#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q7DB77 uniprotkb:Q7DB79 intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396 intact:EBI-6403821|ensemblbacteria:BAB37980|ensemblbacteria:QCH80451|uniprotkb:Q7A9Q3|uniprotkb:A0A0H3JHT2|uniprotkb:A0A6M0JNM5 psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name) psi-mi:q7db79_eco57(display_long)|uniprotkb:E5F08_27385(orf name)|uniprotkb:sepL(gene name)|psi-mi:sepL(display_short)|uniprotkb:ECs_4557(orf name) psi-mi:"MI:0047"(far western blotting) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6480808|imex:IM-18219-3|mpidb:MPIDB-INT-624 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003 ensemblbacteria:BAB37980(transcript)|ensemblbacteria:CAM50_0000430(gene)|ensemblbacteria:ECs_4557(gene)|ensemblbacteria:QCH80451(transcript)|go:"GO:0019867"(outer membrane)|go:"GO:0046903"(secretion)|interpro:IPR038347|refseq:WP_001273445.1|refseq:NP_312584.1|interpro:IPR010812(Hypersensitivity response secretion HrpJ)|interpro:IPR013351(Type III secretion system effector delivery regulator TyeA) - - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:w091zQ2yloHiTr07621yQtr7n0w83334 rogid:hXMyrxfcah2t6q3KpFNM7IuQY8Q83334 intact-crc:85E124356EF4128B|rigid:eOAcUERRisJfccSpfJF6yWVjhFE false his tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7DB77 uniprotkb:P58233 intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396 intact:EBI-6403832|ensemblbacteria:AAG58824|ensemblbacteria:BAB37983 psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name) psi-mi:cest_eco57(display_long)|uniprotkb:L0026(orf name)|uniprotkb:ECs4560(locus name)|uniprotkb:Z5111(locus name)|uniprotkb:cesT(gene name)|psi-mi:cesT(display_short) psi-mi:"MI:0047"(far western blotting) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6403838|mpidb:MPIDB-INT-624|imex:IM-18219-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003 ensemblbacteria:AAG58824(transcript)|ensemblbacteria:BAB37983(transcript)|ensemblbacteria:ECs_4560(gene)|ensemblbacteria:Z5111(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0030254"(protein secretion by the type III secretion system)|refseq:WP_000098793.1|interpro:IPR010261(Tir chaperone)|rcsb pdb:1K3E|refseq:NP_312587.1 - - - figure legend:Fig 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:w091zQ2yloHiTr07621yQtr7n0w83334 rogid:UIHuXR/53T3h1b3IJjxsJYFakHM83334 intact-crc:D0E2215FA3890DED|rigid:eeMA9KPU3jO7o5brlSZHOf4gEZw false his tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7DB79 uniprotkb:Q7DB65 intact:EBI-6403821|ensemblbacteria:BAB37980|ensemblbacteria:QCH80451|uniprotkb:Q7A9Q3|uniprotkb:A0A0H3JHT2|uniprotkb:A0A6M0JNM5 intact:EBI-6403815|ensemblbacteria:BAB37997|ensemblbacteria:QCH80434|uniprotkb:Q7A9N8|uniprotkb:A0A0H3JIS5|uniprotkb:A0A6M0JLB3 psi-mi:q7db79_eco57(display_long)|uniprotkb:E5F08_27385(orf name)|uniprotkb:sepL(gene name)|psi-mi:sepL(display_short)|uniprotkb:ECs_4557(orf name) psi-mi:q7db65_eco57(display_long)|uniprotkb:E5F08_27470(orf name)|uniprotkb:sepD(gene name)|psi-mi:sepD(display_short)|uniprotkb:ECs_4574(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6403827|mpidb:MPIDB-INT-625|imex:IM-18219-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:BAB37980(transcript)|ensemblbacteria:CAM50_0000430(gene)|ensemblbacteria:ECs_4557(gene)|ensemblbacteria:QCH80451(transcript)|go:"GO:0019867"(outer