#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97767	uniprotkb:Q62232	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-1368736|uniprotkb:P70179|ensembl:ENSMUSP00000024947|ensembl:ENSMUSP00000125871	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:six2_mouse(display_long)|uniprotkb:Six2(gene name)|psi-mi:Six2(display_short)|uniprotkb:Sine oculis homeobox homolog 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6140919|imex:IM-17347-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_035510.1|interpro:IPR031701|interpro:IPR017970|ensembl:ENSMUSG00000024134(gene)|ensembl:ENSMUST00000024947(transcript)|ensembl:ENSMUST00000163568(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001656"(metanephros development)|go:"GO:0001822"(kidney development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0016477"(cell migration)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032330"(regulation of chondrocyte differentiation)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0072006"(nephron development)|go:"GO:0072028"(nephron morphogenesis)|go:"GO:0072038"(mesenchymal stem cell maintenance involved in nephron morphogenesis)|go:"GO:0072137"(condensed mesenchymal cell proliferation)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0090189"(regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0097168"(mesenchymal stem cell proliferation)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:+VNU0yexe/7PF/VqC2PNcmxgnvA10090	intact-crc:F98B68E3C9DEA414|rigid:6uTakzcmlb1MMRH4NxPU6dqT4vc	false	sufficient binding region:291-591(IPR006545)	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97767	uniprotkb:Q91WA6	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6140925|imex:IM-17347-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:EF5186AC377A480F|rigid:vAcL6/viW9QwXZUJcOK+52QrqKY	false	sufficient binding region:291-591	sufficient binding region:1-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97767	uniprotkb:Q9WUB0	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-6141072|uniprotkb:A2ANR4|uniprotkb:Q3TM86|uniprotkb:Q8C2I0|ensembl:ENSMUSP00000028964|ensembl:ENSMUSP00000105473	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:hoil1_mouse(display_long)|uniprotkb:Rbck1(gene name)|psi-mi:Rbck1(display_short)|uniprotkb:Rbck(gene name synonym)|uniprotkb:Ubce7ip3(gene name synonym)|uniprotkb:Uip28(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1 homolog(gene name synonym)|uniprotkb:UbcM4-interacting protein 28(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6141105|imex:IM-17347-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_001077390.1|refseq:NP_062679.2|dip:DIP-59198N|ensembl:ENSMUSG00000027466(gene)|ensembl:ENSMUST00000028964(transcript)|ensembl:ENSMUST00000109847(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-983168	-	-	-	figure legend:Fig. 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:BrdBce5XWr8fSk3w0rPsymbLpC410090	intact-crc:2CBDE4E285CE1CDC|rigid:0MiicmfjfT+KmPhGPdO5hSJz/vs	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08575	uniprotkb:Q9WUB0	intact:EBI-986503|uniprotkb:P97925|ensembl:ENSMUSP00000066244|ensembl:ENSMUSP00000085455|uniprotkb:A2A5S4	intact:EBI-6141072|uniprotkb:A2ANR4|uniprotkb:Q3TM86|uniprotkb:Q8C2I0|ensembl:ENSMUSP00000028964|ensembl:ENSMUSP00000105473	psi-mi:eya2_mouse(display_long)|uniprotkb:Eya2(gene name)|psi-mi:Eya2(display_short)|uniprotkb:Eab1(gene name synonym)	psi-mi:hoil1_mouse(display_long)|uniprotkb:Rbck1(gene name)|psi-mi:Rbck1(display_short)|uniprotkb:Rbck(gene name synonym)|uniprotkb:Ubce7ip3(gene name synonym)|uniprotkb:Uip28(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1 homolog(gene name synonym)|uniprotkb:UbcM4-interacting protein 28(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6172326|imex:IM-17347-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017897(gene)|ensembl:ENSMUST00000063433(transcript)|ensembl:ENSMUST00000088132(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0048856"(anatomical structure development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028473|interpro:IPR036412|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|refseq:NP_034295.1|refseq:NP_001258891.1|refseq:NP_001258892.1	refseq:NP_001077390.1|refseq:NP_062679.2|dip:DIP-59198N|ensembl:ENSMUSG00000027466(gene)|ensembl:ENSMUST00000028964(transcript)|ensembl:ENSMUST00000109847(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-983168	-	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/01	2014/10/16	rogid:pYM3Q0D4uhVNjMKJCatXk+1c92A10090	rogid:BrdBce5XWr8fSk3w0rPsymbLpC410090	intact-crc:A3960A23C925E147|rigid:0KTUYOmA6VvIved34T2Q29eaMe8	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97767	uniprotkb:Q91WA6	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0096"(pull down)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6140949|imex:IM-17347-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:4C179270FD171B88|rigid:vAcL6/viW9QwXZUJcOK+52QrqKY	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O08575	uniprotkb:Q91WA6	intact:EBI-986503|uniprotkb:P97925|ensembl:ENSMUSP00000066244|ensembl:ENSMUSP00000085455|uniprotkb:A2A5S4	