#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:F8VQB6 uniprotkb:P97798 intact:EBI-6445959|uniprotkb:Q8R3S0|uniprotkb:Q9JJY5|ensembl:ENSMUSP00000106087 intact:EBI-774991 psi-mi:myo10_mouse(display_long)|uniprotkb:Myo10(gene name)|psi-mi:Myo10(display_short)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2007) imex:IM-18844|pubmed:17237772 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6465703|imex:IM-18844-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022272(gene)|ensembl:ENSMUST00000110457(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|reactome:R-MMU-2029482|refseq:NP_062345.2|refseq:XP_006520088.1 dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane) - - - figure legend:Fig 1g.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2012/12/19 2014/10/16 rogid:FjRMmaaoqmy1xIhpHA/QyPoNhpE10090 rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090 intact-crc:A5073B7DBFB6F3F0|rigid:LlbdXzKTRarSg6M8ZSOh7kPoVZM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:F8VQB6 uniprotkb:P70211 intact:EBI-6445959|uniprotkb:Q8R3S0|uniprotkb:Q9JJY5|ensembl:ENSMUSP00000106087 intact:EBI-1798863|uniprotkb:G3X9X6|ensembl:ENSMUSP00000110593 psi-mi:myo10_mouse(display_long)|uniprotkb:Myo10(gene name)|psi-mi:Myo10(display_short)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:dcc_mouse(display_long)|uniprotkb:Dcc(gene name)|psi-mi:Dcc(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2007) imex:IM-18844|pubmed:17237772 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6465703|imex:IM-18844-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022272(gene)|ensembl:ENSMUST00000110457(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|reactome:R-MMU-2029482|refseq:NP_062345.2|refseq:XP_006520088.1 refseq:XP_006525651.1|refseq:NP_031857.2|dip:DIP-46587N|ensembl:ENSMUSG00000060534(gene)|ensembl:ENSMUST00000114943(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0032584"(growth cone membrane)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|mint:P70211|rcsb pdb:3PZD|rcsb pdb:4PLO|reactome:R-MMU-373752|reactome:R-MMU-418885|reactome:R-MMU-418889 - - - figure legend:Fig 1g.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2012/12/19 2014/10/16 rogid:FjRMmaaoqmy1xIhpHA/QyPoNhpE10090 rogid:EMyR8LhWLCvJIBIAEn9dULe8Xfo10090 intact-crc:A5073B7DBFB6F3F0|rigid:LlbdXzKTRarSg6M8ZSOh7kPoVZM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:F8VQB6 uniprotkb:P97798 intact:EBI-6445959|uniprotkb:Q8R3S0|uniprotkb:Q9JJY5|ensembl:ENSMUSP00000106087 intact:EBI-774991 psi-mi:myo10_mouse(display_long)|uniprotkb:Myo10(gene name)|psi-mi:Myo10(display_short)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym) psi-mi:"MI:0096"(pull down) Zhu et al. (2007) imex:IM-18844|pubmed:17237772 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6465717|imex:IM-18844-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022272(gene)|ensembl:ENSMUST00000110457(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|reactome:R-MMU-2029482|refseq:NP_062345.2|refseq:XP_006520088.1 dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane) - - - figure legend:Fig 1b, 1d.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/19 2014/10/16 rogid:FjRMmaaoqmy1xIhpHA/QyPoNhpE10090 rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090 intact-crc:A59B420CDF30E791|rigid:UqU4lfAjE88DfFLEuwa1um7h5q0 false necessary binding region:1584-2062 glutathione s tranferase tag:?-?|sufficient binding region:1158-1493 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:F8VQB6 uniprotkb:P97798 intact:EBI-6445959|uniprotkb:Q8R3S0|uniprotkb:Q9JJY5|ensembl:ENSMUSP00000106087 intact:EBI-774991 psi-mi:myo10_mouse(display_long)|uniprotkb:Myo10(gene name)|psi-mi:Myo10(display_short)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:neo1_mouse(display_long)|uniprotkb:Neo1(gene name)|psi-mi:Neo1(display_short)|uniprotkb:Ngn(gene name synonym) psi-mi:"MI:0018"(two hybrid) Zhu et al. (2007) imex:IM-18844|pubmed:17237772 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1222"(mbinfo) intact:EBI-6465735|imex:IM-18844-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022272(gene)|ensembl:ENSMUST00000110457(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|reactome:R-MMU-2029482|refseq:NP_062345.2|refseq:XP_006520088.1 dip:DIP-32026N|mint:P97798|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033024|interpro:IPR036116|interpro:IPR036179|rcsb pdb:4BQ6|rcsb pdb:4BQ7|rcsb pdb:4BQ8|rcsb pdb:4BQ9|rcsb pdb:4BQB|rcsb pdb:4BQC|rcsb pdb:4PLN|rcsb pdb:4UI2|rcsb pdb:6Z3M|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009986"(cell surface)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0039706"(co-receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR003598(Immunoglobulin subtype 2)|go:"GO:0016020"(membrane) - - - figure legend:Fig 1c.