#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NX02	uniprotkb:Q56P42	intact:EBI-6374482|uniprotkb:Q8IXT0|uniprotkb:Q9BVN5|uniprotkb:Q9H6G6|uniprotkb:Q9HAV9|uniprotkb:Q9NWK3|uniprotkb:Q53FL5|uniprotkb:Q59G09|intact:EBI-28979473|ensembl:ENSP00000409370|ensembl:ENSP00000445135|ensembl:ENSP00000478265|ensembl:ENSP00000478450|ensembl:ENSP00000478774|ensembl:ENSP00000478876|ensembl:ENSP00000479109|ensembl:ENSP00000479220|ensembl:ENSP00000479352|ensembl:ENSP00000479713|ensembl:ENSP00000479783|ensembl:ENSP00000481851|ensembl:ENSP00000482253|ensembl:ENSP00000482889|ensembl:ENSP00000483281|ensembl:ENSP00000483528|ensembl:ENSP00000483963|ensembl:ENSP00000484354|uniprotkb:B4DZL7|uniprotkb:I3L0G4	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:nalp2_human(display_long)|uniprotkb:NLRP2(gene name)|psi-mi:NLRP2(display_short)|uniprotkb:NALP2(gene name synonym)|uniprotkb:NBS1(gene name synonym)|uniprotkb:PAN1(gene name synonym)|uniprotkb:PYPAF2(gene name synonym)|uniprotkb:Nucleotide-binding site protein 1(gene name synonym)|uniprotkb:PYRIN domain and NACHT domain-containing protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 2(gene name synonym)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167552.1|refseq:NP_060322.1|refseq:NP_001167553.1|refseq:NP_001167554.1|ensembl:ENSG00000022556(gene)|ensembl:ENSG00000273992(gene)|ensembl:ENSG00000274638(gene)|ensembl:ENSG00000275082(gene)|ensembl:ENSG00000275399(gene)|ensembl:ENSG00000275796(gene)|ensembl:ENSG00000275843(gene)|ensembl:ENSG00000278682(gene)|ensembl:ENSG00000278789(gene)|ensembl:ENST00000448584(transcript)|ensembl:ENST00000543010(transcript)|ensembl:ENST00000611410(transcript)|ensembl:ENST00000611679(transcript)|ensembl:ENST00000611772(transcript)|ensembl:ENST00000613062(transcript)|ensembl:ENST00000613825(transcript)|ensembl:ENST00000615173(transcript)|ensembl:ENST00000615391(transcript)|ensembl:ENST00000615521(transcript)|ensembl:ENST00000616040(transcript)|ensembl:ENST00000619281(transcript)|ensembl:ENST00000619454(transcript)|ensembl:ENST00000619664(transcript)|ensembl:ENST00000621200(transcript)|ensembl:ENST00000621239(transcript)|ensembl:ENST00000621594(transcript)|ensembl:ENST00000622042(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9NX02|ensembl:ENSP00000483963|ensembl:ENSP00000484351|ensembl:ENST00000613851|ensembl:ENSP00000482628|ensembl:ENSP00000482889|ensembl:ENSP00000481851|ensembl:ENSP00000479352|ensembl:ENSP00000478876|ensembl:ENST00000616903|ensembl:ENSP00000482355|ensembl:ENST00000616919|ensembl:ENSP00000481564|ensembl:ENST00000618018|ensembl:ENSP00000483886|ensembl:ENST00000618694|ensembl:ENSP00000482465|ensembl:ENST00000618731|ensembl:ENSP00000478787|ensembl:ENST00000618789|ensembl:ENSP00000478318|ensembl:ENST00000618943|ensembl:ENSP00000482309|ensembl:ENSP00000478265|ensembl:ENSP00000483528|ensembl:ENSP00000478774|ensembl:ENST00000619885|ensembl:ENSP00000483389|ensembl:ENST00000621057|ensembl:ENSP00000484382|ensembl:ENSP00000479783|ensembl:ENSP00000479713|ensembl:ENSP00000478450|ensembl:ENSP00000482253|ensembl:ENST00000622216|ensembl:ENSP00000482044|ensembl:ENST00000622444|ensembl:ENSP00000482065|ensembl:ENST00000622600|ensembl:ENSP00000482727|ensembl:ENST00000622773|ensembl:ENSP00000484759|ensembl:ENST00000622864|ensembl:ENSP00000477726|ensembl:ENST00000339757|ensembl:ENSP00000344074|ensembl:ENST00000391721|ensembl:ENSP00000375601|ensembl:ENST00000427260|ensembl:ENSP00000402474|ensembl:ENSP00000409370|ensembl:ENST00000537859|ensembl:ENSP00000440601|ensembl:ENSP00000445135|ensembl:ENSP00000479220|ensembl:ENST00000611642|ensembl:ENSP00000484150|ensembl:ENST00000611676|ensembl:ENSP00000481999|ensembl:ENSP00000484354|ensembl:ENSP00000479109|ensembl:ENSP00000483281|ensembl:ENST00000613485|refseq:NP_001334932.1|dip:DIP-42460N	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	-	-	-	figure legend:3A|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/23	2014/10/16	rogid:+AKz+b3v1+2sdqYqiEUVjyIpVrw9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:AF4C6D1E5F0B610C|rigid:6gjIFaDq0pPUF/JwqF67hs+wgzY	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q56P42	uniprotkb:Q9ULZ3	intact:EBI-6374418|ensembl:ENSP00000492367	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0096"(pull down)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374431	