#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53669	-	intact:EBI-9029751	-	psi-mi:limk1_rat(display_long)|uniprotkb:Limk1(gene name)|psi-mi:Limk1(display_short)|uniprotkb:Limk(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Sumi et al. (2001)	imex:IM-18843|pubmed:11340065	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-9029749|imex:IM-18843-1	-	-	psi-mi:"MI:0499"(unspecified role)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	reactome:R-RNO-2029482|reactome:R-RNO-399954|reactome:R-RNO-5627123|interpro:IPR011009(Protein kinase-like)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001781(Zinc finger, LIM-type)|rgd:62055|interpro:IPR036034|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	-	-	-	-	figure legend:"Fig 1A, 2B (left), 2C (lanes 1,2,5)."|comment:"LIMK1 autophosphorylation was stimulated by the presence of the dominant active form of Cdc42, Cdc42V12, but not the ROCK inhibitor, Y-27632. LIMK1 autophosphorylation was not affected in the presence of dominant active form of MRCK-alpha: MRCK-deltaC, or in the presence of the kinase dead form: MRCK-deltaC/KD. LIMK1 autophosphorylation was enhanced in the presence of wild type MRCK-alpha and wild type ROCK."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/13	2014/10/16	rogid:PGpkbuBR5vMTEb610yuK1iO4jWI10116	-	intact-crc:95B49A56CFEE720E	false	ha tag:c-c	-	-	-	psi-mi:"MI:0833"(autoradiography)	-
uniprotkb:P53669	uniprotkb:O54874	intact:EBI-9029751	intact:EBI-689253	psi-mi:limk1_rat(display_long)|uniprotkb:Limk1(gene name)|psi-mi:Limk1(display_short)|uniprotkb:Limk(gene name synonym)	psi-mi:mrcka_rat(display_long)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase alpha(gene name synonym)|uniprotkb:Cdc42bpa(gene name)|psi-mi:Cdc42bpa(display_short)|uniprotkb:Pk428(gene name synonym)|uniprotkb:CDC42-binding protein kinase alpha(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sumi et al. (2001)	imex:IM-18843|pubmed:11340065	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-9029866|imex:IM-18843-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-2029482|reactome:R-RNO-399954|reactome:R-RNO-5627123|interpro:IPR011009(Protein kinase-like)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001781(Zinc finger, LIM-type)|rgd:62055|interpro:IPR036034|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0043005"(neuron projection)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	rgd:621406|refseq:NP_446109.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR031597|rcsb pdb:4AW2|interpro:IPR026611|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013406	-	-	-	figure legend:Fig 3B.|comment:The phosphorylation of LIMK1-KD by MRCK-alpha was shown only using a C-terminal truncated MRCK-deltaC fragment, and not using a full length MRCK-alpha.|causality statement:P53669 increases activity of O54874|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/13	2014/10/16	rogid:PGpkbuBR5vMTEb610yuK1iO4jWI10116	rogid:oq31Mwavu9Tt7QfxaQYlPf8eS9Y10116	intact-crc:BF2EC4E200C999A7|rigid:1Sf5b4xU9v/6QThC0L2FI1OIieA	false	sufficient binding region:?-?|glutathione s tranferase tag:?-?	myc tag:?-?|sufficient binding region:1-574|mutation disrupting interaction rate:106-106	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P53670	uniprotkb:O54874	intact:EBI-9029889|ensembl:ENSRNOP00000026032	intact:EBI-689253	psi-mi:limk2_rat(display_long)|uniprotkb:Limk2(gene name)|psi-mi:Limk2(display_short)	psi-mi:mrcka_rat(display_long)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase alpha(gene name synonym)|uniprotkb:Cdc42bpa(gene name)|psi-mi:Cdc42bpa(display_short)|uniprotkb:Pk428(gene name synonym)|uniprotkb:CDC42-binding protein kinase alpha(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Sumi et al. (2001)	imex:IM-18843|pubmed:11340065	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-9029887|imex:IM-18843-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:62056|refseq:NP_077049.2|refseq:XP_006251298.1|ensembl:ENSRNOG00000019000(gene)|ensembl:ENSRNOT00000026032(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0060322"(head development)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR036034|interpro:IPR001245(Tyrosine protein kinase)	rgd:621406|refseq:NP_446109.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR031597|rcsb pdb:4AW2|interpro:IPR026611|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013406	-	-	-	figure legend:"Fig 3B (lanes 5,6)."|comment:The phosphorylation of LIMK2 by MRCK-alpha was shown using only the C-terminal truncated MRCK-deltaC fragment and not using the full length MRCK-alpha.|causality statement:O54874 increases activity of P53670|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/13	2014/10/16	rogid:Uk7ec1Y1k42m9JD7mxS1vEqEg0I10116	rogid:oq31Mwavu9Tt7QfxaQYlPf8eS9Y10116	intact-crc:B69675A6D1315484|rigid:hq+UDf9FlfbDLQ3C3U0zQTRIwyU	false	glutathione s tranferase tag:?-?|sufficient binding region:?-?	myc tag:?-?|sufficient binding region:1-574|mutation disrupting interaction rate:106-106	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O54874	-	intact:EBI-689253	-	psi-mi:mrcka_rat(display_long)|uniprotkb:Myotonic dystrophy kinase-related CDC42-binding kinase alpha(gene name synonym)|uniprotkb:Cdc42bpa(gene name)|psi-mi:Cdc42bpa(display_short)|uniprotkb:Pk428(gene name synonym)|uniprotkb:CDC42-binding protein kinase alpha(gene name synonym)	-	psi-mi:"MI:0424"(protein kinase assay)	Sumi et al. (2001)	imex:IM-18843|pubmed:11340065	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-9029929|imex:IM-18843-4	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	rgd:621406|refseq:NP_446109.1|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014930(DMPK coiled coil)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR031597|rcsb pdb:4AW2|interpro:IPR026611|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0016477"(cell migration)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013406	-	-	-	-	figure legend:"Fig 3B (lanes 1,3,5), 3C."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/12/13	2014/10/16	rogid:oq31Mwavu9Tt7QfxaQYlPf8eS9Y10116	-	intact-crc:AA811685A52934E4	false	mutation disrupting interaction:106-106|myc tag:?-?|sufficient binding region:1-574	-	-	-	psi-mi:"MI:0833"(autoradiography)	-