#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8WVC0 uniprotkb:Q9GZS3 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112206|imex:IM-20588-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:212EF01C0424466A|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8WVC0 uniprotkb:Q8N7H5 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112206|imex:IM-20588-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:212EF01C0424466A|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8WVC0 uniprotkb:Q6P1J9 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112206|imex:IM-20588-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:212EF01C0424466A|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8WVC0 uniprotkb:Q6PD62 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112206|imex:IM-20588-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:212EF01C0424466A|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8N7H5 uniprotkb:Q6P1J9 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112209|imex:IM-20588-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:0025C04B958BB241|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8N7H5 uniprotkb:Q6PD62 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112209|imex:IM-20588-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:0025C04B958BB241|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8N7H5 uniprotkb:Q8WVC0 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112209|imex:IM-20588-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:0025C04B958BB241|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8N7H5 uniprotkb:Q9GZS3 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112209|imex:IM-20588-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:0025C04B958BB241|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q8N7H5 uniprotkb:Q6PD62 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083407|imex:IM-20588-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:supplemental 3A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:16D21BC620E54B33|rigid:Rq8f7JvaP0PwEvXLYt+B6LfWqlY false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q8WVC0 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083407|imex:IM-20588-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:supplemental 3A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:16D21BC620E54B33|rigid:Rq8f7JvaP0PwEvXLYt+B6LfWqlY false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WVC0 uniprotkb:Q8N7H5 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083404|imex:IM-20588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:supplemental 3A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:F7A4F41284E04C6F|rigid:Rq8f7JvaP0PwEvXLYt+B6LfWqlY false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8WVC0 uniprotkb:Q6PD62 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083404|imex:IM-20588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:supplemental 3A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:F7A4F41284E04C6F|rigid:Rq8f7JvaP0PwEvXLYt+B6LfWqlY false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q6PD62 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083370|imex:IM-20588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1A and 1C|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:88BD65B0F96C5836|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8N7H5 uniprotkb:Q8WVC0 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083370|imex:IM-20588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1A and 1C|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:88BD65B0F96C5836|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8N7H5 uniprotkb:Q9GZS3 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083370|imex:IM-20588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:1A and 1C|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:88BD65B0F96C5836|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8N7H5 uniprotkb:Q6P1J9 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083370|imex:IM-20588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1A and 1C|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:88BD65B0F96C5836|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8WVC0 uniprotkb:Q9GZS3 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083389|imex:IM-20588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:7EDAF29BF3A38270|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8WVC0 uniprotkb:Q8N7H5 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083389|imex:IM-20588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:7EDAF29BF3A38270|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8WVC0 uniprotkb:Q6PD62 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083389|imex:IM-20588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:7EDAF29BF3A38270|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8WVC0 uniprotkb:Q6P1J9 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083389|imex:IM-20588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1A|comment:"Also detected (as probable contaminants): hsp70, tubulin, actin."