#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9UMF0	uniprotkb:P05094	intact:EBI-6398041|ensembl:ENSP00000221980|uniprotkb:Q9Y6F3	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	psi-mi:icam5_human(display_long)|uniprotkb:ICAM5(gene name)|psi-mi:ICAM5(display_short)|uniprotkb:TLCN(gene name synonym)|uniprotkb:TLN(gene name synonym)|uniprotkb:Telencephalin(gene name synonym)	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nyman-Huttunen et al. (2006)	pubmed:16820411|imex:IM-18795	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6398017|imex:IM-18795-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011526531.1|ensembl:ENSG00000105376(gene)|ensembl:ENST00000221980(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BN3|rcsb pdb:4OI9|rcsb pdb:4OIA|rcsb pdb:4OIB|reactome:R-HSA-198933|reactome:R-HSA-216083|interpro:IPR036179|refseq:NP_003250.3	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	-	-	-	figure legend:"Fig 1B(b)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/26	2014/10/16	rogid:rL67QmGOsnIz99HXTOYoxzE1bWU9606	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	intact-crc:04730350162E2171|rigid:kCW2vxEE3+1aQI1qNARHfj/34kg	false	glutathione s tranferase tag:?-?|sufficient binding region:861-924	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05094	uniprotkb:Q9UMF0	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	intact:EBI-6398041|ensembl:ENSP00000221980|uniprotkb:Q9Y6F3	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:icam5_human(display_long)|uniprotkb:ICAM5(gene name)|psi-mi:ICAM5(display_short)|uniprotkb:TLCN(gene name synonym)|uniprotkb:TLN(gene name synonym)|uniprotkb:Telencephalin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nyman-Huttunen et al. (2006)	pubmed:16820411|imex:IM-18795	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6398069|imex:IM-18795-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	refseq:XP_011526531.1|ensembl:ENSG00000105376(gene)|ensembl:ENST00000221980(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BN3|rcsb pdb:4OI9|rcsb pdb:4OIA|rcsb pdb:4OIB|reactome:R-HSA-198933|reactome:R-HSA-216083|interpro:IPR036179|refseq:NP_003250.3	-	-	-	figure legend:"Fig 1C(a)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/11/26	2014/10/16	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	rogid:rL67QmGOsnIz99HXTOYoxzE1bWU9606	intact-crc:D19A3756CD09DDC4|rigid:kCW2vxEE3+1aQI1qNARHfj/34kg	false	-	mutation decreasing interaction:866-866|sufficient binding region:866-870|mutation decreasing interaction:867-867|mutation disrupting interaction:866-866,867-867|L-cysteine residue:c-c|mutation decreasing interaction:866-866|mutation disrupting interaction:867-867	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UMF0	uniprotkb:P05094	intact:EBI-6398041|ensembl:ENSP00000221980|uniprotkb:Q9Y6F3	intact:EBI-5847257|uniprotkb:Q99001|ensembl:ENSGALP00000064789	psi-mi:icam5_human(display_long)|uniprotkb:ICAM5(gene name)|psi-mi:ICAM5(display_short)|uniprotkb:TLCN(gene name synonym)|uniprotkb:TLN(gene name synonym)|uniprotkb:Telencephalin(gene name synonym)	psi-mi:actn1_chick(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nyman-Huttunen et al. (2006)	pubmed:16820411|imex:IM-18795	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6398102|imex:IM-18795-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011526531.1|ensembl:ENSG00000105376(gene)|ensembl:ENST00000221980(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR003988(Intercellular adhesion molecule)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BN3|rcsb pdb:4OI9|rcsb pdb:4OIA|rcsb pdb:4OIB|reactome:R-HSA-198933|reactome:R-HSA-216083|interpro:IPR036179|refseq:NP_003250.3	refseq:XP_015142744.1|refseq:NP_989458.1|ensembl:ENSGALG00000042458(gene)|ensembl:ENSGALT00000090288(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005915"(zonula adherens)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030486"(smooth muscle dense body)|go:"GO:0031252"(cell leading edge)|go:"GO:0042383"(sarcolemma)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:0097433"(dense body)|go:"GO:1990357"(terminal web)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|rcsb pdb:1SJJ|go:"GO:0001726"(ruffle)	-	-	-	figure legend:Fig 1E.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:22.9x10^-6(molar)	2012/11/26	2014/10/16	rogid:rL67QmGOsnIz99HXTOYoxzE1bWU9606	rogid:QTPHV4rf+9Jx+ry7IyUooDqGMU49031	intact-crc:EB2D5F6F084E292F|rigid:kCW2vxEE3+1aQI1qNARHfj/34kg	false	sufficient binding region:866-870|biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)