#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46935	uniprotkb:Q9JLJ0	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-643664|uniprotkb:Q9EQI0|ensembl:ENSMUSP00000023143|ensembl:ENSMUSP00000112667	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:litaf_mouse(display_long)|uniprotkb:LITAF-like protein(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 3(gene name synonym)|uniprotkb:Estrogen-enhanced transcript protein(gene name synonym)|uniprotkb:Litaf(gene name)|psi-mi:Litaf(display_short)|uniprotkb:N4wbp3(gene name synonym)|uniprotkb:Tbx1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304081|imex:IM-17722-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	refseq:NP_064364.1|interpro:IPR037519|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|ensembl:ENSMUSG00000022500(gene)|ensembl:ENSMUST00000023143(transcript)|ensembl:ENSMUST00000117360(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|refseq:XP_006522490.1	-	-	-	figure legend:table 1, fig 2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:ZEM7+GSIEXmET3ixryvhuaMkiYk10090	intact-crc:577B9F4916AC0852|rigid:SC0oPHtGQw7Hw1JcozBSxJfbC3M	false	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:249..249-493..493	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97764	uniprotkb:P46935	intact:EBI-6304160|uniprotkb:Q8WUP5|uniprotkb:Q99J20|ensembl:ENSMUSP00000032111	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:wbp1_mouse(display_long)|uniprotkb:Wbp1(gene name)|psi-mi:Wbp1(display_short)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304152|imex:IM-17722-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077392.1|refseq:NP_058037.2|ensembl:ENSMUSG00000030035(gene)|ensembl:ENSMUST00000032111(transcript)|go:"GO:0050699"(WW domain binding)|interpro:IPR021684|mint:P97764	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:table 1, fig 2h|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:Mt3CCbYUeFL8Ai8BSbLkGobn13Q10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:6BF3970CEC721D33|rigid:zmstzEJQKVqL23v9EbESvuv6gDk	false	-	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:249..249-493..493	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYK7	uniprotkb:P46935	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304073|imex:IM-17722-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:table 1, fig 2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:F6484C3E68FF4B9E|rigid:QWdwEUA/ZNWioxC0QFnwmWZkGXQ	false	-	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46935	uniprotkb:Q9EQG5	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304006|ensembl:ENSMUSP00000090931|ensembl:ENSMUSP00000131530	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:bean1_mouse(display_long)|uniprotkb:Bean1(gene name)|psi-mi:Bean1(display_short)|uniprotkb:Brain-expressed protein associating with Nedd4(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304017|imex:IM-17722-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000031872(gene)|ensembl:ENSMUST00000093245(transcript)|ensembl:ENSMUST00000167633(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039352|refseq:NP_001135396.1|refseq:XP_006531333.1	-	-	-	figure legend:table 1, fig 2g|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:KLmexu7itmtgfQoV+FKKSpQefwQ10090	intact-crc:6FDE07C2D4AD11F6|rigid:MPJJUpqKtYH1Qrv0N+kFWou2LeI	false	glutathione s tranferase tag:n-n|sufficient binding region:249..249-493..493|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R0W6	uniprotkb:P46935	intact:EBI-6304119|ensembl:ENSMUSP00000025293|ensembl:ENSMUSP00000158314|uniprotkb:Q9EQH8	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:nfip1_mouse(display_long)|uniprotkb:Ndfip1(gene name)|psi-mi:Ndfip1(display_short)|uniprotkb:N4wbp5(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 5(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304111|imex:IM-17722-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024425(gene)|ensembl:ENSMUST00000025293(transcript)|ensembl:ENSMUST00000236085(transcript)|go:"GO:0002761"(regulation of myeloid leukocyte differentiation)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045202"(synapse)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051224"(negative regulation of protein transport)|interpro:IPR019325|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:NP_075372.1|refseq:XP_006526212.