#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03968	uniprotkb:P03969	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-6357665|ensembl:ENSBTAP00000007477	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:fgf2_bovin(display_long)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6357804|imex:IM-17912-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|go:"GO:0045766"(positive regulation of angiogenesis)|ensembl:ENSBTAG00000005691(gene)|ensembl:ENSBTAT00000007477(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)	-	-	-	figure legend:Table 1, Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:+Ss7qvCYvB4tzfN3pQEH1RB1QM89913	intact-crc:E147C5D075F91751|rigid:05Tsv8DaQ4BAUy+ugNK51pX4T8c	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03968	uniprotkb:P03969	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-6357665|ensembl:ENSBTAP00000007477	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:fgf2_bovin(display_long)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6357804|imex:IM-17912-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|go:"GO:0045766"(positive regulation of angiogenesis)|ensembl:ENSBTAG00000005691(gene)|ensembl:ENSBTAT00000007477(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)	-	-	-	figure legend:Table 1, Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:+Ss7qvCYvB4tzfN3pQEH1RB1QM89913	intact-crc:E147C5D075F91751|rigid:05Tsv8DaQ4BAUy+ugNK51pX4T8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03968	uniprotkb:P21802	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-1028658|uniprotkb:P18443|uniprotkb:Q01742|uniprotkb:Q12922|uniprotkb:Q14300|uniprotkb:Q14301|uniprotkb:Q14302|uniprotkb:Q14303|uniprotkb:Q14304|uniprotkb:Q14305|uniprotkb:Q14672|uniprotkb:Q14718|uniprotkb:Q14719|uniprotkb:Q86YI4|uniprotkb:Q96KL9|uniprotkb:Q96KM0|uniprotkb:Q96KM1|uniprotkb:Q96KM2|uniprotkb:Q9NZU2|uniprotkb:Q9NZU3|uniprotkb:Q9UD01|uniprotkb:Q9UD02|uniprotkb:Q9UIH3|uniprotkb:Q9UIH4|uniprotkb:Q9UIH5|uniprotkb:Q9UIH6|uniprotkb:Q9UIH7|uniprotkb:Q9UIH8|uniprotkb:Q9UM87|uniprotkb:Q9UMC6|uniprotkb:Q9UNS7|uniprotkb:Q9UQH7|uniprotkb:Q9UQH8|uniprotkb:Q9UQH9|uniprotkb:Q9UQI0|uniprotkb:Q1KHY5|ensembl:ENSP00000351276|uniprotkb:B4DFC2|uniprotkb:E7EVR6|uniprotkb:E9PCR0|uniprotkb:Q8IXC7	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:fgfr2_human(display_long)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:K-sam(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6357804|imex:IM-17912-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	refseq:NP_000132.3|refseq:NP_001138385.1|refseq:NP_001138386.1|refseq:NP_001138387.1|refseq:NP_001138388.1|refseq:NP_001138389.1|refseq:NP_001138390.1|refseq:NP_001138391.1|refseq:NP_075259.4|ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007409"(axonogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030901"(midbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0035265"(organ growth)|go:"GO:0035602"(fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell)|go:"GO:0035603"(fibroblast growth factor receptor signaling pathway involved in hemopoiesis)|go:"GO:0035604"(fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060174"(limb bud formation)|go:"GO:0060348"(bone development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060512"(prostate gland morphogenesis)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060529"(squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)|go:"GO:0060595"(fibroblast growth factor receptor signaling pathway involved in mammary gland specification)|go:"GO:0060601"(lateral sprouting from an epithelium)|go:"GO:0060615"(mammary gland bud formation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060667"(branch elongation involved in salivary gland morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060688"(regulation of morphogenesis of a branching structure)|go:"GO:0060915"(mesenchymal cell differentiation involved in lung development)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|mint:P21802|rcsb