#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13416	uniprotkb:Q9UBD5	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170476|imex:IM-17376-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 3A|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:F5143E1B3BB891F0|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	his tag:n-n	-	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:O43913	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170476|imex:IM-17376-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 3A|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:F5143E1B3BB891F0|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	his tag:n-n	-	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:Q13415	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170476|imex:IM-17376-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 3A|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:F5143E1B3BB891F0|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	his tag:n-n	-	1	-	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:O43929	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170476|imex:IM-17376-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 3A|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:F5143E1B3BB891F0|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	his tag:n-n	ha tag:n-n	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:Q9UBD5	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170393|imex:IM-17376-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1A, 1B|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:1B55637F74348CC4|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	his tag:n-n	-	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:O43913	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170393|imex:IM-17376-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1A, 1B|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:1B55637F74348CC4|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	his tag:n-n	-	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:O43929	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170393|imex:IM-17376-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 1A, 1B|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:1B55637F74348CC4|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	his tag:n-n	ha tag:n-n	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:Q9UBD5	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170462|imex:IM-17376-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 3A|comment:This sub-complex will assemble in the absence of ATP|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:221C55EBA4BD4BEC|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	his tag:n-n	-	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13416	uniprotkb:O43913	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170462|imex:IM-17376-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 3A|comment:This sub-complex will assemble in the absence of ATP|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:221C55EBA4BD4BEC|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	his tag:n-n	-	1	1	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q13415	uniprotkb:O43929	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170531|imex:IM-17376-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:B78B0A21AD9280FD|rigid:YAPyCB5G7I0jtnuoc2nPmoA0/jw	false	glutathione s tranferase tag:n-n|sufficient binding region:401-861	ha tag:n-n|35s radiolabel:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:O43913	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170531|imex:IM-17376-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:B78B0A21AD9280FD|rigid:YAPyCB5G7I0jtnuoc2nPmoA0/jw	false	glutathione s tranferase tag:n-n|sufficient binding region:401-861	35s radiolabel:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:O43913	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170547|imex:IM-17376-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig. 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:7A5B80CBE87EB93B|rigid:pLH6e/XLc/Vzg0oTMQ6586w9WRM	false	sufficient binding region:401-861|glutathione s tranferase tag:n-n	35s radiolabel:?-?|t7 tag:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:O43929	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170488|imex:IM-17376-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig. 3C, 4A, 4B, 4C|comment:ATP is required for the formation of a stable Orc1/Orc2/Orc3/Orc4/Orc5 complex, however mutations in Orc1 predicted to disrupt ATP binding or hydrolysis have no significant effect in complex formation in vitro.  ATP binding by Orc1 appears not to be essential for complex formation and may have other roles in DNA replication. Association of Orc1 with Orc2/Orc3/Orc5 is Orc4-dependent and requires a functional ATP-binding site in Orc4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:686698C481A569F6|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	sufficient binding region:401-861|glutathione s tranferase tag:n-n	ha tag:n-n|35s radiolabel:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:Q9UBD5	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170488|imex:IM-17376-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:Fig. 3C, 4A, 4B, 4C|comment:ATP is required for the formation of a stable Orc1/Orc2/Orc3/Orc4/Orc5 complex, however mutations in Orc1 predicted to disrupt ATP binding or hydrolysis have no significant effect in complex formation in vitro.  ATP binding by Orc1 appears not to be essential for complex formation and may have other roles in DNA replication. Association of Orc1 with Orc2/Orc3/Orc5 is Orc4-dependent and requires a functional ATP-binding site in Orc4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:686698C481A569F6|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	sufficient binding region:401-861|glutathione s tranferase tag:n-n	35s radiolabel:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:O43913	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170488|imex:IM-17376-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig. 3C, 4A, 4B, 4C|comment:ATP is required for the formation of a stable Orc1/Orc2/Orc3/Orc4/Orc5 complex, however mutations in Orc1 predicted to disrupt ATP binding or hydrolysis have no significant effect in complex formation in vitro.  ATP binding by Orc1 appears not to be essential for complex formation and may have other roles in DNA replication. Association of Orc1 with Orc2/Orc3/Orc5 is Orc4-dependent and requires a functional ATP-binding site in Orc4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:686698C481A569F6|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	sufficient binding region:401-861|glutathione s tranferase tag:n-n	t7 tag:?