#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9I9N6 uniprotkb:Q9I9L7 intact:EBI-6374201 intact:EBI-6374180|ensembl:ENSDARP00000034228|uniprotkb:A0A2U9DQN4 psi-mi:asc_danre(display_long)|uniprotkb:pycard(gene name)|psi-mi:pycard(display_short)|uniprotkb:asc(gene name synonym)|uniprotkb:asc1(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym) psi-mi:caspa_danre(display_long)|uniprotkb:caspa(gene name)|psi-mi:caspa(display_short)|uniprotkb:caspy(gene name synonym)|uniprotkb:casp1(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Masumoto et al. (2003) pubmed:12464617|imex:IM-17911 taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)") taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6374237|imex:IM-17911-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001315(Caspase Recruitment)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0061702"(inflammasome complex)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR033516|rcsb pdb:5GPP|rcsb pdb:5GPQ refseq:NP_571580.1|ensembl:ENSDARG00000008165(gene)|ensembl:ENSDART00000034544(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061702"(inflammasome complex)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|reactome:R-DRE-168638|reactome:R-DRE-448706|reactome:R-DRE-9008059|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway) - - - figure legend:6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2012/10/22 2014/10/16 rogid:tBDXwBbKMVuYaA3RPLDwNh7aOVM7955 rogid:pj6gCUk4Whhh91KCCw9ayLqDPBI7955 intact-crc:7F4D58223E1B8CCF|rigid:5L++vnquaoiHYTI8MjiCOa85ITI false fluorescent protein tag:?-? green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q9I9L7 uniprotkb:Q9I9N6 intact:EBI-6374180|ensembl:ENSDARP00000034228|uniprotkb:A0A2U9DQN4 intact:EBI-6374201 psi-mi:caspa_danre(display_long)|uniprotkb:caspa(gene name)|psi-mi:caspa(display_short)|uniprotkb:caspy(gene name synonym)|uniprotkb:casp1(gene name synonym) psi-mi:asc_danre(display_long)|uniprotkb:pycard(gene name)|psi-mi:pycard(display_short)|uniprotkb:asc(gene name synonym)|uniprotkb:asc1(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Masumoto et al. (2003) pubmed:12464617|imex:IM-17911 taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)") taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6374178|imex:IM-17911-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_571580.1|ensembl:ENSDARG00000008165(gene)|ensembl:ENSDART00000034544(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061702"(inflammasome complex)|go:"GO:0097194"(execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|reactome:R-DRE-168638|reactome:R-DRE-448706|reactome:R-DRE-9008059|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway) interpro:IPR001315(Caspase Recruitment)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0061702"(inflammasome complex)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR033516|rcsb pdb:5GPP|rcsb pdb:5GPQ - - - figure legend:5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2012/10/22 2014/10/16 rogid:pj6gCUk4Whhh91KCCw9ayLqDPBI7955 rogid:tBDXwBbKMVuYaA3RPLDwNh7aOVM7955 intact-crc:44F05CA808ABF813|rigid:5L++vnquaoiHYTI8MjiCOa85ITI false myc tag:?-?|necessary binding region:1-100(IPR004020) necessary binding region:1-103(IPR004020)|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)