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	-	-	-	figure legend:3A|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/23	2014/10/16	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:D02236996454081D|rigid:UP6conNrWlJuOey9XpMa5DEnMeA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q56P42	uniprotkb:Q9ULZ3	intact:EBI-6374418|ensembl:ENSP00000492367	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	-	-	-	figure legend:3B|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:184928375D5C814D|rigid:UP6conNrWlJuOey9XpMa5DEnMeA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8WXC3	uniprotkb:Q9ULZ3	intact:EBI-6374437|uniprotkb:B2R8L4|uniprotkb:Q8NFP8|ensembl:ENSP00000304336	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:pydc1_human(display_long)|uniprotkb:PYDC1(gene name)|psi-mi:PYDC1(display_short)|uniprotkb:ASC2(gene name synonym)|uniprotkb:ASCI(gene name synonym)|uniprotkb:POP1(gene name synonym)|uniprotkb:PYC1(gene name synonym)|uniprotkb:PAAD-only protein 1(gene name synonym)|uniprotkb:Pyrin-only protein 1(gene name synonym)|uniprotkb:cellular POP1(gene name synonym)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_690865.1|ensembl:ENSG00000169900(gene)|ensembl:ENST00000302964(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0045087"(innate immune response)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|rcsb pdb:2HM2|rcsb pdb:4QOB	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	-	-	-	figure legend:3B|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:W3Zmdd03z5PKG2e0K9/a16kGd409606	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:DA88FA8E407E7749|rigid:1qVQZLtSGMa2fNuh5z0GTUfn+tc	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NX02	uniprotkb:Q56P42	intact:EBI-6374482|uniprotkb:Q8IXT0|uniprotkb:Q9BVN5|uniprotkb:Q9H6G6|uniprotkb:Q9HAV9|uniprotkb:Q9NWK3|uniprotkb:Q53FL5|uniprotkb:Q59G09|intact:EBI-28979473|ensembl:ENSP00000409370|ensembl:ENSP00000445135|ensembl:ENSP00000478265|ensembl:ENSP00000478450|ensembl:ENSP00000478774|ensembl:ENSP00000478876|ensembl:ENSP00000479109|ensembl:ENSP00000479220|ensembl:ENSP00000479352|ensembl:ENSP00000479713|ensembl:ENSP00000479783|ensembl:ENSP00000481851|ensembl:ENSP00000482253|ensembl:ENSP00000482889|ensembl:ENSP00000483281|ensembl:ENSP00000483528|ensembl:ENSP00000483963|ensembl:ENSP00000484354|uniprotkb:B4DZL7|uniprotkb:I3L0G4	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:nalp2_human(display_long)|uniprotkb:NLRP2(gene name)|psi-mi:NLRP2(display_short)|uniprotkb:NALP2(gene name synonym)|uniprotkb:NBS1(gene name synonym)|uniprotkb:PAN1(gene name synonym)|uniprotkb:PYPAF2(gene name synonym)|uniprotkb:Nucleotide-binding site protein 1(gene name synonym)|uniprotkb:PYRIN domain and NACHT domain-containing protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 2(gene name synonym)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167552.1|refseq:NP_060322.1|refseq:NP_001167553.1|refseq:NP_001167554.1|ensembl:ENSG00000022556(gene)|ensembl:ENSG00000273992(gene)|ensembl:ENSG00000274638(gene)|ensembl:ENSG00000275082(gene)|ensembl:ENSG00000275399(gene)|ensembl:ENSG00000275796(gene)|ensembl:ENSG00000275843(gene)|ensembl:ENSG00000278682(gene)|ensembl:ENSG00000278789(gene)|ensembl:ENST00000448584(transcript)|ensembl:ENST00000543010(transcript)|ensembl:ENST00000611410(transcript)|ensembl:ENST00000611679(transcript)|ensembl:ENST00000611772(transcript)|ensembl:ENST00000613062(transcript)|ensembl:ENST00000613825(transcript)|ensembl:ENST00000615173(transcript)|ensembl:ENST00000615391(transcript)|ensembl:ENST00000615521(transcript)|ensembl:ENST00000616040(transcript)|ensembl:ENST00000619281(transcript)|ensembl:ENST00000619454(transcript)|ensembl:ENST00000619664(transcript)|ensembl:ENST00000621200(transcript)|ensembl:ENST00000621239(transcript)|ensembl:ENST00000621594(transcript)|ensembl:ENST00000622042(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9NX02|ensembl:ENSP00000483963|ensembl:ENSP00000484351|ensembl:ENST00000613851|ensembl:ENSP00000482628|ensembl:ENSP00000482889|ensembl:ENSP00000481851|ensembl:ENSP00000479352|ensembl:ENSP00000478876|ensembl:ENST00000616903|ensembl:ENSP00000482355|ensembl:ENST00000616919|ensembl:ENSP00000481564|ensembl:ENST00000618018|ensembl:ENSP00000483886|