-?|35s radiolabel:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:Q13416	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170488|imex:IM-17376-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig. 3C, 4A, 4B, 4C|comment:ATP is required for the formation of a stable Orc1/Orc2/Orc3/Orc4/Orc5 complex, however mutations in Orc1 predicted to disrupt ATP binding or hydrolysis have no significant effect in complex formation in vitro.  ATP binding by Orc1 appears not to be essential for complex formation and may have other roles in DNA replication. Association of Orc1 with Orc2/Orc3/Orc5 is Orc4-dependent and requires a functional ATP-binding site in Orc4.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:686698C481A569F6|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	sufficient binding region:401-861|glutathione s tranferase tag:n-n	his tag:n-n|35s radiolabel:?-?	-	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:O43913	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170429|imex:IM-17376-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig. 1C, 2C|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:063F7E1B3D0A10A8|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	his tag:n-n|35s radiolabel:?-?	35s radiolabel:?-?|t7 tag:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:Q9UBD5	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170429|imex:IM-17376-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:Fig. 1C, 2C|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:063F7E1B3D0A10A8|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	his tag:n-n|35s radiolabel:?-?	35s radiolabel:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:O43929	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170429|imex:IM-17376-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig. 1C, 2C|comment:"ATP ( or a a nucleoside triphosphate analogue) is required for the formation of a stable Orc2/Orc3/Orc4/Orc5 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:063F7E1B3D0A10A8|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	his tag:n-n|35s radiolabel:?-?	ha tag:n-n|35s radiolabel:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:O43913	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6248556|imex:IM-17376-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig. 2C|comment:ORC5  Lys43Ala and Asp-Lys125-126Ala-Ala mutations which prevent ORC5 binding ATP prevent ORC5 binding to this complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:4A194573A1E3D6DD|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	35s radiolabel:?-?|his tag:n-n	t7 tag:?-?|35s radiolabel:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:Q9UBD5	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6248556|imex:IM-17376-27	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:Fig. 2C|comment:ORC5  Lys43Ala and Asp-Lys125-126Ala-Ala mutations which prevent ORC5 binding ATP prevent ORC5 binding to this complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:4A194573A1E3D6DD|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	35s radiolabel:?-?|his tag:n-n	35s radiolabel:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:Q9UBD5	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170448|imex:IM-17376-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:Fig. 2B|comment:ORC4 Lys73Ala, Lys73Glu, or Asp_Glu159-160Ala_Ala mutations which stop ORC4 binding ATP also prevent ORC4 binding to this complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:812A43A8185B68AA|rigid:5GLUL8JXaqmcJKVXsyEM24T9Juo	false	35s radiolabel:?-?|his tag:n-n	35s radiolabel:?-?	1	1	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13416	uniprotkb:O43929	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170448|imex:IM-17376-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig. 2B|comment:ORC4 Lys73Ala, Lys73Glu, or Asp_Glu159-160Ala_Ala mutations which stop ORC4 binding ATP also prevent ORC4 binding to this complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:812A43A8185B68AA|rigid:5GLUL8JXaqmcJKVXsyEM24T9Juo	false	35s radiolabel:?-?|his tag:n-n	ha tag:n-n|35s radiolabel:?-?	1	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9UBD5	uniprotkb:Q9Y5N6	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374840|ensembl:ENSP00000219097|uniprotkb:B3KN89	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc6_human(display_long)|uniprotkb:ORC6(gene name)|psi-mi:ORC6(display_short)|uniprotkb:ORC6L(gene name synonym)	psi-mi:"MI:0096"(pull down)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170751|imex:IM-17376-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000091651(gene)|ensembl:ENST00000219097(transcript)|go:"GO:0000808"(origin recognition complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0051782"(negative regulation of cell division)|interpro:IPR008721(Origin recognition complex subunit 6)|interpro:IPR020529|mint:Q9Y5N6|rcsb pdb:3M03|rcsb pdb:6KVG|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_055136.1|dip:DIP-29692N	-	-	-	figure legend:Fig. 7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:WElR6cWK58+oULzC4OgHBDVgikc9606	intact-crc:B7EC86E465691E34|rigid:O+/RH6LBRqRU7eiNywQmXLAFY1Y	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q13415	uniprotkb:Q13416	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170567|imex:IM-17376-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:97CD0DA0417C5C13|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	flag tag:?-?|necessary binding region:501-600	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:O43913	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170567|imex:IM-17376-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:97CD0DA0417C5C13|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	flag tag:?-?|necessary binding region:501-600	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:O43929	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170567|imex:IM-17376-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:97CD0DA0417C5C13|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	flag tag:?-?|necessary binding region:501-600	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:Q9UBD5	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170567|imex:IM-17376-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:Fig. 5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:97CD0DA0417C5C13|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	flag tag:?