#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10408	uniprotkb:P0AGA2	intact:EBI-543213|uniprotkb:P75642|ensemblbacteria:AAC73209|ensemblbacteria:BAB96666	intact:EBI-761422|uniprotkb:P03844|uniprotkb:Q2M6W5|ensemblbacteria:AAC76325|ensemblbacteria:BAE77991	psi-mi:seca_ecoli(display_long)|uniprotkb:secA(gene name)|psi-mi:secA(display_short)|uniprotkb:azi(gene name synonym)|uniprotkb:pea(gene name synonym)|uniprotkb:prlD(gene name synonym)|uniprotkb:b0098(locus name)|uniprotkb:JW0096(locus name)	psi-mi:secy_ecoli(display_long)|uniprotkb:secY(gene name)|psi-mi:secY(display_short)|uniprotkb:prlA(gene name synonym)|uniprotkb:b3300(locus name)|uniprotkb:JW3262(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Karamanou et al. (2008)	pubmed:18761620|imex:IM-18230	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6504166|imex:IM-18230-4|mpidb:MPIDB-INT-610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_414640.1|refseq:WP_000905789.1|ensemblbacteria:AAC73209(transcript)|ensemblbacteria:b0098(gene)|ensemblbacteria:BAB96666(gene)|ensemblbacteria:BAB96666(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008564"(protein-exporting ATPase activity)|go:"GO:0015031"(protein transport)|go:"GO:0015462"(ABC-type protein transporter activity)|go:"GO:0017038"(protein import)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0070678"(preprotein binding)|interpro:IPR000185(SecA protein)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004027(SEC-C motif)|interpro:IPR011115(SecA DEAD-like)|interpro:IPR011116(SecA Wing and Scaffold)|interpro:IPR011130(SecA preprotein cross-linking region)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014018(SecA motor DEAD)|interpro:IPR020937|interpro:IPR027417|interpro:IPR036266|interpro:IPR036670|interpro:IPR044722|rcsb pdb:1TM6|rcsb pdb:2FSF|rcsb pdb:2FSG|rcsb pdb:2FSH|rcsb pdb:2FSI|rcsb pdb:2VDA|rcsb pdb:3BXZ|rcsb pdb:6GOX|dip:DIP-10840N	refseq:NP_417759.1|refseq:WP_001118861.1|dip:DIP-59302N|ensemblbacteria:AAC76325(transcript)|ensemblbacteria:b3300(gene)|ensemblbacteria:BAE77991(gene)|ensemblbacteria:BAE77991(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0065002"(intracellular protein transmembrane transport)|interpro:IPR002208(SecY protein)|interpro:IPR023201|interpro:IPR026593|interpro:IPR030659|rcsb pdb:2AKH|rcsb pdb:2AKI|rcsb pdb:3J45|rcsb pdb:3J46|rcsb pdb:4V6M|rcsb pdb:5ABB|rcsb pdb:5GAE|rcsb pdb:5MG3|rcsb pdb:5NCO|rcsb pdb:6R7L	-	-	-	figure legend:Fig. 1C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:yulYx4jc3iGczAjpx1NdEIupGKw83333	rogid:bkj4LXOWFcRf8+ZfdG8YNQc3Y7g83333	intact-crc:3E170688EDF586C7|rigid:0t1ouEBKsPTb4dSfT5nqSCPSjgs	false	-	sufficient binding region:247-259|sufficient binding region:13-25|sufficient binding region:108-121	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10408	uniprotkb:P0AG99	intact:EBI-543213|uniprotkb:P75642|ensemblbacteria:AAC73209|ensemblbacteria:BAB96666	intact:EBI-6404248|ensemblbacteria:AAC76207|ensemblbacteria:BAE77219|uniprotkb:Q2M937|uniprotkb:P33582	psi-mi:seca_ecoli(display_long)|uniprotkb:secA(gene name)|psi-mi:secA(display_short)|uniprotkb:azi(gene name synonym)|uniprotkb:pea(gene name synonym)|uniprotkb:prlD(gene name synonym)|uniprotkb:b0098(locus name)|uniprotkb:JW0096(locus name)	psi-mi:secg_ecoli(display_long)|uniprotkb:P12(gene name synonym)|uniprotkb:Preprotein translocase band 1 subunit(gene name synonym)|uniprotkb:JW3142(locus name)|uniprotkb:b3175(locus name)|uniprotkb:secG(gene name)|psi-mi:secG(display_short)	psi-mi:"MI:0081"(peptide array)	Karamanou et al. (2008)	pubmed:18761620|imex:IM-18230	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6404245|mpidb:MPIDB-INT-611|imex:IM-18230-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_414640.1|refseq:WP_000905789.1|ensemblbacteria:AAC73209(transcript)|ensemblbacteria:b0098(gene)|ensemblbacteria:BAB96666(gene)|ensemblbacteria:BAB96666(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008564"(protein-exporting