pdb:1DJS|rcsb pdb:1E0O|rcsb pdb:1EV2|rcsb pdb:1GJO|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:1NUN|rcsb pdb:1OEC|rcsb pdb:1WVZ|rcsb pdb:2FDB|rcsb pdb:2PSQ|rcsb pdb:2PVF|rcsb pdb:2PVY|rcsb pdb:2PWL|rcsb pdb:2PY3|rcsb pdb:2PZ5|rcsb pdb:2PZP|rcsb pdb:2PZR|rcsb pdb:2Q0B|rcsb pdb:3B2T|rcsb pdb:3CAF|rcsb pdb:3CLY|rcsb pdb:3CU1|rcsb pdb:3DAR|rcsb pdb:3EUU|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3RI1|rcsb pdb:4J23|rcsb pdb:4J95|rcsb pdb:4J96|rcsb pdb:4J97|rcsb pdb:4J98|rcsb pdb:4J99|rcsb pdb:4WV1|rcsb pdb:5EG3|rcsb pdb:5UGL|rcsb pdb:5UGX|rcsb pdb:5UHN|rcsb pdb:5UI0|rcsb pdb:6AGX|rcsb pdb:6LVK|rcsb pdb:6LVL|rcsb pdb:6V6Q|rcsb pdb:7KIA|rcsb pdb:7KIE|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190375|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853333|reactome:R-HSA-190377|reactome:R-HSA-2023837|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|refseq:NP_001307583.1|refseq:NP_001307587.1|refseq:NP_075418.1|dip:DIP-3788N	-	-	-	figure legend:Table 1, Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	intact-crc:E147C5D075F91751|rigid:05Tsv8DaQ4BAUy+ugNK51pX4T8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21802	uniprotkb:P03968	intact:EBI-1028658|uniprotkb:P18443|uniprotkb:Q01742|uniprotkb:Q12922|uniprotkb:Q14300|uniprotkb:Q14301|uniprotkb:Q14302|uniprotkb:Q14303|uniprotkb:Q14304|uniprotkb:Q14305|uniprotkb:Q14672|uniprotkb:Q14718|uniprotkb:Q14719|uniprotkb:Q86YI4|uniprotkb:Q96KL9|uniprotkb:Q96KM0|uniprotkb:Q96KM1|uniprotkb:Q96KM2|uniprotkb:Q9NZU2|uniprotkb:Q9NZU3|uniprotkb:Q9UD01|uniprotkb:Q9UD02|uniprotkb:Q9UIH3|uniprotkb:Q9UIH4|uniprotkb:Q9UIH5|uniprotkb:Q9UIH6|uniprotkb:Q9UIH7|uniprotkb:Q9UIH8|uniprotkb:Q9UM87|uniprotkb:Q9UMC6|uniprotkb:Q9UNS7|uniprotkb:Q9UQH7|uniprotkb:Q9UQH8|uniprotkb:Q9UQH9|uniprotkb:Q9UQI0|uniprotkb:Q1KHY5|ensembl:ENSP00000351276|uniprotkb:B4DFC2|uniprotkb:E7EVR6|uniprotkb:E9PCR0|uniprotkb:Q8IXC7	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	psi-mi:fgfr2_human(display_long)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:K-sam(gene name synonym)	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6358088|imex:IM-17912-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000132.3|refseq:NP_001138385.1|refseq:NP_001138386.1|refseq:NP_001138387.1|refseq:NP_001138388.1|refseq:NP_001138389.1|refseq:NP_001138390.1|refseq:NP_001138391.1|refseq:NP_075259.4|ensembl:ENSG00000066468(gene)|ensembl:ENST00000358487(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0005007"(fibroblast growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007409"(axonogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008589"(regulation of smoothened signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0021847"(ventricular zone neuroblast division)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030901"(midbrain development)|go:"GO:0030916"(otic vesicle formation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032808"(lacrimal gland development)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0035265"(organ growth)|go:"GO:0035602"(fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell)|go:"GO:0035603"(fibroblast growth factor receptor signaling pathway involved in hemopoiesis)|go:"GO:0035604"(fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow)|go:"GO:0035607"(fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development)|go:"GO:0042060"(wound healing)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045471"(response to ethanol)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048562"(embryonic organ morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048755"(branching morphogenesis of a nerve)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060174"(limb bud formation)|go:"GO:0060348"(bone development)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060512"(prostate gland morphogenesis)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060529"(squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)|go:"GO:0060595"(fibroblast