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:eya2_mouse(display_long)|uniprotkb:Eya2(gene name)|psi-mi:Eya2(display_short)|uniprotkb:Eab1(gene name synonym)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0096"(pull down)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6171646|imex:IM-17347-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017897(gene)|ensembl:ENSMUST00000063433(transcript)|ensembl:ENSMUST00000088132(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0048856"(anatomical structure development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028473|interpro:IPR036412|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|refseq:NP_034295.1|refseq:NP_001258891.1|refseq:NP_001258892.1	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/01	2014/10/16	rogid:pYM3Q0D4uhVNjMKJCatXk+1c92A10090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:9AC2C924974D0E62|rigid:iUKn5wH9cC0iGsjorcCQ7Dc/kNQ	false	ha tag:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97767	uniprotkb:Q91WA6	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6140980|imex:IM-17347-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:3E1109144C10012A|rigid:vAcL6/viW9QwXZUJcOK+52QrqKY	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97767	uniprotkb:Q9WUB0	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-6141072|uniprotkb:A2ANR4|uniprotkb:Q3TM86|uniprotkb:Q8C2I0|ensembl:ENSMUSP00000028964|ensembl:ENSMUSP00000105473	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:hoil1_mouse(display_long)|uniprotkb:Rbck1(gene name)|psi-mi:Rbck1(display_short)|uniprotkb:Rbck(gene name synonym)|uniprotkb:Ubce7ip3(gene name synonym)|uniprotkb:Uip28(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1 homolog(gene name synonym)|uniprotkb:UbcM4-interacting protein 28(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6172261|imex:IM-17347-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_001077390.1|refseq:NP_062679.2|dip:DIP-59198N|ensembl:ENSMUSG00000027466(gene)|ensembl:ENSMUST00000028964(transcript)|ensembl:ENSMUST00000109847(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-983168	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:BrdBce5XWr8fSk3w0rPsymbLpC410090	intact-crc:2B703C6CC94D9149|rigid:0MiicmfjfT+KmPhGPdO5hSJz/vs	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97767	uniprotkb:Q91WA6	intact:EBI-1368503|uniprotkb:G5E864|uniprotkb:O08818|ensembl:ENSMUSP00000027066|ensembl:ENSMUSP00000141112	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:eya1_mouse(display_long)|uniprotkb:Eya1(gene name)|psi-mi:Eya1(display_short)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6141059|imex:IM-17347-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001297388.1|refseq:XP_017170837.1|ensembl:ENSMUST00000190337(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007389"(pattern specification process)|go:"GO:0007501"(mesodermal cell fate specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045664"(regulation of neuron differentiation)|ensembl:ENSMUST00000027066(transcript)|ensembl:ENSMUSG00000025932(gene)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048752"(semicircular canal morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0071600"(otic vesicle morphogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0045739"(positive regulation of DNA repair)|interpro:IPR028471|interpro:IPR028472|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|interpro:IPR006545(EYA)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Figure 1D/E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/06/01	2014/10/16	rogid:uKPeKeQrf3qnLAV2fWPXVf9WVug10090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:B8B30B90852E8EAE|rigid:vAcL6/viW9QwXZUJcOK+52QrqKY	false	sufficient binding region:291-591	sufficient binding region:184-297	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08575	uniprotkb:Q91WA6	intact:EBI-986503|uniprotkb:P97925|ensembl:ENSMUSP00000066244|ensembl:ENSMUSP00000085455|uniprotkb:A2A5S4	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:eya2_mouse(display_long)|uniprotkb:Eya2(gene name)|psi-mi:Eya2(display_short)|uniprotkb:Eab1(gene name synonym)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Landgraf et al. (2010)	imex:IM-17347|pubmed:20956555	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6141006|imex:IM-17347-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017897(gene)|ensembl:ENSMUST00000063433(transcript)|ensembl:ENSMUST00000088132(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0048856"(anatomical structure development)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR006545(EYA)|interpro:IPR028472|interpro:IPR028473|interpro:IPR036412|interpro:IPR038102|interpro:IPR042577|reactome:R-MMU-5693565|refseq:NP_034295.1|refseq:NP_001258891.1|refseq:NP_001258892.1	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:Fig. 1D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/06/01	2014/10/16	rogid:pYM3Q0D4uhVNjMKJCatXk+1c92A10090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:D2171D8CBB2ADE2E|rigid:iUKn5wH9cC0iGsjorcCQ7Dc/kNQ	false	sufficient binding region:?-532	sufficient binding region:1-343	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)