#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O02697 uniprotkb:Q3U6Q4 intact:EBI-6172289 intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522 psi-mi:pk3cg_pig(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:p120-PI3K(gene name synonym) psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Suire et al. (2005) pubmed:15797027|imex:IM-17395 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6172287|imex:IM-17395-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001525"(angiogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0002376"(immune system process)|refseq:NP_999104.1|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR018936|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|rcsb pdb:1E7U|rcsb pdb:1E7V|rcsb pdb:1E8W|rcsb pdb:1E8X|rcsb pdb:1E90|interpro:IPR029071|interpro:IPR042236|interpro:IPR035892|interpro:IPR036940 refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2012/07/03 2014/10/16 rogid:jHERY6q/KGwGDMXjKzwZ103djm89823 rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090 intact-crc:D0E6B3E151456306|rigid:PDWTwD7/M/WZ1BW5J2lzNKqW13Q false myc tag:?-? glu tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O02697 uniprotkb:O02696 intact:EBI-6172289 intact:EBI-6172343 psi-mi:pk3cg_pig(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:p120-PI3K(gene name synonym) psi-mi:pi3r5_pig(display_long)|uniprotkb:PIK3R5(gene name)|psi-mi:PIK3R5(display_short)|uniprotkb:IB PI3-kinase p101 subunit(gene name synonym)|uniprotkb:PI3-kinase p101 subunit(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit(gene name synonym)|uniprotkb:PtdIns-3-kinase p101(gene name synonym)|uniprotkb:p101-PI3K(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Suire et al. (2005) pubmed:15797027|imex:IM-17395 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6172341|imex:IM-17395-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001525"(angiogenesis)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0002376"(immune system process)|refseq:NP_999104.1|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR018936|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|rcsb pdb:1E7U|rcsb pdb:1E7V|rcsb pdb:1E8W|rcsb pdb:1E8X|rcsb pdb:1E90|interpro:IPR029071|interpro:IPR042236|interpro:IPR035892|interpro:IPR036940 go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|interpro:IPR019522|refseq:NP_999016.1 - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2012/07/03 2014/10/16 rogid:jHERY6q/KGwGDMXjKzwZ103djm89823 rogid:KMhWhnb2VztN9ZNOg/YLN1FGcRQ9823 intact-crc:94236E7D7D85146A|rigid:3yogREq/qlkkz31/2XFwkSox1w8 false myc tag:?-? glu tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3U6Q4 uniprotkb:Q5SW28 intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522 intact:EBI-4303969|uniprotkb:Q3TU01|uniprotkb:Q3UDZ2|uniprotkb:Q8C215|uniprotkb:Q8CGQ7|ensembl:ENSMUSP00000021283 psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym) psi-mi:pi3r5_mouse(display_long)|uniprotkb:Pik3r5(gene name)|psi-mi:Pik3r5(display_short)|uniprotkb:PI3-kinase p101 subunit(gene name synonym)|uniprotkb:PtdIns-3-kinase p101(gene name synonym)|uniprotkb:p101-PI3K(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Suire et al. (2005) pubmed:15797027|imex:IM-17395 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6247988|imex:IM-17395-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N refseq:NP_796294.2|refseq:XP_006533611.1|reactome:R-MMU-392451|reactome:R-MMU-9027276|ensembl:ENSMUSG00000020901(gene)|ensembl:ENSMUST00000021283(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499 - - - figure legend:4B|comment:Interaction is disrupted in p110gamma/Pik3cg -/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neutrophil)|taxid:10090(Mus musculus neutrophil) - 2012/07/03 2014/10/16 rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090 rogid:zQMWsyVX4qcX4jkZoQPnlsmJgJA10090 intact-crc:4CA5EAA447107E02|rigid:qlqUC+Wb00yyHQeT9sUfXolFufY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q3U6Q4 uniprotkb:Q9JHG7 intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522 intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400 psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym) psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Suire et al. (2005) pubmed:15797027|imex:IM-17395 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6247988|imex:IM-17395-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N - - - figure legend:4B|comment:Interaction is disrupted in p110gamma/Pik3cg -/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neutrophil)|taxid:10090(Mus musculus neutrophil) - 2012/07/03 2014/10/16 rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090 rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090 intact-crc:4CA5EAA447107E02|rigid:qlqUC+Wb00yyHQeT9sUfXolFufY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5SW28 uniprotkb:Q3U6Q4 intact:EBI-4303969|uniprotkb:Q3TU01|uniprotkb:Q3UDZ2|uniprotkb:Q8C215|uniprotkb:Q8CGQ7|ensembl:ENSMUSP00000021283 intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522 psi-mi:pi3r5_mouse(display_long)|uniprotkb:Pik3r5(gene name)|psi-mi:Pik3r5(display_short)|uniprotkb:PI3-kinase p101 subunit(gene name synonym)|uniprotkb:PtdIns-3-kinase p101(gene name synonym)|uniprotkb:p101-PI3K(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit(gene name synonym) psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Suire et al. (2005) pubmed:15797027|imex:IM-17395 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6247993|imex:IM-17395-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_796294.2|refseq:XP_006533611.1|reactome:R-MMU-392451|reactome:R-MMU-9027276|ensembl:ENSMUSG00000020901(gene)|ensembl:ENSMUST00000021283(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499 refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neutrophil)|taxid:10090(Mus musculus neutrophil) - 2012/07/03 2014/10/16 rogid:zQMWsyVX4qcX4jkZoQPnlsmJgJA10090 rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090 intact-crc:30E24032031E9B21|rigid:qlqUC+Wb00yyHQeT9sUfXolFufY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5SW28 uniprotkb:Q9JHG7 intact:EBI-4303969|uniprotkb:Q3TU01|uniprotkb:Q3UDZ2|uniprotkb:Q8C215|uniprotkb:Q8CGQ7|ensembl:ENSMUSP00000021283 intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400 psi-mi:pi3r5_mouse(display_long)|uniprotkb:Pik3r5(gene name)|psi-mi:Pik3r5(display_short)|uniprotkb:PI3-kinase p101 subunit(gene name synonym)|uniprotkb:PtdIns-3-kinase p101(gene name synonym)|uniprotkb:p101-PI3K(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase regulatory subunit(gene name synonym) psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Suire et al. (2005) pubmed:15797027|imex:IM-17395 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-6247993|imex:IM-17395-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_796294.2|refseq:XP_006533611.1|reactome:R-MMU-392451|reactome:R-MMU-9027276|ensembl:ENSMUSG00000020901(gene)|ensembl:ENSMUST00000021283(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499 refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N - - - figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-neutrophil)|taxid:10090(Mus musculus neutrophil) - 2012/07/03 2014/10/16 rogid:zQMWsyVX4qcX4jkZoQPnlsmJgJA10090 rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090 intact-crc:30E24032031E9B21|rigid:qlqUC+Wb00yyHQeT9sUfXolFufY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)