#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q2TV77 uniprotkb:P09486 intact:EBI-6405263 intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061 psi-mi:q2tv77_finma(display_long)|uniprotkb:faf(gene name)|psi-mi:faf(display_short) psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short) psi-mi:"MI:0040"(electron microscopy) Frick et al. (2008) pubmed:18808384|imex:IM-18235 taxid:1260(pepma)|taxid:1260(Peptostreptococcus magnus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6405689|imex:IM-18235-8|mpidb:MPIDB-INT-616 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033764|interpro:IPR019931 refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N - - - figure legend:Fig. 6C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:x26dbTkLnV/GAmJv6yxOVNEBE6Q1260 rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606 intact-crc:0925C6A76A25D90B|rigid:LQghCovuyvuFy+AxBONG529rx54 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09486 uniprotkb:Q2TV77 intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061 intact:EBI-6405263 psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short) psi-mi:q2tv77_finma(display_long)|uniprotkb:faf(gene name)|psi-mi:faf(display_short) psi-mi:"MI:0040"(electron microscopy) Frick et al. (2008) pubmed:18808384|imex:IM-18235 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:1260(pepma)|taxid:1260(Peptostreptococcus magnus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6405734|imex:IM-18235-9|mpidb:MPIDB-INT-616 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033764|interpro:IPR019931 - - - figure legend:Fig. 6C|comment:GST tag used to locate the N-terminus of the molecule, BM40 could then be seen to bind to the C-terminus.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606 rogid:x26dbTkLnV/GAmJv6yxOVNEBE6Q1260 intact-crc:AA1C234A9E7A2358|rigid:LQghCovuyvuFy+AxBONG529rx54 false - glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TV77 uniprotkb:P09486 intact:EBI-6405263 intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061 psi-mi:q2tv77_finma(display_long)|uniprotkb:faf(gene name)|psi-mi:faf(display_short) psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Frick et al. (2008) pubmed:18808384|imex:IM-18235 taxid:1260(pepma)|taxid:1260(Peptostreptococcus magnus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6404524|mpidb:MPIDB-INT-616|imex:IM-18235-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033764|interpro:IPR019931 refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N - - - figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-9(molar) 2012/11/30 2014/10/16 rogid:x26dbTkLnV/GAmJv6yxOVNEBE6Q1260 rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606 intact-crc:D10BC856263710D2|rigid:LQghCovuyvuFy+AxBONG529rx54 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q2TV77 uniprotkb:P09486 intact:EBI-6405263 intact:EBI-2800983|uniprotkb:Q6IBK4|uniprotkb:D3DQH9|ensembl:ENSP00000231061 psi-mi:q2tv77_finma(display_long)|uniprotkb:faf(gene name)|psi-mi:faf(display_short) psi-mi:sprc_human(display_long)|uniprotkb:ON(gene name synonym)|uniprotkb:Basement-membrane protein 40(gene name synonym)|uniprotkb:Osteonectin(gene name synonym)|uniprotkb:Secreted protein acidic and rich in cysteine(gene name synonym)|uniprotkb:SPARC(gene name)|psi-mi:SPARC(display_short) psi-mi:"MI:0047"(far western blotting) Frick et al. (2008) pubmed:18808384|imex:IM-18235 taxid:1260(pepma)|taxid:1260(Peptostreptococcus magnus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6405596|imex:IM-18235-7|mpidb:MPIDB-INT-616 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033764|interpro:IPR019931 refseq:NP_001296372.1|refseq:NP_001296373.1|refseq:NP_003109.1|ensembl:ENSG00000113140(gene)|ensembl:ENST00000231061(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0009629"(response to gravity)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030324"(lung development)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034097"(response to cytokine)|go:"GO:0042060"(wound healing)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048839"(inner ear development)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|interpro:IPR037641|rcsb pdb:1BMO|rcsb pdb:1NUB|rcsb pdb:1SRA|rcsb pdb:2V53|reactome:R-HSA-114608|reactome:R-HSA-1251985|reactome:R-HSA-3000178|reactome:R-HSA-3000497|dip:DIP-46426N - - - figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-9(molar) 2012/11/30 2014/10/16 rogid:x26dbTkLnV/GAmJv6yxOVNEBE6Q1260 rogid:AG+FZo/KK2xdMFSEIgTbgZ2AVJc9606 intact-crc:028D7B12879783BE|rigid:LQghCovuyvuFy+AxBONG529rx54 false sufficient binding region:239-616 125i radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography) uniprotkb:Q2TV77 uniprotkb:Q2TV77 intact:EBI-6405263 intact:EBI-6405263 psi-mi:q2tv77_finma(display_long)|uniprotkb:faf(gene name)|psi-mi:faf(display_short) psi-mi:q2tv77_finma(display_long)|uniprotkb:faf(gene name)|psi-mi:faf(display_short) psi-mi:"MI:0047"(far western blotting) Frick et al. (2008) pubmed:18808384|imex:IM-18235 taxid:1260(pepma)|taxid:1260(Peptostreptococcus magnus) taxid:1260(pepma)|taxid:1260(Peptostreptococcus magnus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6404529|mpidb:MPIDB-INT-615|imex:IM-18235-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033764|interpro:IPR019931 go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033764|interpro:IPR019931 - - - figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:x26dbTkLnV/GAmJv6yxOVNEBE6Q1260 rogid:x26dbTkLnV/GAmJv6yxOVNEBE6Q1260 intact-crc:43507B1FB7A3326E|rigid:JdeZyBn1bECO/TTBaadvIrbsOwQ false - 125i radiolabel:?-? - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)