ATPase activity)|go:"GO:0015031"(protein transport)|go:"GO:0015462"(ABC-type protein transporter activity)|go:"GO:0017038"(protein import)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0070678"(preprotein binding)|interpro:IPR000185(SecA protein)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004027(SEC-C motif)|interpro:IPR011115(SecA DEAD-like)|interpro:IPR011116(SecA Wing and Scaffold)|interpro:IPR011130(SecA preprotein cross-linking region)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014018(SecA motor DEAD)|interpro:IPR020937|interpro:IPR027417|interpro:IPR036266|interpro:IPR036670|interpro:IPR044722|rcsb pdb:1TM6|rcsb pdb:2FSF|rcsb pdb:2FSG|rcsb pdb:2FSH|rcsb pdb:2FSI|rcsb pdb:2VDA|rcsb pdb:3BXZ|rcsb pdb:6GOX|dip:DIP-10840N	ensemblbacteria:AAC76207(transcript)|ensemblbacteria:b3175(gene)|ensemblbacteria:BAE77219(gene)|ensemblbacteria:BAE77219(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0065002"(intracellular protein transmembrane transport)|interpro:IPR004692(Preprotein translocase SecG subunit)|rcsb pdb:2AKH|rcsb pdb:2AKI|rcsb pdb:3J45|rcsb pdb:3J46|rcsb pdb:5MG3|rcsb pdb:5NCO|refseq:WP_001295556.1|mint:P0AG99|refseq:NP_417642.1|dip:DIP-47480N	-	-	-	figure legend:Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:yulYx4jc3iGczAjpx1NdEIupGKw83333	rogid:7v7uXXyGEOasIRWvJ3w7ABBhLWk83333	intact-crc:6077A64D9A1377D3|rigid:cO2kZV+KYIc3yRjXCw+P/SVm7ss	false	-	tag:c-c|sufficient binding region:70-82	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0AGA2	uniprotkb:P10408	intact:EBI-761422|uniprotkb:P03844|uniprotkb:Q2M6W5|ensemblbacteria:AAC76325|ensemblbacteria:BAE77991	intact:EBI-543213|uniprotkb:P75642|ensemblbacteria:AAC73209|ensemblbacteria:BAB96666	psi-mi:secy_ecoli(display_long)|uniprotkb:secY(gene name)|psi-mi:secY(display_short)|uniprotkb:prlA(gene name synonym)|uniprotkb:b3300(locus name)|uniprotkb:JW3262(locus name)	psi-mi:seca_ecoli(display_long)|uniprotkb:secA(gene name)|psi-mi:secA(display_short)|uniprotkb:azi(gene name synonym)|uniprotkb:pea(gene name synonym)|uniprotkb:prlD(gene name synonym)|uniprotkb:b0098(locus name)|uniprotkb:JW0096(locus name)	psi-mi:"MI:0081"(peptide array)	Karamanou et al. (2008)	pubmed:18761620|imex:IM-18230	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6404259|mpidb:MPIDB-INT-610|imex:IM-18230-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417759.1|refseq:WP_001118861.1|dip:DIP-59302N|ensemblbacteria:AAC76325(transcript)|ensemblbacteria:b3300(gene)|ensemblbacteria:BAE77991(gene)|ensemblbacteria:BAE77991(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0065002"(intracellular protein transmembrane transport)|interpro:IPR002208(SecY protein)|interpro:IPR023201|interpro:IPR026593|interpro:IPR030659|rcsb pdb:2AKH|rcsb pdb:2AKI|rcsb pdb:3J45|rcsb pdb:3J46|rcsb pdb:4V6M|rcsb pdb:5ABB|rcsb pdb:5GAE|rcsb pdb:5MG3|rcsb pdb:5NCO|rcsb pdb:6R7L	refseq:NP_414640.1|refseq:WP_000905789.1|ensemblbacteria:AAC73209(transcript)|ensemblbacteria:b0098(gene)|ensemblbacteria:BAB96666(gene)|ensemblbacteria:BAB96666(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008564"(protein-exporting ATPase activity)|go:"GO:0015031"(protein transport)|go:"GO:0015462"(ABC-type protein transporter activity)|go:"GO:0017038"(protein import)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0070678"(preprotein binding)|interpro:IPR000185(SecA protein)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004027(SEC-C motif)|interpro:IPR011115(SecA DEAD-like)|interpro:IPR011116(SecA Wing and Scaffold)|interpro:IPR011130(SecA preprotein cross-linking region)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014018(SecA motor DEAD)|interpro:IPR020937|interpro:IPR027417|interpro:IPR036266|interpro:IPR036670|interpro:IPR044722|rcsb pdb:1TM6|rcsb pdb:2FSF|rcsb pdb:2FSG|rcsb