membrane)|go:"GO:0046903"(secretion)|interpro:IPR038347|refseq:WP_001273445.1|refseq:NP_312584.1|interpro:IPR010812(Hypersensitivity response secretion HrpJ)|interpro:IPR013351(Type III secretion system effector delivery regulator TyeA) refseq:WP_001063681.1|ensemblbacteria:BAB37997(transcript)|ensemblbacteria:CAM50_0000345(gene)|ensemblbacteria:ECs_4574(gene)|ensemblbacteria:QCH80434(transcript)|refseq:NP_312601.1 - - - figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:hXMyrxfcah2t6q3KpFNM7IuQY8Q83334 rogid:qwqAIuuTCe7QBOgST2AFoP1paj883334 intact-crc:FFAF0584B689CEB9|rigid:8BhNuz88fvLvLnzt85yr+OwnKAU false necessary binding region:191-290|enhanced green fluorescent protein tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7DB77 uniprotkb:Q7DB79 intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396 intact:EBI-6403821|ensemblbacteria:BAB37980|ensemblbacteria:QCH80451|uniprotkb:Q7A9Q3|uniprotkb:A0A0H3JHT2|uniprotkb:A0A6M0JNM5 psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name) psi-mi:q7db79_eco57(display_long)|uniprotkb:E5F08_27385(orf name)|uniprotkb:sepL(gene name)|psi-mi:sepL(display_short)|uniprotkb:ECs_4557(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6480884|imex:IM-18219-6|mpidb:MPIDB-INT-624 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003 ensemblbacteria:BAB37980(transcript)|ensemblbacteria:CAM50_0000430(gene)|ensemblbacteria:ECs_4557(gene)|ensemblbacteria:QCH80451(transcript)|go:"GO:0019867"(outer membrane)|go:"GO:0046903"(secretion)|interpro:IPR038347|refseq:WP_001273445.1|refseq:NP_312584.1|interpro:IPR010812(Hypersensitivity response secretion HrpJ)|interpro:IPR013351(Type III secretion system effector delivery regulator TyeA) - - - figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:w091zQ2yloHiTr07621yQtr7n0w83334 rogid:hXMyrxfcah2t6q3KpFNM7IuQY8Q83334 intact-crc:0D9F1F643F3A2DFA|rigid:eOAcUERRisJfccSpfJF6yWVjhFE false his tag:?-?|sufficient binding region:200-382 glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7DB77 uniprotkb:Q7DB79 intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396 intact:EBI-6403821|ensemblbacteria:BAB37980|ensemblbacteria:QCH80451|uniprotkb:Q7A9Q3|uniprotkb:A0A0H3JHT2|uniprotkb:A0A6M0JNM5 psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name) psi-mi:q7db79_eco57(display_long)|uniprotkb:E5F08_27385(orf name)|uniprotkb:sepL(gene name)|psi-mi:sepL(display_short)|uniprotkb:ECs_4557(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6480862|imex:IM-18219-4|mpidb:MPIDB-INT-624 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003 ensemblbacteria:BAB37980(transcript)|ensemblbacteria:CAM50_0000430(gene)|ensemblbacteria:ECs_4557(gene)|ensemblbacteria:QCH80451(transcript)|go:"GO:0019867"(outer membrane)|go:"GO:0046903"(secretion)|interpro:IPR038347|refseq:WP_001273445.1|refseq:NP_312584.1|interpro:IPR010812(Hypersensitivity response secretion HrpJ)|interpro:IPR013351(Type III secretion system effector delivery regulator TyeA) - - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:w091zQ2yloHiTr07621yQtr7n0w83334 rogid:hXMyrxfcah2t6q3KpFNM7IuQY8Q83334 intact-crc:F1CFB06C4D153837|rigid:eOAcUERRisJfccSpfJF6yWVjhFE false his tag:?