#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P98082	uniprotkb:Q96B97	intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307824|imex:IM-17876-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/09/27	2014/10/16	rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:8EFD6EDCA12B1902|rigid:1txK+QxrV6t7kRYJJrIc09jJFlw	false	-	sufficient binding region:1-328	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P98082	uniprotkb:Q96B97	intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307813|imex:IM-17876-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/09/27	2014/10/16	rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:6F6F8A52D3A56585|rigid:1txK+QxrV6t7kRYJJrIc09jJFlw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97318	uniprotkb:Q96B97	intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307839|imex:IM-17876-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:00A841EB87969FBD|rigid:tfbBDaWrL7Clm5VAh2wwP+X1mw0	false	ha tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-328	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98078	uniprotkb:Q96B97	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307835|imex:IM-17876-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:1B and C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:D4F30F7E3E84FD60|rigid:QlUjQoQ3kc1ZrN34F4mTCRyDjzU	false	flag tag:?-?	glutathione s tranferase tag:?-?|sufficient binding region:1-99|sufficient binding region:59-271|sufficient binding region:158-328	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P98078	uniprotkb:Q96B97	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6308042|imex:IM-17876-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:4D|antagonist:"c-Cb1 peptide SQVPERPPKFPRRINSE (corresponds to human CBL UniProt P22681  aa 817-834). A mutant peptide with arg829ala does not change the  interaction."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:2CCAA0ED40DA3CDE|rigid:QlUjQoQ3kc1ZrN34F4mTCRyDjzU	false	flag tag:?-?	sufficient binding region:59-271|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96B97	uniprotkb:P98078	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307900|imex:IM-17876-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:3A|antagonist:EGF stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	intact-crc:00E5E3BC0C4DCCF1|rigid:YaATgMkxqK8yqb/9AWzIkJj3aHw	false	glutathione s tranferase tag:?-?|necessary binding region:1-328	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B97	uniprotkb:Q68FD5	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-769168|ensembl:ENSMUSP00000099475	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:clh1_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307900|imex:IM-17876-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	refseq:NP_001003908.1|dip:DIP-31947N|ensembl:ENSMUSG00000047126(gene)|ensembl:ENSMUST00000103186(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030315"(T-tubule)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042277"(peptide binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043209"(myelin sheath)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q68FD5|rcsb pdb:5ODS|reactome:R-MMU-177504|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-5099900|reactome:R-MMU-5140745|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866427|reactome:R-MMU-8964038|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0032051"(clathrin light chain binding)	-	-	-	figure legend:3A|antagonist:EGF stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:iHg/TOG2rWePqtsEmuc/szn/chI10090	intact-crc:00E5E3BC0C4DCCF1|rigid:YaATgMkxqK8yqb/9AWzIkJj3aHw	false	glutathione s tranferase tag:?-?|necessary binding region:1-328	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B97	uniprotkb:P98078	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307905|imex:IM-17876-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	intact-crc:3EE5F5E441BE5B81|rigid:ABvIYz1S6gibTIvpSm5XNzjnRqY	false	glutathione s tranferase tag:?-?