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:table 1, fig 2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:57xO5IsBQHQhOC19LSjF8hx1V+810090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:C78F216838510E69|rigid:KBWNmhIgkNDiGtHVU3F4hR+hwY0	false	-	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:249..249-493..493	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46935	uniprotkb:Q8R182	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304055|ensembl:ENSMUSP00000007981|ensembl:ENSMUSP00000148014|uniprotkb:Q9EQI2	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:tmg2_mouse(display_long)|uniprotkb:Prrg2(gene name)|psi-mi:Prrg2(display_short)|uniprotkb:N4wbp1(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 1(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304047|imex:IM-17722-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000007837(gene)|ensembl:ENSMUST00000210690(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|ensembl:ENSMUST00000007981(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|refseq:XP_011249190.1|refseq:NP_075375.1|refseq:XP_006541125.1|refseq:XP_006541126.1	-	-	-	figure legend:table 1, fig 2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:VHlrmvld4rX8zQEgSD/q7U1h9NA10090	intact-crc:BB2CFB644A515BB9|rigid:jtM9mpsnDhSCrw8aoCsyKARIPCA	false	glutathione s tranferase tag:n-n|sufficient binding region:249..249-493..493|32p radiolabel:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97765	uniprotkb:P46935	intact:EBI-6304181|ensembl:ENSMUSP00000074204|uniprotkb:A2A860	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:wbp2_mouse(display_long)|uniprotkb:Wbp2(gene name)|psi-mi:Wbp2(display_short)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304173|imex:IM-17722-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034341(gene)|ensembl:ENSMUST00000074628(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043627"(response to estrogen)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|interpro:IPR004182(GRAM)|interpro:IPR033598|interpro:IPR044852|mint:P97765|refseq:NP_001334571.1|refseq:NP_058548.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:table 1, fig 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:UAH2fbVTGZVChfiOofvZGHoQ78o10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:86D3F50C0B606DBE|rigid:uEAeCoD0w74L22l+/MeRNKd8Fag	false	-	32p radiolabel:?-?|sufficient binding region:249..249-493..493|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D7R2	uniprotkb:P46935	intact:EBI-6304097|uniprotkb:Q9EQH9	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:pmepa_mouse(display_long)|uniprotkb:Pmepa1(gene name)|psi-mi:Pmepa1(display_short)|uniprotkb:N4wbp4(gene name synonym)|uniprotkb:Tmepai(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 4(gene name synonym)|uniprotkb:Prostate transmembrane protein androgen induced 1(gene name synonym)|uniprotkb:Transmembrane prostate androgen-induced protein(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304089|imex:IM-17722-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000139"(Golgi membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050699"(WW domain binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR039122|reactome:R-MMU-2173788|interpro:IPR043445	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:table 1, fig 2e and 2d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:pRPxHXpqiaNJCT3yHwy4oremn/w10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:3F223FF1D3CCA0E8|rigid:RemBTNyMRa62acPZWOKlg5lj5V4	false	sufficient binding region:139..139-c	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46935	uniprotkb:Q9D7R2	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304097|uniprotkb:Q9EQH9	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:pmepa_mouse(display_long)|uniprotkb:Pmepa1(gene name)|psi-mi:Pmepa1(display_short)|uniprotkb:N4wbp4(gene name synonym)|uniprotkb:Tmepai(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 4(gene name synonym)|uniprotkb:Prostate transmembrane protein androgen induced 1(gene name synonym)|uniprotkb:Transmembrane prostate androgen-induced protein(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304318|imex:IM-17722-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	go:"GO:0000139"(Golgi membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050699"(WW domain binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR039122|reactome:R-MMU-2173788|interpro:IPR043445	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:pRPxHXpqiaNJCT3yHwy4oremn/w10090	intact-crc:89EAE086BBADAC3B|rigid:RemBTNyMRa62acPZWOKlg5lj5V4	false	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	t7 tag:?-?|mutation decreasing interaction strength:139-139|mutation disrupting interaction strength:210-210|sufficient binding region:139..139-c	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8R182	uniprotkb:P46935	intact:EBI-6304055|ensembl:ENSMUSP00000007981|ensembl:ENSMUSP00000148014|uniprotkb:Q9EQI2	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:tmg2_mouse(display_long)|uniprotkb:Prrg2(gene name)|psi-mi:Prrg2(display_short)|uniprotkb:N4wbp1(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 1(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304432|imex:IM-17722-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007837(gene)|ensembl:ENSMUST00000210690(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|ensembl:ENSMUST00000007981(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|refseq:XP_011249190.1|refseq:NP_075375.1|refseq:XP_006541125.1|refseq:XP_006541126.