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:7EDAF29BF3A38270|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9GZS3 uniprotkb:Q6P1J9 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083434|imex:IM-20588-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:BFE249549182684A|rigid:+xCxXL71eowe6rhfMt9h/tIXmRQ false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9GZS3 uniprotkb:Q15477 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 intact:EBI-373226|uniprotkb:O15005|uniprotkb:Q12902|uniprotkb:Q15476|intact:EBI-1058949|uniprotkb:Q5ST66|ensembl:ENSP00000364543|ensembl:ENSP00000372827|ensembl:ENSP00000394400|ensembl:ENSP00000399530|ensembl:ENSP00000400626|ensembl:ENSP00000412310 psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:skiv2_human(display_long)|uniprotkb:SKIV2L(gene name)|psi-mi:SKIV2L(display_short)|uniprotkb:DDX13(gene name synonym)|uniprotkb:SKI2W(gene name synonym)|uniprotkb:SKIV2(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:Helicase-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083434|imex:IM-20588-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N refseq:NP_008860.4|ensembl:ENSG00000204351(gene)|ensembl:ENSG00000206353(gene)|ensembl:ENSG00000223493(gene)|ensembl:ENSG00000225737(gene)|ensembl:ENSG00000228896(gene)|ensembl:ENSG00000232616(gene)|ensembl:ENST00000375394(transcript)|ensembl:ENST00000383336(transcript)|ensembl:ENST00000412823(transcript)|ensembl:ENST00000421789(transcript)|ensembl:ENST00000429465(transcript)|ensembl:ENST00000448219(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|mint:Q15477|reactome:R-HSA-390471|reactome:R-HSA-429958 - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 rogid:+42a3/XPqsM8hc3qP2M9n/pZ+bY9606 intact-crc:BFE249549182684A|rigid:+xCxXL71eowe6rhfMt9h/tIXmRQ false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9GZS3 uniprotkb:Q6PGP7 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 intact:EBI-6083436|uniprotkb:O15077|uniprotkb:Q6PJI3|ensembl:ENSP00000351596|ensembl:ENSP00000497948 psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:ttc37_human(display_long)|uniprotkb:Tricho-hepatic-enteric syndrome protein(gene name synonym)|uniprotkb:SKI3 homolog(gene name synonym)|uniprotkb:TTC37(gene name)|psi-mi:TTC37(display_short)|uniprotkb:KIAA0372(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083434|imex:IM-20588-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N refseq:NP_055454.1|ensembl:ENSG00000198677(gene)|ensembl:ENST00000358746(transcript)|ensembl:ENST00000649566(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0035327"|go:"GO:0055087"(Ski complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|mint:Q6PGP7|reactome:R-HSA-429958 - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 rogid:1vbt+NR8Vmwq7a+9fisoF2WxDbc9606 intact-crc:BFE249549182684A|rigid:+xCxXL71eowe6rhfMt9h/tIXmRQ false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9GZS3 uniprotkb:Q8N7H5 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083434|imex:IM-20588-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:BFE249549182684A|rigid:+xCxXL71eowe6rhfMt9h/tIXmRQ false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9GZS3 uniprotkb:Q8WVC0 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083434|imex:IM-20588-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:BFE249549182684A|rigid:+xCxXL71eowe6rhfMt9h/tIXmRQ false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9GZS3 uniprotkb:Q6PD62 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083434|imex:IM-20588-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:BFE249549182684A|rigid:+xCxXL71eowe6rhfMt9h/tIXmRQ false flag tag:?-? - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q6P1J9 uniprotkb:Q6PD62 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6083427|imex:IM-20588-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:1B and D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:68534E8A12EA98CA|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q6P1J9 uniprotkb:Q8WVC0 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6083427|imex:IM-20588-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:1B and D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:68534E8A12EA98CA|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q6P1J9 uniprotkb:Q8N7H5 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6083427|imex:IM-20588-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:1B and D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:68534E8A12EA98CA|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q6P1J9 uniprotkb:Q9GZS3 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6083427|imex:IM-20588-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:1B and D|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:68534E8A12EA98CA|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - flag tag:?-? - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q15477 uniprotkb:Q6PGP7 intact:EBI-373226|uniprotkb:O15005|uniprotkb:Q12902|uniprotkb:Q15476|intact:EBI-1058949|uniprotkb:Q5ST66|ensembl:ENSP00000364543|ensembl:ENSP00000372827|ensembl:ENSP00000394400|ensembl:ENSP00000399530|ensembl:ENSP00000400626|ensembl:ENSP00000412310 intact:EBI-6083436|uniprotkb:O15077|uniprotkb:Q6PJI3|ensembl:ENSP00000351596|ensembl:ENSP00000497948 psi-mi:skiv2_human(display_long)|uniprotkb:SKIV2L(gene name)|psi-mi:SKIV2L(display_short)|uniprotkb:DDX13(gene name synonym)|uniprotkb:SKI2W(gene name synonym)|uniprotkb:SKIV2(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:Helicase-like protein(gene name synonym) psi-mi:ttc37_human(display_long)|uniprotkb:Tricho-hepatic-enteric syndrome protein(gene name synonym)|uniprotkb:SKI3 homolog(gene name synonym)|uniprotkb:TTC37(gene name)|psi-mi:TTC37(display_short)|uniprotkb:KIAA0372(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6083460|imex:IM-20588-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008860.4|ensembl:ENSG00000204351(gene)|ensembl:ENSG00000206353(gene)|ensembl:ENSG00000223493(gene)|ensembl:ENSG00000225737(gene)|ensembl:ENSG00000228896(gene)|ensembl:ENSG00000232616(gene)|ensembl:ENST00000375394(transcript)|ensembl:ENST00000383336(transcript)|ensembl:ENST00000412823(transcript)|ensembl:ENST00000421789(transcript)|ensembl:ENST00000429465(transcript)|ensembl:ENST00000448219(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|mint:Q15477|reactome:R-HSA-390471|reactome:R-HSA-429958 