#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y3E5	uniprotkb:Q08117	intact:EBI-1056751|uniprotkb:Q9NTE5|uniprotkb:B3KUY4|ensembl:ENSP00000376758|ensembl:ENSP00000464327	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:pth2_human(display_long)|uniprotkb:PTRH2(gene name)|psi-mi:PTRH2(display_short)|uniprotkb:BIT1(gene name synonym)|uniprotkb:PTH2(gene name synonym)|uniprotkb:CGI-147(orf name)|uniprotkb:Bcl-2 inhibitor of transcription 1(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jan et al. (2004)	imex:IM-17910|pubmed:15006356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6373920|imex:IM-17910-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057161.1|refseq:NP_001015509.1|refseq:XP_011523189.1|ensembl:ENSG00000141378(gene)|ensembl:ENST00000393038(transcript)|ensembl:ENST00000470557(transcript)|go:"GO:0004045"(aminoacyl-tRNA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:2000210"(positive regulation of anoikis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002833(Peptidyl-tRNA hydrolase, PTH2)|interpro:IPR023476|mint:Q9Y3E5|rcsb pdb:1Q7S|reactome:R-HSA-5689880	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	-	-	-	figure legend:text|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/10/19	2014/10/16	rogid:E0QOhTNtGBt5CQ3gPebnOhoKvdU9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	intact-crc:18F0E0A40FEF9C7A|rigid:G9u9oIFcmxR7XG7YmnLMKBYw8Kw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Y3E5	uniprotkb:Q08117	intact:EBI-1056751|uniprotkb:Q9NTE5|uniprotkb:B3KUY4|ensembl:ENSP00000376758|ensembl:ENSP00000464327	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:pth2_human(display_long)|uniprotkb:PTRH2(gene name)|psi-mi:PTRH2(display_short)|uniprotkb:BIT1(gene name synonym)|uniprotkb:PTH2(gene name synonym)|uniprotkb:CGI-147(orf name)|uniprotkb:Bcl-2 inhibitor of transcription 1(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jan et al. (2004)	imex:IM-17910|pubmed:15006356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6374065|imex:IM-17910-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057161.1|refseq:NP_001015509.1|refseq:XP_011523189.1|ensembl:ENSG00000141378(gene)|ensembl:ENST00000393038(transcript)|ensembl:ENST00000470557(transcript)|go:"GO:0004045"(aminoacyl-tRNA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:2000210"(positive regulation of anoikis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002833(Peptidyl-tRNA hydrolase, PTH2)|interpro:IPR023476|mint:Q9Y3E5|rcsb pdb:1Q7S|reactome:R-HSA-5689880	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	go:"GO:0005829"(cytosol)	-	-	figure legend:5c|agonist:"Bit1 (ptrh2) must bear an N-terminal tag, so the protein will localize in the cytosol and the intraction can happen."|antagonist:Co-expression with TLE1 decreases the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/10/19	2014/10/16	rogid:E0QOhTNtGBt5CQ3gPebnOhoKvdU9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	intact-crc:00F247DA41ED4EE1|rigid:G9u9oIFcmxR7XG7YmnLMKBYw8Kw	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y3E5	uniprotkb:Q08117	intact:EBI-1056751|uniprotkb:Q9NTE5|uniprotkb:B3KUY4|ensembl:ENSP00000376758|ensembl:ENSP00000464327	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:pth2_human(display_long)|uniprotkb:PTRH2(gene name)|psi-mi:PTRH2(display_short)|uniprotkb:BIT1(gene name synonym)|uniprotkb:PTH2(gene name synonym)|uniprotkb:CGI-147(orf name)|uniprotkb:Bcl-2 inhibitor of transcription 1(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jan et al. (2004)	imex:IM-17910|pubmed:15006356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6373935|imex:IM-17910-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057161.1|refseq:NP_001015509.1|refseq:XP_011523189.1|ensembl:ENSG00000141378(gene)|ensembl:ENST00000393038(transcript)|ensembl:ENST00000470557(transcript)|go:"GO:0004045"(aminoacyl-tRNA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:2000210"(positive regulation of anoikis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002833(Peptidyl-tRNA hydrolase, PTH2)|interpro:IPR023476|mint:Q9Y3E5|rcsb pdb:1Q7S|reactome:R-HSA-5689880	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	go:"GO:0005829"(cytosol)	-	-	figure legend:3a|agonist:"Bit1 (ptrh2) must bear an N-terminal tag, so the protein will localize in the cytosol and the interaction can happen."