#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NPP4	uniprotkb:Q9NPP4	intact:EBI-1222527|uniprotkb:Q96J81|uniprotkb:Q96J82|uniprotkb:Q96J83|uniprotkb:D6W580|uniprotkb:B2RBQ3|uniprotkb:A8K9F8|uniprotkb:B3KTF0|ensembl:ENSP00000354159|ensembl:ENSP00000385428	intact:EBI-1222527|uniprotkb:Q96J81|uniprotkb:Q96J82|uniprotkb:Q96J83|uniprotkb:D6W580|uniprotkb:B2RBQ3|uniprotkb:A8K9F8|uniprotkb:B3KTF0|ensembl:ENSP00000354159|ensembl:ENSP00000385428	psi-mi:nlrc4_human(display_long)|uniprotkb:NLRC4(gene name)|psi-mi:NLRC4(display_short)|uniprotkb:CLAN(gene name synonym)|uniprotkb:CLAN1(gene name synonym)|uniprotkb:UNQ6189/PRO20215(orf name)|uniprotkb:CARD12(gene name synonym)|uniprotkb:IPAF(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym)|uniprotkb:CARD, LRR, and NACHT-containing protein(gene name synonym)	psi-mi:nlrc4_human(display_long)|uniprotkb:NLRC4(gene name)|psi-mi:NLRC4(display_short)|uniprotkb:CLAN(gene name synonym)|uniprotkb:CLAN1(gene name synonym)|uniprotkb:UNQ6189/PRO20215(orf name)|uniprotkb:CARD12(gene name synonym)|uniprotkb:IPAF(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym)|uniprotkb:CARD, LRR, and NACHT-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Poyet et al. (2001)	imex:IM-17735|pubmed:11390368|mint:MINT-5214133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6285888|imex:IM-17735-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186067.1|refseq:NP_001186068.1|refseq:NP_067032.3|refseq:NP_001289433.1|dip:DIP-38428N|ensembl:ENSG00000091106(gene)|ensembl:ENST00000360906(transcript)|ensembl:ENST00000402280(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:6K8J|rcsb pdb:6MKS|rcsb pdb:6N1I|reactome:R-HSA-6803207|reactome:R-HSA-844623	refseq:NP_001186067.1|refseq:NP_001186068.1|refseq:NP_067032.3|refseq:NP_001289433.1|dip:DIP-38428N|ensembl:ENSG00000091106(gene)|ensembl:ENST00000360906(transcript)|ensembl:ENST00000402280(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:6K8J|rcsb pdb:6MKS|rcsb pdb:6N1I|reactome:R-HSA-6803207|reactome:R-HSA-844623	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/08/31	2014/10/16	rogid:9q8oK2jo8kCYn8rHEwkS8Y0g+9Y9606	rogid:9q8oK2jo8kCYn8rHEwkS8Y0g+9Y9606	intact-crc:2F1CE9AFE86CF3E9|rigid:rFPZVQIjM9NKyzRPD/4ENVaIa5g	false	flag tag:?-?|necessary binding region:1-88(IPR001315)	t7 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29466	uniprotkb:Q9NPP4	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	intact:EBI-1222527|uniprotkb:Q96J81|uniprotkb:Q96J82|uniprotkb:Q96J83|uniprotkb:D6W580|uniprotkb:B2RBQ3|uniprotkb:A8K9F8|uniprotkb:B3KTF0|ensembl:ENSP00000354159|ensembl:ENSP00000385428	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:nlrc4_human(display_long)|uniprotkb:NLRC4(gene name)|psi-mi:NLRC4(display_short)|uniprotkb:CLAN(gene name synonym)|uniprotkb:CLAN1(gene name synonym)|uniprotkb:UNQ6189/PRO20215(orf name)|uniprotkb:CARD12(gene name synonym)|uniprotkb:IPAF(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym)|uniprotkb:CARD, LRR, and NACHT-containing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Poyet et al. (2001)	imex:IM-17735|pubmed:11390368|mint:MINT-5214133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6285899|imex:IM-17735-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	