#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P42858	uniprotkb:Q13177	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Luo et al. (2009)	pubmed:19240112|imex:IM-17043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327199|imex:IM-17043-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	-	-	-	figure legend:S2|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/17	2014/10/16	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	intact-crc:8F464A32528F26D8|rigid:xk3eqsQGIteGaQ+XwsV3B2k41UM	false	flag tag:n-n|sufficient binding region:1-547	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CIN4	uniprotkb:P42858	intact:EBI-1559317|ensembl:ENSMUSP00000023467	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:pak2_mouse(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:Pak2(gene name)|psi-mi:Pak2(display_short)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Luo et al. (2009)	pubmed:19240112|imex:IM-17043	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327215|imex:IM-17043-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_796300.1|refseq:XP_006522135.1|dip:DIP-39167N|ensembl:ENSMUSG00000022781(gene)|ensembl:ENSMUST00000023467(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q8CIN4|reactome:R-MMU-202433|reactome:R-MMU-2871796|reactome:R-MMU-389359|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:S6a|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/17	2014/10/16	rogid:5J6RxkZotYPD92E0NgUv+ADI+HA10090	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	intact-crc:A1A71EAE0437C7B8|rigid:qW6/LPbOUaAOc9jlw5x+A1+gWn0	false	myc tag:n-n	sufficient binding region:1-547|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13177	uniprotkb:P42858	intact:EBI-1045887|uniprotkb:Q13154|uniprotkb:Q6ISC3|ensembl:ENSP00000314067|intact:EBI-28976120	intact:EBI-466029|uniprotkb:Q9UQB7|ensembl:ENSP00000347184	psi-mi:pak2_human(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:PAK65(gene name synonym)|uniprotkb:S6/H4 kinase(gene name synonym)|uniprotkb:p58(gene name synonym)|uniprotkb:PAK2(gene name)|psi-mi:PAK2(display_short)	psi-mi:hd_human(display_long)|uniprotkb:HTT(gene name)|psi-mi:HTT(display_short)|uniprotkb:IT15(gene name synonym)|uniprotkb:HD(gene name synonym)|uniprotkb:Huntington disease protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Luo et al. (2009)	pubmed:19240112|imex:IM-17043	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327169|imex:IM-17043-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000314067|ensembl:ENSG00000180370(gene)|ensembl:ENST00000327134(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q13177|rcsb pdb:3PCS|reactome:R-HSA-164944|reactome:R-HSA-202433|reactome:R-HSA-211728|reactome:R-HSA-211733|reactome:R-HSA-211736|reactome:R-HSA-2871796|reactome:R-HSA-389359|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-445355|reactome:R-HSA-5621575|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-5218920|refseq:NP_002568.2|refseq:XP_011511172.1|refseq:XP_016861990.1|dip:DIP-38249N	ensembl:ENSG00000197386(gene)|refseq:NP_002102.4|rcsb pdb:3IOV|rcsb pdb:3IOW|rcsb pdb:3LRH|rcsb pdb:4FE8|rcsb pdb:4FEB|rcsb pdb:4FEC|rcsb pdb:4FED|rcsb pdb:4RAV|rcsb pdb:6EZ8|rcsb pdb:6N8C|rcsb pdb:6RMH|rcsb pdb:6X9O|rcsb pdb:6YEJ|rcsb pdb:7DXJ|rcsb pdb:7DXK|reactome:R-HSA-9022692|ensembl:ENST00000355072(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006915"(apoptotic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0016234"(inclusion body)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0042297"(vocal learning)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000132"(establishment of mitotic spindle orientation)|interpro:IPR024613|interpro:IPR028426|mint:P42858|rcsb pdb:2D3X|rcsb pdb:2LD0|rcsb pdb:2LD2|rcsb pdb:3IO4|rcsb pdb:3IO6|rcsb pdb:3IOR|rcsb pdb:3IOT|rcsb pdb:3IOU|dip:DIP-32492N	-	-	-	figure legend:1a, 1b, 4a and 4b|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/01/17	2014/10/16	rogid:BLFG1UZy6GUy26Hd7VDehsIq3/I9606	rogid:KyttHE2o2fORsw6iTh94LB7QShA9606	intact-crc:B3045DC7494433D6|rigid:xk3eqsQGIteGaQ+XwsV3B2k41UM	false	myc tag:n-n	flag tag:n-n|mutation decreasing interaction:1-547..547|sufficient binding region:1-547|necessary binding region:1-185	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CIN4	uniprotkb:P42859	intact:EBI-1559317|ensembl:ENSMUSP00000023467	intact:EBI-5327353	psi-mi:pak2_mouse(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:Pak2(gene name)|psi-mi:Pak2(display_short)	psi-mi:hd_mouse(display_long)|uniprotkb:Htt(gene name)|psi-mi:Htt(display_short)|uniprotkb:Hd(gene name synonym)|uniprotkb:Hdh(gene name synonym)|uniprotkb:Huntington disease protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Luo et al. (2009)	pubmed:19240112|imex:IM-17043	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327412|imex:IM-17043-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_796300.1|refseq:XP_006522135.1|dip:DIP-39167N|ensembl:ENSMUSG00000022781(gene)|ensembl:ENSMUST00000023467(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q8CIN4|reactome:R-MMU-202433|reactome:R-MMU-2871796|reactome:R-MMU-389359|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	