-?|necessary binding region:501-600	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43929	uniprotkb:Q13416	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170726|imex:IM-17376-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:3A2182658A64CB6D|rigid:5GLUL8JXaqmcJKVXsyEM24T9Juo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43929	uniprotkb:Q9UBD5	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170726|imex:IM-17376-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:3A2182658A64CB6D|rigid:5GLUL8JXaqmcJKVXsyEM24T9Juo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170714|imex:IM-17376-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:BC4B24CA972795FA|rigid:X1qnVSCvXtHFHQPsjxXJE3Lkais	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q9Y5N6	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374840|ensembl:ENSP00000219097|uniprotkb:B3KN89	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc6_human(display_long)|uniprotkb:ORC6(gene name)|psi-mi:ORC6(display_short)|uniprotkb:ORC6L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170714|imex:IM-17376-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000091651(gene)|ensembl:ENST00000219097(transcript)|go:"GO:0000808"(origin recognition complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0051782"(negative regulation of cell division)|interpro:IPR008721(Origin recognition complex subunit 6)|interpro:IPR020529|mint:Q9Y5N6|rcsb pdb:3M03|rcsb pdb:6KVG|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_055136.1|dip:DIP-29692N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:WElR6cWK58+oULzC4OgHBDVgikc9606	intact-crc:BC4B24CA972795FA|rigid:X1qnVSCvXtHFHQPsjxXJE3Lkais	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170714|imex:IM-17376-22	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:BC4B24CA972795FA|rigid:X1qnVSCvXtHFHQPsjxXJE3Lkais	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170742|imex:IM-17376-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7B|comment:Low levels of ORC6 was seen in the interaction suggesting that a large fraction of Orc6 was not associated with the ORC complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:B6200A2E34F41748|rigid:7CsLHH+mab0x0O1tqc8LADXqEEw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q9Y5N6	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374840|ensembl:ENSP00000219097|uniprotkb:B3KN89	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc6_human(display_long)|uniprotkb:ORC6(gene name)|psi-mi:ORC6(display_short)|uniprotkb:ORC6L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170742|imex:IM-17376-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000091651(gene)|ensembl:ENST00000219097(transcript)|go:"GO:0000808"(origin recognition complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0051782"(negative regulation of cell division)|interpro:IPR008721(Origin recognition complex subunit 6)|interpro:IPR020529|mint:Q9Y5N6|rcsb pdb:3M03|rcsb pdb:6KVG|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_055136.1|dip:DIP-29692N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7B|comment:Low levels of ORC6 was seen in the interaction suggesting that a large fraction of Orc6 was not associated with the ORC complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:WElR6cWK58+oULzC4OgHBDVgikc9606	intact-crc:B6200A2E34F41748|rigid:7CsLHH+mab0x0O1tqc8LADXqEEw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170742|imex:IM-17376-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7B|comment:Low levels of ORC6 was seen in the interaction suggesting that a large fraction of Orc6 was not associated with the ORC complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:B6200A2E34F41748|rigid:7CsLHH+mab0x0O1tqc8LADXqEEw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170742|imex:IM-17376-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7B|comment:Low levels of ORC6 was seen in the interaction suggesting that a large fraction of Orc6 was not associated with the ORC complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:B6200A2E34F41748|rigid:7CsLHH+mab0x0O1tqc8LADXqEEw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170742|imex:IM-17376-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7B|comment:Low levels of ORC6 was seen in the interaction suggesting that a large fraction of Orc6 was not associated with the ORC complex.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:B6200A2E34F41748|rigid:7CsLHH+mab0x0O1tqc8LADXqEEw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170594|imex:IM-17376-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:C3110D25D162187C|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170594|imex:IM-17376-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:C3110D25D162187C|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	necessary binding region:501-600|flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170594|imex:IM-17376-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:C3110D25D162187C|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170594|imex:IM-17376-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:C3110D25D162187C|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43913	uniprotkb:Q13416	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170732|imex:IM-17376-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:25DD0F83BCDA162E|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43913	uniprotkb:Q9UBD5	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170732|imex:IM-17376-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:25DD0F83BCDA162E|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43913	uniprotkb:O43929	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170732|imex:IM-17376-24	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig.7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/06/27	2014/10/16	