#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0AEJ4	uniprotkb:P42615	intact:EBI-1121750|uniprotkb:P02933|uniprotkb:Q2M769|ensemblbacteria:AAC76429|ensemblbacteria:BAE77887	intact:EBI-6412632|ensemblbacteria:AAC76131|ensemblbacteria:BAE77146|uniprotkb:Q2M9B0	psi-mi:envz_ecoli(display_long)|uniprotkb:Osmolarity sensor protein EnvZ(gene name synonym)|uniprotkb:envZ(gene name)|psi-mi:envZ(display_short)|uniprotkb:ompB(gene name synonym)|uniprotkb:perA(gene name synonym)|uniprotkb:tpo(gene name synonym)|uniprotkb:b3404(locus name)|uniprotkb:JW3367(locus name)	psi-mi:mzra_ecoli(display_long)|uniprotkb:mzrA(gene name)|psi-mi:mzrA(display_short)|uniprotkb:ecfM(gene name synonym)|uniprotkb:yqjB(gene name synonym)|uniprotkb:JW3067(locus name)|uniprotkb:b3096(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Gerken et al. (2009)	pubmed:19432797|imex:IM-18558	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6452597|imex:IM-18558-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001253696.1|ensemblbacteria:AAC76429(transcript)|ensemblbacteria:b3404(gene)|ensemblbacteria:BAE77887(gene)|ensemblbacteria:BAE77887(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0016310"(phosphorylation)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:1BXD|rcsb pdb:1JOY|rcsb pdb:1NJV|rcsb pdb:3ZCC|rcsb pdb:3ZRV|rcsb pdb:3ZRW|rcsb pdb:3ZRX|rcsb pdb:4CTI|rcsb pdb:4KP4|rcsb pdb:5B1N|rcsb pdb:5B1O|rcsb pdb:5XGA|refseq:NP_417863.1|dip:DIP-48357N	ensemblbacteria:AAC76131(transcript)|ensemblbacteria:b3096(gene)|ensemblbacteria:BAE77146(gene)|ensemblbacteria:BAE77146(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045859"(regulation of protein kinase activity)|refseq:WP_001166760.1|interpro:IPR026574|refseq:NP_417567.1|interpro:IPR027398	-	-	-	figure legend:Figure 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/12/10	2014/10/16	rogid:9sboPYQKBefVhBDHcDk7cBmYrZ883333	rogid:AK78fETJzDgdr5s+qrKoUU7qJE083333	intact-crc:038A23F6521E311B|rigid:dQ7qCjl75SxIWSUWJGwq3xvawsw	false	fusion protein:n-n	fusion protein:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42615	uniprotkb:P42615	intact:EBI-6412632|ensemblbacteria:AAC76131|ensemblbacteria:BAE77146|uniprotkb:Q2M9B0	intact:EBI-6412632|ensemblbacteria:AAC76131|ensemblbacteria:BAE77146|uniprotkb:Q2M9B0	psi-mi:mzra_ecoli(display_long)|uniprotkb:mzrA(gene name)|psi-mi:mzrA(display_short)|uniprotkb:ecfM(gene name synonym)|uniprotkb:yqjB(gene name synonym)|uniprotkb:JW3067(locus name)|uniprotkb:b3096(locus name)	psi-mi:mzra_ecoli(display_long)|uniprotkb:mzrA(gene name)|psi-mi:mzrA(display_short)|uniprotkb:ecfM(gene name synonym)|uniprotkb:yqjB(gene name synonym)|uniprotkb:JW3067(locus name)|uniprotkb:b3096(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Gerken et al. (2009)	pubmed:19432797|imex:IM-18558	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6452624|imex:IM-18558-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAC76131(transcript)|ensemblbacteria:b3096(gene)|ensemblbacteria:BAE77146(gene)|ensemblbacteria:BAE77146(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045859"(regulation of protein kinase activity)|refseq:WP_001166760.1|interpro:IPR026574|refseq:NP_417567.1|interpro:IPR027398	ensemblbacteria:AAC76131(transcript)|ensemblbacteria:b3096(gene)|ensemblbacteria:BAE77146(gene)|ensemblbacteria:BAE77146(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045859"(regulation of protein kinase activity)|refseq:WP_001166760.1|interpro:IPR026574|refseq:NP_417567.1|interpro:IPR027398	-	-	-	figure legend:Figure 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/12/10	2014/10/16	rogid:AK78fETJzDgdr5s+qrKoUU7qJE083333	rogid:AK78fETJzDgdr5s+qrKoUU7qJE083333	intact-crc:F959309962A62BB2|rigid:FZsfBmL2PfXMo3jcE5Ar8RXnq3g	false	fusion protein:n-n	fusion protein:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEJ4	uniprotkb:P42615	intact:EBI-1121750|uniprotkb:P02933|uniprotkb:Q2M769|ensemblbacteria:AAC76429|ensemblbacteria:BAE77887	intact:EBI-6412632|ensemblbacteria:AAC76131|ensemblbacteria:BAE77146|uniprotkb:Q2M9B0	psi-mi:envz_ecoli(display_long)|uniprotkb:Osmolarity sensor protein EnvZ(gene name synonym)|uniprotkb:envZ(gene