ensembl:ENST00000618694|ensembl:ENSP00000482465|ensembl:ENST00000618731|ensembl:ENSP00000478787|ensembl:ENST00000618789|ensembl:ENSP00000478318|ensembl:ENST00000618943|ensembl:ENSP00000482309|ensembl:ENSP00000478265|ensembl:ENSP00000483528|ensembl:ENSP00000478774|ensembl:ENST00000619885|ensembl:ENSP00000483389|ensembl:ENST00000621057|ensembl:ENSP00000484382|ensembl:ENSP00000479783|ensembl:ENSP00000479713|ensembl:ENSP00000478450|ensembl:ENSP00000482253|ensembl:ENST00000622216|ensembl:ENSP00000482044|ensembl:ENST00000622444|ensembl:ENSP00000482065|ensembl:ENST00000622600|ensembl:ENSP00000482727|ensembl:ENST00000622773|ensembl:ENSP00000484759|ensembl:ENST00000622864|ensembl:ENSP00000477726|ensembl:ENST00000339757|ensembl:ENSP00000344074|ensembl:ENST00000391721|ensembl:ENSP00000375601|ensembl:ENST00000427260|ensembl:ENSP00000402474|ensembl:ENSP00000409370|ensembl:ENST00000537859|ensembl:ENSP00000440601|ensembl:ENSP00000445135|ensembl:ENSP00000479220|ensembl:ENST00000611642|ensembl:ENSP00000484150|ensembl:ENST00000611676|ensembl:ENSP00000481999|ensembl:ENSP00000484354|ensembl:ENSP00000479109|ensembl:ENSP00000483281|ensembl:ENST00000613485|refseq:NP_001334932.1|dip:DIP-42460N	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	-	-	-	figure legend:3C|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:+AKz+b3v1+2sdqYqiEUVjyIpVrw9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:296306EAA7570820|rigid:6gjIFaDq0pPUF/JwqF67hs+wgzY	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NX02	uniprotkb:Q56P42	intact:EBI-6374482|uniprotkb:Q8IXT0|uniprotkb:Q9BVN5|uniprotkb:Q9H6G6|uniprotkb:Q9HAV9|uniprotkb:Q9NWK3|uniprotkb:Q53FL5|uniprotkb:Q59G09|intact:EBI-28979473|ensembl:ENSP00000409370|ensembl:ENSP00000445135|ensembl:ENSP00000478265|ensembl:ENSP00000478450|ensembl:ENSP00000478774|ensembl:ENSP00000478876|ensembl:ENSP00000479109|ensembl:ENSP00000479220|ensembl:ENSP00000479352|ensembl:ENSP00000479713|ensembl:ENSP00000479783|ensembl:ENSP00000481851|ensembl:ENSP00000482253|ensembl:ENSP00000482889|ensembl:ENSP00000483281|ensembl:ENSP00000483528|ensembl:ENSP00000483963|ensembl:ENSP00000484354|uniprotkb:B4DZL7|uniprotkb:I3L0G4	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:nalp2_human(display_long)|uniprotkb:NLRP2(gene name)|psi-mi:NLRP2(display_short)|uniprotkb:NALP2(gene name synonym)|uniprotkb:NBS1(gene name synonym)|uniprotkb:PAN1(gene name synonym)|uniprotkb:PYPAF2(gene name synonym)|uniprotkb:Nucleotide-binding site protein 1(gene name synonym)|uniprotkb:PYRIN domain and NACHT domain-containing protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 2(gene name synonym)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374575	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167552.1|refseq:NP_060322.1|refseq:NP_001167553.1|refseq:NP_001167554.1|ensembl:ENSG00000022556(gene)|ensembl:ENSG00000273992(gene)|ensembl:ENSG00000274638(gene)|ensembl:ENSG00000275082(gene)|ensembl:ENSG00000275399(gene)|ensembl:ENSG00000275796(gene)|ensembl:ENSG00000275843(gene)|ensembl:ENSG00000278682(gene)|ensembl:ENSG00000278789(gene)|ensembl:ENST00000448584(transcript)|ensembl:ENST00000543010(transcript)|ensembl:ENST00000611410(transcript)|ensembl:ENST00000611679(transcript)|ensembl:ENST00000611772(transcript)|ensembl:ENST00000613062(transcript)|ensembl:ENST00000613825(transcript)|ensembl:ENST00000615173(transcript)|ensembl:ENST00000615391(transcript)|ensembl:ENST00000615521(transcript)|ensembl:ENST00000616040(transcript)|ensembl:ENST00000619281(transcript)|ensembl:ENST00000619454(transcript)|ensembl:ENST00000619664(transcript)|ensembl:ENST00000621200(transcript)|ensembl:ENST00000621239(transcript)|ensembl:ENST00000621594(transcript)|ensembl:ENST00000622042(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9NX02|ensembl:ENSP00000483963|ensembl:ENSP00000484351|ensembl:ENST00000613851|ensembl:ENSP00000482628|ensembl:ENSP00000482889|ensembl:ENSP00000481851|ensembl:ENSP00000479352|ensembl:ENSP00000478876|ensembl:ENST00000616903|ensembl:ENSP00000482355|ensembl:ENST00000616919|ensembl:ENSP00000481564|ensembl:ENST00000618018|ensembl:ENSP00000483886|ensembl:ENST00000618694|ensembl:ENSP00000482465|ensembl:ENST00000618731|ensembl:ENSP00000478787|ensembl:ENST00000618789|ensembl:ENSP00000478318|ensembl:ENST00000618943|ensembl:ENSP00000