#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:G3I8R9	uniprotkb:Q6UXS9	intact:EBI-988311|intact:EBI-1557723	intact:EBI-6429619|uniprotkb:D6RBN7	psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name)	psi-mi:caspc_human(display_long)|uniprotkb:CASP12(gene name)|psi-mi:CASP12(display_short)|uniprotkb:UNQ9415/PRO34398(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rao et al. (2002)	imex:IM-18535|pubmed:11943137	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6429648|imex:IM-18535-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129	interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR035713|interpro:IPR033139|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|refseq:NP_001177945.2	-	-	-	figure legend:5c and 5d|comment:The processed, active form of casp12 could also be detected to be interacting with GRP78.|antagonist:ATP or dATP caused a reduction in binding of pro- and active forms of caspase-12 to GRP78, but not any reduction in the binding of caspase-7 to GRP78.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/12/05	2018/09/18	rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029	rogid:9xe25gtxyOFboK1cjk1rrgtV+dA9606	intact-crc:32443C4E0A195DE7|rigid:zFUql01O2Buk9iwsvXvnOfdku+A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:G3I8R9	uniprotkb:P55210	intact:EBI-988311|intact:EBI-1557723	intact:EBI-523958|uniprotkb:B5BU45|uniprotkb:Q5SVL3|uniprotkb:Q13364|uniprotkb:Q96BA0|uniprotkb:Q5SVL0|uniprotkb:Q53YD5|ensembl:ENSP00000298701|ensembl:ENSP00000358321|ensembl:ENSP00000358324|ensembl:ENSP00000480584|uniprotkb:D3DRB8|uniprotkb:B4DQU7	psi-mi:bip_crigr(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:I79_019946(orf name)	psi-mi:casp7_human(display_long)|uniprotkb:ICE-like apoptotic protease 3(gene name synonym)|uniprotkb:Apoptotic protease Mch-3(gene name synonym)|uniprotkb:CMH-1(gene name synonym)|uniprotkb:CASP7(gene name)|psi-mi:CASP7(display_short)|uniprotkb:MCH3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rao et al. (2002)	imex:IM-18535|pubmed:11943137	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6429648|imex:IM-18535-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|rcsb pdb:5O4P|rcsb pdb:6EOB|rcsb pdb:6EOC|rcsb pdb:6EOE|rcsb pdb:6EOF|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|refseq:NP_001233668.1|interpro:IPR029047|interpro:IPR029048|rcsb pdb:7A4V|rcsb pdb:7A4U|rcsb pdb:6ZYH|interpro:IPR042050|rcsb pdb:6H9U|rcsb pdb:6HA7|rcsb pdb:6HAB|interpro:IPR043129	refseq:NP_001218.1|refseq:NP_203124.1|refseq:NP_203125.1|refseq:NP_203126.1|ensembl:ENSG00000165806(gene)|ensembl:ENST00000345633(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|ensembl:ENST00000369315(transcript)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55210|rcsb pdb:1F1J|ensembl:ENST00000369318(transcript)|rcsb pdb:1GQF|ensembl:ENST00000621345(transcript)|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1K86|rcsb pdb:1K88|rcsb pdb:1KMC|rcsb pdb:1MIA|rcsb pdb:1SHJ|go:"GO:0004190"(aspartic-type endopeptidase activity)|rcsb pdb:1SHL|rcsb pdb:2QL5|go:"GO:0004197"(cysteine-type endopeptidase activity)|rcsb pdb:2QL7|go:"GO:0005634"(nucleus)|rcsb pdb:2QL9|rcsb pdb:2QLB|rcsb pdb:2QLF|rcsb pdb:2QLJ|rcsb pdb:3EDR|go:"GO:0005654"(nucleoplasm)|rcsb pdb:3H1P|rcsb pdb:3IBC|rcsb pdb:3IBF|rcsb pdb:3R5K|rcsb pdb:4FDL|rcsb pdb:4FEA|rcsb pdb:4HQ0|rcsb pdb:4HQR|rcsb pdb:4JB8|reactome:R-HSA-111464|reactome:R-HSA-111465|reactome:R-HSA-111469|reactome:R-HSA-264870|rcsb pdb:4JJ8|rcsb pdb:4JR1|rcsb pdb:4JR2|rcsb pdb:4LSZ|rcsb pdb:4ZVO|rcsb pdb:4ZVP|rcsb pdb:4ZVQ|rcsb pdb:4ZVR|rcsb pdb:4ZVS|rcsb pdb:4ZVT|rcsb pdb:4ZVU|rcsb pdb:5IC6|rcsb pdb:5K20|rcsb pdb:5V6U|rcsb pdb:5V6Z|reactome:R-HSA-111459|reactome:R-HSA-111463|refseq:NP_001253986.1|refseq:NP_001253987.1|refseq:NP_001253985.1|refseq:NP_001307840.1|dip:DIP-29973N	-	-	-	figure legend:5c and 5d|comment:The processed, active form of casp12 could also be detected to be interacting with GRP78.|antagonist:ATP or dATP caused a reduction in binding of pro- and active forms of caspase-12 to GRP78, but not any reduction in the binding of caspase-7 to GRP78.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/12/05	2018/09/18	rogid:JdZKgGCixM5M26SXAYdJMRbHSEE10029	rogid:XcSWtfWWnuOKIbAR+TXpkCq5fig9606	intact-crc:32443C4E0A195DE7|rigid:zFUql01O2Buk9iwsvXvnOfdku+A	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)