#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P25916 uniprotkb:Q9CQJ4 intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym) psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hemenway et al. (1998) pubmed:9627119 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3954626 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 - - - figure legend:1|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/30 2014/10/16 rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 intact-crc:4590F1C62EFDFF95|rigid:yX3KLFI7B2oLdd3wn3cuX9GgSwE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9QWH1 uniprotkb:Q9CQJ4 intact:EBI-642357|uniprotkb:O88463|uniprotkb:Q8K5D9|uniprotkb:B1AS98|uniprotkb:B1ASA4|ensembl:ENSMUSP00000030588|ensembl:ENSMUSP00000101690 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 psi-mi:phc2_mouse(display_long)|uniprotkb:p36(gene name synonym)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:Phc2(gene name)|psi-mi:Phc2(display_short)|uniprotkb:Edr2(gene name synonym)|uniprotkb:Ph2(gene name synonym) psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hemenway et al. (1998) pubmed:9627119 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3954630 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182012.1|refseq:NP_001182059.1|refseq:NP_061244.1|refseq:XP_006503300.1|refseq:XP_006503301.1|ensembl:ENSMUSG00000028796(gene)|ensembl:ENSMUST00000030588(transcript)|ensembl:ENSMUST00000106080(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038603|mint:Q9QWH1|rcsb pdb:2NA1|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:XP_017175809.1 refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 - - - figure legend:none|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/30 2014/10/16 rogid:nNgSS7uHUP3sCDlztQJqi2zl2EU10090 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 intact-crc:63DA41E36C91645B|rigid:fhcVUFn1U7a8Q0jF5IJcuhFrNMw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P25916 uniprotkb:Q9CQJ4 intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym) psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hemenway et al. (1998) pubmed:9627119 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3954641 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 - - - figure legend:Figs. 1 and 3|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/30 2014/10/16 rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 intact-crc:18CFC6807F1D9B68|rigid:yX3KLFI7B2oLdd3wn3cuX9GgSwE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9CQJ4 uniprotkb:P25916 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300 psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hemenway et al. (1998) pubmed:9627119 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3954645 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 - - - figure legend:2|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/30 2014/10/16 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090 intact-crc:354E7BAE22EBEB24|rigid:yX3KLFI7B2oLdd3wn3cuX9GgSwE false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9QWH1 uniprotkb:Q9CQJ4 intact:EBI-642357|uniprotkb:O88463|uniprotkb:Q8K5D9|uniprotkb:B1AS98|uniprotkb:B1ASA4|ensembl:ENSMUSP00000030588|ensembl:ENSMUSP00000101690 intact:EBI-927321|uniprotkb:O35699|uniprotkb:O35729|uniprotkb:Q4FJV5|uniprotkb:Q8C1X8|ensembl:ENSMUSP00000075476|ensembl:ENSMUSP00000140896 psi-mi:phc2_mouse(display_long)|uniprotkb:p36(gene name synonym)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:Phc2(gene name)|psi-mi:Phc2(display_short)|uniprotkb:Edr2(gene name synonym)|uniprotkb:Ph2(gene name synonym) psi-mi:ring2_mouse(display_long)|uniprotkb:Rnf2(gene name)|psi-mi:Rnf2(display_short)|uniprotkb:DinG(gene name synonym)|uniprotkb:Ring1b(gene name synonym)|uniprotkb:RING finger protein 2(gene name synonym)|uniprotkb:RING finger protein 1B(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hemenway et al. (1998) pubmed:9627119 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3954653 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182012.1|refseq:NP_001182059.1|refseq:NP_061244.1|refseq:XP_006503300.1|refseq:XP_006503301.1|ensembl:ENSMUSG00000028796(gene)|ensembl:ENSMUST00000030588(transcript)|ensembl:ENSMUST00000106080(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038603|mint:Q9QWH1|rcsb pdb:2NA1|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:XP_017175809.1 refseq:NP_035407.1|dip:DIP-36109N|ensembl:ENSMUSG00000026484(gene)|ensembl:ENSMUST00000076110(transcript)|ensembl:ENSMUST00000187048(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007281"(germ cell development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010467"(gene expression)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071535"(RING-like zinc finger domain binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR037937|interpro:IPR043540|mint:Q9CQJ4|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 - - - figure legend:4 and table I|comment:"Bmi1 (AC P25916) is enhancing the interaction"|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/30 2014/10/16 rogid:nNgSS7uHUP3sCDlztQJqi2zl2EU10090 rogid:xyEv6lhWHdmO1fLEas7lRd3wbco10090 intact-crc:2CDE06C97F7594FA|rigid:fhcVUFn1U7a8Q0jF5IJcuhFrNMw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9QWH1 uniprotkb:P25916 intact:EBI-642357|uniprotkb:O88463|uniprotkb:Q8K5D9|uniprotkb:B1AS98|uniprotkb:B1ASA4|ensembl:ENSMUSP00000030588|ensembl:ENSMUSP00000101690 intact:EBI-927401|ensembl:ENSMUSP00000028071|ensembl:ENSMUSP00000110300 psi-mi:phc2_mouse(display_long)|uniprotkb:p36(gene name synonym)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:Phc2(gene name)|psi-mi:Phc2(display_short)|uniprotkb:Edr2(gene name synonym)|uniprotkb:Ph2(gene name synonym) psi-mi:bmi1_mouse(display_long)|uniprotkb:Bmi1(gene name)|psi-mi:Bmi1(display_short)|uniprotkb:Pcgf4(gene name synonym)|uniprotkb:Bmi-1(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Hemenway et al. (1998) pubmed:9627119 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0486"(UniProt) intact:EBI-3954658 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001182012.1|refseq:NP_001182059.1|refseq:NP_061244.1|refseq:XP_006503300.1|refseq:XP_006503301.1|ensembl:ENSMUSG00000028796(gene)|ensembl:ENSMUST00000030588(transcript)|ensembl:ENSMUST00000106080(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038603|mint:Q9QWH1|rcsb pdb:2NA1|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:XP_017175809.1 refseq:NP_031578.2|refseq:XP_006497374.1|refseq:XP_006497375.1|ensembl:ENSMUSG00000026739(gene)|ensembl:ENSMUST00000028071(transcript)|ensembl:ENSMUST00000051929(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|dip:DIP-132N|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009987"(cellular process)|go:"GO:0016573"(histone acetylation)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P25916|rcsb pdb:2CKL|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750 - - - figure legend:4 and Table I|comment:"Rnf2 (AC Q9CQJ4) is enhancing the interaction"|curation depth:mimix curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2011/05/30 2014/10/16 rogid:nNgSS7uHUP3sCDlztQJqi2zl2EU10090 rogid:xqs8rfZzDnr99TmUEdISjicPiqQ10090 intact-crc:0CC46DBA5F99EDB8|rigid:V8YQyAfXhNC0n9HB/Cq+qAk2T5I false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)