#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P28630 uniprotkb:P28631 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466545|imex:IM-18588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 - figure legend:Table II|complex-properties:tau complex, part of DNA Polymerase complex|complex-synonym:tau complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2014/10/16 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 intact-crc:36B9BE7A5D77AECB|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28905 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466545|imex:IM-18588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 crc64:7FEFFC359B28AA88 figure legend:Table II|complex-properties:tau complex, part of DNA Polymerase complex|complex-synonym:tau complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2014/10/16 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:36B9BE7A5D77AECB|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28632 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466545|imex:IM-18588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 - figure legend:Table II|complex-properties:tau complex, part of DNA Polymerase complex|complex-synonym:tau complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2014/10/16 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:36B9BE7A5D77AECB|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P06710-1 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-6464728 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:p06710-1(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466545|imex:IM-18588-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF intact:EBI-549140(isoform-parent) go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 isoform-comment:"Produced by full-length translation of the dnaX gene. This isoform is essential, constructs that express only the gamma isoform are not viable (Ref.14)." figure legend:Table II|complex-properties:tau complex, part of DNA Polymerase complex|complex-synonym:tau complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2014/10/16 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 intact-crc:36B9BE7A5D77AECB|rigid:trFktjtS766fchoLI2mkkpTmdCw false - - 1 3 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28631 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466570|imex:IM-18588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG - crc64:87239A678FE16BE2 - figure legend:Fig. 1, 2d, e, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 intact-crc:6E80FE5F8B937869|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28905 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466570|imex:IM-18588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU - crc64:87239A678FE16BE2 crc64:7FEFFC359B28AA88 figure legend:Fig. 1, 2d, e, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:6E80FE5F8B937869|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28632 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466570|imex:IM-18588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU - crc64:87239A678FE16BE2 - figure legend:Fig. 1, 2d, e, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:6E80FE5F8B937869|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P06710-1 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-6464728 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:p06710-1(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466570|imex:IM-18588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF intact:EBI-549140(isoform-parent) - crc64:87239A678FE16BE2 isoform-comment:"Produced by full-length translation of the dnaX gene. This isoform is essential, constructs that express only the gamma isoform are not viable (Ref.14)." figure legend:Fig. 1, 2d, e, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 intact-crc:6E80FE5F8B937869|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P06710-2 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-2604194 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466570|imex:IM-18588-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF intact:EBI-549140(isoform-parent) - crc64:87239A678FE16BE2 isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." figure legend:Fig. 1, 2d, e, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 intact-crc:6E80FE5F8B937869|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28631 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466591|imex:IM-18588-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 - figure legend:Fig. 1, 2a, 3, Table II|complex-properties:Gamma complex, part of DNA Polymerase complex|complex-synonym:gamma complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2015/06/09 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 intact-crc:8BB6E924A0551894|rigid:x3MIYCKqE0irmXlfcgCY6ntgSB4 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28905 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466591|imex:IM-18588-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 crc64:7FEFFC359B28AA88 figure legend:Fig. 1, 2a, 3, Table II|complex-properties:Gamma complex, part of DNA Polymerase complex|complex-synonym:gamma complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2015/06/09 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:8BB6E924A0551894|rigid:x3MIYCKqE0irmXlfcgCY6ntgSB4 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28632 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466591|imex:IM-18588-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 - figure legend:Fig. 1, 2a, 3, Table II|complex-properties:Gamma complex, part of DNA Polymerase complex|complex-synonym:gamma complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2015/06/09 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:8BB6E924A0551894|rigid:x3MIYCKqE0irmXlfcgCY6ntgSB4 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P06710-2 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-2604194 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466591|imex:IM-18588-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF intact:EBI-549140(isoform-parent) go:"GO:0043846"(DNA polymerase III, clamp loader complex) crc64:87239A678FE16BE2 isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." figure legend:Fig. 1, 2a, 3, Table II|complex-properties:Gamma complex, part of DNA Polymerase complex|complex-synonym:gamma complex; clamp-loading complex|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2015/06/09 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 intact-crc:8BB6E924A0551894|rigid:x3MIYCKqE0irmXlfcgCY6ntgSB4 false - - 1 3 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28631 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466581|imex:IM-18588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG - crc64:87239A678FE16BE2 - figure legend:Fig. 1, 2b, c, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333 intact-crc:DD3183FAAFF36B81|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28905 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549169|uniprotkb:P11649|uniprotkb:Q2M650|ensemblbacteria:AAC77216|ensemblbacteria:BAE78256 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:holc_ecoli(display_long)|uniprotkb:holC(gene name)|psi-mi:holC(display_short)|uniprotkb:b4259(locus name)|uniprotkb:JW4216(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466581|imex:IM-18588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418680.1|refseq:WP_000786400.1|dip:DIP-9933N|ensemblbacteria:AAC77216(transcript)|ensemblbacteria:b4259(gene)|ensemblbacteria:BAE78256(gene)|ensemblbacteria:BAE78256(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0009314"(response to radiation)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0043847"(DNA polymerase III, clamp loader chi/psi subcomplex)|interpro:IPR007459(DNA polymerase III chi subunit, HolC)|interpro:IPR036768|rcsb pdb:1EM8|rcsb pdb:3SXU - crc64:87239A678FE16BE2 crc64:7FEFFC359B28AA88 figure legend:Fig. 1, 2b, c, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:tHXN16a+ZMkxJMQYo0Gd6NTQSqQ83333 intact-crc:DD3183FAAFF36B81|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P28632 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466581|imex:IM-18588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU - crc64:87239A678FE16BE2 - figure legend:Fig. 1, 2b, c, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333 intact-crc:DD3183FAAFF36B81|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P06710-1 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-6464728 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:p06710-1(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466581|imex:IM-18588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF intact:EBI-549140(isoform-parent) - crc64:87239A678FE16BE2 isoform-comment:"Produced by full-length translation of the dnaX gene. This isoform is essential, constructs that express only the gamma isoform are not viable (Ref.14)." figure legend:Fig. 1, 2b, c, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333 intact-crc:DD3183FAAFF36B81|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P28630 uniprotkb:P06710-2 intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287 intact:EBI-2604194 psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name) psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-6466581|imex:IM-18588-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF intact:EBI-549140(isoform-parent) - crc64:87239A678FE16BE2 isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." figure legend:Fig. 1, 2b, c, 3, Table II|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2018/05/08 rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 intact-crc:DD3183FAAFF36B81|rigid:cEYE2mh2/h5hZ+xAKGbPMxbmpm8 false - - 1 2 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P06710-2 uniprotkb:P06710-2 intact:EBI-2604194 intact:EBI-2604194 psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:p06710-2(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Pritchard et al. (2000) pubmed:11101526|imex:IM-18588 taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-6466611|imex:IM-18588-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-549140(isoform-parent) intact:EBI-549140(isoform-parent) go:"GO:0043846"(DNA polymerase III, clamp loader complex) isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." isoform-comment:"Formed by programmed ribosomal frameshifting to a premature stop codon in the -1 frame at codon 430, the last residue is thus Glu and not Ser. Mutants which remove the frameshift are viable, suggesting strongly that gamma is not essential for viability (Ref.14)." figure legend:Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2012/12/20 2015/06/09 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 rogid:JMH64mXrcW06P+gZXBrJZS0hu9w83333 intact-crc:727D8727A3911004|rigid:cA3srjVRbgE896xTF2QoKZUt0LA false - - 4 0 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)