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:VHlrmvld4rX8zQEgSD/q7U1h9NA10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:5023E2033185C7B6|rigid:jtM9mpsnDhSCrw8aoCsyKARIPCA	false	t7 tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:249..249-282..282|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:Q8R182	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304055|ensembl:ENSMUSP00000007981|ensembl:ENSMUSP00000148014|uniprotkb:Q9EQI2	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:tmg2_mouse(display_long)|uniprotkb:Prrg2(gene name)|psi-mi:Prrg2(display_short)|uniprotkb:N4wbp1(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 1(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304532|imex:IM-17722-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000007837(gene)|ensembl:ENSMUST00000210690(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|ensembl:ENSMUST00000007981(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|refseq:XP_011249190.1|refseq:NP_075375.1|refseq:XP_006541125.1|refseq:XP_006541126.1	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:VHlrmvld4rX8zQEgSD/q7U1h9NA10090	intact-crc:502132033185C7B6|rigid:jtM9mpsnDhSCrw8aoCsyKARIPCA	false	glutathione s tranferase tag:n-n|sufficient binding region:405..405-438..438|32p radiolabel:?-?	t7 tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9JLJ0	uniprotkb:P46935	intact:EBI-643664|uniprotkb:Q9EQI0|ensembl:ENSMUSP00000023143|ensembl:ENSMUSP00000112667	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:litaf_mouse(display_long)|uniprotkb:LITAF-like protein(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 3(gene name synonym)|uniprotkb:Estrogen-enhanced transcript protein(gene name synonym)|uniprotkb:Litaf(gene name)|psi-mi:Litaf(display_short)|uniprotkb:N4wbp3(gene name synonym)|uniprotkb:Tbx1(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304304|imex:IM-17722-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064364.1|interpro:IPR037519|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|ensembl:ENSMUSG00000022500(gene)|ensembl:ENSMUST00000023143(transcript)|ensembl:ENSMUST00000117360(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|refseq:XP_006522490.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:ZEM7+GSIEXmET3ixryvhuaMkiYk10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:AFD422641D07E57E|rigid:SC0oPHtGQw7Hw1JcozBSxJfbC3M	false	t7 tag:?-?|necessary binding region:20-23	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:Q8R0W6	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304119|ensembl:ENSMUSP00000025293|ensembl:ENSMUSP00000158314|uniprotkb:Q9EQH8	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:nfip1_mouse(display_long)|uniprotkb:Ndfip1(gene name)|psi-mi:Ndfip1(display_short)|uniprotkb:N4wbp5(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 5(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304336|imex:IM-17722-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000024425(gene)|ensembl:ENSMUST00000025293(transcript)|ensembl:ENSMUST00000236085(transcript)|go:"GO:0002761"(regulation of myeloid leukocyte differentiation)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045202"(synapse)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051224"(negative regulation of protein transport)|interpro:IPR019325|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:NP_075372.1|refseq:XP_006526212.1	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:57xO5IsBQHQhOC19LSjF8hx1V+810090	intact-crc:838F28654271C54C|rigid:KBWNmhIgkNDiGtHVU3F4hR+hwY0	false	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	t7 tag:?-?|necessary binding region:39-42	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P97764	uniprotkb:P46935	intact:EBI-6304160|uniprotkb:Q8WUP5|uniprotkb:Q99J20|ensembl:ENSMUSP00000032111	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:wbp1_mouse(display_long)|uniprotkb:Wbp1(gene name)|psi-mi:Wbp1(display_short)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304499|imex:IM-17722-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077392.1|refseq:NP_058037.2|ensembl:ENSMUSG00000030035(gene)|ensembl:ENSMUST00000032111(transcript)|go:"GO:0050699"(WW domain binding)|interpro:IPR021684|mint:P97764	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:Mt3CCbYUeFL8Ai8BSbLkGobn13Q10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:9163A1A18D35BA94|rigid:zmstzEJQKVqL23v9EbESvuv6gDk	false	t7 tag:?-?