|sufficient binding region:1-328	mutation decreasing interaction:718-718	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B97	uniprotkb:Q00610	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-354967|intact:EBI-28974011|ensembl:ENSP00000269122|uniprotkb:Q6N0A0|uniprotkb:Q86TF2|uniprotkb:D3DU00	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:clh1_human(display_long)|uniprotkb:Clathrin heavy chain on chromosome 17(gene name synonym)|uniprotkb:CLTC(gene name)|psi-mi:CLTC(display_short)|uniprotkb:CLH17(gene name synonym)|uniprotkb:KIAA0034(gene name synonym)|uniprotkb:CLTCL2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307905|imex:IM-17876-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	ensembl:ENSG00000141367(gene)|ensembl:ENST00000269122(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0031623"(receptor internalization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033572"(transferrin transport)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042470"(melanosome)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|refseq:NP_004850.1|ensembl:ENSP00000269122|ensembl:ENST00000393043|ensembl:ENSP00000376763|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015348(Clathrin, heavy chain, linker, core motif)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016025(Clathrin, heavy chain, linker and propeller)|interpro:IPR016341(Clathrin, heavy chain)|interpro:IPR022365|mint:Q00610|rcsb pdb:2XZG|rcsb pdb:4G55|rcsb pdb:6E4L|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-3928665|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9013420|reactome:R-HSA-9013424	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:oGsLXL5J5MHO+ronpDIG9hJ11sU9606	intact-crc:3EE5F5E441BE5B81|rigid:ABvIYz1S6gibTIvpSm5XNzjnRqY	false	glutathione s tranferase tag:?-?|sufficient binding region:1-328	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98078	uniprotkb:Q96B97	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307878|imex:IM-17876-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:B95661F17F9406F9|rigid:QlUjQoQ3kc1ZrN34F4mTCRyDjzU	false	mutation disrupting interaction:718-718	sufficient binding region:1-328|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98078	uniprotkb:Q96B97	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307893|imex:IM-17876-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:2C and 4A/C|antagonist:EGF stimulation|antagonist:"c-Cb1 peptide SQVPERPPKFPRRINSE (corresponds to human CBL UniProt P22681 aa 817-834)."|comment:Binding between CIN85 and Dab2 was observed in unstimulated cells, was significantly decreased after 2 min of EGF stimulation, and completely undetectable after 20 min.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:52676D55F842691C|rigid:QlUjQoQ3kc1ZrN34F4mTCRyDjzU	false	mutation decreasing interaction:718-718|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B97	uniprotkb:P98078	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6308059|imex:IM-17876-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:4E|antagonist:EGF stimulation|antagonist:"c-Cb1 peptide SQVPERPPKFPRRINSE (corresponds to human CBL UniProt P22681 aa 817-834). A mutant peptide with arg829ala does not change the interaction."|comment:EGF stimulation reduces assocation of DAB2 and has no effect on association of CBL. Transfecting CBL with a arg829ala mutation impairs association of CBL and enhances association of DAB2, irrespectively of EGF stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	intact-crc:6FF6554BED8CA189|rigid:OvLkoiQikVF7lpnqG8Udxff1F8M	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B97	uniprotkb:P22681	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6308059|imex:IM-17876-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:4E|antagonist:EGF stimulation|antagonist:"c-Cb1 peptide SQVPERPPKFPRRINSE (corresponds to human CBL UniProt P22681 aa 817-834). A mutant peptide with arg829ala does not change the interaction."|comment:EGF stimulation reduces assocation of DAB2 and has no effect on association of CBL. Transfecting CBL with a arg829ala mutation impairs association of CBL and enhances association of DAB2, irrespectively of EGF stimulation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:6FF6554BED8CA189|rigid:OvLkoiQikVF7lpnqG8Udxff1F8M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98078	uniprotkb:Q96B97	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6308003|imex:IM-17876-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:2C and 4A|antagonist:EGF stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:0D24FFE7E1857EE5|rigid:QlUjQoQ3kc1ZrN34F4mTCRyDjzU	false	flag tag:?-?