#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21865	uniprotkb:P21866	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	intact:EBI-6403634|ensemblbacteria:AAC73788|ensemblbacteria:BAA35351|uniprotkb:P76822|uniprotkb:P75739	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:kdpe_ecoli(display_long)|uniprotkb:JW5096(locus name)|uniprotkb:b0694(locus name)|uniprotkb:kdpE(gene name)|psi-mi:kdpE(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6511912|mpidb:MPIDB-INT-711|imex:IM-18287-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0842"(phosphate donor)	psi-mi:"MI:1085"(photon acceptor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	ensemblbacteria:AAC73788(transcript)|ensemblbacteria:b0694(gene)|ensemblbacteria:BAA35351(gene)|ensemblbacteria:BAA35351(transcript)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000986"|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011006(CheY-like)|interpro:IPR036388|interpro:IPR039420|rcsb pdb:1ZH2|refseq:WP_000186076.1|rcsb pdb:3ZQ7|rcsb pdb:4KFC|rcsb pdb:4KNY|rcsb pdb:4L85|rcsb pdb:1ZH4|refseq:NP_415222.1|dip:DIP-10063N	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rogid:pYO0+R6xjtBBuo/zrfbFn5kzxbM83333	intact-crc:36E78A829DDDB121|rigid:P6ddpYgueEsDFJBsVpedz4s4A7s	false	his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P21865	uniprotkb:P69829	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	intact:EBI-547017|uniprotkb:P31222|uniprotkb:Q2M908|ensemblbacteria:AAC76236|ensemblbacteria:BAE77248	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:ptsn_ecoli(display_long)|uniprotkb:ptsN(gene name)|psi-mi:ptsN(display_short)|uniprotkb:rpoP(gene name synonym)|uniprotkb:b3204(locus name)|uniprotkb:yhbI(gene name synonym)|uniprotkb:Enzyme IIA-NTR(gene name synonym)|uniprotkb:Phosphotransferase enzyme IIA component(gene name synonym)|uniprotkb:PTS system EIIA component(gene name synonym)|uniprotkb:JW3171(locus name)	psi-mi:"MI:0841"(phosphotransferase assay)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6511912|mpidb:MPIDB-INT-711|imex:IM-18287-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0842"(phosphate donor)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	refseq:NP_417671.1|ensemblbacteria:AAC76236(transcript)|ensemblbacteria:b3204(gene)|ensemblbacteria:BAE77248(gene)|ensemblbacteria:BAE77248(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0008982"("protein-N(PI)-phosphohistidine-sugar phosphotransferase activity")|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016301"(kinase activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|interpro:IPR002178(Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2)|interpro:IPR006320(Phosphotransferase system, IIA-like nitrogen-regulatory protein PtsN)|interpro:IPR016152(Phosphotransferase/anion transporter)|rcsb pdb:1A6J|refseq:WP_000183676.1|dip:DIP-10604N	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rogid:xeiRUpgqK0ECScs8/RMJWKroZ2A83333	intact-crc:36E78A829DDDB121|rigid:P6ddpYgueEsDFJBsVpedz4s4A7s	false	his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P21865	uniprotkb:P21866	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	intact:EBI-6403634|ensemblbacteria:AAC73788|ensemblbacteria:BAA35351|uniprotkb:P76822|uniprotkb:P75739	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:kdpe_ecoli(display_long)|uniprotkb:JW5096(locus name)|uniprotkb:b0694(locus name)|uniprotkb:kdpE(gene name)|psi-mi:kdpE(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6407718|mpidb:MPIDB-INT-711|imex:IM-18287-2	-	-	psi-mi:"MI:0842"(phosphate donor)	psi-mi:"MI:1085"(photon acceptor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	ensemblbacteria:AAC73788(transcript)|ensemblbacteria:b0694(gene)|ensemblbacteria:BAA35351(gene)|ensemblbacteria:BAA35351(transcript)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000986"|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011006(CheY-like)|interpro:IPR036388|interpro:IPR039420|rcsb pdb:1ZH2|refseq:WP_000186076.1|rcsb pdb:3ZQ7|rcsb pdb:4KFC|rcsb pdb:4KNY|rcsb pdb:4L85|rcsb pdb:1ZH4|refseq:NP_415222.1|dip:DIP-10063N	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rogid:pYO0+R6xjtBBuo/zrfbFn5kzxbM83333	intact-crc:09F16A70723002C3|rigid:UB+nh3Y3sUDnkZN0O0qZ3F0Gqe4	false	N-phosphorylated residue:?