#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8WV22 uniprotkb:Q96SB8 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485754|imex:IM-17210-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:EB72BD3B8E942403|rigid:r3UnwVfXYO5j2l5WiKANLGIQOS0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96SB8 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485760|imex:IM-17210-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:B1DB417B8E9392A0|rigid:r3UnwVfXYO5j2l5WiKANLGIQOS0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SB8 uniprotkb:Q96MF7 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485770|imex:IM-17210-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 - - - figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 intact-crc:8E0DFF8CF11ED93F|rigid:iuAv4oJGBsZnU8bwGiolH6MhOAM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96SB8 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485784|imex:IM-17210-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:B035EC852D3F0AB1|rigid:D9aIt0SO2ay+9IAfqXZ/sRLcCBs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96MF7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485784|imex:IM-17210-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 - - - figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 intact-crc:B035EC852D3F0AB1|rigid:D9aIt0SO2ay+9IAfqXZ/sRLcCBs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96SB8 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485950|imex:IM-17210-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:38263B53681C2EDC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96MF7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485950|imex:IM-17210-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 intact-crc:38263B53681C2EDC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q9NXX6 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485950|imex:IM-17210-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 intact-crc:38263B53681C2EDC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96MG7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485950|imex:IM-17210-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 intact-crc:38263B53681C2EDC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q8IY18 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485950|imex:IM-17210-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 intact-crc:38263B53681C2EDC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SB8 uniprotkb:Q8IY18 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5528862|imex:IM-17210-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 intact-crc:84D0F9974770F8D8|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SB8 uniprotkb:Q9NXX6 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5528862|imex:IM-17210-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 intact-crc:84D0F9974770F8D8|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SB8 uniprotkb:Q96MG7 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5528862|imex:IM-17210-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 intact-crc:84D0F9974770F8D8|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SB8 uniprotkb:Q8WV22 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5528862|imex:IM-17210-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 intact-crc:84D0F9974770F8D8|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96SB8 uniprotkb:Q96MF7 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5528862|imex:IM-17210-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 go:"GO:0030915"(Smc5-Smc6 complex) - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 intact-crc:84D0F9974770F8D8|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NXX6 uniprotkb:Q8WV22 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485858|imex:IM-17210-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line) - 2012/02/10 2014/10/16 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 intact-crc:D721CDD17BD3ACD8|rigid:FMgxdXUa3fmZm6jWVxzeWcWE7Ds false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9NXX6 uniprotkb:Q96SB8 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485858|imex:IM-17210-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line) - 2012/02/10 2014/10/16 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:D721CDD17BD3ACD8|rigid:FMgxdXUa3fmZm6jWVxzeWcWE7Ds false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N140 uniprotkb:Q96SB8 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485873|imex:IM-17210-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line) - 2012/02/10 2014/10/16 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:7CDB74D231112165|rigid:0eTmblQL3KDkupFPbd6JwiqUuNc false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N140 uniprotkb:Q8WV22 intact:EBI-744483|ensembl:ENSP00000435619 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:eid3_human(display_long)|uniprotkb:EID-1-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:E1A-like inhibitor of differentiation 3(gene name synonym)|uniprotkb:EID3(gene name)|psi-mi:EID3(display_short)|uniprotkb:Non-structural maintenance of chromosomes element 4 homolog B(gene name