#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P33535	uniprotkb:P70498	intact:EBI-4392569|uniprotkb:Q62846|uniprotkb:Q64064|uniprotkb:Q64120|uniprotkb:Q2TV20|uniprotkb:Q2TV21|uniprotkb:Q4VWM5|uniprotkb:Q4VWM7|uniprotkb:Q4VWX7|uniprotkb:Q4VWX8|ensembl:ENSRNOP00000074079	intact:EBI-6140589|uniprotkb:O08768	psi-mi:oprm_rat(display_long)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Ror-b(gene name synonym)|uniprotkb:Opioid receptor B(gene name synonym)	psi-mi:pld2_rat(display_long)|uniprotkb:Pld2(gene name)|psi-mi:Pld2(display_short)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Koch et al. (2003)	pubmed:12519790|imex:IM-20550	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6140587|imex:IM-20550-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291664.1|refseq:NP_001291666.1|refseq:NP_001291667.1|refseq:NP_001291669.1|rgd:3234|refseq:NP_001033686.1|refseq:NP_001033689.1|refseq:NP_001033690.1|refseq:NP_037203.1|ensembl:ENSRNOG00000018191|refseq:NP_001033688.2|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009314"(response to radiation)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0030425"(dendrite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-111885|reactome:R-RNO-202040|reactome:R-RNO-375276|reactome:R-RNO-418594|ensembl:ENSRNOG00000018191(gene)|ensembl:ENSRNOT00000083308(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)	interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR036871|mint:P70498|rgd:3350|refseq:NP_150641.2|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001683(Phox-like)|interpro:IPR025202|interpro:IPR001849(Pleckstrin-like)|interpro:IPR015679(Phospholipase D)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031526"(brush border membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|reactome:R-RNO-1483166|reactome:R-RNO-2029485|reactome:R-RNO-9013149|reactome:R-RNO-9013404	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/05/31	2014/10/16	rogid:wNrY62jBw3FWtANSbP1ygSZuFc410116	rogid:lHss1RrhpH2K9x19XTxxQoqTYG410116	intact-crc:F57E87EFBB69BA6A|rigid:8bjnrA4HrpX1gr2RpmtCPQ+yxlk	false	sufficient binding region:340-398	sufficient binding region:116-226	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P33535	uniprotkb:P70498	intact:EBI-4392569|uniprotkb:Q62846|uniprotkb:Q64064|uniprotkb:Q64120|uniprotkb:Q2TV20|uniprotkb:Q2TV21|uniprotkb:Q4VWM5|uniprotkb:Q4VWM7|uniprotkb:Q4VWX7|uniprotkb:Q4VWX8|ensembl:ENSRNOP00000074079	intact:EBI-6140589|uniprotkb:O08768	psi-mi:oprm_rat(display_long)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Ror-b(gene name synonym)|uniprotkb:Opioid receptor B(gene name synonym)	psi-mi:pld2_rat(display_long)|uniprotkb:Pld2(gene name)|psi-mi:Pld2(display_short)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Koch et al. (2003)	pubmed:12519790|imex:IM-20550	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6140637|imex:IM-20550-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291664.1|refseq:NP_001291666.1|refseq:NP_001291667.1|refseq:NP_001291669.1|rgd:3234|refseq:NP_001033686.1|refseq:NP_001033689.1|refseq:NP_001033690.1|refseq:NP_037203.1|ensembl:ENSRNOG00000018191|refseq:NP_001033688.2|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009314"(response to radiation)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0030425"(dendrite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-111885|reactome:R-RNO-202040|reactome:R-RNO-375276|reactome:R-RNO-418594|ensembl:ENSRNOG00000018191(gene)|ensembl:ENSRNOT00000083308(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)	interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR036871|mint:P70498|rgd:3350|refseq:NP_150641.2|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001683(Phox-like)|interpro:IPR025202|interpro:IPR001849(Pleckstrin-like)|interpro:IPR015679(Phospholipase D)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031526"(brush border membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|reactome:R-RNO-1483166|reactome:R-RNO-2029485|reactome:R-RNO-9013149|reactome:R-RNO-9013404	-	-	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2012/05/31	2014/10/16	rogid:wNrY62jBw3FWtANSbP1ygSZuFc410116	rogid:lHss1RrhpH2K9x19XTxxQoqTYG410116	intact-crc:64818829C3F58AAB|rigid:8bjnrA4HrpX1gr2RpmtCPQ+yxlk	false	sufficient binding region:340-398	sufficient binding region:1-235	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33535	uniprotkb:Q8N6T3	intact:EBI-4392569|uniprotkb:Q62846|uniprotkb:Q64064|uniprotkb:Q64120|uniprotkb:Q2TV20|uniprotkb:Q2TV21|uniprotkb:Q4VWM5|uniprotkb:Q4VWM7|uniprotkb:Q4VWX7|uniprotkb:Q4VWX8|ensembl:ENSRNOP00000074079	intact:EBI-716933|uniprotkb:Q6PK71|uniprotkb:Q96KC4|uniprotkb:Q96T02|uniprotkb:Q9NSU3|uniprotkb:Q9NVF6|uniprotkb:Q9UIL0|uniprotkb:B7ZBI3|uniprotkb:E1P5I9|ensembl:ENSP00000359306|uniprotkb:B7Z3U0|uniprotkb:E7EV62|uniprotkb:B7Z8H8	psi-mi:oprm_rat(display_long)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Ror-b(gene name synonym)|uniprotkb:Opioid receptor B(gene name synonym)	psi-mi:arfg1_human(display_long)|uniprotkb:ADP-ribosylation factor 1 