|mutation disrupting interaction strength:176-176|mutation disrupting interaction strength:162-162	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:405..405-438..438	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:Q8R0W6	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304119|ensembl:ENSMUSP00000025293|ensembl:ENSMUSP00000158314|uniprotkb:Q9EQH8	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:nfip1_mouse(display_long)|uniprotkb:Ndfip1(gene name)|psi-mi:Ndfip1(display_short)|uniprotkb:N4wbp5(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 5(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304486|imex:IM-17722-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000024425(gene)|ensembl:ENSMUST00000025293(transcript)|ensembl:ENSMUST00000236085(transcript)|go:"GO:0002761"(regulation of myeloid leukocyte differentiation)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045202"(synapse)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051224"(negative regulation of protein transport)|interpro:IPR019325|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:NP_075372.1|refseq:XP_006526212.1	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:57xO5IsBQHQhOC19LSjF8hx1V+810090	intact-crc:1BCA0BF284950777|rigid:KBWNmhIgkNDiGtHVU3F4hR+hwY0	false	glutathione s tranferase tag:n-n|sufficient binding region:249..249-282..282|32p radiolabel:?-?	t7 tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:Q9JLJ0	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-643664|uniprotkb:Q9EQI0|ensembl:ENSMUSP00000023143|ensembl:ENSMUSP00000112667	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:litaf_mouse(display_long)|uniprotkb:LITAF-like protein(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 3(gene name synonym)|uniprotkb:Estrogen-enhanced transcript protein(gene name synonym)|uniprotkb:Litaf(gene name)|psi-mi:Litaf(display_short)|uniprotkb:N4wbp3(gene name synonym)|uniprotkb:Tbx1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304557|imex:IM-17722-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	refseq:NP_064364.1|interpro:IPR037519|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|ensembl:ENSMUSG00000022500(gene)|ensembl:ENSMUST00000023143(transcript)|ensembl:ENSMUST00000117360(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|refseq:XP_006522490.1	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:ZEM7+GSIEXmET3ixryvhuaMkiYk10090	intact-crc:94EFAB3C7D180214|rigid:SC0oPHtGQw7Hw1JcozBSxJfbC3M	false	sufficient binding region:405..405-438..438|32p radiolabel:?-?|glutathione s tranferase tag:n-n	t7 tag:?-?|mutation disrupting interaction strength:23-23	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:Q9D7R2	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304097|uniprotkb:Q9EQH9	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:pmepa_mouse(display_long)|uniprotkb:Pmepa1(gene name)|psi-mi:Pmepa1(display_short)|uniprotkb:N4wbp4(gene name synonym)|uniprotkb:Tmepai(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 4(gene name synonym)|uniprotkb:Prostate transmembrane protein androgen induced 1(gene name synonym)|uniprotkb:Transmembrane prostate androgen-induced protein(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304468|imex:IM-17722-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	go:"GO:0000139"(Golgi membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050699"(WW domain binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR039122|reactome:R-MMU-2173788|interpro:IPR043445	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:pRPxHXpqiaNJCT3yHwy4oremn/w10090	intact-crc:B8FEBBF985D9D667|rigid:RemBTNyMRa62acPZWOKlg5lj5V4	false	32p radiolabel:?-?|sufficient binding region:249..249-282..282|glutathione s tranferase tag:n-n	t7 tag:?-?|mutation decreasing interaction strength:139-139|sufficient binding region:139..139-c|mutation disrupting interaction strength:210-210	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:P97765	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304181|ensembl:ENSMUSP00000074204|uniprotkb:A2A860	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:wbp2_mouse(display_long)|uniprotkb:Wbp2(gene name)|psi-mi:Wbp2(display_short)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304262|imex:IM-17722-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000034341(gene)|ensembl:ENSMUST00000074628(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043627"(response to estrogen)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|interpro:IPR004182(GRAM)|interpro:IPR033598|interpro:IPR044852|mint:P97765|refseq:NP_001334571.1|refseq:NP_058548.1	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:UAH2fbVTGZVChfiOofvZGHoQ78o10090	intact-crc:C43539EAB3B452FE|rigid:uEAeCoD0w74L22l+/MeRNKd8Fag	false	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	t7 tag:?-?