refseq:NP_055454.1|ensembl:ENSG00000198677(gene)|ensembl:ENST00000358746(transcript)|ensembl:ENST00000649566(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0035327"|go:"GO:0055087"(Ski complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|mint:Q6PGP7|reactome:R-HSA-429958 - - - figure legend:1D and supplement 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:+42a3/XPqsM8hc3qP2M9n/pZ+bY9606 rogid:1vbt+NR8Vmwq7a+9fisoF2WxDbc9606 intact-crc:1A82873A3B430FB1|rigid:xyOGtKWUxfrQwEk9ahBHyx/9v8g false - - - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q15477 uniprotkb:Q9GZS3 intact:EBI-373226|uniprotkb:O15005|uniprotkb:Q12902|uniprotkb:Q15476|intact:EBI-1058949|uniprotkb:Q5ST66|ensembl:ENSP00000364543|ensembl:ENSP00000372827|ensembl:ENSP00000394400|ensembl:ENSP00000399530|ensembl:ENSP00000400626|ensembl:ENSP00000412310 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:skiv2_human(display_long)|uniprotkb:SKIV2L(gene name)|psi-mi:SKIV2L(display_short)|uniprotkb:DDX13(gene name synonym)|uniprotkb:SKI2W(gene name synonym)|uniprotkb:SKIV2(gene name synonym)|uniprotkb:W(gene name synonym)|uniprotkb:Helicase-like protein(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6083460|imex:IM-20588-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_008860.4|ensembl:ENSG00000204351(gene)|ensembl:ENSG00000206353(gene)|ensembl:ENSG00000223493(gene)|ensembl:ENSG00000225737(gene)|ensembl:ENSG00000228896(gene)|ensembl:ENSG00000232616(gene)|ensembl:ENST00000375394(transcript)|ensembl:ENST00000383336(transcript)|ensembl:ENST00000412823(transcript)|ensembl:ENST00000421789(transcript)|ensembl:ENST00000429465(transcript)|ensembl:ENST00000448219(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0055087"(Ski complex)|go:"GO:0070478"(nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012961(DSH, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016438(RNA helicase, ATP-dependent, SK12/DOB1)|interpro:IPR025696|interpro:IPR027417|interpro:IPR040801|mint:Q15477|reactome:R-HSA-390471|reactome:R-HSA-429958 refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:1D and supplement 3C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2012/04/11 2014/10/16 rogid:+42a3/XPqsM8hc3qP2M9n/pZ+bY9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:1A82873A3B430FB1|rigid:xyOGtKWUxfrQwEk9ahBHyx/9v8g false - flag tag:?-? - - psi-mi:"MI:0817"(molecular weight estimation by silver staining) psi-mi:"MI:0817"(molecular weight estimation by silver staining) uniprotkb:Q6PGP7 uniprotkb:Q8N7H5 intact:EBI-6083436|uniprotkb:O15077|uniprotkb:Q6PJI3|ensembl:ENSP00000351596|ensembl:ENSP00000497948 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:ttc37_human(display_long)|uniprotkb:Tricho-hepatic-enteric syndrome protein(gene name synonym)|uniprotkb:SKI3 homolog(gene name synonym)|uniprotkb:TTC37(gene name)|psi-mi:TTC37(display_short)|uniprotkb:KIAA0372(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083483|imex:IM-20588-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055454.1|ensembl:ENSG00000198677(gene)|ensembl:ENST00000358746(transcript)|ensembl:ENST00000649566(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0035327"|go:"GO:0055087"(Ski complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|mint:Q6PGP7|reactome:R-HSA-429958 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:1vbt+NR8Vmwq7a+9fisoF2WxDbc9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:1B77A7764A32AD7F|rigid:gJPm+ieMBEWyUTm4qz7wC+QCkug false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q6PD62 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083501|imex:IM-20588-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:Supplement. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:E712275E46D71CD1|rigid:Rq8f7JvaP0PwEvXLYt+B6LfWqlY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q8WVC0 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083501|imex:IM-20588-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:E712275E46D71CD1|rigid:Rq8f7JvaP0PwEvXLYt+B6LfWqlY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24928 uniprotkb:Q6PD62 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083520|imex:IM-20588-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:4F0C46F25D71EEC8|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24928 uniprotkb:Q6P1J9 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083520|imex:IM-20588-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:4F0C46F25D71EEC8|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24928 uniprotkb:Q8N7H5 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083520|imex:IM-20588-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:4F0C46F25D71EEC8|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24928 uniprotkb:Q92541 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083520|imex:IM-20588-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 intact-crc:4F0C46F25D71EEC8|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P24928 uniprotkb:Q8WVC0 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083520|imex:IM-20588-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:4F0C46F25D71EEC8|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q6PD62 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083506|imex:IM-20588-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:64F3448289BF14B3|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q92541 