#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P80560 uniprotkb:Q60673 intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym) psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8538971|mint:MINT-8311538 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695|mint:MINT-8311544(identity)|uniprotkb:P80560(original identifier) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8311539(identity)|uniprotkb:Q60673(original identifier) - comment:mint comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint figure legend:F1|comment:mint|partial coverage:partial coverage taxid:4932(baker's yeast-egy48)|taxid:4932(Saccharomyces cerevisiae) - 2012/02/13 2014/10/16 rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 intact-crc:59DF7EAE41D52B93|rigid:5hBuCsyHGs5m6WXeEeBsBLyWldw false binding-associated region:622-1001(MINT-8311547) binding-associated region:?-?(MINT-8311542) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60673 uniprotkb:P18052 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 intact:EBI-6597520|ensembl:ENSMUSP00000076533|uniprotkb:A2AHF2|uniprotkb:Q61808 psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:ptpra_mouse(display_long)|uniprotkb:Ptpra(gene name)|psi-mi:Ptpra(display_short)|uniprotkb:Lrp(gene name synonym)|uniprotkb:Ptpa(gene name synonym)|uniprotkb:LCA-related phosphatase(gene name synonym)|uniprotkb:PTPTY-28(gene name synonym) psi-mi:"MI:0096"(pull down) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539015|mint:MINT-8311552 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8311553(identity)|uniprotkb:Q60673(original identifier) ensembl:ENSMUSG00000027303(gene)|ensembl:ENSMUST00000077303(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099699"(integral component of synaptic membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016336(Receptor tyrosine-protein phosphatase, alpha/epsilon-type)|interpro:IPR027262|interpro:IPR029021|rcsb pdb:1P15|rcsb pdb:1YFO|reactome:R-MMU-375165|reactome:R-MMU-5673001|mint:P18052|refseq:NP_033006.2|mint:MINT-8311560(identity)|uniprotkb:P18052(original identifier) - comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint - figure legend:F5|comment:homomint|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 rogid:2OLnRSJvcMrmaAF1Jw9t/tpt/L410090 intact-crc:8FF8B067E7FFCCA4|rigid:ASd1BtPkyLSTd9l9mZpove8wWVA false binding-associated region:?-?(MINT-8311556)|glutathione s tranferase tag:?-?(MINT-8311558) tag:?-?(MINT-8311563) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P80560 uniprotkb:P18052 intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046 intact:EBI-6597520|ensembl:ENSMUSP00000076533|uniprotkb:A2AHF2|uniprotkb:Q61808 psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym) psi-mi:ptpra_mouse(display_long)|uniprotkb:Ptpra(gene name)|psi-mi:Ptpra(display_short)|uniprotkb:Lrp(gene name synonym)|uniprotkb:Ptpa(gene name synonym)|uniprotkb:LCA-related phosphatase(gene name synonym)|uniprotkb:PTPTY-28(gene name synonym) psi-mi:"MI:0096"(pull down) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8539086|mint:MINT-8311565 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695|mint:MINT-8311566(identity)|uniprotkb:P80560(original identifier) ensembl:ENSMUSG00000027303(gene)|ensembl:ENSMUST00000077303(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099699"(integral component of synaptic membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016336(Receptor tyrosine-protein phosphatase, alpha/epsilon-type)|interpro:IPR027262|interpro:IPR029021|rcsb pdb:1P15|rcsb pdb:1YFO|reactome:R-MMU-375165|reactome:R-MMU-5673001|mint:P18052|refseq:NP_033006.2|mint:MINT-8311573(identity)|uniprotkb:P18052(original identifier) - comment:mint - figure legend:F5|comment:mint|partial coverage:partial coverage taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/02/13 2014/10/16 rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090 rogid:2OLnRSJvcMrmaAF1Jw9t/tpt/L410090 intact-crc:921C64D3F922445D|rigid:xFI/IrRVMDhtOGuV1EbqP/6W2f0 false binding-associated region:622-1001(MINT-8311569)|glutathione s tranferase tag:?-?(MINT-8311571) tag:?-?(MINT-8311576) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P80560 uniprotkb:Q60673 intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym) psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539117|mint:MINT-8312408 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695|mint:MINT-8312409(identity)|uniprotkb:P80560(original identifier) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312416(identity)|uniprotkb:Q60673(original identifier) - comment:mint comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint figure legend:F2|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 intact-crc:AF6B58B09BAA4DFD|rigid:5hBuCsyHGs5m6WXeEeBsBLyWldw false green fluorescent protein tag:?