|mutation decreasing interaction strength:200-200	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8R182	uniprotkb:P46935	intact:EBI-6304055|ensembl:ENSMUSP00000007981|ensembl:ENSMUSP00000148014|uniprotkb:Q9EQI2	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:tmg2_mouse(display_long)|uniprotkb:Prrg2(gene name)|psi-mi:Prrg2(display_short)|uniprotkb:N4wbp1(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 1(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304633|imex:IM-17722-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007837(gene)|ensembl:ENSMUST00000210690(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|ensembl:ENSMUST00000007981(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|refseq:XP_011249190.1|refseq:NP_075375.1|refseq:XP_006541125.1|refseq:XP_006541126.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:VHlrmvld4rX8zQEgSD/q7U1h9NA10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:502082033185C7B6|rigid:jtM9mpsnDhSCrw8aoCsyKARIPCA	false	t7 tag:?-?	32p radiolabel:?-?|sufficient binding region:460..460-493..493|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8R0W6	uniprotkb:P46935	intact:EBI-6304119|ensembl:ENSMUSP00000025293|ensembl:ENSMUSP00000158314|uniprotkb:Q9EQH8	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:nfip1_mouse(display_long)|uniprotkb:Ndfip1(gene name)|psi-mi:Ndfip1(display_short)|uniprotkb:N4wbp5(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 5(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304590|imex:IM-17722-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024425(gene)|ensembl:ENSMUST00000025293(transcript)|ensembl:ENSMUST00000236085(transcript)|go:"GO:0002761"(regulation of myeloid leukocyte differentiation)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045202"(synapse)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051224"(negative regulation of protein transport)|interpro:IPR019325|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:NP_075372.1|refseq:XP_006526212.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:57xO5IsBQHQhOC19LSjF8hx1V+810090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:1BC8DBF284950777|rigid:KBWNmhIgkNDiGtHVU3F4hR+hwY0	false	mutation decreasing interaction strength:42-42|t7 tag:?-?	32p radiolabel:?-?|sufficient binding region:405..405-438..438|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9EQG5	uniprotkb:P46935	intact:EBI-6304006|ensembl:ENSMUSP00000090931|ensembl:ENSMUSP00000131530	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:bean1_mouse(display_long)|uniprotkb:Bean1(gene name)|psi-mi:Bean1(display_short)|uniprotkb:Brain-expressed protein associating with Nedd4(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304201|imex:IM-17722-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031872(gene)|ensembl:ENSMUST00000093245(transcript)|ensembl:ENSMUST00000167633(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039352|refseq:NP_001135396.1|refseq:XP_006531333.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:KLmexu7itmtgfQoV+FKKSpQefwQ10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:3F841F85540B4A37|rigid:MPJJUpqKtYH1Qrv0N+kFWou2LeI	false	necessary binding region:141-144|necessary binding region:162-165|mutation disrupting interaction strength:144-144,165-165|glutathione s tranferase tag:n-n	sufficient binding region:249..249-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9QYK7	uniprotkb:P46935	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304542|imex:IM-17722-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:4306370BE6B9A355|rigid:QWdwEUA/ZNWioxC0QFnwmWZkGXQ	false	mutation disrupting interaction strength:40-40|t7 tag:?-?	32p radiolabel:?-?|sufficient binding region:405..405-438..438|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P97764	uniprotkb:P46935	intact:EBI-6304160|uniprotkb:Q8WUP5|uniprotkb:Q99J20|ensembl:ENSMUSP00000032111	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:wbp1_mouse(display_long)|uniprotkb:Wbp1(gene name)|psi-mi:Wbp1(display_short)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304221|imex:IM-17722-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077392.1|refseq:NP_058037.2|ensembl:ENSMUSG00000030035(gene)|ensembl:ENSMUST00000032111(transcript)|go:"GO:0050699"(WW domain binding)|interpro:IPR021684|mint:P97764	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:Mt3CCbYUeFL8Ai8BSbLkGobn13Q10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:E06CBC1D6A988082|rigid:zmstzEJQKVqL23v9EbESvuv6gDk	false	mutation disrupting interaction strength:176-176|t7 tag:?-?