#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9I8D1 uniprotkb:P98082 intact:EBI-6307292 intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391 psi-mi:myo6_chick(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:CMY6(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307290|imex:IM-17873-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043531"(ADP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051046"(regulation of secretion)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0031965"(nuclear membrane)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR032412|refseq:NP_990066.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|interpro:IPR036114 ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N - - - figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2012/09/26 2014/10/16 rogid:lh9gxYkGgl2T6Gt5vA/3c6jE4SI9031 rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606 intact-crc:2A2FECF8FFFD0873|rigid:ru2qIihWaOsLBqh+NuUWQIYdNxk false sufficient binding region:846..846-1276 sufficient binding region:550-770 - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P98082 uniprotkb:Q9I8D1 intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391 intact:EBI-6307292 psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_chick(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:CMY6(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307343|imex:IM-17873-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043531"(ADP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051046"(regulation of secretion)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0031965"(nuclear membrane)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR032412|refseq:NP_990066.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|interpro:IPR036114 - - - figure legend:1A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2012/09/26 2014/10/16 rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606 rogid:lh9gxYkGgl2T6Gt5vA/3c6jE4SI9031 intact-crc:892F7DCE86A67E68|rigid:ru2qIihWaOsLBqh+NuUWQIYdNxk false sufficient binding region:550-770 sufficient binding region:846..846-1276 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P98078 uniprotkb:Q9UM54 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0097"(reverse ras recruitment system) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307358|imex:IM-17873-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N - - - figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2012/09/26 2014/10/16 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:E0876470FAFD120B|rigid:6pahMpQ4Z7KVdVlxp6aRLEo3fpk false sufficient binding region:1-717 sufficient binding region:?-c - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P98078 uniprotkb:Q9UM54 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0097"(reverse ras recruitment system) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307376|imex:IM-17873-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N - - - figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2012/09/26 2014/10/16 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:4A24DF6469C3A792|rigid:6pahMpQ4Z7KVdVlxp6aRLEo3fpk false sufficient binding region:1-717 sufficient binding region:?-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P98082 uniprotkb:Q9UM54 intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0018"(two hybrid) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307391|imex:IM-17873-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N - - - figure legend:1C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line) - 2012/09/26 2014/10/16 rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:511BCCD2F9084EF3|rigid:15zXYh6ijlwa22RN0t75lPB+kbI false sufficient binding region:550-770 sufficient binding region:1061-1277 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9I8D1 uniprotkb:P97318 intact:EBI-6307292 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:myo6_chick(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:CMY6(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0096"(pull down) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307483|imex:IM-17873-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043531"(ADP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051046"(regulation of secretion)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0031965"(nuclear membrane)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR032412|refseq:NP_990066.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|interpro:IPR036114 reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - figure legend:4A and 5C|caution:C-terminal region of myoVI as indicated by the authors does not fully match with uniprot sequence|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/09/26 2014/10/16 rogid:lh9gxYkGgl2T6Gt5vA/3c6jE4SI9031 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:BFA64E0CB4F22F15|rigid:I97blmSBWFABend+HvW2XIbJOw8 false glutathione s tranferase tag:n-n|sufficient binding region:1062..1062-1273..1273 mutation decreasing interaction:478-480|35s radiolabel:?-? - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P98078 uniprotkb:Q9I8D1 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 intact:EBI-6307292 psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_chick(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:CMY6(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0096"(pull down) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307422|imex:IM-17873-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043531"(ADP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051046"(regulation of secretion)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0031965"(nuclear membrane)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR032412|refseq:NP_990066.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|interpro:IPR036114 - - - figure legend:2B and 5B|caution:C-terminal region of myoVI as indicated by the authors does not fully match with uniprot sequence|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/09/26 2014/10/16 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 rogid:lh9gxYkGgl2T6Gt5vA/3c6jE4SI9031 intact-crc:3746F5270052ACA9|rigid:FpQmZIFl9SD2Z0QpVDdE5DV3d+g false 35s radiolabel:?-?|mutation disrupting interaction:682-684|mutation decreasing interaction:699-701|sufficient binding region:1-717 glutathione s tranferase tag:n-n|sufficient binding region:1062..1062-1273..1273 - - psi-mi:"MI:0821"(molecular weight estimation by autoradiography) psi-mi:"MI:0821"(molecular weight estimation by autoradiography) uniprotkb:P98078 uniprotkb:Q9I8D1 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 intact:EBI-6307292 psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_chick(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:CMY6(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0096"(pull down) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307406|imex:IM-17873-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043531"(ADP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051046"(regulation of secretion)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0031965"(nuclear membrane)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR032412|refseq:NP_990066.