refseq:NP_001186067.1|refseq:NP_001186068.1|refseq:NP_067032.3|refseq:NP_001289433.1|dip:DIP-38428N|ensembl:ENSG00000091106(gene)|ensembl:ENST00000360906(transcript)|ensembl:ENST00000402280(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:6K8J|rcsb pdb:6MKS|rcsb pdb:6N1I|reactome:R-HSA-6803207|reactome:R-HSA-844623	-	-	-	figure legend:3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2012/08/31	2014/10/16	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rogid:9q8oK2jo8kCYn8rHEwkS8Y0g+9Y9606	intact-crc:7CC2615DB1EB6B11|rigid:BwG1gMZ/kqXyIpIn++QZ6Ppd+Mg	false	t7 tag:?-?|sufficient binding region:1-94(IPR001315)	flag tag:?-?|necessary binding region:1-88(IPR001315)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NPP4	uniprotkb:Q9NPP4	intact:EBI-1222527|uniprotkb:Q96J81|uniprotkb:Q96J82|uniprotkb:Q96J83|uniprotkb:D6W580|uniprotkb:B2RBQ3|uniprotkb:A8K9F8|uniprotkb:B3KTF0|ensembl:ENSP00000354159|ensembl:ENSP00000385428	intact:EBI-1222527|uniprotkb:Q96J81|uniprotkb:Q96J82|uniprotkb:Q96J83|uniprotkb:D6W580|uniprotkb:B2RBQ3|uniprotkb:A8K9F8|uniprotkb:B3KTF0|ensembl:ENSP00000354159|ensembl:ENSP00000385428	psi-mi:nlrc4_human(display_long)|uniprotkb:NLRC4(gene name)|psi-mi:NLRC4(display_short)|uniprotkb:CLAN(gene name synonym)|uniprotkb:CLAN1(gene name synonym)|uniprotkb:UNQ6189/PRO20215(orf name)|uniprotkb:CARD12(gene name synonym)|uniprotkb:IPAF(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym)|uniprotkb:CARD, LRR, and NACHT-containing protein(gene name synonym)	psi-mi:nlrc4_human(display_long)|uniprotkb:NLRC4(gene name)|psi-mi:NLRC4(display_short)|uniprotkb:CLAN(gene name synonym)|uniprotkb:CLAN1(gene name synonym)|uniprotkb:UNQ6189/PRO20215(orf name)|uniprotkb:CARD12(gene name synonym)|uniprotkb:IPAF(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym)|uniprotkb:CARD, LRR, and NACHT-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Poyet et al. (2001)	imex:IM-17735|pubmed:11390368|mint:MINT-5214133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6285930|imex:IM-17735-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186067.1|refseq:NP_001186068.1|refseq:NP_067032.3|refseq:NP_001289433.1|dip:DIP-38428N|ensembl:ENSG00000091106(gene)|ensembl:ENST00000360906(transcript)|ensembl:ENST00000402280(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:6K8J|rcsb pdb:6MKS|rcsb pdb:6N1I|reactome:R-HSA-6803207|reactome:R-HSA-844623	refseq:NP_001186067.1|refseq:NP_001186068.1|refseq:NP_067032.3|refseq:NP_001289433.1|dip:DIP-38428N|ensembl:ENSG00000091106(gene)|ensembl:ENST00000360906(transcript)|ensembl:ENST00000402280(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:6K8J|rcsb pdb:6MKS|rcsb pdb:6N1I|reactome:R-HSA-6803207|reactome:R-HSA-844623	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/31	2014/10/16	rogid:9q8oK2jo8kCYn8rHEwkS8Y0g+9Y9606	rogid:9q8oK2jo8kCYn8rHEwkS8Y0g+9Y9606	intact-crc:0327FBBEB524E65E|rigid:rFPZVQIjM9NKyzRPD/4ENVaIa5g	false	sufficient binding region:1-88(IPR001315)|glutathione s tranferase tag:c-c	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P29466	uniprotkb:Q9NPP4	