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2012/12/19 2014/10/16 rogid:FjRMmaaoqmy1xIhpHA/QyPoNhpE10090 rogid:aXMUxah5/WOetOEQwj+mci65/Fo10090 intact-crc:0FCE3DFE37F3633E|rigid:UqU4lfAjE88DfFLEuwa1um7h5q0 false sufficient binding region:860-2062 necessary binding region:1413-1493 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q63155 uniprotkb:F8VQB6 intact:EBI-1798965 intact:EBI-6445959|uniprotkb:Q8R3S0|uniprotkb:Q9JJY5|ensembl:ENSMUSP00000106087 psi-mi:dcc_rat(display_long)|uniprotkb:Dcc(gene name)|psi-mi:Dcc(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym) psi-mi:myo10_mouse(display_long)|uniprotkb:Myo10(gene name)|psi-mi:Myo10(display_short)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Zhu et al. (2007) imex:IM-18844|pubmed:17237772 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1222"(mbinfo) intact:EBI-6465752|imex:IM-18844-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:2492|refseq:NP_036973.1|dip:DIP-46811N|reactome:R-RNO-373752|reactome:R-RNO-418885|reactome:R-RNO-418889|go:"GO:0001764"(neuron migration)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0032584"(growth cone membrane)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|rcsb pdb:3LAF|rcsb pdb:3O71|rcsb pdb:5Z5K|rcsb pdb:6BZ3 ensembl:ENSMUSG00000022272(gene)|ensembl:ENSMUST00000110457(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|reactome:R-MMU-2029482|refseq:NP_062345.2|refseq:XP_006520088.1 go:"GO:0043005"(neuron projection)|go:"GO:0032433"(filopodium tip) - - figure legend:Fig 2a, S2b.|comment:"DCC was not colocalized in neurites with Myosin X in cells transfected with MyoX-delta tail (Myosin X lacking the tail region)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10114(rat-cortical_neuron)|taxid:10114(Rat cortical Neurons) - 2012/12/19 2014/10/16 rogid:f9bBlRhCIGay3wVNWUCZ46hmyb010116 rogid:FjRMmaaoqmy1xIhpHA/QyPoNhpE10090 intact-crc:EA5E808636C74337|rigid:8kpC2cdXsKZeEgH2pxFioH60geI false - green fluorescent protein tag:?-?|necessary binding region:1584-2062 - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P70211 uniprotkb:F8VQB6 intact:EBI-1798863|uniprotkb:G3X9X6|ensembl:ENSMUSP00000110593 intact:EBI-6445959|uniprotkb:Q8R3S0|uniprotkb:Q9JJY5|ensembl:ENSMUSP00000106087 psi-mi:dcc_mouse(display_long)|uniprotkb:Dcc(gene name)|psi-mi:Dcc(display_short)|uniprotkb:Tumor suppressor protein DCC(gene name synonym) psi-mi:myo10_mouse(display_long)|uniprotkb:Myo10(gene name)|psi-mi:Myo10(display_short)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Zhu et al. (2007) imex:IM-18844|pubmed:17237772 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1222"(mbinfo) intact:EBI-6465772|imex:IM-18844-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006525651.1|refseq:NP_031857.2|dip:DIP-46587N|ensembl:ENSMUSG00000060534(gene)|ensembl:ENSMUST00000114943(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005042"(netrin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007411"(axon guidance)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021965"(spinal cord ventral commissure morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0032584"(growth cone membrane)|go:"GO:0033563"(dorsal/ventral axon guidance)|go:"GO:0033564"(anterior/posterior axon guidance)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:1901214"(regulation of neuron death)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR010560(Neogenin, C-terminal)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033012|interpro:IPR036116|interpro:IPR036179|mint:P70211|rcsb pdb:3PZD|rcsb pdb:4PLO|reactome:R-MMU-373752|reactome:R-MMU-418885|reactome:R-MMU-418889 ensembl:ENSMUSG00000022272(gene)|ensembl:ENSMUST00000110457(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048870"(cell motility)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|reactome:R-MMU-2029482|refseq:NP_062345.2|refseq:XP_006520088.1 go:"GO:0030175"(filopodium) - - figure legend:Fig 3a.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2012/12/19 2014/10/16 rogid:EMyR8LhWLCvJIBIAEn9dULe8Xfo10090 rogid:FjRMmaaoqmy1xIhpHA/QyPoNhpE10090 intact-crc:E958A851B61FF851|rigid:5W/y0TpntlmfUTDfw/i9Q3hU0lA false - green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)