#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A5H447 uniprotkb:Q91898 intact:EBI-5651620 intact:EBI-5651634|uniprotkb:Q91899 psi-mi:zyx_xenla(display_long)|uniprotkb:zyx(gene name)|psi-mi:zyx(display_short) psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5650819|imex:IM-16937-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001092151.1 go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) - - - figure legend:"Fig. 3 (Lanes 1,2,8,9,10 and 11)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-embryo)|taxid:8355(Xenopus laevis embryo) - 2012/02/27 2014/10/16 rogid:wL4DtMYdqbhmM8mBSAxcHEqjaEk8355 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 intact-crc:0DB7101112A94D03|rigid:dhSYki5iF9LFIRuhNY3LQW47vxM false flag tag:n-n|sufficient binding region:373-663 myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A5H447 uniprotkb:Q91898 intact:EBI-5651620 intact:EBI-5651634|uniprotkb:Q91899 psi-mi:zyx_xenla(display_long)|uniprotkb:zyx(gene name)|psi-mi:zyx(display_short) psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5651798|imex:IM-16937-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001092151.1 go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) - - - figure legend:"Fig. 3 (Lanes 3,4) and 5C."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:8355(xenla-embryo)|taxid:8355(Xenopus laevis embryo) - 2012/02/27 2014/10/16 rogid:wL4DtMYdqbhmM8mBSAxcHEqjaEk8355 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 intact-crc:6632186B5B416430|rigid:dhSYki5iF9LFIRuhNY3LQW47vxM false sufficient binding region:373-663|flag tag:n-n myc tag:n-n|necessary binding region:1-77 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q91898 uniprotkb:A5H447 intact:EBI-5651634|uniprotkb:Q91899 intact:EBI-5651620 psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:zyx_xenla(display_long)|uniprotkb:zyx(gene name)|psi-mi:zyx(display_short) psi-mi:"MI:0018"(two hybrid) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5651689|imex:IM-16937-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001092151.1 - - - figure legend:Fig. 4A and 5A.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/27 2014/10/16 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 rogid:wL4DtMYdqbhmM8mBSAxcHEqjaEk8355 intact-crc:04B4DD2785B07EFE|rigid:dhSYki5iF9LFIRuhNY3LQW47vxM false necessary binding region:1-77 necessary binding region:530-590 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91898 uniprotkb:A5H447 intact:EBI-5651634|uniprotkb:Q91899 intact:EBI-5651620 psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:zyx_xenla(display_long)|uniprotkb:zyx(gene name)|psi-mi:zyx(display_short) psi-mi:"MI:0096"(pull down) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5651723|imex:IM-16937-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001092151.1 - - - figure legend:Fig. 4B and 5B.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/27 2014/10/16 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 rogid:wL4DtMYdqbhmM8mBSAxcHEqjaEk8355 intact-crc:ACED6C208DFDBFB8|rigid:dhSYki5iF9LFIRuhNY3LQW47vxM false myc tag:n-n necessary binding region:530-590|glutathione s tranferase tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:A5H447 uniprotkb:Q91898 intact:EBI-5651620 intact:EBI-5651634|uniprotkb:Q91899 psi-mi:zyx_xenla(display_long)|uniprotkb:zyx(gene name)|psi-mi:zyx(display_short) psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5668356|imex:IM-16937-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001725"(stress fiber)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007155"(cell adhesion)|go:"GO:0008134"(transcription factor binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001781(Zinc finger, LIM-type)|refseq:NP_001092151.1 go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/27 2014/10/16 rogid:wL4DtMYdqbhmM8mBSAxcHEqjaEk8355 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 intact-crc:26E582B6B630CF62|rigid:dhSYki5iF9LFIRuhNY3LQW47vxM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q91898 uniprotkb:Q9DGG0 intact:EBI-5651634|uniprotkb:Q91899 intact:EBI-5669741 psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:q9dgg0_xenla(display_long)|uniprotkb:xirg(gene name)|psi-mi:xirg(display_short) psi-mi:"MI:0018"(two hybrid) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5668360|imex:IM-16937-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) interpro:IPR005656(MmgE/PrpD)|refseq:NP_001081912.1|interpro:IPR036148|interpro:IPR042183|interpro:IPR042188|go:"GO:0016829"(lyase activity) - - - comment:The XIRG protein is not annotated in swissprot and thus has been referenced with a TrEMBL identifier.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/27 2014/10/16 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 rogid:Y2WH/yvv+m3ralRjNnmYLiqIOBw8355 intact-crc:27A66448D5B905C7|rigid:8eQ+lKgEATHcfCUCYFmQCD5HrHQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q6PAF6 uniprotkb:Q91898 intact:EBI-5680785 intact:EBI-5651634|uniprotkb:Q91899 psi-mi:an32a_xenla(display_long)|uniprotkb:anp32a(gene name)|psi-mi:anp32a(display_short) psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5680739|imex:IM-16937-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001611(Leucine-rich repeat)|refseq:NP_001083156.1|interpro:IPR032675|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm) go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/27 2014/10/16 rogid:tQeubpBN3UksB+IQe3ccQndbWs08355 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 intact-crc:93BBC0437C7AD5F8|rigid:kngHlZQ+xZ6T2MK1QkdqzFiF4vE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q7SYH0 uniprotkb:Q91898 intact:EBI-5683010 intact:EBI-5651634|uniprotkb:Q91899 psi-mi:q7syh0_xenla(display_long) psi-mi:hesxb_xenla(display_long)|uniprotkb:hesx1-b(gene name)|psi-mi:hesx1-b(display_short)|uniprotkb:anf-1(gene name synonym)|uniprotkb:anf1(gene name synonym)|uniprotkb:Homeobox protein ANF-1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Martynova et al. (2008) pubmed:18297730|imex:IM-16937 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-5682990|imex:IM-16937-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032335 go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|refseq:NP_001156042.1|interpro:IPR043402|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0030900"(forebrain development)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060061"(Spemann organizer formation) - - - comment:The Sam68 protein is not annotated in swissprot and is referenced only by a TrEMBL entry. This TrEMBL entry for Sam68 corresponds to a partial protein sequence and not the full length protein.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/02/27 2014/10/16 rogid:iejHVoPstq28b7kFs19HEZKZsHU8355 rogid:9dtQLa469ncImhj95zZGV29jwXk8355 intact-crc:540829394F34D02B|rigid:eXFgCJSrmWH5Xg2LCDmjcoReaHQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)