD71|rigid:bAxW9W9TICsbZJwiweD8m7rCBeA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13370	uniprotkb:P48736	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173022	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	-	-	-	figure legend:4B|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	intact-crc:2237B8F21F06BD71|rigid:bAxW9W9TICsbZJwiweD8m7rCBeA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13370	uniprotkb:O95398	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173022	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	-	-	-	figure legend:4B|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:2237B8F21F06BD71|rigid:bAxW9W9TICsbZJwiweD8m7rCBeA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13370	uniprotkb:O95398	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173092	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	-	-	-	figure legend:6A|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	intact-crc:EE211D46774CC655|rigid:65+CTG/GEajjnMaJr5J9inImSz0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13370	uniprotkb:P48736	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173092	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	-	-	-	figure legend:6A|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	intact-crc:EE211D46774CC655|rigid:65+CTG/GEajjnMaJr5J9inImSz0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48736	uniprotkb:Q13370	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173099	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	-	-	-	figure legend:4D|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	intact-crc:5AFCE8FB61058DE6|rigid:n+tvTodaMk2chICAH3tJu529hNs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95398	uniprotkb:Q13370	intact:EBI-6172806|ensembl:ENSP00000373864|ensembl:ENSP00000395708|uniprotkb:O95634|uniprotkb:Q8WVN0|uniprotkb:A8K2G5|uniprotkb:E7EQC8	intact:EBI-6172856|intact:EBI-28976636|ensembl:ENSP00000282096|uniprotkb:O00639|uniprotkb:Q14408|uniprotkb:Q6SEI4|uniprotkb:B7ZM37	psi-mi:rpgf3_human(display_long)|uniprotkb:RAPGEF3(gene name)|psi-mi:RAPGEF3(display_short)|uniprotkb:CGEF1(gene name synonym)|uniprotkb:EPAC(gene name synonym)|uniprotkb:EPAC1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:Rap1 guanine-nucleotide-exchange factor directly activated by cAMP(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:pde3b_human(display_long)|uniprotkb:PDE3B(gene name)|psi-mi:PDE3B(display_short)|uniprotkb:CGIPDE1(gene name synonym)|uniprotkb:Cyclic GMP-inhibited phosphodiesterase B(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Wilson et al. (2011)	pubmed:21393242	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6173111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000079337(gene)|ensembl:ENST00000389212(transcript)|ensembl:ENST00000449771(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0007165"(signal transduction)|go:"GO:0012505"(endomembrane system)|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|mint:O95398|rcsb pdb:6H7E|reactome:R-HSA-354192|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|go:"GO:0016020"(membrane)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030552"(cAMP binding)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|refseq:NP_001092002.1|refseq:NP_006096.2	ensembl:ENSG00000152270(gene)|ensembl:ENST00000282096(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0004119"(cGMP-inhibited cyclic-nucleotide phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0050995"(negative regulation of lipid catabolic process)|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023174|interpro:IPR036971|rcsb pdb:1SO2|rcsb pdb:1SOJ|reactome:R-HSA-165160|reactome:R-HSA-418555|ensembl:ENSP00000282096|ensembl:ENST00000455098|ensembl:ENSP00000388644|refseq:NP_000913.2	-	-	-	figure legend:7B|curation depth:mimix curation	taxid:9606(human-haec)|taxid:9606(Homo sapiens arterial endothelial cells)	-	2012/07/05	2014/10/16	rogid:JTvCAJZQHQvt9s2Z2GDOszHq0pk9606	rogid:gJwPGP14V+pxXalmCSCzhtYHnTk9606	intact-crc:28827997AF49CDA9|rigid:2wdusEncYDd7t364gWbuQxgPaqA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)