synonym) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485873|imex:IM-17210-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008395.1|ensembl:ENSG00000255150(gene)|ensembl:ENST00000527879(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line) - 2012/02/10 2014/10/16 rogid:rYLyS1Sq3Fy4fFEktUv6hvwgsA49606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 intact-crc:7CDB74D231112165|rigid:0eTmblQL3KDkupFPbd6JwiqUuNc false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96MG7 uniprotkb:Q8WV22 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485883|imex:IM-17210-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 - - - figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line) - 2012/02/10 2014/10/16 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 intact-crc:EFFDD12C1626703B|rigid:pw8Hyd/HK/tVdyo2vXaNxAEdGio false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q96MG7 uniprotkb:Q96SB8 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485883|imex:IM-17210-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:2D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line) - 2012/02/10 2014/10/16 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:EFFDD12C1626703B|rigid:pw8Hyd/HK/tVdyo2vXaNxAEdGio false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96SB8 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485918|imex:IM-17210-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:F881D7DF22925A0E|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WV22 uniprotkb:Q9NXX6 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485918|imex:IM-17210-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 intact-crc:F881D7DF22925A0E|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WV22 uniprotkb:Q8IY18 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485918|imex:IM-17210-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 intact-crc:F881D7DF22925A0E|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WV22 uniprotkb:Q96MG7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485918|imex:IM-17210-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 intact-crc:F881D7DF22925A0E|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WV22 uniprotkb:Q96MF7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485918|imex:IM-17210-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 intact-crc:F881D7DF22925A0E|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SB8 uniprotkb:Q96MG7 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485932|imex:IM-17210-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 intact-crc:F20AA9B1792B4E67|rigid:8L2DvnF0xEQRY3PwWV4c6j7+s/A false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SB8 uniprotkb:Q8IY18 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485932|imex:IM-17210-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 intact-crc:F20AA9B1792B4E67|rigid:8L2DvnF0xEQRY3PwWV4c6j7+s/A false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SB8 uniprotkb:Q9NXX6 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485932|imex:IM-17210-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 - - - figure legend:Table I|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 intact-crc:F20AA9B1792B4E67|rigid:8L2DvnF0xEQRY3PwWV4c6j7+s/A false - - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WV22 uniprotkb:Q96MF7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557388|uniprotkb:Q8N549|ensembl:ENSP00000287437|ensembl:ENSP00000430668 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse2_human(display_long)|uniprotkb:NSMCE2(gene name)|psi-mi:NSMCE2(display_short)|uniprotkb:C8orf36(gene name synonym)|uniprotkb:MMS21(gene name synonym)|uniprotkb:Non-structural maintenance of chromosomes element 2 homolog(gene name synonym)|uniprotkb:MMS21 homolog(gene name synonym)|uniprotkb:E3 SUMO-protein transferase NSE2(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485983|imex:IM-17210-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:XP_011515276.1|refseq:XP_011515277.1|ensembl:ENSG00000156831(gene)|ensembl:ENST00000287437(transcript)|ensembl:ENST00000522563(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0090398"(cellular senescence)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026846|rcsb pdb:2YU4|reactome:R-HSA-3108214|refseq:NP_775956.1|refseq:XP_005250932.1|refseq:XP_005250933.1|refseq:XP_016868820.1 go:"GO:0005634"(nucleus) - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:AwMaEV2fH8rhBJhoTcvcV6glb7w9606 intact-crc:FD7F2F4FADB6F0DC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96MG7 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557356|uniprotkb:Q9H214|uniprotkb:Q8TEI6|uniprotkb:Q8IW16|ensembl:ENSP00000330694|ensembl:ENSP00000487893 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse3_human(display_long)|uniprotkb:HCA4(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein 4(gene name synonym)|uniprotkb:MAGE-G1 antigen(gene name synonym)|uniprotkb:MAGEG1(gene name synonym)|uniprotkb:Melanoma-associated antigen G1(gene name synonym)|uniprotkb:NDNL2(gene name synonym)|uniprotkb:Necdin-like protein 2(gene name synonym)|uniprotkb:NSMCE3(gene name)|psi-mi:NSMCE3(display_short) psi-mi:"MI:0071"(molecular