-?(MINT-8312414)|binding-associated region:622-1001(MINT-8312412) tag:?-?(MINT-8312421)|binding-associated region:?-?(MINT-8312419) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60673 uniprotkb:P80560 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046 psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539144|mint:MINT-8312423 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312431(identity)|uniprotkb:Q60673(original identifier) refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695|mint:MINT-8312424(identity)|uniprotkb:P80560(original identifier) - comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint comment:mint figure legend:F2 F4|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090 intact-crc:C5392C81A73989BC|rigid:5hBuCsyHGs5m6WXeEeBsBLyWldw false green fluorescent protein tag:?-?(MINT-8312436)|binding-associated region:?-?(MINT-8312434) binding-associated region:622-1001(MINT-8312427)|tag:?-?(MINT-8312429) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60673 uniprotkb:P18052 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 intact:EBI-6597520|ensembl:ENSMUSP00000076533|uniprotkb:A2AHF2|uniprotkb:Q61808 psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:ptpra_mouse(display_long)|uniprotkb:Ptpra(gene name)|psi-mi:Ptpra(display_short)|uniprotkb:Lrp(gene name synonym)|uniprotkb:Ptpa(gene name synonym)|uniprotkb:LCA-related phosphatase(gene name synonym)|uniprotkb:PTPTY-28(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539189|mint:MINT-8312449 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312450(identity)|uniprotkb:Q60673(original identifier) ensembl:ENSMUSG00000027303(gene)|ensembl:ENSMUST00000077303(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099699"(integral component of synaptic membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016336(Receptor tyrosine-protein phosphatase, alpha/epsilon-type)|interpro:IPR027262|interpro:IPR029021|rcsb pdb:1P15|rcsb pdb:1YFO|reactome:R-MMU-375165|reactome:R-MMU-5673001|mint:P18052|refseq:NP_033006.2|mint:MINT-8312457(identity)|uniprotkb:P18052(original identifier) - comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint - figure legend:F6|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 rogid:2OLnRSJvcMrmaAF1Jw9t/tpt/L410090 intact-crc:E10DB2B795870F57|rigid:ASd1BtPkyLSTd9l9mZpove8wWVA false myc tag:?-?(MINT-8312455)|binding-associated region:?-?(MINT-8312453) binding-associated region:232-528(MINT-8312460) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P80560 uniprotkb:Q60673 intact:EBI-8538944|uniprotkb:P70328|uniprotkb:Q1RLJ1|intact:MINT-8310377|uniprotkb:O09134|ensembl:ENSMUSP00000064046 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 psi-mi:ptpr2_mouse(display_long)|uniprotkb:Phogrin(gene name synonym)|uniprotkb:Protein tyrosine phosphatase-NP(gene name synonym)|uniprotkb:Ptprn2(gene name)|psi-mi:Ptprn2(display_short)|uniprotkb:PTP IA-2beta(gene name synonym) psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539171|mint:MINT-8312438 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035345.2|ensembl:ENSMUSG00000056553(gene)|ensembl:ENSMUST00000070733(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043195"(terminal bouton)|go:"GO:0043235"(receptor complex)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|interpro:IPR038112|reactome:R-MMU-6798695|mint:MINT-8312439(identity)|uniprotkb:P80560(original identifier) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312444(identity)|uniprotkb:Q60673(original identifier) - comment:mint comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint figure legend:F3|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:4Jw+Bh/t4Q1Z67SgT6vJzrO05SM10090 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 intact-crc:BB6FB97B176A03CA|rigid:5hBuCsyHGs5m6WXeEeBsBLyWldw false tag:?-?(MINT-8312442) myc tag:?-?(MINT-8312447) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60673 uniprotkb:P49446 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 intact:EBI-911699|uniprotkb:Q62134|uniprotkb:Q62444|uniprotkb:Q64496|uniprotkb:Q3U369|uniprotkb:Q60986|uniprotkb:Q61042|ensembl:ENSMUSP00000073616|ensembl:ENSMUSP00000147313|ensembl:ENSMUSP00000147957 psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:ptpre_mouse(display_long)|uniprotkb:Ptpre(gene name)|psi-mi:Ptpre(display_short)|uniprotkb:Ptpe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539239|mint:MINT-8312475 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312476(identity)|uniprotkb:Q60673(original identifier) ensembl:ENSMUSG00000041836(gene)|ensembl:ENSMUST00000073961(transcript)|ensembl:ENSMUST00000210833(transcript)|ensembl:ENSMUST00000211140(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007185"(transmembrane receptor protein tyrosine phosphatase signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016336(Receptor tyrosine-protein phosphatase, alpha/epsilon-type)|interpro:IPR029021|refseq:NP_035342.3|refseq:NP_001303607.1|refseq:NP_001303608.1|refseq:NP_001303609.1|refseq:NP_001303610.1|mint:MINT-8312481(identity)|uniprotkb:P49446(original identifier) - comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint - figure legend:F7|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 rogid:/fwPNM0qa16BSImQvahLiLVAgsE10090 intact-crc:AA982472D3942B95|rigid:btZyfpASsHsVI67f0tRl8HbmJ10 false tag:?