-?|his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P21865	uniprotkb:P21866	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	intact:EBI-6403634|ensemblbacteria:AAC73788|ensemblbacteria:BAA35351|uniprotkb:P76822|uniprotkb:P75739	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:kdpe_ecoli(display_long)|uniprotkb:JW5096(locus name)|uniprotkb:b0694(locus name)|uniprotkb:kdpE(gene name)|psi-mi:kdpE(display_short)	psi-mi:"MI:0841"(phosphotransferase assay)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6407728|mpidb:MPIDB-INT-713|imex:IM-18287-4	-	-	psi-mi:"MI:1085"(photon acceptor)	psi-mi:"MI:1084"(photon donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	ensemblbacteria:AAC73788(transcript)|ensemblbacteria:b0694(gene)|ensemblbacteria:BAA35351(gene)|ensemblbacteria:BAA35351(transcript)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000986"|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011006(CheY-like)|interpro:IPR036388|interpro:IPR039420|rcsb pdb:1ZH2|refseq:WP_000186076.1|rcsb pdb:3ZQ7|rcsb pdb:4KFC|rcsb pdb:4KNY|rcsb pdb:4L85|rcsb pdb:1ZH4|refseq:NP_415222.1|dip:DIP-10063N	-	-	-	figure legend:Fig. 6, 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rogid:pYO0+R6xjtBBuo/zrfbFn5kzxbM83333	intact-crc:9AD4866D605CDD93|rigid:UB+nh3Y3sUDnkZN0O0qZ3F0Gqe4	false	his tag:c-c	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P21865	-	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	-	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	-	psi-mi:"MI:0841"(phosphotransferase assay)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6511895|imex:IM-18287-6	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	-	-	-	-	figure legend:Figs. 6, 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	-	intact-crc:99D749EA578D26A1	false	his tag:c-c	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:P69829	uniprotkb:P21865	intact:EBI-547017|uniprotkb:P31222|uniprotkb:Q2M908|ensemblbacteria:AAC76236|ensemblbacteria:BAE77248	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	psi-mi:ptsn_ecoli(display_long)|uniprotkb:ptsN(gene name)|psi-mi:ptsN(display_short)|uniprotkb:rpoP(gene name synonym)|uniprotkb:b3204(locus name)|uniprotkb:yhbI(gene name synonym)|uniprotkb:Enzyme IIA-NTR(gene name synonym)|uniprotkb:Phosphotransferase enzyme IIA component(gene name synonym)|uniprotkb:PTS system EIIA component(gene name synonym)|uniprotkb:JW3171(locus name)	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:"MI:0841"(phosphotransferase assay)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6511898|imex:IM-18287-7	-	-	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417671.1|ensemblbacteria:AAC76236(transcript)|ensemblbacteria:b3204(gene)|ensemblbacteria:BAE77248(gene)|ensemblbacteria:BAE77248(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0008982"("protein-N(PI)-phosphohistidine-sugar phosphotransferase activity")|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016301"(kinase activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|interpro:IPR002178(Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2)|interpro:IPR006320(Phosphotransferase system, IIA-like nitrogen-regulatory protein PtsN)|interpro:IPR016152(Phosphotransferase/anion transporter)|rcsb pdb:1A6J|refseq:WP_000183676.1|dip:DIP-10604N	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	-	-	-	figure legend:Figs. 6, 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:xeiRUpgqK0ECScs8/RMJWKroZ2A83333	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	intact-crc:325B9DD21C01F8F3|rigid:b+IbNJWlO+VhFk6tvb8k7eSl3/k	false	his tag:n-n	his tag:c-c	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P21865	uniprotkb:P21865	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6511862|mpidb:MPIDB-INT-712|imex:IM-18287-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	-	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	