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083506|imex:IM-20588-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 intact-crc:64F3448289BF14B3|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q8WVC0 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083506|imex:IM-20588-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:64F3448289BF14B3|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:P24928 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083506|imex:IM-20588-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 intact-crc:64F3448289BF14B3|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q6P1J9 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083506|imex:IM-20588-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:64F3448289BF14B3|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92541 uniprotkb:Q8N7H5 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112184|imex:IM-20588-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 intact-crc:6D4A2ED76681B95F|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92541 uniprotkb:P24928 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 intact:EBI-295301|uniprotkb:A6NN93|uniprotkb:B9EH88|uniprotkb:Q6NX41|intact:EBI-17957133|intact:EBI-14758660|intact:EBI-13324911|intact:EBI-23311874 psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:rpb1_human(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:POLR2(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112184|imex:IM-20588-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_000928.1|mint:P24928|dip:DIP-29011N|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|rcsb pdb:2GHQ|rcsb pdb:2GHT|rcsb pdb:2LTO|rcsb pdb:3D9K|rcsb pdb:3D9L|rcsb pdb:3D9M|rcsb pdb:3D9N|rcsb pdb:3D9O|rcsb pdb:3D9P|rcsb pdb:4JXT|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5M3H|rcsb pdb:5M3J|rcsb pdb:6DRD|rcsb pdb:6F5P|rcsb pdb:6G0R|rcsb pdb:6IC8|rcsb pdb:6IC9|rcsb pdb:6O9L|rcsb pdb:6Q5Y|rcsb pdb:6XKB|rcsb pdb:6XRE|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606 intact-crc:6D4A2ED76681B95F|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92541 uniprotkb:Q6P1J9 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112184|imex:IM-20588-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:6D4A2ED76681B95F|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92541 uniprotkb:Q8WVC0 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112184|imex:IM-20588-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:6D4A2ED76681B95F|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92541 uniprotkb:Q6PD62 intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6112184|imex:IM-20588-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:Supplement. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:6D4A2ED76681B95F|rigid:0C1cZpskfwC3fwvxRY5Caep5d3M false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q6PGP7 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-6083436|uniprotkb:O15077|uniprotkb:Q6PJI3|ensembl:ENSP00000351596|ensembl:ENSP00000497948 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ttc37_human(display_long)|uniprotkb:Tricho-hepatic-enteric syndrome protein(gene name synonym)|uniprotkb:SKI3 homolog(gene name synonym)|uniprotkb:TTC37(gene name)|psi-mi:TTC37(display_short)|uniprotkb:KIAA0372(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083472|imex:IM-20588-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055454.1|ensembl:ENSG00000198677(gene)|ensembl:ENST00000358746(transcript)|ensembl:ENST00000649566(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0035327"|go:"GO:0055087"(Ski complex)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039226|mint:Q6PGP7|reactome:R-HSA-429958 - - - figure legend:1E|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:1vbt+NR8Vmwq7a+9fisoF2WxDbc9606 intact-crc:B78C78F337E41E7F|rigid:gJPm+ieMBEWyUTm4qz7wC+QCkug false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N7H5 uniprotkb:Q6PD62 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083494|imex:IM-20588-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N - - - figure legend:Supplemental 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606 intact-crc:4787924E7A2CF627|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8N7H5 uniprotkb:Q6P1J9 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083494|imex:IM-20588-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplemental 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606 intact-crc:4787924E7A2CF627|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8N7H5 uniprotkb:Q9GZS3 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083494|imex:IM-20588-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N - - - figure legend:Supplemental 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606 intact-crc:4787924E7A2CF627|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8N7H5 uniprotkb:Q8WVC0 intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35 intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601 psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym) psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Zhu et al. (2005) pubmed:16024656|imex:IM-20588 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6083494|imex:IM-20588-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654 - - - figure legend:Supplemental 1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2012/04/11 2014/10/16 rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606 rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606 intact-crc:4787924E7A2CF627|rigid:hXXhlT4Lb3VAQl1O/QlawlROfSE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0082"(peptide massfingerprinting)