GTPase-activating protein(gene name synonym)|uniprotkb:ARF1-directed GTPase-activating protein(gene name synonym)|uniprotkb:ARFGAP1(gene name)|psi-mi:ARFGAP1(display_short)|uniprotkb:ARF1GAP(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Koch et al. (2003)	pubmed:12519790|imex:IM-20550	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6140648|imex:IM-20550-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291664.1|refseq:NP_001291666.1|refseq:NP_001291667.1|refseq:NP_001291669.1|rgd:3234|refseq:NP_001033686.1|refseq:NP_001033689.1|refseq:NP_001033690.1|refseq:NP_037203.1|ensembl:ENSRNOG00000018191|refseq:NP_001033688.2|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009314"(response to radiation)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0030425"(dendrite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-111885|reactome:R-RNO-202040|reactome:R-RNO-375276|reactome:R-RNO-418594|ensembl:ENSRNOG00000018191(gene)|ensembl:ENSRNOT00000083308(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)	refseq:NP_060679.1|refseq:NP_783202.1|refseq:NP_001268411.1|refseq:NP_001268412.1|refseq:NP_001268413.1|ensembl:ENSG00000101199(gene)|ensembl:ENST00000370283(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR037278|interpro:IPR038508|mint:Q8N6T3|rcsb pdb:3DWD|rcsb pdb:3O47|reactome:R-HSA-381038|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-8856828	-	-	-	figure legend:2a|agonist:DAMGO; increases association of ARFGAP1/ARF1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/05/31	2014/10/16	rogid:wNrY62jBw3FWtANSbP1ygSZuFc410116	rogid:vAIMUqWHtBQzZYe5JJp6WEMXQdo9606	intact-crc:37AEA6C99B8DB8FD|rigid:L9eUyMK8btDPoCAl11nmZ9NGPDQ	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33535	uniprotkb:P70498	intact:EBI-4392569|uniprotkb:Q62846|uniprotkb:Q64064|uniprotkb:Q64120|uniprotkb:Q2TV20|uniprotkb:Q2TV21|uniprotkb:Q4VWM5|uniprotkb:Q4VWM7|uniprotkb:Q4VWX7|uniprotkb:Q4VWX8|ensembl:ENSRNOP00000074079	intact:EBI-6140589|uniprotkb:O08768	psi-mi:oprm_rat(display_long)|uniprotkb:Oprm1(gene name)|psi-mi:Oprm1(display_short)|uniprotkb:Ror-b(gene name synonym)|uniprotkb:Opioid receptor B(gene name synonym)	psi-mi:pld2_rat(display_long)|uniprotkb:Pld2(gene name)|psi-mi:Pld2(display_short)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Koch et al. (2003)	pubmed:12519790|imex:IM-20550	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6140648|imex:IM-20550-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291664.1|refseq:NP_001291666.1|refseq:NP_001291667.1|refseq:NP_001291669.1|rgd:3234|refseq:NP_001033686.1|refseq:NP_001033689.1|refseq:NP_001033690.1|refseq:NP_037203.1|ensembl:ENSRNOG00000018191|refseq:NP_001033688.2|go:"GO:0004979"(beta-endorphin receptor activity)|go:"GO:0004985"(G protein-coupled opioid receptor activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009314"(response to radiation)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0031005"(filamin binding)|go:"GO:0031635"(adenylate cyclase-inhibiting opioid receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032094"(response to food)|go:"GO:0032100"(positive regulation of appetite)|go:"GO:0030425"(dendrite)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0038003"(G protein-coupled opioid receptor signaling pathway)|go:"GO:0038047"(morphine receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042220"(response to cocaine)|go:"GO:0042277"(peptide binding)|go:"GO:0042755"(eating behavior)|go:"GO:0042923"(neuropeptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043278"(response to morphine)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0061358"(negative regulation of Wnt protein secretion)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0080135"(regulation of cellular response to stress)|go:"GO:0097444"(spine apparatus)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000105(Mu opioid receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001418(Opioid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-111885|reactome:R-RNO-202040|reactome:R-RNO-375276|reactome:R-RNO-418594|ensembl:ENSRNOG00000018191(gene)|ensembl:ENSRNOT00000083308(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0002438"(acute inflammatory response to antigenic stimulus)	interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR036871|mint:P70498|rgd:3350|refseq:NP_150641.2|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001683(Phox-like)|interpro:IPR025202|interpro:IPR001849(Pleckstrin-like)|interpro:IPR015679(Phospholipase D)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031526"(brush border membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|reactome:R-RNO-1483166|reactome:R-RNO-2029485|reactome:R-RNO-9013149|reactome:R-RNO-9013404	-	-	-	figure legend:2a|agonist:DAMGO; increases association of ARFGAP1/ARF1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2012/05/31	2014/10/16	rogid:wNrY62jBw3FWtANSbP1ygSZuFc410116	rogid:lHss1RrhpH2K9x19XTxxQoqTYG410116	intact-crc:37AEA6C99B8DB8FD|rigid:L9eUyMK8btDPoCAl11nmZ9NGPDQ	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)