growth factor receptor signaling pathway involved in mammary gland specification)|go:"GO:0060601"(lateral sprouting from an epithelium)|go:"GO:0060615"(mammary gland bud formation)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060667"(branch elongation involved in salivary gland morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060688"(regulation of morphogenesis of a branching structure)|go:"GO:0060915"(mesenchymal cell differentiation involved in lung development)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016248(Fibroblast growth factor receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041159|mint:P21802|rcsb pdb:1DJS|rcsb pdb:1E0O|rcsb pdb:1EV2|rcsb pdb:1GJO|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:1NUN|rcsb pdb:1OEC|rcsb pdb:1WVZ|rcsb pdb:2FDB|rcsb pdb:2PSQ|rcsb pdb:2PVF|rcsb pdb:2PVY|rcsb pdb:2PWL|rcsb pdb:2PY3|rcsb pdb:2PZ5|rcsb pdb:2PZP|rcsb pdb:2PZR|rcsb pdb:2Q0B|rcsb pdb:3B2T|rcsb pdb:3CAF|rcsb pdb:3CLY|rcsb pdb:3CU1|rcsb pdb:3DAR|rcsb pdb:3EUU|rcsb pdb:3OJ2|rcsb pdb:3OJM|rcsb pdb:3RI1|rcsb pdb:4J23|rcsb pdb:4J95|rcsb pdb:4J96|rcsb pdb:4J97|rcsb pdb:4J98|rcsb pdb:4J99|rcsb pdb:4WV1|rcsb pdb:5EG3|rcsb pdb:5UGL|rcsb pdb:5UGX|rcsb pdb:5UHN|rcsb pdb:5UI0|rcsb pdb:6AGX|rcsb pdb:6LVK|rcsb pdb:6LVL|rcsb pdb:6V6Q|rcsb pdb:7KIA|rcsb pdb:7KIE|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190375|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853333|reactome:R-HSA-190377|reactome:R-HSA-2023837|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|refseq:NP_001307583.1|refseq:NP_001307587.1|refseq:NP_075418.1|dip:DIP-3788N	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	-	-	-	figure legend:Table 1, Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:XW6x8AHgdb29IL3MhUFWpv4jaqE9606	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	intact-crc:ED8776596AA14C46|rigid:7Favu+cofQAvaCQCdkQEI1y+fLA	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21802-3	uniprotkb:P03968	intact:EBI-6354683|ensembl:ENSP00000410294	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	psi-mi:p21802-3(display_long)|uniprotkb:BFR-1(isoform synonym)|uniprotkb:FGFR2IIIb(isoform synonym)|uniprotkb:KGFR(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6358174|imex:IM-17912-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1028658(isoform-parent)|ensembl:ENSG00000066468(gene)|ensembl:ENST00000457416(transcript)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	-	-	-	figure legend:Table 1, Figure 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:Q8fYzApSVJb08my/HcpLIsdcmmg9606	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	intact-crc:233D9C8C77AD109E|rigid:zbRzfYlDmeGlqHGmYacrYFQzB7Y	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03968	uniprotkb:P03969	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-6357665|ensembl:ENSBTAP00000007477	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:fgf2_bovin(display_long)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6354659|imex:IM-17912-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|go:"GO:0045766"(positive regulation of angiogenesis)|ensembl:ENSBTAG00000005691(gene)|ensembl:ENSBTAT00000007477(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)	-	-	-	figure legend:Table 1, Figure 2|comment:b-FGF was a poor competitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:+Ss7qvCYvB4tzfN3pQEH1RB1QM89913	intact-crc:DA690E70BAB8CED4|rigid:Rk+5X5pdj5jndT8u2mbitekgnBk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03968	uniprotkb:P21781	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-3937699|ensembl:ENSP00000267843|uniprotkb:H0YNY5|uniprotkb:Q6FGV5|uniprotkb:Q96FG5	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:fgf7_human(display_long)|uniprotkb:FGF7(gene name)|psi-mi:FGF7(display_short)|uniprotkb:KGF(gene name synonym)|uniprotkb:Heparin-binding growth factor 7(gene name synonym)|uniprotkb:Keratinocyte growth