482309|ensembl:ENSP00000478265|ensembl:ENSP00000483528|ensembl:ENSP00000478774|ensembl:ENST00000619885|ensembl:ENSP00000483389|ensembl:ENST00000621057|ensembl:ENSP00000484382|ensembl:ENSP00000479783|ensembl:ENSP00000479713|ensembl:ENSP00000478450|ensembl:ENSP00000482253|ensembl:ENST00000622216|ensembl:ENSP00000482044|ensembl:ENST00000622444|ensembl:ENSP00000482065|ensembl:ENST00000622600|ensembl:ENSP00000482727|ensembl:ENST00000622773|ensembl:ENSP00000484759|ensembl:ENST00000622864|ensembl:ENSP00000477726|ensembl:ENST00000339757|ensembl:ENSP00000344074|ensembl:ENST00000391721|ensembl:ENSP00000375601|ensembl:ENST00000427260|ensembl:ENSP00000402474|ensembl:ENSP00000409370|ensembl:ENST00000537859|ensembl:ENSP00000440601|ensembl:ENSP00000445135|ensembl:ENSP00000479220|ensembl:ENST00000611642|ensembl:ENSP00000484150|ensembl:ENST00000611676|ensembl:ENSP00000481999|ensembl:ENSP00000484354|ensembl:ENSP00000479109|ensembl:ENSP00000483281|ensembl:ENST00000613485|refseq:NP_001334932.1|dip:DIP-42460N	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	-	-	-	figure legend:3D|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:+AKz+b3v1+2sdqYqiEUVjyIpVrw9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:F04BA0E969F3B39F|rigid:6gjIFaDq0pPUF/JwqF67hs+wgzY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NX02	uniprotkb:Q56P42	intact:EBI-6374482|uniprotkb:Q8IXT0|uniprotkb:Q9BVN5|uniprotkb:Q9H6G6|uniprotkb:Q9HAV9|uniprotkb:Q9NWK3|uniprotkb:Q53FL5|uniprotkb:Q59G09|intact:EBI-28979473|ensembl:ENSP00000409370|ensembl:ENSP00000445135|ensembl:ENSP00000478265|ensembl:ENSP00000478450|ensembl:ENSP00000478774|ensembl:ENSP00000478876|ensembl:ENSP00000479109|ensembl:ENSP00000479220|ensembl:ENSP00000479352|ensembl:ENSP00000479713|ensembl:ENSP00000479783|ensembl:ENSP00000481851|ensembl:ENSP00000482253|ensembl:ENSP00000482889|ensembl:ENSP00000483281|ensembl:ENSP00000483528|ensembl:ENSP00000483963|ensembl:ENSP00000484354|uniprotkb:B4DZL7|uniprotkb:I3L0G4	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:nalp2_human(display_long)|uniprotkb:NLRP2(gene name)|psi-mi:NLRP2(display_short)|uniprotkb:NALP2(gene name synonym)|uniprotkb:NBS1(gene name synonym)|uniprotkb:PAN1(gene name synonym)|uniprotkb:PYPAF2(gene name synonym)|uniprotkb:Nucleotide-binding site protein 1(gene name synonym)|uniprotkb:PYRIN domain and NACHT domain-containing protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 2(gene name synonym)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001167552.1|refseq:NP_060322.1|refseq:NP_001167553.1|refseq:NP_001167554.1|ensembl:ENSG00000022556(gene)|ensembl:ENSG00000273992(gene)|ensembl:ENSG00000274638(gene)|ensembl:ENSG00000275082(gene)|ensembl:ENSG00000275399(gene)|ensembl:ENSG00000275796(gene)|ensembl:ENSG00000275843(gene)|ensembl:ENSG00000278682(gene)|ensembl:ENSG00000278789(gene)|ensembl:ENST00000448584(transcript)|ensembl:ENST00000543010(transcript)|ensembl:ENST00000611410(transcript)|ensembl:ENST00000611679(transcript)|ensembl:ENST00000611772(transcript)|ensembl:ENST00000613062(transcript)|ensembl:ENST00000613825(transcript)|ensembl:ENST00000615173(transcript)|ensembl:ENST00000615391(transcript)|ensembl:ENST00000615521(transcript)|ensembl:ENST00000616040(transcript)|ensembl:ENST00000619281(transcript)|ensembl:ENST00000619454(transcript)|ensembl:ENST00000619664(transcript)|ensembl:ENST00000621200(transcript)|ensembl:ENST00000621239(transcript)|ensembl:ENST00000621594(transcript)|ensembl:ENST00000622042(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9NX02|ensembl:ENSP00000483963|ensembl:ENSP00000484351|ensembl:ENST00000613851|ensembl:ENSP00000482628|ensembl:ENSP00000482889|ensembl:ENSP00000481851|ensembl:ENSP00000479352|ensembl:ENSP00000478876|ensembl:ENST00000616903|ensembl:ENSP00000482355|ensembl:ENST00000616919|ensembl:ENSP00000481564|ensembl:ENST00000618018|ensembl:ENSP00000483886|ensembl:ENST00000618694|ensembl:ENSP00000482465|ensembl:ENST00000618731|ensembl:ENSP00000478787|ensembl:ENST00000618789|ensembl:ENSP00000478318|ensembl:ENST00000618943|ensembl:ENSP00000482309|ensembl:ENSP00000478265|ensembl:ENSP00000483528|ensembl:ENSP00000478774|ensembl:ENST00000619885|ensembl:ENSP00000483389|ensembl:ENST00000621057|ensembl:ENSP00000484382|ensembl:ENSP00000479783|ensembl:ENSP00000479713|ensembl:ENSP00000