|mutation disrupting interaction:718-718	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98078	uniprotkb:Q8R550	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6308023|imex:IM-17876-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	-	-	-	figure legend:4B|antagonist:EGF stimulation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_saa)|taxid:10090(Mus musculus NIH SAA cells)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	intact-crc:026F11F7D505A82A|rigid:p1jYh7RrbvW2K9I2r7fRFUSxumY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B97	uniprotkb:P22681	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	intact:EBI-518228|uniprotkb:A3KMP8|ensembl:ENSP00000264033	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:cbl_human(display_long)|uniprotkb:Signal transduction protein CBL(gene name synonym)|uniprotkb:Proto-oncogene c-Cbl(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene(gene name synonym)|uniprotkb:RING finger protein 55(gene name synonym)|uniprotkb:CBL(gene name)|psi-mi:CBL(display_short)|uniprotkb:CBL2(gene name synonym)|uniprotkb:RNF55(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CBL(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307872|imex:IM-17876-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	refseq:NP_005179.2|ensembl:ENSP00000264033|dip:DIP-189N|ensembl:ENSG00000110395(gene)|ensembl:ENST00000264033(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005929"(cilium)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008584"(male gonad development)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016600"(flotillin complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0033574"(response to testosterone)|go:"GO:0035635"(entry of bacterium into host cell)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042594"(response to starvation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070997"(neuron death)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR009060(UBA-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:P22681|rcsb pdb:1B47|rcsb pdb:1FBV|rcsb pdb:1YVH|rcsb pdb:2CBL|rcsb pdb:2JUJ|rcsb pdb:2K4D|rcsb pdb:2OO9|rcsb pdb:2Y1M|rcsb pdb:2Y1N|rcsb pdb:3BUM|rcsb pdb:3BUN|rcsb pdb:3BUO|rcsb pdb:3BUW|rcsb pdb:3BUX|rcsb pdb:3OB1|rcsb pdb:3OB2|rcsb pdb:3PLF|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4GPL|rcsb pdb:5HKW|rcsb pdb:5HKX|rcsb pdb:5HKY|rcsb pdb:5HKZ|rcsb pdb:5HL0|rcsb pdb:5J3X|rcsb pdb:5O76|rcsb pdb:6O02|rcsb pdb:6O03|rcsb pdb:6XAR|reactome:R-HSA-1059683|reactome:R-HSA-1236382|reactome:R-HSA-1295596|reactome:R-HSA-1433559|reactome:R-HSA-182971|reactome:R-HSA-2173789|reactome:R-HSA-5637810|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-6807004|reactome:R-HSA-8849469|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-912631|reactome:R-HSA-9706369|reactome:R-HSA-9706377	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	rogid:WPXFRmBKHEANKUlN/OYsuyAe9a09606	intact-crc:82F99CADA23559D9|rigid:GLBFKno880+VSvGXyk/Jo+adX0g	false	-	sufficient binding region:817-834	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P98078	uniprotkb:Q96B97	intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1	intact:EBI-346595|uniprotkb:Q8IWX6|uniprotkb:Q8IX98|uniprotkb:Q96RN4|uniprotkb:Q9NYR0|uniprotkb:B7Z1D5|uniprotkb:Q5JPT4|uniprotkb:Q5JPT5|ensembl:ENSP00000380921	psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)	psi-mi:sh3k1_human(display_long)|uniprotkb:SH3KBP1(gene name)|psi-mi:SH3KBP1(display_short)|uniprotkb:CIN85(gene name synonym)|uniprotkb:Cbl-interacting protein of 85 kDa(gene name synonym)|uniprotkb:Human Src family kinase-binding protein 1(gene name synonym)|uniprotkb:CD2-binding protein 3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Kowanetz et al. (2003)	pubmed:14596919|imex:IM-17876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6307868|imex:IM-17876-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001019837.1|refseq:NP_114098.1|refseq:NP_001171889.1|refseq:XP_016884958.1|dip:DIP-31803N|ensembl:ENSG00000147010(gene)|ensembl:ENST00000397821(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q96B97|rcsb pdb:2BZ8|rcsb pdb:2K6D|rcsb pdb:2K9G|rcsb pdb:2N64|rcsb pdb:2O2O|rcsb pdb:2YDL|rcsb pdb:5ABS|reactome:R-HSA-182971|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866376|reactome:R-HSA-8875360|reactome:R-HSA-983695|go:"GO:0007015"(actin filament organization)	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/27	2014/10/16	rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090	rogid:WB37Fbtwe/IA57zPOHhbmdNNI1s9606	intact-crc:B6FDC2CCBEBDA943|rigid:QlUjQoQ3kc1ZrN34F4mTCRyDjzU	false	sufficient binding region:707-724	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)