#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28631	uniprotkb:P28630	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	Bullard et al. (2002)	imex:IM-18577|pubmed:11809766	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6464890|imex:IM-18577-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	figure legend:Fig. 5, Table II|comment:"KD value is for interaction of holA domain III  (P28630) with full-length holB (P28631)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.7x10^-6(molar)	2012/12/18	2014/10/16	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:A6A29DE439E8B6A7|rigid:eetSrME0AAR1AkMX94F/hXtaEQg	false	-	his tag:n-n|biotin tag:n-n|sufficient binding region:207-343	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28630	uniprotkb:P28631	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0071"(molecular sieving)	Bullard et al. (2002)	imex:IM-18577|pubmed:11809766	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6464981|imex:IM-18577-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	crc64:87239A678FE16BE2	-	figure legend:Fig. 6|comment:"KD value is for interaction of holA domain III  (P28630) with full-length holB (P28631)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/18	2015/06/09	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:AF7F6688B44706CF|rigid:deUAsW6oeWBymXuhNzcWBBFDtho	false	biotin tag:n-n|his tag:n-n|sufficient binding region:207-343	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28630	uniprotkb:P06710-2	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	intact:EBI-2604194	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Bullard et al. (2002)	imex:IM-18577|pubmed:11809766	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6464981|imex:IM-18577-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	intact:EBI-549140(isoform-parent)	-	crc64:87239A678FE16BE2	isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)."	figure legend:Fig. 6|comment:"KD value is for interaction of holA domain III  (P28630) with full-length holB (P28631)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/18	2015/06/09	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333	intact-crc:AF7F6688B44706CF|rigid:deUAsW6oeWBymXuhNzcWBBFDtho	false	biotin tag:n-n|his tag:n-n|sufficient binding region:207-343	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710-1	uniprotkb:P28630	intact:EBI-6464728	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:p06710-1(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0030"(cross-linking study)	Bullard et al. (2002)	imex:IM-18577|pubmed:11809766	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6464973|imex:IM-18577-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-549140(isoform-parent)	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	isoform-comment:"Produced by full-length translation of the dnaX gene. This isoform is essential, constructs that express only the gamma isoform are not viable (Ref.14)."	crc64:87239A678FE16BE2	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/18	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:F911F32A6B330B48|rigid:6ChVFA7VNppGywQHr+1kPsNm+z8	false	-	biotin tag:c-c|his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P28630	uniprotkb:P06710-2	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	intact:EBI-2604194	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Bullard et al. (2002)	imex:IM-18577|pubmed:11809766	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6464933|imex:IM-18577-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	intact:EBI-549140(isoform-parent)	-	crc64:87239A678FE16BE2	isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)."	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/18	2015/06/09	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333	intact-crc:A30BB5F48749DDF6|rigid:Ceu1IMsEBVHMnoKSpcj52v3iJjA	false	his tag:c-c|biotin tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)