#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q13491 uniprotkb:P31645 intact:EBI-4397339|uniprotkb:O76077|uniprotkb:Q86X43|uniprotkb:Q8N956|ensembl:ENSP00000349420 intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537 psi-mi:gpm6b_human(display_long)|uniprotkb:GPM6B(gene name)|psi-mi:GPM6B(display_short)|uniprotkb:M6B(gene name synonym) psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Fjorback et al. (2009) pubmed:18581270|imex:IM-17315 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6116134|imex:IM-17315-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001994.1|refseq:NP_001001995.1|refseq:NP_001001996.1|refseq:NP_005269.1|ensembl:ENSG00000046653(gene)|ensembl:ENST00000356942(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045121"(membrane raft)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|go:"GO:0015031"(protein transport) refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615 - - - figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2012/05/03 2014/10/16 rogid:eNSbjdvVOvvLIowS7p8EZ9TIj0Q9606 rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606 intact-crc:F040D51F0302FAFE|rigid:+RMtXrcYWRnt3YlWOJOdg1WpEX8 false - sufficient binding region:1-108 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P35803 uniprotkb:P31645 intact:EBI-6116313|uniprotkb:A2AEG4|uniprotkb:Q8R3J6|uniprotkb:Q99L14|uniprotkb:Q9D4F5|uniprotkb:Q9JHG9|uniprotkb:Q9JHI1|uniprotkb:Q9JHK2|uniprotkb:Q9JI62|uniprotkb:Q9JI63|uniprotkb:Q9JI64|uniprotkb:Q9JI65 intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537 psi-mi:gpm6b_mouse(display_long)|uniprotkb:Gpm6b(gene name)|psi-mi:Gpm6b(display_short)|uniprotkb:M6b(gene name synonym) psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym) psi-mi:"MI:0096"(pull down) Fjorback et al. (2009) pubmed:18581270|imex:IM-17315 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6116148|imex:IM-17315-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P35803|refseq:NP_001171426.1|refseq:NP_001171427.1|refseq:NP_001171428.1|refseq:NP_001171429.1|refseq:NP_001171430.1|refseq:NP_001171431.1|refseq:NP_001171432.1|refseq:NP_001171433.1|refseq:NP_075611.1|interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|go:"GO:0001503"(ossification)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045121"(membrane raft)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface) refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615 - - - figure legend:1b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/05/03 2014/10/16 rogid:Q/XMQgIGFQtvHMkzuSlsBd5Oj8I10090 rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606 intact-crc:11F02E50C609FC59|rigid:IzbB1rD2XlnuV7kNcVN0qOY2WBs false myc tag:?-? glutathione s tranferase tag:?-?|necessary binding region:1-180 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P31652 uniprotkb:Q9JJK1 intact:EBI-6116206|uniprotkb:P23976|ensembl:ENSRNOP00000004717 intact:EBI-6116248 psi-mi:sc6a4_rat(display_long)|uniprotkb:Slc6a4(gene name)|psi-mi:Slc6a4(display_short)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym) psi-mi:gpm6b_rat(display_long)|uniprotkb:Gpm6b(gene name)|psi-mi:Gpm6b(display_short)|uniprotkb:rhombex-29(gene name synonym)|uniprotkb:M6b(gene name synonym)|uniprotkb:Rhombencephalic expression protein-29 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fjorback et al. (2009) pubmed:18581270|imex:IM-17315 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6116246|imex:IM-17315-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_008766172.1|rgd:3714|refseq:NP_037166.2|refseq:XP_017452530.1|refseq:XP_017452531.1|refseq:XP_017452532.1|ensembl:ENSRNOG00000003476(gene)|ensembl:ENSRNOT00000004717(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006837"(serotonin transport)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0098810"(neurotransmitter reuptake)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|reactome:R-RNO-380615 interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|rgd:620580|refseq:NP_620201.1|go:"GO:0001503"(ossification)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045121"(membrane raft)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface) - - - figure legend:1c|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2012/05/03 2014/10/16 rogid:YDmEK+2iss4sAqK0fh3wa2BC3EY10116 rogid:qo+QycPLlHRtDa6FV2vYS7D29tU10116 intact-crc:266272FD9E2FAC91|rigid:/6uYpbDnk+jVMMmiGeJD2VPNhsQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31652 uniprotkb:Q9JJK1 intact:EBI-6116206|uniprotkb:P23976|ensembl:ENSRNOP00000004717 intact:EBI-6116248 psi-mi:sc6a4_rat(display_long)|uniprotkb:Slc6a4(gene name)|psi-mi:Slc6a4(display_short)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym) psi-mi:gpm6b_rat(display_long)|uniprotkb:Gpm6b(gene name)|psi-mi:Gpm6b(display_short)|uniprotkb:rhombex-29(gene name