478450|ensembl:ENSP00000482253|ensembl:ENST00000622216|ensembl:ENSP00000482044|ensembl:ENST00000622444|ensembl:ENSP00000482065|ensembl:ENST00000622600|ensembl:ENSP00000482727|ensembl:ENST00000622773|ensembl:ENSP00000484759|ensembl:ENST00000622864|ensembl:ENSP00000477726|ensembl:ENST00000339757|ensembl:ENSP00000344074|ensembl:ENST00000391721|ensembl:ENSP00000375601|ensembl:ENST00000427260|ensembl:ENSP00000402474|ensembl:ENSP00000409370|ensembl:ENST00000537859|ensembl:ENSP00000440601|ensembl:ENSP00000445135|ensembl:ENSP00000479220|ensembl:ENST00000611642|ensembl:ENSP00000484150|ensembl:ENST00000611676|ensembl:ENSP00000481999|ensembl:ENSP00000484354|ensembl:ENSP00000479109|ensembl:ENSP00000483281|ensembl:ENST00000613485|refseq:NP_001334932.1|dip:DIP-42460N	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	-	-	-	figure legend:3E|curation depth:mimix curation	taxid:9606(human-jurkat)|taxid:9606(Homo sapiens)	-	2012/10/23	2014/10/16	rogid:+AKz+b3v1+2sdqYqiEUVjyIpVrw9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:D98B147A51C35B17|rigid:6gjIFaDq0pPUF/JwqF67hs+wgzY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q56P42	uniprotkb:Q9NX02	intact:EBI-6374418|ensembl:ENSP00000492367	intact:EBI-6374482|uniprotkb:Q8IXT0|uniprotkb:Q9BVN5|uniprotkb:Q9H6G6|uniprotkb:Q9HAV9|uniprotkb:Q9NWK3|uniprotkb:Q53FL5|uniprotkb:Q59G09|intact:EBI-28979473|ensembl:ENSP00000409370|ensembl:ENSP00000445135|ensembl:ENSP00000478265|ensembl:ENSP00000478450|ensembl:ENSP00000478774|ensembl:ENSP00000478876|ensembl:ENSP00000479109|ensembl:ENSP00000479220|ensembl:ENSP00000479352|ensembl:ENSP00000479713|ensembl:ENSP00000479783|ensembl:ENSP00000481851|ensembl:ENSP00000482253|ensembl:ENSP00000482889|ensembl:ENSP00000483281|ensembl:ENSP00000483528|ensembl:ENSP00000483963|ensembl:ENSP00000484354|uniprotkb:B4DZL7|uniprotkb:I3L0G4	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:nalp2_human(display_long)|uniprotkb:NLRP2(gene name)|psi-mi:NLRP2(display_short)|uniprotkb:NALP2(gene name synonym)|uniprotkb:NBS1(gene name synonym)|uniprotkb:PAN1(gene name synonym)|uniprotkb:PYPAF2(gene name synonym)|uniprotkb:Nucleotide-binding site protein 1(gene name synonym)|uniprotkb:PYRIN domain and NACHT domain-containing protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	refseq:NP_001167552.1|refseq:NP_060322.1|refseq:NP_001167553.1|refseq:NP_001167554.1|ensembl:ENSG00000022556(gene)|ensembl:ENSG00000273992(gene)|ensembl:ENSG00000274638(gene)|ensembl:ENSG00000275082(gene)|ensembl:ENSG00000275399(gene)|ensembl:ENSG00000275796(gene)|ensembl:ENSG00000275843(gene)|ensembl:ENSG00000278682(gene)|ensembl:ENSG00000278789(gene)|ensembl:ENST00000448584(transcript)|ensembl:ENST00000543010(transcript)|ensembl:ENST00000611410(transcript)|ensembl:ENST00000611679(transcript)|ensembl:ENST00000611772(transcript)|ensembl:ENST00000613062(transcript)|ensembl:ENST00000613825(transcript)|ensembl:ENST00000615173(transcript)|ensembl:ENST00000615391(transcript)|ensembl:ENST00000615521(transcript)|ensembl:ENST00000616040(transcript)|ensembl:ENST00000619281(transcript)|ensembl:ENST00000619454(transcript)|ensembl:ENST00000619664(transcript)|ensembl:ENST00000621200(transcript)|ensembl:ENST00000621239(transcript)|ensembl:ENST00000621594(transcript)|ensembl:ENST00000622042(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9NX02|ensembl:ENSP00000483963|ensembl:ENSP00000484351|ensembl:ENST00000613851|ensembl:ENSP00000482628|ensembl:ENSP00000482889|ensembl:ENSP00000481851|ensembl:ENSP00000479352|ensembl:ENSP00000478876|ensembl:ENST00000616903|ensembl:ENSP00000482355|ensembl:ENST00000616919|ensembl:ENSP00000481564|ensembl:ENST00000618018|ensembl:ENSP00000483886|ensembl:ENST00000618694|ensembl:ENSP00000482465|ensembl:ENST00000618731|ensembl:ENSP00000478787|ensembl:ENST00000618789|ensembl:ENSP00000478318|ensembl:ENST00000618943|ensembl:ENSP00000482309|ensembl:ENSP00000478265|ensembl:ENSP00000483528|ensembl:ENSP00000478774|ensembl:ENST00000619885|ensembl:ENSP00000483389|ensembl:ENST00000621057|ensembl:ENSP00000484382|ensembl:ENSP00000479783|ensembl:ENSP00000479713|ensembl:ENSP00000478450|ensembl:ENSP00000482253|ensembl:ENST00000622216|ensembl:ENSP00000482044|ensembl:ENST00000622444|ensembl:ENSP00000482065|ensembl:ENST00000622600|ensembl:ENSP00000482727|ensembl:ENST00000622773|ensembl:ENSP00000484759|ensembl:ENST00000622864|ensembl:ENSP00000477726|ensembl:ENST00000339757|ensembl:ENSP00000344074|ensembl:ENST00000391721|ensembl:ENSP00000375601|ensembl:ENST00000427260|ensembl:ENSP00000402474|ensembl:ENSP00000409370|ensembl:ENST00000537859|ensembl:ENSP00000440601|ensembl:ENSP00000445135|ensembl:ENSP00000479220|ensembl:ENST00000611642|ensembl:ENSP00000484150|ensembl:ENST00000611676|ensembl:ENSP00000481999|ensembl:ENSP00000484354|ensembl:ENSP00000479109|ensembl:ENSP00000483281|ensembl:ENST00000613485|refseq:NP_001334932.1|dip:DIP-42460N	