#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q95107	uniprotkb:Q95107	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287816|imex:IM-18834-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	-	-	-	figure legend:Fig 1B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	intact-crc:061C8ABC904F77B7|rigid:9LZzrMCR5LwmfohtMBed/OoQULE	false	myc tag:n-n|35s radiolabel:?-?|sufficient binding region:151-277	sufficient binding region:392-505|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q95107	uniprotkb:Q95107	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287841|imex:IM-18834-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	-	-	-	figure legend:Fig 1D.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	intact-crc:3769832739B843B9|rigid:9LZzrMCR5LwmfohtMBed/OoQULE	false	myc tag:n-n|35s radiolabel:?-?|sufficient binding region:1-277	necessary binding region:450-505|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:A7MB62	uniprotkb:Q95107	intact:EBI-6162748|ensembl:ENSBTAP00000012872	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	psi-mi:arp2_bovin(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym)	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287868|imex:IM-18834-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001095683.1|dip:DIP-29789N|ensembl:ENSBTAG00000009761(gene)|ensembl:ENSBTAT00000012872(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	-	-	-	figure legend:Fig 2B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9913	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	intact-crc:6649403FBC250783|rigid:iv0DZgpIHM0ssZ5d4aYlKHvakc4	false	-	glutathione s tranferase tag:n-n|sufficient binding region:392-505	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q95107	uniprotkb:P61157	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287885|imex:IM-18834-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	-	-	-	figure legend:Fig 2C.|comment:The association of the Arp2/3 complex subunits with N-WASP-VCA was inhibited in the presence of increasing concentrations of N-WASP-WG and N-WASP-WGP fragments.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	intact-crc:2B9714C45E591375|rigid:9ZWw7naO85ZtJfwn2p444RYCxt0	false	glutathione s tranferase tag:n-n|sufficient binding region:392-505	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q95107	uniprotkb:Q3MHR7	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	intact:EBI-6287887|ensembl:ENSBTAP00000013707|ensembl:ENSBTAP00000069123	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:arpc2_bovin(display_long)|uniprotkb:ARPC2(gene name)|psi-mi:ARPC2(display_short)|uniprotkb:Arp2/3 complex 34 kDa subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287885|imex:IM-18834-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	ensembl:ENSBTAG00000010386(gene)|ensembl:ENSBTAT00000013707(transcript)|ensembl:ENSBTAT00000070600(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|interpro:IPR007188(Arp2/3 complex, 34kDa subunit p34-Arc)|interpro:IPR034666|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|reactome:R-BTA-2029482|reactome:R-BTA-5663213|dip:DIP-29792N|refseq:NP_001029885.1	-	-	-	figure legend:Fig 2C.|comment:The association of the Arp2/3 complex subunits with N-WASP-VCA was inhibited in the presence of increasing concentrations of N-WASP-WG and N-WASP-WGP fragments.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	rogid:iwXKY2exoQRvXxdh3cIoGsF7tZc9913	intact-crc:2B9714C45E591375|rigid:9ZWw7naO85ZtJfwn2p444RYCxt0	false	glutathione s tranferase tag:n-n|sufficient binding region:392-505	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q95107	uniprotkb:Q95107	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287925|imex:IM-18834-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	-	-	-	figure legend:Fig 2C, 2D.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	intact-crc:F4C8A24D286E4320|rigid:9LZzrMCR5LwmfohtMBed/OoQULE	false	his tag:n-n|sufficient binding region:1-277	sufficient binding region:392-505|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61157	uniprotkb:Q95107	intact:EBI-351419|uniprotkb:A5PJ90|uniprotkb:P32391|uniprotkb:Q08DS8|ensembl:ENSBTAP00000066597	intact:EBI-6162776|ensembl:ENSBTAP00000006094|ensembl:ENSBTAP00000074401	psi-mi:arp3_bovin(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)|uniprotkb:Actin-2(gene name synonym)	psi-mi:wasl_bovin(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0096"(pull down)	Rohatgi et al. (2000)	pubmed:10995436|imex:IM-18834	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:1222"(mbinfo)	intact:EBI-6287951|imex:IM-18834-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776651.1|ensembl:ENSBTAG00000003401(gene)|ensembl:ENSBTAT00000070638(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042995"(cell projection)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060271"(cilium assembly)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:1K8K|rcsb pdb:1TYQ|rcsb pdb:1U2V|rcsb pdb:2P9I|rcsb pdb:2P9K|rcsb pdb:2P9L|rcsb pdb:2P9N|rcsb pdb:2P9P|rcsb pdb:2P9S|rcsb pdb:2P9U|rcsb pdb:3DXK|rcsb pdb:3DXM|rcsb pdb:3RSE|rcsb pdb:3UKR|rcsb pdb:3UKU|rcsb pdb:3ULE|rcsb pdb:4JD2|rcsb pdb:4XEI|rcsb pdb:4XF2|rcsb pdb:6DEC|dip:DIP-29790N	refseq:NP_776644.1|ensembl:ENSBTAG00000004643(gene)|ensembl:ENSBTAT00000006094(transcript)|ensembl:ENSBTAT00000074672(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0009617"(response to bacterium)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030478"(actin cap)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936	-	-	-	figure legend:Fig 2D.|comment:The interaction was inhibited in the presence of increasing concentrations of N-WASP-WG, but this inhibition was removed by stimulation with Cdc42 and PIP2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2012/09/07	2014/10/16	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9913	rogid:v4dTFUA1oNYafAFrfkpzj5jWSPY9913	intact-crc:BE0CD412795FD7E7|rigid:pnEZF092htfePI7WOYCUxjN6NHE	false	-	sufficient binding region:392-505|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)