mint:P42859|dip:DIP-41430N|go:"GO:0000050"(urea cycle)|go:"GO:0000052"(citrulline metabolic process)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007369"(gastrulation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0007569"(cell aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008306"(associative learning)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008542"(visual learning)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019805"(quinolinate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021756"(striatum development)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0021990"(neural plate formation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0030073"(insulin secretion)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048666"(neuron development)|go:"GO:0050809"(diazepam binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904580"(regulation of intracellular mRNA localization)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:1905505"(positive regulation of motile cilium assembly)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024613|interpro:IPR028426	-	-	-	figure legend:1c|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2012/01/17	2014/10/16	rogid:5J6RxkZotYPD92E0NgUv+ADI+HA10090	rogid:Jnwg1bcRyps/kq4nMWqPwjVFF9c10090	intact-crc:EB412501059B7314|rigid:29/LlWZ6h3Fod+gtvOM62EEv244	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CIN4	uniprotkb:P42859	intact:EBI-1559317|ensembl:ENSMUSP00000023467	intact:EBI-5327353	psi-mi:pak2_mouse(display_long)|uniprotkb:p21-activated kinase 2(gene name synonym)|uniprotkb:Gamma-PAK(gene name synonym)|uniprotkb:Pak2(gene name)|psi-mi:Pak2(display_short)	psi-mi:hd_mouse(display_long)|uniprotkb:Htt(gene name)|psi-mi:Htt(display_short)|uniprotkb:Hd(gene name synonym)|uniprotkb:Hdh(gene name synonym)|uniprotkb:Huntington disease protein homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Luo et al. (2009)	pubmed:19240112|imex:IM-17043	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-5327416|imex:IM-17043-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_796300.1|refseq:XP_006522135.1|dip:DIP-39167N|ensembl:ENSMUSG00000022781(gene)|ensembl:ENSMUST00000023467(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR035064|interpro:IPR035065|interpro:IPR036936|mint:Q8CIN4|reactome:R-MMU-202433|reactome:R-MMU-2871796|reactome:R-MMU-389359|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-4420097|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	mint:P42859|dip:DIP-41430N|go:"GO:0000050"(urea cycle)|go:"GO:0000052"(citrulline metabolic process)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007369"(gastrulation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005522"(profilin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0007569"(cell aging)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007625"(grooming behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008306"(associative learning)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008542"(visual learning)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019805"(quinolinate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021756"(striatum development)|go:"GO:0021988"(olfactory lobe development)|go:"GO:0021990"(neural plate formation)|go:"GO:0022008"(neurogenesis)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0030073"(insulin secretion)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031587"(positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034452"(dynactin binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0042297"(vocal learning)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048341"(paraxial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048666"(neuron development)|go:"GO:0050809"(diazepam binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099111"(microtubule-based transport)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904580"(regulation of intracellular mRNA localization)|go:"GO:1905289"(regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905337"(positive regulation of aggrephagy)|go:"GO:1905505"(positive regulation of motile cilium assembly)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000479"(regulation of cAMP-dependent protein kinase activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000091(Huntingtin)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024613|interpro:IPR028426	-	-	-	figure legend:1d and S1|dataset:Huntington's - Publications describing interactions involved in Huntington's disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2012/01/17	2014/10/16	rogid:5J6RxkZotYPD92E0NgUv+ADI+HA10090	rogid:Jnwg1bcRyps/kq4nMWqPwjVFF9c10090	intact-crc:A41F34273C8E7B0D|rigid:29/LlWZ6h3Fod+gtvOM62EEv244	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)