|mutation disrupting interaction strength:162-162	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:249..249-493..493	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9EQG5	uniprotkb:P46935	intact:EBI-6304006|ensembl:ENSMUSP00000090931|ensembl:ENSMUSP00000131530	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:bean1_mouse(display_long)|uniprotkb:Bean1(gene name)|psi-mi:Bean1(display_short)|uniprotkb:Brain-expressed protein associating with Nedd4(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304362|imex:IM-17722-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031872(gene)|ensembl:ENSMUST00000093245(transcript)|ensembl:ENSMUST00000167633(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR039352|refseq:NP_001135396.1|refseq:XP_006531333.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:KLmexu7itmtgfQoV+FKKSpQefwQ10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:4AD19D3AE60E0A9C|rigid:MPJJUpqKtYH1Qrv0N+kFWou2LeI	false	glutathione s tranferase tag:n-n|32p radiolabel:?-?|mutation disrupting interaction strength:144-144|mutation disrupting interaction strength:165-165|mutation disrupting interaction strength:165-165,144-144	sufficient binding region:460..460-493..493|sufficient binding region:405..405-438..438|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q8R182	uniprotkb:P46935	intact:EBI-6304055|ensembl:ENSMUSP00000007981|ensembl:ENSMUSP00000148014|uniprotkb:Q9EQI2	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:tmg2_mouse(display_long)|uniprotkb:Prrg2(gene name)|psi-mi:Prrg2(display_short)|uniprotkb:N4wbp1(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 1(gene name synonym)|uniprotkb:Proline-rich gamma-carboxyglutamic acid protein 2(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304278|imex:IM-17722-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007837(gene)|ensembl:ENSMUST00000210690(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|ensembl:ENSMUST00000007981(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR035972|refseq:XP_011249190.1|refseq:NP_075375.1|refseq:XP_006541125.1|refseq:XP_006541126.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:VHlrmvld4rX8zQEgSD/q7U1h9NA10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:33FD45C2D7AF9D09|rigid:jtM9mpsnDhSCrw8aoCsyKARIPCA	false	t7 tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:249..249-493..493|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P97765	uniprotkb:P46935	intact:EBI-6304181|ensembl:ENSMUSP00000074204|uniprotkb:A2A860	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:wbp2_mouse(display_long)|uniprotkb:Wbp2(gene name)|psi-mi:Wbp2(display_short)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304516|imex:IM-17722-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034341(gene)|ensembl:ENSMUST00000074628(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043627"(response to estrogen)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|interpro:IPR004182(GRAM)|interpro:IPR033598|interpro:IPR044852|mint:P97765|refseq:NP_001334571.1|refseq:NP_058548.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:UAH2fbVTGZVChfiOofvZGHoQ78o10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:48EB3AFBE96559E2|rigid:uEAeCoD0w74L22l+/MeRNKd8Fag	false	t7 tag:?-?|mutation decreasing interaction strength:200-200	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:405..405-438..438	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9QYK7	uniprotkb:P46935	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304442|imex:IM-17722-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:2317729CCE2EBE55|rigid:QWdwEUA/ZNWioxC0QFnwmWZkGXQ	false	t7 tag:?-?|mutation disrupting interaction:40-40	glutathione s tranferase tag:n-n|sufficient binding region:249..249-282..282|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9QYK7	uniprotkb:P46935	intact:EBI-4405826|uniprotkb:B1AU36|uniprotkb:B1AU37|uniprotkb:Q9EQI1|ensembl:ENSMUSP00000030284|ensembl:ENSMUSP00000063798	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:rnf11_mouse(display_long)|uniprotkb:Rnf11(gene name)|psi-mi:Rnf11(display_short)|uniprotkb:N4wbp2(gene name synonym)|uniprotkb:Sid1669(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 2(gene name synonym)|uniprotkb:Sid 1669(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304291|imex:IM-17722-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038904.1|ensembl:ENSMUSG00000028557(gene)|ensembl:ENSMUST00000030284(transcript)|ensembl:ENSMUST00000064167(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981|mint:Q9QYK7	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:nKsxQeyrkQELAS2UCfwYsNkXFdM10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:3700C382C73CA961|rigid:QWdwEUA/ZNWioxC0QFnwmWZkGXQ	false	necessary binding region:37-40|t7 tag:?-?	32p radiolabel:?-?