-	-	-	figure legend:3F|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/23	2014/10/16	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	rogid:+AKz+b3v1+2sdqYqiEUVjyIpVrw9606	intact-crc:4AE9347D66938D82|rigid:6gjIFaDq0pPUF/JwqF67hs+wgzY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q56P42	uniprotkb:P59046	intact:EBI-6374418|ensembl:ENSP00000492367	intact:EBI-6374637|ensembl:ENSP00000319377|uniprotkb:Q8NEU4|uniprotkb:Q9BY26|uniprotkb:A8MTQ2|uniprotkb:B3KTE7	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:nal12_human(display_long)|uniprotkb:NLRP12(gene name)|psi-mi:NLRP12(display_short)|uniprotkb:NALP12(gene name synonym)|uniprotkb:PYPAF7(gene name synonym)|uniprotkb:RNO(gene name synonym)|uniprotkb:Monarch-1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 7(gene name synonym)|uniprotkb:Regulated by nitric oxide(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374680	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	refseq:NP_001264055.1|ensembl:ENSG00000142405(gene)|ensembl:ENST00000324134(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032661"(regulation of interleukin-18 production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:2L6A|rcsb pdb:4XHS|rcsb pdb:5H7N|refseq:NP_653288.1|refseq:NP_001264058.1	-	-	-	figure legend:3F|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/23	2014/10/16	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	rogid:Xz+n9nKOs37FXy9nyLqwRLzNEps9606	intact-crc:3606A1698D76E968|rigid:IMWFS/oCTQkagjYKtL1KJxFHGtQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q56P42	uniprotkb:Q96MN2	intact:EBI-6374418|ensembl:ENSP00000492367	intact:EBI-6374609|uniprotkb:Q86W87|uniprotkb:Q96AY6|ensembl:ENSP00000301295	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:nalp4_human(display_long)|uniprotkb:NLRP4(gene name)|psi-mi:NLRP4(display_short)|uniprotkb:NALP4(gene name synonym)|uniprotkb:PAN2(gene name synonym)|uniprotkb:PYPAF4(gene name synonym)|uniprotkb:RNH2(gene name synonym)|uniprotkb:Cancer/testis antigen 58(gene name synonym)|uniprotkb:PAAD and NACHT-containing protein 2(gene name synonym)|uniprotkb:PYRIN and NACHT-containing protein 2(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 4(gene name synonym)|uniprotkb:Ribonuclease inhibitor 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374633	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	refseq:NP_604393.2|ensembl:ENSG00000160505(gene)|ensembl:ENST00000301295(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|rcsb pdb:4EWI|reactome:R-HSA-1606341|reactome:R-HSA-3134975|reactome:R-HSA-3270619|dip:DIP-60912N	-	-	-	figure legend:3F|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/23	2014/10/16	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	rogid:2J/LZ3I5M4XHeFOE9aLB0AO1Dmc9606	intact-crc:F17A4F34E63F30D7|rigid:UXE7TKGVPCZcQ/yip0Hk4Sk9JDE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ULZ3	uniprotkb:Q56P42	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	-	-	-	figure legend:3F|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/23	2014/10/16	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:BF8806B2220D5951|rigid:UP6conNrWlJuOey9XpMa5DEnMeA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C000	uniprotkb:Q56P42	intact:EBI-1220518|uniprotkb:Q9BZZ8|uniprotkb:Q9BZZ9|uniprotkb:Q9HAV8|uniprotkb:Q9UFT4|uniprotkb:Q9Y2E0|uniprotkb:E9PE50|uniprotkb:I6L9D9|uniprotkb:Q9H5Z7|uniprotkb:Q9H5Z8|ensembl:ENSP00000460475|ensembl:ENSP00000478516	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:nlrp1_human(display_long)|uniprotkb:NLRP1(gene name)|psi-mi:NLRP1(display_short)|uniprotkb:CARD7(gene name synonym)|uniprotkb:DEFCAP(gene name synonym)|uniprotkb:KIAA0926(gene name synonym)|uniprotkb:NAC(gene name