factor(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6354659|imex:IM-17912-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	ensembl:ENSG00000140285(gene)|ensembl:ENST00000267843(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005111"(type 2 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028247|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190377|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|refseq:NP_002000.1|dip:DIP-4010N	-	-	-	figure legend:Table 1, Figure 2|comment:b-FGF was a poor competitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:/3ZlUGYt/GG5qHPcr+ZxKg7N6dk9606	intact-crc:DA690E70BAB8CED4|rigid:Rk+5X5pdj5jndT8u2mbitekgnBk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03968	uniprotkb:P21781	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-3937699|ensembl:ENSP00000267843|uniprotkb:H0YNY5|uniprotkb:Q6FGV5|uniprotkb:Q96FG5	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:fgf7_human(display_long)|uniprotkb:FGF7(gene name)|psi-mi:FGF7(display_short)|uniprotkb:KGF(gene name synonym)|uniprotkb:Heparin-binding growth factor 7(gene name synonym)|uniprotkb:Keratinocyte growth factor(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6354659|imex:IM-17912-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	ensembl:ENSG00000140285(gene)|ensembl:ENST00000267843(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005111"(type 2 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028247|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190377|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|refseq:NP_002000.1|dip:DIP-4010N	-	-	-	figure legend:Table 1, Figure 2|comment:b-FGF was a poor competitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:/3ZlUGYt/GG5qHPcr+ZxKg7N6dk9606	intact-crc:DA690E70BAB8CED4|rigid:Rk+5X5pdj5jndT8u2mbitekgnBk	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03968	uniprotkb:P21802-3	intact:EBI-6358090|uniprotkb:Q3ZBL8|ensembl:ENSBTAP00000040651|ensembl:ENSBTAP00000058186|ensembl:ENSBTAP00000065580|ensembl:ENSBTAP00000073018	intact:EBI-6354683|ensembl:ENSP00000410294	psi-mi:fgf1_bovin(display_long)|uniprotkb:FGF1(gene name)|psi-mi:FGF1(display_short)|uniprotkb:AFGF(gene name synonym)|uniprotkb:FGFA(gene name synonym)|uniprotkb:HBGF-1(gene name synonym)|uniprotkb:Acidic eye-derived growth factor II(gene name synonym)|uniprotkb:Acidic fibroblast growth factor(gene name synonym)|uniprotkb:Endothelial cell growth factor(gene name synonym)|uniprotkb:Heparin-binding growth factor 1(gene name synonym)|uniprotkb:Prostatropin(gene name synonym)	psi-mi:p21802-3(display_long)|uniprotkb:BFR-1(isoform synonym)|uniprotkb:FGFR2IIIb(isoform synonym)|uniprotkb:KGFR(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6354659|imex:IM-17912-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776480.1|ensembl:ENSBTAG00000005198(gene)|ensembl:ENSBTAT00000043056(transcript)|ensembl:ENSBTAT00000068787(transcript)|ensembl:ENSBTAT00000072959(transcript)|ensembl:ENSBTAT00000078959(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060681"(branch elongation involved in ureteric bud branching)|go:"GO:0072163"(mesonephric epithelium development)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028210|rcsb pdb:1AFC|rcsb pdb:1BAR|reactome:R-BTA-109704|reactome:R-BTA-1257604|reactome:R-BTA-190322|reactome:R-BTA-190370|reactome:R-BTA-190371|reactome:R-BTA-190372|reactome:R-BTA-190373|reactome:R-BTA-190375|reactome:R-BTA-190377|reactome:R-BTA-5654219|reactome:R-BTA-5654221|reactome:R-BTA-5654227|reactome:R-BTA-5654228|reactome:R-BTA-5654687|reactome:R-BTA-5654688|reactome:R-BTA-5654689|reactome:R-BTA-5654693|reactome:R-BTA-5654695|reactome:R-BTA-5654699|reactome:R-BTA-5654700|reactome:R-BTA-5654704|reactome:R-BTA-5654706|reactome:R-BTA-5654710|reactome:R-BTA-5654712|reactome:R-BTA-5654719|reactome:R-BTA-5654720|reactome:R-BTA-5654726|reactome:R-BTA-5654727|reactome:R-BTA-5654732|reactome:R-BTA-5654733|reactome:R-BTA-5673001|reactome:R-BTA-6811558|refseq:NP_001300935.1|refseq:XP_015327761.1|refseq:XP_015327762.1|refseq:XP_015327763.1	