#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:G3I8R9 uniprotkb:G3IL63 intact:EBI-988311|intact:EBI-1557723 intact:EBI-6429131 psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:g3il63_crigr(display_long)|uniprotkb:I79_024625(orf name) psi-mi:"MI:0663"(confocal microscopy) Reddy et al. (2003) imex:IM-18510|pubmed:12665508 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-6429199|imex:IM-18510-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007507"(heart development)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR033139|refseq:XP_003515232.1|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR015471(Caspase-7) go:"GO:0005641"(nuclear envelope lumen) - - figure legend:1c|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho-c1)|taxid:10029(GRP78 overexpressing, DHFR-deficient CHO cells) - 2012/12/05 2014/10/16 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 rogid:7lsoV+oROe3rU+TtM4WsazQHAbM10029 intact-crc:DD3290F4F505FC09|rigid:IMcg5f9ioB5I5JKm2EI40zkveAs false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:G3IL63 uniprotkb:G3I8R9 intact:EBI-6429131 intact:EBI-988311|intact:EBI-1557723 psi-mi:g3il63_crigr(display_long)|uniprotkb:I79_024625(orf name) psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Reddy et al. (2003) imex:IM-18510|pubmed:12665508 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6449162|imex:IM-18510-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007507"(heart development)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR033139|refseq:XP_003515232.1|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR015471(Caspase-7) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 - - - figure legend:6a and 6b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2012/12/05 2014/10/16 rogid:7lsoV+oROe3rU+TtM4WsazQHAbM10029 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 intact-crc:0E724AC1C8990C3B|rigid:IMcg5f9ioB5I5JKm2EI40zkveAs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3I8R9 uniprotkb:G3IL63 intact:EBI-988311|intact:EBI-1557723 intact:EBI-6429131 psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name) psi-mi:g3il63_crigr(display_long)|uniprotkb:I79_024625(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Reddy et al. (2003) imex:IM-18510|pubmed:12665508 taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6429241|imex:IM-18510-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129 interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007507"(heart development)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR033139|refseq:XP_003515232.1|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR015471(Caspase-7) - - - figure legend:6a and 6b|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho-c1)|taxid:10029(GRP78 overexpressing, DHFR-deficient CHO cells) - 2012/12/05 2014/10/16 rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029 rogid:7lsoV+oROe3rU+TtM4WsazQHAbM10029 intact-crc:B0FCC7D9F1682B16|rigid:IMcg5f9ioB5I5JKm2EI40zkveAs false necessary binding region:176-200 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)