name)|psi-mi:envZ(display_short)|uniprotkb:ompB(gene name synonym)|uniprotkb:perA(gene name synonym)|uniprotkb:tpo(gene name synonym)|uniprotkb:b3404(locus name)|uniprotkb:JW3367(locus name)	psi-mi:mzra_ecoli(display_long)|uniprotkb:mzrA(gene name)|psi-mi:mzrA(display_short)|uniprotkb:ecfM(gene name synonym)|uniprotkb:yqjB(gene name synonym)|uniprotkb:JW3067(locus name)|uniprotkb:b3096(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Gerken et al. (2009)	pubmed:19432797|imex:IM-18558	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6446702|imex:IM-18558-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001253696.1|ensemblbacteria:AAC76429(transcript)|ensemblbacteria:b3404(gene)|ensemblbacteria:BAE77887(gene)|ensemblbacteria:BAE77887(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0016310"(phosphorylation)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:1BXD|rcsb pdb:1JOY|rcsb pdb:1NJV|rcsb pdb:3ZCC|rcsb pdb:3ZRV|rcsb pdb:3ZRW|rcsb pdb:3ZRX|rcsb pdb:4CTI|rcsb pdb:4KP4|rcsb pdb:5B1N|rcsb pdb:5B1O|rcsb pdb:5XGA|refseq:NP_417863.1|dip:DIP-48357N	ensemblbacteria:AAC76131(transcript)|ensemblbacteria:b3096(gene)|ensemblbacteria:BAE77146(gene)|ensemblbacteria:BAE77146(transcript)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0045859"(regulation of protein kinase activity)|refseq:WP_001166760.1|interpro:IPR026574|refseq:NP_417567.1|interpro:IPR027398	-	-	-	figure legend:Figure 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/12/10	2014/10/16	rogid:9sboPYQKBefVhBDHcDk7cBmYrZ883333	rogid:AK78fETJzDgdr5s+qrKoUU7qJE083333	intact-crc:F0A8F6AD3F9B22AA|rigid:dQ7qCjl75SxIWSUWJGwq3xvawsw	false	fusion protein:c-c	fusion protein:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEJ4	uniprotkb:P0AEJ4	intact:EBI-1121750|uniprotkb:P02933|uniprotkb:Q2M769|ensemblbacteria:AAC76429|ensemblbacteria:BAE77887	intact:EBI-1121750|uniprotkb:P02933|uniprotkb:Q2M769|ensemblbacteria:AAC76429|ensemblbacteria:BAE77887	psi-mi:envz_ecoli(display_long)|uniprotkb:Osmolarity sensor protein EnvZ(gene name synonym)|uniprotkb:envZ(gene name)|psi-mi:envZ(display_short)|uniprotkb:ompB(gene name synonym)|uniprotkb:perA(gene name synonym)|uniprotkb:tpo(gene name synonym)|uniprotkb:b3404(locus name)|uniprotkb:JW3367(locus name)	psi-mi:envz_ecoli(display_long)|uniprotkb:Osmolarity sensor protein EnvZ(gene name synonym)|uniprotkb:envZ(gene name)|psi-mi:envZ(display_short)|uniprotkb:ompB(gene name synonym)|uniprotkb:perA(gene name synonym)|uniprotkb:tpo(gene name synonym)|uniprotkb:b3404(locus name)|uniprotkb:JW3367(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Gerken et al. (2009)	pubmed:19432797|imex:IM-18558	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6452632|imex:IM-18558-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001253696.1|ensemblbacteria:AAC76429(transcript)|ensemblbacteria:b3404(gene)|ensemblbacteria:BAE77887(gene)|ensemblbacteria:BAE77887(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0016310"(phosphorylation)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:1BXD|rcsb pdb:1JOY|rcsb pdb:1NJV|rcsb pdb:3ZCC|rcsb pdb:3ZRV|rcsb pdb:3ZRW|rcsb pdb:3ZRX|rcsb pdb:4CTI|rcsb pdb:4KP4|rcsb pdb:5B1N|rcsb pdb:5B1O|rcsb pdb:5XGA|refseq:NP_417863.1|dip:DIP-48357N	refseq:WP_001253696.1|ensemblbacteria:AAC76429(transcript)|ensemblbacteria:b3404(gene)|ensemblbacteria:BAE77887(gene)|ensemblbacteria:BAE77887(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0016310"(phosphorylation)|go:"GO:0018106"(peptidyl-histidine phosphorylation)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003660(Signal transduction histidine kinase, HAMP region)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:1BXD|rcsb pdb:1JOY|rcsb pdb:1NJV|rcsb pdb:3ZCC|rcsb pdb:3ZRV|rcsb pdb:3ZRW|rcsb pdb:3ZRX|rcsb pdb:4CTI|rcsb pdb:4KP4|rcsb pdb:5B1N|rcsb pdb:5B1O|rcsb pdb:5XGA|refseq:NP_417863.1|dip:DIP-48357N	-	-	-	figure legend:Figure 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/12/10	2014/10/16	rogid:9sboPYQKBefVhBDHcDk7cBmYrZ883333	rogid:9sboPYQKBefVhBDHcDk7cBmYrZ883333	intact-crc:B1F5AD5653D52558|rigid:m2MCpXTuyw0HJ510ptqttPFgBVA	false	fusion protein:n-n	fusion protein:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)