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|interpro:IPR036114 - - - figure legend:2A|caution:C-terminal region of myoVI as indicated by the authors does not fully match with uniprot sequence|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/09/26 2014/10/16 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 rogid:lh9gxYkGgl2T6Gt5vA/3c6jE4SI9031 intact-crc:1F1480952FA6E6B7|rigid:FpQmZIFl9SD2Z0QpVDdE5DV3d+g false - sufficient binding region:1062..1062-1273..1273|glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UM54 uniprotkb:P63010 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451 psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307454|imex:IM-17873-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma) - 2012/09/26 2014/10/16 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606 intact-crc:59A29F3B7B238C2C|rigid:yfG6yQRjWEApsI1FvnMA5H1Zgcs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P98082 uniprotkb:Q9UM54 intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307459|imex:IM-17873-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N - - - figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma) - 2012/09/26 2014/10/16 rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:3E1D2B8FB51B0F18|rigid:15zXYh6ijlwa22RN0t75lPB+kbI false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P98078 uniprotkb:Q9UM54 intact:EBI-1391846|uniprotkb:Q3U3K1|uniprotkb:Q91W56|uniprotkb:Q923E1 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:dab2_mouse(display_long)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307470|imex:IM-17873-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001008702.1|refseq:NP_001032994.1|refseq:NP_075607.2|mint:P98078|refseq:XP_011243626.1|refseq:XP_017171913.1|dip:DIP-39422N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001650"(fibrillar center)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1M7E|rcsb pdb:1P3R|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-8856825|reactome:R-MMU-8856828 go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N - - - figure legend:3B|comment:clathrin heavy chain also precipitated|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/09/26 2014/10/16 rogid:CCerpRI40+Lf1+uFkDr1xJwM5Wg10090 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:17D8D82D73BC1878|rigid:6pahMpQ4Z7KVdVlxp6aRLEo3fpk false sufficient binding region:1-717 sufficient binding region:875-1263|myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UM54 uniprotkb:P97318 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-6307499|imex:IM-17873-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - figure legend:4B|comment:clathrin heavy chain also precipitated|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2012/09/26 2014/10/16 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:D6C259B7C543EB1D|rigid:zqKl3tFcrzJUMk4Y5Tne4saOluw false sufficient binding region:875-1263|myc tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P98082 uniprotkb:Q9UM54 intact:EBI-1171238|uniprotkb:Q13598|uniprotkb:Q9BTY0|uniprotkb:Q9UK04|uniprotkb:A6NES5|intact:EBI-28967074|ensembl:ENSP00000313391 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:dab2_human(display_long)|uniprotkb:DAB2(gene name)|psi-mi:DAB2(display_short)|uniprotkb:DOC2(gene name synonym)|uniprotkb:Differentially-expressed protein 2(gene name synonym)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6307535|imex:IM-17873-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000313391|ensembl:ENST00000339788|ensembl:ENSP00000345508|ensembl:ENST00000509337|ensembl:ENSP00000426245|ensembl:ENST00000545653|ensembl:ENSP00000439919|refseq:NP_001334.2|refseq:NP_001231800.1|ensembl:ENSG00000153071(gene)|ensembl:ENST00000320816(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035026"(leading edge cell differentiation)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:2LSW|rcsb pdb:6O5O|rcsb pdb:6OVF|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-8856825|reactome:R-HSA-8856828|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|dip:DIP-45617N go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N go:"GO:0030136"(clathrin-coated vesicle) - - figure legend:6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-caco2)|taxid:9606(Human Caucasian colon adenocarcinoma) - 2012/09/26 2014/10/16 rogid:DLo0+0XUrWaKw1ycCrIefyVK/YM9606 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:801FAA62E2E30518|rigid:15zXYh6ijlwa22RN0t75lPB+kbI false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:Q9I8D1 uniprotkb:O88797 intact:EBI-6307292 intact:EBI-6109302|uniprotkb:O55048|uniprotkb:O55049|uniprotkb:O55050|uniprotkb:O55051|uniprotkb:O88798|uniprotkb:Q4QRA2 psi-mi:myo6_chick(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:CMY6(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:dab2_rat(display_long)|uniprotkb:Adaptor molecule disabled-2(gene name synonym)|uniprotkb:Differentially expressed in ovarian carcinoma 2(gene name synonym)|uniprotkb:Dab2(gene name)|psi-mi:Dab2(display_short)|uniprotkb:Doc2(gene name synonym)|uniprotkb:C9(gene name synonym)|uniprotkb:Mitogen-responsive phosphoprotein(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Morris et al. (2002) pubmed:11967127|imex:IM-17873 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0486"(UniProt) intact:EBI-6307558|imex:IM-17873-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016459"(myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043531"(ADP binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051046"(regulation of secretion)|go:"GO:0060002"(plus-end directed microfilament motor activity)|go:"GO:0031965"(nuclear membrane)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR032412|refseq:NP_990066.1|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR036961|interpro:IPR027417|interpro:IPR036114 go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0032349"(positive regulation of aldosterone biosynthetic process)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902074"(response to salt)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000298"(regulation of Rho-dependent protein serine/threonine kinase activity)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000860"(positive regulation of aldosterone secretion)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:3H8D|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005178"(integrin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0007588"(excretion)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015031"(protein transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030276"(clathrin binding)|rgd:621007|refseq:NP_077073.1|dip:DIP-60713N|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-8856825|reactome:R-RNO-8856828 - - - figure legend:7 and 8|caution:C-terminal region of myoVI as indicated by the authors does not fully match with uniprot sequence|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-nrk)|taxid:10116(Rattus norvegicus kidney fibroblast cell line NRK) - 2012/09/26 2014/10/16 rogid:lh9gxYkGgl2T6Gt5vA/3c6jE4SI9031 rogid:mbuTEczmft0j0LYuKPkW5PzDf8c10116 intact-crc:497A266512977BD3|rigid:rpzB9rU/STPFLJCRZNjr0rs8448 false sufficient binding region:1035..1035-1077..1077|green fluorescent protein tag:?-? - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)