|sufficient binding region:249..249-493..493|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9D7R2	uniprotkb:P46935	intact:EBI-6304097|uniprotkb:Q9EQH9	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:pmepa_mouse(display_long)|uniprotkb:Pmepa1(gene name)|psi-mi:Pmepa1(display_short)|uniprotkb:N4wbp4(gene name synonym)|uniprotkb:Tmepai(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 4(gene name synonym)|uniprotkb:Prostate transmembrane protein androgen induced 1(gene name synonym)|uniprotkb:Transmembrane prostate androgen-induced protein(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304572|imex:IM-17722-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000139"(Golgi membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050699"(WW domain binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR039122|reactome:R-MMU-2173788|interpro:IPR043445	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:pRPxHXpqiaNJCT3yHwy4oremn/w10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:D353E5285D5D3D3B|rigid:RemBTNyMRa62acPZWOKlg5lj5V4	false	mutation disrupting interaction strength:210-210|t7 tag:?-?|sufficient binding region:139..139-c	glutathione s tranferase tag:n-n|sufficient binding region:405..405-438..438|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P97765	uniprotkb:P46935	intact:EBI-6304181|ensembl:ENSMUSP00000074204|uniprotkb:A2A860	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:wbp2_mouse(display_long)|uniprotkb:Wbp2(gene name)|psi-mi:Wbp2(display_short)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304611|imex:IM-17722-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034341(gene)|ensembl:ENSMUST00000074628(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043627"(response to estrogen)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|interpro:IPR004182(GRAM)|interpro:IPR033598|interpro:IPR044852|mint:P97765|refseq:NP_001334571.1|refseq:NP_058548.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:UAH2fbVTGZVChfiOofvZGHoQ78o10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:48EA8AFBE96559E2|rigid:uEAeCoD0w74L22l+/MeRNKd8Fag	false	mutation disrupting interaction strength:200-200|t7 tag:?-?	glutathione s tranferase tag:n-n|sufficient binding region:460..460-493..493|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:P97765	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304181|ensembl:ENSMUSP00000074204|uniprotkb:A2A860	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:wbp2_mouse(display_long)|uniprotkb:Wbp2(gene name)|psi-mi:Wbp2(display_short)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304415|imex:IM-17722-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000034341(gene)|ensembl:ENSMUST00000074628(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043627"(response to estrogen)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045815"(epigenetic maintenance of chromatin in transcription-competent conformation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071442"(positive regulation of histone H3-K14 acetylation)|interpro:IPR004182(GRAM)|interpro:IPR033598|interpro:IPR044852|mint:P97765|refseq:NP_001334571.1|refseq:NP_058548.1	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:UAH2fbVTGZVChfiOofvZGHoQ78o10090	intact-crc:F7AA0D995885EFAF|rigid:uEAeCoD0w74L22l+/MeRNKd8Fag	false	glutathione s tranferase tag:n-n|sufficient binding region:249..249-282..282|32p radiolabel:?-?	necessary binding region:197..197-200..200|t7 tag:?-?|mutation decreasing interaction strength:252-252	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9D7R2	uniprotkb:P46935	intact:EBI-6304097|uniprotkb:Q9EQH9	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:pmepa_mouse(display_long)|uniprotkb:Pmepa1(gene name)|psi-mi:Pmepa1(display_short)|uniprotkb:N4wbp4(gene name synonym)|uniprotkb:Tmepai(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 4(gene name synonym)|uniprotkb:Prostate transmembrane protein androgen induced 1(gene name synonym)|uniprotkb:Transmembrane prostate androgen-induced protein(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304687|imex:IM-17722-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000139"(Golgi membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0010991"(negative regulation of SMAD protein complex assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050699"(WW domain binding)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070412"(R-SMAD binding)|interpro:IPR039122|reactome:R-MMU-2173788|interpro:IPR043445	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:pRPxHXpqiaNJCT3yHwy4oremn/w10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:2FFD58EEA3BEF537|rigid:RemBTNyMRa62acPZWOKlg5lj5V4	false	sufficient binding region:139..139-c|mutation disrupting interaction strength:210-210|t7 tag:?-?	glutathione s tranferase tag:n-n|32p radiolabel:?-?