pdb:2FSH|rcsb pdb:2FSI|rcsb pdb:2VDA|rcsb pdb:3BXZ|rcsb pdb:6GOX|dip:DIP-10840N	-	-	-	figure legend:Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:bkj4LXOWFcRf8+ZfdG8YNQc3Y7g83333	rogid:yulYx4jc3iGczAjpx1NdEIupGKw83333	intact-crc:3D6112DC0EDBAF4F|rigid:0t1ouEBKsPTb4dSfT5nqSCPSjgs	false	sufficient binding region:361-373|sufficient binding region:247-259|sufficient binding region:346-358|sufficient binding region:13-22|sufficient binding region:428-442|sufficient binding region:230-241|tag:c-c|sufficient binding region:108-121	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10408	uniprotkb:P0AG96	intact:EBI-543213|uniprotkb:P75642|ensemblbacteria:AAC73209|ensemblbacteria:BAB96666	intact:EBI-6404267|ensemblbacteria:AAC76955|ensemblbacteria:BAE77339|uniprotkb:Q2M8R7|uniprotkb:P16920	psi-mi:seca_ecoli(display_long)|uniprotkb:secA(gene name)|psi-mi:secA(display_short)|uniprotkb:azi(gene name synonym)|uniprotkb:pea(gene name synonym)|uniprotkb:prlD(gene name synonym)|uniprotkb:b0098(locus name)|uniprotkb:JW0096(locus name)	psi-mi:sece_ecoli(display_long)|uniprotkb:JW3944(locus name)|uniprotkb:b3981(locus name)|uniprotkb:secE(gene name)|psi-mi:secE(display_short)|uniprotkb:prlG(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Karamanou et al. (2008)	pubmed:18761620|imex:IM-18230	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0903"(mpidb)	intact:EBI-6404264|mpidb:MPIDB-INT-609|imex:IM-18230-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_414640.1|refseq:WP_000905789.1|ensemblbacteria:AAC73209(transcript)|ensemblbacteria:b0098(gene)|ensemblbacteria:BAB96666(gene)|ensemblbacteria:BAB96666(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008564"(protein-exporting ATPase activity)|go:"GO:0015031"(protein transport)|go:"GO:0015462"(ABC-type protein transporter activity)|go:"GO:0017038"(protein import)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043952"(protein transport by the Sec complex)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0070678"(preprotein binding)|interpro:IPR000185(SecA protein)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004027(SEC-C motif)|interpro:IPR011115(SecA DEAD-like)|interpro:IPR011116(SecA Wing and Scaffold)|interpro:IPR011130(SecA preprotein cross-linking region)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014018(SecA motor DEAD)|interpro:IPR020937|interpro:IPR027417|interpro:IPR036266|interpro:IPR036670|interpro:IPR044722|rcsb pdb:1TM6|rcsb pdb:2FSF|rcsb pdb:2FSG|rcsb pdb:2FSH|rcsb pdb:2FSI|rcsb pdb:2VDA|rcsb pdb:3BXZ|rcsb pdb:6GOX|dip:DIP-10840N	ensemblbacteria:AAC76955(transcript)|ensemblbacteria:b3981(gene)|ensemblbacteria:BAE77339(gene)|ensemblbacteria:BAE77339(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0065002"(intracellular protein transmembrane transport)|interpro:IPR001901(Protein secE/sec61-gamma protein)|interpro:IPR005807(SecE subunit of protein translocation complex)|interpro:IPR038379|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|rcsb pdb:2AKH|rcsb pdb:2AKI|rcsb pdb:3J45|rcsb pdb:3J46|rcsb pdb:4V6M|rcsb pdb:5GAE|rcsb pdb:5MG3|rcsb pdb:5NCO|go:"GO:0006886"(intracellular protein transport)|rcsb pdb:6R7L|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0015450"(protein-transporting ATPase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031522"(cell envelope Sec protein transport complex)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0043952"(protein transport by the Sec complex)|refseq:WP_001275702.1|refseq:NP_418408.1|dip:DIP-59303N	-	-	-	figure legend:Supp. Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/30	2014/10/16	rogid:yulYx4jc3iGczAjpx1NdEIupGKw83333	rogid:6fuhtMf4WGR/D92xi4zIqFuzHgs83333	intact-crc:FCAF729CF5DB93F6|rigid:yMpwCEPyH9qclCONPF9GP60o2MI	false	-	tag:c-c|sufficient binding region:31-43|sufficient binding region:61-73	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)