intact:EBI-516667|uniprotkb:B5MDZ1|uniprotkb:Q53EY6|uniprotkb:Q6DMQ1|uniprotkb:Q6GSS3|uniprotkb:Q6PI75|uniprotkb:Q9UCN3|ensembl:ENSP00000410076|ensembl:ENSP00000433138	intact:EBI-1222527|uniprotkb:Q96J81|uniprotkb:Q96J82|uniprotkb:Q96J83|uniprotkb:D6W580|uniprotkb:B2RBQ3|uniprotkb:A8K9F8|uniprotkb:B3KTF0|ensembl:ENSP00000354159|ensembl:ENSP00000385428	psi-mi:casp1_human(display_long)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)|uniprotkb:CASP1(gene name)|psi-mi:CASP1(display_short)|uniprotkb:IL1BC(gene name synonym)|uniprotkb:IL1BCE(gene name synonym)	psi-mi:nlrc4_human(display_long)|uniprotkb:NLRC4(gene name)|psi-mi:NLRC4(display_short)|uniprotkb:CLAN(gene name synonym)|uniprotkb:CLAN1(gene name synonym)|uniprotkb:UNQ6189/PRO20215(orf name)|uniprotkb:CARD12(gene name synonym)|uniprotkb:IPAF(gene name synonym)|uniprotkb:Caspase recruitment domain-containing protein 12(gene name synonym)|uniprotkb:Ice protease-activating factor(gene name synonym)|uniprotkb:CARD, LRR, and NACHT-containing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Poyet et al. (2001)	imex:IM-17735|pubmed:11390368|mint:MINT-5214133	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6285947|imex:IM-17735-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001214.1|refseq:NP_150634.1|refseq:NP_150635.1|refseq:NP_150636.1|refseq:NP_150637.1|refseq:NP_001244047.1|refseq:NP_001244048.1|dip:DIP-175N|rcsb pdb:5FNA|rcsb pdb:5MMV|rcsb pdb:5MTK|rcsb pdb:6BZ9|rcsb pdb:6F6R|rcsb pdb:6KN0|rcsb pdb:6PZP|rcsb pdb:6VIE|rcsb pdb:7KEU|reactome:R-HSA-168638|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-6803207|reactome:R-HSA-844456|reactome:R-HSA-844615|reactome:R-HSA-844623|reactome:R-HSA-9008059|reactome:R-HSA-9660826|ensembl:ENSG00000137752(gene)|ensembl:ENST00000436863(transcript)|ensembl:ENST00000533400(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|rcsb pdb:1BMQ|rcsb pdb:1IBC|rcsb pdb:1ICE|rcsb pdb:1RWK|rcsb pdb:1RWM|rcsb pdb:1RWN|rcsb pdb:1RWO|rcsb pdb:1RWP|rcsb pdb:1RWV|rcsb pdb:1RWW|rcsb pdb:1RWX|rcsb pdb:1SC1|rcsb pdb:1SC3|rcsb pdb:1SC4|rcsb pdb:2FQQ|rcsb pdb:2H48|rcsb pdb:2H4W|rcsb pdb:2H4Y|rcsb pdb:2H51|rcsb pdb:2H54|rcsb pdb:2HBQ|rcsb pdb:2HBR|rcsb pdb:2HBY|rcsb pdb:2HBZ|rcsb pdb:3D6F|rcsb pdb:3D6H|rcsb pdb:3D6M|rcsb pdb:3E4C|rcsb pdb:3NS7	refseq:NP_001186067.1|refseq:NP_001186068.1|refseq:NP_067032.3|refseq:NP_001289433.1|dip:DIP-38428N|ensembl:ENSG00000091106(gene)|ensembl:ENST00000360906(transcript)|ensembl:ENST00000402280(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016045"(detection of bacterium)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070269"(pyroptosis)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0089720"(caspase binding)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR032675|interpro:IPR040535|interpro:IPR042220|rcsb pdb:6K8J|rcsb pdb:6MKS|rcsb pdb:6N1I|reactome:R-HSA-6803207|reactome:R-HSA-844623	-	-	-	figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/08/31	2014/10/16	rogid:fNWee65mDN6re+Zks1Z1WAbwZL89606	rogid:9q8oK2jo8kCYn8rHEwkS8Y0g+9Y9606	intact-crc:56089159E0BD5105|rigid:BwG1gMZ/kqXyIpIn++QZ6Ppd+Mg	false	35s radiolabel:?-?	glutathione s tranferase tag:c-c|sufficient binding region:1-88(IPR001315)	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)