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/10/19	2014/10/16	rogid:E0QOhTNtGBt5CQ3gPebnOhoKvdU9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	intact-crc:7A487F151D2957E6|rigid:G9u9oIFcmxR7XG7YmnLMKBYw8Kw	false	flag tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Y3E5	uniprotkb:Q08117	intact:EBI-1056751|uniprotkb:Q9NTE5|uniprotkb:B3KUY4|ensembl:ENSP00000376758|ensembl:ENSP00000464327	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	psi-mi:pth2_human(display_long)|uniprotkb:PTRH2(gene name)|psi-mi:PTRH2(display_short)|uniprotkb:BIT1(gene name synonym)|uniprotkb:PTH2(gene name synonym)|uniprotkb:CGI-147(orf name)|uniprotkb:Bcl-2 inhibitor of transcription 1(gene name synonym)	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jan et al. (2004)	imex:IM-17910|pubmed:15006356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6374034|imex:IM-17910-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057161.1|refseq:NP_001015509.1|refseq:XP_011523189.1|ensembl:ENSG00000141378(gene)|ensembl:ENST00000393038(transcript)|ensembl:ENST00000470557(transcript)|go:"GO:0004045"(aminoacyl-tRNA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:2000210"(positive regulation of anoikis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002833(Peptidyl-tRNA hydrolase, PTH2)|interpro:IPR023476|mint:Q9Y3E5|rcsb pdb:1Q7S|reactome:R-HSA-5689880	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	go:"GO:0005829"(cytosol)	-	-	figure legend:3c|agonist:"Cells must undergo programmed cell death indicued by detachment (anoikis) for ptrh2 to be released into the cytosol and the interaction to take place."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/10/19	2014/10/16	rogid:E0QOhTNtGBt5CQ3gPebnOhoKvdU9606	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	intact-crc:6176FCD3ACA8DEC1|rigid:G9u9oIFcmxR7XG7YmnLMKBYw8Kw	false	myc tag:c-c	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08117	uniprotkb:Q9Y3E5	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	intact:EBI-1056751|uniprotkb:Q9NTE5|uniprotkb:B3KUY4|ensembl:ENSP00000376758|ensembl:ENSP00000464327	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:pth2_human(display_long)|uniprotkb:PTRH2(gene name)|psi-mi:PTRH2(display_short)|uniprotkb:BIT1(gene name synonym)|uniprotkb:PTH2(gene name synonym)|uniprotkb:CGI-147(orf name)|uniprotkb:Bcl-2 inhibitor of transcription 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jan et al. (2004)	imex:IM-17910|pubmed:15006356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6374008|imex:IM-17910-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	refseq:NP_057161.1|refseq:NP_001015509.1|refseq:XP_011523189.1|ensembl:ENSG00000141378(gene)|ensembl:ENST00000393038(transcript)|ensembl:ENST00000470557(transcript)|go:"GO:0004045"(aminoacyl-tRNA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:2000210"(positive regulation of anoikis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002833(Peptidyl-tRNA hydrolase, PTH2)|interpro:IPR023476|mint:Q9Y3E5|rcsb pdb:1Q7S|reactome:R-HSA-5689880	go:"GO:0005829"(cytosol)	-	-	figure legend:3a and 5d|agonist:"Bit1 (ptrh2) must bear an N-terminal tag, so the protein will localize in the cytosol and the intraction can happen."|antagonist:Culturing the cells with fibronectin decreases detachment and reduces the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/10/19	2014/10/16	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	rogid:E0QOhTNtGBt5CQ3gPebnOhoKvdU9606	intact-crc:8007487FDB224644|rigid:G9u9oIFcmxR7XG7YmnLMKBYw8Kw	false	flag tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q08117	uniprotkb:Q9Y3E5	intact:EBI-717810|uniprotkb:Q12808|uniprotkb:Q96TG9|uniprotkb:Q9UDY9|uniprotkb:B2RBL0|uniprotkb:Q14CJ1|ensembl:ENSP00000317537	intact:EBI-1056751|uniprotkb:Q9NTE5|uniprotkb:B3KUY4|ensembl:ENSP00000376758|ensembl:ENSP00000464327	psi-mi:tle5_human(display_long)|uniprotkb:TLE5(gene name)|psi-mi:TLE5(display_short)|uniprotkb:AES(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:GRG(gene name synonym)|uniprotkb:GRG5(gene name synonym)|uniprotkb:Gp130-associated protein GAM(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)|uniprotkb:TLE family member 5, transcriptional modulator(gene name synonym)	psi-mi:pth2_human(display_long)|uniprotkb:PTRH2(gene name)|psi-mi:PTRH2(display_short)|uniprotkb:BIT1(gene name synonym)|uniprotkb:PTH2(gene name synonym)|uniprotkb:CGI-147(orf name)|uniprotkb:Bcl-2 inhibitor of transcription 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Jan et al. (2004)	imex:IM-17910|pubmed:15006356	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6374029|imex:IM-17910-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121.2|refseq:NP_945320.1|refseq:NP_945321.1|ensembl:ENSG00000104964(gene)|ensembl:ENST00000327141(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:Q08117|reactome:R-HSA-4641265|go:"GO:0032091"(negative regulation of protein binding)	refseq:NP_057161.1|refseq:NP_001015509.1|refseq:XP_011523189.1|ensembl:ENSG00000141378(gene)|ensembl:ENST00000393038(transcript)|ensembl:ENST00000470557(transcript)|go:"GO:0004045"(aminoacyl-tRNA hydrolase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:2000210"(positive regulation of anoikis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002833(Peptidyl-tRNA hydrolase, PTH2)|interpro:IPR023476|mint:Q9Y3E5|rcsb pdb:1Q7S|reactome:R-HSA-5689880	-	-	-	figure legend:3b|agonist:"Interaction happens in the event of programmed cell death due to cell detachment (anoikis)."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2012/10/19	2014/10/16	rogid:eveYX2Rj6Oz431E8nGcTk4bUNt89606	rogid:E0QOhTNtGBt5CQ3gPebnOhoKvdU9606	intact-crc:8F4EC77BB1FE8814|rigid:G9u9oIFcmxR7XG7YmnLMKBYw8Kw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)