-?(MINT-8312479) myc tag:?-?(MINT-8312486)|binding-associated region:134-688(MINT-8312484) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60673 uniprotkb:P18052 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 intact:EBI-6597520|ensembl:ENSMUSP00000076533|uniprotkb:A2AHF2|uniprotkb:Q61808 psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:ptpra_mouse(display_long)|uniprotkb:Ptpra(gene name)|psi-mi:Ptpra(display_short)|uniprotkb:Lrp(gene name synonym)|uniprotkb:Ptpa(gene name synonym)|uniprotkb:LCA-related phosphatase(gene name synonym)|uniprotkb:PTPTY-28(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539214|mint:MINT-8312462 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312463(identity)|uniprotkb:Q60673(original identifier) ensembl:ENSMUSG00000027303(gene)|ensembl:ENSMUST00000077303(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099699"(integral component of synaptic membrane)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016336(Receptor tyrosine-protein phosphatase, alpha/epsilon-type)|interpro:IPR027262|interpro:IPR029021|rcsb pdb:1P15|rcsb pdb:1YFO|reactome:R-MMU-375165|reactome:R-MMU-5673001|mint:P18052|refseq:NP_033006.2|mint:MINT-8312470(identity)|uniprotkb:P18052(original identifier) - comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint - figure legend:F6|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 rogid:2OLnRSJvcMrmaAF1Jw9t/tpt/L410090 intact-crc:D9E1DC4BDA771006|rigid:ASd1BtPkyLSTd9l9mZpove8wWVA false myc tag:?-?(MINT-8312468)|binding-associated region:?-?(MINT-8312466) binding-associated region:560-818(MINT-8312473) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q60673 uniprotkb:P28828 intact:EBI-8328895|uniprotkb:E9Q746|intact:MINT-4109182|uniprotkb:Q62129 intact:EBI-8539266|uniprotkb:Q571L8|intact:MINT-129906|uniprotkb:E9QKU4|ensembl:ENSMUSP00000153662 psi-mi:ptprn_mouse(display_long)|uniprotkb:Ptprn(gene name)|psi-mi:Ptprn(display_short)|uniprotkb:Ptp35(gene name synonym)|uniprotkb:PTP IA-2(gene name synonym) psi-mi:ptprm_mouse(display_long)|uniprotkb:Ptprm(gene name)|psi-mi:Ptprm(display_short)|uniprotkb:Kiaa4044(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Gross et al. (2002) mint:MINT-8311532|pubmed:12364328|doi:10.1074/jbc.M208228200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8539261|mint:MINT-8312488 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR021613|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR029021|interpro:IPR029403|interpro:IPR033522|mint:Q60673|interpro:IPR038112|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001553"(luteinization)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030507"(spectrin binding)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051020"(GTPase binding)|go:"GO:1904692"(positive regulation of type B pancreatic cell proliferation)|go:"GO:1990502"(dense core granule maturation)|mint:MINT-8312489(identity)|uniprotkb:Q60673(original identifier) refseq:NP_033010.2|ensembl:ENSMUSG00000033278(gene)|ensembl:ENSMUST00000223982(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007165"(signal transduction)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010842"(retina layer formation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0031175"(neuron projection development)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000998(MAM)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|interpro:IPR041201|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|mint:MINT-8312494(identity)|uniprotkb:P28828(original identifier) - comment:mint|function:Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2|comment:homomint comment:mint|comment:homomint|function:Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control figure legend:F7|comment:homomint|comment:mint|partial coverage:partial coverage taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells) - 2012/02/13 2014/10/16 rogid:TQb5TXNlUbYR79GahakRDLJgGY410090 rogid:79oFyTJxJDcKOqE7MrVsxoTRL2k10090 intact-crc:142D59381990F15B|rigid:4dCiIdnTNfCQ2hV7QaKIUhvJb3s false tag:?-?(MINT-8312492) myc tag:?-?(MINT-8312499)|binding-associated region:?-?(MINT-8312497) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)