#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48442	uniprotkb:P09216	intact:EBI-6140357|ensembl:ENSRNOP00000003092|ensembl:ENSRNOP00000069629|ensembl:ENSRNOP00000070633	intact:EBI-6049581	psi-mi:casr_rat(display_long)|uniprotkb:Casr(gene name)|psi-mi:Casr(display_short)|uniprotkb:Gprc2a(gene name synonym)|uniprotkb:Pcar1(gene name synonym)|uniprotkb:Parathyroid cell calcium-sensing receptor(gene name synonym)	psi-mi:kpce_rat(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dong et al. (2010)	pubmed:20383739|imex:IM-17339	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6140389|imex:IM-17339-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001296567.1|rgd:2277|refseq:NP_058692.1|refseq:XP_017453358.1|refseq:XP_017453359.1|refseq:XP_017453360.1|refseq:XP_017453361.1|ensembl:ENSRNOG00000002265(gene)|ensembl:ENSRNOT00000003092(transcript)|ensembl:ENSRNOT00000078341(transcript)|ensembl:ENSRNOT00000086097(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002931"(response to ischemia)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010038"(response to metal ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016597"(amino acid binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032782"(bile acid secretion)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042311"(vasodilation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060613"(fat pad development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070509"(calcium ion import)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071774"(response to fibroblast growth factor)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902476"(chloride transmembrane transport)|interpro:IPR000068(GPCR, family 3, extracellular calcium-sensing receptor-related)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-420499|go:"GO:0016323"(basolateral plasma membrane)	rgd:61925|refseq:NP_058867.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR027274|interpro:IPR035892|interpro:IPR034669|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:1GMI|reactome:R-RNO-114508|reactome:R-RNO-1250196|reactome:R-RNO-1489509|reactome:R-RNO-2029485|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051301"(cell division)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)	go:"GO:0005886"(plasma membrane)	-	-	figure legend:fig 1|agonist:Preconditioning of the cells to mimic ischemic conditions is required for the interaction to happen.|antagonist:"Inhibition of the activity of casr with NPS-2390 or that of prkce with chelerythrine chloride (100 microM) disrupts the interaction."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes_neo)|taxid:10116(rat cardiac myocytes neo)	-	2012/05/31	2014/10/16	rogid:7vAZSZmTrgzVjJDcupin7TNrv1410116	rogid:8KbTSbduZqvEsWszPkWFMQkprDk10116	intact-crc:BEDE8526F2F9493C|rigid:UIkkOR2oFSZ3qzNiQizhEutqis4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)