#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P06731 uniprotkb:P06731 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6471046|imex:IM-18169-4|mpidb:MPIDB-INT-1044|wwpdb:2qsq - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N - - - figure legend:Supp. Fig.1, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:ED5B4A5A73634C0C|rigid:Yk8x3grruSIllt+jjDeQnnRGdfM false mutation decreasing interaction strength:78-78|mutation decreasing interaction strength:78-78|mutation decreasing interaction strength:66-66|mutation decreasing interaction strength:68-68|mutation decreasing interaction strength:125-125|sufficient binding region:34-144|mutation decreasing interaction strength:63-63|mutation decreasing interaction strength:129-129|mutation decreasing interaction strength:133-133 mutation decreasing interaction strength:78-78|mutation decreasing interaction strength:78-78|mutation decreasing interaction strength:66-66|mutation decreasing interaction strength:68-68|mutation decreasing interaction strength:125-125|sufficient binding region:34-144|mutation decreasing interaction strength:63-63|mutation decreasing interaction strength:129-129|mutation decreasing interaction strength:133-133 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:P06731 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6471055|imex:IM-18169-5|mpidb:MPIDB-INT-1044|wwpdb:2qsq - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N - - - figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:9353C73331DE487C|rigid:6vgWrRmz/PR/EgI0E7ZfTO0r48M false sufficient binding region:34-144 sufficient binding region:34-144|mutation decreasing interaction strength:73-73 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:Q7BG35 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-6471155 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:q7bg35_ecolx(display_long)|uniprotkb:draE(gene name)|psi-mi:draE(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:562(ecolx)|taxid:562(Escherichia coli) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6471149|imex:IM-18169-8|mpidb:MPIDB-INT-1046|wwpdb:2qst - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:WP_063269203.1|interpro:IPR021020|interpro:IPR006713(Adhesin, Dr-family)|interpro:IPR008966(Adhesion, bacterial)|interpro:IPR037028 - - - figure legend:Fig4C-E|agonist:DTT|comment:DraE appears to disrupt N-CEA dimers prior to binding to the resulting monomer.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:R3CuDQrzpbbcOhfCro/oLM7c/AY562 intact-crc:2437BB92E1E7E9BB|rigid:QMxoMpHvKbx+SF553uDLizXe27o false mutation:73-73|sufficient binding region:34-144 - 2 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:P06731 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0029"(cosedimentation through density gradient) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6471104|mpidb:MPIDB-INT-1044|wwpdb:2qsq|imex:IM-18169-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N - - - figure legend:Supp. Fig.1, Table 2|3d-resolution:1.95A|3d-r-factors:Rworking = 0.18 Rfree = 0.2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.3x10^-5(molar) 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:5B29692326E98E38|rigid:Yk8x3grruSIllt+jjDeQnnRGdfM false mutation decreasing interaction strength:63-63|sufficient binding region:34-144|mutation decreasing interaction strength:129-129|mutation decreasing interaction strength:78-78|mutation decreasing interaction strength:125-125|mutation decreasing interaction strength:68-68|mutation decreasing interaction strength:66-66|mutation decreasing interaction strength:133-133 mutation decreasing interaction strength:63-63|sufficient binding region:34-144|mutation decreasing interaction strength:129-129|mutation decreasing interaction strength:78-78|mutation decreasing interaction strength:125-125|mutation decreasing interaction strength:68-68|mutation decreasing interaction strength:66-66|mutation decreasing interaction strength:133-133 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:Q57254 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-6401630 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:afae3_ecolx(display_long)|uniprotkb:afaE3(gene name)|psi-mi:afaE3(display_short)|uniprotkb:afaE-3(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:562(ecolx)|taxid:562(Escherichia coli) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0903"(mpidb) intact:EBI-6401635|mpidb:MPIDB-INT-1045|imex:IM-18169-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N go:"GO:0009289"(pilus)|interpro:IPR006713(Adhesin, Dr-family)|interpro:IPR008966(Adhesion, bacterial)|interpro:IPR021020|rcsb pdb:1RXL|rcsb pdb:1USZ|rcsb pdb:1UT2|rcsb pdb:2IXQ|rcsb pdb:2VER|interpro:IPR037028 - - - figure legend:Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:xkbQEBFFX5H/IiogDqNzwXKU3sw562 intact-crc:067A2BA5A320195B|rigid:pJ9+II31pW90oFULFI5N4tdv11I false mutation:52-52|mutation:54-54 15n label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:P06731 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0808"(comigration in sds page) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6471133|imex:IM-18169-7|mpidb:MPIDB-INT-1046|wwpdb:2qst - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N - - - figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:0600911D74F9B304|rigid:Yk8x3grruSIllt+jjDeQnnRGdfM false sufficient binding region:34-144|mutation:73-73 sufficient binding region:34-144|mutation:73-73 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:P06731 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6401625|mpidb:MPIDB-INT-1044|imex:IM-18169-1|wwpdb:2qsq - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N - - - figure legend:Table1|3d-resolution:1.95A|3d-r-factors:Rworking = 0.18 Rfree = 0.2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:5912A10225AC1314|rigid:Yk8x3grruSIllt+jjDeQnnRGdfM false sufficient binding region:34-144 sufficient binding region:34-144 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06731 uniprotkb:P06731 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 intact:EBI-3914938|intact:EBI-28983305|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|uniprotkb:H9KVA7 psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:ceam5_human(display_long)|uniprotkb:CEACAM5(gene name)|psi-mi:CEACAM5(display_short)|uniprotkb:CEA(gene name synonym)|uniprotkb:Carcinoembryonic antigen(gene name synonym)|uniprotkb:Meconium antigen 100(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Korotkova et al. (2008) pubmed:18086185|imex:IM-18169 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0903"(mpidb) intact:EBI-6401640|mpidb:MPIDB-INT-1046|imex:IM-18169-3|wwpdb:2qst - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N refseq:NP_001278413.1|refseq:NP_001295327.1|refseq:NP_004354.3|ensembl:ENSP00000221992|ensembl:ENSP00000381600|ensembl:ENSP00000385072|ensembl:ENSG00000105388(gene)|ensembl:ENST00000221992(transcript)|ensembl:ENST00000398599(transcript)|ensembl:ENST00000405816(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0009986"(cell surface)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0034235"(GPI anchor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071575"(integral component of external side of plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P06731|rcsb pdb:1E07|rcsb pdb:2QSQ|rcsb pdb:2QST|rcsb pdb:2VER|reactome:R-HSA-163125|reactome:R-HSA-202733|dip:DIP-57769N - - - figure legend:Table 1|3d-resolution:2.9A|3d-r-factors:Rworking = 0.22 Rfree = 0.25|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/11/30 2014/10/16 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 rogid:ka8w0sIIBXqHIhGkIlDva5yf5bI9606 intact-crc:A527DC22ADF40EC9|rigid:Yk8x3grruSIllt+jjDeQnnRGdfM false mutation:73-73|sufficient binding region:34-144 mutation:73-73|sufficient binding region:34-144 2 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)