#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q60598 uniprotkb:P33434 intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368 intact:EBI-6309886|ensembl:ENSMUSP00000034187 psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym) psi-mi:mmp2_mouse(display_long)|uniprotkb:Mmp2(gene name)|psi-mi:Mmp2(display_short)|uniprotkb:72 kDa gelatinase(gene name synonym)|uniprotkb:Gelatinase A(gene name synonym)|uniprotkb:Matrix metalloproteinase-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Banon-Rodriguez et al. (2011) pubmed:20952093|imex:IM-18786 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6309884|imex:IM-18786-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N ensembl:ENSMUSG00000031740(gene)|ensembl:ENSMUST00000034187(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0016477"(cell migration)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|go:"GO:0030017"(sarcomere)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028708|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|reactome:R-MMU-1442490|reactome:R-MMU-1474228|reactome:R-MMU-1592389|reactome:R-MMU-3928665|reactome:R-MMU-9009391|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|refseq:NP_032636.1 - - - figure legend:Fig 2F.|comment:"The Cortactin-WIP interaction was intact in the presence or absence of WIP (Fig 2F)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell) - 2012/10/04 2014/10/16 rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090 rogid:a1ImfZQsWm4WMOAMmoIvz3IZ+EI10090 intact-crc:78CB017D13259238|rigid:MgUcQI5k65xjx/PAB2eQ8MjUa5g false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)