synonym)|uniprotkb:NALP1(gene name synonym)|uniprotkb:Death effector filament-forming ced-4-like apoptosis protein(gene name synonym)|uniprotkb:Nucleotide-binding domain and caspase recruitment domain(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 7(gene name synonym)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028225.1|refseq:NP_055737.1|refseq:NP_127497.1|refseq:NP_127499.1|refseq:NP_127500.1|dip:DIP-38407N|ensembl:ENSG00000091592(gene)|ensembl:ENST00000572272(transcript)|ensembl:ENST00000617618(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043621"(protein self-association)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0006954"(inflammatory response)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070269"(pyroptosis)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0097264"(self proteolysis)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0140608"(cysteine-type endopeptidase activator activity)|go:"GO:1904784"(NLRP1 inflammasome complex assembly)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR025307|interpro:IPR027417|interpro:IPR032675|interpro:IPR033516|interpro:IPR041075|interpro:IPR041267|rcsb pdb:1PN5|rcsb pdb:3KAT|rcsb pdb:4IFP|rcsb pdb:4IM6|rcsb pdb:5Y3S|rcsb pdb:6K7V|rcsb pdb:6X6C|rcsb pdb:6XKK|reactome:R-HSA-844455	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	-	-	-	figure legend:3F|curation depth:mimix curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/23	2014/10/16	rogid:tlXizUa/MP9AnLH5RpYPMcCB3UY9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:190A7B607612BC3F|rigid:agYfBCtNqyUFzAfskBfQivZhrjQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WXC3	uniprotkb:Q9ULZ3	intact:EBI-6374437|uniprotkb:B2R8L4|uniprotkb:Q8NFP8|ensembl:ENSP00000304336	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	psi-mi:pydc1_human(display_long)|uniprotkb:PYDC1(gene name)|psi-mi:PYDC1(display_short)|uniprotkb:ASC2(gene name synonym)|uniprotkb:ASCI(gene name synonym)|uniprotkb:POP1(gene name synonym)|uniprotkb:PYC1(gene name synonym)|uniprotkb:PAAD-only protein 1(gene name synonym)|uniprotkb:Pyrin-only protein 1(gene name synonym)|uniprotkb:cellular POP1(gene name synonym)	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_690865.1|ensembl:ENSG00000169900(gene)|ensembl:ENST00000302964(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0045087"(innate immune response)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|rcsb pdb:2HM2|rcsb pdb:4QOB	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:4G|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:W3Zmdd03z5PKG2e0K9/a16kGd409606	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	intact-crc:AC445DC1EA5BC46A|rigid:1qVQZLtSGMa2fNuh5z0GTUfn+tc	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q56P42	uniprotkb:Q9NX02	intact:EBI-6374418|ensembl:ENSP00000492367	intact:EBI-6374482|uniprotkb:Q8IXT0|uniprotkb:Q9BVN5|uniprotkb:Q9H6G6|uniprotkb:Q9HAV9|uniprotkb:Q9NWK3|uniprotkb:Q53FL5|uniprotkb:Q59G09|intact:EBI-28979473|ensembl:ENSP00000409370|ensembl:ENSP00000445135|ensembl:ENSP00000478265|ensembl:ENSP00000478450|ensembl:ENSP00000478774|ensembl:ENSP00000478876|ensembl:ENSP00000479109|ensembl:ENSP00000479220|ensembl:ENSP00000479352|ensembl:ENSP00000479713|ensembl:ENSP00000479783|ensembl:ENSP00000481851|ensembl:ENSP00000482253|ensembl:ENSP00000482889|ensembl:ENSP00000483281|ensembl:ENSP00000483528|ensembl:ENSP00000483963|ensembl:ENSP00000484354|uniprotkb:B4DZL7|uniprotkb:I3L0G4	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:nalp2_human(display_long)|uniprotkb:NLRP2(gene name)|psi-mi:NLRP2(display_short)|uniprotkb:NALP2(gene name synonym)|uniprotkb:NBS1(gene name synonym)|uniprotkb:PAN1(gene name synonym)|uniprotkb:PYPAF2(gene name synonym)|uniprotkb:Nucleotide-binding site protein 1(gene name synonym)|uniprotkb:PYRIN domain and NACHT domain-containing protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374700	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	