-? necessary binding region:341-351|enhanced green fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7DB77 uniprotkb:Q7DB79 intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396 intact:EBI-6403821|ensemblbacteria:BAB37980|ensemblbacteria:QCH80451|uniprotkb:Q7A9Q3|uniprotkb:A0A0H3JHT2|uniprotkb:A0A6M0JNM5 psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name) psi-mi:q7db79_eco57(display_long)|uniprotkb:E5F08_27385(orf name)|uniprotkb:sepL(gene name)|psi-mi:sepL(display_short)|uniprotkb:ECs_4557(orf name) psi-mi:"MI:0096"(pull down) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6480873|imex:IM-18219-5|mpidb:MPIDB-INT-624 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003 ensemblbacteria:BAB37980(transcript)|ensemblbacteria:CAM50_0000430(gene)|ensemblbacteria:ECs_4557(gene)|ensemblbacteria:QCH80451(transcript)|go:"GO:0019867"(outer membrane)|go:"GO:0046903"(secretion)|interpro:IPR038347|refseq:WP_001273445.1|refseq:NP_312584.1|interpro:IPR010812(Hypersensitivity response secretion HrpJ)|interpro:IPR013351(Type III secretion system effector delivery regulator TyeA) - - - figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:w091zQ2yloHiTr07621yQtr7n0w83334 rogid:hXMyrxfcah2t6q3KpFNM7IuQY8Q83334 intact-crc:B8F82AC311B332B9|rigid:eOAcUERRisJfccSpfJF6yWVjhFE false his tag:?-? sufficient binding region:303-351|glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q7DB77 uniprotkb:P58233 intact:EBI-6480811|ensemblbacteria:AAG58825|ensemblbacteria:BAB37984|uniprotkb:Q7A9Q1|uniprotkb:Q9R396 intact:EBI-6403832|ensemblbacteria:AAG58824|ensemblbacteria:BAB37983 psi-mi:tir_eco57(display_long)|uniprotkb:tir(gene name)|psi-mi:tir(display_short)|uniprotkb:espE(gene name synonym)|uniprotkb:Secreted effector protein Tir(gene name synonym)|uniprotkb:Z5112(locus name)|uniprotkb:ECs4561(locus name) psi-mi:cest_eco57(display_long)|uniprotkb:L0026(orf name)|uniprotkb:ECs4560(locus name)|uniprotkb:Z5111(locus name)|uniprotkb:cesT(gene name)|psi-mi:cesT(display_short) psi-mi:"MI:0096"(pull down) Wang et al. (2008) pubmed:18673458|imex:IM-18219 taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6480897|imex:IM-18219-7|mpidb:MPIDB-INT-624 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q7DB77|ensemblbacteria:AAG58825(transcript)|ensemblbacteria:BAB37984(transcript)|ensemblbacteria:ECs_4561(gene)|ensemblbacteria:Z5112(gene)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|rcsb pdb:2ZQK|rcsb pdb:2ZWK|refseq:WP_001301454.1|refseq:NP_312588.1|interpro:IPR022638|interpro:IPR022639|interpro:IPR003536(Translocated intimin receptor)|interpro:IPR022633|interpro:IPR037003 ensemblbacteria:AAG58824(transcript)|ensemblbacteria:BAB37983(transcript)|ensemblbacteria:ECs_4560(gene)|ensemblbacteria:Z5111(gene)|go:"GO:0005737"(cytoplasm)|go:"GO:0030254"(protein secretion by the type III secretion system)|refseq:WP_000098793.1|interpro:IPR010261(Tir chaperone)|rcsb pdb:1K3E|refseq:NP_312587.1 - - - figure legend:Fig 5B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:w091zQ2yloHiTr07621yQtr7n0w83334 rogid:UIHuXR/53T3h1b3IJjxsJYFakHM83334 intact-crc:D0E22288C29C6F2F|rigid:eeMA9KPU3jO7o5brlSZHOf4gEZw false sufficient binding region:383-558|sufficient binding region:100-200|his tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)