|sufficient binding region:460..460-493..493	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9JLJ0	uniprotkb:P46935	intact:EBI-643664|uniprotkb:Q9EQI0|ensembl:ENSMUSP00000023143|ensembl:ENSMUSP00000112667	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:litaf_mouse(display_long)|uniprotkb:LITAF-like protein(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 3(gene name synonym)|uniprotkb:Estrogen-enhanced transcript protein(gene name synonym)|uniprotkb:Litaf(gene name)|psi-mi:Litaf(display_short)|uniprotkb:N4wbp3(gene name synonym)|uniprotkb:Tbx1(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304674|imex:IM-17722-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064364.1|interpro:IPR037519|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|ensembl:ENSMUSG00000022500(gene)|ensembl:ENSMUST00000023143(transcript)|ensembl:ENSMUST00000117360(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|refseq:XP_006522490.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:ZEM7+GSIEXmET3ixryvhuaMkiYk10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:94EE1B3C7D180214|rigid:SC0oPHtGQw7Hw1JcozBSxJfbC3M	false	mutation disrupting interaction strength:23-23|t7 tag:?-?	32p radiolabel:?-?|sufficient binding region:460..460-493..493|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q9JLJ0	uniprotkb:P46935	intact:EBI-643664|uniprotkb:Q9EQI0|ensembl:ENSMUSP00000023143|ensembl:ENSMUSP00000112667	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	psi-mi:litaf_mouse(display_long)|uniprotkb:LITAF-like protein(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 3(gene name synonym)|uniprotkb:Estrogen-enhanced transcript protein(gene name synonym)|uniprotkb:Litaf(gene name)|psi-mi:Litaf(display_short)|uniprotkb:N4wbp3(gene name synonym)|uniprotkb:Tbx1(gene name synonym)	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304455|imex:IM-17722-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064364.1|interpro:IPR037519|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|ensembl:ENSMUSG00000022500(gene)|ensembl:ENSMUST00000023143(transcript)|ensembl:ENSMUST00000117360(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|refseq:XP_006522490.1	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:ZEM7+GSIEXmET3ixryvhuaMkiYk10090	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	intact-crc:F4FEEEAB558F1F14|rigid:SC0oPHtGQw7Hw1JcozBSxJfbC3M	false	t7 tag:?-?|mutation disrupting interaction strength:23-23	glutathione s tranferase tag:n-n|sufficient binding region:249..249-282..282|32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P46935	uniprotkb:Q8R0W6	intact:EBI-773516|uniprotkb:O08758|uniprotkb:Q3UZI2|uniprotkb:Q8BGB3|ensembl:ENSMUSP00000034740	intact:EBI-6304119|ensembl:ENSMUSP00000025293|ensembl:ENSMUSP00000158314|uniprotkb:Q9EQH8	psi-mi:nedd4_mouse(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:Nedd4(gene name)|psi-mi:Nedd4(display_short)|uniprotkb:Kiaa0093(gene name synonym)|uniprotkb:Nedd-4(gene name synonym)|uniprotkb:Nedd4a(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)|uniprotkb:Nedd4-1(gene name synonym)	psi-mi:nfip1_mouse(display_long)|uniprotkb:Ndfip1(gene name)|psi-mi:Ndfip1(display_short)|uniprotkb:N4wbp5(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 5(gene name synonym)	psi-mi:"MI:0047"(far western blotting)	Jolliffe et al. (2000)	imex:IM-17722|pubmed:11042109|mint:MINT-5213096	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6304706|imex:IM-17722-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035020.2|dip:DIP-32323N|ensembl:ENSMUSG00000032216(gene)|ensembl:ENSMUST00000034740(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042110"(T cell activation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46935|rcsb pdb:3M7F|reactome:R-MMU-1169408|reactome:R-MMU-1253288|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-983168	ensembl:ENSMUSG00000024425(gene)|ensembl:ENSMUST00000025293(transcript)|ensembl:ENSMUST00000236085(transcript)|go:"GO:0002761"(regulation of myeloid leukocyte differentiation)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007034"(vacuolar transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030001"(metal ion transport)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045202"(synapse)|go:"GO:0045619"(regulation of lymphocyte differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048294"(negative regulation of isotype switching to IgE isotypes)|go:"GO:0048302"(regulation of isotype switching to IgG isotypes)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050699"(WW domain binding)|go:"GO:0051224"(negative regulation of protein transport)|interpro:IPR019325|go:"GO:0050728"(negative regulation of inflammatory response)|refseq:NP_075372.1|refseq:XP_006526212.1	-	-	-	figure legend:5c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/20	2014/10/16	rogid:JBCreVF4v92fnTXZN3OH9nlW10A10090	rogid:57xO5IsBQHQhOC19LSjF8hx1V+810090	intact-crc:1BC96BF284950777|rigid:KBWNmhIgkNDiGtHVU3F4hR+hwY0	false	sufficient binding region:460..460-493..493|32p radiolabel:?-?|glutathione s tranferase tag:n-n	necessary binding region:39-42|t7 tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)