#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109337|imex:IM-20569-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:4BA82596987B1824|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109296|imex:IM-20569-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 1B/S1|antagonist:lambda phosphatase|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:E1DE6A330AAB2B34|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	mutation disrupting interaction:23-23|glutathione s tranferase tag:?-?|sufficient binding region:1-40	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46531	uniprotkb:Q13526	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0096"(pull down)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109330|imex:IM-20569-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:Fig 1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:4BA919F567052924|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109343|imex:IM-20569-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 1B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:4BA843C0A18D1824|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109367|imex:IM-20569-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 1C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skbr3)|taxid:9606(Homo sapiens SKBR3)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:5283D45AB93EE74A|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109386|imex:IM-20569-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 1C|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skbr3)|taxid:9606(Homo sapiens SKBR3)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:9517E9149F0900DA|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109405|imex:IM-20569-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 1B|comment:"The N1deltaE -Flag construct contains the Notch1 signal peptide and  the intracellular domain. (deletion of  most of the ECD)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:34B75EA63F5C5CDF|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	glutathione s tranferase tag:?-?	ha tag:1731-1731|binding-associated region:1-23,1715-2555|flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46531	uniprotkb:Q13526	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0096"(pull down)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109584|imex:IM-20569-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	-	-	-	figure legend:Fig 4 D/E|comment:"The N1deltaE -Flag construct contains the Notch1 signal peptide and  the intracellular domain. (deletion of  most of the ECD)."|antagonist:MAP/SAPK inhibitors.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	intact-crc:70A4DFD611F4CDB9|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	binding-associated region:1-23,1715-2171|binding-associated region:2120-2555|myc tag:c-c|mutation decreasing interaction strength:2121-2121,2132-2132,2136-2136|mutation disrupting interaction strength:2121-2121,2132-2132,2136-2136,2141-2141	sufficient binding region:5..5-39..39|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13526	uniprotkb:P46531	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109434|imex:IM-20569-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 4 A/B|comment:"The N1deltaE -Flag construct contains the Notch1 signal peptide and  the intracellular domain. (deletion of  most of the ECD)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/04/25	2014/10/16	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:239F242C31401536|rigid:JlJ1Wdgnju+5iKp3T/U+ePhPrys	false	sufficient binding region:5..5-39..39|glutathione s tranferase tag:?-?	binding-associated region:1-23,1715-2555|myc tag:c-c|binding-associated region:2120-2555	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P46531	ensembl:ENSG00000114315	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	intact:EBI-6109761	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:hes1_human_gene(display_short)|psi-mi:ENSG00000114315(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109739|imex:IM-20569-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	-	figure legend:Fig 6D|antagonist:gamma-secretase inhibitor|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2012/04/25	2014/10/16	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	-	intact-crc:7F393B62FEE42435	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSG00000127445	uniprotkb:P46531	intact:EBI-6109742	intact:EBI-636374|uniprotkb:Q59ED8|uniprotkb:Q5SXM3|intact:EBI-28989124|ensembl:ENSP00000498587	psi-mi:pin1_human_gene(display_short)|psi-mi:ENSG00000127445(display_long)	psi-mi:notc1_human(display_long)|uniprotkb:Translocation-associated notch protein TAN-1(gene name synonym)|uniprotkb:NOTCH1(gene name)|psi-mi:NOTCH1(display_short)|uniprotkb:TAN1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Rustighi et al. (2009)	pubmed:19151708|imex:IM-20569	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6109771|imex:IM-20569-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_060087.3|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0005912"(adherens junction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007411"(axon guidance)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|go:"GO:0070986"(left/right axis specification)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|interpro:IPR035993|interpro:IPR036770|mint:P46531|rcsb pdb:1PB5|rcsb pdb:1TOZ|rcsb pdb:1YYH|rcsb pdb:2F8X|rcsb pdb:2F8Y|rcsb pdb:2HE0|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|rcsb pdb:2VJ3|rcsb pdb:3ETO|rcsb pdb:3I08|rcsb pdb:3L95|rcsb pdb:3NBN|rcsb pdb:3V79|rcsb pdb:4CUD|rcsb pdb:4CUE|rcsb pdb:4CUF|rcsb pdb:4D0E|rcsb pdb:4D0F|rcsb pdb:5FM9|rcsb pdb:5FMA|rcsb pdb:5KZO|rcsb pdb:5L0R|rcsb pdb:5UB5|rcsb pdb:6IDF|rcsb pdb:6PY8|reactome:R-HSA-1912399|reactome:R-HSA-1912408|reactome:R-HSA-1912420|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-5083630|reactome:R-HSA-8941856|reactome:R-HSA-9013508|reactome:R-HSA-9013695|ensembl:ENSG00000148400(gene)|ensembl:ENST00000651671(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|dip:DIP-29919N|ensembl:ENSP00000498587	-	-	-	figure legend:Fig 6D|antagonist:gamma-secretase inhibitor|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2012/04/25	2014/10/16	-	rogid:yRAjMjynnyZ7ANlk2eulodpS4P09606	intact-crc:729911605FAFE232	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)