intact:EBI-1028658(isoform-parent)|ensembl:ENSG00000066468(gene)|ensembl:ENST00000457416(transcript)	-	-	-	figure legend:Table 1, Figure 2|comment:b-FGF was a poor competitor|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:/cYt3aRwt8fGg53QyXuy1BI2IKM9913	rogid:Q8fYzApSVJb08my/HcpLIsdcmmg9606	intact-crc:DA690E70BAB8CED4|rigid:Rk+5X5pdj5jndT8u2mbitekgnBk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21802-3	uniprotkb:P21781	intact:EBI-6354683|ensembl:ENSP00000410294	intact:EBI-3937699|ensembl:ENSP00000267843|uniprotkb:H0YNY5|uniprotkb:Q6FGV5|uniprotkb:Q96FG5	psi-mi:p21802-3(display_long)|uniprotkb:BFR-1(isoform synonym)|uniprotkb:FGFR2IIIb(isoform synonym)|uniprotkb:KGFR(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)	psi-mi:fgf7_human(display_long)|uniprotkb:FGF7(gene name)|psi-mi:FGF7(display_short)|uniprotkb:KGF(gene name synonym)|uniprotkb:Heparin-binding growth factor 7(gene name synonym)|uniprotkb:Keratinocyte growth factor(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6359440|imex:IM-17912-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-1028658(isoform-parent)|ensembl:ENSG00000066468(gene)|ensembl:ENST00000457416(transcript)	ensembl:ENSG00000140285(gene)|ensembl:ENST00000267843(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005111"(type 2 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028247|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190377|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|refseq:NP_002000.1|dip:DIP-4010N	-	-	-	figure legend:3A|comment:The presence/absence of the first IgG loop had little effect on KGF binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/10/15	2014/10/16	rogid:Q8fYzApSVJb08my/HcpLIsdcmmg9606	rogid:/3ZlUGYt/GG5qHPcr+ZxKg7N6dk9606	intact-crc:35238982351EBB86|rigid:boKd5HgnaznTToyoiAu2Po0Qbzc	false	-	125i radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P21781	uniprotkb:P21802-3	intact:EBI-3937699|ensembl:ENSP00000267843|uniprotkb:H0YNY5|uniprotkb:Q6FGV5|uniprotkb:Q96FG5	intact:EBI-6354683|ensembl:ENSP00000410294	psi-mi:fgf7_human(display_long)|uniprotkb:FGF7(gene name)|psi-mi:FGF7(display_short)|uniprotkb:KGF(gene name synonym)|uniprotkb:Heparin-binding growth factor 7(gene name synonym)|uniprotkb:Keratinocyte growth factor(gene name synonym)	psi-mi:p21802-3(display_long)|uniprotkb:BFR-1(isoform synonym)|uniprotkb:FGFR2IIIb(isoform synonym)|uniprotkb:KGFR(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Miki et al. (1992)	pubmed:1309608|imex:IM-17912	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6359708|imex:IM-17912-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000140285(gene)|ensembl:ENST00000267843(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005111"(type 2 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008544"(epidermis development)|go:"GO:0009611"(response to wounding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060445"(branching involved in salivary gland morphogenesis)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0061033"(secretion by lung epithelial cell involved in lung growth)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028247|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-190377|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-5654221|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654727|reactome:R-HSA-5655253|reactome:R-HSA-5673001|reactome:R-HSA-6811558|refseq:NP_002000.1|dip:DIP-4010N	intact:EBI-1028658(isoform-parent)|ensembl:ENSG00000066468(gene)|ensembl:ENST00000457416(transcript)	-	-	-	figure legend:3B|comment:The presence/absence of the first IgG loop had little effect on KGF binding.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:200.0x10^-12(molar)	2012/10/15	2014/10/16	rogid:/3ZlUGYt/GG5qHPcr+ZxKg7N6dk9606	rogid:Q8fYzApSVJb08my/HcpLIsdcmmg9606	intact-crc:2F5054A95B4CC5AC|rigid:boKd5HgnaznTToyoiAu2Po0Qbzc	false	125i radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)