sieving) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485983|imex:IM-17210-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000185115(gene)|ensembl:ENSG00000282130(gene)|ensembl:ENST00000332303(transcript)|ensembl:ENST00000631973(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0034644"(cellular response to UV)|go:"GO:0040008"(regulation of growth)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071478"(cellular response to radiation)|go:"GO:0072711"(cellular response to hydroxyurea)|interpro:IPR002190(MAGE protein)|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|rcsb pdb:5HVQ|rcsb pdb:5WY5|reactome:R-HSA-3108214|refseq:NP_619649.1 go:"GO:0005634"(nucleus) - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:dhvOBczXKSfuS3+NN8nivczrVYM9606 intact-crc:FD7F2F4FADB6F0DC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q9NXX6 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-2557393|uniprotkb:Q8WY66|uniprotkb:Q6P673|uniprotkb:Q9BS90|uniprotkb:Q5SQQ5|ensembl:ENSP00000358019 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:nse4a_human(display_long)|uniprotkb:NSMCE4A(gene name)|psi-mi:NSMCE4A(display_short)|uniprotkb:C10orf86(gene name synonym)|uniprotkb:PP4762(orf name) psi-mi:"MI:0071"(molecular sieving) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485983|imex:IM-17210-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 refseq:NP_001161337.1|refseq:NP_060085.2|ensembl:ENSG00000107672(gene)|ensembl:ENST00000369023(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR014854(Nse4)|interpro:IPR027786|interpro:IPR029225|reactome:R-HSA-3108214 go:"GO:0005634"(nucleus) - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:I9ZIuu6iHL5t2Gwjk9hgV6z1dlU9606 intact-crc:FD7F2F4FADB6F0DC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q8IY18 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605405|uniprotkb:A6NM81|uniprotkb:O60335|uniprotkb:Q05D92|uniprotkb:Q5VZ60|intact:EBI-1047898|uniprotkb:Q96SB9|ensembl:ENSP00000354957 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc5_human(display_long)|uniprotkb:SMC5(gene name)|psi-mi:SMC5(display_short)|uniprotkb:KIAA0594(gene name synonym)|uniprotkb:SMC5L1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485983|imex:IM-17210-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENST00000361138(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0034184"(positive regulation of maintenance of mitotic sister chromatid cohesion)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090398"(cellular senescence)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR027131|interpro:IPR027417|reactome:R-HSA-3108214|ensembl:ENSG00000198887(gene)|refseq:NP_055925.2 go:"GO:0005634"(nucleus) - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:eFzv6hXq8hKxGHPmp+yhMxbUyJ09606 intact-crc:FD7F2F4FADB6F0DC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WV22 uniprotkb:Q96SB8 intact:EBI-2557372|uniprotkb:Q9P049|uniprotkb:Q9P045|uniprotkb:D3DWF6|ensembl:ENSP00000355077 intact:EBI-605415|ensembl:ENSP00000323439|ensembl:ENSP00000384539|ensembl:ENSP00000404092|uniprotkb:Q05BV4|uniprotkb:Q9H0X3|uniprotkb:Q9H6M0|intact:EBI-2557379|uniprotkb:A8K8Q6|uniprotkb:D6W518 psi-mi:nse1_human(display_long)|uniprotkb:NSMCE1(gene name)|psi-mi:NSMCE1(display_short)|uniprotkb:HSPC333(orf name)|uniprotkb:HSPC337(orf name) psi-mi:smc6_human(display_long)|uniprotkb:SMC6(gene name)|psi-mi:SMC6(display_short)|uniprotkb:SMC6L1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Taylor et al. (2008) pubmed:18086888|imex:IM-17210 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-5485983|imex:IM-17210-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000169189(gene)|ensembl:ENST00000361439(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006301"(postreplication repair)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011513(Nse1 non-SMC component of SMC5-6 complex)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014857(Zinc finger, RING-like)|interpro:IPR036388|rcsb pdb:2CT0|rcsb pdb:5HVQ|reactome:R-HSA-3108214|rcsb pdb:5WY5|refseq:NP_659547.2|refseq:XP_006721086.1 ensembl:ENSG00000163029(gene)|ensembl:ENST00000351948(transcript)|ensembl:ENST00000402989(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|ensembl:ENST00000448223(transcript)|go:"GO:0030915"(Smc5-Smc6 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035061"(interchromatin granule)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0090398"(cellular senescence)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0000722"(telomere maintenance via recombination)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|go:"GO:0000724"(double-strand break repair via homologous recombination)|interpro:IPR027417|reactome:R-HSA-3108214|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000803"(sex chromosome)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|refseq:NP_001135758.1|refseq:NP_078900.1|refseq:XP_016860404.1|dip:DIP-34562N go:"GO:0005634"(nucleus) - - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/02/10 2014/10/16 rogid:9U8whAXZYSoYq8QX0aoP5i3FVZg9606 rogid:R9LrVYPHjbjxnSUVgDl8e8hqOtg9606 intact-crc:FD7F2F4FADB6F0DC|rigid:fsSadtWT5h6Zvgjz60+sutRGoNI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)