#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07228	uniprotkb:P12003	intact:EBI-5606437	intact:EBI-1039563|uniprotkb:Q91024|ensembl:ENSGALP00000008131	psi-mi:itb1_chick(display_long)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:CSAT antigen(gene name synonym)|uniprotkb:JG22 antigen(gene name synonym)|uniprotkb:RGD-receptor(gene name synonym)	psi-mi:vinc_chick(display_long)|uniprotkb:VCL(gene name)|psi-mi:VCL(display_short)|uniprotkb:VINC1(gene name synonym)|uniprotkb:Metavinculin(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5847248|imex:IM-17257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR040622|interpro:IPR032695|interpro:IPR036349|interpro:IPR036465|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR033760|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:1990782"(protein tyrosine kinase binding)	refseq:XP_015143689.1|refseq:NP_990772.1|ensembl:ENSGALG00000005079(gene)|ensembl:ENSGALT00000008145(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0005927"(muscle tendon junction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043034"(costamere)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048675"(axon extension)|go:"GO:0051015"(actin filament binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|rcsb pdb:1QKR|rcsb pdb:1ST6|rcsb pdb:1T01|rcsb pdb:1U6H|rcsb pdb:1XWJ|rcsb pdb:1ZVZ|rcsb pdb:1ZW2|rcsb pdb:1ZW3|rcsb pdb:2GDC|rcsb pdb:3JBI|rcsb pdb:3ZDL|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:6FQ4|rcsb pdb:6NR7|reactome:R-GGA-114608|reactome:R-GGA-445355|reactome:R-GGA-5674135|reactome:R-GGA-6798695|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098723"(skeletal muscle myofibril)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:P12003|dip:DIP-35191N	-	-	-	figure legend:Fig 2.|isoform-comment:The chick alpha-actinin has multiple isoforms. The protein included in this entry is alpha-actinin 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/14	2014/10/16	rogid:Bl4Bm5Na2K6vmRO4hzIPLL0c+do9031	rogid:94z6CivjYryFIKVVE4dRTbssflA9031	intact-crc:CFBF061F62E88438|rigid:d3JrfGh+TH3zpCCS28MsSxPWG+I	false	sufficient binding region:757-803	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07228	uniprotkb:P05094	intact:EBI-5606437	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	psi-mi:itb1_chick(display_long)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:CSAT antigen(gene name synonym)|uniprotkb:JG22 antigen(gene name synonym)|uniprotkb:RGD-receptor(gene name synonym)	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5847248|imex:IM-17257-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR040622|interpro:IPR032695|interpro:IPR036349|interpro:IPR036465|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR033760|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:1990782"(protein tyrosine kinase binding)	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	-	-	-	figure legend:Fig 2.|isoform-comment:The chick alpha-actinin has multiple isoforms. The protein included in this entry is alpha-actinin 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/14	2014/10/16	rogid:Bl4Bm5Na2K6vmRO4hzIPLL0c+do9031	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	intact-crc:CFBF061F62E88438|rigid:d3JrfGh+TH3zpCCS28MsSxPWG+I	false	sufficient binding region:757-803	35s radiolabel:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05094	uniprotkb:P07228	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	intact:EBI-5606437	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:itb1_chick(display_long)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:CSAT antigen(gene name synonym)|uniprotkb:JG22 antigen(gene name synonym)|uniprotkb:RGD-receptor(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5847700|imex:IM-17257-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	interpro:IPR040622|interpro:IPR032695|interpro:IPR036349|interpro:IPR036465|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR033760|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:1990782"(protein tyrosine kinase binding)	-	-	-	figure legend:Fig 3B, 4, 5, 6B.|isoform-comment:The chick alpha-actinin has multiple isoforms. The protein included in this entry is alpha-actinin 1.|comment:"Binding of 125I-alpha-actinin to integrin beta-1 peptide was inhibited by the addition of increasing concentrations of unlabeled alpha-actinin, free integrin beta-1 peptide and tropomyosin (Fig 4). Binding of 125I-alpha-actinin was inhibited in the presence of higher concentrations of F-actin (Fig 5). eta-1 peptide and tropomyosin (Fig 4). Binding of 125I-alpha-actinin was inhibited in the presence of rod-like fragment of alpha-actinin (Fig 6B)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.6x10^-6	2012/03/14	2014/10/16	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	rogid:Bl4Bm5Na2K6vmRO4hzIPLL0c+do9031	intact-crc:B249911FCCCDBE08|rigid:qrMVwd8HkS0pdduRYfPSJcpP1Rk	false	125i radiolabel:?-?	sufficient binding region:757-803	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P07228	uniprotkb:P05094	intact:EBI-5606437	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	psi-mi:itb1_chick(display_long)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:CSAT antigen(gene name synonym)|uniprotkb:JG22 antigen(gene name synonym)|uniprotkb:RGD-receptor(gene name synonym)	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5848081|imex:IM-17257-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR040622|interpro:IPR032695|interpro:IPR036349|interpro:IPR036465|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR033760|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:1990782"(protein tyrosine kinase binding)	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	-	-	-	figure legend:Fig 7B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.5x10^-6(molar)	2012/03/14	2014/10/16	rogid:Bl4Bm5Na2K6vmRO4hzIPLL0c+do9031	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	intact-crc:1334E33C06B31989|rigid:qrMVwd8HkS0pdduRYfPSJcpP1Rk	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P05094	uniprotkb:P05106	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5848124|imex:IM-17257-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:Fig 7C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.1x10^-6	2012/03/14	2014/10/16	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	intact-crc:10FCEA2677B9D03E|rigid:OvVuejqW4egmBd0XO0COWjwzw+U	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P05106	uniprotkb:P05094	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5852845|imex:IM-17257-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	-	-	-	figure legend:Fig 8.|isoform-comment:The chick alpha-actinin has multiple isoforms. The protein included in this entry is alpha-actinin 1.|comment:The binding of 125I-alpha-actinin to liposome-enclosed GP IIa/IIIb was inhibited in the presence of increasing concentrations of unlabeled alpha-actinin and free integrin-beta peptides.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/03/14	2014/10/16	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	intact-crc:E38F43FFCE4F82E3|rigid:OvVuejqW4egmBd0XO0COWjwzw+U	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P05094	uniprotkb:P07228	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	intact:EBI-5606437	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:itb1_chick(display_long)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:CSAT antigen(gene name synonym)|uniprotkb:JG22 antigen(gene name synonym)|uniprotkb:RGD-receptor(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Otey et al. (1990)	pubmed:2116421|imex:IM-17257	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-5863685|imex:IM-17257-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	interpro:IPR040622|interpro:IPR032695|interpro:IPR036349|interpro:IPR036465|interpro:IPR013111(EGF, extracellular)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR033760|go:"GO:0001968"(fibronectin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:1990782"(protein tyrosine kinase binding)	-	-	-	figure legend:Fig 9.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	-	2012/03/14	2014/10/16	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	rogid:Bl4Bm5Na2K6vmRO4hzIPLL0c+do9031	intact-crc:A90CC8C6C1908FD0|rigid:qrMVwd8HkS0pdduRYfPSJcpP1Rk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)