synonym)|uniprotkb:M6b(gene name synonym)|uniprotkb:Rhombencephalic expression protein-29 kDa(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Fjorback et al. (2009) pubmed:18581270|imex:IM-17315 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6116285|imex:IM-17315-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_008766172.1|rgd:3714|refseq:NP_037166.2|refseq:XP_017452530.1|refseq:XP_017452531.1|refseq:XP_017452532.1|ensembl:ENSRNOG00000003476(gene)|ensembl:ENSRNOT00000004717(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0006837"(serotonin transport)|go:"GO:0007420"(brain development)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0098810"(neurotransmitter reuptake)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|reactome:R-RNO-380615 interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|rgd:620580|refseq:NP_620201.1|go:"GO:0001503"(ossification)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045121"(membrane raft)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface) go:"GO:0005886"(plasma membrane) - - figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-rn46a)|taxid:10116(Rattus norvegicus RN46A cell line) - 2012/05/03 2014/10/16 rogid:YDmEK+2iss4sAqK0fh3wa2BC3EY10116 rogid:qo+QycPLlHRtDa6FV2vYS7D29tU10116 intact-crc:8E30A69BF8BFA994|rigid:/6uYpbDnk+jVMMmiGeJD2VPNhsQ false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P31645 uniprotkb:P35803 intact:EBI-6116107|uniprotkb:Q5EE02|ensembl:ENSP00000261707|ensembl:ENSP00000385822|ensembl:ENSP00000498537 intact:EBI-6116313|uniprotkb:A2AEG4|uniprotkb:Q8R3J6|uniprotkb:Q99L14|uniprotkb:Q9D4F5|uniprotkb:Q9JHG9|uniprotkb:Q9JHI1|uniprotkb:Q9JHK2|uniprotkb:Q9JI62|uniprotkb:Q9JI63|uniprotkb:Q9JI64|uniprotkb:Q9JI65 psi-mi:sc6a4_human(display_long)|uniprotkb:SLC6A4(gene name)|psi-mi:SLC6A4(display_short)|uniprotkb:HTT(gene name synonym)|uniprotkb:SERT(gene name synonym)|uniprotkb:5HT transporter(gene name synonym)|uniprotkb:Solute carrier family 6 member 4(gene name synonym) psi-mi:gpm6b_mouse(display_long)|uniprotkb:Gpm6b(gene name)|psi-mi:Gpm6b(display_short)|uniprotkb:M6b(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Fjorback et al. (2009) pubmed:18581270|imex:IM-17315 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6116356|imex:IM-17315-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001036.1|ensembl:ENSG00000108576(gene)|ensembl:ENST00000261707(transcript)|ensembl:ENST00000401766(transcript)|ensembl:ENST00000650711(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005335"("serotonin:sodium symporter activity")|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008504"(monoamine transmembrane transporter activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012505"(endomembrane system)|go:"GO:0014064"(positive regulation of serotonin secretion)|go:"GO:0015844"(monoamine transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019811"(cocaine binding)|go:"GO:0021941"(negative regulation of cerebellar granule cell precursor proliferation)|go:"GO:0032227"(negative regulation of synaptic transmission, dopaminergic)|go:"GO:0032355"(response to estradiol)|go:"GO:0035176"(social behavior)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042493"|go:"GO:0042713"(sperm ejaculation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051378"(serotonin binding)|go:"GO:0051610"(serotonin uptake)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071321"(cellular response to cGMP)|go:"GO:0090067"(regulation of thalamus size)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099154"(serotonergic synapse)|interpro:IPR000175("Sodium:neurotransmitter symporter")|interpro:IPR013086("Sodium:neurotransmitter symporter, serotonin, N-terminal")|interpro:IPR037272|rcsb pdb:5I6X|rcsb pdb:5I6Z|rcsb pdb:5I71|rcsb pdb:5I73|rcsb pdb:5I74|rcsb pdb:5I75|rcsb pdb:6AWN|rcsb pdb:6AWO|rcsb pdb:6AWP|rcsb pdb:6AWQ|rcsb pdb:6DZV|rcsb pdb:6DZW|rcsb pdb:6DZY|rcsb pdb:6DZZ|rcsb pdb:6VRH|rcsb pdb:6VRK|rcsb pdb:6VRL|rcsb pdb:6W2B|rcsb pdb:6W2C|reactome:R-HSA-380615 mint:P35803|refseq:NP_001171426.1|refseq:NP_001171427.1|refseq:NP_001171428.1|refseq:NP_001171429.1|refseq:NP_001171430.1|refseq:NP_001171431.1|refseq:NP_001171432.1|refseq:NP_001171433.1|refseq:NP_075611.1|interpro:IPR001614(Myelin proteolipid protein PLP)|interpro:IPR018237|go:"GO:0001503"(ossification)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0045121"(membrane raft)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface) go:"GO:0045121"(membrane raft) - - figure legend:6a|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-msr-293)|taxid:9606(Homo sapiens) - 2012/05/03 2014/10/16 rogid:mZYK0YEOl23+K9N0+v10I6r/Y4o9606 rogid:Q/XMQgIGFQtvHMkzuSlsBd5Oj8I10090 intact-crc:A736F84A4CF7B8F5|rigid:IzbB1rD2XlnuV7kNcVN0qOY2WBs false - myc tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)