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:25DD0F83BCDA162E|rigid:vOaRgXWPttRehFf3dEUHMiNSz0w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170708|imex:IM-17376-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:4DCC1CC28CE862DE|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170708|imex:IM-17376-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:10|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:4DCC1CC28CE862DE|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170690|imex:IM-17376-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:E0D90C3534915AC5|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170690|imex:IM-17376-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:E0D90C3534915AC5|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170702|imex:IM-17376-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:EAD9AC3534915AC5|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170702|imex:IM-17376-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:EAD9AC3534915AC5|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170696|imex:IM-17376-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:EB02DC3534915AC5|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170696|imex:IM-17376-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:EB02DC3534915AC5|rigid:8xUMwDWkPQ02lcTet5vqBrvkSIk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170666|imex:IM-17376-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:EC6222F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170666|imex:IM-17376-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:EC6222F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170666|imex:IM-17376-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:EC6222F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170666|imex:IM-17376-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:EC6222F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170654|imex:IM-17376-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:A1258969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170654|imex:IM-17376-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:A1258969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170654|imex:IM-17376-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:A1258969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170654|imex:IM-17376-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:A1258969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170674|imex:IM-17376-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:EDB952F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170674|imex:IM-17376-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:EDB952F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170674|imex:IM-17376-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:EDB952F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170674|imex:IM-17376-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:EDB952F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170642|imex:IM-17376-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:A0FEF969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170642|imex:IM-17376-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:A0FEF969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170642|imex:IM-17376-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:A0FEF969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170642|imex:IM-17376-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:A0FEF969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170630|imex:IM-17376-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:A2936969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170630|imex:IM-17376-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:A2936969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170630|imex:IM-17376-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:A2936969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170630|imex:IM-17376-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:A2936969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170616|imex:IM-17376-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:0|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:A3481969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170616|imex:IM-17376-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:0|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:A3481969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170616|imex:IM-17376-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:0|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:A3481969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170616|imex:IM-17376-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:0|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:A3481969DB88E3AD|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43929	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374889|uniprotkb:B7Z5F1|uniprotkb:F5H069|uniprotkb:Q96C42|ensembl:ENSP00000264169|ensembl:ENSP00000376597|ensembl:ENSP00000441953|uniprotkb:D3DP86|uniprotkb:B7Z3D0	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc4_human(display_long)|uniprotkb:ORC4(gene name)|psi-mi:ORC4(display_short)|uniprotkb:ORC4L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170682|imex:IM-17376-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115947(gene)|ensembl:ENST00000264169(transcript)|ensembl:ENST00000392857(transcript)|ensembl:ENST00000535373(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR016527(Origin recognition complex, subunit 4)|interpro:IPR027417|interpro:IPR032705|interpro:IPR041664|mint:O43929|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_011509557.1|refseq:NP_001177808.1|refseq:NP_002543.2|refseq:NP_859525.1|refseq:NP_859526.1|refseq:XP_016859715.1|refseq:NP_001177810.1|refseq:NP_001177811.1|refseq:XP_016859716.1|dip:DIP-29690N	-	-	-	figure legend:Fig.6B|variable_condition:6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:fo+Suy/Q9ElX4ryKHMSH+Jzkpfs9606	intact-crc:EFD4C2F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:O43913	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170682|imex:IM-17376-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	-	-	-	figure legend:Fig.6B|variable_condition:6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	intact-crc:EFD4C2F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13416	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170682|imex:IM-17376-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	-	-	-	figure legend:Fig.6B|variable_condition:6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	intact-crc:EFD4C2F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UBD5	uniprotkb:Q13415	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Siddiqui et al. (2007)	imex:IM-17376|pubmed:17716973	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6170682|imex:IM-17376-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	-	-	-	figure legend:Fig.6B|variable_condition:6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/06/27	2014/10/16	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	intact-crc:EFD4C2F2BA4A7C16|rigid:CkS8xMhXIco8b3YrfIeoPdOl+yw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)