refseq:NP_001167552.1|refseq:NP_060322.1|refseq:NP_001167553.1|refseq:NP_001167554.1|ensembl:ENSG00000022556(gene)|ensembl:ENSG00000273992(gene)|ensembl:ENSG00000274638(gene)|ensembl:ENSG00000275082(gene)|ensembl:ENSG00000275399(gene)|ensembl:ENSG00000275796(gene)|ensembl:ENSG00000275843(gene)|ensembl:ENSG00000278682(gene)|ensembl:ENSG00000278789(gene)|ensembl:ENST00000448584(transcript)|ensembl:ENST00000543010(transcript)|ensembl:ENST00000611410(transcript)|ensembl:ENST00000611679(transcript)|ensembl:ENST00000611772(transcript)|ensembl:ENST00000613062(transcript)|ensembl:ENST00000613825(transcript)|ensembl:ENST00000615173(transcript)|ensembl:ENST00000615391(transcript)|ensembl:ENST00000615521(transcript)|ensembl:ENST00000616040(transcript)|ensembl:ENST00000619281(transcript)|ensembl:ENST00000619454(transcript)|ensembl:ENST00000619664(transcript)|ensembl:ENST00000621200(transcript)|ensembl:ENST00000621239(transcript)|ensembl:ENST00000621594(transcript)|ensembl:ENST00000622042(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|mint:Q9NX02|ensembl:ENSP00000483963|ensembl:ENSP00000484351|ensembl:ENST00000613851|ensembl:ENSP00000482628|ensembl:ENSP00000482889|ensembl:ENSP00000481851|ensembl:ENSP00000479352|ensembl:ENSP00000478876|ensembl:ENST00000616903|ensembl:ENSP00000482355|ensembl:ENST00000616919|ensembl:ENSP00000481564|ensembl:ENST00000618018|ensembl:ENSP00000483886|ensembl:ENST00000618694|ensembl:ENSP00000482465|ensembl:ENST00000618731|ensembl:ENSP00000478787|ensembl:ENST00000618789|ensembl:ENSP00000478318|ensembl:ENST00000618943|ensembl:ENSP00000482309|ensembl:ENSP00000478265|ensembl:ENSP00000483528|ensembl:ENSP00000478774|ensembl:ENST00000619885|ensembl:ENSP00000483389|ensembl:ENST00000621057|ensembl:ENSP00000484382|ensembl:ENSP00000479783|ensembl:ENSP00000479713|ensembl:ENSP00000478450|ensembl:ENSP00000482253|ensembl:ENST00000622216|ensembl:ENSP00000482044|ensembl:ENST00000622444|ensembl:ENSP00000482065|ensembl:ENST00000622600|ensembl:ENSP00000482727|ensembl:ENST00000622773|ensembl:ENSP00000484759|ensembl:ENST00000622864|ensembl:ENSP00000477726|ensembl:ENST00000339757|ensembl:ENSP00000344074|ensembl:ENST00000391721|ensembl:ENSP00000375601|ensembl:ENST00000427260|ensembl:ENSP00000402474|ensembl:ENSP00000409370|ensembl:ENST00000537859|ensembl:ENSP00000440601|ensembl:ENSP00000445135|ensembl:ENSP00000479220|ensembl:ENST00000611642|ensembl:ENSP00000484150|ensembl:ENST00000611676|ensembl:ENSP00000481999|ensembl:ENSP00000484354|ensembl:ENSP00000479109|ensembl:ENSP00000483281|ensembl:ENST00000613485|refseq:NP_001334932.1|dip:DIP-42460N	go:"GO:0031410"(cytoplasmic vesicle)	-	-	figure legend:4E|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	rogid:+AKz+b3v1+2sdqYqiEUVjyIpVrw9606	intact-crc:5FAD71A50D72BB03|rigid:6gjIFaDq0pPUF/JwqF67hs+wgzY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9ULZ3	uniprotkb:Q56P42	intact:EBI-751215|uniprotkb:Q96D12|uniprotkb:Q9BSZ5|uniprotkb:Q9HBD0|uniprotkb:Q9NXJ8|ensembl:ENSP00000247470	intact:EBI-6374418|ensembl:ENSP00000492367	psi-mi:asc_human(display_long)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)|uniprotkb:Target of methylation-induced silencing 1(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 5(gene name synonym)|uniprotkb:ASC(gene name synonym)|uniprotkb:CARD5(gene name synonym)|uniprotkb:TMS1(gene name synonym)|uniprotkb:PYCARD(gene name)|psi-mi:PYCARD(display_short)	psi-mi:pydc2_human(display_long)|uniprotkb:PYDC2(gene name)|psi-mi:PYDC2(display_short)|uniprotkb:POP2(gene name synonym)|uniprotkb:Pyrin-only protein 2(gene name synonym)|uniprotkb:cellular POP2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Dorfleutner et al. (2007)	pubmed:17178784	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6374695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_037390.2|refseq:NP_660183.1|dip:DIP-27618N|ensembl:ENSG00000103490(gene)|ensembl:ENST00000247470(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:1UCP|rcsb pdb:2KN6|rcsb pdb:3J63|rcsb pdb:5H8O|rcsb pdb:6K99|rcsb pdb:6KI0|rcsb pdb:6N1H|rcsb pdb:7KEU|reactome:R-HSA-5660668|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-9660826	refseq:NP_001076777.1|ensembl:ENSG00000253548(gene)|ensembl:ENST00000518817(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)	go:"GO:0031410"(cytoplasmic vesicle)	-	-	figure legend:4B|curation depth:mimix curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/23	2014/10/16	rogid:FfpNhWZB7QfBFjoYBFZwTNpxntw9606	rogid:4iPgGZ8XF40kbXMg1KBYWQYAnZ49606	intact-crc:6E82FF78F779326E|rigid:UP6conNrWlJuOey9XpMa5DEnMeA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)