intact-crc:D499EA229BD19580|rigid:sXexu+HM7VNBphM/XCoDdwVT6Jo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21865	uniprotkb:P21866	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	intact:EBI-6403634|ensemblbacteria:AAC73788|ensemblbacteria:BAA35351|uniprotkb:P76822|uniprotkb:P75739	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:kdpe_ecoli(display_long)|uniprotkb:JW5096(locus name)|uniprotkb:b0694(locus name)|uniprotkb:kdpE(gene name)|psi-mi:kdpE(display_short)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6407713|mpidb:MPIDB-INT-712|imex:IM-18287-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	ensemblbacteria:AAC73788(transcript)|ensemblbacteria:b0694(gene)|ensemblbacteria:BAA35351(gene)|ensemblbacteria:BAA35351(transcript)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000986"|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011006(CheY-like)|interpro:IPR036388|interpro:IPR039420|rcsb pdb:1ZH2|refseq:WP_000186076.1|rcsb pdb:3ZQ7|rcsb pdb:4KFC|rcsb pdb:4KNY|rcsb pdb:4L85|rcsb pdb:1ZH4|refseq:NP_415222.1|dip:DIP-10063N	-	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/11/30	2014/10/16	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	rogid:pYO0+R6xjtBBuo/zrfbFn5kzxbM83333	intact-crc:AF500A334C015842|rigid:UB+nh3Y3sUDnkZN0O0qZ3F0Gqe4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P69829	uniprotkb:P21865	intact:EBI-547017|uniprotkb:P31222|uniprotkb:Q2M908|ensemblbacteria:AAC76236|ensemblbacteria:BAE77248	intact:EBI-1123100|ensemblbacteria:AAC73789|ensemblbacteria:BAA35352	psi-mi:ptsn_ecoli(display_long)|uniprotkb:ptsN(gene name)|psi-mi:ptsN(display_short)|uniprotkb:rpoP(gene name synonym)|uniprotkb:b3204(locus name)|uniprotkb:yhbI(gene name synonym)|uniprotkb:Enzyme IIA-NTR(gene name synonym)|uniprotkb:Phosphotransferase enzyme IIA component(gene name synonym)|uniprotkb:PTS system EIIA component(gene name synonym)|uniprotkb:JW3171(locus name)	psi-mi:kdpd_ecoli(display_long)|uniprotkb:kdpD(gene name)|psi-mi:kdpD(display_short)|uniprotkb:b0695(locus name)|uniprotkb:JW0683(locus name)	psi-mi:"MI:0014"(adenylate cyclase complementation)	Lüttmann et al. (2009)	pubmed:19400808|imex:IM-18287	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6407723|mpidb:MPIDB-INT-710|imex:IM-18287-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417671.1|ensemblbacteria:AAC76236(transcript)|ensemblbacteria:b3204(gene)|ensemblbacteria:BAE77248(gene)|ensemblbacteria:BAE77248(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005829"(cytosol)|go:"GO:0008982"("protein-N(PI)-phosphohistidine-sugar phosphotransferase activity")|go:"GO:0009401"(phosphoenolpyruvate-dependent sugar phosphotransferase system)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0016301"(kinase activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|interpro:IPR002178(Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2)|interpro:IPR006320(Phosphotransferase system, IIA-like nitrogen-regulatory protein PtsN)|interpro:IPR016152(Phosphotransferase/anion transporter)|rcsb pdb:1A6J|refseq:WP_000183676.1|dip:DIP-10604N	refseq:WP_001310640.1|ensemblbacteria:AAC73789(transcript)|ensemblbacteria:b0695(gene)|ensemblbacteria:BAA35352(gene)|ensemblbacteria:BAA35352(transcript)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0071472"(cellular response to salt stress)|interpro:IPR003018(GAF)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR003852(Signal transduction histidine kinase, osmosensitive K+ channel sensor, N-terminal)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR025201|interpro:IPR027417|interpro:IPR029016|interpro:IPR036097|interpro:IPR036890|interpro:IPR038318|rcsb pdb:2KSF|rcsb pdb:4QPR|rcsb pdb:4Y2F|go:"GO:0009593"(detection of chemical stimulus)|refseq:NP_415223.1|dip:DIP-10062N	-	-	-	figure legend:Fig. 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2012/11/30	2014/10/16	rogid:xeiRUpgqK0ECScs8/RMJWKroZ2A83333	rogid:s6VUEMpZNKiBCumtZL52LM+kt2s83333	intact-crc:BB1EF9794A762C03|rigid:b+IbNJWlO+VhFk6tvb8k7eSl3/k	false	mutation increasing interaction strength:73-73	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)